Yoshiki Sasai
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Japanese stem-cell biologist
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Biology
Yoshiki Sasai's Degrees
- PhD Developmental Biology Kyoto University
- Doctorate Medicine Kyoto University
Why Is Yoshiki Sasai Influential?
(Suggest an Edit or Addition)According to Wikipedia, Yoshiki Sasai was a Japanese stem cell biologist. He developed methods to guide human embryonic stem cells into forming brain cortex, eyes , and other organs in tissue culture. Sasai worked at the Riken Center for Developmental Biology in Kobe, and was Director of the Laboratory for Organogenesis and Neurogenesis. Following his involvement in the 2014 STAP cell controversy, Sasai was found dead at Riken from an apparent suicide.
Yoshiki Sasai's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A ROCK inhibitor permits survival of dissociated human embryonic stem cells (2007) (1929)
- Self-organizing optic-cup morphogenesis in three-dimensional culture (2011) (1614)
- Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity (2000) (1316)
- Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4 (1996) (1176)
- Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes (1994) (1158)
- Self-formation of optic cups and storable stratified neural retina from human ESCs. (2012) (1147)
- Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. (2008) (1135)
- Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer (1996) (796)
- A common plan for dorsoventral patterning in Bilateria (1996) (726)
- Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex (2013) (669)
- Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus (1995) (646)
- Directed differentiation of telencephalic precursors from embryonic stem cells (2005) (638)
- Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (2008) (602)
- Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. (1998) (499)
- Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. (2005) (484)
- Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity (2002) (482)
- Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. (2013) (472)
- Ectodermal patterning in vertebrate embryos. (1997) (458)
- A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin (1995) (439)
- Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. (2015) (438)
- Transplantation of Human Embryonic Stem Cell‐Derived Cells to a Rat Model of Parkinson's Disease: Effect of In Vitro Differentiation on Graft Survival and Teratoma Formation (2006) (434)
- Self-formation of functional adenohypophysis in three-dimensional culture (2011) (420)
- In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction (2009) (411)
- Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. (2010) (395)
- Cytosystems dynamics in self-organization of tissue architecture (2013) (375)
- Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue (2015) (345)
- Next-generation regenerative medicine: organogenesis from stem cells in 3D culture. (2013) (335)
- Retraction: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency (2014) (311)
- Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. (2005) (290)
- Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice (2014) (279)
- Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells (2003) (278)
- Stimulus-triggered fate conversion of somatic cells into pluripotency (2014) (271)
- Requirement of FoxD3-class signaling for neural crest determination in Xenopus. (2001) (267)
- Endoderm induction by the organizer‐secreted factors chordin and noggin in Xenopus animal caps. (1996) (263)
- Stepwise differentiation of pluripotent stem cells into retinal cells (2009) (257)
- Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration (2015) (243)
- The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor (1996) (242)
- Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue (2015) (226)
- Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. (2000) (226)
- Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm (2005) (223)
- Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation (2008) (214)
- In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. (2004) (208)
- Intrinsic transition of embryonic stem-cell differentiation into neural progenitors (2011) (202)
- Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues (2011) (190)
- In vitro organogenesis in three dimensions: self-organising stem cells (2012) (169)
- Subregional Specification of Embryonic Stem Cell-Derived Ventral Telencephalic Tissues by Timed and Combinatory Treatment with Extrinsic Signals (2011) (168)
- Fluorescence‐Activated Cell Sorting–Based Purification of Embryonic Stem Cell–Derived Neural Precursors Averts Tumor Formation after Transplantation (2006) (161)
- The role of gsc and BMP‐4 in dorsal‐ventral patterning of the marginal zone in Xenopus: a loss‐of‐function study using antisense RNA. (1995) (146)
- Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC‐Derived Neural Cells in a Primate Model of Parkinson's Disease (2012) (145)
- Bidirectional developmental potential in reprogrammed cells with acquired pluripotency (2014) (143)
- A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. (1998) (143)
- SoxD an Essential Mediator of Induction of Anterior Neural Tissues in Xenopus Embryos (1998) (138)
- Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. (2015) (133)
- Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells (2016) (126)
- Self-formation of layered neural structures in three-dimensional culture of ES cells (2012) (123)
- Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells (2010) (121)
- Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells (2015) (113)
- Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis (2006) (113)
- Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation (2008) (110)
- Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Spemann’s Organizer Signals (2013) (104)
- Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus (1995) (101)
- Generation of cerebellar neuron precursors from embryonic stem cells. (2006) (96)
- Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells (2003) (91)
- Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix. (2006) (88)
- Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. (2011) (87)
- Roles of Sox factors in neural determination: conserved signaling in evolution? (2001) (84)
- Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell‐derived inducing activity (2002) (79)
- Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. (2010) (77)
- Relaxation-expansion model for self-driven retinal morphogenesis (2012) (76)
- Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture (2012) (76)
- Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis (2015) (74)
- Generation of graftable dopaminergic neuron progenitors from mouse ES cells by a combination of coculture and neurosphere methods (2006) (65)
- Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs. (2016) (64)
- pTransgenesis: a cross-species, modular transgenesis resource (2011) (61)
- Rapid accumulation of nucleostemin in nucleolus during newt regeneration (2007) (60)
- Induction of the differentiation of lentoids from primate embryonic stem cells. (2003) (59)
- FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation (2014) (57)
- Dorsalization of the Neural Tube by Xenopus Tiarin, a Novel Patterning Factor Secreted by the Flanking Nonneural Head Ectoderm (2002) (56)
- Meningeal cells induce dopaminergic neurons from embryonic stem cells (2008) (55)
- Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis (2013) (54)
- Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline. (2000) (53)
- Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency (2014) (53)
- Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. (2004) (52)
- Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis (2018) (52)
- Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. (2005) (47)
- Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. (2010) (46)
- Ectodermal Factor Restricts Mesoderm Differentiation by Inhibiting p53 (2008) (46)
- Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling. (2004) (44)
- An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation (2005) (44)
- Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations. (2005) (41)
- Regulation of neural determination by evolutionarily conserved signals: anti-BMP factors and what next? (2001) (41)
- Emergence of dorsal-ventral polarity in ESC-derived retinal tissue (2016) (40)
- Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework (2013) (40)
- The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements (2004) (37)
- In vitro recapitulation of neural development using embryonic stem cells: From neurogenesis to histogenesis (2012) (35)
- Generation of thalamic neurons from mouse embryonic stem cells (2017) (32)
- Use of “MGE Enhancers” for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons (2013) (31)
- Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance. (2013) (30)
- Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism (2017) (30)
- Generation of dopaminergic neurons from embryonic stem cells (2002) (29)
- XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination (2007) (28)
- Collection of neural inducing factors from PA6 cells using heparin solution and their immobilization on plastic culture dishes for the induction of neurons from embryonic stem cells. (2005) (24)
- An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation. (2017) (21)
- Cultivation of Corneal Endothelial Cells on a Pericellular Matrix Prepared from Human Decidua-Derived Mesenchymal Cells (2012) (21)
- Selective neural induction from ES cells by stromal cell-derived inducing activity and its potential therapeutic application in Parkinson's disease. (2002) (21)
- Feeder-Free Generation and Long-Term Culture of Human Induced Pluripotent Stem Cells Using Pericellular Matrix of Decidua Derived Mesenchymal Cells (2013) (21)
- Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway (2010) (18)
- Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework (2016) (18)
- One-Step Induction of Neurons from Mouse Embryonic Stem Cells in Serum-Free Media Containing Vitamin B12 and Heparin (2006) (16)
- Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors (2006) (16)
- Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice (2008) (15)
- Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning. (2010) (14)
- Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue (2019) (14)
- Pericellular matrix of decidua‐derived mesenchymal cells: A potent human‐derived substrate for the maintenance culture of human ES cells (2009) (13)
- Generation of Cerebellar Neuron Precursors from Embryonic Stem Cells (2006) (11)
- Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways (2000) (10)
- Grow your own eye: biologists have coaxed cells to form a retina, a step toward growing replacement organs outside the body. (2012) (9)
- Activation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro (2015) (9)
- Establishment of Functional Genomics Pipeline in Mouse Epiblast-Like Tissue by Combining Transcriptomic Analysis and Gene Knockdown/Knockin/Knockout, Using RNA Interference and CRISPR/Cas9. (2016) (9)
- Comparative, transcriptome analysis of self-organizing optic tissues (2015) (9)
- Grow your own eye. (2012) (8)
- Essential technical tips for STAP cell conversion culture from somatic cells (2014) (8)
- Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (2008) (7)
- Directed differentiation of neural and sensory tissues from embryonic stem cells in vitro. (2005) (7)
- Bridging the gap from frog research to human therapy: A tale of neural differentiation in Xenopus animal caps and human pluripotent cells (2008) (7)
- [Human pluripotent stem cell and neural differentiation]. (2008) (7)
- Control of neural differentiation from pluripotent stem cells (2008) (6)
- Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis (2014) (6)
- Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs. (2017) (6)
- Developmental biology: A blank canvas no more (2005) (5)
- A point mutation in the 5′ splice region of intron 7 causes a deletion of exon 7 in adenosine deaminase mRNA (1993) (5)
- A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells (2017) (5)
- IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro (2016) (4)
- Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus (1995) (4)
- Retinal Pigment Epithelial Cells Differentiated from Primate Embryonic Stem Cells (2003) (3)
- The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo. (2007) (3)
- Report on STAP Cell Research Paper Investigation (2014) (3)
- [In vitro differentiation of telencephalic precursors from ES cells]. (2005) (3)
- REVIEW Ectodermal Patterning in Vertebrate Embryos (1997) (2)
- 2F16 Modeling Cell Proliferation for Simulating Tissue Morphogenesis Using Reversible Network Reconnection Model (2013) (2)
- A matter of some importins: nuclear transport factors in ES cell maintenance and differentiation. (2007) (2)
- Live-imaging of Day 10 Rx::GFP+//TOP::DsRed tissue tissue under Wnt/!-catenin or Fgf signalling stimulation. (2015) (1)
- Subregional specification of ES cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals (2011) (1)
- Induction Of Ocular Tissues From Human-induced Pluripotent Stem Cells On The Amniotic Membrane Matrix (2010) (1)
- DOWNSTREAM GENES OF NEURAL INDUCTION (1997) (0)
- Self-organized formation of cortical neural tissue from embryonic stem cells (2009) (0)
- The neural inducer chordin and its downstream genes (1998) (0)
- Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism (2017) (0)
- Induction Of Corneal Epithelial Cells From Human Embryonic Stem Cells On The Amniotic Membrane Matrix (2011) (0)
- Publisher Correction: Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue (2020) (0)
- 2P137 3D vertex model for revealing mechanics in multicellular morphogenesis(09. Development & Differentiation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) (2014) (0)
- Archaeology: One mummy but three people (2012) (0)
- J025021 Mathematical Insight into Modeling Morphological Development of Sheet-Like Multicellular Tissue (2011) (0)
- Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework (2012) (0)
- Molecular control of induction and specification of vertebrate nervous system (2000) (0)
- Nanoscale Probes and Platforms for Analysis of Gene Expression in Living RPE Cells (2012) (0)
- Publisher Correction: Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue (2020) (0)
- Rho-Signaling-Directed YA P / TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells Graphical (0)
- S021011 Reversible Network Reconnection Simulation of Effects of Apical Contractility on Curvatures of Growing Epithelia (2013) (0)
- In Brief (2014) (0)
- 3D07 In vitro experimental system for observation of cell cycles in optic-cup morphogenesis (2013) (0)
- 1SCP-02 Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Chordin(1SCP Challenges to in vivo biophysics,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan) (2013) (0)
- Climate change: Melting ice behind arctic warming (2012) (0)
- [Regulatory mechanisms of early neural development: lessons from Xenopus, mouse and primate studies]. (2002) (0)
- 8C43 Modeling cell division and growth in morphogenetic dynamics of tissue development (2012) (0)
- IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro (2016) (0)
- Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis (2012) (0)
- Differentiation of Rod and Cone Photoreceptors From Human Embryonic Stem Cells Under Defined Culture Conditions (2008) (0)
- Title Self-Formation of Optic Cups and Storable Stratified (2016) (0)
- Characterization Of Corneal Epithelial Cells Induced From Human Embryonic Stem Cells On The Amniotic Membrane Matrix (2012) (0)
- Title A RHO Small GTPase Regulator ABR Secures Mitotic Fidelityin Human Embryonic Stem Cells (2018) (0)
- Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework (2015) (0)
- GP2-7: The IGF/IGFR pathway regulates axial patterning during early neural development in mammal (2014) (0)
- Stepwise Induction of Cone- and Rod-Photoreceptor Differentiation From Mouse ES Cell-Derived Retinal Progenitors (2008) (0)
- Induction Of Corneal Epithelial Cells From Human-induced Pluripotent Stem Cells On The Amniotic Membrane Matrix (2012) (0)
- Steered differentiation and prospective selection of cerebellar Purkinje cells in the ES cell culture system (2010) (0)
- 1PT219 Simulations of large deformation during tissue morphogenesis using reversible network reconnection model(The 50th Annual Meeting of the Biophysical Society of Japan) (2012) (0)
- Eye Drops Of Small Molecular Weight Inhibitor SRPIN340, Target SRPK1/2 To Control VEGF Mediated Choroidal Neovascularisation (2012) (0)
- Transplantation of human induced pluripotent stem cell-derived retinal tissue in primate models of retinal degeneration with perimetric analysis (2016) (0)
- Electrophysiological Evaluation of Mouse ES and iPS Derived Retina-like Sheet Transplantation in Retinal Degeneration Mouse (2012) (0)
- Procédé de culture de cellule souche (2009) (0)
- Self-organization of neural patterns and structures in 3D culture of stem cells (2013) (0)
- Activation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro (2015) (0)
- Regulatory mechanisms of neural differentiation from pluripotent cells (2007) (0)
- Title Vulnerability of Purkinje Cells Generated from SpinocerebellarAtaxia Type 6 Patient-Derived iPSCs (2018) (0)
- Summary An essential role of Xenopus Foxi 1 a for ventral specification of the cephalic ectoderm during gastrulation (2005) (0)
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