Yusuf A. Hannun
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Yusuf A. Hannun's Degrees
- PhD Computer Science Stanford University
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(Suggest an Edit or Addition)According to Wikipedia, Yusuf Awni Hannun is an American molecular biologist, biochemist, and clinician. He is known for the discovery that sphingolipids have signaling functions. Early life Yusuf Awni Hannun was born in Saudi Arabia of Palestinian parents, Mrs. Aida Ashur-Hannun and Dr. Awni Hannun. He received his early education in Beirut at the International College and earned a Bachelor of Science at the American University of Beirut in 1977. Following his undergraduate degree, Hannun continued at the American University of Beirut, obtaining an MD with distinction in 1981 and completing his internship and a residency in internal medicine
Yusuf A. Hannun's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Principles of bioactive lipid signalling: lessons from sphingolipids (2008) (2845)
- Functions of Ceramide in Coordinating Cellular Responses to Stress (1996) (1616)
- Biologically active sphingolipids in cancer pathogenesis and treatment (2004) (1192)
- Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. (1989) (1129)
- Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. (1986) (977)
- The sphingomyelin cycle and the second messenger function of ceramide. (1994) (955)
- Sphingolipids and their metabolism in physiology and disease (2017) (912)
- The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind* (2002) (871)
- An overview of sphingolipid metabolism: from synthesis to breakdown. (2010) (799)
- Ceramide in apoptosis: an overview and current perspectives. (2002) (776)
- Ceramide activates heterotrimeric protein phosphatase 2A. (1993) (632)
- The complex life of simple sphingolipids (2004) (614)
- Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. (1994) (609)
- Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. (1989) (585)
- Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. (2006) (516)
- EpCAM Is Overexpressed in Breast Cancer and Is a Potential Target for Breast Cancer Gene Therapy (2004) (516)
- The sphingolipid salvage pathway in ceramide metabolism and signaling. (2008) (514)
- Substantial contribution of extrinsic risk factors to cancer development (2015) (501)
- Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3 (1997) (493)
- Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. (1987) (488)
- Role for Ceramide in Cell Cycle Arrest (*) (1995) (486)
- Role of phospholipases in generating lipid second messengers in signal transduction 1 (1991) (455)
- Tissue and cellular distribution of the extended family of protein kinase C isoenzymes (1992) (429)
- Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. (1990) (419)
- Ceramide synthases at the centre of sphingolipid metabolism and biology. (2012) (403)
- Bioactive sphingolipids: metabolism and function This work was supported by National Institutes of Health Grants GM-43825 and CA-87584. Published, JLR Papers in Press, November 17, 2008. (2009) (395)
- Ceramide Activates the Stress-activated Protein Kinases (*) (1995) (379)
- Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide (2007) (377)
- Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. (1985) (374)
- Ceramide stimulates a cytosolic protein phosphatase. (1992) (373)
- Many Ceramides* (2011) (365)
- Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death* (1998) (351)
- De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells (2002) (337)
- Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2* (2004) (336)
- Acid and neutral sphingomyelinases: roles and mechanisms of regulation. (2004) (328)
- The role of ceramide in cell signaling. (1998) (326)
- Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. (2001) (325)
- Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione* (1997) (309)
- Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A (1999) (308)
- PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane (2002) (308)
- The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE2 production in response to TNF‐α (2003) (300)
- Sphingosine kinase: biochemical and cellular regulation and role in disease. (2006) (294)
- Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae * (1997) (291)
- Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. (2009) (288)
- Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis* (2000) (285)
- Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase* (2002) (281)
- Sphingomyelin Synthase, a Potential Regulator of Intracellular Levels of Ceramide and Diacylglycerol during SV40 Transformation (1998) (276)
- Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. (1993) (270)
- Role for sphingosine kinase 1 in colon carcinogenesis (2009) (263)
- Ceramide Inactivates Cellular Protein Kinase Cα* (1996) (262)
- Ceramide and apoptosis. (1999) (261)
- Altered Adipose and Plasma Sphingolipid Metabolism in Obesity (2006) (259)
- Blood sphingolipidomics in healthy humans: impact of sample collection methodology (2010) (256)
- Roles and regulation of secretory and lysosomal acid sphingomyelinase. (2009) (256)
- Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. (1986) (252)
- Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase* (2000) (247)
- Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis (2001) (243)
- The BST1 Gene of Saccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase* (1997) (236)
- Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. (1995) (234)
- Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. (1989) (230)
- Ceramide: A stress signal and mediator of growth suppression and apoptosis (1995) (224)
- Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways (2010) (223)
- Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. (1997) (222)
- Neurotrophins Induce Sphingomyelin Hydrolysis (1995) (219)
- Sphingosine kinase 1 is up‐regulated in colon carcinogenesis (2006) (213)
- Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α* (2005) (213)
- Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. (2014) (213)
- Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway (1997) (212)
- Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release* (2003) (212)
- Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas* (2004) (206)
- (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase (*) (1996) (204)
- Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. (2013) (202)
- Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. (1993) (201)
- Plant sphingolipids: decoding the enigma of the Sphinx. (2010) (191)
- Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. (1994) (191)
- Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line (2002) (190)
- Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. (1986) (190)
- Phosphorylation Specificities of Protein Kinase C Isozymes for Bovine Cardiac Troponin I and Troponin T and Sites within These Proteins and Regulation of Myofilament Properties* (1996) (185)
- A role for sphingosine kinase 1 in dextran sulfate sodium‐induced colitis (2009) (184)
- Biochemical Properties of Mammalian Neutral Sphingomyelinase2 and Its Role in Sphingolipid Metabolism* (2003) (181)
- Evaluating intrinsic and non-intrinsic cancer risk factors (2018) (179)
- Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids (2010) (177)
- Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria* (2001) (175)
- Regulation of protein kinase C and role in cancer biology (1994) (173)
- Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. (1986) (169)
- Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. (1993) (168)
- Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. (1994) (166)
- Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis (2007) (164)
- The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. (2003) (162)
- Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells* (1997) (162)
- FAS Activation Induces Dephosphorylation of SR Proteins (2001) (162)
- Ceramidases, roles in sphingolipid metabolism and in health and disease. (2017) (162)
- Identification of ISC1 (YER019w) as Inositol Phosphosphingolipid Phospholipase C inSaccharomyces cerevisiae * (2000) (162)
- The extended family of neutral sphingomyelinases. (2006) (161)
- Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae (2005) (161)
- Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis* (1997) (158)
- Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase* (1997) (157)
- Mitochondria and ceramide: intertwined roles in regulation of apoptosis. (2002) (156)
- Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases (2011) (156)
- Bioactive sphingolipids in the modulation of the inflammatory response. (2006) (155)
- Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas (2007) (155)
- Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. (2007) (152)
- Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells* (2004) (151)
- Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway (2008) (151)
- Protein Kinase C βII Specifically Binds to and Is Activated by F-actin* (1996) (151)
- Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells* (2007) (150)
- Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. (2003) (149)
- A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. (2005) (146)
- Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1* (2008) (145)
- Loss of sphingosine kinase‐1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis (2006) (145)
- The structural requirements for ceramide activation of serine-threonine protein phosphatases Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.M300347-JLR200 (2004) (144)
- The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate (2005) (143)
- Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. (2015) (140)
- Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids* (2006) (140)
- Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation* (2004) (140)
- Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. (1993) (138)
- Activation of Acid Sphingomyelinase by Protein Kinase Cδ-mediated Phosphorylation* (2007) (137)
- Down-regulation of Sphingosine Kinase-1 by DNA Damage (2004) (136)
- Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. (2017) (132)
- A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation (2011) (132)
- Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase* (2004) (128)
- Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses (2010) (126)
- Role for de Novo Sphingoid Base Biosynthesis in the Heat-induced Transient Cell Cycle Arrest of Saccharomyces cerevisiae * (2001) (126)
- Sphingolipid metabolism and neutral sphingomyelinases. (2013) (125)
- Translational aspects of sphingolipid metabolism. (2007) (125)
- Sphingolipids in inflammation: roles and implications. (2004) (125)
- Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. (1987) (123)
- Sphingolipids Signal Heat Stress-induced Ubiquitin-dependent Proteolysis* (2000) (122)
- Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells* (2001) (119)
- Bcl‐2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes (2002) (119)
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine (2010) (117)
- BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome* (2003) (116)
- The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. (2010) (115)
- Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. (2009) (115)
- Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. (1988) (114)
- Positively Charged Ceramide Is a Potent Inducer of Mitochondrial Permeabilization* (2005) (114)
- Visualization of Dynamic Trafficking of a Protein Kinase C βII/Green Fluorescent Protein Conjugate Reveals Differences in G Protein-coupled Receptor Activation and Desensitization* (1998) (114)
- Selective Involvement of Ceramide in Cytokine-induced Apoptosis (1997) (114)
- Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity* (2006) (113)
- Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain* (1998) (113)
- Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. (2004) (112)
- Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits (2010) (112)
- 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. (1995) (112)
- Identification and Characterization of Murine Mitochondria-associated Neutral Sphingomyelinase (MA-nSMase), the Mammalian Sphingomyelin Phosphodiesterase 5* (2010) (109)
- The functional effects of acid ceramidase over-expression in prostate cancer progression and resistance to chemotherapy (2007) (109)
- Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. (1993) (109)
- Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. (1992) (108)
- The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans (2012) (107)
- Sphingosine‐1‐phosphate receptor 2 (2013) (107)
- Platelet-activating Factor Receptor Activation (1998) (107)
- Evolving concepts in cancer therapy through targeting sphingolipid metabolism. (2014) (106)
- Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide* (2011) (106)
- Determination of ceramides and diglycerides by the diglyceride kinase assay. (2001) (105)
- Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism[S] (2011) (105)
- Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. (1993) (104)
- Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. (1992) (103)
- Phosphatidic Acid Is a Potent And Selective Inhibitor of Protein Phosphatase 1 and an Inhibitor of Ceramide-mediated Responses* (1999) (103)
- AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells (2009) (102)
- New insights on the use of desipramine as an inhibitor for acid ceramidase (2006) (102)
- Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line* (2001) (101)
- Function of the Cloned Putative Neutral Sphingomyelinase as Lyso-platelet Activating Factor-Phospholipase C* (1999) (101)
- Ceramide generation by two distinct pathways in tumor necrosis factor α‐induced cell death (2001) (100)
- Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid (2001) (99)
- Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells* (2008) (98)
- Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae * (2001) (98)
- Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. (1986) (98)
- Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor α-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells (2007) (96)
- Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death (2011) (96)
- Regulation of protein kinase C by sphingosine and lysosphingolipids. (1989) (95)
- Golgi fragmentation is associated with ceramide-induced cellular effects. (2005) (94)
- Novel Pathway of Ceramide Production in Mitochondria (2011) (93)
- Sphingolipid-binding proteins. (2006) (92)
- Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo (2006) (91)
- Role of sphingolipids in senescence: implication in aging and age‐related diseases (2018) (91)
- Tight Binding Inhibition of Protein Phosphatase-1 by Phosphatidic Acid (2002) (91)
- The Sphingolipid Pathway Regulates Pkc1 through the Formation of Diacylglycerol in Cryptococcus neoformans* (2004) (91)
- Modulation of cell growth and differentiation by ceramide (1992) (91)
- Protein kinase C and phospholipase D: intimate interactions in intracellular signaling (2005) (90)
- [25] Mixed micelle assay of protein kinase C (1986) (89)
- Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. (2007) (88)
- Tumor Necrosis Factor Induces the Loss of Sphingosine Kinase-1 by a Cathepsin B-dependent Mechanism* (2005) (88)
- Isc1 regulates sphingolipid metabolism in yeast mitochondria. (2007) (88)
- Acute Activation of de Novo Sphingolipid Biosynthesis upon Heat Shock Causes an Accumulation of Ceramide and Subsequent Dephosphorylation of SR Proteins* (2002) (88)
- Ceramide and sphingomyelinases in the regulation of stress responses. (1999) (88)
- Purification and Characterization of a Membrane-bound Nonlysosomal Ceramidase from Rat Brain* (1999) (86)
- Aminoacridines, potent inhibitors of protein kinase C. (1988) (85)
- Quantitative determination of ceramide using diglyceride kinase. (2000) (85)
- Regulation of volume‐activated chloride channels by P‐glycoprotein: phosphorylation has the final say! (2000) (84)
- Sphingolipids Function as Downstream Effectors of a Fungal PAQR (2009) (84)
- Regulation of Receptor-mediated Protein Kinase C Membrane Trafficking by Autophosphorylation* (2000) (84)
- Sphingolipids in colon cancer. (2014) (83)
- Ceramide induces interleukin 6 gene expression in human fibroblasts (1995) (82)
- Biochemical Characterization of the Reverse Activity of Rat Brain Ceramidase (2001) (78)
- Neutral sphingomyelinases and nSMase2: bridging the gaps. (2006) (78)
- An Essential Role for Autophosphorylation in the Dissociation of Activated Protein Kinase C from the Plasma Membrane* (1998) (78)
- Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells (2007) (78)
- Introduction: sphingolipids and their metabolites in cell regulation. (1993) (78)
- A novel role for protein kinase Cδ‐mediated phosphorylation of acid sphingomyelinase in UV light‐induced mitochondrial injury (2008) (78)
- Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells* (2008) (77)
- Differential Effects of Sphingomyelin Hydrolysis and Resynthesis on the Activation of NF-κB in Normal and SV40-transformed Human Fibroblasts* (2000) (74)
- Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models. (2004) (74)
- A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization (2011) (73)
- Proteolytic cleavage of phospholipase C–γ1 during apoptosis in Molt–4 cells (2000) (73)
- Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes (2007) (73)
- Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action. (1992) (73)
- Purification and characterization of ceramide-activated protein phosphatases. (1998) (72)
- Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. (2008) (71)
- Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis (1999) (71)
- A Role of Sphingosine Kinase 1 in Head and Neck Carcinogenesis (2011) (70)
- cPKC-dependent Sequestration of Membrane-recycling Components in a Subset of Recycling Endosomes* (2003) (69)
- Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy (2009) (69)
- Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. (1997) (69)
- Selective Substrate Supply in the Regulation of Yeast de Novo Sphingolipid Synthesis* (2007) (69)
- Defining a role for sphingosine kinase 1 in p53-dependent tumors (2011) (69)
- Regulated Secretion of Acid Sphingomyelinase (2010) (68)
- The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase (2009) (68)
- The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae (2014) (68)
- Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. (2013) (68)
- Activation and Localization of Inositol Phosphosphingolipid Phospholipase C, Isc1p, to the Mitochondria during Growth of Saccharomyces cerevisiae* (2004) (68)
- Activation of casein kinase II by sphingosine. (1991) (67)
- ISC1-dependent Metabolic Adaptation Reveals an Indispensable Role for Mitochondria in Induction of Nuclear Genes during the Diauxic Shift in Saccharomyces cerevisiae* (2009) (66)
- Molecular targeting of acid ceramidase: implications to cancer therapy. (2008) (66)
- Sphingosylphosphocholine Reduces the Calcium Ion Requirement for Activating Tissue Transglutaminase* (1997) (66)
- Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation (2010) (66)
- Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK* (2006) (65)
- Selective Inhibition of Juxtanuclear Translocation of Protein Kinase C βII by a Negative Feedback Mechanism Involving Ceramide Formed from the Salvage Pathway* (2005) (65)
- Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues (2007) (64)
- The neutral sphingomyelinase family: identifying biochemical connections. (2011) (64)
- Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies Published, JLR Papers in Press, September 16, 2002. DOI 10.1194/jlr.M200241-JLR200 (2002) (64)
- Acid Ceramidase but Not Acid Sphingomyelinase Is Required for Tumor Necrosis Factor-α-induced PGE2 Production* (2006) (63)
- Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation. (1990) (63)
- Use of sphingosine as inhibitor of protein kinase C. (1991) (62)
- Role for Furin in Tumor Necrosis Factor Alpha-Induced Activation of the Matrix Metalloproteinase/Sphingolipid Mitogenic Pathway (2007) (62)
- Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response (2011) (61)
- Intracellular sphingosine kinase 2‐derived sphingosine‐1‐phosphate mediates epidermal growth factor‐induced ezrin‐radixin‐moesin phosphorylation and cancer cell invasion (2015) (61)
- Functional Dichotomy of Protein Kinase C (PKC) in Tumor Necrosis Factor-α (TNF-α) Signal Transduction in L929 Cells (2000) (61)
- On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging (2014) (60)
- Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation (2017) (60)
- De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. (2008) (59)
- Acid ceramidase inhibition: a novel target for cancer therapy. (2008) (59)
- Murine Model for Colitis-Associated Cancer of the Colon. (2016) (59)
- The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation (2018) (59)
- Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein (2005) (58)
- Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse (2011) (58)
- Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. (2006) (58)
- Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. (2006) (58)
- Tailoring structure-function and targeting properties of ceramides by site-specific cationization. (2006) (58)
- Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. (2009) (58)
- Dihydrosphingosine 1‐phosphate stimulates MMP1 gene expression via activation of ERK1/2‐Ets1 pathway in human fibroblasts (2006) (58)
- A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation (2010) (57)
- Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report (2006) (57)
- Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through Gene Expression Profiling* (2003) (57)
- Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism (2012) (57)
- Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells (2006) (57)
- Ceramide, stress, and a "LAG" in aging. (2003) (57)
- Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-α Involves Protein Kinase C-δ in Lung Epithelial Cells (2008) (56)
- Sphingolipid-Mediated Signal Transduction (2013) (56)
- Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. (2013) (56)
- Ceramide Regulation of Apoptosis versus Differentiation: A Walk on a Fine Line. Lessons from Neurobiology (2002) (56)
- Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. (2014) (56)
- Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. (2010) (55)
- Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. (1990) (54)
- Dynamic Sequestration of the Recycling Compartment by Classical Protein Kinase C* (2006) (54)
- Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration (2015) (54)
- Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. (2004) (54)
- Modulation of Transforming Growth Factor-β (TGF-β) Signaling by Endogenous Sphingolipid Mediators* (2003) (54)
- Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. (2015) (54)
- Analysis of membrane topology of neutral sphingomyelinase 2 (2007) (54)
- The use of diglyceride kinase for quantifying ceramide. (1999) (54)
- Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism (2009) (53)
- P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment (2017) (52)
- Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. (1994) (52)
- 15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate. (1992) (51)
- The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C. (1989) (51)
- Acid ceramidase‐mediated production of sphingosine 1‐phosphate promotes prostate cancer invasion through upregulation of cathepsin B (2012) (51)
- Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. (2009) (51)
- Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. (1993) (51)
- Revealing a signaling role of phytosphingosine-1-phosphate in yeast (2010) (51)
- Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation (2012) (50)
- Identification of a novel amidase motif in neutral ceramidase. (2006) (50)
- The Phosphatidylglycerol/Cardiolipin Biosynthetic Pathway Is Required for the Activation of Inositol Phosphosphingolipid Phospholipase C, Isc1p, during Growth of Saccharomyces cerevisiae* (2005) (49)
- A novel role of sphingosine kinase‐1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma (2015) (49)
- Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. (1995) (49)
- MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. (2007) (49)
- Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. (2010) (48)
- Dihydroceramide desaturase activity is modulated by oxidative stress. (2010) (48)
- Sphingolipid metabolism and cell signaling (2000) (48)
- The yeast sphingolipid signaling landscape. (2014) (48)
- Role for Sit4p‐dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p‐deficient cells (2011) (48)
- Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. (2008) (48)
- Role of neutral ceramidase in colon cancer (2016) (47)
- Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. (2012) (47)
- Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis (2011) (47)
- Signal transduction and the regulation of apoptosis: roles of ceramide (1998) (46)
- Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. (2008) (46)
- The Roles of Neutral Sphingomyelinases in Neurological Pathologies (2012) (45)
- Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice (2020) (45)
- Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid (2015) (45)
- Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 (2017) (45)
- Protein kinase C: cellular target of the second messenger arachidonic acid? (1995) (45)
- Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells. (2011) (45)
- Involvement of Acid β-Glucosidase 1 in the Salvage Pathway of Ceramide Formation* (2009) (44)
- Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. (2015) (43)
- Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver (2005) (43)
- Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release (2012) (43)
- Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide–Dependent Neutral Sphingomyelinase 2/Ceramide Induction (2012) (43)
- Ceramide inhibition of NF‐κB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl‐terminal phosphorylation of PKC for the ceramide response (2001) (43)
- Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. (2006) (43)
- Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. (2003) (43)
- Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. (2005) (43)
- Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. (2004) (42)
- Visualizing bioactive ceramides. (2018) (42)
- Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition (2012) (42)
- Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. (2009) (41)
- Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction (2011) (40)
- Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. (1996) (40)
- Thematic Review Series: Sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases** This work was supported by National Institutes of Health Grants GM-63265 (Y.A.H.) and P20 RR-016461 (N.M.) (PACD program). Published, JLR Papers in Press, Fe (2008) (40)
- Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity* (2008) (40)
- Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. (2008) (40)
- Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death* (2015) (40)
- Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality. (2021) (40)
- Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. (2007) (39)
- Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension (2004) (39)
- Bcl-2 acts upstream of the PARP protease and prevents its activation (1997) (39)
- Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner* (2012) (38)
- Epidermal growth factor‐induced cellular invasion requires sphingosine‐1‐phosphate/sphingosine‐1‐phosphate 2 receptor‐mediated ezrin activation (2013) (37)
- Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells (2005) (37)
- Synthesis and bioevaluation of omega-N-amino analogs of B13. (2009) (37)
- Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a Classical Protein Kinase C- and Phospholipase D-dependent Manner* (2009) (37)
- Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain (2015) (36)
- Distinct Signaling Roles of Ceramide Species in Yeast Revealed Through Systematic Perturbation and Systems Biology Analyses (2013) (36)
- Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression (2003) (36)
- Purification, Characterization, and Identification of a Sphingomyelin Synthase from Pseudomonas aeruginosa (2003) (36)
- Essential Roles of Neutral Ceramidase and Sphingosine in Mitochondrial Dysfunction Due to Traumatic Brain Injury* (2014) (35)
- Novel chemotherapeutic drugs in sphingolipid cancer research. (2013) (35)
- Specific saposin C deficiency: CNS impairment and acid β-glucosidase effects in the mouse (2009) (35)
- Bcl‐2 antagonizes apoptotic cell death induced by two new ceramide analogues (1997) (34)
- Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. (2010) (34)
- Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. (1992) (33)
- Isoenzyme-specific Translocation of Protein Kinase C (PKC)βII and not PKCβI to a Juxtanuclear Subset of Recycling Endosomes (2004) (33)
- Substrate specificity of rat brain ceramidase. (2002) (33)
- Mechanism of Inhibition of Sequestration of Protein Kinase C α/βII by Ceramide (2007) (33)
- Identification of Novel Anionic Phospholipid Binding Domains in Neutral Sphingomyelinase 2 with Selective Binding Preference* (2011) (33)
- Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response (2016) (33)
- Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. (1989) (33)
- Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury (2017) (32)
- Metabolic Stress Opens K+ Channels in Hepatoma Cells through a Ca2+- and Protein Kinase Cα-dependent Mechanism* (1996) (32)
- Sphingosine kinase‐1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease (2006) (32)
- Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase* (2011) (32)
- Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. (1998) (32)
- Prodrug Modification Increases Potassium Tricyclo[5.2.1.02,6]-decan-8-yl Dithiocarbonate (D609) Chemical Stability and Cytotoxicity against U937 Leukemia Cells (2004) (31)
- Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3 (2021) (31)
- Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. (1990) (31)
- Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann‐Pick type C1 (2014) (31)
- Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α (2020) (31)
- Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice (2007) (31)
- Structural Requirements for Selective Binding of ISC1to Anionic Phospholipids* (2002) (31)
- Analysis and quantitation of ceramide. (2002) (31)
- Involvement of sphingolipids in apoptin-induced cell killing. (2006) (31)
- Sphingolipid second messengers: tumor suppressor lipids. (1997) (31)
- Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response. (2005) (30)
- Roles for C 16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-* □ (2005) (30)
- Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. (2000) (30)
- PKCα Mediates Maternal Touch Regulation of Growth-Related Gene Expression in Infant Rats (2003) (30)
- Asah2 Represses the p53–Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis (2021) (30)
- Coordination of Rapid Sphingolipid Responses to Heat Stress in Yeast (2013) (29)
- Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift (2007) (29)
- Functional analysis of ISC1 by site-directed mutagenesis. (2003) (29)
- Mixed micelle assay of protein kinase C. (1986) (29)
- Identification of C18:1-Phytoceramide as the Candidate Lipid Mediator for Hydroxyurea Resistance in Yeast* (2013) (29)
- A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. (2013) (28)
- Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation* (2013) (28)
- Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. (2012) (28)
- Platelets acquire a secretion defect after high‐dose chemotherapy (1990) (28)
- Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis (2021) (27)
- FAS Activation Induces Dephosphorylation of SR Proteins DEPENDENCE ON THE DE NOVO GENERATION OF CERAMIDE AND ACTIVATION OF PROTEIN PHOSPHATASE 1* (2001) (27)
- Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. (2014) (27)
- Stress-Induced Sphingolipid Signaling: Role of Type-2 Neutral Sphingomyelinase in Murine Cell Apoptosis and Proliferation (2010) (27)
- Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase* (2011) (27)
- Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. (2016) (26)
- Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. (1997) (26)
- Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism (2017) (26)
- Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. (2015) (26)
- Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis (2008) (26)
- Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. (2003) (26)
- An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S] (2018) (25)
- Mechanism of regulation of protein kinase C by lipid second messengers. (1986) (25)
- Hydroxyurea Sensitivity Reveals a Role for ISC1 in the Regulation of G2/M* (2009) (25)
- Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. (2014) (25)
- Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates (2018) (25)
- Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. (2017) (25)
- Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. (2012) (24)
- GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. (2015) (24)
- Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase (2017) (24)
- TNFα‐induced glutathione depletion lies downstream of cPLA2 in L929 cells (2001) (23)
- Multiphasic generation of diacylglycerol in thrombin-activated human platelets. (1992) (22)
- Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. (2007) (22)
- Defining a Role for Acid Sphingomyelinase in the p38/Interleukin-6 Pathway* (2014) (22)
- Cytokine response modifier A (CrmA): a strategically deployed viral weapon. (1998) (22)
- Bcl‐xL interrupts oxidative activation of neutral sphingomyelinase (2002) (22)
- Sphingolipid metabolism in the regulation of bioactive molecules (2007) (22)
- Mathematical Modeling and Validation of the Ergosterol Pathway in Saccharomyces cerevisiae (2011) (22)
- The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. (2014) (22)
- Sphingolipids and mitochondrial function in budding yeast. (2014) (21)
- Sphingoid Bases and the Serine Catabolic Enzyme CHA1 Define a Novel Feedforward/Feedback Mechanism in the Response to Serine Availability* (2012) (21)
- Dural MALT lymphoma with disseminated disease (2010) (21)
- A facile regioselective synthesis of sphingosine 1-phosphate and ceramide 1-phosphate (2000) (21)
- A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines (1995) (21)
- Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis (2013) (21)
- Distinct Roles for Hematopoietic and Extra-Hematopoietic Sphingosine Kinase-1 in Inflammatory Bowel Disease (2014) (21)
- Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. (1993) (20)
- AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells (2018) (20)
- Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5[S] (2018) (20)
- IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice (2015) (20)
- Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration (2015) (20)
- Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function (2016) (19)
- Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease (2015) (19)
- Wu et al. reply (2017) (19)
- Decreased ceramide underlies mitochondrial dysfunction in Charcot‐Marie‐Tooth 2F (2017) (19)
- Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells (2017) (19)
- Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis (2017) (19)
- Sphingolipids in vascular biology. (2002) (19)
- PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. (2003) (18)
- Cellular Morphogenesis Under Stress Is Influenced by the Sphingolipid Pathway Gene ISC1 and DNA Integrity Checkpoint Genes in Saccharomyces cerevisiae (2011) (18)
- Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation. (2020) (18)
- Immunolocalization of PKCξ in rat photoreceptor inner segments (1994) (18)
- Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. (2019) (18)
- Effect of sphingosine kinase 1 inhibition on blood pressure (2013) (18)
- Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S] (2018) (18)
- Confluence induced threonine41/serine45 phospho-β-catenin dephosphorylation via ceramide-mediated activation of PP1cγ (2007) (17)
- Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy (2021) (17)
- Bioactive Sphingolipids in Cancer Biology and Therapy (2015) (17)
- Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment (2017) (17)
- A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway (2017) (16)
- Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. (2010) (16)
- Ceramide: A Novel Second Messenger and Lipid Mediator (1996) (16)
- Computational analysis of sphingolipid pathway systems. (2010) (16)
- Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor (2013) (16)
- Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calciums⃞ Published, JLR Papers in Press, December 12, 2006. (2007) (16)
- Ceramide and sphingosine-1-phosphate in cancer, two faces of the sphinx (2015) (16)
- GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis (2021) (15)
- Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. (2010) (15)
- Functions of neutral ceramidase in the Golgi apparatus (2018) (15)
- The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. (1993) (15)
- Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network (2014) (15)
- Erratum: 12(S)-Hydroxyeicosatetraenoic acid and 13(S)- hydroxyoctadecadienoic acid regulation of protein kinase C-α in melanoma cells: Role of receptor-mediated hydrolysis of inositol phospholipids (Cell (September 26, 1995) 92:20 (9323-9327)) (1995) (15)
- Apoptosis in Neurobiology (1998) (15)
- Identification and characterization of protein phosphatase 2C activation by ceramide[S] (2012) (15)
- Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy (2020) (14)
- Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. (1994) (14)
- Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells (2011) (14)
- Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation (2017) (14)
- Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells (2021) (14)
- Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells (2017) (14)
- Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. (1992) (14)
- Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase. (2011) (13)
- Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae[S] (2017) (13)
- Protein kinase C regulation by sphingosine/lysosphingolipids. (1988) (12)
- Exploring the Therapeutic Landscape of Sphingomyelinases. (2018) (12)
- Preparation of radiolabeled ceramides and phosphosphingolipids. (2000) (12)
- Analysis of ceramide-activated protein phosphatases. (2000) (12)
- Author Correction: Sphingolipids and their metabolism in physiology and disease (2018) (12)
- The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. (2018) (11)
- Emergence of membrane sphingolipids as a potential therapeutic target. (2019) (11)
- Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S] (2018) (11)
- Synthesis of key precursors of radiolabeled sphingolipids. (2000) (11)
- CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles (2016) (10)
- Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats (2009) (10)
- Approaches for probing and evaluating mammalian sphingolipid metabolism. (2019) (10)
- A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis (2015) (10)
- Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. (2007) (10)
- A guide to biochemical systems modeling of sphingolipids for the biochemist. (2007) (10)
- The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme (2019) (10)
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- Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker’s Yeast (2015) (10)
- PKCα is required for Akt-mTORC1 activation in Non-Small Cell Lung Carcinoma (NSCLC) with EGFR mutation (2019) (9)
- Sphingosine 1-phosphate activation of ERM contributes to vascular calcification[S] (2017) (9)
- Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols (2015) (9)
- Ceramide-Enriched Membrane Domains in Red Blood Cells and the Mechanism of Sphingomyelinase-Induced Hot-Cold Hemolysis (2009) (9)
- Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. (2019) (9)
- Delayed Phosphorylation of Classical Protein Kinase C (PKC) Substrates Requires PKC Internalization and Formation of the Pericentrion in a Phospholipase D (PLD)-dependent Manner* (2011) (9)
- Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion (1991) (9)
- Molecular Characterization of Rice OsLCB2a1 Gene and Functional Analysis of its Role in Insect Resistance (2016) (9)
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- Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway[S] (2018) (9)
- Regulation of Protein Kinase C by Lipid Cofactors (1987) (8)
- Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens (2017) (8)
- Acid β-Glucosidase 1 Counteracts p38δ-dependent Induction of Interleukin-6 (2009) (8)
- Mixed micellar assay for phorbol ester binding. (1987) (8)
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- Transcriptional Regulation of Sphingosine Kinase 1 (2020) (8)
- Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer (2021) (8)
- Erratum to “Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids” [Bioorg. Med. Chem. 16 (2008) 1032–1045] (2008) (8)
- A Role of Sphingosine Kinase 1 in head & neck carcinogenesis (2010) (7)
- Identification and Biochemical Characterization of an Acid Sphingomyelinase-Like Protein from the Bacterial Plant Pathogen Ralstonia solanacearum that Hydrolyzes ATP to AMP but Not Sphingomyelin to Ceramide (2014) (7)
- Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury (2022) (7)
- Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria. (2018) (7)
- Local correlation of expression profiles with gene annotations-proof of concept for a general conciliatory method (2005) (7)
- Defects in Cell Growth Regulation by C 18 : 0-Ceramide and Longevity Assurance Gene 1 ( LAG 1 ) in Human Head and Neck Squamous Cell Carcinomas ( HNSCC ) # (2004) (7)
- Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells. (1993) (7)
- Immunolocalization of PKC zeta in rat photoreceptor inner segments. (1994) (6)
- TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. (2001) (6)
- Metabolism and Roles of Sphingolipids in Yeast Saccharomyces cerevisiae (2019) (6)
- The importance of extrinsic factors in the development of cancers (2016) (6)
- Build a registry of results that students can replicate (2021) (6)
- 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase (2021) (6)
- Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation (2021) (6)
- Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases (2021) (6)
- Synthesis and bioevaluation of ω -N-amino analogs of B13 (2009) (6)
- RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis (2019) (6)
- Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. (2018) (5)
- The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation (2019) (5)
- Qualitative and Quantitative Measurements of Sphingolipids by Mass Spectrometry (2015) (5)
- Dynamics of Positional Enrichment: Theoretical Development and Application to Carbon Labeling in Zymomonas mobilis. (2008) (5)
- Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid (2020) (5)
- 15 Bioactive Sphingolipids: An Overview on Ceramide, Ceramide 1-Phosphate Dihydroceramide, Sphingosine, Sphingosine 1-Phosphate (2009) (5)
- Ceramide synthase 2‐C24:1‐ceramide axis limits the metastatic potential of ovarian cancer cells (2021) (5)
- Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment (2013) (5)
- Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases[S] (2019) (5)
- Lipids and apoptosis: foreword (2002) (4)
- Ceramide, a Sphingolipid Second Messenger (1994) (4)
- Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer (2005) (4)
- Series : Sphingolipids ISC 1 ( inositol phosphosphingolipid-phospholipase C ) , the yeast homologue of neutral sphingomyelinases (2008) (4)
- Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function (2020) (4)
- Potent Anti-Tumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or In Combination with Gemcitabine Against Human Head and Neck Squamous Cell Carcinomas In vitro and In vivo (2006) (4)
- Go-6976 Reverses Hyperglycemia-Induced Insulin Resistance Independently of cPKC Inhibition in Adipocytes (2014) (4)
- Functions and breakdown products (1993) (4)
- Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides (2021) (4)
- Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast (2016) (4)
- Peripheral ß-glucocerebrosidase enzyme activity and lipidomics in ß-glucocerebrosidase (GBA1) mutation Parkinson disease (P2.149) (2015) (4)
- TNF INDUCES THE LOSS OF SPHINGOSINE KINASE-1 BY A CATHEPSIN B DEPENDENT MECHANISM (2005) (4)
- Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. (2016) (3)
- The sphingomyelin cycle: The flip side of the lipid signaling paradigm (1997) (3)
- Highly Efficient and Regioselective Phosphorylation of Sphingolipids by Phase-Trans fer Catalysis (2007) (3)
- Identification and Characterization of Murine Mitochondria- associated Neutral Sphingomyelinase (MA-nSMase), the (2010) (3)
- Retrograde Transport of Golgi Enzymes by GOLPH3 Across Maturing Cisternae Regulates Glycan Assembly on Sphingolipids and Cell Growth (2019) (3)
- Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation. (2021) (3)
- Chapter 21 Lipids as second messengers (1997) (3)
- NIH: grants revamp needs grounding in evidence (2008) (2)
- A personal journey with bioactive lipids (2015) (2)
- Regulation of Protein Kinase C (1991) (2)
- Overview of Acid and Neutral Sphingomyelinases in Cell Signaling (2006) (2)
- Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. (2020) (2)
- Sphingolipids as Mediators of Breast Cancer Progression, Metastasis, Response and Resistance to Chemotherapy (2015) (2)
- Chapter 6 – Ceramides (2012) (2)
- Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers. (1987) (2)
- The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling (2013) (2)
- Cytosolic Ca 2 1 and Protein Kinase C a Couple Cellular Metabolism to Membrane K 1 Permeability in a Human Biliary Cell Line (2013) (2)
- Preparation of Radiolabeled Ceramides and Phosphosphingolipids (2000) (2)
- Functional Lipidomics: Lessons and Examples from the Sphingolipids (2005) (2)
- Identifi cation and characterization of protein phosphatase 2 C activation by ceramide (2012) (2)
- Ceramide: A Stress Response Mediator Involved in Growth Suppression (1997) (2)
- phosphate and ceramide-1-phosphate (2005) (2)
- The doxorubicin‐induced cell motility network is under the control of the ceramide‐activated protein phosphatase 1 alpha (2021) (2)
- Skn 1 and Ipt 1 negatively regulateautophagy in Saccharomyces cerevisiae (2010) (2)
- Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain (2018) (2)
- Chapter 2 – Diacylglycerols (2012) (2)
- Dynamic Sequestration of the Recycling Compartment by cPKC (2006) (2)
- Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism (2020) (2)
- Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening (2020) (2)
- Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC). (2011) (2)
- Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice (2020) (1)
- Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma (2019) (1)
- Ceramide: A Central Regulator of the Cellular Response to Injury and Stress (1997) (1)
- Function of Sphingolipid Metabolites in Cell Regulation (1993) (1)
- Roles for C 16 -ceramide and sphingosine-1-phosphate in regulating hepatocyte apoptosis in response to TNF- a * (2005) (1)
- Interaction of Ceramide Synthase with Long Chain Fatty Acyl‐CoA Synthase 5 Channels de novo Ceramide to Acylceramide Generation by Diacylglycerol Acyltransferase 2 on Lipid Droplets (2015) (1)
- Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation (2019) (1)
- We need to tackle the mismatch between supply and demand (2009) (1)
- CHAPTER 165 – The Role of Ceramide in Cell Regulation (2003) (1)
- Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research (2007) (1)
- Detection and Distribution of Sphingolipids in Tissue by FTICR MALDI-Imaging Mass Spectrometry (2015) (1)
- Highly Efficient and Regioselective Phosphorylation of Sphingolipids by Phase‐Transfer Catalysis. (2008) (1)
- Protein Kinase C Regulation by Diacylglycerols: Structure-Function Relationships and Mechanism (1986) (1)
- A novel role of Inositol Phosphosphingolipid Phospholipase C gene (ISC1) in morphogenesis during replication stress (2011) (1)
- Swe1‐dependent and Swe1‐independent pathways controlling Hydroxyurea resistance in Saccharomyces cerevisiae (2012) (1)
- Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer (2021) (1)
- Agonist-Induced G Protein-Coupled Receptors (GPCRs) Trafficking and Signaling is Regulated by PKC-dependent Sequestration of Recycling Components (2007) (1)
- Regulation and function of metabolism (1993) (1)
- Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis (2022) (1)
- Apoptosis: Ceramide and Lipid Mediators in Apoptosis (2011) (1)
- Requirements for Long-chain ( Sphingoid ) Base Inhibition of Protein Kinase C in Vitro and for the Cellular Effects of These Compoundsf (2001) (1)
- New role for ceramide in the pheromone response (2016) (0)
- Specificity andmechanism ofprotein kinase Cactivation by (1986) (0)
- Control of the sphingolipid rheostat by the protein kinase Sch9 in Saccharomyces cerevisiae (2013) (0)
- Dual Site Mechanism Governs Sphingosine Kinase 1 Membrane Binding and Biological Function (2017) (0)
- Ceramide Disrupts HLA Class II‐restricted Antigen Processing and Presentation (2008) (0)
- Sphingolipid-Mediated Apoptosis and Tumor Suppression in Breast Carcinoma (1998) (0)
- 1011. A Combination of Ceramide Analogue and FasL Gene Therapy Can Be a Potential Novel Therapy for Prostate Cancer (2005) (0)
- Generation of Signaling Molecules by De Novo Sphingolipid Synthesis (2006) (0)
- Acid Sphigomylelinase Plays a Role in IR-induced Retinal Degeneration (2012) (0)
- 405: Lysosomotropic Ceramide Analogue LCL-204, Acid Ceramidase (AC) Inhibitor, a Potential Novel Chemotherapy for Prostate Cancer (PCA) (2005) (0)
- The Role of Ceramide in the Cellular Stress Response (1996) (0)
- Mitochondrially targeted ceramide preferentially promotes autophagy , retards cell growth , and induces apoptosis (2010) (0)
- Due to Traumatic Brain Injury Sphingosine in Mitochondrial Dysfunction Essential Roles of Neutral Ceramidase and Lipids (2014) (0)
- Acid Sphingomyelinase Deficiency Induces Age-related Degeneration In The Mouse Retina (2012) (0)
- Crystal structure of human neutral ceramidase with Zn-bound phosphate (2015) (0)
- Factor- involves Protein Kinase C- in Lung Epithelial Cells (2008) (0)
- 450. Combination of Fas Gene Therapy and Ceramide Analogues: A Double Edge Sword for the Treatment of Head and Neck Cancer (2005) (0)
- Thrombin-Induced Platelet Functions Occurs Via Enhanced Production of Phosphoinositide-Derived Second Messengers-sn1 , 2-Diacylglycerol and Inositol-1 , 4 , 5-Trisphosphate (2003) (0)
- Abstract A59: A tumor supressor role for nSMase2 in triple negative breast cancer (2022) (0)
- A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane (2022) (0)
- Lymphocytes Affected in Cystic Fibrosis? (2005) (0)
- Spingomyelin synthase and PKC activation. Response (1989) (0)
- Introduction: Occurrence, Mechanisms, and Role of Apoptosis in Neurobiology and in Neurologic Disorders (1998) (0)
- Response : Sphingomyelin Synthase and PKC Activation (1989) (0)
- Phorbol esters and diacylglycerols: preparation, quantitation, and binding (1987) (0)
- 441 RPGRIP1L facilitates desmosomal adhesion through suppressing PKCβII-mediated desmoglein endocytosis: Implication in pemphigus (2016) (0)
- Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases (2018) (0)
- Analyzing the Sphingomyelin Cycle:Protocols for Measuring Sphingomyelinase, Sphingomyelin, and Ceramide (2020) (0)
- Systems Biology Approaches for Studying Sphingolipid Signaling (2015) (0)
- Ceramide Inactivates Cellular Protein Kinase C (cid:97) * (1996) (0)
- Skn1and Ipt1negatively regulate autophagy in Saccharomycescerevisiae (2010) (0)
- 928. Reversal of PPC1 Prostate Cancer Cells Radioresistance by Degradation of Acid Ceramidase Using the Lysosomotropic Drug LCL385 (2006) (0)
- Abstract B80: Role for sphingosine kinase 1 in colon carcinogenesis (2010) (0)
- Author Correction: Sphingolipids and their metabolism in physiology and disease (2018) (0)
- Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells (2018) (0)
- Abstract 5656: Role for Sphingosine kinase 1 in head & neck cancer (2010) (0)
- 802: Modulation of Ceramide Metabolism Enhances Tumor-Selective Viral Protein Apoptin’s Cytotoxicity in Prostate Cancer (2006) (0)
- Lysosomal Diseases and the Brain Conference Organized by the Children ’ s Gaucher Research Fund---Speaker (2010) (0)
- A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer (2021) (0)
- Erratum: Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. (2021) (0)
- Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail (2023) (0)
- ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding (2022) (0)
- 335 ACID SPHINGOMYELINASE MEDIATES CISPLATIN-INDUCED CYTOSKELETAL REMODELING. (2007) (0)
- 49. Inhibition of Acid Ceramidase Expression by Small Interfering RNA Sensitize Human Prostae Cancer Cells to Apoptin Induced Cell Death (2006) (0)
- C6‐pyridinium ceramide induces Bax translocation from cytosol to mitochondria in MCF‐7 cells via a new signaling pathway (2006) (0)
- Regulation of ERM cytoskeletal proteins by sphingolipids (2011) (0)
- Apoptosis Triggered by the Absence of an Integrin Signal: Role of the Sphingolipid Ceramide (1999) (0)
- Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis (2021) (0)
- Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides (2021) (0)
- Differentiate and switch, a tale of two heads of a lipid (2018) (0)
- THE ROLE OF SPHINGOLIPIDS IN STRESS RESPONSES AND APOPTOSIS IN EUKARYOTES (1999) (0)
- Neutral ceramidase acts in concert with thioesterase to produce ceramide in mitochondria (2011) (0)
- Response:Sphingomyelin synthase and PKC activation (1989) (0)
- Roles of ceramide in TNF action (1999) (0)
- Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound (2017) (0)
- ACID SPHINGOMYELINASE MEDIATES CISPLATIN-INDUCED CYTOSKELETAL REMODELING.: 335 (2007) (0)
- Peripheral Sphingolipids as Potential Biomarkers of Parkinson disease Including Sex-Related Differences (P3-11.007) (2023) (0)
- Angiotensin increases diacylglycerol levels in bovine adrenal medullary cells (1990) (0)
- CrmA inhibits TNFa-induced apoptosis by a mechanism upstream and distinct from Bcl-2 (1996) (0)
- Long‐Chain Glycosphingolipids Mediate Renal Aging (2011) (0)
- The Roles of Neutral Sphingomyelinases in Neurological Pathologies (2012) (0)
- Sphingomyelinases in the regulation of ceramide formation and function (2011) (0)
- COMBINATION OF FASL GENE THERAPY AND LCL204: A NEW EXCITING THERAPEUTIC MODALITY FOR HEAD AND NECK CANCER.: 167 (2007) (0)
- Subject Index to Volume 15 (2001) (0)
- The Integrin-Mediated Suppression of Apoptosis Correlates with Suppression of Ceramide Generation † 780 (1998) (0)
- Erratum: Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 (Cell Metabolism (2013) 17 (901-915)) (2014) (0)
- Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. (2021) (0)
- 12 Baker’s Yeast: a rising foundation for eukaryotic sphingolipid-mediated cell signaling (2003) (0)
- PKCα Mediates mTORC1 Activation in Non‐Small Cell Lung Carcinoma Cells with EGFR Deletion Mutation (2019) (0)
- 539: Radiation Therapy Upregulates Coxsackie-Adenovirus Receptor in Prostate Cancer Cells and Sensitizes Prostate Cancer to Fas Ligand Gene Therapy (2007) (0)
- Abstract 2497: Induction of AP-1 activity by ceramide results in ASAH1 upregulation: A mechanism of prostate cancer cell radioresistance (2011) (0)
- 924. D-MAPP Analogue, LCL-204 Sensitizes DU145 Prostate Cancer Cells (PCa) to FasL Gene Therapy through Down-Regulation of Survivin (2006) (0)
- Neutral ceramidase regulates ferroptosis in myeloid-derived suppressor cells (2020) (0)
- Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases (2021) (0)
- DELAYED PHOSPHORYLATION OF CPKC SUBSTRATES REQUIRES PKC INTERNALIZATION AND FORMATION OF THE PERICENTRION IN A PLD DEPENDENT MANNER (2011) (0)
- Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population (2023) (0)
- 220 Regulation of Vascular Calcification by Bioactive Sphingolipids (2015) (0)
- The ceramide activated protein phosphatase Sit 4 imp airs sphingolipid dynamics , 1 mitochondrial function and lifespan in a yeast mode l of Niemann-Pick type C 1 2 3 (2017) (0)
- Crystal structure and activation mechanism of human neutral sphingomyelinase 2 (2017) (0)
- Neutral Sphingomyelinase: structure and function (2017) (0)
- 137. In vivo evaluation of small molecule therapy on Gaucher disease mouse models (2009) (0)
- Evaluating intrinsic and non-intrinsic cancer risk factors (2018) (0)
- 668: Acid Ceramidase Upregulation in Response to Prostate Cancer Radiotherapy: A Target for Radio-Sensitization (2007) (0)
- Sch9 affects sphingolipid metabolism and sphingolipid-mediated signalling in Saccharomyces cerevisiae (2009) (0)
- Abstract 2589: Dissecting extrinsic and intrinsic cancer risk (2016) (0)
- Feodor Lynen Lecture - The Extended Family of Neutral Sphingomyelinases (2007) (0)
- Sustained treatment of PMA affects trafficking and signaling of EGFR (2011) (0)
- Sphingolipids on acquired resistance to 4-HPR (2010) (0)
- STUDY REVEALS ENVIRONMENT, BEHAVIOR CONTRIBUTE TO SOME 80 PERCENT OF CANCERS (2015) (0)
- A Facile Regioselective Synthesis of Sphingosine 1‐Phosphate (IV) and Ceramide 1‐Phosphate (VIII) (2000) (0)
- 676. A Role for Ceramide in AdGFPFasLTET Gene Therapy|[ast]| (2004) (0)
- Short-Term Palmitate Exposure or Acute High Fat Feeding Promotes a Foamy and Inflammatory Macrophage Phenotype Which Involves ACSL1-Associated Signaling via the CD36/FABP4/P38/PPARδ Axis (2022) (0)
- 938. Ceramide May Have a Role in Sensitizing ACHN Renal Cancer Cells (RCC) to Fas Induced Apoptosis (2006) (0)
- GATA1-Dependent Ceramide Homeostasis Controls Cytokine Signaling and Erythroid Cell Function (2022) (0)
- Sch9, the orthologue of mammalian PKB, acts as a regulator of the sphingolipid rheostat in Saccharomyces cerevisiae (2013) (0)
- Cytosolic Ca 2 (cid:49) and Protein Kinase C (cid:97) Couple Cellular Metabolism to Membrane K (cid:49) Permeability in a Human Biliary Cell Line (1997) (0)
- Sphingoid bases mediate localization of Dcp2 to mRNA processing bodies during heat stress (2007) (0)
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