Yasushi Yamazoe
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Chemistry
Yasushi Yamazoe's Degrees
- PhD Pharmaceutical Sciences University of Tokyo
- Masters Pharmaceutical Sciences University of Tokyo
- Bachelors Pharmaceutical Sciences University of Tokyo
Why Is Yasushi Yamazoe Influential?
(Suggest an Edit or Addition)Yasushi Yamazoe's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. (2000) (248)
- Inhibition selectivity of grapefruit juice components on human cytochromes P450. (2000) (227)
- Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats. (1983) (219)
- Pharmacogenetics of sulfotransferase. (2000) (205)
- Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction. (1997) (185)
- Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates. (1987) (172)
- Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. (1992) (162)
- Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. (1987) (159)
- Protective Role of Hydroxysteroid Sulfotransferase in Lithocholic Acid-induced Liver Toxicity* (2003) (148)
- Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. (2007) (139)
- Structural similarity and diversity of sulfotransferases. (1994) (128)
- Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin. (1989) (116)
- Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. (2002) (113)
- A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes. (1983) (111)
- Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. (2005) (109)
- Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. (1983) (108)
- Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. (1993) (108)
- Isolation and Characterization of a New Major Intestinal CYP3A Form, CYP3A62, in the Rat (2004) (105)
- Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. (1993) (101)
- Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein. (1996) (100)
- Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. (2004) (99)
- Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines. (1998) (97)
- A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes (2006) (96)
- Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase. (1989) (96)
- Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. (1986) (92)
- Inhibitory effect of natural furanocoumarins on human microsomal cytochrome P450 3A activity. (2000) (92)
- cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. (1990) (88)
- N-hydroxylation of carcinogenic and mutagenic aromatic amines. (1983) (85)
- Mechanism of activation of proximate mutagens in Ames' tester strains: the acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1,8-DNP6 catalyzes DNA-binding as the cause of mutagenicity. (1983) (83)
- Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (2010) (82)
- Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. (1997) (81)
- Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes. (1989) (81)
- Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction. (2000) (76)
- Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4 (2005) (75)
- DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo. (1985) (75)
- Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (2006) (74)
- Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes. (1980) (74)
- Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. (1990) (73)
- Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. (2001) (72)
- Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats. (1980) (71)
- Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements. (2008) (71)
- Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction. (1997) (70)
- A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. (1988) (70)
- Administration of Ampicillin Elevates Hepatic Primary Bile Acid Synthesis through Suppression of Ileal Fibroblast Growth Factor 15 Expression (2009) (69)
- Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems. (1998) (68)
- Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidine. (1988) (66)
- Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions. (2001) (66)
- Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system. (1990) (64)
- Primary structures and properties of two related forms of aryl sulfotransferases in human liver. (1995) (63)
- DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction. (1988) (63)
- Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. (1988) (62)
- Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice. (2011) (62)
- Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. (1994) (61)
- A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. (1995) (60)
- Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. (2002) (59)
- Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. (1991) (59)
- Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo (2008) (58)
- Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450. (1981) (57)
- Purification of human liver cytochrome P-450 catalyzing testosterone 6 beta-hydroxylation. (1987) (56)
- Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P‐450 human‐2 (1990) (55)
- Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction (2009) (55)
- Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice. (2000) (54)
- Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1 (2009) (53)
- Enterobacteria Modulate Intestinal Bile Acid Transport and Homeostasis through Apical Sodium-Dependent Bile Acid Transporter (SLC10A2) Expression (2011) (53)
- Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. (1986) (53)
- Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes. (1980) (53)
- Reactivity of benzidine diimine with DNA to form N-(deoxyguanosin-8-yl)-benzidine. (1986) (52)
- Modulation of doxorubicin resistance in a doxorubicin-resistant human leukaemia cell by an immunoliposome targeting transferring receptor. (1997) (52)
- DETECTION OF A NEW N-OXIDIZED METABOLITE OF FLUTAMIDE, N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]HYDROXYLAMINE, IN HUMAN LIVER MICROSOMES AND URINE OF PROSTATE CANCER PATIENTS (2006) (50)
- Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes. (1986) (50)
- Suppression in the expression of a male-specific cytochrome P450, P450-male: difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers. (1989) (49)
- Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice (2013) (49)
- Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. (1987) (49)
- Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes. (2007) (49)
- Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450s in hypophysectomized rats. (1989) (48)
- Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary. (1992) (48)
- Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling. (2012) (48)
- Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system. (1989) (47)
- Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3. (1999) (47)
- Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. (2001) (47)
- Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases. (1983) (47)
- Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. (1999) (46)
- Unveiling a New Essential Cis Element for the Transactivation of the CYP3A4 Gene by Xenobiotics (2009) (46)
- Partial purification and characterization of cytochrome P-450 responsible for the occurrence of sex difference in drug metabolism in the rat. (1981) (46)
- The regulation by growth hormone of microsomal testosterone 6 beta-hydroxylase in male rat livers. (1986) (45)
- Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA. (1981) (44)
- Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. (2006) (44)
- Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. (2003) (44)
- Evidence for the involvement of multiple forms of cytochrome P-450 in the occurrence of sex-related differences of drug metabolism in the rat. (1982) (44)
- Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity (2009) (44)
- Metabolic activation of N-hydroxylated metabolites of carcinogenic and mutagenic arylamines and arylamides by esterification. (1994) (43)
- Species difference in N-hydroxylation of a tryptophan pyrolysis product in relation to mutagenic activation. (1981) (43)
- Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. (2007) (43)
- Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats. (1992) (42)
- Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes. (1989) (42)
- Regulation of hepatic cortisol sulfotransferase in rats by pituitary growth hormone. (1989) (42)
- Regulation of hepatic sulfotransferase catalyzing the activation of N-hydroxyarylamide and N-hydroxyarylamine by growth hormone. (1987) (42)
- Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450 (1988) (41)
- Enzymatic acetylation and sulfation of N-hydroxyarylamines in bacteria and rat livers. (1989) (41)
- Molecular characterization of ST1C1-related human sulfotransferase. (1998) (41)
- Sulfotransferase-mediated DNA binding of N-hydroxyarylamines(amide) in liver cytosols from human and experimental animals. (1992) (41)
- Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). (1993) (41)
- Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR. (1983) (40)
- Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4. (2005) (39)
- Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase. (2006) (39)
- Selective Role of Sulfotransferase 2A1 (SULT2A1) in the N-Sulfoconjugation of Quinolone Drugs in Humans (2009) (39)
- The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype. (1987) (39)
- Monomorphic and polymorphic isozymes of arylamine N-acetyltransferases in hamster liver: purification of the isozymes and genetic basis of N-acetylation polymorphism. (1990) (39)
- Paradisin C: A new CYP3A4 inhibitor from grapefruit juice (2002) (39)
- Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA (2001) (38)
- Genetic polymorphism of human cytochrome p450 involved in drug metabolism. (2002) (38)
- Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes. (1982) (36)
- Hormonal Regulation of Cytochrome P450 in Rat Liver (1993) (36)
- Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. (2009) (36)
- Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals. (1998) (36)
- Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1. (1989) (36)
- Enhancement of Binding of N-Hydroxy-TRP-P-2 to DNA by seryl-tRNA synthetase. (1981) (36)
- Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene. (1984) (35)
- Role of growth hormone in modulating the constitutive and phenobarbital-induced levels of two P-450(6)beta (testosterone 6 beta-hydroxylase) mRNAs in rat livers. (1989) (35)
- In vitro inhibition of human small intestinal and liver microsomal astemizole O -demethylation: different contribution of CYP2J2 in the small intestine and liver (2003) (35)
- Properties of cutaneous acetyltransferase catalyzing N- and O-acetylation of carcinogenic arylamines and N-hydroxyarylamine. (1988) (35)
- Transcriptional Elements Directing a Liver-Specific Expression of P450/6βA (CYP3A2) Gene-Encoding Testosterone 6β-Hydroxylase (1995) (35)
- DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol. (1985) (34)
- Purification of hepatic N-hydroxyarylamine sulfotransferases and their regulation by growth hormone and thyroid hormone in rats. (1991) (34)
- The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo. (1994) (33)
- Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake. (2002) (33)
- Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol. (1985) (33)
- Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates. (1984) (33)
- Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians (2016) (33)
- High capacity of human skin for N-acetylation of arylamines. (1990) (33)
- Covalent binding of N-hydroxy-Trp-P-2 to DNA by cytosolic proline-dependent system. (1982) (32)
- Role of Farnesoid X Receptor in the Enhancement of Canalicular Bile Acid Output and Excretion of Unconjugated Bile Acids: A Mechanism for Protection against Cholic Acid-Induced Liver Toxicity (2005) (32)
- Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor. (2012) (31)
- cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (1989) (31)
- Structure of a Gene and cDNA of a Major Constitutive Form of Testosterone 6β-Hydroxylase (P450/6βA) Encoding CYP3A2: Comparison of the cDNA with P450PCN2 (1994) (31)
- Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19 (2012) (31)
- Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. (1996) (30)
- Enzymatic characterization of human cytosolic sulfotransferases; identification of ST1B2 as a thyroid hormone sulfotransferase. (1999) (30)
- Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. (2013) (30)
- Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants (2014) (30)
- Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats (2007) (29)
- Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. (1990) (29)
- Effect of growth hormone on rat hepatic cytochrome P-450f mRNA: a new mode of regulation (1990) (29)
- Regulation of drug transporters by the farnesoid X receptor in mice. (2004) (28)
- SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells. (2014) (28)
- An arylamine acetyltransferase (AT‐I) from syrian golden hamster liver: Cloning, complete nucleotide sequence, and expression in mammalian cells (1991) (27)
- Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. (2002) (27)
- Activated Sterol Regulatory Element-Binding Protein-2 Suppresses Hepatocyte Nuclear Factor-4-Mediated Cyp3a11 Expression in Mouse Liver (2011) (27)
- Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity (2006) (27)
- Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. (1999) (27)
- Alteration of hepatic drug metabolizing activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment. (1988) (26)
- Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. (2009) (25)
- Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order (2011) (25)
- Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene (2007) (25)
- A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment. (1997) (25)
- Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells. (2012) (24)
- Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. (1987) (24)
- Primary structure and molecular basis of polymorphic appearance of an acetyltransferase (AT-II)* in hamsters. (1994) (23)
- Sulfotransferase catalyzing sulfation of heterocyclic amines. (1999) (23)
- Different roles of pummelo furanocoumarin and cytochrome P450 3A5*3 polymorphism in the fate and action of felodipine. (2007) (22)
- The apparent loss of cytochrome P-450 associated with metabolic activation of carbon tetrachloride. (1979) (22)
- Intestinal cytochrome P450 and response to rifampicin in rabbits. (2000) (21)
- Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism (2004) (21)
- Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. (2002) (21)
- Cytochrome P-450 human-2 (P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts. (1991) (21)
- Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption (2009) (20)
- Reduction of epoxy derivatives of benzo(a)pyrene by microsomal cytochrome P-450. (1980) (20)
- Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice. (2012) (20)
- Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. (2012) (19)
- Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis. (2010) (19)
- Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism (2012) (19)
- Effects of ascorbic acid on the nonenzymatic binding to DNA and the mutagenicity of N-hydroxylated metabolite of a tryptophan-pyrolysis product. (1982) (19)
- Genetic Polymorphism of Aldehyde Oxidase in Donryu Rats (2007) (19)
- Isolation and Characterization of a New Major Intestinal CYP 3 A Form , CYP 3 A 62 , in the Rat (2004) (19)
- Formation of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐ and 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐sulfamates by cDNA‐expressed Mammalian Phenol Sulfotransferases (1995) (19)
- Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region (2015) (18)
- Expression and functional characterization of a rat sulfotransferase (ST1A1) cDNA for sulfations of phenolic substrates in COS-1 cells. (1993) (18)
- Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8) (1998) (18)
- Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids. (2013) (18)
- Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase. (2012) (18)
- Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. (1995) (18)
- Hepatic microsomal tolbutamide hydroxylation in Japanese: in vitro evidence for rapid and slow metabolizers. (1993) (18)
- Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. (2004) (17)
- Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes. (1980) (17)
- Development of two-dimensional template system for the prediction of CYP2B6-mediated reaction sites. (2011) (17)
- Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction. (2006) (17)
- Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions. (2011) (17)
- Distinct regulation of two hydroxysteroid sulfotransferases, ST2A1 and ST2A2, by growth hormone: a unique type of growth hormone regulation in rats. (1997) (17)
- Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. (2009) (16)
- Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: Comparison among well-stirred, parallel-tube, distributed and dispersion models (2005) (16)
- A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human livers. (1991) (16)
- Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs. (1994) (16)
- 2-Methoxy-4-nitroaniline and its isomers induce cytochrome P4501A (CYP1A) enzymes with different selectivities in the rat liver. (1998) (16)
- A high spin form of cytochrome P-448 highly purified from PCB-treated rats--II. Characteristic requirement of cytochrome b5 for maximum activity. (1983) (15)
- A sensitive method for determination of biphenyl hydroxylase activities using high-performance liquid chromatography. (1981) (15)
- Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum (1999) (15)
- Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction. (1996) (15)
- Bacterial expression and functional characterization of a rat thyroid hormone sulfotransferase, ST1B1. (1999) (15)
- Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR). (2013) (15)
- Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals. (2016) (15)
- A gene structure of testosterone 6β-hydroxylase (P450IIIA) (1991) (15)
- Metabolic activation of Trp-P-2, a tryptophan-pyrolysis mutagen, by isolated rat hepatocytes. (1983) (15)
- Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. (1995) (14)
- Glutathione transferase-mediated and non-enzymatic activation and detoxication of the N-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen. (1984) (14)
- Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation. (2003) (14)
- Stereoselective oxidation and plasma protein binding of nilvadipine, a new dihydropyridine calcium antagonist, in man. (1988) (14)
- Involvement of ST1B Subfamily of Cytosolic Sulfotransferase in Kynurenine Metabolism to Form Natriuretic Xanthurenic Acid Sulfate (2008) (14)
- Metabolic activation of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido[4,3-b]indole(TRP-P-2) by isolated rat liver nuclei. (1981) (13)
- Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid. (2010) (13)
- Arylamine activating sulfotransferase in liver. (1997) (13)
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- PATHWAYS AND REACTIVE INTERMEDIATES IN BENZIDINE CARCINOGENESIS (1986) (0)
- Drug Conjugation: Diversity and Biological Significance (1995) (0)
- CHARACTERISTICS OF SREBP-2-MEDIATED DOWN REGULATION OF CYP3A11 GENE EXPRESSION (2009) (0)
- Molecular Mechanism of Human CYP3A4 Induction (2001) (0)
- Inhibitory effects of plant coumarins on microsomal CYP 3A activity (1997) (0)
- Prediction of Human Drug Metabolism: Regio- and Stereospecificity and P450 Substrate Contact Environment. (1997) (0)
- Administration of ampicillin increases ileal Asbt protein amounts resulting in reduction of fecal bile acid excretion in mice (2010) (0)
- [Carcinogens and their mechanism of action]. (1986) (0)
- Nuclear receptornuclear receptor CAR down-regulates hepatic PPARα-mediated expression of HMGCS2, a key enzyme of ketogenesis (2012) (0)
- Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
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What Schools Are Affiliated With Yasushi Yamazoe?
Yasushi Yamazoe is affiliated with the following schools:
