Yimon Aye
Researcher
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Chemistry
Yimon Aye's Degrees
- PhD Chemistry University of Oxford
- Bachelors Chemistry University of Oxford
Why Is Yimon Aye Influential?
(Suggest an Edit or Addition)According to Wikipedia, Yimon Aye is an American chemist and molecular biologist. Currently she is an associate professor of chemistry at EPFL. Career Aye spent her early life in Burma. She completed her undergraduate studies in chemistry at the University of Oxford and obtained her master's degree in 2004. She joined Harvard University to study synthetic organic chemistry with David A. Evans, achieving her PhD in 2009. She then moved to Massachusetts Institute of Technology as a Damon Runyon Cancer Research Foundation fellow to work with JoAnne Stubbe. There she performed research into the regulatory mechanisms of ribonucleotide reductase. In 2012, she started as an assistant professor at Cornell University, where she began her work on redox-dependent cell signaling and genome maintenance pathways. During this time, she developed REX technologies, new methods to facilitate the study of unconventional electrophile-regulated stress signaling paradigms. REX technologies were one of the first approaches to forge direct links between upstream protein alteration by a reactive molecule and downstream responses.
Yimon Aye's Published Works
Published Works
- Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies (2014) (294)
- Redox Signaling by Reactive Electrophiles and Oxidants. (2018) (171)
- Copper-catalyzed asymmetric conjugate reduction as a route to novel beta-azaheterocyclic acid derivatives. (2004) (78)
- Vinyl-, propargyl-, and allenylsilicon reagents in asymmetric synthesis: a relatively untapped resource of environmentally benign reagents. (2009) (66)
- On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry (2016) (60)
- Clofarabine 5′-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit (2011) (57)
- Mechanistic Studies of Semicarbazone Triapine Targeting Human Ribonucleotide Reductase in Vitro and in Mammalian Cells (2012) (56)
- Privileged Electrophile Sensors: A Resource for Covalent Drug Development. (2017) (54)
- T-REX on-demand redox targeting in live cells (2016) (53)
- Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. (2013) (53)
- A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. (2015) (52)
- Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response (2014) (51)
- Akt3 is a privileged first responder in isozyme-specific electrophile response. (2017) (47)
- Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation. (2019) (42)
- Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses (2018) (40)
- Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. (2012) (40)
- Parallel kinetic resolution of tert-butyl (RS)-3-oxy-substituted cyclopent-1-ene-carboxylates for the asymmetric synthesis of 3-oxy-substituted cispentacin and transpentacin derivatives. (2008) (39)
- Enantioselective Scandium-Catalyzed Vinylsilane Additions: A New Approach to the Synthesis of Enantiopure β,γ-Unsaturated α-Hydroxy Acid Derivatives (2006) (37)
- Asymmetric, anti-selective scandium-catalyzed Sakurai additions to glyoxyamide. Applications to the syntheses of N-boc D-alloisoleucine and D-isoleucine. (2006) (37)
- β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. (2017) (34)
- Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals (2020) (34)
- Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. (2016) (27)
- Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles. (2019) (25)
- The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making (2016) (23)
- 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound (2018) (23)
- Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology. (2017) (22)
- Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor. (2018) (20)
- Aluminum-catalyzed enantio- and diastereoselective carbonyl addition of propargylsilanes. A new approach to enantioenriched vinyl epoxides. (2007) (16)
- Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3 (2018) (16)
- Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing (2020) (16)
- Precision Electrophile Tagging in Caenorhabditis elegans (2017) (16)
- Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators (2018) (16)
- Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera (2021) (14)
- Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1 (2019) (14)
- An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX. (2020) (14)
- Post‐transcriptional regulation of Nrf2‐mRNA by the mRNA‐binding proteins HuR and AUF1 (2019) (12)
- Genie in a bottle: controlled release helps tame natural polypharmacology? (2019) (11)
- Single‐Protein‐Specific Redox Targeting in Live Mammalian Cells and C. elegans (2018) (10)
- Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase. (2013) (9)
- Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales (2022) (8)
- Getting the right grip? How understanding electrophile selectivity profiles could illuminate our understanding of redox signaling. (2020) (8)
- Interrogating Precision Electrophile Signaling. (2019) (8)
- A Fluorimetric Readout Reporting the Kinetics of Nucleotide‐Induced Human Ribonucleotide Reductase Oligomerization (2014) (7)
- Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity (2019) (7)
- The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase. (2019) (6)
- Correction to Redox Signaling by Reactive Electrophiles and Oxidants. (2019) (6)
- Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities (2020) (6)
- Science's Response to CoVID‐19 (2021) (5)
- The mRNA-binding protein HuR is a kinetically-privileged electrophile sensor (2020) (5)
- Clofarabine commandeers the RNR-α—ZRANB3 nuclear signaling axis (2019) (4)
- Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery (2019) (4)
- REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins. (2020) (3)
- Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex (2008) (3)
- Prevalence and Associated Factors with Bovine Viral Diarrhoea Virus Antibodies in the Bulk Tank Milk of Small Scale Dairy Herds in Central Myanmar (2017) (2)
- Keap 1: the new Janus word on the block. (2022) (2)
- Weighing up the Selenocysteome Uncovers New Sec-rets. (2018) (2)
- Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. (2022) (1)
- Vinyl‐, Propargyl‐, and Allenylsilicon Reagents in Asymmetric Synthesis: A Relatively Untapped Resource of Environmentally Benign Reagents (2009) (1)
- Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes (2007) (1)
- The not so identical twins: (dis)similarities between reactive electrophile and oxidant sensing and signaling. (2021) (1)
- A primer on harnessing non-enzymatic post-translational modifications for drug design. (2021) (1)
- Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design? (2021) (1)
- Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed either Tissue-Specifically or Ubiquitously, and Recording the Resultant Functional Electrophile-Induced Redox Responses in Larval Fish (2022) (1)
- Structural Insights into Electrophiles and Electrophilic Metabolites Sensing and Signaling: The Missing Information (2023) (0)
- Enantioselective Scandium‐Catalyzed Vinylsilane Additions: A New Approach to the Synthesis of Enantiopure β,γ‐Unsaturated α‐Hydroxy Acid Derivatives. (2007) (0)
- Sc(III)-Catalyzed Vinylsilane Addition toN-Phenylglyoxamide (2006) (0)
- A Fluorimetric Readout Reporting the Kinetics of Nucleotide‐induced Human Ribonucleotide Reductase Oligomerization (2015) (0)
- Go to the Board: A Journey through the Life of Professor David A. Evans. (2022) (0)
- Redox Pathways in Chemical Toxicology. (2019) (0)
- A Novel Reductase‐Independent Role of Nuclear Ribonucleotide Reductase (2017) (0)
- Editorial overview: From the iceman to modern medicine. (2019) (0)
- Meeting Proceedings, 2017 Cornell University Baker Symposium-Quo Vadis: The Boundless Trajectories of Chemical Biology. (2017) (0)
- Earmarking Target‐Specific Redox Trajectories for Wound Healing in Zebrafish (2017) (0)
- Mechanistic Basis of Residue Specificity in Targeted Electrophilic Modification (2015) (0)
- Where Electrophile Signaling and Covalent Ligand-Target Mining Converge. (2020) (0)
- Finding a vocation for validation: taking proteomics beyond association and location (2022) (0)
- Targetable Reactive Electrophiles and Oxidants (T-REX) Technology to Identify "Privileged" Redox Sensors (2018) (0)
- Stay On Target: Deconvoluting Mixed Redox Messages through Precision Redox Targeting (2017) (0)
- Chemistry‐Driven Approaches to Deconstruct Redox‐Linked Signal Transduction Networks (2015) (0)
- b-TrCP 1 Is a Vacillatory Regulator of Wnt Signaling Graphical Abstract Highlights (2017) (0)
- anti-Selective Sc(III)-Catalyzed Sakurai Additions to Glyoxyamide (2006) (0)
- The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling (2021) (0)
- Empowering Global Chemical Biology at the Dawn of the New Decade. (2020) (0)
- Lipid‐derived electrophiles regulate isoform‐specific redox‐dependent kinase signaling (2017) (0)
- Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling (2019) (0)
- Deconvoluting Electrophile Signaling and Stress Response Pathways (2013) (0)
- Meeting Proceedings, 2017 Cornell University Baker Symposium-Quo Vadis: The Boundless Trajectories of Chemical Biology. (2017) (0)
- Oligomeric Regulation of Ribonucleotide Reductase (RNR) by Antileukemic Nucleotides (2015) (0)
- Precise Redox Responses Imprinted by On‐Demand Redox Targeting (2016) (0)
- Predicting gene-gene relationship with CNNC model (2021) (0)
- Another piece of the jigsaw: a new signaling axis defined by shape-specific RNR-α hexamers (2018) (0)
- Bringing Functional Context to Emerging Proximity-mapping Proteomics Tools (2022) (0)
- Z-REX uncovers a bifurcation in function of Keap1 paralogs (2022) (0)
- Enantioselective scandium-catalyzed vinylsilane additions: a new approach to the synthesis of enantiopure beta,gamma-unsaturated alpha-hydroxy acid derivatives. (2006) (0)
- Hiding in Plain Sight: The Issue of Hidden Variables. (2022) (0)
- The Day the Classroom Flipped: Lessons Learned from Interdisciplinary Science Education Online (2022) (0)
- New Account Articles to Support and Promote the Next Generation of Leaders in Chemical Biology. (2022) (0)
- Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation (2022) (0)
- Breaking the fourth wall: Quaternary organizations forge a link to the novel non‐enzymatic function of RNR‐α (2016) (0)
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