Yue Xiong
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Yue Xiongcomputer-science Degrees
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Engineering Computer Science
Yue Xiong's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Computer Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Yue Xiong's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- p21 is a universal inhibitor of cyclin kinases (1993) (3614)
- Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. (2011) (2310)
- ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways (1998) (1732)
- Regulation of Cellular Metabolism by Protein Lysine Acetylation (2010) (1646)
- Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters (2011) (1066)
- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α (2009) (1053)
- D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA (1992) (1047)
- Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux (2010) (929)
- TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway (2008) (857)
- Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. (2012) (811)
- BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase (2005) (682)
- Human D-type cyclin (1991) (682)
- Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway (2003) (578)
- Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation (2013) (526)
- Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (2006) (524)
- TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition* (2009) (497)
- Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. (2011) (495)
- ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (1999) (487)
- Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS (2011) (483)
- Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases (2003) (436)
- The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase* (2010) (428)
- CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. (1998) (425)
- A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation (2001) (410)
- Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. (2005) (390)
- Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. (1999) (371)
- Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage (2004) (358)
- CRL4s: the CUL4-RING E3 ubiquitin ligases. (2009) (355)
- Mutations in Isocitrate Dehydrogenase 1 and 2 Occur Frequently in Intrahepatic Cholangiocarcinomas and Share Hypermethylation Targets with Glioblastomas (2012) (345)
- pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. (2007) (335)
- Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. (2011) (332)
- NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. (2002) (330)
- DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. (2006) (319)
- Regulation of intermediary metabolism by protein acetylation. (2011) (316)
- IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives (2012) (310)
- Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases (2004) (293)
- Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity (2000) (290)
- Signaling pathways that control cell proliferation. (2013) (278)
- Nutrient sensing, metabolism, and cell growth control. (2013) (276)
- Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. (2013) (267)
- Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15INK4B through an Sp1 Consensus Site (*) (1995) (267)
- Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. (2013) (250)
- WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. (2015) (246)
- Characterization of Arabidopsis and Rice DWD Proteins and Their Roles as Substrate Receptors for CUL4-RING E3 Ubiquitin Ligases[W] (2008) (235)
- Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress (2014) (228)
- Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. (2013) (224)
- Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase (*) (1995) (210)
- Mechanistic insights into the regulation of metabolic enzymes by acetylation (2012) (203)
- Control of p53 ubiquitination and nuclear export by MDM2 and ARF. (2001) (203)
- Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication. (2016) (197)
- A Role for NF-κB Essential Modifier/IκB Kinase-γ (NEMO/IKKγ) Ubiquitination in the Activation of the IκB Kinase Complex by Tumor Necrosis Factor-α* (2003) (190)
- Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues (2005) (173)
- Estrogen regulates Hippo signaling via GPER in breast cancer. (2015) (173)
- SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense (2016) (171)
- Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. (1997) (171)
- Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. (1998) (162)
- WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (2008) (156)
- A role for NEMO/IKKγ Ubiquitination in the activation of the IκB kinase complex by TNF-α (2003) (151)
- The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition* (2012) (150)
- Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation. (1996) (148)
- HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin (1999) (145)
- SIRT3‐dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth (2015) (144)
- Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (1998) (143)
- SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer (2018) (142)
- Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. (2015) (141)
- Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. (2017) (139)
- Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes[W] (2008) (139)
- The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1 (2000) (138)
- Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates (2018) (137)
- Advancing targeted protein degradation for cancer therapy (2021) (137)
- Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). (2018) (136)
- Arabidopsis CAND1, an Unmodified CUL1-Interacting Protein, Is Involved in Multiple Developmental Pathways Controlled by Ubiquitin/Proteasome-Mediated Protein Degradation (2004) (132)
- PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ* (2010) (132)
- An Evolutionarily Conserved Function of Proliferating Cell Nuclear Antigen for Cdt1 Degradation by the Cul4-Ddb1 Ubiquitin Ligase in Response to DNA Damage* (2006) (126)
- NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. (2014) (124)
- Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. (1998) (124)
- Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis (2003) (120)
- CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. (2002) (119)
- Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins (1998) (111)
- Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis (2018) (111)
- Alterations of metabolic genes and metabolites in cancer. (2012) (108)
- Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. (2014) (108)
- p15PAF, a novel PCNA associated factor with increased expression in tumor tissues (2001) (107)
- Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. (2012) (106)
- A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. (2003) (104)
- X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. (2011) (100)
- Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma (2017) (98)
- Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. (2019) (97)
- Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides (2010) (96)
- Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function (2006) (95)
- Coupled Transcriptional and Translational Control of Cyclin-Dependent Kinase Inhibitor p18INK4cExpression during Myogenesis (1998) (95)
- Activation of UBC5 Ubiquitin-conjugating Enzyme by the RING Finger of ROC1 and Assembly of Active Ubiquitin Ligases by All Cullins* (2002) (91)
- Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK. (2011) (91)
- CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. (2009) (90)
- CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. (2015) (89)
- Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity (2020) (86)
- 14-3-3β Binds to and Negatively Regulates the Tuberous Sclerosis Complex 2 (TSC2) Tumor Suppressor Gene Product, Tuberin* (2003) (82)
- HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. (1999) (79)
- R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. (2013) (78)
- Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-molecule Degraders. (2020) (77)
- Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development (2008) (70)
- Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration* (2016) (70)
- G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L (2015) (70)
- Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. (2007) (69)
- Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. (2005) (69)
- Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt (2019) (68)
- Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal* (2013) (68)
- Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases. (2001) (67)
- Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. (2016) (66)
- DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. (2009) (66)
- Regulation of cyclin-dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1. (1998) (66)
- Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. (2015) (65)
- An Important Role of CDK Inhibitor p18INK4c in Modulating Antigen Receptor-Mediated T Cell Proliferation1 (2001) (65)
- The 3M complex maintains microtubule and genome integrity. (2014) (63)
- p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors (2006) (63)
- Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication. (2018) (63)
- Human tumor suppressor ARF impedes S-phase progression independent of p53. (2002) (63)
- Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1 (2015) (61)
- Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. (2017) (61)
- Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation. (2013) (58)
- CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. (2014) (56)
- Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals* (2009) (55)
- Association with cullin partners protects ROC proteins from proteasome-dependent degradation (1999) (55)
- Intragenic mutations of the p16INK4, p15INK4B and p18 genes in primary non‐small‐cell lung cancers (1996) (54)
- The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells (2014) (54)
- SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response (2018) (53)
- D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth (2015) (53)
- A Role for Saccharomyces cerevisiae Cul8 Ubiquitin Ligase in Proper Anaphase Progression* (2003) (52)
- Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. (1995) (52)
- CRL4A-FBXW5–mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth (2013) (51)
- Ectromelia Virus Encodes a Novel Family of F-Box Proteins That Interact with the SCF Complex (2008) (49)
- Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. (2011) (48)
- PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction (2015) (48)
- A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues (2016) (48)
- Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. (1995) (48)
- Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases. (2008) (48)
- Parathyroid Tumor Suppressor on 1p: Analysis of the p18 Cyclin‐Dependent Kinase Inhibitor Gene As a Candidate (1997) (47)
- Molecular analysis of the cyclin‐dependent kinase inhibitor genes p15INK4b/MTS21, p16INK4/MTS1, p18 and pl9 in human cancer cell lines (1996) (47)
- Population explosion in the cyclin family (1991) (46)
- DDB 1 functions as a linker to recruit receptor WD 40 proteins to CUL 4 – ROC 1 ubiquitin ligases (2006) (46)
- TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites (2014) (46)
- Genetic Evidence for Functional Dependency of p18Ink4c on Cdk4 (2004) (45)
- CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. (2017) (45)
- p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. (2007) (44)
- Assay for activity of mammalian cyclin D-dependent kinases CDK4 and CDK6. (1997) (43)
- p18Ink4c and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control (2006) (43)
- p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. (2011) (41)
- Why are there so many CDK inhibitors? (1996) (41)
- VprBP binds full‐length RAG1 and is required for B‐cell development and V(D)J recombination fidelity (2012) (41)
- Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma (1995) (39)
- Variants in CUL4B are Associated with Cerebral Malformations (2015) (38)
- p18(INK4c) collaborates with other CDK‐inhibitory proteins in the regenerating liver (2003) (37)
- Immunoprecipitation and Immunoblotting in Cell Cycle Studies (1996) (37)
- IDH 1 and IDH 2 Mutations in Tumorigenesis : Mechanistic Insights and Clinical Perspectives (2012) (36)
- SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress (2019) (35)
- Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system (2017) (35)
- p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. (2006) (35)
- KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation (2015) (34)
- Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail (2011) (34)
- Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. (1999) (31)
- CDK inhibitors p18 and p27 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis (1998) (31)
- The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis (2019) (31)
- The mechanisms of IDH mutations in tumorigenesis (2012) (30)
- Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses (2021) (27)
- A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. (2015) (27)
- Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. (2012) (27)
- USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2 (2020) (26)
- Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors. (1996) (24)
- Assays for RING family ubiquitin ligases. (2005) (24)
- Effects of DNAzymes targeting Aurora kinase A on the growth of human prostate cancer (2008) (24)
- L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration (2017) (24)
- The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase (2016) (24)
- Regulation of G 6 PD acetylation by SIRT 2 and KAT 9 modulates NADPH homeostasis and cell survival during oxidative stress # (2014) (23)
- Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. (2022) (22)
- Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila (2015) (21)
- DCAF1 controls T-cell function via p53-dependent and -independent mechanisms (2016) (21)
- Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers. (1996) (20)
- Control of p 53 Ubiquitination and Nuclear Export by MDM 2 and ARF 1 (2001) (20)
- LDH-A Acetylation: Implication in Cancer (2013) (19)
- Acetylation control of cancer cell metabolism. (2014) (19)
- Recruiting Substrates to Cullin 4-Dependent Ubiquitin Ligases by DDB1 (2005) (19)
- Cell Type–dependent Requirement for PIP Box–regulated Cdt1 Destruction During S Phase (2010) (17)
- Metabolic alteration in tumorigenesis (2013) (17)
- Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network (2020) (17)
- Biochemical Characterization of the Human Cyclin-dependent Protein Kinase Activating Kinase (1996) (17)
- Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53 (2017) (16)
- No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus. (2006) (15)
- T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. (1998) (15)
- The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. (2020) (14)
- Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry (2018) (14)
- Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1 (2015) (13)
- DDB 1-CUL 4 and MLL 1 Mediate Oncogene-Induced p 16 INK 4 a Activation (2009) (12)
- SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes (2017) (12)
- Decoding Ci: From partial degradation to inhibition (2015) (12)
- Expression of p 16 Ink 4 a Compensates for p 18 Ink 4 c Loss in Cyclin-Dependent Kinase 4 / 6 – Dependent Tumors and Tissues (2007) (11)
- Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination (2016) (11)
- S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-κB signaling pathway in mice. (2019) (10)
- Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. (2019) (10)
- Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-κB signaling pathways. (2021) (10)
- Targeting protein ubiquitylation: DDB1 takes its RING off (2009) (10)
- CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. (2020) (9)
- UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing (2017) (9)
- Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. (2015) (8)
- Tumour metabolites hinder DNA repair (2020) (8)
- Cytoplasmic CUL 9 / PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p 53-Dependent Apoptosis (2011) (7)
- Faculty Opinions recommendation of p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo. (2002) (6)
- Targeting p21 degradation locally. (2010) (6)
- Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance (2022) (6)
- The antiobesity factor WDTC 1 suppresses adipogenesis via the CRL 4 WDTC 1 E 3 ligase (2016) (5)
- Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. (2022) (5)
- FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway (2021) (5)
- Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus (2011) (5)
- ELP3 acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). (2019) (5)
- Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity (2022) (5)
- TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner (2022) (5)
- Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (2019) (5)
- SNIP 1 Recruits TET 2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response (2019) (5)
- Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis (2022) (5)
- Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas (2012) (4)
- Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription (2016) (4)
- Purification and crystallization of cyclin‐dependent kinase inhibitor p21 (1996) (4)
- Targeted ubiquitylation: the prey becomes predator. (2010) (4)
- Regulation of G 6 PD acetylation by KAT 9 / SIRT 2 modulates NADPH homeostasis and cell survival during oxidative stress (2014) (4)
- Out of the F-box: reawakening the pancreas. (2014) (4)
- PARD 3 induces TAZ activation and cell growth by promoting LATS 1 and PP 1 interaction (2015) (4)
- Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras. (2022) (4)
- CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML (2021) (3)
- Cancer: Suffocation of gene expression (2016) (3)
- Extensive and choreographed transcription of noncoding RNAs within cell cycle promoters (2010) (3)
- p18 and Pten Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control (2006) (2)
- Advances in Brief Mutations in the p 16 @ ' @ 4 / MTS 1 / CDKN 2 , p 15 @ 4 B / MTS 2 , and p 18 Genes in Primary and Metastatic Lung Cancer ' (2006) (2)
- An MDM2 degrader for treatment of acute leukemias (2021) (2)
- Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated. (2006) (2)
- Cell Cycle Control Regulatory Loop between Cell Growth and Constrain a Positive Pten and Ink4c p18 (2014) (2)
- Sqh is involved in the regulation of Ci stability in Hh signaling pathway. (2015) (2)
- A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. (2022) (2)
- Polycomb repression complexes binding to and silencing p 16 pRB family proteins are required for H 3 K 27 trimethylation and (2006) (2)
- SDH tumor suppressors fumarate and succinate that are accumulated in mutations of FH-KG-dependent histone and DNA demethylases by α Inhibition of Material Supplemental (2012) (2)
- Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex (2022) (2)
- Advancing targeted protein degradation for cancer therapy (2021) (1)
- p18 Ink4c , but Not p27 Kip1 , Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors (cid:1) (2007) (1)
- G-protein-coupled receptors regulate autophagy by ZBTB 16-mediated ubiquitination and proteasomal degradation of Atg 14 (2015) (1)
- Crystal Structure of The Cand1-Cul1-Roc1 Complex (2004) (1)
- Acetylation Regulation of Cellular Metabolism by Protein Lysine (2010) (1)
- A mosaic analysis system with Cre or Tomato expression in the mouse (2020) (1)
- Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. (2019) (1)
- tumor suppressor gene INK4arepression complexes binding to and silencing p16 pRB family proteins are required for H3K27 trimethylation and (2007) (1)
- Repression ofCyclin Dl:aNovelFunction ofMYC (1994) (1)
- FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway (2021) (1)
- ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3 (2022) (1)
- Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET. (2015) (1)
- P08.65 The mechanisms of oncometabolites in epigenetic control, DNA repair, neural development and gliomagenesis (2017) (1)
- Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis (2018) (0)
- p16 Family Inhibitors of Cyclin-Dependent Kinases (1996) (0)
- Corrigendum (2022) (0)
- Role of Rho-like proteins of the RhoBTB family in oncogenesis (2004) (0)
- Receptor-Mediated T Cell Proliferation in Modulating Antigen INK4cAn Important Role of CDK Inhibitor p18 (2001) (0)
- Tumour metabolites hinder DNA repair (2020) (0)
- Rearrangement of the cyclin komlexes and his related applications (1993) (0)
- Atypical Rho GTPases the RhoBTB family: role as adaptors of ubiquitin ligase complexes (2008) (0)
- Identification of essential functional elements of pls!nk4c (1998) (0)
- Proteolysis Targeting Chimaeras Induce the Degradation of Epidermal Growth Factor Receptor in Lung Cancer (2020) (0)
- Abstract SY38-04: Altered metabolic enzymes and metabolites in cancer (2012) (0)
- Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation (2022) (0)
- Cooperation of p18INK4c with p21CIP1/WAF1 and p27KIP1 in liver-regeneration (2002) (0)
- X-Linked Mental Retardation Gene Product CUL4B Targets Ubiquitylation of H3K4 Methyltransferase Core Component WDR5 and Regulates Neuronal Gene Expression (2011) (0)
- Metabolic alteration in tumorigenesis (2013) (0)
- Control of thymocyte proliferation and thymus organ size by CDK inhibitors P18INK4c and P27KIP1 (2006) (0)
- Evaluation of the Expanding Quality of Life in Chinese Population (2018) (0)
- G1 Cell Cycle Control by Regulated Proteolysis in Normal and Tumorigenic Breast Cells (2002) (0)
- TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. (2022) (0)
- The Cullin‐ROC familyof E3 Ubiquitin Ligases (2008) (0)
- Award Number : DAMD 1799-1-9574 TITLE : Gl Cell Cycle Control by Regulated Proteolysis in Normal and Tumorigenic Breast Cells (0)
- HIV-1 Vpr Degrades TET2 to Suppress IRF7 and Interferon Expression in Plasmacytoid Dendritic Cells (2019) (0)
- Advances in Brief Phosphorylation-and SKP 1-independent in Vitro Ubiquitination of E 2 F 1 by Multiple ROC-Cullin Ligases 1 (2001) (0)
- Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development (cid:1) (2008) (0)
- Phosphoglycerate Mutase Oxidative Stress Activates SIRT 2 to Deacetylate and Stimulate (2014) (0)
- BbRAGL-3'TIR synaptic complex with nicked DNA refined with C2 symmetry (2019) (0)
- Suppression of Prostate Tumors by INK4C and PTEN (2007) (0)
- LDH-A Enzyme Assay (2013) (0)
- Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy (2023) (0)
- Isolation of Proteins Interacting With the Cyclin D1-CDK6 Complex From Normal and Tumorigenic Human Breast Cells Using a Novel Yeast Three-Hybrid System (1999) (0)
- Rearrangement of cyklinkomplekser and uses related thereto (1993) (0)
- No exit strategy? No problem: APC inhibits (cid:1) -catenin inside the nucleus (2006) (0)
- The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response (2023) (0)
- Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal Tumorigenic Human Breast Cells (2001) (0)
- Correction for Kim et al., “Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail” (2017) (0)
- Qijun Wang Utilization and Metabolic Flux Acetylation of Metabolic Enzymes Coordinates Carbon Source (2014) (0)
- p16 and ARF: Crossroads of Tumorigenesis (2002) (0)
- Assessment and Comparison of EQ-5D-3L, EQ-5D-5L and Icecap-A Index Scores in the General and Specific Groups of Chinese Population (2018) (0)
- Supplemental Information Deubiquitination of Ci / Gli by Usp 7 / HAUSP regulates Hedgehog Signaling (2015) (0)
- Abstract 5177: SIRT2 deacetylates and activates glucose-6-phosphate dehydrogenase (G6PD) to protect cells against oxidative stress. (2013) (0)
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