Wolfram Ruf
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Physics Mathematics
Wolfram Ruf's Degrees
- Masters Applied Mathematics ETH Zurich
- Bachelors Mathematics University of Zurich
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(Suggest an Edit or Addition)Wolfram Ruf's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway (2002) (856)
- The Structural Biology of Expression and Function of Tissue Factor (1991) (586)
- Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. (1991) (524)
- Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. (1992) (395)
- Regulation of angiogenesis by tissue factor cytoplasmic domain signaling (2004) (350)
- Disulfide isomerization switches tissue factor from coagulation to cell signaling (2006) (346)
- A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280 (1998) (331)
- Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor (2001) (327)
- Inhibition of tissue factor signaling suppresses tumor growth. (2008) (319)
- Inflammation, obesity, and thrombosis. (2012) (310)
- Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. (2012) (290)
- Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation (2008) (281)
- Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells (2011) (260)
- Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. (1998) (258)
- Protease-activated receptor 2 signaling in inflammation (2011) (258)
- Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1 (1994) (240)
- Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line (1989) (238)
- Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. (2004) (238)
- Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor- dependent coagulation pathway (1996) (223)
- Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling (2012) (221)
- Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer (2005) (217)
- Specificity of coagulation factor signaling (2003) (205)
- Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling* (2005) (204)
- Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. (2001) (193)
- Evidence for activation of tissue factor by an allosteric disulfide bond. (2006) (192)
- Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. (2008) (191)
- Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. (1996) (177)
- Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. (2017) (176)
- Thrombin generation and the pathogenesis of cancer. (2006) (168)
- Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. (1991) (162)
- Alternatively spliced tissue factor induces angiogenesis through integrin ligation (2009) (155)
- P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. (2011) (154)
- Tissue factor and cell signalling in cancer progression and thrombosis (2011) (149)
- Tissue factor in cancer angiogenesis and metastasis (1996) (146)
- Plasmin-induced Migration of Endothelial Cells (2002) (138)
- Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. (2008) (135)
- Cross-talk of integrin α3β1 and tissue factor in cell migration (2004) (133)
- Protease-activated Receptor 2-dependent Phosphorylation of the Tissue Factor Cytoplasmic Domain* (2004) (130)
- Emerging insights in tissue factor-dependent signaling events. (2006) (123)
- Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry. (2003) (122)
- Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. (2006) (121)
- Tissue Factor Coagulant Function Is Enhanced by Protein-disulfide Isomerase Independent of Oxidoreductase Activity* (2007) (119)
- Tissue factor in cancer progression and angiogenesis. (2010) (117)
- PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2015) (115)
- Role of Protease Activated Receptor 1 and 2 Signaling in Hypoxia-Induced Angiogenesis (2007) (112)
- Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. (1995) (111)
- The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. (1998) (110)
- Role of Zymogen and Activated Factor X as Scaffolds for the Inhibition of the Blood Coagulation Factor VIIa-Tissue Factor Complex by Recombinant Nematode Anticoagulant Protein c2* (2001) (107)
- Science review: Role of coagulation protease cascades in sepsis (2002) (106)
- An Anti-Tissue Factor Monoclonal Antibody which Inhibits TF Vlla Complex Is a Potent Anticoagulant in Plasma (1991) (101)
- Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. (1995) (101)
- Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. (1991) (101)
- Tissue factor-PAR2 signaling promotes diet-induced obesity and adipose inflammation (2011) (100)
- Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor. (1999) (100)
- Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation. (2003) (99)
- Tissue Factor: molecular recognition and cofactor function (1995) (99)
- Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. (2017) (99)
- Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. (2010) (97)
- The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. (1991) (96)
- Tissue factor and PAR2 signaling in the tumor microenvironment. (2009) (94)
- Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase. (2013) (93)
- Tissue factor at the crossroad of coagulation and cell signaling (2018) (92)
- Orchestration of coagulation protease signaling by tissue factor. (2002) (92)
- The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors* (2010) (91)
- Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension (2019) (91)
- Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. (2004) (89)
- Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1. (2005) (88)
- Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. (2015) (86)
- Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. (2009) (85)
- Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension (2017) (84)
- Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor. (2000) (84)
- Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. (1992) (84)
- Evidence for tissue factor phosphorylation and its correlation with protease‐activated receptor expression and the prognosis of primary breast cancer (2009) (84)
- Effector Cell Protease Receptor-1 Is a Vascular Receptor for Coagulation Factor Xa* (1996) (84)
- Recombinant soluble human tissue factor secreted by Saccharomyces cerevisiae and refolded from Escherichia coli inclusion bodies: glycosylation of mutants, activity and physical characterization. (1995) (83)
- Exosite Interactions Determine the Affinity of Factor X for the Extrinsic Xase Complex* (2000) (83)
- Activated protein C signals through the thrombin receptor PAR1 in endothelial cells (2003) (82)
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2 (2019) (81)
- Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. (1994) (79)
- Tissue Factor Signaling (1999) (78)
- Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells (2009) (72)
- Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation (2014) (71)
- Plasmin-induced Migration Requires Signaling through Protease-activated Receptor 1 and Integrin α9β1* (2004) (71)
- Regulation of Tissue Factor—Mediated Initiation of the Coagulation Cascade by Cell Surface Grp78 (2005) (67)
- Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock. (1992) (64)
- Tissue factor residues 157-167 are required for efficient proteolytic activation of factor X and factor VII. (1992) (64)
- Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner (2013) (64)
- Active Site Modification of Factor VIIa Affects Interactions of the Protease Domain with Tissue Factor* (1997) (64)
- Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. (2007) (61)
- Splice variants of tissue factor promote monocyte‐endothelial interactions by triggering the expression of cell adhesion molecules via integrin‐mediated signaling (2011) (61)
- Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. (1991) (61)
- Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development (2013) (60)
- The tissue factor/factor VIIa/factor Xa complex: A model built by docking and site‐directed mutagenesis (2003) (59)
- The Structural Basis of Function of the TF●VIIa Complex in the Cellular Initiation of Coagulation (1997) (59)
- Tissue factor and protease-activated receptor signaling in cancer. (2008) (58)
- EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. (2015) (58)
- Cell Surface Proteomics Identifies Molecules Functionally Linked to Tumor Cell Intravasation* (2008) (57)
- Tissue factor-dependent coagulation protease signaling in acute lung injury (2003) (57)
- Role of PAR2 in murine pulmonary pseudomonal infection. (2008) (54)
- Factor VIIa residue Arg290 is required for efficient activation of the macromolecular substrate factor X. (1994) (52)
- Myeloid cell–synthesized coagulation factor X dampens antitumor immunity (2019) (52)
- Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. (2017) (52)
- Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa. (1998) (52)
- Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids (2009) (51)
- Immunochemical termination of self-tolerance (2008) (51)
- Measurement and Simulation of Transient Tire Forces (1989) (50)
- Antibody mapping of tissue factor implicates two different exon-encoded regions in function. (1991) (49)
- Neutrophils release brakes of coagulation (2010) (46)
- Lipid presentation by the protein C receptor links coagulation with autoimmunity (2021) (45)
- Key ligand interface residues in tissue factor contribute independently to factor VIIa binding. (1994) (45)
- Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases (2009) (45)
- Factor VII–Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor (2012) (44)
- Emerging roles of tissue factor in viral hemorrhagic fever. (2004) (44)
- Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling. (2018) (43)
- Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor VIIa. (1998) (43)
- Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain. (1999) (42)
- Macromolecular Substrate Affinity for the Tissue Factor-Factor VIIa Complex Is Independent of Scissile Bond Docking* (1999) (42)
- Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis (2018) (42)
- The tick‐derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells (2012) (41)
- Tissue factor and glycoprotein C on herpes simplex virus type 1 are protease-activated receptor 2 cofactors that enhance infection. (2012) (41)
- Energetic contributions and topographical organization of ligand binding residues of tissue factor. (1995) (41)
- Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma (2014) (41)
- Residue Met156 Contributes to the Labile Enzyme Conformation of Coagulation Factor VIIa* (2001) (40)
- Diverse functions of protease receptor tissue factor in inflammation and metastasis (2000) (40)
- High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors (2015) (40)
- Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). (2004) (40)
- Tissue factor and PAR signaling in tumor progression. (2007) (40)
- Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. (2018) (40)
- Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa. (1991) (38)
- HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells (2012) (38)
- Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking (2017) (37)
- Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy (2016) (36)
- Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes (2005) (36)
- Protease-activated receptor signaling in the regulation of inflammation (2004) (36)
- Tissue factor and cancer. (2012) (35)
- Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa. (2000) (35)
- Organ-Specific Protection Against Lipopolysaccharide-Induced Vascular Leak Is Dependent on the Endothelial Protein C Receptor (2013) (35)
- Extravascular coagulation in hematopoietic stem and progenitor cell regulation. (2018) (34)
- Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies. (2018) (34)
- New players in the sepsis-protective activated protein C pathway. (2010) (34)
- Engineering of Substrate Selectivity for Tissue Factor·Factor VIIa Complex Signaling through Protease-activated Receptor 2* (2010) (33)
- Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis. (2019) (33)
- Thiol pathways in the regulation of tissue factor prothrombotic activity (2011) (33)
- The molecular biology of initiation of coagulation by tissue factor. (1991) (32)
- Factor Xa Binding to Annexin 2 Mediates Signal Transduction via Protease-Activated Receptor 1 (2008) (32)
- Contributions of thrombin targets to tissue factor‐dependent metastasis in hyperthrombotic mice (2014) (32)
- Tissue factor proangiogenic signaling in cancer progression. (2012) (31)
- Ca2+ Binding to the First Epidermal Growth Factor Module of Coagulation Factor VIIa Is Important for Cofactor Interaction and Proteolytic Function* (1997) (31)
- Thrombin-induced fibrinopeptide B release from normal and variant fibrinogens: influence of inhibitors of fibrin polymerization. (1988) (30)
- Tissue factor residues Lys165 and Lys166 are essential for rapid formation of the quaternary complex of tissue factor.VIIa with Xa.tissue factor pathway inhibitor. (1995) (29)
- Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. (2015) (29)
- Activated protein C in sepsis: the promise of nonanticoagulant activated protein C (2008) (29)
- PAR1 signaling: more good than harm? (2003) (27)
- Dimerization of tissue factor supports solution-phase autoactivation of factor VII without influencing proteolytic activation of factor X. (2000) (27)
- Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition. (2002) (27)
- THROMBOSIS AND HEMOSTASIS EPCR-dependent PAR 2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice (2015) (26)
- Vascular and dendritic cell coagulation signaling in sepsis progression (2009) (26)
- Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation (2004) (26)
- Molecular regulation of blood clotting in tumor biology. (2001) (26)
- Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. (2017) (26)
- Tissue factor pathways linking obesity and inflammation (2015) (25)
- Regulation of the catalytic function of coagulation factor VIIa by a conformational linkage of surface residue Glu 154 to the active site. (1999) (25)
- Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice. (2015) (25)
- Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression (2017) (24)
- Regulation of long‐term repopulating hematopoietic stem cells by EPCR/PAR1 signaling (2016) (24)
- Redundant signaling of tissue factor and thrombin in cancer progression? (2007) (24)
- Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes (2020) (23)
- Nox2+ Myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1. (2020) (22)
- The procoagulant envelope virus surface: contribution to enhanced infection. (2014) (22)
- Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region. (2009) (21)
- Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis. (2019) (20)
- Role of the protein C receptor in cancer progression. (2014) (20)
- Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity. (2010) (20)
- Tissue factor associates with survival and regulates tumour progression in osteosarcoma (2016) (20)
- Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor (2011) (19)
- Immunomodulatory drugs increase endothelial tissue factor expression in vitro. (2011) (19)
- The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site. (1992) (18)
- Course of D-Dimer and C-Reactive Protein Levels in Survivors and Nonsurvivors with COVID-19 Pneumonia: A Retrospective Analysis of 577 Patients (2020) (18)
- Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation. (1997) (18)
- Targeting clotting proteins in cancer therapy - progress and challenges. (2016) (18)
- Effect of protein disulfide isomerase chaperone activity inhibition on tissue factor activity (2010) (17)
- Syndecan-3 and TFPI Colocalize on the Surface of Endothelial-, Smooth Muscle-, and Cancer Cells (2015) (17)
- TF:FVIIa‐specific activation of CREB upregulates proapoptotic proteins via protease‐activated receptor‐2 (2008) (16)
- The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury (2015) (16)
- The interaction of activated factor VII with tissue factor: insight into the mechanism of cofactor-mediated activation of activated factor VII. (1998) (16)
- Nonproteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models (2012) (15)
- Purification, sequence and crystallization of an anti-tissue factor Fab and its use for the crystallization of tissue factor (1992) (15)
- PAR 1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2016) (15)
- Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles (2019) (15)
- Tissue Factor residue Asp44 regulates catalytic function of the bound proteinase Factor VIIa. (1996) (14)
- Endothelial protein C receptor is required for tissue factor ternary complex signaling in the mouse (2011) (14)
- Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation. (2018) (14)
- Role of thiol pathways in TF procoagulant regulation. (2012) (14)
- Engineered recombinant factor VII Q217 variants with altered inhibitor specificities. (1999) (13)
- Regulation of Tissue Factor Expression (2013) (13)
- Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice (2020) (13)
- Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity (2018) (12)
- Proteases, Protease-Activated Receptors, and Atherosclerosis. (2018) (12)
- Links Between Complement Activation and Thrombosis (2019) (12)
- Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions (2021) (12)
- Anticoagulation with Factor Xa Inhibitors Is Associated with Improved Overall Response and Progression-Free Survival in Patients with Metastatic Malignant Melanoma Receiving Immune Checkpoint Inhibitors—A Retrospective, Real-World Cohort Study (2021) (12)
- Tissue Factor-Dependent Signaling in Tumor Biology (2003) (11)
- Pathogenic lipid‐binding antiphospholipid antibodies are associated with severity of COVID‐19 (2021) (11)
- Mutational analysis of receptor and cofactor function of tissue factor. (1993) (11)
- Rivaroxaban Effects Illustrate the Underestimated Importance of Activated Platelets in Thrombin Generation Assessed by Calibrated Automated Thrombography (2019) (11)
- Virus envelope tissue factor promotes infection in mice (2019) (10)
- Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy. (2020) (10)
- Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment (2018) (10)
- The Role of Catalytic Cleft and Exosite Residues of Factor VIIa for Complex Formation with Tissue Factor Pathway Inhibitor (2001) (10)
- Tissue factor and its procoagulant activity on cancer‐associated thromboembolism in pancreatic cancer (2021) (10)
- Hemostasis and Angiogenesis (2007) (10)
- Erratum: Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function (The Journal of Biological Chemistry, Vol. 266 (1991) 2158-2166) (1991) (9)
- Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes (2020) (9)
- FXa takes center stage in vascular inflammation. (2014) (9)
- Roles of factor Xa beyond coagulation (2021) (9)
- Infrared fluorescence for vascular barrier breach in vivo – A novel method for quantitation of albumin efflux (2012) (8)
- Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa (2009) (8)
- Microbiota-Derived Trimethylamine. (2018) (8)
- HIF2a-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells (2012) (7)
- Advocacy of targeting protease‐activated receptors in severe coronavirus disease 2019 (2021) (7)
- State of the Art 2017 (2017) (7)
- Bacitracin and Rutin Regulate Tissue Factor Production in Inflammatory Monocytes and Acute Myeloid Leukemia Blasts (2021) (7)
- PROTEASE-ACTIVATED RECEPTOR (PAR)1 ALTERS BIOELECTRIC PROPERTIES OF DISTAL LUNG EPITHELIA WITHOUT COMPROMISING BARRIER FUNCTION (2009) (6)
- Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models (2018) (6)
- Tissue factor activation involves disulfide switching (2005) (6)
- Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells (2016) (6)
- Inflammatory Monocyte Counts Determine Venous Blood Clot Formation and Resolution (2021) (6)
- Engineering of a membrane-triggered activity switch in coagulation factor VIIa (2017) (6)
- Regulation of tissue factor in NT2 germ cell tumor cells by cisplatin chemotherapy. (2015) (6)
- Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice. (2018) (5)
- Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis (2018) (5)
- Proteinase‐activated receptor activation by coagulation proteinases (2003) (5)
- Factor VIIa‐induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells (2019) (5)
- Metabolic and inflammatory reprogramming of macrophages by ONC201 translates in a pro‐inflammatory environment even in presence of glioblastoma cells (2020) (5)
- Coagulation signaling and cancer immunotherapy. (2020) (5)
- Hemostasis keeps the stem cell niche in order. (2016) (5)
- Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). (2015) (5)
- Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial (2022) (5)
- Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice (2020) (5)
- Mechanism of Action of Hydroxychloroquine in the Antiphospholipid Syndrome (2016) (4)
- Is VITT really a HIT (2021) (4)
- Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy (2022) (4)
- LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis (2019) (4)
- Influence of prostaglandin A1 on renal filtration, hemodynamics and excretion. Investigations in chronically instrumented conscious dogs on a low- and high-sodium diet. (1983) (4)
- Alternatively Spliced Tissue Factor Is Not Sufficient for Embryonic Development (2014) (4)
- Crystallization and preliminary crystallographic data for a ternary complex between tissue factor, factor VIIa and a BPTI-derived inhibitor (1996) (3)
- High PAI activity with correlation to triglyceride and HDL cholesterol values in patients with coronary artery disease with no difference in survivors of myocardial infarction (1993) (3)
- A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen. (2004) (3)
- CD248 enhances tissue factor procoagulant function, promoting arterial and venous thrombosis in mouse models (2021) (3)
- The EHA Research Roadmap: Blood Coagulation and Hemostatic Disorders (2021) (3)
- Tissue factor phosphorylation requires protease activated receptor-2 expression: Correlation with the prognosis of human breast cancer (2010) (3)
- EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels (2015) (2)
- Tissue Factor (TF) Activation by Antithymocyte Globulin Is Inhibited by a Novel Monoclonal Antibody Specific for Reduced TF Mutated at the Allosteric Cys186-Cys209 Disulfide. (2010) (2)
- Molecular Switch between Tissue Factor-Mediated Signaling and Coagulation. (2005) (2)
- OC-09 - Microparticle-mediated transfer of TF hypercoagulability between cancer cells. (2016) (2)
- ISTH 2017 Berlin revisited (2017) (2)
- Factor Xa and Factor VIIa Utilize Herpes Simplex Virus-Associated Tissue Factor to Increase Infection through Cellular Protease Activated Receptor 2. (2009) (2)
- Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure (2022) (2)
- Tissue Factor On The Herpes Simplex Virus Type 1 Surface Enhances Infection In Vivo (2013) (2)
- Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids. (2020) (2)
- New helpers in TF‐dependent migration (2013) (2)
- S1P/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction (2022) (2)
- Proangiogenic TF-FVIIa-PAR2 Signaling Requires Matriptase-Independent Integrin Interaction (2016) (2)
- Immunomodulatory Drugs (Thalidomide and Lenalidomide) Up-Regulate Endothelial Tissue Factor in Vitro Resulting in An Acquired Hypercoagulable State. (2008) (1)
- Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway (2013) (1)
- Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from (2005) (1)
- P2×7 Signaling Triggers Tissue Factor Activation and Protein Disulfide Isomerase-Dependent Release of TF+ Microparticles In Thrombosis (2010) (1)
- PAR4 antagonists in inflammation (2007) (1)
- Translational Research in Thrombosis and Haemostasis (2019) (1)
- Protease‐ and cell type–specific activation of protease‐activated receptor 2 in cutaneous inflammation (2022) (1)
- Authors' reply to the Letter to the Editor: Tissue factor and its procoagulant activity on cancer‐associated thromboembolism in pancreatic cancer (2022) (1)
- Macrophage Factor Xa Signaling Promotes Cancer Immune Evasion (2018) (1)
- Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation (2021) (1)
- Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation (2010) (1)
- EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia (2022) (1)
- Inverse PAR1 Activity of Hematopoietic Stem Cells and BM Stromal Cells Mediates G-CSF-Induced Mobilization By Regulation of Nitric Oxide Generation (2016) (1)
- The Role of Coagulation Factor Signaling in Angiogenesis and Vascular Remodeling (2015) (1)
- protease-activated receptor 1 Gene induction by coagulation factor Xa is mediated by activation of (2013) (1)
- Signaling by Activated Protein C in Endothelial Cells Is PAR1 Dependent but Distinct from Thrombin Signaling. (2004) (1)
- Platelet glycoprotein V spatio-temporally controls fibrin formation (2023) (1)
- Lack of LRP8 triggers the formation of aortic dissection in angiotensin II infused mice (2020) (1)
- Contribution of Intrinsic and Extrinsic Coagulation Pathways to Thrombus Formation in the Mouse Carotid Artery. (2008) (1)
- Flow perturbation is linked to endothelial par signaling. (2006) (1)
- The Endothelial Protein C Receptor Supports TF-VIIa-Xa Ternary Complex Signaling through Protease-Activated Receptors. (2010) (1)
- Abstract B19: Brain metastasis depends on tumor cell initiated coagulation (2014) (1)
- EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling (2013) (1)
- Factor V Inhibits PAR2-Mediated Lethal Inflammation (2012) (1)
- Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition (2014) (1)
- EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance (2016) (1)
- Abstract 113: Novel Tissue Factor Inhibition For Thromboprophylaxis In COVID-19: Primary Results Of The ASPEN-COVID-19 Phase 2b Randomized Trial (2022) (0)
- Coagulation signaling from amniotic fluid to fetal skin (2022) (0)
- Method for increasing the controllability of a vehicle. (1988) (0)
- Method for improving the controllability of motor vehicles during braking (1990) (0)
- Anti-skid controller (1987) (0)
- Method for controlling the vehicle stability (1992) (0)
- Integrin Alphav-beta3 on Podocytes Orchestrates Coagulation Protease Signaling through Protease-Activated Receptors (2018) (0)
- Endothelial Protein C Receptor regulates skin gamma delta T cell functions (2016) (0)
- Gpibα Engagement Induces Activation of Human Platelet TF and Association with Constitutively Platelet Surface-Bound FVIIa (2019) (0)
- Distinct Roles of the Extrinsic and the Intrinsic Coagulation Pathways In Different Murine Thrombosis Models (2011) (0)
- Blocking EPCR decreases tumor growth of human breast cancer cells. (2013) (0)
- P1.3: A NEW DYNAMIC ORGAN BATH SETUP TO ASSESS ISOBARIC STIFFNESS PARAMETERS OF PERIODICALLY STRETCHED ISOLATED MOUSE AORTIC SEGMENTS (0)
- Abstract 4274: HIF2α/Sp1/mTOR interaction mediates a deacetylation-dependentFVIIgene activation under serum deprived condition in ovarian cancer cells (2012) (0)
- Blocking Tissue Factor signaling in breast cancer inhibits tumor metastasis (2018) (0)
- P6558The endothelial-derived miR-181 regulates tissue factor-dependent extrinsic clotting (2018) (0)
- Inhibition of protein disulfide isomerase with PACMA-31 regulates monocyte tissue factor through transcriptional and posttranscriptional mechanisms (2022) (0)
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2 (2019) (0)
- MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR (1998) (0)
- Novel Interactions Between Complement Proteins and Hemostatic Factors in Venous Thrombus Development (2018) (0)
- Tissue factor-factor VIIA pathway regulates gene expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase in human cancer cells (1999) (0)
- and Ruf TF and PAR 2 Signaling in the Tumor Microenvironment 2001 (2009) (0)
- Faculty Opinions recommendation of Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS. (2014) (0)
- Crohn’s disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice (2023) (0)
- P.30 Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice (2020) (0)
- P231Molecular and cellular components of human carotid artery plaque related to thrombogenicity (2014) (0)
- Abstract 367: Aberrant expression of TFPI-1 associated with low procoagulant activity of liver cancer cells. (2013) (0)
- Abstract 1512: Hypoxic activation ofFVIIgene in cancer cells mediated by interaction among HIF2α, Sp1, and HDAC4 (2011) (0)
- A3 CROHN’S DISEASE PROTEOLYTIC MICROBIOTA ENHANCES INFLAMMATION THROUGH PAR2 PATHWAY IN GNOTOBIOTIC MICE (2023) (0)
- severely impaired in decrypted procoagulant activity disulfide bond is 209 -Cys 186 Tissue factor mutated at the allosteric Cys (2013) (0)
- PAR–2 Mediated Angiogenesis in the OIR Model is Regulated by the Cytoplasmic Tail of Tissue Factor (2005) (0)
- Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality. (2019) (0)
- TLT-1 Regulates Thrombus Growth Under Non-Inflammatory Conditions (2021) (0)
- Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality (2019) (0)
- EPCR Signaling Controls the Activity of Hematopoietic Stem Cells Independent of Coagulation Regulation (2021) (0)
- A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) (1998) (0)
- P913Lack of tissue factor cytoplasmic tail attenuates cardiac injury after myocardial infarction (2018) (0)
- A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release (2014) (0)
- Integrin regulation by tissue factor promotes cancer stemness and metastatic dissemination in breast cancer (2022) (0)
- 349 Contact hypersensitivity is impaired in the absence of tissue factor- and protease-activated receptor 2-mediated signaling (2016) (0)
- Center for Thrombosis and Hemostasis Mainz. (2019) (0)
- Ruf Flow Perturbation Is Linked to Endothelial PAR Signaling 963 (2006) (0)
- Platelet-localized FXI promotes a glycoprotein Ibα dependent feedback loop in arterial hypertension and vascular inflammation (2015) (0)
- Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. (2023) (0)
- 345 Tissue factor and protease-activated receptor-2 signaling control cutaneous inflammation in mice (2017) (0)
- Chapter 5 - Non-Proteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models (2013) (0)
- ID: 238 Protease Signaling in Angiogenesis and Cancer (2006) (0)
- Abstract 32: Coagulation Factor XI and Thrombin Mediate Angiotensin II-induced Vascular Dysfunction (2015) (0)
- 943 The critical role of PAR2 signaling in myeloid immune cells in contact hypersensitivity (2018) (0)
- Molecular Biology of Tf (1995) (0)
- Nox2+ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1 (2020) (0)
- transfer of TF from megakaryocytes to platelets Diverse packaging of TF into platelets (2017) (0)
- Abstract 43: Recycling Controls Procoagulant and Cell Signaling Functions of Tissue Factor (2015) (0)
- TRIF turns the switch for DIC in sepsis. (2020) (0)
- Crystal Structure of tissue factor-factor VIIa complex (2004) (0)
- Theoretical model of the tissue factor/factor VIIa/factor Xa complex (2003) (0)
- Suppression of Breast Cancer Progression by Tissue Factor (2004) (0)
- B lymphocyte-deficiency in mice promotes venous thrombosis (2022) (0)
- PAR–2 Activation by TF–FVIIa Complex Results in Accelerated Angiogenesis in TFCT Mice (2006) (0)
- Protease Signaling in Severe Systemic Inflammation. (2006) (0)
- Gene Profiling of Protease Induced Genes in Breast Cancer (2001) (0)
- Single housing reduces lung hemorrhages in male mice with tissue factor disulfide mutation and protects them from lethality (2013) (0)
- FIBRINOPEPTIDE B RELEASE FROM NORMAL FIBRINOGEN AND FIBRINOGEN LONDON I IN THE PRESENCE OF INHIBITORS OF FIBRIN POLYMERIZATION (1987) (0)
- Protease-activated receptor 2 signaling in inflammation (2011) (0)
- disulfide-deficient tissue factor Complete abolishment of coagulant activity in monomeric (2013) (0)
- 419 Impaired fibrinolysis in coronary artery disease patients due to elevated plasma PAI capacity and impaired tPA release (1988) (0)
- Crystal structure of extracellular domain of tissue factor complexes with an inhibitory Fab (1996) (0)
- Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection (2022) (0)
- Tissue factor-PAR2 signaling crosstalk in cancer and angiogenesis (2009) (0)
- 065 Factor XA and factor VIIA utilize herpes simplex virus-associated tissue factor to increase infection through cellular protease activated receptor 2 (2011) (0)
- Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation (2015) (0)
- Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling*□S (2005) (0)
- A48 COLITIS FAVORS THE EXPANSION OF BACTERIA THAT ACTIVATE PAR2 AMPLIFYING INFLAMMATORY RESPONSE (2020) (0)
- Chronically Elevated Interleukin-6 Disturbs the Coagulation Cascade in Mice (2021) (0)
- Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity. (2007) (0)
- Discussion of talks from the symposium: Factor X: From thrombokinase to oral anti-coagulants and beyond (2021) (0)
- EPCR Raft Signaling Controls Activity of Hematopoietic Progenitor and Stem Cells (2019) (0)
- Diverse packaging of TF into platelets (2015) (0)
- palmitoylation Regulation of tissue factor cytoplasmic domain phosphorylation by (2013) (0)
- Tissue factor cytoplasmic tail regulates myeloid cell derived superoxide formation and TGF-beta 1 driven cardiac remodeling in myocardial infarction (2020) (0)
- Regulation of Tissue Factor Signaling by Tissue Factor Pathway Inhibitor. (2004) (0)
- P1.5: AGE AND HYPERTENSION STRONGLY REDUCE AORTIC VISCO-ELASTIC PROPERTIES IN RATS AT BASAL AND MATCHED BLOOD PRESSURE LEVELS (0)
- Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor. (2012) (0)
- Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy (2016) (0)
- Faculty Opinions recommendation of Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. (2010) (0)
- Su1168 - Microbial Proteases Increase Sensitivity to Dietary Antigen Through Par-2 Signaling (2018) (0)
- P2497Lack of LRP8 on bone marrow derived cells triggers the formation of aortic dissection in angiotensin II infused mice (2018) (0)
- Abstract 70: P2X7-Induced Thiol-Disulfide Exchange is Critical for the Coupling of Coagulation and Inflammation. (2013) (0)
- Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients (2020) (0)
- Identification Of The Coagulation Factor VIIa Integrin Binding Site Essential For Pro-Angiogenic Tissue Factor Signaling (2013) (0)
- Abstract 18216: Essential Role of Platelet Glycoprotein Ibα Dependent Thrombin-FXI Feedback Loop in Arterial Hypertension, Vascular Dysfunction and Inflammation (2015) (0)
- EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR (1998) (0)
- Title: Tissue factor isoforms in cancer and blood coagulation Issue Date: 2015-04-29 Chapter 6-Dual targeting of cancer cell-derived TF isoforms: a new approach to block breast cancer progression (2015) (0)
- A19 BACTERIAL PROTEASES INCREASE SENSITIVITY TO DIETARY ANTIGEN THROUGH PAR-2 SIGNALING (2018) (0)
- Chapter 4 - Splice variants of Tissue Factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin ligation (2013) (0)
- Regulation of Developmental and Pathological Angiogenesis by Tissue Factor Cytoplasmic Domain Signalling (2004) (0)
- 3WS15-5 Coagulation proteases in vascular biology (2003) (0)
- Method for increasing the controllability of a braked vehicle (1988) (0)
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