Yoshio Imai
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Yoshio Imaibiology Degrees
Biology
#13436
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#16981
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Biochemistry
#2353
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#2502
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Biology
Yoshio Imai's Degrees
- PhD Biochemistry University of Tokyo
Why Is Yoshio Imai Influential?
(Suggest an Edit or Addition)Yoshio Imai's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. (1966) (721)
- A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes. (1971) (323)
- A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits. (1974) (252)
- Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes. (1966) (234)
- Substrate interaction with hydroxylase system in liver microsomes. (1966) (168)
- Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. (1979) (145)
- Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes (1996) (129)
- Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity. (1992) (125)
- Conversion of P-450 to P-420 by neutral salts and some other reagents. (1967) (124)
- Evidence for two forms of P-450 hemoprotein in microsomal membranes. (1966) (114)
- Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits. (1976) (112)
- Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties. (1980) (105)
- Studies on the substrate interactions with P-450 in drug hydroxylation by liver microsomes. (1967) (101)
- An affinity column method for partial purification of cytochrome P-450 from phenobarbital-induced rabbit liver microsomes. (1974) (92)
- The use of 8-aminooctyl sepharose for the separation of some components of the hepatic microsomal electron transfer system. (1976) (85)
- The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450. (1977) (84)
- Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against gram-negative bacteria. (1999) (77)
- Genetic studies on induced and spontaneous hypercholesterolemia in rats. (1973) (62)
- Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopy. (1997) (62)
- The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450. (1981) (61)
- Studies on the microsomal mixed function oxidase system: redox properties of detergent-solubilized NADPH-cytochrome P-450 reductase. (1978) (60)
- Activation and inhibition of microsomal hydroxylation by ethyl isocyanide. (1966) (60)
- Anomalous spectral interactions of reduced P-450 with ethyl isocyanide and other lipophilic ligands. (1967) (59)
- Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase) (1989) (59)
- Serum and tissue lipids and glomerulonephritis in the spontaneously hypercholesterolemic (SHC) rat, with a note on the effects of gonadectomy. (1977) (52)
- Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450. (1984) (52)
- Hepatic mitochondrial cytochrome P-450: isolation and functional characterization. (1977) (50)
- Rate-limiting step in the reconstituted microsomal drug hydroxylase system. (1977) (48)
- Magnetic circular dichroism studies of hepatic microsomal cytochrome P-450. (1975) (48)
- Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes. (1996) (48)
- Solubilization of aromatic hydroxylase system of liver microsomes and requirement of lipid-like factor. (1960) (48)
- Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity. (1993) (44)
- Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo. (1992) (44)
- Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450. (1979) (41)
- Studies on the lipogenesis in animal tissues under pathological conditions. I. The formation of unsaturated fatty acid in diabetic and fasted rats. (1961) (39)
- Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1. (1994) (39)
- Hypocholesterolemic effect of alisol A-24-monoacetate and its related compounds in rats. (1970) (36)
- Resonance Raman studies of hepatic microsomal cytochromes P-450: evidence for strong pi basicity of the fifth ligand in the reduced and carbonyl complex forms. (1978) (36)
- Characterization of rabbit liver cytochrome P-450 (laurate omega-1 hydroxylase) synthesized in transformed yeast cells. (1988) (34)
- Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. (2008) (34)
- Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. II. Spectral properties. (1980) (34)
- Purification and characterization of recombinant human prostacyclin synthase. (2004) (33)
- The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis (1988) (33)
- Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. (1990) (33)
- Circular dichroism of cytochrome cc' and cytochrome c'. (1969) (31)
- Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits. (1988) (30)
- Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells. (1987) (30)
- Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins. (1997) (29)
- Partial purification and some spectral properties of hepatic microsomal cytochrome P-450. (1973) (28)
- Site of biosynthesis of cytochrome P450 in hepatocytes of phenobarbital treated rats. (1976) (28)
- Site-directed mutagenesis of the conserved threonine (Thr243) of the distal helix of fungal cytochrome P450nor. (1998) (26)
- Protein-protein and lipid-protein interactions in a reconstituted cytochrome P-450 dependent microsomal monooxygenase. (1987) (26)
- Biological studies of cholestane-3β,5α,6β-triol and its derivatives: Part 1. Hypocholesterolemic effects in rabbits, chickensd rats on atherogenic diets (1967) (26)
- Reduction of tertiary amine N-oxide by purified cytochrome P-450. (1977) (23)
- Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450. (1981) (23)
- Substrate binding site of microsomal cytochrome P-450 directly faces membrane lipids. (1984) (22)
- Spectrophotometric examination of exogenous-ligand complexes of ferric cytochrome P-450. Characterization of the axial ligand trans to thiolate in the native ferric low-spin form. (1982) (22)
- Identification of regions functioning in substrate interaction of rabbit liver cytochrome P-450 (laurate (omega-1)-hydroxylase). (1989) (21)
- Unique Heme Environment at the Putative Distal Region of Hydrogen Peroxide-Dependent Fatty Acid α-Hydroxylase from Sphingomonas paucimobilis (Peroxygenase P450SPα) (2000) (21)
- Microheterogeneity in the major phenobarbital-inducible forms of rabbit liver microsomal cytochrome P-450 as revealed by nucleotide sequencing of cloned cDNAs. (1988) (20)
- Further purification, characterization and salt activation of acyl-CoA synthetase from Escherichia coli. (1985) (19)
- Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (ω-1)-hydroxylase) with those of P-450 (testosterone 16α-hydroxylase) produces a new stereospecific hydroxylase activity (1990) (18)
- Circular dichroism spectra of purified cytochromes P-450 from rabbit liver microsomes. (1979) (17)
- Importance of an acetone-soluble fraction in aromatic hydroxylation by liver microsomes. (1959) (17)
- Biological studies of cholestane-3β,5α,6β-triol and its derivatives (1967) (16)
- Fungal P450nor: expression in Escherichia coli and site-directed mutageneses at the putative distal region. (1997) (15)
- Three spectrally different states of cytochromes cc' and c' and their interconversion. (1969) (15)
- Growth inhibition of melanoma cells by N-protected dopa derivatives. (1987) (15)
- Changes in plasma lipids and abnormal lipoproteins in a patient with drug-induced cholestatic hepatitis. (1991) (15)
- Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s. (1992) (15)
- Changes in the profiles of rodent plasma lipoproteins and apolipoproteins after cholesterol feeding. (1983) (14)
- Interaction of polycyclic hydrocarbons with cytochrome P-450. I. Specific binding of various hydrocarbons to P-448(1). (1982) (14)
- Formation rates of the two ethyl isocyanide compounds of liver cytochrome P-450 at low temperatures. (1971) (14)
- Transport of fatty acid is obligatory coupled with H+ entry in spheroplasts of Escherichia coli K12. (1987) (14)
- Spectral interactions of protoheme with ethyl isocyanide and some other ligands in enutral pH region. (1968) (14)
- Purification and characterization of cytochrome P-450 with high affinity for 7-alkoxycoumarins. (1984) (13)
- Effect of ionic strength on the ethyl isocyanide difference spectrum of reduced P-450 in liver microsomes. (1968) (13)
- Induction by phenobarbital of hepatic microsomal drug-metabolizing enzyme system in partially hepatectomized rats. (1974) (13)
- Interaction of polycyclic hydrocarbons with cytochrome P-450. III. Effects of hydrocarbon binding on the interaction of some ligands with P-448(1) heme. (1982) (13)
- Biosynthesis of myo-inositol in the rat. (1963) (12)
- Nitrogenous ligation at the sixth coordination position of the Thr-301 to Lys-mutated P450IIC2 heme iron. (1991) (11)
- Dual effect of ethyl isocyanide on drug hydroxylation by liver microsomes. (1968) (11)
- Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid. (1977) (11)
- Characterization of rabbit liver P450IIE1 synthesized in transformed yeast cells. (1990) (10)
- BIOLOGIC STUDIES OF CHOLESTANE-3β,5α,6β-TRIOL AND ITS DERIVATIVES. III. THE METABOLIC FATE AND METABOLITES OF CHOLESTANE-3β,5α,6β-TRIOL IN ANIMALS (1968) (10)
- Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. (1973) (9)
- Isolation and characterization of the multiple charge isoforms of acyl-CoA synthetase from Escherichia coli. (1985) (9)
- Purification and characterization of a form of P450 from horse liver microsomes. (1993) (9)
- Hypotensive Effect of N-Ethoxycarbonyl-3-morpholinosydnonimine(SIN-10) in Carbon Tetrachloride-Treated Rats (1975) (9)
- Distribution of lipids in subcellular fractions of fatty livers. I. Lipids in liver cell fractions of rats fed a high fat and cholesterol diet. (1966) (8)
- Elucidation of the Differences between the 430- and 455-nm Absorbing Forms of P450-Isocyanide Adducts by Resonance Raman Spectroscopy* (2001) (8)
- Importance of successive prolines in the carboxy-terminal region of P450 2C2 and P450 2C14 for the hydroxylase activities. (1993) (8)
- Behavior of two states of the ethyl isocyanide compound of reduced P-450 in oxidation-reduction cycle. (1968) (8)
- Increase of serum high density lipoprotein with progression and regression of aortic lipid deposition in rats. (1979) (8)
- Absorption spectral studies on heme ligand interactions of P-450nor. (1997) (8)
- Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1, 2, 4-Oxadiazole Derivatives. (2) (1973) (7)
- Biological studies of AT-308. 2. Hypocholesterolemic effect of AT-308, a new derivative of 1,2,4-oxadiazole, in rats. (1973) (7)
- Comparison of heme environment at the putative distal region of P-450s utilizing their external and internal nitrogenous ligand bound forms. (1994) (7)
- Hypocholesterolemic effect of surfactin,a novel bacterial peptidelipid (1971) (7)
- Inhibitory effect of bisbenzylisoquinoline alkaloids on the quick death of mice treated with BCG/LPS. (1990) (7)
- Metabolism of 4-methyl-5-β-hydroxyethylthiazole-S35 in rats. (1960) (7)
- Structure-Function Relationships of Cytochrome P-450 Laurate (ω-1)-Hydroxylase (1989) (6)
- Hypercholesterolemia in ExHC rats and lipid-lowering drug: a screening method for new hypocholesterolemic agents. (1981) (5)
- Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes. (1980) (5)
- Suppression of lipoprotein lipase in 3T3-L1 cells by a mediator produced by SEKI melanoma, a cachexia-inducing human melanoma cell line. (1991) (5)
- Interaction of polycyclic hydrocarbons with cytochrome P-450. II. Flash photolysis studies on various hydrocarbon-bound P-448(1) CO compounds. (1982) (5)
- Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). (1989) (5)
- Resonance Raman study on mutant cytochrome P-450 obtained by site-directed mutagenesis. (1990) (4)
- PROTEIN-PROTEIN AND LIPID-PROTEIN INTERACTIONS IN A RECONSTITUTED LIVER MICROSOMAL MONOOXYGENASE SYSTEM (1980) (4)
- 2-AMINO-4-PHENYLTHIAZOLE DERIVATIVES AS ANTI-ATHEROGENIC AGENTS (1981) (4)
- The importance of threonine-301 from cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase) in substrate binding as demonstrated by site-directed mutagenesis. (1988) (4)
- Biologic studies of cholestane-3-beta,5-alpha,6-beta-triol and its derivatives. 3. The metabolic fate and metabolites of cholestane-3-beta,5-alpha,6-beta-triol in animals. (1968) (3)
- Proton correlation NMR studies of metabolism in Rhodopseudomonas palustris. (1984) (3)
- Formation of monounsaturated fatty acids in fatty liver. (1967) (2)
- Biological studies of AT-308-3-Fffect of AT-308,a new derivative of 1,2,4-oxadiazole,on atherosclerosis in cholesterol-fed rabbits (1973) (2)
- BIOSYNTHESIS OF MYO-INOSITOL IN RAT SEMINAL VESICLES AND PROSTATES. (1964) (2)
- Structure-function relationships of cytochrome P-450 laurate (omega-1)-hydroxylase. (1989) (2)
- Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (omega-1)-hydroxylase) with those of P-450 (testosterone 16 alpha-hydroxylase) produces a new stereospecific hydroxylase activity. (1990) (2)
- Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation (1968) (2)
- Further observations on the antiscorbutic activity of O-benzoyl derivatives of L-ascorbic acid in guinea pigs. (1967) (2)
- Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (peroxygenase P450(SPalpha). (2000) (1)
- BIOLOGICAL STUDIES OF CHOLESTANE-3β 5α, 6βTRIOL AND ITS DERIVATIVES: IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS (1967) (0)
- Effect of Cold Exposure on the Labeling of Lipids in Hamster Liver Slices (1960) (0)
- Part 1. HYPOCHOLESTEROLEMIC EFFECT OF 1,2,4-ox.4DIAzoLE DERIVATIVES IN RATS (1973) (0)
- Resonance Raman Studies of Bovine Soluble Guanylate Cyclase (1997) (0)
- ExHC rat: An Animal Model for Hypercholesterolemia (1983) (0)
- Morphological and enzymatic alterations in the rat liver caused by administration of a hypocholesterolemic agent AT-308 and its related compounds. (1978) (0)
- [Gastrointestinal bleeding due to jejunal metastasis of lung cancer contiguous to an emphysematous bulla]. (1993) (0)
- S24 PROTEIN ENGINEERING IN STUDIES ON METABOLISH OF TOXIC SUBSTANCES (1988) (0)
- [Therapeutical effect of active vitamin D metabolites in hypoparathyroidism]. (1982) (0)
- BIOLOGICAL STUDIES OF CHOLESTANE-3, 5a, 6-TRIOL AND ITS DERIVATIVES (1967) (0)
- INFLUENCE OF LACTOSE ON AMOUNT OF LIVER-FAT IN FATTY LIVERS. (1964) (0)
- Laminar Development of R. Entorhinalis in the Brain of Human Embryos (between 20-21 Weeks of Fetal Age) (1961) (0)
- MICROCIRCULATORY RESPONSE TO KETAMINE HCL ANESTHESIA IN THE RAT (1972) (0)
- Protein engineering in studies on metabolism of toxic substances. (1988) (0)
- SYNTHESES OF 2- AND 3-ISOPROPYL-1-METHYLNAPHTHALENES FROM CYCLIC β- AND Γ-KETO ESTERS (1980) (0)
- STUDIES ON THE SYNTHESES OF N‐HETEROCYCLIC COMPOUNDS PART 4, HYPOCHOLESTEROLEMIC 1,2,4‐OXADIAZOLE DERIVATIVES (2) (1973) (0)
- Biological studies of cholestane-3beta,5alpha,6beta-triol and its derivatives. 1. Hypocholesterolemic effects in rabbits, chickens and rats on atherogenic diets. (1967) (0)
- Effect of alisol A-24-monoacetate on the intestinal absorption of cholesterol and fatty acids in rats (1970) (0)
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