Yoshio Imai

Yoshio Imai's AcademicInfluence.com Rankings

Yoshio Imai

Biology

#13436

World Rank

#16981

Historical Rank

Biochemistry

#2353

World Rank

#2502

Historical Rank

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Biology

Yoshio Imai's Degrees

PhD Biochemistry University of Tokyo

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Yoshio Imai's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. (1966) (721)
A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes. (1971) (323)
A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits. (1974) (252)
Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes. (1966) (234)
Substrate interaction with hydroxylase system in liver microsomes. (1966) (168)
Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. (1979) (145)
Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes (1996) (129)
Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity. (1992) (125)
Conversion of P-450 to P-420 by neutral salts and some other reagents. (1967) (124)
Evidence for two forms of P-450 hemoprotein in microsomal membranes. (1966) (114)
Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits. (1976) (112)
Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties. (1980) (105)
Studies on the substrate interactions with P-450 in drug hydroxylation by liver microsomes. (1967) (101)
An affinity column method for partial purification of cytochrome P-450 from phenobarbital-induced rabbit liver microsomes. (1974) (92)
The use of 8-aminooctyl sepharose for the separation of some components of the hepatic microsomal electron transfer system. (1976) (85)
The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450. (1977) (84)
Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against gram-negative bacteria. (1999) (77)
Genetic studies on induced and spontaneous hypercholesterolemia in rats. (1973) (62)
Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopy. (1997) (62)
The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450. (1981) (61)
Studies on the microsomal mixed function oxidase system: redox properties of detergent-solubilized NADPH-cytochrome P-450 reductase. (1978) (60)
Activation and inhibition of microsomal hydroxylation by ethyl isocyanide. (1966) (60)
Anomalous spectral interactions of reduced P-450 with ethyl isocyanide and other lipophilic ligands. (1967) (59)
Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase) (1989) (59)
Serum and tissue lipids and glomerulonephritis in the spontaneously hypercholesterolemic (SHC) rat, with a note on the effects of gonadectomy. (1977) (52)
Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450. (1984) (52)
Hepatic mitochondrial cytochrome P-450: isolation and functional characterization. (1977) (50)
Rate-limiting step in the reconstituted microsomal drug hydroxylase system. (1977) (48)
Magnetic circular dichroism studies of hepatic microsomal cytochrome P-450. (1975) (48)
Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes. (1996) (48)
Solubilization of aromatic hydroxylase system of liver microsomes and requirement of lipid-like factor. (1960) (48)
Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity. (1993) (44)
Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo. (1992) (44)
Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450. (1979) (41)
Studies on the lipogenesis in animal tissues under pathological conditions. I. The formation of unsaturated fatty acid in diabetic and fasted rats. (1961) (39)
Different mechanisms of regioselection of fatty acid hydroxylation by laurate (omega-1)-hydroxylating P450s, P450 2C2 and P450 2E1. (1994) (39)
Hypocholesterolemic effect of alisol A-24-monoacetate and its related compounds in rats. (1970) (36)
Resonance Raman studies of hepatic microsomal cytochromes P-450: evidence for strong pi basicity of the fifth ligand in the reduced and carbonyl complex forms. (1978) (36)
Characterization of rabbit liver cytochrome P-450 (laurate omega-1 hydroxylase) synthesized in transformed yeast cells. (1988) (34)
Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. (2008) (34)
Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. II. Spectral properties. (1980) (34)
Purification and characterization of recombinant human prostacyclin synthase. (2004) (33)
The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis (1988) (33)
Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. (1990) (33)
Circular dichroism of cytochrome cc' and cytochrome c'. (1969) (31)
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits. (1988) (30)
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells. (1987) (30)
Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins. (1997) (29)
Partial purification and some spectral properties of hepatic microsomal cytochrome P-450. (1973) (28)
Site of biosynthesis of cytochrome P450 in hepatocytes of phenobarbital treated rats. (1976) (28)
Site-directed mutagenesis of the conserved threonine (Thr243) of the distal helix of fungal cytochrome P450nor. (1998) (26)
Protein-protein and lipid-protein interactions in a reconstituted cytochrome P-450 dependent microsomal monooxygenase. (1987) (26)
Biological studies of cholestane-3β,5α,6β-triol and its derivatives: Part 1. Hypocholesterolemic effects in rabbits, chickensd rats on atherogenic diets (1967) (26)
Reduction of tertiary amine N-oxide by purified cytochrome P-450. (1977) (23)
Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450. (1981) (23)
Substrate binding site of microsomal cytochrome P-450 directly faces membrane lipids. (1984) (22)
Spectrophotometric examination of exogenous-ligand complexes of ferric cytochrome P-450. Characterization of the axial ligand trans to thiolate in the native ferric low-spin form. (1982) (22)
Identification of regions functioning in substrate interaction of rabbit liver cytochrome P-450 (laurate (omega-1)-hydroxylase). (1989) (21)
Unique Heme Environment at the Putative Distal Region of Hydrogen Peroxide-Dependent Fatty Acid α-Hydroxylase from Sphingomonas paucimobilis (Peroxygenase P450SPα) (2000) (21)
Microheterogeneity in the major phenobarbital-inducible forms of rabbit liver microsomal cytochrome P-450 as revealed by nucleotide sequencing of cloned cDNAs. (1988) (20)
Further purification, characterization and salt activation of acyl-CoA synthetase from Escherichia coli. (1985) (19)
Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (ω-1)-hydroxylase) with those of P-450 (testosterone 16α-hydroxylase) produces a new stereospecific hydroxylase activity (1990) (18)
Circular dichroism spectra of purified cytochromes P-450 from rabbit liver microsomes. (1979) (17)
Importance of an acetone-soluble fraction in aromatic hydroxylation by liver microsomes. (1959) (17)
Biological studies of cholestane-3β,5α,6β-triol and its derivatives (1967) (16)
Fungal P450nor: expression in Escherichia coli and site-directed mutageneses at the putative distal region. (1997) (15)
Three spectrally different states of cytochromes cc' and c' and their interconversion. (1969) (15)
Growth inhibition of melanoma cells by N-protected dopa derivatives. (1987) (15)
Changes in plasma lipids and abnormal lipoproteins in a patient with drug-induced cholestatic hepatitis. (1991) (15)
Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s. (1992) (15)
Changes in the profiles of rodent plasma lipoproteins and apolipoproteins after cholesterol feeding. (1983) (14)
Interaction of polycyclic hydrocarbons with cytochrome P-450. I. Specific binding of various hydrocarbons to P-448(1). (1982) (14)
Formation rates of the two ethyl isocyanide compounds of liver cytochrome P-450 at low temperatures. (1971) (14)
Transport of fatty acid is obligatory coupled with H+ entry in spheroplasts of Escherichia coli K12. (1987) (14)
Spectral interactions of protoheme with ethyl isocyanide and some other ligands in enutral pH region. (1968) (14)
Purification and characterization of cytochrome P-450 with high affinity for 7-alkoxycoumarins. (1984) (13)
Effect of ionic strength on the ethyl isocyanide difference spectrum of reduced P-450 in liver microsomes. (1968) (13)
Induction by phenobarbital of hepatic microsomal drug-metabolizing enzyme system in partially hepatectomized rats. (1974) (13)
Interaction of polycyclic hydrocarbons with cytochrome P-450. III. Effects of hydrocarbon binding on the interaction of some ligands with P-448(1) heme. (1982) (13)
Biosynthesis of myo-inositol in the rat. (1963) (12)
Nitrogenous ligation at the sixth coordination position of the Thr-301 to Lys-mutated P450IIC2 heme iron. (1991) (11)
Dual effect of ethyl isocyanide on drug hydroxylation by liver microsomes. (1968) (11)
Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid. (1977) (11)
Characterization of rabbit liver P450IIE1 synthesized in transformed yeast cells. (1990) (10)
BIOLOGIC STUDIES OF CHOLESTANE-3β,5α,6β-TRIOL AND ITS DERIVATIVES. III. THE METABOLIC FATE AND METABOLITES OF CHOLESTANE-3β,5α,6β-TRIOL IN ANIMALS (1968) (10)
Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. (1973) (9)
Isolation and characterization of the multiple charge isoforms of acyl-CoA synthetase from Escherichia coli. (1985) (9)
Purification and characterization of a form of P450 from horse liver microsomes. (1993) (9)
Hypotensive Effect of N-Ethoxycarbonyl-3-morpholinosydnonimine(SIN-10) in Carbon Tetrachloride-Treated Rats (1975) (9)
Distribution of lipids in subcellular fractions of fatty livers. I. Lipids in liver cell fractions of rats fed a high fat and cholesterol diet. (1966) (8)
Elucidation of the Differences between the 430- and 455-nm Absorbing Forms of P450-Isocyanide Adducts by Resonance Raman Spectroscopy* (2001) (8)
Importance of successive prolines in the carboxy-terminal region of P450 2C2 and P450 2C14 for the hydroxylase activities. (1993) (8)
Behavior of two states of the ethyl isocyanide compound of reduced P-450 in oxidation-reduction cycle. (1968) (8)
Increase of serum high density lipoprotein with progression and regression of aortic lipid deposition in rats. (1979) (8)
Absorption spectral studies on heme ligand interactions of P-450nor. (1997) (8)
Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1, 2, 4-Oxadiazole Derivatives. (2) (1973) (7)
Biological studies of AT-308. 2. Hypocholesterolemic effect of AT-308, a new derivative of 1,2,4-oxadiazole, in rats. (1973) (7)
Comparison of heme environment at the putative distal region of P-450s utilizing their external and internal nitrogenous ligand bound forms. (1994) (7)
Hypocholesterolemic effect of surfactin,a novel bacterial peptidelipid (1971) (7)
Inhibitory effect of bisbenzylisoquinoline alkaloids on the quick death of mice treated with BCG/LPS. (1990) (7)
Metabolism of 4-methyl-5-β-hydroxyethylthiazole-S35 in rats. (1960) (7)
Structure-Function Relationships of Cytochrome P-450 Laurate (ω-1)-Hydroxylase (1989) (6)
Hypercholesterolemia in ExHC rats and lipid-lowering drug: a screening method for new hypocholesterolemic agents. (1981) (5)
Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes. (1980) (5)
Suppression of lipoprotein lipase in 3T3-L1 cells by a mediator produced by SEKI melanoma, a cachexia-inducing human melanoma cell line. (1991) (5)
Interaction of polycyclic hydrocarbons with cytochrome P-450. II. Flash photolysis studies on various hydrocarbon-bound P-448(1) CO compounds. (1982) (5)
Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). (1989) (5)
Resonance Raman study on mutant cytochrome P-450 obtained by site-directed mutagenesis. (1990) (4)
PROTEIN-PROTEIN AND LIPID-PROTEIN INTERACTIONS IN A RECONSTITUTED LIVER MICROSOMAL MONOOXYGENASE SYSTEM (1980) (4)
2-AMINO-4-PHENYLTHIAZOLE DERIVATIVES AS ANTI-ATHEROGENIC AGENTS (1981) (4)
The importance of threonine-301 from cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase) in substrate binding as demonstrated by site-directed mutagenesis. (1988) (4)
Biologic studies of cholestane-3-beta,5-alpha,6-beta-triol and its derivatives. 3. The metabolic fate and metabolites of cholestane-3-beta,5-alpha,6-beta-triol in animals. (1968) (3)
Proton correlation NMR studies of metabolism in Rhodopseudomonas palustris. (1984) (3)
Formation of monounsaturated fatty acids in fatty liver. (1967) (2)
Biological studies of AT-308-3-Fffect of AT-308,a new derivative of 1,2,4-oxadiazole,on atherosclerosis in cholesterol-fed rabbits (1973) (2)
BIOSYNTHESIS OF MYO-INOSITOL IN RAT SEMINAL VESICLES AND PROSTATES. (1964) (2)
Structure-function relationships of cytochrome P-450 laurate (omega-1)-hydroxylase. (1989) (2)
Replacing the carboxy-terminal 28 residues of rabbit liver P-450 (laurate (omega-1)-hydroxylase) with those of P-450 (testosterone 16 alpha-hydroxylase) produces a new stereospecific hydroxylase activity. (1990) (2)
Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation (1968) (2)
Further observations on the antiscorbutic activity of O-benzoyl derivatives of L-ascorbic acid in guinea pigs. (1967) (2)
Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (peroxygenase P450(SPalpha). (2000) (1)
BIOLOGICAL STUDIES OF CHOLESTANE-3β 5α, 6βTRIOL AND ITS DERIVATIVES: IV. ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF CHOLESTANE-3β, 5α, 6β-TRIOL AND ITS DERIVATIVES IN MICE, RATS, DOGS AND MONKEYS (1967) (0)
Effect of Cold Exposure on the Labeling of Lipids in Hamster Liver Slices (1960) (0)
Part 1. HYPOCHOLESTEROLEMIC EFFECT OF 1,2,4-ox.4DIAzoLE DERIVATIVES IN RATS (1973) (0)
Resonance Raman Studies of Bovine Soluble Guanylate Cyclase (1997) (0)
ExHC rat: An Animal Model for Hypercholesterolemia (1983) (0)
Morphological and enzymatic alterations in the rat liver caused by administration of a hypocholesterolemic agent AT-308 and its related compounds. (1978) (0)
[Gastrointestinal bleeding due to jejunal metastasis of lung cancer contiguous to an emphysematous bulla]. (1993) (0)
S24 PROTEIN ENGINEERING IN STUDIES ON METABOLISH OF TOXIC SUBSTANCES (1988) (0)
[Therapeutical effect of active vitamin D metabolites in hypoparathyroidism]. (1982) (0)
BIOLOGICAL STUDIES OF CHOLESTANE-3, 5a, 6-TRIOL AND ITS DERIVATIVES (1967) (0)
INFLUENCE OF LACTOSE ON AMOUNT OF LIVER-FAT IN FATTY LIVERS. (1964) (0)
Laminar Development of R. Entorhinalis in the Brain of Human Embryos (between 20-21 Weeks of Fetal Age) (1961) (0)
MICROCIRCULATORY RESPONSE TO KETAMINE HCL ANESTHESIA IN THE RAT (1972) (0)
Protein engineering in studies on metabolism of toxic substances. (1988) (0)
SYNTHESES OF 2- AND 3-ISOPROPYL-1-METHYLNAPHTHALENES FROM CYCLIC β- AND Γ-KETO ESTERS (1980) (0)
STUDIES ON THE SYNTHESES OF N‐HETEROCYCLIC COMPOUNDS PART 4, HYPOCHOLESTEROLEMIC 1,2,4‐OXADIAZOLE DERIVATIVES (2) (1973) (0)
Biological studies of cholestane-3beta,5alpha,6beta-triol and its derivatives. 1. Hypocholesterolemic effects in rabbits, chickens and rats on atherogenic diets. (1967) (0)
Effect of alisol A-24-monoacetate on the intestinal absorption of cholesterol and fatty acids in rats (1970) (0)

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What Schools Are Affiliated With Yoshio Imai?

Yoshio Imai is affiliated with the following schools:

Osaka University