Yasuo Ihara

Q: What Schools Are Affiliated With Yasuo Ihara

Yasuo Ihara is affiliated with the following schools: University of Tokyo, University of California, San Diego, Doshisha University

Yasuo Ihara's AcademicInfluence.com Rankings

Yasuo Ihara

Biology

#8378

World Rank

#11446

Historical Rank

Biochemistry

#1210

World Rank

#1329

Historical Rank

biology Degrees

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Biology

Yasuo Ihara's Degrees

PhD Biochemistry University of Tokyo
Masters Biochemistry University of Tokyo
Bachelors Biochemistry University of Tokyo

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Yasuo Ihara's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) (1994) (1560)
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. (1993) (1392)
Ubiquitin is a component of paired helical filaments in Alzheimer's disease. (1987) (703)
The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein (1991) (664)
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). (1994) (567)
Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*) (1995) (555)
Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' (1998) (548)
Dominant and differential deposition of distinct β-amyloid peptide species, Aβ N3(pE), in senile plaques (1995) (515)
Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. (1986) (489)
GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease (1995) (414)
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease (2005) (391)
Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. (1982) (381)
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain. (1992) (372)
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment (2009) (351)
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA (1989) (347)
One of the antigenic determinants of paired helical filaments is related to tau protein. (1986) (341)
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome (1995) (336)
Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase (2005) (331)
Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease (1988) (318)
Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42* (1997) (316)
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments (1993) (306)
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch* (2001) (293)
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. (2000) (289)
Potent amyloidogenicity and pathogenicity of Aβ43 (2011) (252)
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins (1983) (245)
The car☐yl third of tau is tightly bound to paired helical filaments (1988) (229)
Hyperphosphorylation of Tau in PHF (1995) (229)
In vivo phosphorylation sites in fetal and adult rat tau. (1993) (227)
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. (1994) (216)
Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. (1982) (210)
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. (1995) (195)
Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments (1992) (194)
τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ (1993) (194)
Lewy bodies are ubiquitinated (1988) (192)
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. (1996) (187)
Molecular cloning of human growth inhibitory factor cDNA and its down‐regulation in Alzheimer's disease. (1992) (187)
Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules* (2000) (179)
Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (2000) (173)
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. (2005) (168)
Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein (1996) (165)
Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer’s Disease* (1998) (164)
SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians (2013) (161)
τ Is Widely Expressed in Rat Tissues (1996) (159)
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. (1996) (159)
Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells* (2001) (156)
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. (2012) (153)
Immunocytochemical and ultrastructural studies of Pick's disease (1990) (151)
Active γ-Secretase Complexes Contain Only One of Each Component* (2007) (151)
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. (1998) (148)
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein (2004) (146)
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. (1998) (144)
Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase* (2006) (144)
The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells. (1998) (143)
Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. (1996) (133)
Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein* (2003) (131)
Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels (1995) (127)
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. (2009) (127)
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining (2004) (123)
GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. (1995) (121)
Truncated Carboxyl-Terminal Fragments of β-Amyloid Precursor Protein Are Processed to Amyloid β-Proteins 40 and 42† (2004) (120)
Ubiquitin is a component of paired helical filaments in Alzheimerʼs disease (1987) (119)
Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques (1998) (112)
Association of transferrin C2 allele with late-onset Alzheimer’s disease (1997) (110)
Deamidation and Isoaspartate Formation in Smeared Tau in Paired Helical Filaments (1999) (108)
Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease (1990) (108)
Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats. (1988) (108)
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex (1997) (106)
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. (1996) (103)
Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain (1998) (101)
Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain (2000) (100)
Tau is widely expressed in rat tissues. (1996) (100)
Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments (1993) (99)
Progressive neurodegeneration in C. elegans model of tauopathy (2005) (98)
Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination (1994) (97)
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. (2013) (96)
Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau. (1993) (95)
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. (2000) (92)
Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system. (1993) (91)
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging (1999) (91)
Alzheimer's disease: β‐Amyloid protein and tau (2002) (86)
Fetal-type phosphorylation of the tau in paired helical filaments. (1992) (86)
Central nervous system‐specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction (2011) (85)
SP-40,40 is a constituent of Alzheimer's amyloid (1992) (84)
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups (2015) (81)
Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). (1999) (80)
Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus. (1994) (80)
Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry (2017) (79)
Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis. (1989) (76)
Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. (2006) (76)
GM1 Ganglioside-Bound Amyloid β-Protein in Alzheimer’s Disease Brain (1998) (75)
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. (1988) (75)
Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis (1990) (74)
Gamma-secretase activity is present in rafts but is not cholesterol-dependent. (2003) (72)
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia. (1991) (72)
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. (2006) (71)
DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins: Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase† (2006) (71)
Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation. (1999) (68)
Widespread expression of α-synuclein and τ immunoreactivity in Hallervorden–Spatz syndrome with protracted clinical course (2000) (66)
Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. (2000) (64)
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. (1997) (64)
Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics (2004) (64)
Staining of Alzheimer's Neurofibrillary Tangles with Antiserum against 200K Component of Neurofilament (1981) (64)
Alzheimer β Amyloid Deposition Enhanced by ApoE ϵ4 Gene Precedes Neurofibrillary Pathology in the Frontal Association Cortex of Nondemented Senior Subjects (2001) (63)
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population. (2014) (61)
γ-Secretase Associated with Lipid Rafts (2013) (60)
Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis? (1989) (60)
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. (2007) (59)
Molecular aging of tau: disulfide‐independent aggregation and non‐enzymatic degradation in vitro and in vivo (2004) (58)
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. (2009) (56)
Glypican‐1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease (2004) (56)
Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. (2001) (55)
Localization of verotoxin receptors in nervous system (1999) (54)
Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population. (1995) (53)
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease (2012) (52)
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase (2013) (52)
Selective Deposition of Mutant Tau in the FTDP‐17 Brain Affected by the P301L Mutation (2001) (51)
Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons. (1996) (51)
The N-terminal Portion of Growth Inhibitory Factor Is Sufficient for Biological Activity (*) (1995) (49)
Senescence‐Accelerated Mouse (1996) (49)
Collapsin Response Mediator Protein-2 Inhibits Neuronal Phospholipase D2 Activity by Direct Interaction* (2002) (48)
Purification of tubulin from bovine brain and its interaction with guanine nucleotides. (1975) (47)
Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. (1994) (47)
Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. (1986) (47)
Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease (1998) (46)
Phosphoinositides Suppress γ-Secretase in Both the Detergent-soluble and -insoluble States* (2008) (46)
Accumulation of Tau in Autophagic Vacuoles in Chloroquine Myopathy (1998) (45)
Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis (2004) (45)
A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments. (1989) (45)
Amyloid β‐protein (Aβ) associated with lipid molecules: immunoreactivity distinct from that of soluble Aβ (1997) (45)
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. (2004) (44)
Tau 2: A Probe for a Ser Conformation in the Amino Terminus of τ (1992) (44)
Accumulation of neurofilaments and SOD1-immunoreactive products in a patient with familial amyotrophic lateral sclerosis with I113T SOD1 mutation. (1999) (43)
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. (2017) (43)
Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin. (1995) (43)
Aβ46 Is Processed to Aβ40 and Aβ43, but Not to Aβ42, in the Low Density Membrane Domains* (2008) (42)
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. (2003) (42)
Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease (2014) (42)
Immunostaining of Oxidized DJ-1 in Human and Mouse Brains (2014) (41)
Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. (2000) (40)
Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. (1992) (40)
Amyloid β‐protein deposition in the leptomeninges and cerebral cortex (1997) (40)
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. (2003) (39)
Accumulation of Amyloid β-Protein in the Low-Density Membrane Domain Accurately Reflects the Extent of β-Amyloid Deposition in the Brain (2001) (39)
Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia (1990) (39)
Visualization of Newly Deposited tau in Neurofibrillary Tangles and Neuropil Threads (2005) (37)
Random Mutagenesis of Presenilin-1 Identifies Novel Mutants Exclusively Generating Long Amyloid β-Peptides* (2005) (37)
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging. (1999) (37)
SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease. (2013) (37)
Curcumin improves tau-induced neuronal dysfunction of nematodes (2016) (36)
Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages (1989) (36)
Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments. (1990) (36)
Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain: Individual Variability and Correlation between APP‐751 and Four‐Repeat tau (1991) (35)
Distribution of endogenous normal tau in the mouse brain (2018) (34)
DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. (2006) (34)
The presence of an adenosine-5'-triphosphatase dependent on 6S tubulin and calcium ions in rat brain microtubules. (1979) (33)
GAB2 is not associated with late-onset Alzheimer's disease in Japanese (2009) (33)
Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. (2004) (33)
Immunocytochemical Study on Senile Plaques in Alzheimer's Disease. II (1983) (33)
Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin. (2002) (33)
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta. (2008) (32)
Senescence-accelerated mouse. Neurochemical studies on aging. (1996) (32)
Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant (1997) (32)
Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3* (2013) (31)
Blocking the cleavage at midportion between γ‐ and ε‐sites remarkably suppresses the generation of amyloid β‐protein (2005) (31)
Immunocytochemical study on senile plaques in Alzheimer's disease. II. Abnormal dendrites in senile plaques as revealed by antimicrotubule-associated proteins (MAPs) immunostaining. (1983) (30)
Microglial cells and amyloid ? protein (A?) deposition: association with A?40-containing plaques (1995) (30)
β‐Amyloid Protein Precursor and τ mRNA Levels Versus β‐Amyloid Plaque and Neurofibrillary Tangles in the Aged Human Brain (1993) (29)
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques (2004) (29)
Posttranslational modifications of tau in paired helical filaments. (1994) (29)
Amyloid β‐protein (Aβ) Accumulation in the Leptomeninges during Aging and in Alzheimer Disease (1997) (29)
Identification of β protein precursor in newborn rat brain (1989) (28)
Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex (2005) (27)
The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles (2014) (27)
Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. (2001) (26)
PHF and PHF-like fibrils –cause or consequence? (2001) (25)
Proteolytic fragments of Alzheimer's paired helical filaments. (1985) (25)
Gem GTPase and Tau (2004) (24)
Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain (1996) (24)
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain (2003) (23)
GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain. (1998) (22)
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy (2018) (21)
Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia (2004) (21)
Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau (2015) (21)
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. (2008) (20)
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. (2001) (20)
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells (2015) (20)
Amyloid β-protein (Aβ) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease (1998) (19)
Muscle fiber degeneration in distal myopathy with rimmed vacuole formation (2004) (19)
Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer??s disease (1987) (18)
530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells (1996) (17)
Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. (1993) (16)
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. (2005) (15)
Lewy Bodies: Purification from Diffuse Lewy Body Disease Brains a (1996) (15)
[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]. (1989) (15)
A possible fetal antigen ofM r70,000 in neurofibrillary tangles (1991) (15)
Amyloid beta-protein deposition in the leptomeninges and cerebral cortex. (1997) (14)
Inhibition by E-64-c of neurofilament degeneration induced by calcium ions (1981) (13)
Microglial cells and amyloid β protein (Aβ) deposition: association with Aβ40-plaques (1995) (12)
Molecular diversity at the carboxyl terminus of human and rat tau. (1994) (12)
What mediates between β-amyloid and paired helical filaments? (1989) (12)
Suspected limited efficacy of γ-secretase modulators (2013) (12)
Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization (2017) (12)
γ-Secretase activity is associated with Braak Senile Plaque stages. (2020) (12)
Neurofibrillary Tangles, Dystrophic IMeurites (Curly Fibers), and Abnormal Phosphorylation of Tau (1991) (12)
Dissociation of β‐amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β‐amyloid‐42 assembly (2011) (11)
Proliferating cell nuclear antigen (PCNA) expressed in human leptomeninges. (1996) (11)
[gamma secretase]. (2002) (11)
The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel (2010) (11)
Astrocytes Containing Amyloid (3-Protein (Af3)-Positive Granules Are Associated with A1340-Positive Diffuse Plaques in the Aged Human Brain (2007) (11)
Immunocytochemical study on senile plaques in Alzheimer's disease. I. Preparation of an antimicrotubule-associated proteins (MAPs) antiserum and its specificity.:Preparation of an Antimicrotubule-associated Proteins (MAPs) Antiserum and its Specificity (1983) (11)
Chloroquine treated rat: A possible model for alzheimer's disease (1995) (10)
Immunohistochemical detection of verotoxin receptors in nervous system. (2001) (10)
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry. (2019) (10)
Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians (2013) (9)
Amyloid beta-protein (A beta) accumulation in the leptomeninges during aging and in Alzheimer disease. (1997) (9)
Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains (2008) (9)
Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta. (1997) (9)
Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain. (1993) (9)
Effects of Specific Protease Inhibitors on Amyloid β-Protein 42 Secretion (1998) (9)
Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain (2018) (9)
Molecular pathology of Alzheimer's disease (1997) (9)
TRANSGLUTAMINASE AND CALCIUM-PROTEASE ACTIVITIES IN ALZHEIMER'S DISEASE BRAIN (1989) (8)
Effects of human apolipoprotein E isoforms on the amyloid β‐protein concentration and lipid composition in brain low‐density membrane domains (2007) (8)
The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section. (1990) (8)
Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. (1996) (8)
Association of primary hyperparathyroidism with myotonic dystrophy in two patients. (1987) (8)
Effects of specific protease inhibitors on amyloid beta-protein 42 secretion. (1998) (7)
The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats. (1991) (7)
Tau protein immunoreactivity in muscle fibers with rimmed vacuoles differs from that in regenerating muscle fibers (2004) (7)
Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia. (1990) (7)
[Alzheimer's paired helical filaments]. (1986) (7)
Dementia with Lewy Bodies: Clinical features of diffuse Lewy body disease in the elderly: analysis of 12 cases (1996) (7)
Polypeptide composition of paired helical filaments. (1989) (6)
92 DIFFERENTIAL REACTION OF ALZHEIMER NEUROFIBRILLARY TANGLES WITH ANTI-NEUROFILAMENT AND ANTI-PHF ANTIBODIES (1983) (6)
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. (1995) (6)
Fractionation of Amyloid β‐Protein (Aβ) in Alzheimer's Disease and Down's Syndrome Brains (1996) (6)
A Novel Correlation Between the Levels of β‐Amyloid Protein Precursor and τ Transcripts in the Aged Human Brain (1992) (6)
Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease. (1998) (5)
Alzheimer disease research in Japan: public funding (2006) (5)
Secretory pathway of β A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation (1992) (5)
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians (2013) (5)
[A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease]. (2005) (5)
105 ANTIBODIES TO THE FAIL TO REACT WITH NEUROFILAMENTS AND OTHER NORMAL PROTEINS (1983) (4)
TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS (PHF) IN ALZHEIMERʼS DISEASE (AD) (1986) (4)
[Recent advances in Alzheimer's disease]. (2001) (4)
The role of tau in Alzheimer's disease (2000) (3)
[Immunocytochemistry of Pick's argentophilic bodies: evidence for the involvement of high molecular weight microtubule-associated proteins (HMWP) before the appearance of tubulin]. (1985) (3)
Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation (2021) (3)
Curcumin Improves Tau-mediated Neuronal Dysfunction in Nematode (2010) (3)
Neurofibrillary tangles/paired helical filaments (1981-83). (2006) (3)
Research on Alzheimer's disease in Japan: a personal view on history and present status. (1994) (3)
Dementia with Lewy Bodies: Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease, and senile dementia of Alzheimer type (1996) (2)
Clinicopathologic Study of Dementia in Parkinson Disease (1991) (2)
[Immunocytochemical study of spheroid filament protein in amyotrophic lateral sclerosis using an antiserum to 200K peptide of neurofilament and anti-tubulin antibody]. (1983) (2)
Fractionation of amyloid beta-protein (A beta) in Alzheimer's disease and Down's syndrome brains. Presence of membrane-bound A beta. (1996) (2)
Identification of beta protein precursor in newborn rat brain. (1989) (2)
Genome-wide association study of Alzheimer's disease: A collaborative genetic study on Alzheimer's disease with Japan, Korea and the Alzheimer's Disease Genetics Consortium (2012) (2)
Amyloid (B-protein (Aß) Accumulation in the Putamen and Mammillary Body during Aging and in Alzheimer Disease (1998) (2)
Simultaneous quantification of APP and tau mRNA by RT-PCR. (1998) (1)
[Overview on Alzheimer's disease]. (2007) (1)
The phosphorylation site of the tau in paired helical filaments: An immunochemical approach (1990) (1)
Posttranslational Modifications of the Tau in PHF: Phosphorylation and Ubiquitination (1995) (1)
UBIQUITIN IN ALZHEIMER'S PAIRED HELICAL FILAMENTS: 2 (1987) (1)
CROSSLINKING OF ALZHEIMER PAIRED HELICAL FILAMENTS: ANALOGIES TO TRANSGLUTAM-INASE-CATALYZED FILAMENT CROSSLINKING IN VITRO (1982) (1)
[Alzheimer paired helical filament]. (1985) (1)
Molecular pathological studies of neurofibrillary tangle-predominant form of dementia (2000) (1)
β-Amyloid Plaques and Dementia: An Immunohistochemical Study (1990) (1)
510 Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases in brain (1996) (1)
Quantitation of Amyloid (3-Protein (Af3) in the Cortex during Aging and in Alzheimer's Disease (2007) (1)
Anomalous Stiffness Changes of Tau Protein in X-ray Single Molecule Observations (2015) (1)
Evidence That Collapsin Response Mediator Protein-2 (CRMP-2) Is Involved in the Dynamics of Microtubules (2000) (1)
759 Nonneural tau : Transient upregulation and subsequent accumulation of big and small tau in chloroquine myopathy (1996) (1)
A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain. (1992) (0)
507 Distribution of Phosphorylated Tau in Neonatal and Adult Rat Brains (1996) (0)
Gene expression profiling in postmortem brains classified by Braak neurofibrillary tangle staging (2011) (0)
Significance of Neurofibrillary Tangles in Alzheimer’s Disease—Lessons from Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (2002) (0)
[Alzheimer's disease and the proteins]. (2001) (0)
Ubiquitin: A Newly Identified Component of Paired Helical Filaments (1988) (0)
System in Alzheimer Disease Lysosomal - Proteasome System and the Autophagic - The Ubiquitin (2012) (0)
Inhibition of PARP-1 attenuates tau phosphorylation by regulation of glycogen synthase kinase-3 (2011) (0)
[Amyloid beta protein of CSF]. (2011) (0)
338 Expression of renin, kininogen and kallikrein genes in the human placenta of IUGR pregnancy. (1989) (0)
Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry (2017) (0)
Structural Fluctuations and Aggregations of Tau Proteins from X-Ray Single Molecule Observations (2014) (0)
1P082 X-ray Single Molecule Observations of Phosphorylated Tau protein's structural fluctuations(01E. Protein : Measurement & Analysis,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) (2014) (0)
Influence of diet on tumour growth. 2. Effect of a diet containing excess of vitamins on the growth of rat cancer. (1931) (0)
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells (2015) (0)
P1-157 Presence of long Aβ in the lysate: an implication for the mechanism of gamma-secretase cleavage (2004) (0)
P3-243: Gene expression profiling of postmortem brain tissues affected by Alzheimer's disease (2008) (0)
Imaging Mass Spectrometry for the Research of Alzheimer’s Disease (2016) (0)
Legends Suppl Tables (2014) (0)
Supplemental Information Semagacestat Is a Pseudo-Inhibitor of g-Secretase (0)
What mediates between beta-amyloid and paired helical filaments? (1989) (0)
517 Deamidation and isomerization of the smeared tau in paired helical filaments (1996) (0)
Longer Forms of Amyloid (cid:1) Protein: Implications for the Mechanism of Intramembrane Cleavage by (cid:2) -Secretase (2005) (0)
[A comparative study on the ability to stain senile plaques with beta protein immunostain and three kinds of silver impregnation methods]. (1988) (0)
Amyloid β-protein accumulation in the human brain during aging (2001) (0)
687 Differential patterns of amyloid β-protein deposition in cerebral cortex and leptomeninges (1996) (0)
γ-Cleavage and ε-cleavage of β-amyloid precursor protein (2003) (0)
Increased p3-Alcα, a γ-secretase Reaction Product of Alcadein, in Plasma of Sporadic Alzheimer's Disease Subjects (2010) (0)
Gene expression profiling of postmortem brain tissues with Alzheimer's disease (2010) (0)
A tale of protein kinase C and membrane lipid signaling (2001) (0)
P3-405 Equimolar production of Abeta and AICD from C99 by gamma-secretase (2006) (0)
1324 Quantification of free ubiquitin and multi-ubiquitin chains in brain tissues of autopsy cases of alzheimer's disease (1996) (0)
[Abnormal proteins in the brain in Alzheimer's disease]. (1991) (0)
P4-205: APP cleavage by gamma-secretase: To test the tripeptide hypothesis using LC-MS/MS (2008) (0)
Influence of diet on tumour growth. 1. Effect of a vitamin deficient diet on the growth of rat cancer. (1931) (0)
βCTF is an inefficient substrate for proteolysis by gamma-secretase (2010) (0)
Molecular cloning ofhumangrowthinhibitory factor cDNAanditsdown-regulation inAlzheimer's disease (1992) (0)
688 Amyloid β-protein accumulates in the leptomeninges (1996) (0)
States Both the Detergent-soluble and-insoluble-Secretase in γ Phosphoinositides Suppress Enzyme Catalysis and Regulation : (2008) (0)
Gene expression analysis in the postmortem brains classified by Braak NFT-SP staging (2012) (0)
γ-Secretase: Stepwise processing of βCTF (2009) (0)
[Biochemistry of alzheimer's disease]. (1991) (0)
[Alzheimer's disease. Biochemistry of paired helical filaments (PHF)]. (1988) (0)
793 GM1 ganglioside-bound amyloid ß-protein: A possible form of preamyloid (1996) (0)
SORL1 JAD Wen Y et al Supple 2013 (2014) (0)
Loose membrane-bound endogenous factors might modulates the intramembrane cleavages of βAPP (2009) (0)
NEUROFIBRILLARY TANGLE-PREDOMINANT FORM OF DEMENTIA – CLINICAL AND PATHOLOGICAL STUDY (1998) (0)
Dissociated nystagmus in a comatose patient (1980) (0)
Alzheimer (cid:98) Amyloid Deposition Enhanced by ApoE (cid:171) 4 Gene Precedes Neuroﬁbrillary Pathology in the Frontal Association Cortex of Nondemented Senior Subjects (2001) (0)
IMMUNOCHEMICAL EVIDENCE THAT FRAGMENTS OF PHOSPHORYLATED MAP5 (MAP1B) ARE BOUND TO NEUROFIBRILLARY TANGLES: 32 (1990) (0)
JAD140225 Miyashita TREM2 14-0225r1 140310 (2014) (0)
Paired helical filaments (PHF) and abnormally phosphorylated tau (1991) (0)
Loss of Growth Inhibitory Factor in Degenerative Disease (1995) (0)
2P084 Structural Fluctuations of Tau Proteins from X-ray Single Molecule Observations(01E. Protein: Measurement & Analysis,Poster) (2013) (0)
Authors' response to commentaries (1995) (0)
GENES ASSOCIATED WITH THE PROGRESSION OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE BRAINS (2014) (0)
Genome-wide association study of late-onset Alzheimer's disease in Japanese (2011) (0)
[The current status and perspectives in Alzheimer's disease research]. (2000) (0)
145 When and how does amyloid β-protein deposition start? (1996) (0)
Neural substrate for spatial memory in the monkey hippocampus (2001) (0)
62 a Sunday , February 8 , 2015 Intrinsically Disordered Proteins ( IDP ) and Aggregates (2015) (0)
S1-02-01 Gamma-secretase: Relationship between gamma-cleavage and epsilon-cleavage (2006) (0)
WIDESPREAD EXPRESSION OF α-SYNUCLEIN AND τ IMMUNOREACTIVITY IN HALLERVORDEN SPATZ SYNDROME WITH PROTRACTED CLINICAL COURSE (1999) (0)
Analysis of paired helical filaments deposited in the brains of Alzheimer's disease patients (1996) (0)

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What Schools Are Affiliated With Yasuo Ihara?

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