Yoshiaki Kiso
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Computer Science
Yoshiaki Kiso's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Yoshiaki Kiso's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. (1990) (332)
- Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes (2001) (274)
- Atrial natriuretic polypeptide: Topographical distribution in the rat brain by radioimmunoassay and immunohistochemistry (1985) (265)
- Alpha-human atrial natriuretic polypeptide is released from the heart and circulates in the body. (1985) (226)
- Phosphate removal and recovery with a synthetic hydrotalcite as an adsorbent. (2006) (222)
- NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent (2006) (217)
- Rejection properties of non-phenylic pesticides with nanofiltration membranes (2000) (215)
- Occurrence of atrial natriuretic polypeptide in brain. (1985) (184)
- PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model (2006) (174)
- Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization (2007) (169)
- Rejection properties of alkyl phthalates with nanofiltration membranes (2001) (161)
- Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides. (2004) (155)
- The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design. (2001) (148)
- Paclitaxel prodrugs: toward smarter delivery of anticancer agents. (2006) (147)
- Wastewater treatment performance of a filtration bio-reactor equipped with a mesh as a filter material (2000) (138)
- Radioimmunoassay for α-human and rat atrial natriuretic polypeptide (1984) (134)
- The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice (2006) (133)
- Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272. (1996) (133)
- Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine. (1992) (122)
- Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine. (1995) (117)
- Analysis of pesticides in environmental water samples by solid-phase micro-extraction-high-performance liquid chromatography. (1996) (115)
- Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography (2009) (112)
- Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective (2006) (112)
- High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor. (2003) (98)
- click peptide based on the O-acyl isopeptide method : Control of Aβ1 42 production from a photo-triggered Aβ1 42 analogue (2006) (94)
- Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor (2000) (91)
- Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. (1998) (89)
- Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability. (2005) (89)
- Effect of molecular charges on renal uptake of 111In-DTPA-conjugated peptides. (2001) (89)
- Synthesis of Palmitoyl Derivatives of Insulin and Their Biological Activities (1989) (85)
- Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction. (1990) (80)
- Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method (1993) (78)
- Fiber-in-tube solid-phase microextraction: a fibrous rigid-rod heterocyclic polymer as the extraction medium (2000) (77)
- A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel. (2003) (75)
- KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. (1991) (75)
- KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides. (2003) (75)
- Rejection properties of pesticides with a hollow fiber NF membrane (HNF-1) (2002) (74)
- The ‘O‐acyl isopeptide method’ for the synthesis of difficult sequence‐containing peptides: application to the synthesis of Alzheimer's disease‐related amyloid β peptide (Aβ) 1–42 (2005) (74)
- Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure. (2012) (73)
- Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. (2002) (72)
- Design and synthesis of a novel water-soluble Aβ1-42 isopeptide: an efficient strategy for the preparation of Alzheimer's disease-related peptide, Aβ1-42, via O–N intramolecular acyl migration reaction (2004) (72)
- Development of O-acyl isopeptide method. (2007) (70)
- Avidin-biotin affinity columns. General methods for attaching biotin to peptides and proteins (1978) (69)
- Miniaturized solid-phase extraction as a sample preparation technique for the determination of phthalates in water (2002) (67)
- ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence‐containing bioactive peptides (2004) (66)
- Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases (2008) (65)
- Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins (1994) (63)
- Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs. (2008) (63)
- Coupling of sequencing batch reactor and mesh filtration: operational parameters and wastewater treatment performance. (2005) (62)
- Effect of molecular shape on rejection of uncharged organic compounds by nanofiltration membranes and on calculated pore radii (2010) (62)
- KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. (2004) (62)
- Total synthesis of anti-microtubule diketopiperazine derivatives: phenylahistin and aurantiamine. (2000) (60)
- Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. (1999) (60)
- “Click Peptides”—Chemical Biology‐Oriented Synthesis of Alzheimer's Disease‐Related Amyloid β Peptide (Aβ) Analogues Based on the “O‐Acyl Isopeptide Method” (2006) (60)
- Efficient removal of N-benzyloxycarbonyl group by a ‘push–pull’ mechanism using thioanisole–trifluoroacetic acid, exemplified by a synthesis of Met-enkephalin (1980) (59)
- Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres. (2006) (59)
- Disulfide Bond Formation Using the Silyl Chloride-Sulfoxide System for the Synthesis of a Cystine Peptide (1992) (58)
- The effects of molecular width on permeation of organic solute through cellulose acetate reverse osmosis membranes (1992) (58)
- Pore radius estimation based on organic solute molecular shape and effects of pressure on pore radiu (2011) (57)
- Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere. (1996) (57)
- “Click Peptide“: pH‐Triggered in Situ Production and Aggregation of Monomer Aβ1–42 (2009) (56)
- A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV‐1 protease (2004) (55)
- Development of first photoresponsive prodrug of paclitaxel. (2006) (55)
- ‘O-Acyl isopeptide method’ for the efficient synthesis of difficult sequence-containing peptides: use of ‘O-acyl isodipeptide unit’ (2006) (54)
- Efficient coupling of α,α-dimethyl amino acid using a new chloro imidazolidium reagent, CIP (1994) (53)
- Significance of α‐Human Atrial Natriuretic Polypeptide as a Hormone in Humans (1986) (52)
- Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements (1980) (52)
- Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. (2006) (52)
- Wastewater treatment performance and sludge reduction properties of a household wastewater treatment system combined with an aerobic sludge digestion unit (2008) (51)
- Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo. (1998) (50)
- Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. (2009) (50)
- New human renin inhibitors containing an unnatural amino acid, norstatine. (1988) (50)
- Recent progress in the drug discovery of non-peptidic BACE1 inhibitors (2009) (50)
- beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells. (2006) (49)
- Factors affecting adsorption of organic solutes on cellulose acetate in an aqueous solution system (1986) (49)
- How Much Binding Affinity Can be Gained by Filling a Cavity? (2010) (49)
- Isolation of a novel analgesic pentapeptide, neo-kyotorphin, from bovine brain. (1982) (49)
- Synthesis of di- and tripeptide analogues containing alpha-ketoamide as a new core structure for inhibition of HIV-1 protease. (2000) (48)
- Existence of atrial natriuretic polypeptide in kidney. (1985) (48)
- Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety (2012) (47)
- Application of the O-N intramolecular acyl migration reaction in medicinal chemistry. (2007) (47)
- Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro (2008) (45)
- Atrial natriuretic peptide antagonists: biological evaluation and structural correlations. (1990) (44)
- Bound Water Molecules at the Interface between the HIV-1 Protease and a Potent Inhibitor, KNI-272, Determined by NMR (1996) (43)
- Novel non-peptidic and small-sized BACE1 inhibitors. (2008) (43)
- New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration. (2002) (42)
- The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. (2006) (42)
- Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic. (1999) (41)
- Flexibility and Function in HIV Protease: Dynamics of the HIV-1 Protease Bound to the Asymmetric Inhibitor Kynostatin 272 (KNI-272) (1998) (41)
- New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors (2009) (41)
- HIV protease inhibitors: peptidomimetic drugs and future perspectives. (2002) (40)
- Search for substrate‐based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II (2004) (39)
- Specific binding activities and cyclic GMP responses by atrial natriuretic polypeptide in kidney epithelial cell line (LLC-PK1). (1985) (39)
- Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere. (2000) (39)
- Convergent Synthesis of (−)-Mirabazole C Using a Chloroimidazolidium Coupling Reagent, CIP (1996) (38)
- Acidogenic fermentation of blended food‐waste in combination with primary sludge for the production of volatile fatty acids (2005) (38)
- Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin. (1994) (38)
- Solventless sample preparation procedure for organophosphorus pesticides analysis using solid phase microextraction and on-line supercritical fluid extraction/high performance liquid chromatography technique (2001) (37)
- Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum. (2011) (37)
- "O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH. (2007) (37)
- Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study (2013) (37)
- The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors (2012) (37)
- No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions. (2005) (36)
- Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage. (2003) (36)
- [An approach to the targeted attachment of peptides and proteins to solid supports]. (1976) (36)
- Small-sized BACE1 inhibitors (2006) (36)
- Anchoring of Fmoc amino acid to 4-alkoxybenzyl alcohol resin using a new esterification reagent (1992) (36)
- Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents. (2012) (36)
- BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety. (2008) (35)
- Liquid chromatography in a capillary packed with fibrous cellulose acetate (1986) (34)
- Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study. (2004) (34)
- Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors (2006) (34)
- Studies on peptides. L. Acidolysis of protecting groups in peptide chemistry by fluorosulphonic acid and methanesulphonic acid. (1975) (34)
- Conventional and high-yield synthesis of DTPA-conjugated peptides: application of a monoreactive DTPA to DTPA-D-Phe1-octreotide synthesis. (1997) (34)
- Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases (2004) (34)
- Controlled Production of Amyloid β Peptide from a Photo‐Triggered, Water‐Soluble Precursor “Click Peptide“ (2008) (34)
- Macrocyclization on solid support using Heck reaction (1997) (33)
- 'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants. (2005) (32)
- Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer's disease: progress and problems. (2006) (32)
- Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV. (2008) (32)
- Cellulose acetate as stationary phase in microcolumn LC (1989) (32)
- 'O-Acyl isopeptide method' : racemization-free segment condensation in solid phase peptide synthesis (2006) (32)
- Excess sludge reduction performance of an aerobic SBR process equipped with a submerged mesh filter unit (2006) (31)
- Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold. (2009) (31)
- Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats (2000) (31)
- Bacteria of the Candidate Phylum TM7 are Prevalent in Acidophilic Nitrifying Sequencing-Batch Reactors (2014) (31)
- Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor. (2001) (31)
- Advances in the identification of β-secretase inhibitors (2013) (30)
- Pesticide analysis by high-performance liquid chromatography using the direct injection method (1996) (30)
- O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids. (2003) (30)
- Cellulose Acetate Fiber as Stationary Phase in Capillary Electrochromatography (1998) (29)
- ‘O‐Acyl isopeptide method’ for peptide synthesis: Solvent effects in the synthesis of Aβ1–42 isopeptide using ‘O‐acyl isodipeptide unit’ (2007) (29)
- Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin. (2010) (29)
- ‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues (2006) (29)
- Rejection properties of aromatic pesticides with a hollow-fiber NF membrane (2005) (28)
- Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine (1989) (28)
- Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions. (2010) (28)
- KNI‐577, a Potent Small‐Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition‐State Mimic (1998) (28)
- Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers. (2001) (27)
- 'Double-Drugs'--a new class of prodrug form of an HIV protease inhibitor conjugated with a reverse transcriptase inhibitor by a spontaneously cleavable linker. (2000) (26)
- New directions for protease inhibitors directed drug discovery (2016) (26)
- CONVERGENT SYNTHESIS OF DOLASTATIN 15 BY SOLID PHASE COUPLING OF AN N-METHYLAMINO ACID (1998) (26)
- Chemical cleaning of reverse osmosis membranes used for treating wastewater from a rolling mill process (2006) (26)
- Immunohistochemical demonstration of α-atrial natriuretic polypeptide-containing neurons in the rat brain (2004) (25)
- Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. (2008) (25)
- Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions (2005) (25)
- Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic. (2004) (25)
- Deprotection of O-methyltyrosine by a ‘push–pull’ mechanism using the thioanisole–trifluoromethanesulphonic acid system. Application to the convenient synthesis of a potent N-methylenkephalin derivative (1979) (25)
- Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties. (2007) (25)
- Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor. (2003) (25)
- O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids. (2006) (24)
- Studies on Peptides, XXXIX. N-Isobutoxycarbonyl-2-alkoxy-1, 2-dihydroquinoline Derivatives, as Coupling Reagents in Peptide Synthesis (1973) (24)
- Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates. (2001) (24)
- Removal properties of arsenic compounds with synthetic hydrotalcite compounds (2005) (24)
- Rejection properties of NF membranes for alkylphenols (2007) (24)
- Fibrous stationary phase in capillary electrochromatography. (2001) (23)
- Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters. (2018) (23)
- Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease. (2010) (23)
- 2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline as a coupling reagent in peptide synthesis (1972) (23)
- Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1. (2011) (23)
- Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. (2008) (23)
- Novel Dextranase Catalyzing Cycloisomaltooligosaccharide Formation and Identification of Catalytic Amino Acids and Their Functions Using Chemical Rescue Approach* (2012) (23)
- Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design. (2012) (22)
- Synthesis of cystine-peptide by a new disulphide bond-forming reaction using the siiyl chloride–sulphoxide system (1991) (22)
- Efficient synthesis of peptaibol using a chloroimidazolidium coupling reagent, CIP (1997) (22)
- Discovery of Mitocryptide-1, a Neutrophil-activating Cryptide from Healthy Porcine Heart* (2008) (22)
- Retention characteristics of aliphatic compounds on cellulose acetates as a stationary phase with an aqueous mobile phase (1989) (22)
- Determination of Bisphenol A in Water Using a Packed Needle Extraction Device (2009) (21)
- Trials of lipid modification of peptide hormones for intestinal delivery (1992) (21)
- Bestatin potentiates the antinociception but not the motor dysfunction induced by intracerebrally administered dynorphin-B in mice (1989) (21)
- An ‘active ester’-type mixed anhydride method for peptide synthesis. Use of the new reagent, norborn-5-ene-2,3-dicarboximido diphenyl phosphate (NDPP) (1980) (21)
- BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor? (2012) (21)
- Visual determination of nitrite and nitrate in waters by color band formation method. (2006) (21)
- Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological Activity (1991) (20)
- Deprotection of the S-trimethylacetamidomethyl (Tacm) group using silver tetrafluoroborate: application to the synthesis of porcine brain natriuretic peptide-32 (pBNP-32). (1990) (20)
- A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions (2004) (20)
- Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. (2007) (20)
- Regioselective double disulfide formation using silylchloride-sulfoxide system (1992) (20)
- Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors. (2011) (19)
- The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active. (2014) (19)
- Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents (2008) (19)
- Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole. (2011) (19)
- Convergent synthesis of (−)-mirabazole B using a chloroimidazolidium coupling reagent, CIP (1997) (19)
- Fmoc-based solid-phase peptide synthesis using a new t-alcohol type 4-(1′,1′-dimethyl-1′-hydroxypropyl)phenoxyacetyl handle (DHPP)–resin (Fmoc = fluoren-9-ylmethoxycarbonyl) (1990) (19)
- Adsorption properties of cyclic compounds on cellulose acetate (1999) (19)
- Analysis of Amide Bond Formation with an α-Hydroxy-β-amino Acid Derivative, 3-Amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone (2001) (18)
- Accelerated natriuresis induced by synthetic atrial natriuretic polypeptide in spontaneously hypertensive rats. (1985) (18)
- Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket. (2009) (18)
- Studies on Peptides. XXX. Trichloroethyloxycarbonylhydrazine (1971) (18)
- Sludge thickening performance of mesh filtration process. (2004) (18)
- Total synthesis of (+)-negamycin and its 5-epi-derivative (2010) (18)
- Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation. (2009) (17)
- Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position. (2012) (17)
- Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor. (2012) (17)
- Inhibition by KMI‐574 leads to dislocalization of BACE1 from lipid rafts (2009) (17)
- Mitocryptide-2: Purification, Identification, and Characterization of a Novel Cryptide That Activates Neutrophils 1 (2009) (17)
- Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases. (2008) (17)
- Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. (2010) (17)
- Significance of (111)In-DTPA chelate in renal radioactivity levels of (111)In-DTPA-conjugated peptides. (2001) (17)
- A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE (1989) (17)
- Studies on peptides. XLIV. Synthesis of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) by the fragment condensation procedure on polymer support. (1974) (17)
- Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (1999) (17)
- Tripeptides acting on opioid receptors in rat colon. (1984) (17)
- Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide (1983) (17)
- Total synthesis of thiangazole (1999) (17)
- Isopeptide method: development of S‐acyl isopeptide method for the synthesis of difficult sequence‐containing peptides (2008) (17)
- Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor. (2001) (17)
- Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. (2000) (17)
- Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme. (2008) (17)
- O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation. (2009) (16)
- Switching from the unfolded to the folded state of the helix‐loop‐helix domain of the Id proteins based on the O‐acyl isopeptide method (2008) (16)
- A new reductive acidolysis final deprotection strategy in solid phase peptide synthesis. Use of a new safety-catch linker (1994) (16)
- Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors. (2007) (16)
- EFFICIENT SOLID PHASE PEPTIDE SYNTHESIS ON A PHENACYL-RESIN BY A METHANESULFONIC ACID α-AMINO DEPROTECTING PROCEDURE (1990) (16)
- Novel β-amyloid aggregation inhibitors possessing a turn mimic. (2015) (16)
- Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element (2011) (15)
- Comparison of a new orally potent tripeptide HIV‐1 protease inhibitor (anti‐aids drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations (1993) (15)
- Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine (1978) (15)
- Efficient deprotection of NG-tosylarginine with a thioanisole–trifluoromethanesulphonic acid system (1980) (15)
- DESIGN AND SYNTHESIS OF A COVALENTLY LINKED HIV-1 PROTEASE DIMER ANALOG AND PEPTIDOMIMETIC INHIBITORS (1998) (15)
- Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides (2009) (15)
- Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: determined by NMR spectroscopy and simulated annealing calculations. (1996) (15)
- Synthesis of the heptadecapeptide corresponding to the entire amino acid sequence of salmon melanin-concentrating hormone (MCH). (1984) (15)
- Tetrafluoroboric acid as a useful deprotecting reagent in Fmoc-based solid-phase peptide syntheses (Fmoc = fluoren-9-ylmethoxycarbonyl) (1990) (15)
- Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C. (2012) (15)
- A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor. (1999) (15)
- Syndyphalin SD‐25: a higly selective ligand for μ opiate receptors (1982) (15)
- Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum. (2011) (15)
- Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor. (2012) (15)
- A new class of amino protecting group removable by reductive acidolysis: the 4-methylsulphinylbenzyloxycarbonyl (Msz) group (1989) (15)
- Synthesis of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) by fragment condensation on a polymer support (1974) (14)
- Pharmacokinetic study of a tripeptide HIV‐1 protease inhibitor, KNI‐174, in rats after intravenous and intraduodenal administrations (1993) (14)
- Adsorption properties of aromatic compounds on polyethylene as a membrane material (1999) (14)
- Morphine‐like activities of synthetic enkephalin analogues (1981) (14)
- Fluoren-9-ylmethyloxycarbonyl (Fmoc) amino acid chloride as an efficient reagent for anchoring Fmoc amino acid to 4-alkoxybenzyl alcohol resin. (1990) (14)
- Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties. (2008) (14)
- A spot test for aqueous phosphate by color band formation (2002) (14)
- Synthesis of porcine brain natriuretic peptide-32 using silver tetrafluoroborate as a new deprotecting reagent of the S-trimethylacetamidomethyl group. (1990) (14)
- Solution structure of HIV-1 protease-allophenylnorstatine derivative inhibitor complex obtained from molecular dynamics simulation. (1994) (14)
- A new thiol protecting trimethylacetamidomethyl group. Synthesis of a new porcine brain natriuretic peptide using the S-trimethylacetamidomethyl-cysteine (1989) (14)
- Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy. (2012) (13)
- Synthesis and activity of C-terminal heptapeptides of tachykinins and bombesin-like peptides. (1979) (13)
- Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide (2011) (13)
- Elucidation of structural requirements of mastoparan for mast cell activation-toward the comprehensive prediction of cryptides acting on mast cells. (2008) (13)
- New hydroxyl protecting groups of a safety-catch type removable by reductive acidolysis. (1991) (13)
- A fluoride ion deprotection strategy in peptide synthesis. Combination with selective deprotection using the dilute methanesulfonic acid of alpha-amino protecting groups. (1988) (13)
- Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272. (2008) (13)
- A HPLC study of adsorption of organic solutes on cellulose acetate. (1985) (13)
- SYNTHESIS OF HUMAN ENDOTHELIN-1 BY REGIOSELECTIVE DISULFIDE FORMATION USING THE SILYL CHLORIDE-SULFOXIDE SYSTEM (1995) (12)
- Click Peptide Concept: O‐Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule (2011) (12)
- Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP (1995) (12)
- Syndyphalin, an enkephalin-like peptide with prolonged subcutaneous analgesic activity. (1981) (12)
- Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position. (2013) (12)
- DMF Decomposition and Nitrogen Removal Performance by a Mesh-Filtration Bioreactor under Acidic Conditions (2009) (12)
- DETERMINATION OF THE RATE OF MONOMER INTERCHANGE IN A LIGAND-BOUND HOMODIMERIC PROTEIN FROM NOESY CROSS PEAKS : APPLICATION TO THE HIV PROTEASE/KNI-52 9 COMPLEX (1999) (12)
- Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles. (2011) (12)
- Studies on peptides. LIX. Synthesis of the nonatriacontapeptide corresponding to the entire amino acid sequence of porcine adrenocorticotropic hormone. (1976) (12)
- 'Click peptide' using production of monomer Aβ from the O-acyl isopeptide: application to assay system of aggregation inhibitors and cellular cytotoxicity. (2011) (12)
- Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. (2007) (11)
- Mitochondrial protein‐derived cryptides: Are endogenous N‐formylated peptides including mitocryptide‐2 components of mitochondrial damage‐associated molecular patterns? (2016) (11)
- Solvent Effects on Stereo and Regioselectivities of Ring-opening Reaction of Epoxide with Aluminum Chloride (1976) (11)
- Pesticides Separation by Nanofiltration Membranes. (1996) (11)
- Trimethylacetamidomethyl (Tacm) Group, a New Protecting Group for the Thiol Function of Cysteine (1990) (11)
- A deblocking method using thioether-sulfonic acid systems. Application to the synthesis of met-enkephalin. (1979) (11)
- A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide. (2013) (11)
- Synthesis of [27-Tyr]-cholecystokinin-pancreozymin (CCK-PZ). (1976) (11)
- Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid. (2007) (11)
- Epimerization‐free synthesis of cyclic peptide by use of the O‐acyl isopeptide method (2010) (11)
- A reductive acidolysis final deprotection strategy in solid phase peptide synthesis based on safety-catch protection. (1997) (11)
- Synthesis of amyloid beta peptide 1-42 (E22Delta) click peptide: pH-triggered in situ production of its native form. (2009) (10)
- Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. (2018) (10)
- Binding characteristics of KNI-272 to plasma proteins, a new potent tripeptide HIV protease inhibitor. (1996) (10)
- Identification and endothelin‐induced activation of multiple extracellular signal‐regulated kinases in aortic smooth muscle cells (1992) (10)
- The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, KNI-272, in beagle dogs. (1996) (10)
- Studies on Peptides. XXVIII. Synthesis of the Docosapeptide which Embodies the Entire Amino Acid Sequence of β-Melanocyte-stimulating Hormone from Human Pituitary Gland (1970) (10)
- Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere. (2003) (10)
- Syndyphalin‐33, a synthetic tripeptide alkylamide with prolonged analgesic activity (1981) (10)
- A practical synthesis of the [(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl]-L-histidine moiety (P4-P2) in renin inhibitors (1990) (10)
- Efficient solid phase peptide synthesis (2009) (10)
- Crystal Growth Procedure of HIV-1 Protease-Inhibitor KNI-272 Complex for Neutron Structural Analysis at 1.9 Å Resolution (2010) (10)
- PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN (1983) (10)
- Molecular sieving effects of disk-shaped molecules on reverse osmosis and nanofiltration separation (2017) (10)
- A Fluorogenic Probe for γ‐Glutamyl Cyclotransferase: Application of an Enzyme‐Triggered O‐to‐N Acyl Migration‐Type Reaction (2013) (9)
- Synthesis of O-acyl isopeptides. (2013) (9)
- Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position. (2014) (9)
- The effect of co-existing solutes on arsenate removal with hydrotalcite compound. (2010) (9)
- A spot test for ammonium ion by the color band formation method. (2007) (8)
- Synthesis and conformation of an analog of the helix‐loop‐helix domain of the Id1 protein containing the O‐acyl iso‐prolyl‐seryl switch motif (2010) (8)
- Tetrafluoroboric acid, a useful deprotecting reagent in peptide synthesis. (1989) (8)
- Establishment of a biological assay system for human retroviral protease activity. (2005) (8)
- Aspartic protease inhibitors as drug candidates for treating various difficult-to-treat diseases (2014) (8)
- Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV‐1 protease inhibitor, KNI‐272, in rats after intravenous administration (1994) (8)
- Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights (2018) (8)
- Design, synthesis, and biophysical properties of a helical Abeta1-42 analog: Inhibition of fibrillogenesis and cytotoxicity. (2008) (7)
- Syntheses and biological activities of atrial natriuretic polypeptide analogs (1987) (7)
- Design and synthesis of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic. (1995) (7)
- Detection tube method for trace level arsenic (2015) (7)
- Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors. (2011) (7)
- "Click peptide" based on the "o-acyl isopeptide method": control of A beta1-42 production from a photo-triggered A beta1-42 analogue. (2006) (7)
- Application of plug–plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin‐binding fragments selected from a digested mixture of reduced BSA (2014) (7)
- Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (2004) (7)
- Verification of protein disulfide bond arrangement by in‐gel tryptic digestion under entirely neutral pH conditions (2010) (7)
- Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells. (2008) (7)
- Design and Synthesis of Potent β-Secretase (BACE1) Inhibitors with P′1 Carboxylic Acid Bioisosteres. (2006) (7)
- Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors. (2011) (7)
- Total Synthesis of Antimicrotubule Diketopiperazine Derivatives: Phenylahistin and Aurantiamine. (2001) (6)
- Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the Nim-Function of Histidine (1980) (6)
- An online solid phase extraction method for the determination of ultratrace level phosphate in water with a high performance liquid chromatograph (2014) (6)
- Synthesis of novel amino acids, l-bis-tetrahydrofuranylglycines (2002) (6)
- Structure--activity relationship of fluorine-containing renin inhibitory peptides based upon the tertiary structure of human renin. (1988) (6)
- An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease. (2002) (6)
- S‐acyl isopeptide method: Use of allyl‐type protective group for improved preparation of thioester‐containing S‐acyl isopeptides by Fmoc‐based SPPS (2011) (5)
- Tyrosine in position 4 is the key amino acid for the binding of angiotensin II to human arteriolar receptor. (1987) (5)
- Biological removal characteristics of phenol with filtration bio-reactor (2015) (5)
- Super-active enkephalin analogues (1981) (5)
- A spot test for nitrite and nitrate detection by color band length and number of colored zebra-bands formed in a mini-column (2010) (5)
- Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum. (2014) (5)
- Synthesis and analgesic activity of neo-kyotorphin analogs. (1985) (5)
- N im -p-methoxyphenylsulphonylhistidine, a new derivative for peptide synthesis (1979) (5)
- Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5,8-dioxo-4,7-diazanonanoyl]-N-tert-butyl-1,3-thiazolidine-4-carboxamide. (2004) (5)
- Ammonium detection by formation of colored zebra-bands in a detecting tube. (2010) (5)
- Synthesis of rat brain natriuretic peptide 45 using tetrafluoroboric acid deprotection and silyl chloride disulfide formation. (1993) (5)
- Oligoarginine-based prodrugs with self-cleavable spacers for caco-2 cell permeation. (2008) (5)
- 2 – Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis (1995) (5)
- Targets of a protease inhibitor, KNI‐272, in HIV‐1‐infected cells (2001) (5)
- A New Class of Anti‐HIV Agents: Synthesis and Activity of Conjugates of HIV Protease Inhibitors with a Reverse Transcriptase Inhibitor. (1999) (4)
- New human renin inhibitory peptides: angiotensinogen transition-state analogues containing novel Leu-Val replacement and a retro-inverso amide bond. (1988) (4)
- Synthesis of human C-type natriuretic peptide 22 using chlorotrityl resin and tetrafluoroboric acid deprotection. (1996) (4)
- Erratum to “Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin” [Bioorg. Med. Chem. 16 (2008) 10049–10060] (2009) (4)
- Organic Chemistry and Medicinal Chemistry Based on α-Hydroxy-β-amino Acids (2005) (4)
- Development of [Ile40]HTLV‐I protease inhibition assay using novel fluorogenic and chromogenic substrate (2011) (4)
- Generation of monoclonal antibodies against mitocryptide‐2: toward a new strategy to investigate the biological roles of cryptides (2017) (4)
- Solution-phase synthesis of porcine brain natriuretic peptide (pBNP) using S-trimethylacetamidomethylcysteine. (1990) (4)
- Tetrapeptides, as small‐sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1 (2010) (4)
- Studies on peptides. XLIII. Synthesis of two protected peptides related to the C-terminal portion of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (4)
- Synthesis and activity of a newly isolated analgesic pentapeptide, neo-kyotorphin. (1983) (4)
- Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-1. (2015) (4)
- Absorption of new HIV‐1 protease inhibitor, KNI‐272, after intraduodenal and intragastric administrations to rats: Effect of solvent (1995) (4)
- Studies on Peptides. XXXI. Synthesis of Two Model Pentapeptides related to Clostridial Ferredoxin (1971) (4)
- Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region. (2005) (4)
- Synthesis and biological evaluation of a 13N-labeled opioid peptide. (1992) (4)
- Nutrient Loss from a Tea Plantation Area in Japan (2009) (4)
- Studies on Peptides. XXIX. p-Methoxybenzyl Mixed Carbonates (1970) (4)
- [Anti-HIV compounds]. (1993) (4)
- KNI-272, a highly selective and potent peptidic HIV protease inhibitor. (2001) (4)
- N in -Diphenylphosphinothioyltryptophan, a useful derivative for peptide synthesis by the methanesulphonic acid–thioanisole system and fluoride ion deprotection methods (1988) (4)
- Structure of HIV-1 protease with KNI-272: a transition state mimetic inhibitor containing allophenylnorstatine. (1995) (4)
- Discovery of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease (2017) (3)
- Removal of phosphite and sulfate from electroless nickel–phosphorus plating bath with hydrotalcite for the management of watershed (2013) (3)
- “Click Peptides” — Chemical Biology‐Oriented Synthesis of Alzheimer′s Disease‐Related Amyloid β Peptide (Aβ) Analogues Based on the “O‐Acyl Isopeptide Method” (2006) (3)
- Fibrous adsorbent for removal of aqueous aromatic hydrocarbons. (2007) (3)
- An approach to the targeted attachment of peptides and proteins to solid supports. (1976) (3)
- Studies on peptides. LXVII. Synthesis of the hexadecapeptide corresponding to position 1 through 16 of porcine cholecystokinin-pancreozymin (CCK-PZ). (1976) (3)
- Acid‐Catalyzed Monodehydro‐2,5‐diketopiperazine Formation from N‐α‐Ketoacyl Amino Acid Amides. (2009) (3)
- A deprotection method using tetrachlorosilane-trifluoroacetic acid scavengers by a ‘reductive acidolysis’ mechanism: Application to the synthesis of a novel tachykinin peptide, scyliorhinin I (1988) (3)
- Effect of Composition and Structure of Coating Polymers on Moisture Transporting Properties in Waterproof/Moisture-permeable Fabrics Prepared by Wet-Coagulation Process (1996) (3)
- Analysis of amide bond formation with an alpha-hydroxy-beta-amino acid derivative, 3-amino-2-hydroxy-4-phenylbutanoic acid, as an acyl component: byproduction of homobislactone. (2001) (3)
- A Novel Dipeptide‐based HIV Protease Inhibitor Containing Allophenylnorstatine (2004) (3)
- Effect of properties of feed solution on transport of inorganic solutes in reverse osmosis. (1978) (3)
- A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate (1990) (3)
- A new stepwise deprotection method using reductive acidolysis followed by fluoride ion in solid phase peptide synthesis (1993) (3)
- A membrane extraction method for trace level phosphate analysis (2015) (3)
- Effects of Water Deprivation and Sodium Load on Atrial Natriuretic Polypeptide in Rat Brain (1986) (3)
- Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages (2021) (3)
- Studies on Peptides. XXXV. Some p-Methoxybenzyloxycarbonyl-Amino Acid Derivatives (1973) (3)
- Solution syntheses of two enkephalin-containing peptides, peptide E and dynorphin(1-24), using Nin-(2,4,6-triisopropylphenylsulfonyl)tryptophan. (1989) (3)
- Corrigendum to Significance of interactions of BACE1―Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold (2009) (3)
- Syndyphalin SD‐25: A highly selective ligand for μ opiate receptors (1982) FEBS Letters 141,203–206. (1982) (3)
- Racemization-free segment condensation based on the O-acyl isopeptide method: toward a chemical protein synthesis on solid support. (2009) (2)
- Deprotecting Reagents : SiCl4-CF3COOH-Scavenger (1990) (2)
- Synthesis of a newly isolated opioid tridecapeptide, rimorphin, from pituitary using a trifluoroacetic acid-thioanisole deprotection system. (1983) (2)
- Delivery of Peptide Drugs (2015) (2)
- Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis (1996) (2)
- Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP). (1990) (2)
- Antiinflammatory effects of opioid peptides and opiates on dextran-induced eduma in rat paw (1984) (2)
- O‐Acyl isopeptide method: development of an O‐acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1‐42 isopeptide (2014) (2)
- Total Synthesis of Human Insulin by Regioselective Disulfide Formation Using the Silyl Chloride-Sulfoxide Method. (1994) (2)
- Waste sludge reduction with a pilot-scale membrane bioreactor for point source pollution management (2013) (2)
- Rational Drug Design of HTLV-I Protease Inhibitors (2009) (2)
- EFFICIENT REMOVAL OF PROTECTING GROUPS BY A ′PUSH‐PULL′ MECHANISM. II. DEPROTECTION OF O‐BENZYLTYROSINE WITH A THIOANISOLE‐TRIFLUOROACETIC ACID SYSTEM WITHOUT O‐TO‐C REARRANGEMENTS (1980) (2)
- Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin (2005) (2)
- Medicinal Chemistry of α‐Hydroxy‐β‐Amino Acids (2011) (2)
- Total Synthesis of (-)-Mirabazole B Using a Chloroimidazolidium Reagent, CIP (1996) (2)
- Comparative properties of Aβ1-42, Aβ11-42, and [Pyr¹¹]Aβ11-42 generated from O-acyl isopeptides. (2013) (2)
- Structure-activity relationships of atrial natriuretic factor (ANF) receptor agonists (1990) (2)
- Analgesic and other pharmacological activities of an enkephalin analogue, syndyphalin (SD)-25. (1982) (2)
- Phosphorus Removal with Hydrotalcite Compound (2002) (2)
- Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors (2009) (2)
- Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum (2004) (2)
- Advanced Treatment of Night Soil with Membrane Separation Process (1990) (2)
- KNI‐272, a Highly Selective and Potent Peptidic HIV Protease Inhibitor (2010) (2)
- Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner. (2014) (2)
- A new two-dimensional protection strategy for solid phase peptide synthesis: Use of a safety-catch type of ester linkage-resin cleavable by reductive acidolysis (1992) (2)
- Studies on Peptides. XXV. A Convenient Procedure for the Preparation of p-Methoxybenzyl Azidoformate (1969) (2)
- Discovery of Peptide Drugs as Enzyme Inhibitors and Activators (2015) (2)
- Convergent Synthesis of (‐)‐Mirabazole B (XII) Using a Chloroimidazolidium Coupling Reagent, CIP. (1997) (1)
- SYNTHESES AND BIOLOGICAL ACTIVITIES OF SEVERAL NEWLY ISOLATED NATRIURETIC PEPTIDES (1991) (1)
- Design and Synthesis of Peptide Lead Drugs (1994) (1)
- The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain. (2004) (1)
- A new synthesis of (+)-negamycin and its derivatives as a potential therapeutic agent for Duchenne muscular dystrophy treatment. (2009) (1)
- Reverse Osmosis Separations of Aqueous NaCl–Organic Solute Systems (1985) (1)
- Editorial: Protease inhibitors (1999) (1)
- Structure-function relationships of the melanotropins. (1975) (1)
- Peptide Coupling Reagents : BOP and Congeners (1990) (1)
- Quantitative evaluation of refolding conditions for a disulfide‐bond‐containing protein using a concise 18O‐labeling technique (2011) (1)
- Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry (2004) (1)
- Effect of α-rat Atrial Natriuretic Polypeptide on Blood Pressure in Rats Bilateral Renal Vessels Ligated (1985) (1)
- Synthesis and in vivo evaluation of N-13 labeled opioid peptide analogue for PET opiate receptor studies (1989) (1)
- Fmoc‐based solid phase chemical synthesis of 71‐meric neuregulin 1‐β1, an epidermal growth factor‐like domain (2008) (1)
- [Development of HIV protease inhibitors as anti AIDS drugs: molecular design based on substrate transition state]. (1998) (1)
- Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography (2009) (1)
- The “ O -Acyl Isopeptide Method” for the Synthesis of Alzheimer’s Disease-Related Amyloid β Peptide (Aβ) 1–42 (2006) (1)
- Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs (2003) (1)
- Protease Inhibitors: Design and New Features (2003) (1)
- Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands (2005) (1)
- Application of intramolecular carbonate-carbamate migration (2006) (1)
- Tetrafluoroboric Acid as a Useful Deprotecting Reagent in Fmoc-Based Solid-Phase Peptide Syntheses (Fmoc = Fluoren-9-ylmethoxycarbonyl). (1990) (1)
- Evaluation of interaction between organic solutes and a membrane polymer by an inverse HPLC method (2014) (1)
- High Performance Aerobic Digestion of Organic Sludge using a Pilot-scale Mesh-filtration Bioreactor (2008) (1)
- Radioimmunoassay for Atrial Natriuretic Polypeptide (1985) (1)
- Click Peptides: Design and Applications (2008) (1)
- Statistical Distribution and Estimation Methods of 75% Probability of BOD in River Water. (1996) (1)
- [Kynostatin (KNI)-272--a rationally designed tripeptide inhibitor of HIV protease]. (1993) (1)
- Special issue : fifth Symposium on Biodilm Process Research.Removal function of pollutanto by an anaerobic - aerobic filter bed system and its numerical analysis. (1991) (1)
- Effect of α-human Atrial Natriuretic Polypeptide (α-hANP) on Canine Renal Na+-K+ ATPase Activity (1985) (1)
- SYNTHESIS AND ACTIVITY OF C-TERMINAL HEPTAPEPTIDES OF TACHYKININS AND BOMBESIN-LIKE PEPTIDES (1979) (1)
- Protease inhibitors (1999) (1)
- An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence (2003) (1)
- Studies on peptides. LIII. Synthesis of the docosapeptide corresponding to the entire amino acid sequence of porcine ACTH-like intermediate lobe peptide (CLIP). (1975) (1)
- “O, N-Acyl migration”-type prodrugs of dipeptide HIV protease inhibitors (2002) (1)
- Controlled Drug Release: New Water‐Soluble Prodrugs of an HIV Protease Inhibitor. (2001) (1)
- Synthesis of Di‐ and Tripeptide Analogues Containing α‐Ketoamide as a New Core Structure for Inhibition of HIV‐1 Protease. (2001) (1)
- Immuohistochemical demonstration of alpha-atrial natriretic plypeptide-containing neurons in the rat brain. (1985) (1)
- The Plasmepsin Family as Antimalarial Drug Targets (2011) (1)
- Efficient Synthesis of Peptaibol Using a Chloroimidazolidium Coupling Reagent, CIP. (1997) (1)
- Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry. (2009) (1)
- Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity (2004) (1)
- Inverse HPLC approach for the evaluation of repulsive interaction between ionic solutes and a membrane polymer (2015) (1)
- Paclitaxel Prodrugs: Toward Smarter Delivery of Anticancer Agents (2007) (1)
- Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin (2005) (1)
- Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors (2001) (1)
- Studies on peptides. CXXXVII. Conventional solution synthesis of porcine hypothalamic growth hormone releasing factor (pGRF). (1986) (1)
- A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62). (1991) (1)
- The Effects of Molecular Width of Organic Solute on Membrane Permeability (1993) (1)
- Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique (2011) (1)
- Performances of Aerobic Digestion and Biological Nitrogen Removal for Johkasou Raw Sludge (2008) (1)
- Acquisition of neutralizing antibody against mouse mitocryptide-2 and investigation of its physiological roles (2017) (0)
- Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide (2011) (0)
- Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines (2006) (0)
- Development of an O‐Acyl Isopeptide Method (2007) (0)
- Characterization of adsorbed materials on activated carbon and liquid phase regeneration. (1984) (0)
- Synthesis of a Novel Water-Soluble Paclitaxel Prodrug, Arginine-Isotaxel, and its Physicochemical and Caco-2 Transport Properties (2007) (0)
- Identification and Structure-Activity Studies of Novel Cryptides Hidden in Mitochondrial Proteins (2013) (0)
- An Expedient Synthesis of Nα-Protected-L-tetrahydrofuranylglycine and Its Application in the Synthesis of Novel Substrate Based Inhibitors of HIV-1 Protease. (2003) (0)
- Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents (2009) (0)
- Efficient Coupling of α,α‐Dimethyl Amino Acid Using a New Chloro Imidazolidium Reagent, CIP. (1994) (0)
- Synthesis of Novel Amino Acids, L‐Bis‐tetrahydrofuranylglycines. (2002) (0)
- Atrial Natriuretic Polypeptides in SHR and SHR Stroke-Prone (1985) (0)
- [Approval of HIV protease inhibitors as the AIDS therapeutics of next generation]. (1997) (0)
- Anchoring of Fmoc Amino Acid to 4-Alkoxybenzyl Alcohol Resin Using a New Esterification Reagent (I), (II). (2010) (0)
- Design and Synthesis of a Covalently Linked HIV-1 Protease Dimer Analogue and Peptidomimetic Inhibitors (2010) (0)
- Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation (2009) (0)
- Development of New Photoresponsive Paclitaxel Prodrug (2007) (0)
- A Novel Method for the Synthesis of Difficult Sequence-Containing Peptides via O-Acyl Isopeptides : The Use of O-N Intramolecular Acyl Migration Reaction (2004) (0)
- Structure-activity relationships of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic (1993) (0)
- [Discovery of cryptides and their novel signaling pathways]. (2010) (0)
- Studies on peptides. XL. Synthesis of the protected dodecapeptide corresponding to positions 1 to 12 of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (0)
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids (2006) (0)
- PEPTIDES. LVII. SYNTHESIS OF OCTADECAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF EQUINE β-MELANOCYTE-STIMULATING HORMONE (1976) (0)
- A new deprotecting procedure in peptide synthesis (1991) (0)
- Growth of high-quality and large crystals of HIV protease for neutron crystallography (2008) (0)
- Click peptide by use of the O-acyl isopeptide method: Production of Amyloid Beta peptide from water-soluble analogue (2009) (0)
- The promising anti-HIV agent kynostatin (KNI)-272: A highly selective and super-active HIV protease inhibitor containing allophenylnorstatine (1994) (0)
- Synthesis of O-Acyl Isopeptide by Use of Native Chemical Ligation to Efficiently Construct Hydrophobic Polypeptide (2012) (0)
- Studies on peptides. LVII. Synthesis of the octadecapeptide corresponding to the entire amino acid sequence of equine beta-melanocyte-stimulating hormone. (1975) (0)
- Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease (2002) (0)
- A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis (2009) (0)
- A process for the preparation of peptide derivatives and their salts (1993) (0)
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues (2006) (0)
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES (1987) (0)
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres (2006) (0)
- Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors (2011) (0)
- A New Stepwise Deprotection Method using Reductive Acidolysis Followed by Fluoride Ion in Solid Phase Peptide Synthesis. (1994) (0)
- The crystal structure of htlv protease complexed with the inhibitor KNI-10681 (2010) (0)
- Click Peptide: Water-Soluble Precursor Producing Monomer Amyloid β Peptide in Situ (2009) (0)
- Protease inhibitors (2007) (0)
- Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption (2003) (0)
- Surface Analysis of the Reverse Osmosis Membranes Used for Advanced Treatment of Human Excreta. (1994) (0)
- Enzyme Inhibitors, Aspartic Proteases (2019) (0)
- STUDIES ON PEPTIDES PART 39, N-ISOBUTOXYCARBONYL-2-ALKOXY-1,2-DIHYDROQUINOLINE DERIVATIVES, AS COUPLING REAGENTS IN PEPTIDE SYNTHESIS (1974) (0)
- 3-18 Characterization of bacteria isolated from an acidophilic nitrification reactor(Waste water treatment ecosystem,Oral presentation) (2007) (0)
- INHIBITEUR DE LA β-SECRÉTASE (2006) (0)
- Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors (2003) (0)
- Ligand recognition mechanisms of formyl peptide receptor 2 (2017) (0)
- General Report on the 42^ Annual Conference of JSWE (2008) (0)
- Syntheses and structure-activity relationships of natriuretic peptides (1993) (0)
- Synthesis of biotin-tagged diketopiperazine-based anti-microtubule agents and tubulin photoaffinity labeling. (2009) (0)
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability (2005) (0)
- Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease (2012) (0)
- Kynostatin (KNI)‐227 and ‐272, Highly Potent Anti‐HIV Agents: Conformationally Constrained Tripeptide Inhibitors of HIV Protease Containing Allophenylnorstatine. (1993) (0)
- Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization (2009) (0)
- Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine (2006) (0)
- A Convenient Synthetic Method for Monodehydro-2,5-diketopiperazines (2006) (0)
- Intact Cell-based SPR Analyses of Interactions between EGF and its Receptor (2011) (0)
- STUDIES ON PEPTIDES PART 35, SOME P‐METHOXYBENZYLOXYCARBONYL‐AMINO ACID DERIVATIVES (1973) (0)
- The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) (2003) (0)
- Efficient Synthesis of Alamethicin using a Newly Developed Coupling Reagent, CIP (1995) (0)
- Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells (2007) (0)
- Effects of DOCA and Salt Overloading on the Content of α-Rat Atrial Natriuretic Polypeptide-like Immunoreactivity in Rat Atrium (1985) (0)
- P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION (2006) (0)
- P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT" (2006) (0)
- Investigation of Signaling Mechanisms Induced by Mitocryptides in Neutrophilic/granulocytic Cells (2008) (0)
- Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors (2006) (0)
- Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel Beta-Sheet Structure Formed by Abeta on GM1 Clusters (2019) (0)
- The synthesis of bioactive peptides based on O-Acyl Isopeptide Method: Application of O-acyl isodipeptide units (2007) (0)
- Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides (2011) (0)
- Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes (2007) (0)
- “MINIMAL SEGMENT” OF ENKEPHALIN FOR ANALGESIA: SYNDYPHALIN (SD)-33, A SIMPLE TRIPEPTIDE ALKYLAMIDE WITH PROLONGED SUBCUTANEOUS ANALGESIC ACTIVITY (1981) (0)
- KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic (1998) (0)
- New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor (2000) (0)
- Solution-phase synthesis of alpha-rat atrial natriuretic peptide (alpha-rANP). (1990) (0)
- Tetrafluoroboric Acid, a Useful Deprotecting Reagent in Peptide Synthesis.AB: (1990) (0)
- A New Class of Amino Protecting Group Removable by Reductive Acidolysis: The 4-Methylsulfinylbenzyloxycarbonyl (Msz) Group. (1990) (0)
- A Novel Dipeptide-Based HIV Protease Inhibitor Containing Allophenylnorstatine. (2005) (0)
- crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor (2010) (0)
- Role of pro-region in secretion of Escherichia coli heat-stable enterotoxin STp: (2009) (0)
- Atrial Natriuretic Polypeptides in Rat Heart and Plasma (1985) (0)
- O—N Intramolecular Acyl Migration Strategy in Water-Soluble Prodrugs of Taxoids. (2004) (0)
- Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues (2011) (0)
- Bioactive Peptides and Drug Discovery (2020) (0)
- A Simple Diastereoselective Synthesis of Cyclohexylnorstatine and Allocyclohexylnorstatine. (1990) (0)
- Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy (2011) (0)
- SYNTHESES AND OPIOID ACTIVITIES OF ENKEPHALIN-AND DERMORPHIN-RELATED PEPTIDES (1984) (0)
- Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide (2011) (0)
- SYNTHESIS AND ANALGESIC ACTIVITY OF NEO-KYOTORPHIN ANALOGS (1985) (0)
- Crystal Structure of HIV-1 Protease Complexed with KNI-1689 (2010) (0)
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES (1990) (0)
- SYNTHESES AND STRUCTURE-ACTIVITIES RELATIONSHIPS OF SMALLSIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES WITH POTENT ACTIVITY (1992) (0)
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants (2006) (0)
- Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers (1995) (0)
- Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure (2011) (0)
- PEPTIDES. LIII. SYNTHESIS OF THE DOCOSAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF PORCINE ACTH-LIKE INTERMEDIATE LOBE PEPTIDE (CLIP) (1976) (0)
- Design and Synthesis of an Orally Potent Human Renin Inhibitor (R,S,S,R)-(I) Containing a Novel Amino Acid, Cyclohexylnorstatine (2R,3S)-(II). (1990) (0)
- Derives peptidiques a activite inhibitrice de la $g(b)secretase (2004) (0)
- SYNTHESIS AND ACTIVITY OF A NEWLY ISOLATED ANALGESIC PENTAPEPTIDE, NEO-KYOTORPHIN (1983) (0)
- Developments in peptide synthesis and peptidomimetic chemistry: HIV protease analogs and substrate-based inhibitors (1999) (0)
- Novel Neutrophil-Activating Cryptides Hidden in Mitochondrial Cytochrome c : Identification and Structure-Activity Studies (2012) (0)
- Synthesis of Human Endothelin‐1 by Regioselective Disulfide Formation Using the Silyl Chloride‐Sulfoxide System. (1995) (0)
- NIM-P-METHOXYPHENYLSULFONYLHISTIDINE, A NEW DERIVATIVE FOR PEPTIDE SYNTHESIS (1980) (0)
- Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy (2008) (0)
- Evans’ Asymmetric Alkylation on Solid Supports (2005) (0)
- A novel approach for the hydrophobic peptides synthesis and purification through O-N intramolecular acyl migration reaction (2004) (0)
- Solution-phase synthesis of α-human atrial natriuretic peptide (α-hANP) (1990) (0)
- Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer (2008) (0)
- Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value? (2011) (0)
- Phenylahistin, a Small Dipeptidic Colchicine-Like Anti-Microtubule Agent: Total Synthesis and SAR Study of the Derivatives (2001) (0)
- "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42 (2005) (0)
- Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions (2005) (0)
- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs (1996) (0)
- "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues (2007) (0)
- Synthesis of polylactides with side chain functionality: ring-opening polymerimerization of a homobislactone prepared from lysine. (2009) (0)
- STUDIES ON PEPTIDES PART 44, SYNTHESIS OF THE BASIC TRYPSIN INHIBITOR FROM BOVINE PANCREAS (KUNITZ AND NORTHROP) BY THE FRAGMENT CONDENSATION PROCEDURE ON POLYMER SUPPORT (1974) (0)
- Investigation of signaling mechanisms induced by mitocryptide-3, a novel neutrophil-activating peptide derived from a mitochondrial transit sequence (2017) (0)
- Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt (2002) (0)
- Prodrug Forms of Peptidomimetic HIV Protease Inhibitors Using Intramolecular Cyclization Reaction (2001) (0)
- Efficient solid phase peptide synthesis. Use of methanesulfonic acid alpha-amino deprotecting procedure and new coupling reagent, 2-(benzotriazol-1-yl)oxy-1,3-dimethylimidazolidinium hexafluorophosphate (BOI). (1993) (0)
- Removal of Trace Organic Pollutants by Membrane Filtration (2002) (0)
- Growth of large protein crystals for neutron crystallography by hanging a seed crystal (2008) (0)
- Studies on peptides. CXXXVIII. Conventional solution synthesis of bovine hypothalamic growth hormone releasing factor (bGRF). (1986) (0)
- Synthesis of an HIV-1 protease dimer analog covalently linked by a disulfide bridge (1999) (0)
- Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept (1992) (0)
- Disulfide bond formation in peptides by silylchloride-sulfoxide: Scope and applications (1993) (0)
- ILVIII-9 DEFYING DIFFICULT DISEASES : DESIGN OF PROTEASE INHIBITORS AND PRODRUG FORMS(Drug Discovery and Developments) (2006) (0)
- Nin-Diphenylphosphinothioyltryptophan, a Useful Derivative for Peptide Synthesis by the Methanesulfonic Acid - Thioanisole System and Fluoride Ion Deprotection Methods. (1988) (0)
- Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption (2007) (0)
- Structure activity relationships of mitocryptide-3 for the elucidation of ligand recognition mechanisms of its receptors (2017) (0)
- Medicinal Science Studies Based on Synthetic Peptide Chemistry (2004) (0)
- O—N Intramolecular Alkoxycarbonyl Migration of Typical Protective Groups in Hydroxyamino Acids. (2006) (0)
- Human T-cell Leukemia Virus Type I (HTLV-I) Retropepsin (2013) (0)
- High-throughput Screening Method for Ligand Peptides Using Capillary Electrophoresis-Mass Spectrometry (CE-MS) (2009) (0)
- Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657 (2018) (0)
- Evaluation of Malarial Protease Plasmepsin Inhibitors Containing Hydroxymethylcarbonyl Isostere (2006) (0)
- O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids (2005) (0)
- Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties (2008) (0)
- P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING (2006) (0)
- Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 (2003) (0)
- STUDIES ON PEPTIDES PART 50, ACIDOLYSIS OF PROTECTING GROUPS IN PEPTIDE CHEMISTRY BY FLUOROSULPHONIC ACID AND METHANESULPHONIC ACID (1975) (0)
- A Practical Synthesis of an Orally Potent Renin Inhibitor, Isopropyl (2R,3S)-4-Cyclohexyl-2-hydroxy-3-(N-((2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl)-L-histidyl)aminobutyrate (1990) (0)
- New disulfide bond-forming reactions for peptide and protein synthesis. (1994) (0)
- Syntheses of Natriuretic Peptides Using a New S -Protecting Group, S -Trimethylacetamidomethyl (Tacm) Group (1994) (0)
- Effects of α-human atrial natriuretic polypeptide on vascular strips and perfused mesenteric vessels of SHR and WKY (1985) (0)
- Quantitative Analyses of Disulfide Bond Formation in Proteins Using ^ O-Labeled Peptide Standards (2012) (0)
- Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic (2004) (0)
- Functional Analysis of Mitocryptides with Their Monoclonal Antibodies (2013) (0)
- Two new reagents for the coupling of sterically hindered amino acids (1993) (0)
- Design of HIV protease inhibitors with effective antiviral activity: Use of allophenylnorstatine as a transition-state mimic (1993) (0)
- Structure—Activity Relationship Studies of Chloromethyl Ketone Derivatives for Selective Human Chymase Inhibitors. (2010) (0)
- Synthesis of Cystine‐Peptide by a New Disulfide Bond‐Forming Reaction Using the Silyl Chloride‐Sulfoxide System. (1991) (0)
- Chemical Synthesis of 71-meric Neuregulin 1-β1 (2009) (0)
- Small-sized HIV protease inhibitors containing allophenyinorstatine exhibit antiviral activities (1996) (0)
- Efficient Total Synthesis of (+)-Negamycin and Its Derivatives (2009) (0)
- Nouveaux composes de tripeptides et medicaments anti-sida (1997) (0)
- Small Peptide-based Medicinal Chemistry for Intractable Disease (2009) (0)
- Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker (1996) (0)
- THE EFFECTS OF SALT ADDITION ON FOULING IN REVERSE OSMOSIS (1983) (0)
- CIP and CIB: Two new reagents for the esterification or difficult coupling of sterically hindered amino acids (1993) (0)
- Design and Synthesis of β-Secretase Inhibitors: Optimization at the P4 and P1′ Positions (2006) (0)
- Solution NMR Studies of the HIV-1 Protease/Inhibitor Complex : The HIV-1 Protease Catalytic Aspartyl Side-Chain Carboxyl Groups Have Distinct Protonation States in the Complex Formed with the Asymmetric Inhibitor KNI-272 (1996) (0)
- Oxamide Replacement in Pseudo-Symmetric HIV Protease Inhibitor Involving Multiple Bridging Water Molecules (2013) (0)
- SYNTHESES OF CYSTINE-PEPTIDES BY A NEW DISULPHIDE BOND FORMING REACTION (1992) (0)
- Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide (2008) (0)
- Cryptides : Non-Classical Bioactive Peptides Hidden in Protein Structures (2011) (0)
- Defying Difficult Diseases : Peptide Chemistry in Medicinal Science (2009) (0)
- A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide (2009) (0)
- [Structural analysis of protease-inhibitor system using graphics]. (1997) (0)
- Design and SAR Study of Tripeptidic BACE1 Inhibitors (2012) (0)
- Neuronal opiate receptors in rabbit ear artery. (1983) (0)
- Click Peptide : In Situ Production of pyroGlu-Abeta from the O-Acyl Isopeptide (2011) (0)
- An efficient synthesis of tryptophan-containing cystine peptide using the silyl chloride-sulfoxide system (1999) (0)
- Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II (2007) (0)
- STUDIES ON PEPTIDES. LXVII. SYNTHESIS OF THE HEXADECAPEPTIDE CORRESPONDING TO O POSITION 1 THROUGH 16 OF PORCINE CHOLECYSTOKININ-PANCREOZYMIN (CCK-PZ) (1977) (0)
- Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin (2009) (0)
- Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety (2007) (0)
- Mitocryptide-3: physiological significance of a novel neutrophil-activating peptide derived from a mitochondrial transit signal sequence (2017) (0)
- Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic (1995) (0)
- STUDIES ON PEPTIDES PART 43, SYNTHESIS OF TWO PROTECTED PEPTIDES RELATED TO THE C-TERMINAL PORTION OF THE BASIC TRYPSIN INHIBITOR FROM BOVINE PANCREAS (KUNITZ AND NORTHROP) (1974) (0)
- Sludge Reduction Performance of Aerobic Digestion Reactors for Johkasou System (2007) (0)
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support (2008) (0)
- Fmoc-Based Solid-Phase Peptide Synthesis Using a New t-Alcohol Type 4-(1′,1′-Dimethyl-1′-hydroxypropyl)phenoxyacetyl Handle (DHPP)-Resin (Fmoc = Fluoren-9-ylmethoxycarbonyl). (1990) (0)
- Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method (1998) (0)
- Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075 (2007) (0)
- Controlled Drug Release : Design and Application of New Water-soluble Prodrugs (2002) (0)
- [Trends and problems in the development of neuropeptide drugs]. (1990) (0)
- Nitrogen Removal Performance in Biological Decomposition on N, N-Dimethylformamide under Acidic Conditions (2009) (0)
- The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) (2003) (0)
- Cryptide Signaling and the Exocytotic Mechanisms Induced by Amphiphilic Peptides (2009) (0)
- Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment (2011) (0)
- Design of Double-Drug-Type Anti-HIV Agents (2001) (0)
- Effect of Synthetic Atrial Natriuretic Polypeptide on Diuresis, Natriuresis and Blood Pressure in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY) (1985) (0)
- Trimethylacetamidomethyl (Tacm) Group, a New Protecting Group for the Thiol Function of Cysteine. (1990) (0)
- Structure-Migration Rate Relationship of Water-Soluble Prodrugs of HIV-1 Protease Inhibitors Based on O→N Intramolecular Acyl Migration (2003) (0)
- Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design (2011) (0)
- Design and Synthesis of Substrate-Based Peptidomimetic Human Immunodeficiency Virus Protease Inhibitors Containing the Hydroxymethylcarbonyl Isostere (1996) (0)
- Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog (2007) (0)
- Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit" (2007) (0)
- Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction (2006) (0)
- Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 (2003) (0)
- Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors (2011) (0)
- NMR Studies on Reorientation Process of the Inhibitor Tightly Bound to HIV Protease (2000) (0)
- Design of HIV protease inhibitors based on the transition state concept (1993) (0)
- Studies on peptides. XLI. Synthesis of the protected hexadecapeptide corresponding to positions 13 to 28 of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (0)
- Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleava (1991) (0)
- Ring Size and Side-Chain Orientation of Inhibitory Cyclic Peptides against EGF Receptor Dimerization (2013) (0)
- Structure-activity relationships of HIV protease inhibitors containing hydroxymethylcarbonyl isostere as a transition state mimic (1993) (0)
- SAR study of BACE1 inhibitors containing pyridine derivatives (2009) (0)
- Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10033 (2007) (0)
- Design and activity of protease active site-targeted anti-HIV agents containing allophenylnorstatine (1993) (0)
- Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor (1998) (0)
- Kynostatins, highly selective and superpotent HIV protease inhibitors: Conformationally constrained tripeptides containing allophenylnorstatine as a transition-state mimic (1995) (0)
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety (2007) (0)
- Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent (2011) (0)
- 2Hp13 Characterization of predominant uncultured bacteria affiliated with the candidate phylum TM7 in an acidophilic nitrifying reactor (2009) (0)
- Efficient Coupling of Dialky Amino Acid Using a Chloro Imidazolidium Reagent, CIP (1995) (0)
- Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere (2006) (0)
- Fluoren‐9‐ylmethyloxycarbonyl (Fmoc) Amino Acid Chloride as an Efficient Reagent for Anchoring Fmoc Amino Acid to 4‐Alkoxybenzyl Alcohol Resin. (2010) (0)
- Isotope Labeling-assisted Quantitative Evaluation of Refolding Conditions of a Recombinant Disulfide Protein (2011) (0)
- New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling (2007) (0)
- Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine (2001) (0)
- Single substitution of n‐terminal amino acid in 111In‐DTPA‐octreotide significantly affects renal accumulation (2001) (0)
- Potent dipeptide HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimetic (2002) (0)
- Organic Chemistry and Medicinal Chemistry Based on α‐Hydroxy‐β‐Amino Acids (2005) (0)
- SOLVENT EFFECTS ON STEREO AND REGIOSELECTIVITIES OF THE RING‐OPENING REACTION OF EPOXIDE WITH ALUMINUM CHLORIDE (1976) (0)
- Candida albicans secreted aspartic peptidase specificity A chromogenic combinatorial approach (2003) (0)
- Synthesis of HIV-1 protease analog by ligation of bromoacetyl and mercaptoethylamide peptide prepared using disulfide linkage to solid-support (2002) (0)
- Renin inhibitors designed on the basis of angiotensinogen transition state (1989) (0)
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What Schools Are Affiliated With Yoshiaki Kiso?
Yoshiaki Kiso is affiliated with the following schools: