Yukiko Gotoh
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Computer Science
Yukiko Gotoh's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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Why Is Yukiko Gotoh Influential?
(Suggest an Edit or Addition)Yukiko Gotoh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery (1997) (5977)
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways (1997) (2262)
- Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase (1995) (2039)
- The MAP kinase cascade is essential for diverse signal transduction pathways. (1993) (1060)
- Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53* (2002) (608)
- JNK promotes Bax translocation to mitochondria through phosphorylation of 14‐3‐3 proteins (2004) (555)
- TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction (1996) (521)
- A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3* (1996) (493)
- β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand (2001) (486)
- Activation and Involvement of p38 Mitogen-activated Protein Kinase in Glutamate-induced Apoptosis in Rat Cerebellar Granule Cells* (1997) (445)
- Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling (2004) (428)
- Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition (2009) (418)
- The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells (2004) (415)
- Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase (1997) (396)
- Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1 (1998) (395)
- In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase (1991) (388)
- A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C (1993) (383)
- The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria* (2002) (367)
- TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase* (1997) (348)
- Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal* (1996) (344)
- JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3 (2005) (344)
- Epigenetic control of neural precursor cell fate during development (2010) (341)
- Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells. (1990) (333)
- Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction* (1998) (327)
- Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. (1994) (297)
- Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade (2003) (287)
- Microtubule severing by elongation factor 1 alpha. (1994) (264)
- A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses (1997) (261)
- Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells (2015) (254)
- Role of TAK1 and TAB1 in BMP signaling in early Xenopus development (1998) (248)
- Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. (1991) (242)
- β‐Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone (2007) (234)
- SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling (2002) (227)
- Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions* (2003) (218)
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (1996) (216)
- The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway (1996) (213)
- Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells. (1994) (211)
- Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation. (1994) (208)
- Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade. (1992) (206)
- Scaffolding function of PAK in the PDK1–Akt pathway (2008) (201)
- Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. (1992) (196)
- Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. (2003) (184)
- A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade (1997) (184)
- Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade (*) (1995) (178)
- Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells (2001) (176)
- Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers (2018) (175)
- Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation (2001) (162)
- Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis* (2001) (156)
- Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. (2003) (156)
- Induction of neurite outgrowth by MAP kinase in PC12 cells. (1995) (156)
- Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. (1994) (155)
- Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells (1996) (155)
- cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. (1993) (154)
- Involvement of the MAP kinase cascade in Xenopus mesoderm induction. (1995) (152)
- Activation of Protein Kinase Cascades by Osmotic Shock (*) (1995) (152)
- Both Phosphorylation and Caspase-mediated Cleavage Contribute to Regulation of the Ste20-like Protein Kinase Mst1 during CD95/Fas-induced Apoptosis* (2001) (145)
- Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. (1998) (145)
- p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis (2013) (143)
- Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase (2004) (137)
- MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression* (2001) (134)
- Stage-dependent fate determination of neural precursor cells in mouse forebrain (2005) (133)
- Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases. (1995) (127)
- Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex (2006) (125)
- Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity* (2003) (124)
- Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-associated protein 4, induces an alteration in their function. (1992) (123)
- Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition–like mechanism (2013) (119)
- Regulation of a major microtubule‐associated protein by MPF and MAP kinase. (1992) (116)
- Mitogen-Activated Protein Kinase (2020) (116)
- HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells (2012) (116)
- MST1‐JNK promotes apoptosis via caspase‐dependent and independent pathways (2001) (115)
- Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis (2013) (111)
- MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts (1997) (110)
- REGULATION OF THE CELL SURFACE EXPRESSION OF HUMAN BCRP/ABCG2 BY THE PHOSPHORYLATION STATE OF AKT IN POLARIZED CELLS (2005) (105)
- The Cyclin-dependent Kinase Inhibitors p57 and p27 Regulate Neuronal Migration in the Developing Mouse Neocortex* (2007) (103)
- Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. (1994) (103)
- Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase. (1993) (100)
- Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells (1996) (100)
- The Sox-2 Regulatory Regions Display Their Activities in Two Distinct Types of Multipotent Stem Cells (2004) (96)
- Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis. (2004) (96)
- Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex (2010) (95)
- Mitogen-activated protein kinase kinase is required for the mos-induced metaphase arrest. (1994) (94)
- Activation of the c-Jun N-Terminal Kinase Pathway by MST1 Is Essential and Sufficient for the Induction of Chromatin Condensation during Apoptosis (2007) (89)
- Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. (1994) (88)
- The PI3K‐Akt pathway promotes microtubule stabilization in migrating fibroblasts (2007) (87)
- α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2 (2011) (87)
- Activation mechanism and function of the MAP kinase cascade (1995) (83)
- Zbtb20 promotes astrocytogenesis during neocortical development (2016) (83)
- Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon (2008) (78)
- Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells. (1990) (76)
- Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs: involvement of phosphorylation and accumulation of pericentriolar material. (1993) (71)
- Requirement for Mitogen-activated Protein Kinase in Cerebellar Long Term Depression* (1999) (69)
- Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system. (1992) (67)
- Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. (2006) (67)
- Mechanisms that regulate the number of neurons during mouse neocortical development (2010) (67)
- Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1 (2009) (64)
- A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development (2012) (64)
- Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. (1991) (63)
- Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites. (1994) (61)
- Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase (1993) (61)
- The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development (2014) (59)
- Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection. (1992) (59)
- Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. (2004) (57)
- Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone (2017) (57)
- Roles of the MAP kinase cascade in vertebrates. (1996) (57)
- The phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells (2003) (56)
- Tcf3 Represses Wnt–β-Catenin Signaling and Maintains Neural Stem Cell Population during Neocortical Development (2014) (53)
- A novel homo‐oligomeric protein responsible for an MPF‐dependent microtubule‐severing activity. (1992) (53)
- Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex. (2018) (53)
- Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. (1996) (46)
- NEDDylation controls the target specificity of E2F1 and apoptosis induction (2013) (42)
- PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex (2016) (39)
- Mitogen-activated protein kinase and cytoskeleton in mitogenic signal transduction. (1992) (38)
- IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells (2013) (38)
- Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells (2013) (37)
- A mitogen-activated protein (MAP) kinase activating factor in mammalian mitogen-stimulated cells is homologous to Xenopus M phase MAP kinase activator. (1992) (37)
- Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. (1996) (34)
- Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells. (2004) (32)
- Regulation and function of the MAP kinase cascade in Xenopus oocytes (1994) (31)
- Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway (2019) (31)
- Chromatin regulators of neural development (2014) (30)
- The MAP kinase cascade: its role in Xenopus oocytes, eggs and embryos. (1995) (28)
- Mineralization induced by beta-glycerophosphate in cultures leads to a marked increase in collagenase synthesis by mouse osteogenic MC3T3-E1 cells under subsequent stimulation with heparin. (1989) (28)
- Signaling pathways mediated by the mitogen‐activated protein (MAP) kinase kinase/MAP kinase cascade (1994) (27)
- Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities. (2020) (27)
- Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor. (1995) (26)
- Regulation of Chromatin Structure During Neural Development (2018) (26)
- High Mobility Group Nucleosome‐Binding Family Proteins Promote Astrocyte Differentiation of Neural Precursor Cells (2014) (24)
- Epidermal Growth Factor Signaling Mediated by Grb2 Associated Binder1 Is Required for the Spatiotemporally Regulated Proliferation of Olig2‐Expressing Progenitors in the Embryonic Spinal Cord (2007) (23)
- The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response (2015) (23)
- Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes. (1994) (22)
- JNK phosphorylates synaptotagmin‐4 and enhances Ca2+‐evoked release (2008) (22)
- Activation of a serine/threonine kinase that phosphorylates microtubule-associated protein 1B in vitro by growth factors and phorbol esters in quiescent rat fibroblastic cells. (1990) (19)
- Microtubule-severing activity in M phase. (1995) (19)
- Transcriptional coupling of neuronal fate commitment and the onset of migration (2013) (18)
- Signals for mesoderm induction. Roles of fibroblast growth factor (FGF)/mitogen-activated protein kinase (MAPK) pathway. (1996) (17)
- Isolation and characterization of neutralizing single-chain antibodies against Xenopus mitogen-activated protein kinase kinase from phage display libraries. (1996) (15)
- Plag1 regulates neuronal gene expression and neuronal differentiation of neocortical neural progenitor cells (2019) (14)
- Up‐regulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex (2015) (14)
- The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon (2019) (13)
- Diverse gene regulatory mechanisms mediated by Polycomb group proteins during neural development (2019) (12)
- Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development (2020) (11)
- Summary The Wnt / β-catenin pathway directs neuronal differentiation of cortical neural precursor cells (2004) (11)
- The PI 3 K-Akt pathway suppresses Bax translocation to mitochondria (2002) (10)
- Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module (2021) (10)
- PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development (2012) (10)
- Mitochondrial localization of the antiviral signaling adaptor IPS‐1 is important for its induction of caspase activation (2013) (9)
- Transcriptional activation of mouse major satellite regions during neuronal differentiation. (2012) (9)
- Multiple roles of the mitogen‐activated protein kinase kinase/mitogen‐activated protein kinase cascade in Xenopus laevis (1996) (7)
- Retraction Note: Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade (2014) (6)
- Adenosine A 2 A Receptor Facilitates Calcium-Dependent Protein Secretion through the Activation of Protein Kinase A and Phosphatidylinositol-3 Kinase in PC 12 Cells (2005) (6)
- Purification and Identification of a Major Activator for p38 from Osmotically Shocked Cells ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 BY OSMOTIC SHOCK, TUMOR NECROSIS FACTOR-a, AND H2O2* (1996) (5)
- Isolation of genetically manipulated neural progenitors and immature neurons from embryonic mouse neocortex by FACS (2021) (4)
- BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors (2021) (4)
- Maintenance of neural stem‐progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon (2021) (4)
- [MAP kinase kinase/MAP kinase cascade]. (1993) (3)
- Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons. (2021) (2)
- [Role of the JNK signaling pathway]. (2008) (2)
- NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense (2020) (2)
- In utero gene transfer system for embryos before neural tube closure reveals a role for Hmga2 in the onset of neurogenesis (2020) (1)
- [The MAP kinase cascade]. (1994) (1)
- A role for Hmga2 in the early-stage transition of neural stem-progenitor cell properties during mouse neocortical development (2020) (1)
- Heterogeneity of astrocytes in the mouse neocortex (2016) (1)
- An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance. (2018) (1)
- Three-dimensional chromatin architecture of early-stage mouse embryos reconstructed via recurrence plots (2021) (1)
- [Functions of MAP kinase in cell cycle regulation]. (1996) (0)
- Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers (2018) (0)
- Endfoot regrowth for neural stem cell renewal (2019) (0)
- Activation of Mitogen-activated Protein Kinase and Its Activator by rut ? in Intact Cells and in a Cell-free System (2001) (0)
- Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis (2018) (0)
- Signalling in pattern recognition (WS-057) Chairpersons: Taro Kawai, Atsushi Matsuzawa (2010) (0)
- BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors (2021) (0)
- Chromatin-level regulation of neural stem/progenitor cell fate (2019) (0)
- Molecular mechanisms of neuronal survival; Roles of kinases in ischemic cell death (2002) (0)
- Role of the imprinted allele of the p57Kip2 gene in mouse neocortical development (2019) (0)
- Regulation of thalamocortical connection by polycomb group proteins (2017) (0)
- [Embryonic origin of adult neural stem cells]. (2016) (0)
- α2-chimaerin regulates laminar positioning in the cerebral cortex (2010) (0)
- The role of p57 imprinted allele in mouse neocortical development (2016) (0)
- XenopusM phaseMAP kinase: isolation ofitscDNA andactivation byMPF (1991) (0)
- [The MAP kinase cascade]. (1997) (0)
- Fate Regulation of Mouse Neocortical Neural Precursor Cells (2006) (0)
- [The role of lncRNA in regulation of neural stem cell fate.] (2017) (0)
- Analysis of histone modifications in mouse neocortical neural progenitor-stem cells at various developmental stages (2021) (0)
- Functions of the p57 imprinted allele in mouse neocortical development (2017) (0)
- Roles of lysosomes in embryonic neural stem/progenitor cells (2017) (0)
- Fate regulation of mouse telencephalic neural precursor cells (2006) (0)
- Temporal regulation of neural stem cell fate in the developing mouse neocortex (2010) (0)
- IL2 Neural stem cell regulation and brain development (2021) (0)
- Roles of the CDK inhibitor p57 in regulating embryonic origin of adult neural stem cells (2015) (0)
- INVOLVEMENT OF CELLULAR REDOX STATE IN CELL SURVIVAL AND NEURONAL DIFFERENTIATION IN PC12 CELLS (1996) (0)
- Involvement oftheMAP kinase cascade inXenopus mesoderminduction (1995) (0)
- Schizosaccharomyces pombeSpklisaTyrosine- Phosphorylated Protein Functionally Related toXenopus Mitogen-Activated (1993) (0)
- a2-chimaerin regulates crmp-2 activity to control cortical neuronal migration (2011) (0)
- Effects of maternal starvation on the formation of adult neural stem cells (2015) (0)
- Searching New Functions of Peroxisomes (2015) (0)
- [New development in study of intra-cellular signaling--introduction]. (2008) (0)
- Neurexin nanoclusters: A novel structure at presynaptic terminals (2019) (0)
- Signaling pathways and functions of the MAP kinase cascades (1996) (0)
- Vitamin K-dependent γ-glutamyl carboxylase (GGCX) switches IPS1-mediated immune responses and protects against viral infection of the central nervous system (2017) (0)
- protein kinase C . homolog ( Mpk 1 p ) mediates signalling by A yeast mitogen-activated protein kinase (0)
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Yukiko Gotoh is affiliated with the following schools: