Xiaowei Zhuang
Chinese biophysicist
Xiaowei Zhuang's AcademicInfluence.com Rankings
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Physics
Xiaowei Zhuang's Degrees
- PhD Physics University of California, Berkeley
- Bachelors Physics University of Science and Technology of China
Why Is Xiaowei Zhuang Influential?
(Suggest an Edit or Addition)According to Wikipedia, Xiaowei Zhuang is a Chinese-American biophysicist who is the David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology, and Professor of Physics at Harvard University, and an Investigator at the Howard Hughes Medical Institute. She is best known for her work in the development of Stochastic Optical Reconstruction Microscopy , a super-resolution fluorescence microscopy method, and the discoveries of novel cellular structures using STORM. She received a 2019 Breakthrough Prize in Life Sciences for developing super-resolution imaging techniques that get past the diffraction limits of traditional light microscopes, allowing scientists to visualize small structures within living cells. She was elected a Member of the American Philosophical Society in 2019 and was awarded a Vilcek Foundation Prize in Biomedical Science in 2020.
Xiaowei Zhuang's Published Works
Published Works
- Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) (2006) (6643)
- Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy (2008) (2421)
- Super-resolution fluorescence microscopy. (2009) (1462)
- Multicolor Super-Resolution Imaging with Photo-Switchable Fluorescent Probes (2007) (1353)
- Spatially resolved, highly multiplexed RNA profiling in single cells (2015) (1327)
- Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging (2011) (1137)
- Electrical detection of single viruses. (2004) (1121)
- Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells (2010) (1008)
- Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons (2013) (1004)
- Visualizing infection of individual influenza viruses (2003) (680)
- Fast three-dimensional super-resolution imaging of live cells (2011) (672)
- Super-resolution imaging reveals distinct chromatin folding for different epigenetic states (2015) (669)
- A single-molecule study of RNA catalysis and folding. (2000) (652)
- Superresolution Imaging of Chemical Synapses in the Brain (2010) (618)
- Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region (2018) (614)
- Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells (2018) (581)
- Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution (2008) (561)
- Ligands for Clathrin-Mediated Endocytosis Are Differentially Sorted into Distinct Populations of Early Endosomes (2006) (551)
- Coupled, Circumferential Motions of the Cell Wall Synthesis Machinery and MreB Filaments in B. subtilis (2011) (489)
- Correlating Structural Dynamics and Function in Single Ribozyme Molecules (2002) (480)
- Spatial organization of chromatin domains and compartments in single chromosomes (2016) (478)
- Assembly of endocytic machinery around individual influenza viruses during viral entry (2004) (457)
- Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells (2008) (446)
- Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeleton (2011) (438)
- Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes (2012) (437)
- Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation (2013) (411)
- Virus trafficking – learning from single-virus tracking (2007) (389)
- Visualizing and discovering cellular structures with super-resolution microscopy (2018) (374)
- Endocytosis of influenza viruses. (2004) (330)
- Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression (2019) (322)
- Short-range spectroscopic ruler based on a single-molecule optical switch. (2005) (320)
- Nanotools for neuroscience and brain activity mapping. (2013) (320)
- Molecular Architecture and Assembly Principles of Vibrio cholerae Biofilms (2012) (320)
- Photoswitching Mechanism of Cyanine Dyes (2009) (315)
- Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria (2011) (315)
- The 2015 super-resolution microscopy roadmap (2015) (300)
- Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes (2015) (299)
- Characterization and development of photoactivatable fluorescent proteins for single-molecule–based superresolution imaging (2014) (298)
- Imaging Poliovirus Entry in Live Cells (2007) (294)
- High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization (2016) (289)
- Isotropic 3D Super-resolution Imaging with a Self-bending Point Spread Function (2013) (269)
- Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells (2016) (261)
- Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan‐Binding Ligands (2007) (258)
- Characterization of the Early Events in Dengue Virus Cell Entry by Biochemical Assays and Single-Virus Tracking (2007) (248)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Ligand-induced conformational changes observed in single RNA molecules. (1999) (230)
- Exploring the folding landscape of a structured RNA (2001) (216)
- Single-molecule transition-state analysis of RNA folding (2003) (203)
- Ultra-bright Photoactivatable Fluorophores Created by Reductive Caging (2012) (200)
- Super-resolution microscopy by nanoscale localization of photo-switchable fluorescent probes. (2008) (199)
- Single-molecule folding. (2003) (197)
- Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin (2020) (195)
- A multimodal cell census and atlas of the mammalian primary motor cortex (2020) (190)
- Dynamic binding orientations direct activity of HIV reverse transcriptase (2008) (187)
- High-performance probes for light and electron microscopy (2015) (186)
- Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus (2008) (186)
- Developmental mechanism of the periodic membrane skeleton in axons (2014) (186)
- Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein (2007) (186)
- High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing (2016) (186)
- Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility (2014) (183)
- Dynamics of nucleosome remodelling by individual ACF complexes (2009) (178)
- Fluorescence quenching: A tool for single-molecule protein-folding study. (2000) (175)
- Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates (2008) (167)
- Nano-imaging with Storm. (2009) (165)
- Statistical deconvolution for superresolution fluorescence microscopy. (2012) (165)
- Single-molecule RNA science. (2005) (158)
- Chromatin topology is coupled to Polycomb group protein subnuclear organization (2016) (157)
- Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy (2017) (150)
- Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distance. (2004) (146)
- Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. (2021) (146)
- A high-density 3D localization algorithm for stochastic optical reconstruction microscopy (2012) (146)
- ISWI Remodelers Slide Nucleosomes with Coordinated Multi-Base-Pair Entry Steps and Single-Base-Pair Exit Steps (2013) (145)
- Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system (2010) (144)
- Multicolor Super-Resolution Fluorescence Imaging via Multi-Parameter Fluorophore Detection (2011) (141)
- Spatial colocalization and functional link of purinosomes with mitochondria (2016) (138)
- Using single-particle tracking to study nuclear trafficking of viral genes. (2004) (129)
- Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram (2021) (126)
- Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species (2016) (124)
- m6A-binding YTHDF proteins promote stress granule formation (2020) (122)
- Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing (2019) (121)
- Spatial organization shapes the turnover of a bacterial transcriptome (2016) (120)
- RNA Imaging with Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH). (2016) (114)
- Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons (2017) (110)
- Mapping Synaptic Input Fields of Neurons with Super-Resolution Imaging (2015) (108)
- Exploration of the transition state for tertiary structure formation between an RNA helix and a large structured RNA. (2003) (106)
- Phosphine quenching of cyanine dyes as a versatile tool for fluorescence microscopy. (2013) (106)
- CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility (2017) (105)
- A model for the generation and interconversion of ER morphologies (2014) (103)
- Sub-Diffraction-Limit Imaging with Stochastic Optical Reconstruction Microscopy (2010) (99)
- Stochastic optical reconstruction microscopy (STORM): a method for superresolution fluorescence imaging. (2013) (93)
- Dual Function of CD81 in Influenza Virus Uncoating and Budding (2013) (91)
- Single-molecule RNA folding. (2005) (90)
- Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH (2021) (90)
- Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic “fingerprinting” (2007) (87)
- Annual review of biophysics (2008) (86)
- 3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing (2012) (85)
- Spatially resolved single-cell genomics and transcriptomics by imaging (2021) (84)
- An RNA-aptamer-based two-color CRISPR labeling system (2016) (82)
- Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA (2014) (81)
- A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport (2014) (79)
- Fast compressed sensing analysis for super-resolution imaging using L1-homotopy. (2013) (77)
- Multiplexed detection of RNA using MERFISH and branched DNA amplification (2018) (75)
- Correlative Stochastic Optical Reconstruction Microscopy and Electron Microscopy (2015) (75)
- Analyzing Single Molecule Localization Microscopy Data Using Cubic Splines (2016) (70)
- Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging (2019) (70)
- Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes (2013) (67)
- Live cell imaging of viral entry (2013) (65)
- Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription (2010) (65)
- Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons (2019) (64)
- Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains (2013) (63)
- Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization (2019) (62)
- Purinosome formation as a function of the cell cycle (2015) (62)
- Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters (2019) (61)
- Unraveling DNA Condensation with Optical Tweezers (2004) (60)
- In Situ Super-Resolution Imaging of Genomic DNA with OligoSTORM and OligoDNA-PAINT. (2017) (56)
- The Human Cell Atlas White Paper (2018) (55)
- Two distinct binding modes of a protein cofactor with its target RNA. (2006) (55)
- Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells (2014) (54)
- Stepwise nucleosome translocation by RSC remodeling complexes (2016) (52)
- CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains (2021) (52)
- Rotation tracking of genome-processing enzymes using DNA origami rotors (2019) (51)
- Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling (2019) (50)
- Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H (2010) (46)
- Dissecting the Role of COPI Complexes in Influenza Virus Infection (2012) (46)
- The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction (2017) (44)
- High-throughput, image-based screening of pooled genetic variant libraries (2017) (42)
- Decoding molecular and cellular heterogeneity of mouse nucleus accumbens (2021) (42)
- Rapid actin-dependent viral motility in live cells. (2009) (42)
- βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport (2019) (38)
- Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration (2019) (38)
- Molecular, spatial and projection diversity of neurons in primary motor cortex revealed by in situ single-cell transcriptomics (2020) (38)
- Functional importance of telomerase pseudoknot revealed by single-molecule analysis (2011) (38)
- Characterizing spatial gene expression heterogeneity in spatially resolved single-cell transcriptomic data with nonuniform cellular densities (2021) (36)
- Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. (2020) (35)
- Deep learning and alignment of spatially-resolved whole transcriptomes of single cells in the mouse brain with Tangram (2020) (34)
- Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria (2018) (34)
- A single-molecule assay for telomerase structure-function analysis (2009) (33)
- Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH (2022) (32)
- Kinetic analysis of sequential multistep reactions. (2007) (31)
- A preoptic neuronal population controls fever and appetite during sickness (2022) (28)
- Building a high-quality Human Cell Atlas (2021) (27)
- Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction (2014) (26)
- Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes (2017) (26)
- New fluorescent probes for super-resolution imaging (2011) (26)
- Robust reconstruction of the rate constant distribution using the phase function method. (2006) (25)
- Prevalent Presence of Periodic Actin-spectrin-based Membrane Skeleton in a Broad Range of Neuronal Cell Types and Animal Species (2016) (24)
- Single-virus tracking in live cells. (2011) (20)
- m6A-binding YTHDF proteins promote stress granule formation by modulating phase separation of stress granule proteins (2019) (20)
- Spatial organization of the transcriptome in individual neurons (2020) (19)
- Spatially resolved epigenomic profiling of single cells in complex tissues (2022) (18)
- Preparation of photoswitchable labeled antibodies for STORM imaging. (2013) (16)
- Monitoring conformational dynamics with single-molecule fluorescence energy transfer: applications in nucleosome remodeling. (2012) (14)
- Fluorescence Imaging at Sub-Diffraction-Limit Resolution with Stochastic Optical Reconstruction Microscopy (2009) (12)
- CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains (2020) (12)
- Tetra-gel enables superior accuracy in combined super-resolution imaging and expansion microscopy (2021) (11)
- Super-Resolution Imaging Through Stochastic Switching and Localization of Single Molecules: An Overview (2013) (10)
- Blind sparse inpainting reveals cytoskeletal filaments with sub-Nyquist localization. (2017) (10)
- Molecular and spatial signatures of mouse brain aging at single-cell resolution (2022) (9)
- Proteomic and functional analyses of the periodic membrane skeleton in neurons (2020) (8)
- A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) (7)
- Voices in methods development (2019) (6)
- Molecular biology: Concealed enzyme coordination (2009) (6)
- Superresolution Imaging of Intact Microbial Communities Reveals Molecular Architecture of Biofilm Development and Bacterial Organization (2011) (5)
- Transfection of genetically encoded photoswitchable probes for STORM imaging. (2013) (5)
- Single-particle virus tracking. (2011) (5)
- Molecular biology. Unraveling DNA condensation with optical tweezers. (2004) (4)
- Author response: Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration (2019) (3)
- Switch and Resolve: Fatigue-resistant Photoswitchable Fluorescent Proteins for Super-resolution Fluorescence Microscopy (2011) (3)
- Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy (2018) (3)
- A molecularly defined and spatially resolved cell atlas of the whole mouse brain (2023) (3)
- Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH (2021) (2)
- Three-dimensional Interrogation of Cell Types and Instinctive Behavior in the Periaqueductal Gray (2022) (2)
- Conservation and divergence in cortical cellular organization between human and mouse revealed by single-cell transcriptome imaging (2021) (2)
- Super-Resolution Fluorescence Imaging with STORM (2013) (2)
- Author Correction: Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy (2018) (2)
- Three-dimensional Super-resolution Fluorescence Microscopy and Its Application to Clathrin Mediated Endocytosis (2009) (1)
- High-throughput, image-based screening of genetic variant libraries (2017) (1)
- Library construction and imaging for high-throughput image-based screening using multiplexed FISH (2017) (1)
- Bioimaging at the Nanoscale: Single-molecule and Super-resolution Fluorescence Microscopy (2012) (1)
- Super-Resolution Imaging Reveals a Multi-Array Arrangement of Catsper Channel on the Sperm Tail (2012) (1)
- Mapping the cellular and molecular organization of mouse cerebral aging by single-cell transcriptome imaging (2022) (1)
- Mapping Neuronal Connectivity Using Stochastic Optical Reconstruction Microscopy (Storm): The Brainstorm Project (2010) (1)
- The Study of Single Biomolecules with Fluorescence Methods (2001) (1)
- NANOSCOPIC IMAGING OF BIOMOLECULES AND CELLS WITH STORM (2008) (0)
- Author response: Stepwise nucleosome translocation by RSC remodeling complexes (2015) (0)
- Exploring the folding landscc (2016) (0)
- New technologies. Editorial overview (2010) (0)
- Rotation Tracking Using DNA Origami Rotors Reveals Single Base Pair Steps During Transcription by RNA Polymerase (2021) (0)
- A tale of two reverse transcriptases – assembly, structural dynamics and function of telomerase and HIV reverse transcriptase (2008) (0)
- Imaging & Optical Microscopy III (2009) (0)
- Nanoscopic Imaging of Biomolecules, Cells and Tissues with STORM (2008) (0)
- Single-Molecule Studies of Nucleosome Translocation by the ACF Chromatin Remodeling Complex (2013) (0)
- Webinar: Super-Resolution Imaging of Neurons (2014) (0)
- Reductive Caging enables Ultra-Bright Photoactivatable Fluorophores for Superresolution Imaging (2013) (0)
- Illuminating biology at the nanoscale with single-molecule and super-resolution fluorescence microscopy (2016) (0)
- Nucleosome Sliding by ACF is Processive and Bidirectional (2009) (0)
- MERFISH - Tissue Processing v1 (0)
- Abstract 2592: Host dependency factors for binding and internalization of oncolytic Seneca Valley Virus (2010) (0)
- Dynamics of the HIV Reverse Transcription Initiation Complex (2010) (0)
- Tetra-gel expansion microscopy combined with superresolution imaging enables superior accuracy (2022) (0)
- Multicolor Three-dimensional Whole-cell Imaging With Nanometer Scale Resolution (2009) (0)
- Super-Resolution Imaging Of Chromatin Organization in Individual Chromosomes (2017) (0)
- Conformation of Telomerase RNP Established through Footprinting and Single-Molecule FRET (2009) (0)
- High resolution optical microscopy analysis of Influenza Virus A assembly (2009) (0)
- Frontiers in Laser Cooling, Single-Molecule Biophysics, and Enrgy Science: A Talk from Taekjip Ha and Xiaowei Zhuang (2008) (0)
- TAMI-12. CANCER-IMMUNE CELL INTERACTIONS DRIVE TRANSITIONS TO MESENCHYMAL-LIKE STATES IN GLIOBLASTOMA (2021) (0)
- Structurally Distinct Ca2+ Domains of Sperm Flagella Modulate Hyperactivated Motility (2014) (0)
- Analyzing Single Molecule Localization Microscopy Data Using Cubic Splines (2017) (0)
- Author Correction: Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy (2018) (0)
- Structural and Functional Dynamics of Nucleic-acid Interacting Enzymes Studied by Single-molecule FRET (2009) (0)
- OTME-7. Cancer - immune cell interactions drive transitions to mesenchymal-like state in glioblastoma (2021) (0)
- MERFISH - Preparation of Encoding Probes v1 (2020) (0)
- 636 a Wednesday , March 4 , 2009 Imaging & Optical Microscopy III (2009) (0)
- Abstract IA13: Super-resolution fluorescence microscopy of cells and tissues (2012) (0)
- High-Resolution Single Molecule Rotation Tracking of RecBCD using DNA Origami Rotors (2017) (0)
- MERFISH Protocols for HTAPP v1 (0)
- Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling (2019) (0)
- Sparse Statistical Deconvolution for High-Density Localization Microscopy (2012) (0)
- Watching the Motions of the Cell Wall Synthesis Machinery and Underlying Cytoskeleton in B. Subtilis (2012) (0)
- New technologies (2010) (0)
- Catsper Channel Organizes and Regulates Calcium Signaling Molecules in Spermatozoa (2013) (0)
- JCB_201407063 1..18 (2014) (0)
- Caught in the Act: Single Molecule Structure-Function Studies of Telomerase (2009) (0)
- Illuminating biology at the nanoscale with single‐molecule and super‐resolution imaging (2016) (0)
- Live-Cell Super-Resolution Fluorescence Imaging at High Spatiotemporal Resolutions (2012) (0)
- Retrovirus Replication: New Perspectives on Enzyme and Substrate Dynamics (2010) (0)
- High-throughput Rotation Tracking using DNA Origami Rotors (2018) (0)
- Platform: Imaging & Optical Microscopy: Cell & Tissue Imaging (2012) (0)
- Max Delbruck Prize in Biological Physics Talk: Zoom into life at the nanoscale with STORM (2011) (0)
- Abstract PD6-03: Spatio-molecular dissection of the breast cancer metastatic microenvironment (2022) (0)
- Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF) (2023) (0)
- Multiplexed detection of RNA using MERFISH and branched DNA amplification (2019) (0)
- Spatially resolved single-cell genomics and transcriptomics by imaging (2021) (0)
- EMBO / EMBL Symposium - Seeing is Believing: Submit your Abstract by 10th July (2015) (0)
- Observing folding and catalysis of a single RNA enzyme molecule (2000) (0)
- Single-Molecule Analysis of the Functional Structure of Telomerase RNP (2012) (0)
- Visualizing Cellular Entry of Individual Virus Particles (2006) (0)
- Structural Studies by Correlative Stochastic Optical Reconstruction Microscopy and Electron Microscopy (2014) (0)
- MERFISH - Imaging v1 (2020) (0)
- Single‐Molecule RNA Folding (2005) (0)
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What Schools Are Affiliated With Xiaowei Zhuang?
Xiaowei Zhuang is affiliated with the following schools: