Yasuyuki Igarashi
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(Suggest an Edit or Addition)Yasuyuki Igarashi's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature (2002) (482)
- Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. (1997) (448)
- Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia (2012) (439)
- Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. (1995) (419)
- Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. (2006) (393)
- Functional role of glycosphingolipids in cell recognition and signaling. (1995) (380)
- Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. (2005) (352)
- Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance (2007) (351)
- Ganglioside GM3 Participates in the Pathological Conditions of Insulin Resistance* (2002) (348)
- ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis (2010) (297)
- Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction (1995) (274)
- Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood* (2002) (258)
- Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. (1989) (253)
- Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice* (2014) (231)
- Ceramide biosynthesis in keratinocyte and its role in skin function. (2009) (222)
- Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. (2000) (221)
- Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. (1992) (216)
- Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. (1995) (203)
- Sphingosine 1-Phosphate Induces Platelet Activation through an Extracellular Action and Shares a Platelet Surface Receptor with Lysophosphatidic Acid* (1997) (199)
- Sphingosine 1-phosphate: synthesis and release. (2001) (198)
- A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐β peptide (2015) (197)
- Sphingosine and its methylated derivative N,N‐dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines (1996) (179)
- A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils (1994) (176)
- Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. (2007) (174)
- Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2* (2003) (170)
- Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. (2007) (169)
- N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. (1996) (165)
- LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. (2006) (164)
- TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. (2004) (164)
- Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes* (2011) (153)
- Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. (2004) (143)
- Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. (2007) (143)
- High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. (2006) (134)
- Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. (1993) (133)
- Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. (1991) (132)
- Ceramide Kinase Is a Mediator of Calcium-dependent Degranulation in Mast Cells* (2004) (128)
- GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction. (1994) (125)
- Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. (2005) (125)
- Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways. (1997) (122)
- Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. (2003) (119)
- Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat” (2012) (117)
- Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. (1995) (113)
- Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner Published, JLR Papers in Press, December 21, 2005. (2006) (108)
- Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500268-JLR200 (2005) (107)
- Lipid asymmetry of the eukaryotic plasma membrane: functions and related enzymes. (2006) (105)
- Dietary glucosylceramide improves skin barrier function in hairless mice. (2006) (105)
- A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. (1990) (101)
- Identification and Characterization of aSaccharomyces cerevisiae Gene, RSB1, Involved in Sphingoid Long-chain Base Release* (2002) (99)
- Characterization of four mammalian 3‐hydroxyacyl‐CoA dehydratases involved in very long‐chain fatty acid synthesis (2008) (95)
- Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry. (2004) (94)
- Identification of the human sphingolipid C4‐hydroxylase, hDES2, and its up‐regulation during keratinocyte differentiation (2004) (89)
- Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. (2008) (89)
- Mouse Sphingosine Kinase Isoforms SPHK1a and SPHK1b Differ in Enzymatic Traits Including Stability, Localization, Modification, and Oligomerization* (2006) (88)
- A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. (1990) (86)
- Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes. (2007) (85)
- Csg1p and Newly Identified Csh1p Function in Mannosylinositol Phosphorylceramide Synthesis by Interacting with Csg2p* (2003) (83)
- Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note. (1994) (83)
- Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm* (2003) (83)
- FVT-1 Is a Mammalian 3-Ketodihydrosphingosine Reductase with an Active Site That Faces the Cytosolic Side of the Endoplasmic Reticulum Membrane* (2004) (81)
- Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. (1997) (79)
- Exosomes as Carriers of Alzheimer's Amyloid-ß (2017) (79)
- Regulatory role of ceramide in interleukin (IL)-1 beta-induced E-selectin expression in human umbilical vein endothelial cells. Ceramide enhances IL-1 beta action, but is not sufficient for E-selectin expression. (1996) (79)
- Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. (1999) (77)
- Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. (1991) (76)
- N‐Glycans of sphingosine 1‐phosphate receptor Edg‐1 regulate ligand‐induced receptor internalization (2002) (76)
- Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles. (1998) (74)
- Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. (1997) (73)
- Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. (2005) (72)
- The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. (1995) (71)
- Gangliosides that modulate membrane protein function. (1989) (70)
- Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. (1989) (68)
- Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate (2000) (67)
- Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles. (1980) (64)
- Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease. (2014) (62)
- Membrane Topology and Essential Amino Acid Residues of Phs1, a 3-Hydroxyacyl-CoA Dehydratase Involved in Very Long-chain Fatty Acid Elongation* (2008) (62)
- Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation* (2011) (62)
- Ceramide kinase deficiency improves diet‐induced obesity and insulin resistance (2012) (61)
- Cell Type-specific Localization of Sphingosine Kinase 1a in Human Tissues (2001) (60)
- In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. (1997) (60)
- Identification of functional nuclear export sequences in human sphingosine kinase 1. (2003) (60)
- Calmodulin Is Involved in the Ca2+-dependent Activation of Ceramide Kinase as a Calcium Sensor* (2005) (59)
- Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway (2012) (56)
- Products by the sphingosine kinase/sphingosine 1‐phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis (2005) (56)
- The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry. (2008) (56)
- Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities (2012) (56)
- Sphingosine induces apoptosis in androgen‐independent human prostatic carcinoma DU‐145 cells by suppression of bcl‐XL gene expression (1997) (54)
- Sphingosine 1‐phosphate promotes cell migration through the activation of Cdc42 in Edg‐6/S1P4‐expressing cells (2003) (52)
- Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D. (2003) (51)
- Involvement of Neutral Ceramidase in Ceramide Metabolism at the Plasma Membrane and in Extracellular Milieu* (2005) (48)
- The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S] (2011) (48)
- Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. (2007) (47)
- Long-Chain Base Kinase Lcb4 Is Anchored to the Membrane through Its Palmitoylation by Akr1 (2005) (47)
- Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation (2013) (47)
- Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. (2005) (46)
- Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition (2004) (45)
- Physiological and pathological roles of exosomes in the nervous system (2016) (45)
- Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. (2004) (43)
- The immunomodulator FTY720 is phosphorylated and released from platelets. (2007) (42)
- Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1. (2005) (41)
- The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. (2007) (41)
- Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. (1998) (40)
- The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels. (2006) (39)
- Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes. (2006) (38)
- Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. (2006) (38)
- Plasmalopsychosine, a novel plasmal (fatty aldehyde) conjugate of psychosine with cyclic acetal linkage. Isolation and characterization from human brain white matter. (1992) (38)
- Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma (2010) (38)
- Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine. (1991) (37)
- Transmembrane topology of sphingoid long‐chain base‐1‐phosphate phosphatase, Lcb3p (2003) (37)
- Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils. (1992) (36)
- Endogenous substrates of sphingosine-dependent kinases (SDKs) are chaperone proteins: heat shock proteins, glucose-regulated proteins, protein disulfide isomerase, and calreticulin. (1999) (36)
- Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. (2019) (36)
- Glycosphingolipid deficiency affects functional microdomain formation in Lewis lung carcinoma cells (2000) (35)
- Regulation of the Transport and Protein Levels of the Inositol Phosphorylceramide Mannosyltransferases Csg1 and Csh1 by the Ca2+-binding Protein Csg2* (2007) (35)
- A neonatal mass-screening for congenital adrenal hyperplasia in Japan. (1984) (33)
- 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin (2012) (33)
- Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy (2010) (32)
- Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. (1994) (31)
- Qualitative and Quantitative Cellular Glycomics of Glycosphingolipids Based on Rhodococcal Endoglycosylceramidase-assisted Glycan Cleavage, Glycoblotting-assisted Sample Preparation, and Matrix-assisted Laser Desorption Ionization Tandem Time-of-flight Mass Spectrometry Analysis* (2011) (31)
- Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells. (2003) (31)
- Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III. (1994) (31)
- Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells. (1998) (31)
- Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein. (2006) (30)
- Overexpression ofBax sensitizes breast cancer MCF-7 cells to cisplatin and etoposide (2006) (29)
- Sphingosine‐1‐phosphate Inhibits Haptotactic Motility by Overproduction of Focal Adhesion Sites in B16 Melanoma Cells through EDG‐Induced Activation of Rho (2000) (29)
- Sphingosine 1-phosphate breakdown in platelets. (2004) (29)
- ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation. (2010) (28)
- Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. (2003) (28)
- Plasma renin activity in congenital virilizing adrenal hyperplasia. (1968) (28)
- Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. (1999) (27)
- Disaccharide analysis of human skin glycosaminoglycans in sun-exposed and sun-protected skin of aged people. (1996) (27)
- Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. (2016) (27)
- Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus (2016) (26)
- Influence of the pattern size of micropatterned scaffolds on cell morphology, proliferation, migration and F-actin expression. (2014) (26)
- Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice (2016) (26)
- Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response. (2017) (26)
- Phosphorylation by Pho85 Cyclin-dependent Kinase Acts as a Signal for the Down-regulation of the Yeast Sphingoid Long-chain Base Kinase Lcb4 during the Stationary Phase* (2005) (26)
- Effect of Honeycomb-Patterned Surface Topography on the Function of Mesenteric Adipocytes (2010) (25)
- Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells. (2006) (25)
- The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity (2005) (25)
- Effects of exogenous gangliosides on intracellular Ca2+ mobilization and functional responses in human platelets. (1996) (24)
- Substitution of the N-glycan function in glycosyltransferases by specific amino acids: ST3Gal-V as a model enzyme. (2006) (24)
- Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis. (2006) (24)
- Myocardial and endothelial protection by TMS in ischemia-reperfusion injury. (1995) (24)
- Suppression of Integrin Expression and Tumorigenicity by Sulfation of Lactosylceramide in 3LL Lewis Lung Carcinoma Cells* (2001) (24)
- Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors (2011) (24)
- Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. (2015) (24)
- Role of ceramide kinase in peroxisome proliferator‐activated receptor beta‐induced cell survival of mouse keratinocytes (2008) (23)
- Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids. (2009) (23)
- Transbilayer movement of ceramide in the plasma membrane of live cells. (2007) (23)
- Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease (2019) (22)
- Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells (2008) (21)
- Sphingosine‐1‐Phosphate as an Intercellular Signaling Molecule a (1998) (21)
- Inhibition of MAP kinase by sphingosine and its methylated derivative, N,N-dimethylsphingosine. (1997) (20)
- Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine (2013) (20)
- Palmitoylation of the sphingosine 1‐phosphate receptor S1P1 is involved in its signaling functions and internalization (2009) (20)
- Chemical synthesis of D-erythro-sphingosine-1-phosphate, and its inhibitory effect on cell motility (1992) (20)
- Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice (2011) (20)
- Demonstration and characterization of partial glyceride specific lipases in pig thyroid plasma membranes. (1980) (20)
- GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non‐small cell lung cancer (2007) (20)
- A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain gangliosides in rats with cerebral ischemia. (2003) (19)
- A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. (2008) (18)
- Regulation of the Sphingoid Long-chain Base Kinase Lcb4p by Ergosterol and Heme (2005) (18)
- Regulatory Role of Ceramide in Interleukin (IL)-1-induced E-selectin Expression in Human Umbilical Vein Endothelial Cells (1996) (17)
- Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis. (2012) (17)
- Quantitative GSL-glycome analysis of human whole serum based on an EGCase digestion and glycoblotting method[S] (2015) (17)
- Phytosphingosine is a novel activator of GPR120 (2018) (16)
- Physiological levels of insulin and IGF‐1 synergistically enhance the differentiation of mesenteric adipocytes. (2008) (16)
- Ceramide 1-Phosphate (2006) (16)
- Overexpression of bax enhances the radiation sensitivity in human breast cancer cells. (1997) (16)
- Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. (1996) (16)
- Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. (2019) (15)
- Sphingosine 1-Phosphate Inhibits Nitric Oxide Production Induced by Interleukin-1β in Rat Vascular Smooth Muscle Cells (2008) (15)
- Cooperative inhibitory effect of n,n,n-trimethylsphingosine and sphingosine-1-phosphate, co-incorporated in liposomes, on b16 melanoma cell metastasis - cell-membrane signaling as a target in cancer-therapy .4. (1995) (14)
- A role of lyso-phosphatidylcholine in GM3-dependent inhibition of epidermal growth factor receptor autophosphorylation in A431 plasma membranes. (1990) (14)
- Kinetics of the Ceramide Kinase Inhibitor K1, a Suppressor of Mast-Cell Activation (2007) (14)
- Sphingolipids Synthesis, Transport and Cellular Signaling (2006) (14)
- A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate. (2012) (14)
- Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors. (2009) (14)
- Lymphopenia induced by a novel selective S1P(1) antagonist structurally unrelated to S1P. (2012) (13)
- Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action (2015) (13)
- Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells. (2005) (12)
- Sphingolipids in lipid microdomains and obesity. (2013) (12)
- Substrate-specific modulation of Src-mediated phosphorylation of Ras and caseins by sphingosines and other substrate modulators. (1992) (11)
- Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography (2006) (11)
- Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. (2003) (11)
- Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. (2013) (11)
- Attenuation of cell motility observed with high doses of sphingosine 1‐phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P (2008) (11)
- Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine. (1998) (11)
- Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. (2005) (10)
- Lysosomal‐associated transmembrane protein 4B regulates ceramide‐induced exosome release (2020) (10)
- Transient increase in prostaglandin production as an acute response of thyroid isolated follicles to thyrotropin. (1981) (10)
- Cell growth arrest by sialic acid clusters in ganglioside GM3 mimetic polymers. (2007) (10)
- N,N-dimethylsphingosine phosphorylation in human platelets. (1997) (10)
- Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells (2004) (10)
- Intracellular Trafficking Pathway of Yeast Long-chain Base Kinase Lcb4, from Its Synthesis to Its Degradation* (2007) (10)
- Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants (2015) (10)
- Corrigendum to “Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1” [Biochim. Biophys. Acta 1738 (2005) 82–90] (2007) (9)
- Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60 (2007) (9)
- N,N,N‐trimethylsphingosine inhibits interleukin‐1β‐induced NF‐κB activation and consequent E‐selectin expression in human umbilical vein endothelial cells (1995) (9)
- Effects of Asterias amurensis-derived Sphingoid Bases on the de novo Ceramide Synthesis in Cultured Normal Human Epidermal Keratinocytes. (2016) (9)
- Invariant Valpha14 natural killer T cell activation by edible mushroom acidic glycosphingolipids. (2010) (9)
- Synthesis of sphingosine conjugate with controlled pore glass beads (1995) (8)
- Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression. (2010) (8)
- Blood-brain barrier permeability analysis of plant ceramides (2020) (8)
- The fungal 9-methyl-sphingadiene is a novel ligand for both PPARγ and GPR120 (2018) (8)
- Overexpression ofbax enhances the radiation sensitivity in human breast cancer cells (2005) (8)
- Sphingomyelin in microdomains of the plasma membrane regulates amino acid‐stimulated mTOR signal activation (2018) (8)
- Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph (2021) (8)
- GLYCOSPHINGOLIPIDS AND SPHINGOLIPIDS CLOSELY ASSOCIATED WITH OR CAUSING APOPTOSIS (1995) (8)
- Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase , hSPP 2 * (2002) (8)
- Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells. (2005) (8)
- The Water Retention Effects and Action for Atopic Dermatitis-like Symptoms of Ethyl Alcohol Extract (from Tamogi-take Mushroom) on Animal Model of Atopic Dermatitis (2008) (7)
- A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. (2008) (7)
- Erratum: Targeting ceramide synthase 6–dependent metastasis-prone phenotype in lung cancer cells Citation for this expression of concern (Journal of Clinical Investigation (2019) 129:8 (3464) Doi:10.1172/JCI131245) (2019) (7)
- Possible Roles of Sphingosine and N, N-Dimethylsphingosine as Modulators in Membrane Signal Transduction Systems (1990) (7)
- Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors , and antagonized by sphingosine-1-phosphate (2005) (7)
- Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation. (2010) (7)
- Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. (2019) (7)
- Disorder:Involvement of Ganglioside GM3 (2004) (7)
- Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by FSPE (2016) (6)
- Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells. (2006) (6)
- Direct Involvement of Arachidonic Acid in the Development of Ear Edema via TRPV3. (2017) (6)
- Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway. (2018) (6)
- Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats. (2017) (5)
- Membrane Sphingolipid Signaling Pathways (1997) (5)
- Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor. (2018) (5)
- Highly efficient preparation of sphingoid bases from glucosylceramides by chemoenzymatic method[S] (2016) (5)
- LASS3 is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity (2006) (5)
- Glycosphingolipids govern gene expression (2003) (5)
- Linking glycosphingolipids to Alzheimer’s amyloid-ß: extracellular vesicles and functional plant materials (2022) (5)
- Modulation of surface stiffness and cell patterning on polymer films using micropatterns. (2018) (5)
- Serum magnesium level in the salt-losing type of congenital adrenal hyperplasia. (1968) (4)
- Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism (2019) (4)
- Isolation of Sphingoid Bases from Starfish Asterias amurensis Glucosylceramides and Their Effects on Sphingolipid Production in Cultured Keratinocytes. (2019) (4)
- Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1. (2018) (4)
- Neurite Outgrowth and Morphological Changes Induced by 8-trans Unsaturation of Sphingadienine in kCer Molecular Species (2019) (3)
- Minocycline-related lupus in childhood (1994) (3)
- Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain (2020) (3)
- The water retention effects and action for atopic dermatitis-like symptoms of ethyl alcohol extract (from tamogi-take [Pleurotus corncopiae var. citrinopileatus] mushroom) on animal model of atopic dermatitis (2008) (3)
- Estimation of the Angles Migrating Cells Turn on Three-Dimensional Micro-Patterned Scaffolds by Live Cell Imaging with an Inverted Microscope (2014) (3)
- REGULATION OF CELL MIGRATION BY SPHINGOMYELIN SYNTHASES (2012) (3)
- Species-specific accumulation of ceramides in cerebrospinal fluid from encephalomyeloradiculoneurpathy patients associated with peripheral complement activation: A pilot study (2022) (3)
- Erratum: Targeting ceramide synthase 6–dependent metastasis-prone phenotype in lung cancer cells(Journal of Clinical Investigation(2016)126: (1()254–265)Doi:10.1172/JCI79775) (2019) (2)
- Inhibition of mouse B16 melanoma cell motility by sphingosine-1-phosphate. (1997) (2)
- Evaluation of Plant Ceramide Species-Induced Exosome Release from Neuronal Cells and Exosome Loading Using Deuterium Chemistry (2022) (2)
- A New Pathological Feature of Insulin Resistance and Type 2 Diabetes: Involvement of Ganglioside GM3 and Membrane Microdomains (2006) (2)
- Sphingosine Kinase 2 Inhibitor Accelerates Fas-Mediated Cell Death Progression in A20/2J Cells~!2008-08-07~!2008-09-19~!2008-11-28~! (2008) (2)
- Multiple Roles of Sms2 in White and Brown Adipose Tissues from Dietinduced Obese Mice (2018) (2)
- 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin (2012) (1)
- Pleckstrin Homology Domain Mediates Interaction Between Ceramide Kinase and Phosphatidylinositol 4,5-bisphosphate, Regulating Plasma Membrane Localization (2005) (1)
- Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. (2019) (1)
- A 3D Microfabricated Scaffold System for Unidirectional Cell Migration (2020) (1)
- Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation (2022) (1)
- [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. (2002) (1)
- [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. (2002) (1)
- Evaluation of chiral N,N-dimethyl-sphingosine for the interaction between nerve growth factor and tropomyosin receptor kinase A. (2022) (1)
- Penta-deuterium-labeled 4E, 8Z-sphingadienine for rapid analysis in sphingolipidomics study. (2022) (1)
- Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base (2006) (1)
- Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid ß-bound extracellular vesicles (2022) (1)
- [N-glycosylation of sphingosine 1-phosphate receptor, Edg-1, and its role on receptor internalization through membrane microdomain]. (2002) (1)
- Sphingomyelin synthase 2 is responsible for obesity and lipid droplet formation in liver and is a novel regulator of membrane microdomain (2011) (1)
- N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. (1995) (1)
- 2SC03 Relationship between the substrate specificities and lipid-microdomain localization of glycosyltransferases in Saccharomyces cerevisiae (2005) (0)
- Synthesis of very long-chain fatty acid and its relationship to sphingolipid metabolism (2009) (0)
- Autophagic Cell Death in Leukemia Cells Regulated by Ceramide and Sphingosine-1-Phosphate through Mammalian Target of Rapamycin. (2005) (0)
- Signaling Mechanisms for Positive and Negative Regulation of Cell Motility by Sphingosine-1-Phosphate Receptors (2006) (0)
- Changes in S 1 P 1 and S 1 P 2 expression during embryonal development and primitive endoderm differentiation of F 9 cells (2018) (0)
- New frontiers in sphingolipid biology. Preface. (2014) (0)
- [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. (1997) (0)
- of Tumor Cell-dependent Platelet Aggregation Potential of Murine B 16 Melanoma Cell Line through Blocking-Trimethylsphingosine on Metastatic N , N , N Inhibitory Effect of Cell Membrane Signaling as Target in Cancer Therapy II : Updated (2006) (0)
- Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet. (2020) (0)
- Diencephalic syndrome of emaciation: a case report with special reference to the mechanism of hypothalamic dysfunction. (1968) (0)
- Plasmalopsychosine and substances plasmalocerebroside and methods for treatment of neural diseases with these (1992) (0)
- TSH-Dependent Phosphatidylinositol Metabolism in the Thyroid : a Possible Role of the "Phosphoinositide Effect" (1981) (0)
- 3D Microfabricated Scaffolds: A 3D Microfabricated Scaffold System for Unidirectional Cell Migration (Adv. Biosys. 10/2020) (2020) (0)
- ELOVL7 is a fatty acid elongase exhibiting high activities toward C18-CoAs (2009) (0)
- [Signal transduction related to sphingosine 1-phosphate]. (1998) (0)
- Sdudies of SMS2 or CerK deficiency mice and their relations to diet-induced obesity and mast cell activation (2010) (0)
- The Phospholipase A1 Activity of Acyl‐Protein Thioesterase Links Platelet Activation to LPA Production During Blood Clotting (2011) (0)
- Front Cover: Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction (Eur. J. Org. Chem. 6/2017) (2017) (0)
- Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph (2021) (0)
- Identification of ABO blood group antigenｓ of glycosphingolipid and free oligosaccharide in serum (2017) (0)
- Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph (2020) (0)
- Understanding lipid-related orphan G protein-coupled receptors using activating GPCR mutations (2018) (0)
- Response of urinary beta-glucuronidase excretion to vasopressin with a possible abnormality in congenital nephrogenic diabetes insipidus. (1966) (0)
- Comprehensive Glycomic Approach Reveals Novel Low-Molecular-Weight Blood Group-Specific Glycans in Serum and Cerebrospinal Fluid. (2021) (0)
- Very Long-chain Fatty Acid Elongation 3-Hydroxyacyl-CoA Dehydratase Involved Acid Residues of Phs 1 , a Membrane Topology and Essential Amino Regulation , and Signaling : Lipids and Lipoproteins : Metabolism (2008) (0)
- Live Cell Migration Imaging on a Microfabricated Silicon Wafer (2017) (0)
- PO10SMS2 deficiency prevents diet-induced obesity (2010) (0)
- Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells. (2020) (0)
- [Biological significance of lactosylceramide branching and domain formation: glycosphingolipids govern gene expression]. (2002) (0)
- [Bioregulatory functions of methylsphingosines: in relation to sphingolipid signaling pathway and on approach of introducing sphingolipid-based drugs]. (1998) (0)
- Pathwayby the CXCL12/CXCR4 in Lipid Rafts Decreases Responsiveness Sphingomyelin Synthases: Sphingomyelin Regulation of Cell Migration by (2012) (0)
- Using N-methyl-sphingosine as an inhibitor of cell growth (1990) (0)
- [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. (2005) (0)
- [Sphingosine 1-phosphate in yeast]. (2002) (0)
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What Schools Are Affiliated With Yasuyuki Igarashi?
Yasuyuki Igarashi is affiliated with the following schools:
