Yasushi Yamazoe

Q: What Schools Are Affiliated With Yasushi Yamazoe

Yasushi Yamazoe is affiliated with the following schools: Tohoku University, Keio University

Yasushi Yamazoe's AcademicInfluence.com Rankings

Yasushi Yamazoe

Chemistry

#4136

World Rank

#5199

Historical Rank

chemistry Degrees

Download Badge

Chemistry

Yasushi Yamazoe's Degrees

PhD Pharmaceutical Sciences University of Tokyo
Masters Pharmaceutical Sciences University of Tokyo
Bachelors Pharmaceutical Sciences University of Tokyo

Why Is Yasushi Yamazoe Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Yasushi Yamazoe's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. (2000) (248)
Inhibition selectivity of grapefruit juice components on human cytochromes P450. (2000) (227)
Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats. (1983) (219)
Pharmacogenetics of sulfotransferase. (2000) (205)
Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction. (1997) (185)
Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates. (1987) (172)
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. (1992) (162)
Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. (1987) (159)
Protective Role of Hydroxysteroid Sulfotransferase in Lithocholic Acid-induced Liver Toxicity* (2003) (148)
Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. (2007) (139)
Structural similarity and diversity of sulfotransferases. (1994) (128)
Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin. (1989) (116)
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. (2002) (113)
A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes. (1983) (111)
Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. (2005) (109)
Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. (1983) (108)
Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. (1993) (108)
Isolation and Characterization of a New Major Intestinal CYP3A Form, CYP3A62, in the Rat (2004) (105)
Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. (1993) (101)
Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein. (1996) (100)
Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. (2004) (99)
Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines. (1998) (97)
A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes (2006) (96)
Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase. (1989) (96)
Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. (1986) (92)
Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity. (2000) (92)
cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. (1990) (88)
N-hydroxylation of carcinogenic and mutagenic aromatic amines. (1983) (85)
Mechanism of activation of proximate mutagens in Ames' tester strains: the acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1,8-DNP6 catalyzes DNA-binding as the cause of mutagenicity. (1983) (83)
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (2010) (82)
Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. (1997) (81)
Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes. (1989) (81)
Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction. (2000) (76)
Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4 (2005) (75)
DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo. (1985) (75)
Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (2006) (74)
Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes. (1980) (74)
Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. (1990) (73)
Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. (2001) (72)
Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats. (1980) (71)
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements. (2008) (71)
Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction. (1997) (70)
A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. (1988) (70)
Administration of Ampicillin Elevates Hepatic Primary Bile Acid Synthesis through Suppression of Ileal Fibroblast Growth Factor 15 Expression (2009) (69)
Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems. (1998) (68)
Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidine. (1988) (66)
Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions. (2001) (66)
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system. (1990) (64)
Primary structures and properties of two related forms of aryl sulfotransferases in human liver. (1995) (63)
DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction. (1988) (63)
Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. (1988) (62)
Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice. (2011) (62)
Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. (1994) (61)
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. (1995) (60)
Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. (2002) (59)
Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. (1991) (59)
Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo (2008) (58)
Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450. (1981) (57)
Purification of human liver cytochrome P-450 catalyzing testosterone 6 beta-hydroxylation. (1987) (56)
Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P‐450 human‐2 (1990) (55)
Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction (2009) (55)
Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice. (2000) (54)
Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1 (2009) (53)
Enterobacteria Modulate Intestinal Bile Acid Transport and Homeostasis through Apical Sodium-Dependent Bile Acid Transporter (SLC10A2) Expression (2011) (53)
Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. (1986) (53)
Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes. (1980) (53)
Reactivity of benzidine diimine with DNA to form N-(deoxyguanosin-8-yl)-benzidine. (1986) (52)
Modulation of doxorubicin resistance in a doxorubicin-resistant human leukaemia cell by an immunoliposome targeting transferring receptor. (1997) (52)
DETECTION OF A NEW N-OXIDIZED METABOLITE OF FLUTAMIDE, N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]HYDROXYLAMINE, IN HUMAN LIVER MICROSOMES AND URINE OF PROSTATE CANCER PATIENTS (2006) (50)
Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes. (1986) (50)
Suppression in the expression of a male-specific cytochrome P450, P450-male: difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers. (1989) (49)
Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice (2013) (49)
Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. (1987) (49)
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes. (2007) (49)
Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450s in hypophysectomized rats. (1989) (48)
Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary. (1992) (48)
Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling. (2012) (48)
Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system. (1989) (47)
Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3. (1999) (47)
Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. (2001) (47)
Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases. (1983) (47)
Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. (1999) (46)
Unveiling a New Essential Cis Element for the Transactivation of the CYP3A4 Gene by Xenobiotics (2009) (46)
Partial purification and characterization of cytochrome P-450 responsible for the occurrence of sex difference in drug metabolism in the rat. (1981) (46)
The regulation by growth hormone of microsomal testosterone 6 beta-hydroxylase in male rat livers. (1986) (45)
Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA. (1981) (44)
Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. (2006) (44)
Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. (2003) (44)
Evidence for the involvement of multiple forms of cytochrome P-450 in the occurrence of sex-related differences of drug metabolism in the rat. (1982) (44)
Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity (2009) (44)
Metabolic activation of N-hydroxylated metabolites of carcinogenic and mutagenic arylamines and arylamides by esterification. (1994) (43)
Species difference in N-hydroxylation of a tryptophan pyrolysis product in relation to mutagenic activation. (1981) (43)
Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. (2007) (43)
Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats. (1992) (42)
Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes. (1989) (42)
Regulation of hepatic cortisol sulfotransferase in rats by pituitary growth hormone. (1989) (42)
Regulation of hepatic sulfotransferase catalyzing the activation of N-hydroxyarylamide and N-hydroxyarylamine by growth hormone. (1987) (42)
Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450 (1988) (41)
Enzymatic acetylation and sulfation of N-hydroxyarylamines in bacteria and rat livers. (1989) (41)
Molecular characterization of ST1C1-related human sulfotransferase. (1998) (41)
Sulfotransferase-mediated DNA binding of N-hydroxyarylamines(amide) in liver cytosols from human and experimental animals. (1992) (41)
Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). (1993) (41)
Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR. (1983) (40)
Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4. (2005) (39)
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase. (2006) (39)
Selective Role of Sulfotransferase 2A1 (SULT2A1) in the N-Sulfoconjugation of Quinolone Drugs in Humans (2009) (39)
The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype. (1987) (39)
Monomorphic and polymorphic isozymes of arylamine N-acetyltransferases in hamster liver: purification of the isozymes and genetic basis of N-acetylation polymorphism. (1990) (39)
Paradisin C: A new CYP3A4 inhibitor from grapefruit juice (2002) (39)
Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA (2001) (38)
Genetic polymorphism of human cytochrome p450 involved in drug metabolism. (2002) (38)
Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes. (1982) (36)
Hormonal Regulation of Cytochrome P450 in Rat Liver (1993) (36)
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. (2009) (36)
Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals. (1998) (36)
Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1. (1989) (36)
Enhancement of Binding of N-Hydroxy-TRP-P-2 to DNA by seryl-tRNA synthetase. (1981) (36)
Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene. (1984) (35)
Role of growth hormone in modulating the constitutive and phenobarbital-induced levels of two P-450(6)beta (testosterone 6 beta-hydroxylase) mRNAs in rat livers. (1989) (35)
