Yoshiaki Kiso

Q: What Schools Are Affiliated With Yoshiaki Kiso

Yoshiaki Kiso is affiliated with the following schools: Kyoto Pharmaceutical University, Kobe Gakuin University, Toyohashi University of Technology, Nagahama Institute of Bio-Science and Technology, University of Tokyo, Institute of Science Tokyo, Kyoto University

Yoshiaki Kiso's AcademicInfluence.com Rankings

Yoshiaki Kiso

Computer Science

#6683

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#7043

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Computational Linguistics

#1205

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#1219

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Machine Learning

#2250

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#2278

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Artificial Intelligence

#2516

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#2557

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computer-science Degrees

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Computer Science

Yoshiaki Kiso's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Yoshiaki Kiso's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. (1990) (332)
Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes (2001) (274)
Atrial natriuretic polypeptide: Topographical distribution in the rat brain by radioimmunoassay and immunohistochemistry (1985) (265)
Alpha-human atrial natriuretic polypeptide is released from the heart and circulates in the body. (1985) (226)
Phosphate removal and recovery with a synthetic hydrotalcite as an adsorbent. (2006) (222)
NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent (2006) (217)
Rejection properties of non-phenylic pesticides with nanofiltration membranes (2000) (215)
Occurrence of atrial natriuretic polypeptide in brain. (1985) (184)
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model (2006) (174)
Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization (2007) (169)
Rejection properties of alkyl phthalates with nanofiltration membranes (2001) (161)
Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides. (2004) (155)
The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design. (2001) (148)
Paclitaxel prodrugs: toward smarter delivery of anticancer agents. (2006) (147)
Wastewater treatment performance of a filtration bio-reactor equipped with a mesh as a filter material (2000) (138)
Radioimmunoassay for α-human and rat atrial natriuretic polypeptide (1984) (134)
The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice (2006) (133)
Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272. (1996) (133)
Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine. (1992) (122)
Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine. (1995) (117)
Analysis of pesticides in environmental water samples by solid-phase micro-extraction-high-performance liquid chromatography. (1996) (115)
Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography (2009) (112)
Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective (2006) (112)
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor. (2003) (98)
click peptide based on the O-acyl isopeptide method : Control of Aβ1 42 production from a photo-triggered Aβ1 42 analogue (2006) (94)
Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor (2000) (91)
Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. (1998) (89)
Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability. (2005) (89)
Effect of molecular charges on renal uptake of 111In-DTPA-conjugated peptides. (2001) (89)
Synthesis of Palmitoyl Derivatives of Insulin and Their Biological Activities (1989) (85)
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction. (1990) (80)
Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method (1993) (78)
Fiber-in-tube solid-phase microextraction: a fibrous rigid-rod heterocyclic polymer as the extraction medium (2000) (77)
A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel. (2003) (75)
KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. (1991) (75)
KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides. (2003) (75)
Rejection properties of pesticides with a hollow fiber NF membrane (HNF-1) (2002) (74)
The ‘O‐acyl isopeptide method’ for the synthesis of difficult sequence‐containing peptides: application to the synthesis of Alzheimer's disease‐related amyloid β peptide (Aβ) 1–42 (2005) (74)
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure. (2012) (73)
Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. (2002) (72)
Design and synthesis of a novel water-soluble Aβ1-42 isopeptide: an efficient strategy for the preparation of Alzheimer's disease-related peptide, Aβ1-42, via O–N intramolecular acyl migration reaction (2004) (72)
Development of O-acyl isopeptide method. (2007) (70)
Avidin-biotin affinity columns. General methods for attaching biotin to peptides and proteins (1978) (69)
Miniaturized solid-phase extraction as a sample preparation technique for the determination of phthalates in water (2002) (67)
ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence‐containing bioactive peptides (2004) (66)
Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases (2008) (65)
Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins (1994) (63)
Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs. (2008) (63)
Coupling of sequencing batch reactor and mesh filtration: operational parameters and wastewater treatment performance. (2005) (62)
Effect of molecular shape on rejection of uncharged organic compounds by nanofiltration membranes and on calculated pore radii (2010) (62)
KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. (2004) (62)
Total synthesis of anti-microtubule diketopiperazine derivatives: phenylahistin and aurantiamine. (2000) (60)
Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. (1999) (60)
“Click Peptides”—Chemical Biology‐Oriented Synthesis of Alzheimer's Disease‐Related Amyloid β Peptide (Aβ) Analogues Based on the “O‐Acyl Isopeptide Method” (2006) (60)
Efficient removal of N-benzyloxycarbonyl group by a ‘push–pull’ mechanism using thioanisole–trifluoroacetic acid, exemplified by a synthesis of Met-enkephalin (1980) (59)
Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres. (2006) (59)
Disulfide Bond Formation Using the Silyl Chloride-Sulfoxide System for the Synthesis of a Cystine Peptide (1992) (58)
The effects of molecular width on permeation of organic solute through cellulose acetate reverse osmosis membranes (1992) (58)
Pore radius estimation based on organic solute molecular shape and effects of pressure on pore radiu (2011) (57)
Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere. (1996) (57)
“Click Peptide“: pH‐Triggered in Situ Production and Aggregation of Monomer Aβ1–42 (2009) (56)
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV‐1 protease (2004) (55)
Development of first photoresponsive prodrug of paclitaxel. (2006) (55)
‘O-Acyl isopeptide method’ for the efficient synthesis of difficult sequence-containing peptides: use of ‘O-acyl isodipeptide unit’ (2006) (54)
Efficient coupling of α,α-dimethyl amino acid using a new chloro imidazolidium reagent, CIP (1994) (53)
Significance of α‐Human Atrial Natriuretic Polypeptide as a Hormone in Humans (1986) (52)
Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements (1980) (52)
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. (2006) (52)
Wastewater treatment performance and sludge reduction properties of a household wastewater treatment system combined with an aerobic sludge digestion unit (2008) (51)
Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo. (1998) (50)
Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. (2009) (50)
New human renin inhibitors containing an unnatural amino acid, norstatine. (1988) (50)
Recent progress in the drug discovery of non-peptidic BACE1 inhibitors (2009) (50)
beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells. (2006) (49)
Factors affecting adsorption of organic solutes on cellulose acetate in an aqueous solution system (1986) (49)
How Much Binding Affinity Can be Gained by Filling a Cavity? (2010) (49)
Isolation of a novel analgesic pentapeptide, neo-kyotorphin, from bovine brain. (1982) (49)
Synthesis of di- and tripeptide analogues containing alpha-ketoamide as a new core structure for inhibition of HIV-1 protease. (2000) (48)
Existence of atrial natriuretic polypeptide in kidney. (1985) (48)
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety (2012) (47)
Application of the O-N intramolecular acyl migration reaction in medicinal chemistry. (2007) (47)
Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro (2008) (45)
Atrial natriuretic peptide antagonists: biological evaluation and structural correlations. (1990) (44)
Bound Water Molecules at the Interface between the HIV-1 Protease and a Potent Inhibitor, KNI-272, Determined by NMR (1996) (43)
Novel non-peptidic and small-sized BACE1 inhibitors. (2008) (43)
New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration. (2002) (42)
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. (2006) (42)
Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic. (1999) (41)
Flexibility and Function in HIV Protease: Dynamics of the HIV-1 Protease Bound to the Asymmetric Inhibitor Kynostatin 272 (KNI-272) (1998) (41)
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors (2009) (41)
HIV protease inhibitors: peptidomimetic drugs and future perspectives. (2002) (40)
Search for substrate‐based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II (2004) (39)
Specific binding activities and cyclic GMP responses by atrial natriuretic polypeptide in kidney epithelial cell line (LLC-PK1). (1985) (39)
Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere. (2000) (39)
Convergent Synthesis of (−)-Mirabazole C Using a Chloroimidazolidium Coupling Reagent, CIP (1996) (38)
Acidogenic fermentation of blended food‐waste in combination with primary sludge for the production of volatile fatty acids (2005) (38)
Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin. (1994) (38)
Solventless sample preparation procedure for organophosphorus pesticides analysis using solid phase microextraction and on-line supercritical fluid extraction/high performance liquid chromatography technique (2001) (37)
Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum. (2011) (37)
"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH. (2007) (37)
Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study (2013) (37)
The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors (2012) (37)
No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions. (2005) (36)
Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage. (2003) (36)
[An approach to the targeted attachment of peptides and proteins to solid supports]. (1976) (36)
Small-sized BACE1 inhibitors (2006) (36)
Anchoring of Fmoc amino acid to 4-alkoxybenzyl alcohol resin using a new esterification reagent (1992) (36)
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents. (2012) (36)
BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety. (2008) (35)
Liquid chromatography in a capillary packed with fibrous cellulose acetate (1986) (34)
Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study. (2004) (34)
Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors (2006) (34)
Studies on peptides. L. Acidolysis of protecting groups in peptide chemistry by fluorosulphonic acid and methanesulphonic acid. (1975) (34)
Conventional and high-yield synthesis of DTPA-conjugated peptides: application of a monoreactive DTPA to DTPA-D-Phe1-octreotide synthesis. (1997) (34)
Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases (2004) (34)
Controlled Production of Amyloid β Peptide from a Photo‐Triggered, Water‐Soluble Precursor “Click Peptide“ (2008) (34)
Macrocyclization on solid support using Heck reaction (1997) (33)
'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants. (2005) (32)
Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer's disease: progress and problems. (2006) (32)
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV. (2008) (32)
Cellulose acetate as stationary phase in microcolumn LC (1989) (32)
'O-Acyl isopeptide method' : racemization-free segment condensation in solid phase peptide synthesis (2006) (32)
Excess sludge reduction performance of an aerobic SBR process equipped with a submerged mesh filter unit (2006) (31)
Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold. (2009) (31)
Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats (2000) (31)
Bacteria of the Candidate Phylum TM7 are Prevalent in Acidophilic Nitrifying Sequencing-Batch Reactors (2014) (31)
Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor. (2001) (31)
Advances in the identification of β-secretase inhibitors (2013) (30)
Pesticide analysis by high-performance liquid chromatography using the direct injection method (1996) (30)
O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids. (2003) (30)
Cellulose Acetate Fiber as Stationary Phase in Capillary Electrochromatography (1998) (29)
‘O‐Acyl isopeptide method’ for peptide synthesis: Solvent effects in the synthesis of Aβ1–42 isopeptide using ‘O‐acyl isodipeptide unit’ (2007) (29)
Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin. (2010) (29)
‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues (2006) (29)
Rejection properties of aromatic pesticides with a hollow-fiber NF membrane (2005) (28)
Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine (1989) (28)
Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions. (2010) (28)
KNI‐577, a Potent Small‐Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition‐State Mimic (1998) (28)
Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers. (2001) (27)
'Double-Drugs'--a new class of prodrug form of an HIV protease inhibitor conjugated with a reverse transcriptase inhibitor by a spontaneously cleavable linker. (2000) (26)
New directions for protease inhibitors directed drug discovery (2016) (26)
CONVERGENT SYNTHESIS OF DOLASTATIN 15 BY SOLID PHASE COUPLING OF AN N-METHYLAMINO ACID (1998) (26)
Chemical cleaning of reverse osmosis membranes used for treating wastewater from a rolling mill process (2006) (26)
Immunohistochemical demonstration of α-atrial natriuretic polypeptide-containing neurons in the rat brain (2004) (25)
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. (2008) (25)
Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions (2005) (25)
Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic. (2004) (25)
Deprotection of O-methyltyrosine by a ‘push–pull’ mechanism using the thioanisole–trifluoromethanesulphonic acid system. Application to the convenient synthesis of a potent N-methylenkephalin derivative (1979) (25)
Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties. (2007) (25)
Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor. (2003) (25)
O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids. (2006) (24)
Studies on Peptides, XXXIX. N-Isobutoxycarbonyl-2-alkoxy-1, 2-dihydroquinoline Derivatives, as Coupling Reagents in Peptide Synthesis (1973) (24)
Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates. (2001) (24)
Removal properties of arsenic compounds with synthetic hydrotalcite compounds (2005) (24)
Rejection properties of NF membranes for alkylphenols (2007) (24)
Fibrous stationary phase in capillary electrochromatography. (2001) (23)
Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters. (2018) (23)
Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease. (2010) (23)
2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline as a coupling reagent in peptide synthesis (1972) (23)
Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1. (2011) (23)
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. (2008) (23)
Novel Dextranase Catalyzing Cycloisomaltooligosaccharide Formation and Identification of Catalytic Amino Acids and Their Functions Using Chemical Rescue Approach* (2012) (23)
Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design. (2012) (22)
Synthesis of cystine-peptide by a new disulphide bond-forming reaction using the siiyl chloride–sulphoxide system (1991) (22)
Efficient synthesis of peptaibol using a chloroimidazolidium coupling reagent, CIP (1997) (22)
Discovery of Mitocryptide-1, a Neutrophil-activating Cryptide from Healthy Porcine Heart* (2008) (22)
Retention characteristics of aliphatic compounds on cellulose acetates as a stationary phase with an aqueous mobile phase (1989) (22)
Determination of Bisphenol A in Water Using a Packed Needle Extraction Device (2009) (21)
Trials of lipid modification of peptide hormones for intestinal delivery (1992) (21)
Bestatin potentiates the antinociception but not the motor dysfunction induced by intracerebrally administered dynorphin-B in mice (1989) (21)
An ‘active ester’-type mixed anhydride method for peptide synthesis. Use of the new reagent, norborn-5-ene-2,3-dicarboximido diphenyl phosphate (NDPP) (1980) (21)
BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor? (2012) (21)
Visual determination of nitrite and nitrate in waters by color band formation method. (2006) (21)
Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological Activity (1991) (20)
Deprotection of the S-trimethylacetamidomethyl (Tacm) group using silver tetrafluoroborate: application to the synthesis of porcine brain natriuretic peptide-32 (pBNP-32). (1990) (20)
A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions (2004) (20)
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. (2007) (20)
Regioselective double disulfide formation using silylchloride-sulfoxide system (1992) (20)
Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors. (2011) (19)
The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active. (2014) (19)
Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents (2008) (19)
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole. (2011) (19)
Convergent synthesis of (−)-mirabazole B using a chloroimidazolidium coupling reagent, CIP (1997) (19)
Fmoc-based solid-phase peptide synthesis using a new t-alcohol type 4-(1′,1′-dimethyl-1′-hydroxypropyl)phenoxyacetyl handle (DHPP)–resin (Fmoc = fluoren-9-ylmethoxycarbonyl) (1990) (19)
Adsorption properties of cyclic compounds on cellulose acetate (1999) (19)
Analysis of Amide Bond Formation with an α-Hydroxy-β-amino Acid Derivative, 3-Amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone (2001) (18)
Accelerated natriuresis induced by synthetic atrial natriuretic polypeptide in spontaneously hypertensive rats. (1985) (18)
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket. (2009) (18)
Studies on Peptides. XXX. Trichloroethyloxycarbonylhydrazine (1971) (18)
Sludge thickening performance of mesh filtration process. (2004) (18)
Total synthesis of (+)-negamycin and its 5-epi-derivative (2010) (18)
Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation. (2009) (17)
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position. (2012) (17)
Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor. (2012) (17)
Inhibition by KMI‐574 leads to dislocalization of BACE1 from lipid rafts (2009) (17)
Mitocryptide-2: Purification, Identification, and Characterization of a Novel Cryptide That Activates Neutrophils 1 (2009) (17)
Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases. (2008) (17)
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. (2010) (17)
Significance of (111)In-DTPA chelate in renal radioactivity levels of (111)In-DTPA-conjugated peptides. (2001) (17)
A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE (1989) (17)
Studies on peptides. XLIV. Synthesis of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) by the fragment condensation procedure on polymer support. (1974) (17)
Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (1999) (17)
Tripeptides acting on opioid receptors in rat colon. (1984) (17)
Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide (1983) (17)
Total synthesis of thiangazole (1999) (17)
Isopeptide method: development of S‐acyl isopeptide method for the synthesis of difficult sequence‐containing peptides (2008) (17)
Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor. (2001) (17)
Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. (2000) (17)
Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme. (2008) (17)
O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation. (2009) (16)
Switching from the unfolded to the folded state of the helix‐loop‐helix domain of the Id proteins based on the O‐acyl isopeptide method (2008) (16)
A new reductive acidolysis final deprotection strategy in solid phase peptide synthesis. Use of a new safety-catch linker (1994) (16)
Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors. (2007) (16)
EFFICIENT SOLID PHASE PEPTIDE SYNTHESIS ON A PHENACYL-RESIN BY A METHANESULFONIC ACID α-AMINO DEPROTECTING PROCEDURE (1990) (16)
Novel β-amyloid aggregation inhibitors possessing a turn mimic. (2015) (16)
Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element (2011) (15)
Comparison of a new orally potent tripeptide HIV‐1 protease inhibitor (anti‐aids drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations (1993) (15)
Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine (1978) (15)
Efficient deprotection of NG-tosylarginine with a thioanisole–trifluoromethanesulphonic acid system (1980) (15)
DESIGN AND SYNTHESIS OF A COVALENTLY LINKED HIV-1 PROTEASE DIMER ANALOG AND PEPTIDOMIMETIC INHIBITORS (1998) (15)
Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides (2009) (15)
Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: determined by NMR spectroscopy and simulated annealing calculations. (1996) (15)
Synthesis of the heptadecapeptide corresponding to the entire amino acid sequence of salmon melanin-concentrating hormone (MCH). (1984) (15)
Tetrafluoroboric acid as a useful deprotecting reagent in Fmoc-based solid-phase peptide syntheses (Fmoc = fluoren-9-ylmethoxycarbonyl) (1990) (15)
Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C. (2012) (15)
A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor. (1999) (15)
Syndyphalin SD‐25: a higly selective ligand for μ opiate receptors (1982) (15)
Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum. (2011) (15)
Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor. (2012) (15)
A new class of amino protecting group removable by reductive acidolysis: the 4-methylsulphinylbenzyloxycarbonyl (Msz) group (1989) (15)
Synthesis of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) by fragment condensation on a polymer support (1974) (14)
Pharmacokinetic study of a tripeptide HIV‐1 protease inhibitor, KNI‐174, in rats after intravenous and intraduodenal administrations (1993) (14)
Adsorption properties of aromatic compounds on polyethylene as a membrane material (1999) (14)
Morphine‐like activities of synthetic enkephalin analogues (1981) (14)
Fluoren-9-ylmethyloxycarbonyl (Fmoc) amino acid chloride as an efficient reagent for anchoring Fmoc amino acid to 4-alkoxybenzyl alcohol resin. (1990) (14)
Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties. (2008) (14)
A spot test for aqueous phosphate by color band formation (2002) (14)
Synthesis of porcine brain natriuretic peptide-32 using silver tetrafluoroborate as a new deprotecting reagent of the S-trimethylacetamidomethyl group. (1990) (14)
Solution structure of HIV-1 protease-allophenylnorstatine derivative inhibitor complex obtained from molecular dynamics simulation. (1994) (14)
A new thiol protecting trimethylacetamidomethyl group. Synthesis of a new porcine brain natriuretic peptide using the S-trimethylacetamidomethyl-cysteine (1989) (14)
Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy. (2012) (13)
Synthesis and activity of C-terminal heptapeptides of tachykinins and bombesin-like peptides. (1979) (13)
Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide (2011) (13)
Elucidation of structural requirements of mastoparan for mast cell activation-toward the comprehensive prediction of cryptides acting on mast cells. (2008) (13)
New hydroxyl protecting groups of a safety-catch type removable by reductive acidolysis. (1991) (13)
A fluoride ion deprotection strategy in peptide synthesis. Combination with selective deprotection using the dilute methanesulfonic acid of alpha-amino protecting groups. (1988) (13)
Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272. (2008) (13)
A HPLC study of adsorption of organic solutes on cellulose acetate. (1985) (13)
SYNTHESIS OF HUMAN ENDOTHELIN-1 BY REGIOSELECTIVE DISULFIDE FORMATION USING THE SILYL CHLORIDE-SULFOXIDE SYSTEM (1995) (12)
Click Peptide Concept: O‐Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule (2011) (12)
Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP (1995) (12)
Syndyphalin, an enkephalin-like peptide with prolonged subcutaneous analgesic activity. (1981) (12)
Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position. (2013) (12)
DMF Decomposition and Nitrogen Removal Performance by a Mesh-Filtration Bioreactor under Acidic Conditions (2009) (12)
DETERMINATION OF THE RATE OF MONOMER INTERCHANGE IN A LIGAND-BOUND HOMODIMERIC PROTEIN FROM NOESY CROSS PEAKS : APPLICATION TO THE HIV PROTEASE/KNI-52 9 COMPLEX (1999) (12)
Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles. (2011) (12)
Studies on peptides. LIX. Synthesis of the nonatriacontapeptide corresponding to the entire amino acid sequence of porcine adrenocorticotropic hormone. (1976) (12)
'Click peptide' using production of monomer Aβ from the O-acyl isopeptide: application to assay system of aggregation inhibitors and cellular cytotoxicity. (2011) (12)
Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. (2007) (11)
Mitochondrial protein‐derived cryptides: Are endogenous N‐formylated peptides including mitocryptide‐2 components of mitochondrial damage‐associated molecular patterns? (2016) (11)
Solvent Effects on Stereo and Regioselectivities of Ring-opening Reaction of Epoxide with Aluminum Chloride (1976) (11)
Pesticides Separation by Nanofiltration Membranes. (1996) (11)
Trimethylacetamidomethyl (Tacm) Group, a New Protecting Group for the Thiol Function of Cysteine (1990) (11)
A deblocking method using thioether-sulfonic acid systems. Application to the synthesis of met-enkephalin. (1979) (11)
A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide. (2013) (11)
Synthesis of [27-Tyr]-cholecystokinin-pancreozymin (CCK-PZ). (1976) (11)
Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid. (2007) (11)
Epimerization‐free synthesis of cyclic peptide by use of the O‐acyl isopeptide method (2010) (11)
A reductive acidolysis final deprotection strategy in solid phase peptide synthesis based on safety-catch protection. (1997) (11)
Synthesis of amyloid beta peptide 1-42 (E22Delta) click peptide: pH-triggered in situ production of its native form. (2009) (10)
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. (2018) (10)
Binding characteristics of KNI-272 to plasma proteins, a new potent tripeptide HIV protease inhibitor. (1996) (10)
Identification and endothelin‐induced activation of multiple extracellular signal‐regulated kinases in aortic smooth muscle cells (1992) (10)
The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, KNI-272, in beagle dogs. (1996) (10)
Studies on Peptides. XXVIII. Synthesis of the Docosapeptide which Embodies the Entire Amino Acid Sequence of β-Melanocyte-stimulating Hormone from Human Pituitary Gland (1970) (10)
Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere. (2003) (10)
Syndyphalin‐33, a synthetic tripeptide alkylamide with prolonged analgesic activity (1981) (10)
A practical synthesis of the [(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl]-L-histidine moiety (P4-P2) in renin inhibitors (1990) (10)
Efficient solid phase peptide synthesis (2009) (10)
Crystal Growth Procedure of HIV-1 Protease-Inhibitor KNI-272 Complex for Neutron Structural Analysis at 1.9 Å Resolution (2010) (10)
PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN (1983) (10)
Molecular sieving effects of disk-shaped molecules on reverse osmosis and nanofiltration separation (2017) (10)
A Fluorogenic Probe for γ‐Glutamyl Cyclotransferase: Application of an Enzyme‐Triggered O‐to‐N Acyl Migration‐Type Reaction (2013) (9)
Synthesis of O-acyl isopeptides. (2013) (9)
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position. (2014) (9)
The effect of co-existing solutes on arsenate removal with hydrotalcite compound. (2010) (9)
A spot test for ammonium ion by the color band formation method. (2007) (8)
Synthesis and conformation of an analog of the helix‐loop‐helix domain of the Id1 protein containing the O‐acyl iso‐prolyl‐seryl switch motif (2010) (8)
Tetrafluoroboric acid, a useful deprotecting reagent in peptide synthesis. (1989) (8)
Establishment of a biological assay system for human retroviral protease activity. (2005) (8)
Aspartic protease inhibitors as drug candidates for treating various difficult-to-treat diseases (2014) (8)
Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV‐1 protease inhibitor, KNI‐272, in rats after intravenous administration (1994) (8)
Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights (2018) (8)
Design, synthesis, and biophysical properties of a helical Abeta1-42 analog: Inhibition of fibrillogenesis and cytotoxicity. (2008) (7)
Syntheses and biological activities of atrial natriuretic polypeptide analogs (1987) (7)
Design and synthesis of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic. (1995) (7)
Detection tube method for trace level arsenic (2015) (7)
Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors. (2011) (7)
"Click peptide" based on the "o-acyl isopeptide method": control of A beta1-42 production from a photo-triggered A beta1-42 analogue. (2006) (7)
Application of plug–plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin‐binding fragments selected from a digested mixture of reduced BSA (2014) (7)
Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (2004) (7)
Verification of protein disulfide bond arrangement by in‐gel tryptic digestion under entirely neutral pH conditions (2010) (7)
Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells. (2008) (7)
Design and Synthesis of Potent β-Secretase (BACE1) Inhibitors with P′1 Carboxylic Acid Bioisosteres. (2006) (7)
Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors. (2011) (7)
Total Synthesis of Antimicrotubule Diketopiperazine Derivatives: Phenylahistin and Aurantiamine. (2001) (6)
Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the Nim-Function of Histidine (1980) (6)
An online solid phase extraction method for the determination of ultratrace level phosphate in water with a high performance liquid chromatograph (2014) (6)
Synthesis of novel amino acids, l-bis-tetrahydrofuranylglycines (2002) (6)
Structure--activity relationship of fluorine-containing renin inhibitory peptides based upon the tertiary structure of human renin. (1988) (6)
An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease. (2002) (6)
S‐acyl isopeptide method: Use of allyl‐type protective group for improved preparation of thioester‐containing S‐acyl isopeptides by Fmoc‐based SPPS (2011) (5)
Tyrosine in position 4 is the key amino acid for the binding of angiotensin II to human arteriolar receptor. (1987) (5)
Biological removal characteristics of phenol with filtration bio-reactor (2015) (5)
Super-active enkephalin analogues (1981) (5)
A spot test for nitrite and nitrate detection by color band length and number of colored zebra-bands formed in a mini-column (2010) (5)
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum. (2014) (5)
Synthesis and analgesic activity of neo-kyotorphin analogs. (1985) (5)
N im -p-methoxyphenylsulphonylhistidine, a new derivative for peptide synthesis (1979) (5)
Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5,8-dioxo-4,7-diazanonanoyl]-N-tert-butyl-1,3-thiazolidine-4-carboxamide. (2004) (5)
Ammonium detection by formation of colored zebra-bands in a detecting tube. (2010) (5)
Synthesis of rat brain natriuretic peptide 45 using tetrafluoroboric acid deprotection and silyl chloride disulfide formation. (1993) (5)
Oligoarginine-based prodrugs with self-cleavable spacers for caco-2 cell permeation. (2008) (5)
2 – Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis (1995) (5)
Targets of a protease inhibitor, KNI‐272, in HIV‐1‐infected cells (2001) (5)
A New Class of Anti‐HIV Agents: Synthesis and Activity of Conjugates of HIV Protease Inhibitors with a Reverse Transcriptase Inhibitor. (1999) (4)
New human renin inhibitory peptides: angiotensinogen transition-state analogues containing novel Leu-Val replacement and a retro-inverso amide bond. (1988) (4)
Synthesis of human C-type natriuretic peptide 22 using chlorotrityl resin and tetrafluoroboric acid deprotection. (1996) (4)
Erratum to “Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin” [Bioorg. Med. Chem. 16 (2008) 10049–10060] (2009) (4)
Organic Chemistry and Medicinal Chemistry Based on α-Hydroxy-β-amino Acids (2005) (4)
Development of [Ile40]HTLV‐I protease inhibition assay using novel fluorogenic and chromogenic substrate (2011) (4)
Generation of monoclonal antibodies against mitocryptide‐2: toward a new strategy to investigate the biological roles of cryptides (2017) (4)
Solution-phase synthesis of porcine brain natriuretic peptide (pBNP) using S-trimethylacetamidomethylcysteine. (1990) (4)
Tetrapeptides, as small‐sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1 (2010) (4)
Studies on peptides. XLIII. Synthesis of two protected peptides related to the C-terminal portion of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (4)
Synthesis and activity of a newly isolated analgesic pentapeptide, neo-kyotorphin. (1983) (4)
Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-1. (2015) (4)
Absorption of new HIV‐1 protease inhibitor, KNI‐272, after intraduodenal and intragastric administrations to rats: Effect of solvent (1995) (4)
Studies on Peptides. XXXI. Synthesis of Two Model Pentapeptides related to Clostridial Ferredoxin (1971) (4)
Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region. (2005) (4)
Synthesis and biological evaluation of a 13N-labeled opioid peptide. (1992) (4)
Nutrient Loss from a Tea Plantation Area in Japan (2009) (4)
Studies on Peptides. XXIX. p-Methoxybenzyl Mixed Carbonates (1970) (4)
[Anti-HIV compounds]. (1993) (4)
KNI-272, a highly selective and potent peptidic HIV protease inhibitor. (2001) (4)
N in -Diphenylphosphinothioyltryptophan, a useful derivative for peptide synthesis by the methanesulphonic acid–thioanisole system and fluoride ion deprotection methods (1988) (4)
Structure of HIV-1 protease with KNI-272: a transition state mimetic inhibitor containing allophenylnorstatine. (1995) (4)
Discovery of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease (2017) (3)
Removal of phosphite and sulfate from electroless nickel–phosphorus plating bath with hydrotalcite for the management of watershed (2013) (3)
“Click Peptides” — Chemical Biology‐Oriented Synthesis of Alzheimer′s Disease‐Related Amyloid β Peptide (Aβ) Analogues Based on the “O‐Acyl Isopeptide Method” (2006) (3)
Fibrous adsorbent for removal of aqueous aromatic hydrocarbons. (2007) (3)
An approach to the targeted attachment of peptides and proteins to solid supports. (1976) (3)
Studies on peptides. LXVII. Synthesis of the hexadecapeptide corresponding to position 1 through 16 of porcine cholecystokinin-pancreozymin (CCK-PZ). (1976) (3)
Acid‐Catalyzed Monodehydro‐2,5‐diketopiperazine Formation from N‐α‐Ketoacyl Amino Acid Amides. (2009) (3)
A deprotection method using tetrachlorosilane-trifluoroacetic acid scavengers by a ‘reductive acidolysis’ mechanism: Application to the synthesis of a novel tachykinin peptide, scyliorhinin I (1988) (3)
Effect of Composition and Structure of Coating Polymers on Moisture Transporting Properties in Waterproof/Moisture-permeable Fabrics Prepared by Wet-Coagulation Process (1996) (3)
Analysis of amide bond formation with an alpha-hydroxy-beta-amino acid derivative, 3-amino-2-hydroxy-4-phenylbutanoic acid, as an acyl component: byproduction of homobislactone. (2001) (3)
A Novel Dipeptide‐based HIV Protease Inhibitor Containing Allophenylnorstatine (2004) (3)
Effect of properties of feed solution on transport of inorganic solutes in reverse osmosis. (1978) (3)
A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate (1990) (3)
A new stepwise deprotection method using reductive acidolysis followed by fluoride ion in solid phase peptide synthesis (1993) (3)
A membrane extraction method for trace level phosphate analysis (2015) (3)
Effects of Water Deprivation and Sodium Load on Atrial Natriuretic Polypeptide in Rat Brain (1986) (3)
Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages (2021) (3)
Studies on Peptides. XXXV. Some p-Methoxybenzyloxycarbonyl-Amino Acid Derivatives (1973) (3)
Solution syntheses of two enkephalin-containing peptides, peptide E and dynorphin(1-24), using Nin-(2,4,6-triisopropylphenylsulfonyl)tryptophan. (1989) (3)
Corrigendum to Significance of interactions of BACE1―Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold (2009) (3)
Syndyphalin SD‐25: A highly selective ligand for μ opiate receptors (1982) FEBS Letters 141,203–206. (1982) (3)
Racemization-free segment condensation based on the O-acyl isopeptide method: toward a chemical protein synthesis on solid support. (2009) (2)
Deprotecting Reagents : SiCl4-CF3COOH-Scavenger (1990) (2)
Synthesis of a newly isolated opioid tridecapeptide, rimorphin, from pituitary using a trifluoroacetic acid-thioanisole deprotection system. (1983) (2)
Delivery of Peptide Drugs (2015) (2)
Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis (1996) (2)
Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP). (1990) (2)
Antiinflammatory effects of opioid peptides and opiates on dextran-induced eduma in rat paw (1984) (2)
O‐Acyl isopeptide method: development of an O‐acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1‐42 isopeptide (2014) (2)
Total Synthesis of Human Insulin by Regioselective Disulfide Formation Using the Silyl Chloride-Sulfoxide Method. (1994) (2)
Waste sludge reduction with a pilot-scale membrane bioreactor for point source pollution management (2013) (2)
Rational Drug Design of HTLV-I Protease Inhibitors (2009) (2)
EFFICIENT REMOVAL OF PROTECTING GROUPS BY A ′PUSH‐PULL′ MECHANISM. II. DEPROTECTION OF O‐BENZYLTYROSINE WITH A THIOANISOLE‐TRIFLUOROACETIC ACID SYSTEM WITHOUT O‐TO‐C REARRANGEMENTS (1980) (2)
Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin (2005) (2)
Medicinal Chemistry of α‐Hydroxy‐β‐Amino Acids (2011) (2)
Total Synthesis of (-)-Mirabazole B Using a Chloroimidazolidium Reagent, CIP (1996) (2)
Comparative properties of Aβ1-42, Aβ11-42, and [Pyr¹¹]Aβ11-42 generated from O-acyl isopeptides. (2013) (2)
Structure-activity relationships of atrial natriuretic factor (ANF) receptor agonists (1990) (2)
Analgesic and other pharmacological activities of an enkephalin analogue, syndyphalin (SD)-25. (1982) (2)
Phosphorus Removal with Hydrotalcite Compound (2002) (2)
Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors (2009) (2)
Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum (2004) (2)
Advanced Treatment of Night Soil with Membrane Separation Process (1990) (2)
KNI‐272, a Highly Selective and Potent Peptidic HIV Protease Inhibitor (2010) (2)
Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner. (2014) (2)
A new two-dimensional protection strategy for solid phase peptide synthesis: Use of a safety-catch type of ester linkage-resin cleavable by reductive acidolysis (1992) (2)
Studies on Peptides. XXV. A Convenient Procedure for the Preparation of p-Methoxybenzyl Azidoformate (1969) (2)
Discovery of Peptide Drugs as Enzyme Inhibitors and Activators (2015) (2)
Convergent Synthesis of (‐)‐Mirabazole B (XII) Using a Chloroimidazolidium Coupling Reagent, CIP. (1997) (1)
SYNTHESES AND BIOLOGICAL ACTIVITIES OF SEVERAL NEWLY ISOLATED NATRIURETIC PEPTIDES (1991) (1)
Design and Synthesis of Peptide Lead Drugs (1994) (1)
The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain. (2004) (1)
A new synthesis of (+)-negamycin and its derivatives as a potential therapeutic agent for Duchenne muscular dystrophy treatment. (2009) (1)
Reverse Osmosis Separations of Aqueous NaCl–Organic Solute Systems (1985) (1)
Editorial: Protease inhibitors (1999) (1)
Structure-function relationships of the melanotropins. (1975) (1)
Peptide Coupling Reagents : BOP and Congeners (1990) (1)
Quantitative evaluation of refolding conditions for a disulfide‐bond‐containing protein using a concise 18O‐labeling technique (2011) (1)
Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry (2004) (1)
Effect of α-rat Atrial Natriuretic Polypeptide on Blood Pressure in Rats Bilateral Renal Vessels Ligated (1985) (1)
Synthesis and in vivo evaluation of N-13 labeled opioid peptide analogue for PET opiate receptor studies (1989) (1)
Fmoc‐based solid phase chemical synthesis of 71‐meric neuregulin 1‐β1, an epidermal growth factor‐like domain (2008) (1)
[Development of HIV protease inhibitors as anti AIDS drugs: molecular design based on substrate transition state]. (1998) (1)
Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography (2009) (1)
The “ O -Acyl Isopeptide Method” for the Synthesis of Alzheimer’s Disease-Related Amyloid β Peptide (Aβ) 1–42 (2006) (1)
Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs (2003) (1)
Protease Inhibitors: Design and New Features (2003) (1)
Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands (2005) (1)
Application of intramolecular carbonate-carbamate migration (2006) (1)
Tetrafluoroboric Acid as a Useful Deprotecting Reagent in Fmoc-Based Solid-Phase Peptide Syntheses (Fmoc = Fluoren-9-ylmethoxycarbonyl). (1990) (1)
Evaluation of interaction between organic solutes and a membrane polymer by an inverse HPLC method (2014) (1)
High Performance Aerobic Digestion of Organic Sludge using a Pilot-scale Mesh-filtration Bioreactor (2008) (1)
Radioimmunoassay for Atrial Natriuretic Polypeptide (1985) (1)
Click Peptides: Design and Applications (2008) (1)
Statistical Distribution and Estimation Methods of 75% Probability of BOD in River Water. (1996) (1)
[Kynostatin (KNI)-272--a rationally designed tripeptide inhibitor of HIV protease]. (1993) (1)
Special issue : fifth Symposium on Biodilm Process Research.Removal function of pollutanto by an anaerobic - aerobic filter bed system and its numerical analysis. (1991) (1)
Effect of α-human Atrial Natriuretic Polypeptide (α-hANP) on Canine Renal Na+-K+ ATPase Activity (1985) (1)
SYNTHESIS AND ACTIVITY OF C-TERMINAL HEPTAPEPTIDES OF TACHYKININS AND BOMBESIN-LIKE PEPTIDES (1979) (1)
Protease inhibitors (1999) (1)
An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence (2003) (1)
Studies on peptides. LIII. Synthesis of the docosapeptide corresponding to the entire amino acid sequence of porcine ACTH-like intermediate lobe peptide (CLIP). (1975) (1)
“O, N-Acyl migration”-type prodrugs of dipeptide HIV protease inhibitors (2002) (1)
Controlled Drug Release: New Water‐Soluble Prodrugs of an HIV Protease Inhibitor. (2001) (1)
Synthesis of Di‐ and Tripeptide Analogues Containing α‐Ketoamide as a New Core Structure for Inhibition of HIV‐1 Protease. (2001) (1)
Immuohistochemical demonstration of alpha-atrial natriretic plypeptide-containing neurons in the rat brain. (1985) (1)
The Plasmepsin Family as Antimalarial Drug Targets (2011) (1)
Efficient Synthesis of Peptaibol Using a Chloroimidazolidium Coupling Reagent, CIP. (1997) (1)
Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry. (2009) (1)
Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity (2004) (1)
Inverse HPLC approach for the evaluation of repulsive interaction between ionic solutes and a membrane polymer (2015) (1)
Paclitaxel Prodrugs: Toward Smarter Delivery of Anticancer Agents (2007) (1)
Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin (2005) (1)
Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors (2001) (1)
Studies on peptides. CXXXVII. Conventional solution synthesis of porcine hypothalamic growth hormone releasing factor (pGRF). (1986) (1)
A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62). (1991) (1)
The Effects of Molecular Width of Organic Solute on Membrane Permeability (1993) (1)
Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique (2011) (1)
Performances of Aerobic Digestion and Biological Nitrogen Removal for Johkasou Raw Sludge (2008) (1)
Acquisition of neutralizing antibody against mouse mitocryptide-2 and investigation of its physiological roles (2017) (0)
Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide (2011) (0)
Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines (2006) (0)
Development of an O‐Acyl Isopeptide Method (2007) (0)
Characterization of adsorbed materials on activated carbon and liquid phase regeneration. (1984) (0)
Synthesis of a Novel Water-Soluble Paclitaxel Prodrug, Arginine-Isotaxel, and its Physicochemical and Caco-2 Transport Properties (2007) (0)
Identification and Structure-Activity Studies of Novel Cryptides Hidden in Mitochondrial Proteins (2013) (0)
An Expedient Synthesis of Nα-Protected-L-tetrahydrofuranylglycine and Its Application in the Synthesis of Novel Substrate Based Inhibitors of HIV-1 Protease. (2003) (0)
Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents (2009) (0)
Efficient Coupling of α,α‐Dimethyl Amino Acid Using a New Chloro Imidazolidium Reagent, CIP. (1994) (0)
Synthesis of Novel Amino Acids, L‐Bis‐tetrahydrofuranylglycines. (2002) (0)
Atrial Natriuretic Polypeptides in SHR and SHR Stroke-Prone (1985) (0)
[Approval of HIV protease inhibitors as the AIDS therapeutics of next generation]. (1997) (0)
Anchoring of Fmoc Amino Acid to 4-Alkoxybenzyl Alcohol Resin Using a New Esterification Reagent (I), (II). (2010) (0)
Design and Synthesis of a Covalently Linked HIV-1 Protease Dimer Analogue and Peptidomimetic Inhibitors (2010) (0)
Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation (2009) (0)
Development of New Photoresponsive Paclitaxel Prodrug (2007) (0)
A Novel Method for the Synthesis of Difficult Sequence-Containing Peptides via O-Acyl Isopeptides : The Use of O-N Intramolecular Acyl Migration Reaction (2004) (0)
Structure-activity relationships of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic (1993) (0)
[Discovery of cryptides and their novel signaling pathways]. (2010) (0)
Studies on peptides. XL. Synthesis of the protected dodecapeptide corresponding to positions 1 to 12 of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (0)
O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids (2006) (0)
PEPTIDES. LVII. SYNTHESIS OF OCTADECAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF EQUINE β-MELANOCYTE-STIMULATING HORMONE (1976) (0)
A new deprotecting procedure in peptide synthesis (1991) (0)
Growth of high-quality and large crystals of HIV protease for neutron crystallography (2008) (0)
Click peptide by use of the O-acyl isopeptide method: Production of Amyloid Beta peptide from water-soluble analogue (2009) (0)
The promising anti-HIV agent kynostatin (KNI)-272: A highly selective and super-active HIV protease inhibitor containing allophenylnorstatine (1994) (0)
Synthesis of O-Acyl Isopeptide by Use of Native Chemical Ligation to Efficiently Construct Hydrophobic Polypeptide (2012) (0)
Studies on peptides. LVII. Synthesis of the octadecapeptide corresponding to the entire amino acid sequence of equine beta-melanocyte-stimulating hormone. (1975) (0)
Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease (2002) (0)
A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis (2009) (0)
A process for the preparation of peptide derivatives and their salts (1993) (0)
"Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues (2006) (0)
SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES (1987) (0)
Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres (2006) (0)
Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors (2011) (0)
A New Stepwise Deprotection Method using Reductive Acidolysis Followed by Fluoride Ion in Solid Phase Peptide Synthesis. (1994) (0)
The crystal structure of htlv protease complexed with the inhibitor KNI-10681 (2010) (0)
Click Peptide: Water-Soluble Precursor Producing Monomer Amyloid β Peptide in Situ (2009) (0)
Protease inhibitors (2007) (0)
Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption (2003) (0)
Surface Analysis of the Reverse Osmosis Membranes Used for Advanced Treatment of Human Excreta. (1994) (0)
Enzyme Inhibitors, Aspartic Proteases (2019) (0)
STUDIES ON PEPTIDES PART 39, N-ISOBUTOXYCARBONYL-2-ALKOXY-1,2-DIHYDROQUINOLINE DERIVATIVES, AS COUPLING REAGENTS IN PEPTIDE SYNTHESIS (1974) (0)
3-18 Characterization of bacteria isolated from an acidophilic nitrification reactor(Waste water treatment ecosystem,Oral presentation) (2007) (0)
INHIBITEUR DE LA β-SECRÉTASE (2006) (0)
Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors (2003) (0)
Ligand recognition mechanisms of formyl peptide receptor 2 (2017) (0)
General Report on the 42^ Annual Conference of JSWE (2008) (0)
Syntheses and structure-activity relationships of natriuretic peptides (1993) (0)
Synthesis of biotin-tagged diketopiperazine-based anti-microtubule agents and tubulin photoaffinity labeling. (2009) (0)
Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability (2005) (0)
Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease (2012) (0)
Kynostatin (KNI)‐227 and ‐272, Highly Potent Anti‐HIV Agents: Conformationally Constrained Tripeptide Inhibitors of HIV Protease Containing Allophenylnorstatine. (1993) (0)
Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization (2009) (0)
Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine (2006) (0)
A Convenient Synthetic Method for Monodehydro-2,5-diketopiperazines (2006) (0)
Intact Cell-based SPR Analyses of Interactions between EGF and its Receptor (2011) (0)
STUDIES ON PEPTIDES PART 35, SOME P‐METHOXYBENZYLOXYCARBONYL‐AMINO ACID DERIVATIVES (1973) (0)
The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) (2003) (0)
Efficient Synthesis of Alamethicin using a Newly Developed Coupling Reagent, CIP (1995) (0)
Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells (2007) (0)
Effects of DOCA and Salt Overloading on the Content of α-Rat Atrial Natriuretic Polypeptide-like Immunoreactivity in Rat Atrium (1985) (0)
P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION (2006) (0)
P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT" (2006) (0)
Investigation of Signaling Mechanisms Induced by Mitocryptides in Neutrophilic/granulocytic Cells (2008) (0)
Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors (2006) (0)
Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel Beta-Sheet Structure Formed by Abeta on GM1 Clusters (2019) (0)
The synthesis of bioactive peptides based on O-Acyl Isopeptide Method: Application of O-acyl isodipeptide units (2007) (0)
Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides (2011) (0)
Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes (2007) (0)
“MINIMAL SEGMENT” OF ENKEPHALIN FOR ANALGESIA: SYNDYPHALIN (SD)-33, A SIMPLE TRIPEPTIDE ALKYLAMIDE WITH PROLONGED SUBCUTANEOUS ANALGESIC ACTIVITY (1981) (0)
KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic (1998) (0)
New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor (2000) (0)
Solution-phase synthesis of alpha-rat atrial natriuretic peptide (alpha-rANP). (1990) (0)
Tetrafluoroboric Acid, a Useful Deprotecting Reagent in Peptide Synthesis.AB: (1990) (0)
A New Class of Amino Protecting Group Removable by Reductive Acidolysis: The 4-Methylsulfinylbenzyloxycarbonyl (Msz) Group. (1990) (0)
A Novel Dipeptide-Based HIV Protease Inhibitor Containing Allophenylnorstatine. (2005) (0)
crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor (2010) (0)
Role of pro-region in secretion of Escherichia coli heat-stable enterotoxin STp: (2009) (0)
Atrial Natriuretic Polypeptides in Rat Heart and Plasma (1985) (0)
O—N Intramolecular Acyl Migration Strategy in Water-Soluble Prodrugs of Taxoids. (2004) (0)
Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues (2011) (0)
Bioactive Peptides and Drug Discovery (2020) (0)
A Simple Diastereoselective Synthesis of Cyclohexylnorstatine and Allocyclohexylnorstatine. (1990) (0)
Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy (2011) (0)
SYNTHESES AND OPIOID ACTIVITIES OF ENKEPHALIN-AND DERMORPHIN-RELATED PEPTIDES (1984) (0)
Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide (2011) (0)
SYNTHESIS AND ANALGESIC ACTIVITY OF NEO-KYOTORPHIN ANALOGS (1985) (0)
Crystal Structure of HIV-1 Protease Complexed with KNI-1689 (2010) (0)
SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES (1990) (0)
SYNTHESES AND STRUCTURE-ACTIVITIES RELATIONSHIPS OF SMALLSIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES WITH POTENT ACTIVITY (1992) (0)
"Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants (2006) (0)
Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers (1995) (0)
Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure (2011) (0)
PEPTIDES. LIII. SYNTHESIS OF THE DOCOSAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF PORCINE ACTH-LIKE INTERMEDIATE LOBE PEPTIDE (CLIP) (1976) (0)
Design and Synthesis of an Orally Potent Human Renin Inhibitor (R,S,S,R)-(I) Containing a Novel Amino Acid, Cyclohexylnorstatine (2R,3S)-(II). (1990) (0)
Derives peptidiques a activite inhibitrice de la $g(b)secretase (2004) (0)
SYNTHESIS AND ACTIVITY OF A NEWLY ISOLATED ANALGESIC PENTAPEPTIDE, NEO-KYOTORPHIN (1983) (0)
Developments in peptide synthesis and peptidomimetic chemistry: HIV protease analogs and substrate-based inhibitors (1999) (0)
Novel Neutrophil-Activating Cryptides Hidden in Mitochondrial Cytochrome c : Identification and Structure-Activity Studies (2012) (0)
Synthesis of Human Endothelin‐1 by Regioselective Disulfide Formation Using the Silyl Chloride‐Sulfoxide System. (1995) (0)
NIM-P-METHOXYPHENYLSULFONYLHISTIDINE, A NEW DERIVATIVE FOR PEPTIDE SYNTHESIS (1980) (0)
Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy (2008) (0)
Evans’ Asymmetric Alkylation on Solid Supports (2005) (0)
A novel approach for the hydrophobic peptides synthesis and purification through O-N intramolecular acyl migration reaction (2004) (0)
Solution-phase synthesis of α-human atrial natriuretic peptide (α-hANP) (1990) (0)
Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer (2008) (0)
Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value? (2011) (0)
Phenylahistin, a Small Dipeptidic Colchicine-Like Anti-Microtubule Agent: Total Synthesis and SAR Study of the Derivatives (2001) (0)
"O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42 (2005) (0)
Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions (2005) (0)
Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs (1996) (0)
"Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues (2007) (0)
Synthesis of polylactides with side chain functionality: ring-opening polymerimerization of a homobislactone prepared from lysine. (2009) (0)
STUDIES ON PEPTIDES PART 44, SYNTHESIS OF THE BASIC TRYPSIN INHIBITOR FROM BOVINE PANCREAS (KUNITZ AND NORTHROP) BY THE FRAGMENT CONDENSATION PROCEDURE ON POLYMER SUPPORT (1974) (0)
Investigation of signaling mechanisms induced by mitocryptide-3, a novel neutrophil-activating peptide derived from a mitochondrial transit sequence (2017) (0)
Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt (2002) (0)
Prodrug Forms of Peptidomimetic HIV Protease Inhibitors Using Intramolecular Cyclization Reaction (2001) (0)
Efficient solid phase peptide synthesis. Use of methanesulfonic acid alpha-amino deprotecting procedure and new coupling reagent, 2-(benzotriazol-1-yl)oxy-1,3-dimethylimidazolidinium hexafluorophosphate (BOI). (1993) (0)
Removal of Trace Organic Pollutants by Membrane Filtration (2002) (0)
Growth of large protein crystals for neutron crystallography by hanging a seed crystal (2008) (0)
Studies on peptides. CXXXVIII. Conventional solution synthesis of bovine hypothalamic growth hormone releasing factor (bGRF). (1986) (0)
Synthesis of an HIV-1 protease dimer analog covalently linked by a disulfide bridge (1999) (0)
Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept (1992) (0)
Disulfide bond formation in peptides by silylchloride-sulfoxide: Scope and applications (1993) (0)
ILVIII-9 DEFYING DIFFICULT DISEASES : DESIGN OF PROTEASE INHIBITORS AND PRODRUG FORMS(Drug Discovery and Developments) (2006) (0)
Nin-Diphenylphosphinothioyltryptophan, a Useful Derivative for Peptide Synthesis by the Methanesulfonic Acid - Thioanisole System and Fluoride Ion Deprotection Methods. (1988) (0)
Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption (2007) (0)
Structure activity relationships of mitocryptide-3 for the elucidation of ligand recognition mechanisms of its receptors (2017) (0)
Medicinal Science Studies Based on Synthetic Peptide Chemistry (2004) (0)
O—N Intramolecular Alkoxycarbonyl Migration of Typical Protective Groups in Hydroxyamino Acids. (2006) (0)
Human T-cell Leukemia Virus Type I (HTLV-I) Retropepsin (2013) (0)
High-throughput Screening Method for Ligand Peptides Using Capillary Electrophoresis-Mass Spectrometry (CE-MS) (2009) (0)
Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657 (2018) (0)
Evaluation of Malarial Protease Plasmepsin Inhibitors Containing Hydroxymethylcarbonyl Isostere (2006) (0)
O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids (2005) (0)
Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties (2008) (0)
P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING (2006) (0)
Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 (2003) (0)
STUDIES ON PEPTIDES PART 50, ACIDOLYSIS OF PROTECTING GROUPS IN PEPTIDE CHEMISTRY BY FLUOROSULPHONIC ACID AND METHANESULPHONIC ACID (1975) (0)
A Practical Synthesis of an Orally Potent Renin Inhibitor, Isopropyl (2R,3S)-4-Cyclohexyl-2-hydroxy-3-(N-((2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl)-L-histidyl)aminobutyrate (1990) (0)
New disulfide bond-forming reactions for peptide and protein synthesis. (1994) (0)
Syntheses of Natriuretic Peptides Using a New S -Protecting Group, S -Trimethylacetamidomethyl (Tacm) Group (1994) (0)
Effects of α-human atrial natriuretic polypeptide on vascular strips and perfused mesenteric vessels of SHR and WKY (1985) (0)
Quantitative Analyses of Disulfide Bond Formation in Proteins Using ^ O-Labeled Peptide Standards (2012) (0)
Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic (2004) (0)
Functional Analysis of Mitocryptides with Their Monoclonal Antibodies (2013) (0)
Two new reagents for the coupling of sterically hindered amino acids (1993) (0)
Design of HIV protease inhibitors with effective antiviral activity: Use of allophenylnorstatine as a transition-state mimic (1993) (0)
Structure—Activity Relationship Studies of Chloromethyl Ketone Derivatives for Selective Human Chymase Inhibitors. (2010) (0)
Synthesis of Cystine‐Peptide by a New Disulfide Bond‐Forming Reaction Using the Silyl Chloride‐Sulfoxide System. (1991) (0)
Chemical Synthesis of 71-meric Neuregulin 1-β1 (2009) (0)
Small-sized HIV protease inhibitors containing allophenyinorstatine exhibit antiviral activities (1996) (0)
Efficient Total Synthesis of (+)-Negamycin and Its Derivatives (2009) (0)
Nouveaux composes de tripeptides et medicaments anti-sida (1997) (0)
Small Peptide-based Medicinal Chemistry for Intractable Disease (2009) (0)
Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker (1996) (0)
THE EFFECTS OF SALT ADDITION ON FOULING IN REVERSE OSMOSIS (1983) (0)
CIP and CIB: Two new reagents for the esterification or difficult coupling of sterically hindered amino acids (1993) (0)
Design and Synthesis of β-Secretase Inhibitors: Optimization at the P4 and P1′ Positions (2006) (0)
Solution NMR Studies of the HIV-1 Protease/Inhibitor Complex : The HIV-1 Protease Catalytic Aspartyl Side-Chain Carboxyl Groups Have Distinct Protonation States in the Complex Formed with the Asymmetric Inhibitor KNI-272 (1996) (0)
Oxamide Replacement in Pseudo-Symmetric HIV Protease Inhibitor Involving Multiple Bridging Water Molecules (2013) (0)
SYNTHESES OF CYSTINE-PEPTIDES BY A NEW DISULPHIDE BOND FORMING REACTION (1992) (0)
Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide (2008) (0)
Cryptides : Non-Classical Bioactive Peptides Hidden in Protein Structures (2011) (0)
Defying Difficult Diseases : Peptide Chemistry in Medicinal Science (2009) (0)
A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide (2009) (0)
[Structural analysis of protease-inhibitor system using graphics]. (1997) (0)
Design and SAR Study of Tripeptidic BACE1 Inhibitors (2012) (0)
Neuronal opiate receptors in rabbit ear artery. (1983) (0)
Click Peptide : In Situ Production of pyroGlu-Abeta from the O-Acyl Isopeptide (2011) (0)
An efficient synthesis of tryptophan-containing cystine peptide using the silyl chloride-sulfoxide system (1999) (0)
Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II (2007) (0)
STUDIES ON PEPTIDES. LXVII. SYNTHESIS OF THE HEXADECAPEPTIDE CORRESPONDING TO O POSITION 1 THROUGH 16 OF PORCINE CHOLECYSTOKININ-PANCREOZYMIN (CCK-PZ) (1977) (0)
Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin (2009) (0)
Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety (2007) (0)
Mitocryptide-3: physiological significance of a novel neutrophil-activating peptide derived from a mitochondrial transit signal sequence (2017) (0)
Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic (1995) (0)
STUDIES ON PEPTIDES PART 43, SYNTHESIS OF TWO PROTECTED PEPTIDES RELATED TO THE C-TERMINAL PORTION OF THE BASIC TRYPSIN INHIBITOR FROM BOVINE PANCREAS (KUNITZ AND NORTHROP) (1974) (0)
Sludge Reduction Performance of Aerobic Digestion Reactors for Johkasou System (2007) (0)
Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support (2008) (0)
Fmoc-Based Solid-Phase Peptide Synthesis Using a New t-Alcohol Type 4-(1′,1′-Dimethyl-1′-hydroxypropyl)phenoxyacetyl Handle (DHPP)-Resin (Fmoc = Fluoren-9-ylmethoxycarbonyl). (1990) (0)
Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method (1998) (0)
Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075 (2007) (0)
Controlled Drug Release : Design and Application of New Water-soluble Prodrugs (2002) (0)
[Trends and problems in the development of neuropeptide drugs]. (1990) (0)
Nitrogen Removal Performance in Biological Decomposition on N, N－Dimethylformamide under Acidic Conditions (2009) (0)
The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) (2003) (0)
Cryptide Signaling and the Exocytotic Mechanisms Induced by Amphiphilic Peptides (2009) (0)
Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment (2011) (0)
Design of Double-Drug-Type Anti-HIV Agents (2001) (0)
Effect of Synthetic Atrial Natriuretic Polypeptide on Diuresis, Natriuresis and Blood Pressure in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY) (1985) (0)
Trimethylacetamidomethyl (Tacm) Group, a New Protecting Group for the Thiol Function of Cysteine. (1990) (0)
Structure-Migration Rate Relationship of Water-Soluble Prodrugs of HIV-1 Protease Inhibitors Based on O→N Intramolecular Acyl Migration (2003) (0)
Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design (2011) (0)
Design and Synthesis of Substrate-Based Peptidomimetic Human Immunodeficiency Virus Protease Inhibitors Containing the Hydroxymethylcarbonyl Isostere (1996) (0)
Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog (2007) (0)
Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit" (2007) (0)
Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction (2006) (0)
Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 (2003) (0)
Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors (2011) (0)
NMR Studies on Reorientation Process of the Inhibitor Tightly Bound to HIV Protease (2000) (0)
Design of HIV protease inhibitors based on the transition state concept (1993) (0)
Studies on peptides. XLI. Synthesis of the protected hexadecapeptide corresponding to positions 13 to 28 of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop). (1974) (0)
Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleava (1991) (0)
Ring Size and Side-Chain Orientation of Inhibitory Cyclic Peptides against EGF Receptor Dimerization (2013) (0)
Structure-activity relationships of HIV protease inhibitors containing hydroxymethylcarbonyl isostere as a transition state mimic (1993) (0)
SAR study of BACE1 inhibitors containing pyridine derivatives (2009) (0)
Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10033 (2007) (0)
Design and activity of protease active site-targeted anti-HIV agents containing allophenylnorstatine (1993) (0)
Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor (1998) (0)
Kynostatins, highly selective and superpotent HIV protease inhibitors: Conformationally constrained tripeptides containing allophenylnorstatine as a transition-state mimic (1995) (0)
Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety (2007) (0)
Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent (2011) (0)
2Hp13 Characterization of predominant uncultured bacteria affiliated with the candidate phylum TM7 in an acidophilic nitrifying reactor (2009) (0)
Efficient Coupling of Dialky Amino Acid Using a Chloro Imidazolidium Reagent, CIP (1995) (0)
Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere (2006) (0)
Fluoren‐9‐ylmethyloxycarbonyl (Fmoc) Amino Acid Chloride as an Efficient Reagent for Anchoring Fmoc Amino Acid to 4‐Alkoxybenzyl Alcohol Resin. (2010) (0)
Isotope Labeling-assisted Quantitative Evaluation of Refolding Conditions of a Recombinant Disulfide Protein (2011) (0)
New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling (2007) (0)
Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine (2001) (0)
Single substitution of n‐terminal amino acid in 111In‐DTPA‐octreotide significantly affects renal accumulation (2001) (0)
Potent dipeptide HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimetic (2002) (0)
Organic Chemistry and Medicinal Chemistry Based on α‐Hydroxy‐β‐Amino Acids (2005) (0)
SOLVENT EFFECTS ON STEREO AND REGIOSELECTIVITIES OF THE RING‐OPENING REACTION OF EPOXIDE WITH ALUMINUM CHLORIDE (1976) (0)
Candida albicans secreted aspartic peptidase specificity A chromogenic combinatorial approach (2003) (0)
Synthesis of HIV-1 protease analog by ligation of bromoacetyl and mercaptoethylamide peptide prepared using disulfide linkage to solid-support (2002) (0)
Renin inhibitors designed on the basis of angiotensinogen transition state (1989) (0)

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