In vitro inhibition of human small intestinal and liver microsomal astemizole O -demethylation: different contribution of CYP2J2 in the small intestine and liver (2003) (35)
Properties of cutaneous acetyltransferase catalyzing N- and O-acetylation of carcinogenic arylamines and N-hydroxyarylamine. (1988) (35)
Transcriptional Elements Directing a Liver-Specific Expression of P450/6βA (CYP3A2) Gene-Encoding Testosterone 6β-Hydroxylase (1995) (35)
DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol. (1985) (34)
Purification of hepatic N-hydroxyarylamine sulfotransferases and their regulation by growth hormone and thyroid hormone in rats. (1991) (34)
The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo. (1994) (33)
Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake. (2002) (33)
Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol. (1985) (33)
Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates. (1984) (33)
Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians (2016) (33)
High capacity of human skin for N-acetylation of arylamines. (1990) (33)
Covalent binding of N-hydroxy-Trp-P-2 to DNA by cytosolic proline-dependent system. (1982) (32)
Role of Farnesoid X Receptor in the Enhancement of Canalicular Bile Acid Output and Excretion of Unconjugated Bile Acids: A Mechanism for Protection against Cholic Acid-Induced Liver Toxicity (2005) (32)
Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor. (2012) (31)
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (1989) (31)
Structure of a Gene and cDNA of a Major Constitutive Form of Testosterone 6β-Hydroxylase (P450/6βA) Encoding CYP3A2: Comparison of the cDNA with P450PCN2 (1994) (31)
Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19 (2012) (31)
Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. (1996) (30)
Enzymatic characterization of human cytosolic sulfotransferases; identification of ST1B2 as a thyroid hormone sulfotransferase. (1999) (30)
Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. (2013) (30)
Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants (2014) (30)
Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats (2007) (29)
Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. (1990) (29)
Effect of growth hormone on rat hepatic cytochrome P-450f mRNA: a new mode of regulation (1990) (29)
Regulation of drug transporters by the farnesoid X receptor in mice. (2004) (28)
SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells. (2014) (28)
An arylamine acetyltransferase (AT‐I) from syrian golden hamster liver: Cloning, complete nucleotide sequence, and expression in mammalian cells (1991) (27)
Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. (2002) (27)
Activated Sterol Regulatory Element-Binding Protein-2 Suppresses Hepatocyte Nuclear Factor-4-Mediated Cyp3a11 Expression in Mouse Liver (2011) (27)
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity (2006) (27)
Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. (1999) (27)
Alteration of hepatic drug metabolizing activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment. (1988) (26)
Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. (2009) (25)
Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order (2011) (25)
Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene (2007) (25)
A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment. (1997) (25)
Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells. (2012) (24)
Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. (1987) (24)
Primary structure and molecular basis of polymorphic appearance of an acetyltransferase (AT-II)* in hamsters. (1994) (23)
Sulfotransferase catalyzing sulfation of heterocyclic amines. (1999) (23)
Different roles of pummelo furanocoumarin and cytochrome P450 3A5*3 polymorphism in the fate and action of felodipine. (2007) (22)
The apparent loss of cytochrome P-450 associated with metabolic activation of carbon tetrachloride. (1979) (22)
Intestinal cytochrome P450 and response to rifampicin in rabbits. (2000) (21)
Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism (2004) (21)
Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. (2002) (21)
Cytochrome P-450 human-2 (P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts. (1991) (21)
Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption (2009) (20)
Reduction of epoxy derivatives of benzo(a)pyrene by microsomal cytochrome P-450. (1980) (20)
Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice. (2012) (20)
Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. (2012) (19)
Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis. (2010) (19)
Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism (2012) (19)
Effects of ascorbic acid on the nonenzymatic binding to DNA and the mutagenicity of N-hydroxylated metabolite of a tryptophan-pyrolysis product. (1982) (19)
Genetic Polymorphism of Aldehyde Oxidase in Donryu Rats (2007) (19)
Isolation and Characterization of a New Major Intestinal CYP 3 A Form , CYP 3 A 62 , in the Rat (2004) (19)
Formation of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐ and 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐sulfamates by cDNA‐expressed Mammalian Phenol Sulfotransferases (1995) (19)
Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region (2015) (18)
Expression and functional characterization of a rat sulfotransferase (ST1A1) cDNA for sulfations of phenolic substrates in COS-1 cells. (1993) (18)
Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8) (1998) (18)
Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids. (2013) (18)
Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase. (2012) (18)
Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. (1995) (18)
Hepatic microsomal tolbutamide hydroxylation in Japanese: in vitro evidence for rapid and slow metabolizers. (1993) (18)
Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. (2004) (17)
Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes. (1980) (17)
Development of two-dimensional template system for the prediction of CYP2B6-mediated reaction sites. (2011) (17)
Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction. (2006) (17)
Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions. (2011) (17)
Distinct regulation of two hydroxysteroid sulfotransferases, ST2A1 and ST2A2, by growth hormone: a unique type of growth hormone regulation in rats. (1997) (17)
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. (2009) (16)
Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: Comparison among well-stirred, parallel-tube, distributed and dispersion models (2005) (16)
A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human livers. (1991) (16)
Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs. (1994) (16)
2-Methoxy-4-nitroaniline and its isomers induce cytochrome P4501A (CYP1A) enzymes with different selectivities in the rat liver. (1998) (16)
A high spin form of cytochrome P-448 highly purified from PCB-treated rats--II. Characteristic requirement of cytochrome b5 for maximum activity. (1983) (15)
A sensitive method for determination of biphenyl hydroxylase activities using high-performance liquid chromatography. (1981) (15)
Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum (1999) (15)
Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction. (1996) (15)
Bacterial expression and functional characterization of a rat thyroid hormone sulfotransferase, ST1B1. (1999) (15)
Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR). (2013) (15)
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals. (2016) (15)
A gene structure of testosterone 6β-hydroxylase (P450IIIA) (1991) (15)
Metabolic activation of Trp-P-2, a tryptophan-pyrolysis mutagen, by isolated rat hepatocytes. (1983) (15)
Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. (1995) (14)
Glutathione transferase-mediated and non-enzymatic activation and detoxication of the N-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen. (1984) (14)
Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation. (2003) (14)
Stereoselective oxidation and plasma protein binding of nilvadipine, a new dihydropyridine calcium antagonist, in man. (1988) (14)
Involvement of ST1B Subfamily of Cytosolic Sulfotransferase in Kynurenine Metabolism to Form Natriuretic Xanthurenic Acid Sulfate (2008) (14)
Metabolic activation of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido[4,3-b]indole(TRP-P-2) by isolated rat liver nuclei. (1981) (13)
Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid. (2010) (13)
Arylamine activating sulfotransferase in liver. (1997) (13)
Metabolic activation of trp-P-2, a mutagenic amine from tryptophan-pyrolysate, by liver microsomes from 3-methylcholanthrene-responsive and non-responsive mice. (1980) (13)
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. (1984) (13)
Structural elucidation of a mutagenic metabolite of 3-amino-1-methyl-5H-pyrido[4,3-b]indole. (1981) (13)
A hydroxysteroid sulfotransferase, st2b2, is a skin cholesterol sulfotransferase in mice. (2002) (12)
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions part 3: Difference in substrate specificity of human and rodent CYP1A2 and the refinement of predicting system. (2019) (12)
Carcinogen-DNA adduct formation as a predictor of metabolic activation pathways and reactive intermediates in benzidine carcinogenesis. (1986) (12)
Interactions between the active metabolite of tryptophan pyrolysate mutagen, N-hydroxy-Trp-P-2, and lipids: the role of lipid peroxides in the conversion of N-hydroxy-Trp-P-2 to non-reactive forms. (1983) (12)
Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes. (1995) (12)
Biogenetically Patterned Transformation of Eudesmanolide to Eremophilanolide. I. Angular Methyl Migration of 5α, 6α-Epoxy-dihydroalantolactone (1974) (12)
Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice (2012) (11)
A new Salmonella tester strain expressing a hamster acetyltransferase shows high sensitivity for arylamines. (1993) (11)
Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition. (2019) (11)
Thebaine metabolites in the urine of rhesus monkeys. (1981) (11)
Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. (2017) (10)
cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats. (1990) (10)
Dexamethasone and nitric oxide synthase gene expression in brain. (1997) (10)
Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system. (2019) (10)
Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol. (1986) (10)
Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7,12-dimethylbenz[a]anthracene-induced developmental toxicity. (2002) (10)
Alteration of hepatic sulfation by endotoxin. (1999) (10)
Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds. (1994) (10)
Isolation and characterization of human liver cytochrome b5 cDNA. (1989) (10)
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output. (2007) (10)
Activation and detoxication of carcinogenic arylamines by sulfation. (1995) (9)
Polymorphism in stereoselective hydroxylations of mephenytoin and hexobarbital by Japanese liver samples in relation to cytochrome P-450 human-2 (IIC9). (1992) (9)
Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation. (2002) (9)
Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiation (2008) (9)
Antibacterial drug treatment increases intestinal bile acid absorption via elevated levels of ileal apical sodium-dependent bile acid transporter but not organic solute transporter α protein. (2015) (9)
A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity. (2012) (8)
Purification and characterization of two amine N-sulfotransferases, AST-RB1 (ST3A1) and AST-RB2 (ST2A8), from liver cytosols of male rabbits. (1999) (8)
Antiepileptic Drug–Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator–Activated Receptor α and Peroxisome Proliferator–Activated Receptor γ Coactivator 1α–Dependent Gene Expression to Increase Blood Triglyceride Levels (2020) (8)
Fast-atom bombardment and electron-impact mass spectrometry of N-hydroxyarylamines, active intermediates of mutagenic aromatic amines. (1985) (8)
Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase. (2011) (8)
A category approach to predicting the repeated-dose hepatotoxicity of allyl esters. (2013) (8)
Differential production of interleukin-6 and its close relation to liver metastasis in clones from murine P815 mastocytoma. (1996) (8)
Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation (2016) (8)
Modulation of ethanol-mediated CYP2E1 induction by clofibrate and L-carnitine in rat liver. (1993) (8)
Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP 3 A Induction in Vitro and in Vivo (2008) (8)
Molecular cloning, expression, and enzymatic characterization of rabbit hydroxysteroid sulfotransferase AST-RB2. (1998) (7)
Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study. (2020) (7)
Molecular mechanisms of polymorphism in acetylating enzymes for arylamines and N-hydroxyarylamines in hamster liver. (1995) (7)
Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. (2019) (7)
TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes. (2010) (7)
Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system (2020) (7)
Paradisin C: A New CYP3A4 Inhibitor from Grapefruit Juice. (2002) (7)
Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes. (1989) (7)
Species Differences in Cytosolic Sulfotransferases (2005) (7)
UDP‐Glucuronosyltransferase (UGT)‐mediated attenuations of cytochrome P450 3A4 activity: UGT isoform‐dependent mechanism of suppression (2020) (7)
Effects of Gamma‐Interferon and FK506 on Resting B Cell Proliferation of New Zealand Black/White F1 Mice (1992) (7)
Soft-hydrothermal processing of red cedar bedding reduces its induction of cytochrome P450 in mouse liver (2009) (6)
Isolation and Expression of a cDNA Encoding a Male-specific Rat Sulfotransferase That Catalyzes Activation (1993) (6)
Enhancement by cysteinyl thiols of acetyltransferase-mediated, but not of sulfotransferase-mediated, binding of a pyrolysate-derived N-hydroxyarylamine, 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, to DNA. (1990) (6)
Characterization of human P450IIC isozymes by using yeast expression system. (1991) (6)
N-sulphoconjugation of amines by human cytosolic hydroxysteroid sulphotransferase. (1999) (6)
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template. (2020) (6)
New parameter that supports speculation on the possible mechanism of hypothyroidism induced by chemical substances in repeated-dose toxicity studies. (2013) (6)
cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31. (1998) (6)
Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia. (2011) (6)
Decrease in the activity of hepatic microsomal drug-metabolizing enzymes in tumor-bearing nude mice. (1982) (6)
Conversion of dihydroalantolactone to tetrahydroligularenolide a biogenetic-type transformation of eudesmanolide to eremophilanolide (1974) (5)
Prediction of differences in in vivo oral clearance of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100) between extensive and poor metabolizers from in vitro metabolic data in human liver microsomes lacking CYP2D6 activity and recombinant CYPs (2004) (5)
Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose (2000) (5)
Inhibition of CYP3A4 by 6′,7′‐dihydroxybergamottin in human CYP3A4 over‐expressed hepG2 cells (2012) (5)
Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study. (2020) (5)
Sulfotransferase- and acetyltransferase-mediated activation of carcinogenic N-hydroxyarylamines in mammals and bacteria, and their modulation by thiols. (1993) (5)
Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether. (2014) (5)
Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. (1994) (5)
Decrease in the Metabolic Activating Capacities of Arylamines in Livers Bearing Hyperplastic Nodules: Association with the Selective Changes in Hepatic P‐450 Isozymes (1990) (5)
Conversion of dihydroalantolactone to eremophilane-type derivatives: A biogenetic-type transformation (1972) (5)
2.P.90 Inhibition of hepatic cytochrome P450 isoform, CYP3A, by 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (1997) (5)
STUDIES ON SEX DIFFERENCES IN THE O-DEALKYLATION ACTIVITIES OF 7-HYDROXYCOUMARIN O-ALKYL DERIVATIVES IN LIVER MICROSOMES OF RATS (1980) (5)
Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin. (1992) (4)
Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions. (2021) (4)
Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes. (2012) (4)
Possible Role of Phosphatidylcholine and Sphingomyelin on Fumonisin B1-mediated Toxicity. (2017) (4)
Enhancement by alloxan-induced diabetes of the rate of metabolic activation of three pyrolysate carcinogens via increase in the P-448-H content in rat liver. (1988) (4)
Chapter 4 Sex-dependent Regulation of Cytochrome P-450 Expression (1990) (4)
Assessment of Nongenotoxic Mechanisms in Carcinogenicity Test of Chemicals; Quinone, Quinone Imine, and Quinone Methide as Examples (2016) (4)
Purification and properties of cytochrome P-450 and NADPH-cytochrome c (P-450) reductase from human liver microsomes. (1979) (4)
Protein-Protein Interactions between Rat Hepatic Cytochromes P 450 ( P 450 s ) and UDP-Glucuronosyltransferases ( UGTs ) : Evidence for the Functionally Active UGT in P 450-UGT Complex (2007) (4)
CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES (1992) (4)
Deciphering Key Interactions of Ligands with CYP3A4-Template* system (2021) (4)
Differences in cytochrome P450 forms involved in the metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a novel sigma ligand, in human liver and intestine. (2003) (4)
Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction. (1996) (4)
Pharmacokinetics of a Sustained-Release Dosage Form of Isosorbide Dinitrate (Frandol®) (1979) (3)
Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance–Associated Protein 3 Activation through a Novel Transcriptional Element (2016) (3)
Nefiracetam hydroxylation by rat liver microsomes and expressed human cytochrome P450s. (1996) (3)
Embryo- and Testicular-toxicities of Methoxyacetate and the Related: a Review on Possible Roles of One-carbon Transfer and Histone Modification (2015) (3)
Selective role of SULT2A1 in the N-sulfoconjugation of quinolone drugs in human (2009) (3)
Development of an in vitro system detecting pro-embryotoxin. (2002) (3)
Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model. (2006) (3)
Regulations of male-dominant P-450Md mRNA in rat liver by hormonal factors and xenobiotics. (1991) (3)
Metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenyl-ethoxy)-phenyl]-ethyl-amine-monohydrochloride (NE-100), a novel sigma ligand: contribution of cytochrome P450 forms involved in the formation of individual metabolites in human liver and small intestine. (2003) (3)
[Genetic polymorphism in human drug metabolism]. (1993) (2)
A gene structure of testosterone 6 beta-hydroxylase (P450IIIA). (1991) (2)
Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens. (1990) (2)
Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches (2022) (2)
Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression (2010) (2)
Construction of a fused grid-based template system of CYP2C9 and its application. (2022) (2)
High spin cytochrome P-448 with high activity for mutagenic activation of aromatic amines. (1983) (2)
HISTORY OF DRUG METABOLISM RESEARCH IN JAPAN* (2000) (2)
Acetyltransferase and sulfotransferase which activate mutagens and carcinogens through O-esterification mechanisms. (1990) (2)
Hazard evaluation support system (HESS): Category approach to screen chemicals which are metabolized to methoxy- or ethoxyacetic acid responsible for testicular toxicity (2014) (1)
DiŠerences in Transactivation between Rat CYP 3 A 1 and Human CYP 3 A 4 Genes by Human Pregnane X Receptor (2004) (1)
STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT (1982) (1)
Application of CYP1A2-Template System to Understand Metabolic Processes in the Safety Assessment (2022) (1)
Development of a case study on the read-across assessment of hepatotoxicity of allyl esters for OECD IATA case study project in 2015 (2016) (1)
Interferon-γ modulate Ia antigen expression on thymic reticuloepithelial cells in New Zealand mice (1988) (1)
A tribute to Frank Gonzalez (2001) (1)
Sex related difference in cytochrome p 450 (1987) (1)
A Summary Report of FSCJ Workshop “Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments” (2019) (1)
Hepatic level of mRNA in relation to polymorphism and strain difference in expression of cytochrome P-450g. (1989) (1)
Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system: Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions (2018) (1)
[Enzymes involved in metabolic activation of carcinogenic chemicals and their hormonal regulation]. (1992) (1)
Metabolism of mutagenic amino-gamma-carbolines in tryptophan pyrolysates. (1981) (1)
[Current availability of genetic information of drug metabolizing enzymes, particularly on cytochrome P450(CYP)]. (2001) (1)
Primary structure and regulation of hepatic sulfotransferases (1992) (1)
N-Nitrosodialkylamine dealkylation in reconstituted systems containing cytochrome P-450 purified from phenobarbitaland β-naphthoflavone-treated rats (2006) (1)
Construction of a fused grid-based CYP2C19-Template system and the application. (2022) (1)
Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption (2008) (1)
MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE (1981) (1)
Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro (2008) (1)
Antibacterial drug treatment causes enhanced levels of hepatic bile acid through alteration of ileal bile acid transporter expression (2012) (0)
Species Difference in M-Hydroxylation of a Tryptophan Pyrolysis Product in Relation to Mutagenic Activation 1 (2006) (0)
Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomest (2006) (0)
Decreases in the metabolic activating capacities of arylamines in preneoplastic state: association with selective changes in hepatic P-450 isozymes (1991) (0)
MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA (1983) (0)
Cytokine and toxicity of drugs (1996) (0)
MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY (1986) (0)
CHEMICAL-INDUCED DAMAGE OF BIOLOGICAL MACROMOLECULE AND THE MODULATION (particularly on the activation pathway of primary arylamine) ( Biochemical background for mechanisms of toxicity) (1985) (0)
FUNCTIONAL CHARACTERIZATON, TISSUE DISTRIBUTION AND IMMUNOLOCALIZATION OF RAT H/ORGANIC CATION ANTIPORTER MATE1 (2006) (0)
TRANSCRIPTIONAL REGULATION OF CYP3A SUBFAMILY (1999) (0)
Cytochrome P450 3A4 Enhances UDP-Glucuronosyltransferase 1A9-catalyzed Glucuronidation of SN-38, an Active Metabolite of Irinotecan (2009) (0)
Influence of grapefruit juice intake on carcinogen-induced DNA damages in target organ(Symposium : The 15th JEMS Annual Symposium"Strategy for Cancer Prevention by Foods : The Mechanisms of Antimutagenic and Anticarcinogenic Activities of Edible Plants") (2004) (0)
Involvement of nuclear receptors peroxisome proliferator -activated receptor alpha (PPAR alpha) and pregnane X receptor (PXR) in expressional regulation of organic cation/carnitine transporter OCTN2 (SLC22A5) (2006) (0)
[Antigenic specificity for DNA from lymphocytes in SLE patients]. (1987) (0)
CYTOSOLIC SULFOTRANSFERASE-MEDIATED FORMATION OF NATRIURETIC SUBSTANCE, XANTHURENIC ACID SULFATE (2008) (0)
Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting) (2003) (0)
Inhibition of skin tumor initiation and complete skin carcinogenesis by TMK688 and its possible mechanism of action (1995) (0)
Polymorphism in stereoselective hydroxylation of hexobarbital isomers in relation to P-450 human-2 (mephenytoin hydroxylase) (1990) (0)
DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect) (1978) (0)
PHARMACOKINETIC DRUG INTERACTION WITH GRAPEFRUIT JUICE (1997) (0)
Toxicity Evaluation System for Chemical Compounds Based on Bayesian Net (2008) (0)
Interethnic Differences in Drug Metabolism and Pharmacogenetics (1995) (0)
Studies on sex-related difference of cytochrome P-450 in rat liver microsomes (IV). Radial immunodiffusion assay and regulation by sex hormones of forms of cytochrome P-450 present specifically in males and females, respectively (1983) (0)
Rat liver sulfotransferase activating carcinogenic hydroxymethyl-arenes : its properties and sequence analysis of cDNA (1990) (0)
Introduction of Syrian hamster acetyltransferase gene into Salmonella typhimurium (1992) (0)
Metabolic activation and mechanism of drug toxicity: VIII. Metabolic activation of Trp-P-2, a mutagenic aromatic amine from tryptophan-pyrolysates. (1980) (0)
AN IDEA FOR FURTHER PROGRESS OF THE STUDY OF DRUG METABOLISM (2000) (0)
326 A USEFUL MEASURE OF HEPATIC DRUG-OXIDIZING CAPACITY : CAFFEINE AND TRIMETHADIONE ELIMINATION AS THE INDICATORS (1992) (0)
SULT2A1 MEDIATES N-SULFOCONJUGATION OF QUINOLONE DRUGS IN HUMANS (2009) (0)
Thyroid hormone-mediated regulation of hepatic cytochrome P-450 (1990) (0)
Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of (2016) (0)
cytochrome P450 and P-glycoprotein Mechanisms of retinoid resistance in leukemic cells: possible role of (2011) (0)
From Editor-in-chief. (2019) (0)
TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448 (1984) (0)
Expression of human P450 in exogenous system and the application to drug metabolism (1994) (0)
ACTIVATED STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 (SREBP-2) SUPPRESSES HAPATOCYTE NUCLEAR FACTOR-4-MEDIATED CYP3A11 GENE EXPRESSION IN MOUSE LIVER (2010) (0)
INDUCTION OF CYP1A2 WITH AROMATIC AMINES (1995) (0)
Development of the initial risk assessment framework of food contact materials by using the TTC concept and the usage contact factors (2007) (0)
The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology) (1984) (0)
335 – THE REDUCTION OF POLYCYCLIC AROMATIC HYDROCARBON EPOXIDES BY CYTOCHROME P-448 (1978) (0)
FATTY ACID DEPENDENT-ENZYME STIMULATED ACTIVATION OF CARCINOGENIC ARYLAMINES TO THE DEOXYRIBONUCLEIC ACID BINDING PRODUCTS (1986) (0)
CHRACTERIZATION OF PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1: ITS INFLUENCE ON CYP3A4 ACTIVITY (2010) (0)
346 – PROPERTIES OF CYTOCHROME P-450 PARTIALLY PURIFIED FROM HUMAN LIVER MICROSOMES (1978) (0)
P23 - Effect of dexamethasone treatment on cytochrome P450 3A-UDP-glucuronosyltransferase 1A interactions in rat liver (2020) (0)
FOR THE SUBSTANTIAL INTEGRATION OF IN VITRO DATA OF DRUG-DRUG INTERACTION (2008) (0)
Draft Guidance on Clinical Pharmacology Studies and on Drug Interaction Studies (2001) (0)
Molecular Mechanism of Human CYP3A4 Induction: In Vivo Analysis of CYP3A4 Induction by Use of Adenovirous Expresstion Vector (2000) (0)
Sucrose-mediated Modulation of Acetaminophen Hepatotoxicity (1998) (0)
Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
Oral Presentations – Skin Pharmacology Society, 7th Annual Meeting, October 30–31, 1990, Japan (1990) (0)
Our Recent Activities on Communication with Overseas (2008) (0)
Necessity of combined analyses tool for the understanding of chemical-induced toxicity; Lithocholate as and example (2007) (0)
A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION (1981) (0)
CONVERSION OF DIHYDROALANTOLACTONE TO TETRAHYDROLIGULARENOLIDE, A BIOGENETIC-TYPE TRANSFORMATION OF EUDESMANOLIDE TO EREMOPHILANOLIDE (1974) (0)
Dexamethasone andNitric OxideSynthase GeneExpression inBrain (1997) (0)
Effects of dicarboxylic acids on fatty acid-metabolizing enzymes in cultured rat hepatocytes. (1995) (0)
Transcriptional activation of human CYP1A1 and CYP1A2 genes by LXRα (2012) (0)
Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy. (2002) (0)
ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE (1987) (0)
Drug interaction. From molecular mechanism to its prevention. Molecular mechanism of drug interaction. (1996) (0)
A HERBICIDE PYRIBUTICARB IS MORE POTENT INDUCER OF CYP3A4 EXPRESSION INTERACTING WITH PREGNANE X RECEPTOR THAN RIFAMPICIN (2006) (0)
Enzymic Aspects on the Metabolic Activation of Aromatic and Heterocyclic Amine Mutagens in Mammalian and Bacterial Cells (1990) (0)
Endogenous factors that selectively modify drug metabolism (1990) (0)
[Problems of species specificity in toxicity evaluation. 5. Species specificity in pharmacokinetics]. (1989) (0)
Metabolic nuclear receptor and chemical-induced liver toxicity(Proceedings of the 32nd Annual Meeting) (2005) (0)
Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1) cDNA for Sulfations of Phenolic Substrates in COS-1 Cells•õ (2006) (0)
Metabolic activation of chemicals in various organs as key events for tissue specific toxicities(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS) (2002) (0)
Sulfotransferase gene super family and substrate specificity (1998) (0)
REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS (1989) (0)
MULTIPLICITY AND EXPRESSIN OF RAT CYP3A (1994) (0)
Coordinate roles of pregnane X receptor and constitutive androstane receptor in the ineffectiveness of voriconazole in mice (2012) (0)
Molecular characterization of mammalian Aryl(phenol) sulfotransferases (1993) (0)
Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
Mechanism of the changes in hepatic drug metabolizing enzymes in diabetic states (1990) (0)
PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS (1980) (0)
Evaluation of cell-based reporter assay systems for the assessment of the species-selective ligands of constitutive androstane receptor (2012) (0)
Polymorphism of Acetyltransferase in Hamster Liver: Isolation and Expression of cDNA and Genomic DNA in Cells of Different Species (1993) (0)
Posters – Skin Pharmacology Society, 7th Annual Meeting, October 30–31, 1990, Japan (1990) (0)
BIOGENETICALLY PATTERNED TRANSFORMATION OF EUDESMALONIDE TO EREMOPHILANOLIDE PART 1, ANGULAR METHYL MIGRATION OF 5ALPHA,6ALPHA-EPOXY-DIHYDROALANTOLACTONE (1975) (0)
Authors' response to Letter to the Editor by Jeff Kelsey et al. "Response to 'Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether.'" 2015. (2015) (0)
Cloning and expression of hamster arylamine acetyltransferase cDNA (1991) (0)
Molecular Mechanisms of CYP3A Gene Transactivations by Chemicals and their Species Differences (2000) (0)
B24 DRUG-INDUCED LOSS OF CONSTITUTIVE CYTOCHROME P-450 IN RAT LIVERS AND THE MECHANISM (1988) (0)
From the Editors: progress and the way forward (2002) (0)
STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect) (1979) (0)
STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM (1991) (0)
APPLICATION OF ADENOVIRUS-CYP EXPRESSION SYSTEM FOR THE STUDY OF INDIVIDUAL VARIATIONS OF DRUG METABOLISM IN HEP G2 CELLS (2004) (0)
S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT (1989) (0)
PATHWAYS AND REACTIVE INTERMEDIATES IN BENZIDINE CARCINOGENESIS (1986) (0)
Drug Conjugation: Diversity and Biological Significance (1995) (0)
CHARACTERISTICS OF SREBP-2-MEDIATED DOWN REGULATION OF CYP3A11 GENE EXPRESSION (2009) (0)
Molecular Mechanism of Human CYP3A4 Induction (2001) (0)
Inhibitory effects of plant coumarins on microsomal CYP 3A activity (1997) (0)
Prediction of Human Drug Metabolism: Regio- and Stereospecificity and P450 Substrate Contact Environment. (1997) (0)
Administration of ampicillin increases ileal Asbt protein amounts resulting in reduction of fecal bile acid excretion in mice (2010) (0)
[Carcinogens and their mechanism of action]. (1986) (0)
Nuclear receptornuclear receptor CAR down-regulates hepatic PPARα-mediated expression of HMGCS2, a key enzyme of ketogenesis (2012) (0)
Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Yasushi Yamazoe?

Yasushi Yamazoe is affiliated with the following schools: