Yutaka Seino

Q: What Schools Are Affiliated With Yutaka Seino

Yutaka Seino is affiliated with the following schools: University of Oxford, Kobe University, University of Tokyo, Kansai Medical University, Institute of Science Tokyo, University of Toronto, Kyoto University

Yutaka Seino's AcademicInfluence.com Rankings

Yutaka Seino

Computer Science

#5532

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#5842

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Computational Linguistics

#795

World Rank

#808

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Machine Learning

#1508

World Rank

#1530

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Artificial Intelligence

#1743

World Rank

#1775

Historical Rank

computer-science Degrees

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Computer Science

Yutaka Seino's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science Kyoto University
Bachelors Computer Science Kyoto University

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Yutaka Seino's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus (2010) (1938)
Inhibition of gastric inhibitory polypeptide signaling prevents obesity (2002) (829)
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus (2008) (739)
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. (2002) (566)
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. (1999) (512)
Over-expression of facilitative glucose transporter genes in human cancer. (1990) (461)
GIP and GLP‐1, the two incretin hormones: Similarities and differences (2010) (461)
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. (1999) (459)
Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. (1988) (393)
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. (2004) (321)
Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (1992) (304)
Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. (2004) (284)
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. (2007) (268)
Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. (1994) (267)
The murine glucagon-like peptide-1 receptor is essential for control of bone resorption. (2008) (258)
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. (2001) (253)
Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)* (2012) (247)
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential. (2014) (240)
β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians (2015) (227)
Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1: Incretin actions beyond the pancreas (2013) (212)
Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes. (2004) (201)
Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion. (2006) (186)
Cdk5-dependent regulation of glucose-stimulated insulin secretion (2005) (181)
Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation. (2011) (178)
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus (2002) (173)
Distribution of the glucose transporters in human brain tumors. (1992) (173)
Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese (1997) (173)
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. (2008) (143)
Incretin‐based drugs for type 2 diabetes: Focus on East Asian perspectives (2016) (142)
Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. (2001) (138)
Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes. (2008) (127)
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. (2003) (120)
Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes (2010) (119)
Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6. (1994) (118)
Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes (2000) (114)
Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes. (1985) (107)
Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. (1987) (105)
Efficacy and safety of luseogliflozin as monotherapy in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, phase 3 study (2014) (105)
An Insulinotropic Effect of Vitamin D Analog with Increasing Intracellular Ca2+ Concentration in Pancreatic β-Cells through Nongenomic Signal Transduction1. (1999) (105)
Effect of corosolic acid on postchallenge plasma glucose levels. (2006) (105)
Glucose Sensitivity of ATP-Sensitive K+ Channels Is Impaired in β-Cells of the GK Rat: A New Genetic Model of NIDDM (1993) (103)
Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs (1978) (100)
Effects of various gastrointestinal peptides on gastric somatostatin release. (1980) (97)
c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. (1992) (97)
Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin. (1984) (96)
Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects (2006) (93)
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects (2008) (92)
A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control (2010) (90)
Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation. (2006) (90)
Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 diabetes mellitus. (2000) (89)
Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance (2003) (88)
Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure. (2008) (88)
Improved glycaemic control with minimal hypoglycaemia and no weight change with the once‐daily human glucagon‐like peptide‐1 analogue liraglutide as add‐on to sulphonylurea in Japanese patients with type 2 diabetes (2010) (88)
Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A-G) mutation in Japanese: maternal inheritance and mitochondria-related complications. (2003) (87)
Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (1995) (86)
Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. (2002) (83)
Little enhancement of meal‐induced glucagon‐like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls (2010) (83)
Tissue distribution and species difference of the brain type glucose transporter (GLUT3). (1991) (82)
Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells (1994) (82)
Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice. (2009) (82)
T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats. (2000) (81)
Mechanism of sympathetic neural regulation of insulin, somatostatin, and glucagon secretion. (1990) (80)
Overexpression of Inducible Cyclic AMP Early Repressor Inhibits Transactivation of Genes and Cell Proliferation in Pancreatic β Cells (2004) (80)
Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity. (2005) (79)
Effects of glucagon, secretin, and vasoactive intestinal polypeptide on gastric somatostatin and gastrin release from isolated perfused rat stomach (1980) (78)
Effects of thorough mastication on postprandial plasma glucose concentrations in nonobese Japanese subjects. (2005) (78)
Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy. (2016) (77)
Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene. (1989) (77)
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. (2005) (76)
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association (2009) (76)
14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity (2005) (75)
Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. (2006) (75)
High Prevalence of Autoantibodies Against Carbonic Anhydrase II and Lactoferrin in Type 1 Diabetes: Concept of Autoimmune Exocrinopathy and Endocrinopathy of the Pancreas (2003) (74)
A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice. (2008) (74)
Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial. (2020) (74)
Curcumin inhibits glucose production in isolated mice hepatocytes. (2008) (74)
Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes. (1996) (74)
Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study (2011) (73)
Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase. (2007) (73)
Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats. (1996) (72)
Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetes. (2001) (72)
Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial (2015) (71)
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes. (2006) (71)
Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes. (2010) (71)
[Radioimmunoassay of gastric inhibitory polypeptide]. (1983) (71)
Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure. (1993) (71)
Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. (2004) (71)
Bone marrow transplantation as a strategy for treatment of non-insulin- dependent diabetes mellitus in KK-Ay mice (1992) (71)
Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells. (1995) (71)
Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia. (2003) (69)
Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis (2018) (69)
Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2. (2005) (69)
Abnormality in fibre type distribution of soleus and plantaris muscles in non‐obese diabetic Goto‐Kakizaki rats (2002) (69)
Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. (2000) (67)
Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events (2015) (67)
Diabetic osteopenia: pathophysiology and clinical aspects. (1995) (67)
Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells. (2000) (66)
Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double‐blind, placebo‐controlled trial with an open‐label, long‐term extension study (2012) (66)
Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice. (2008) (64)
Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes (2014) (64)
Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese. (2003) (64)
Impaired beta-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance. (2003) (63)
GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. (2011) (63)
Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. (1998) (62)
Comparison of incretin immunoassays with or without plasma extraction: Incretin secretion in Japanese patients with type 2 diabetes (2011) (62)
Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets. (2002) (62)
Expression of the CRE-BP1 transcriptional regulator binding to the cyclic AMP response element in central nervous system, regenerating liver, and human tumors. (1991) (61)
Effect of ginseng radix on GLUT2 protein content in mouse liver in normal and epinephrine-induced hyperglycemic mice. (1996) (61)
Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice. (1995) (61)
Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide (2006) (60)
Safety and efficacy of semaglutide once weekly vs sitagliptin once daily, both as monotherapy in Japanese people with type 2 diabetes (2017) (60)
Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension (2011) (59)
Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat. (1987) (59)
Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets. (1998) (58)
Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double‐blind, placebo‐controlled trial with an open‐label long‐term extension study (2011) (58)
Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients. (2003) (58)
Suppressive effect of GABA on insulin secretion from the pancreatic beta-cells in the rat. (1993) (56)
Effect of Antisomatostatin γ-Globulin on Gastrin Release in Rats (1981) (56)
Synthetic Gastric Inhibitory Polypeptide Stimulatory Effect on Insulin and Glucagon Secretion in the Rat (1977) (55)
Sodium‐glucose co‐transporter‐2 inhibitor use and dietary carbohydrate intake in Japanese individuals with type 2 diabetes: A randomized, open‐label, 3‐arm parallel comparative, exploratory study (2016) (55)
Influence of Renal Function on the 52-Week Efficacy and Safety of the Sodium Glucose Cotransporter 2 Inhibitor Luseogliflozin in Japanese Patients with Type 2 Diabetes Mellitus. (2016) (55)
Somatostatin release from isolated perfused rat stomach. (1978) (54)
An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction. (1999) (54)
Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density. (2005) (53)
Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes. (2000) (53)
Expression of GLUT1 and GLUT2 Glucose Transporter Isoforms in Rat Islets of Langerhans and Their Regulation by Glucose (1992) (53)
Alpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese. (2003) (51)
Vagal regulation of GRP, gastric somatostatin, and gastrin secretion in vitro. (1985) (51)
Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways. (1997) (51)
Liver and muscle-fat type glucose transporter gene expression in obese and diabetic rats. (1991) (50)
Release of cholecystokinin and gallbladder contraction before and after gastrectomy. (1987) (50)
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. (2015) (50)
Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients. (2003) (49)
Incretin actions beyond the pancreas: lessons from knockout mice. (2013) (48)
Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. (2017) (48)
Dipeptidyl peptidase‐4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe? (2014) (47)
Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitus (2009) (47)
Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats1 (2002) (47)
Establishment of a diabetic mouse model with progressive diabetic nephropathy. (2005) (47)
The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity. (1999) (47)
Physiology of GIP--a lesson from GIP receptor knockout mice. (2004) (47)
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto). (1992) (47)
Efficacy and safety of luseogliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: a 12-week, randomized, placebo-controlled, phase II study (2014) (47)
Combination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: A 36‐week, randomized, double‐blind, parallel‐group trial (2016) (47)
Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secreting cells: its structure and functional properties. (1994) (47)
Starvation-induced Changes of Somatostatin, Glucagon, and Insulin Secretion from the Isolated Perfused Rat Pancreas (1980) (46)
Correlations between bone mineral density and circulating bone metabolic markers in diabetic patients. (2000) (46)
Dose-finding study of luseogliflozin in Japanese patients with type 2 diabetes mellitus: a 12-week, randomized, double-blind, placebo-controlled, phase II study (2014) (45)
Hepatic safety profile and glycemic control of pioglitazone in more than 20,000 patients with type 2 diabetes mellitus: postmarketing surveillance study in Japan. (2007) (45)
Fifty‐two‐week, randomized, multicenter trial to compare the safety and efficacy of the novel glucagon‐like peptide‐1 analog liraglutide vs glibenclamide in patients with type 2 diabetes (2011) (45)
The Novel Insulinotropic Mechanism of Pimobendan: Direct Enhancement of the Exocytotic Process of Insulin Secretory Granules by Increased Ca2+ Sensitivity inβ -Cells. (1998) (44)
Effect of corosolic acid on gluconeogenesis in rat liver. (2008) (44)
Utility of indices using C‐peptide levels for indication of insulin therapy to achieve good glycemic control in Japanese patients with type 2 diabetes (2011) (43)
Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) investigatars. (2008) (43)
Efficacy and safety of luseogliflozin added to various oral antidiabetic drugs in Japanese patients with type 2 diabetes mellitus (2015) (43)
C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients. (2002) (43)
Interaction of somatostatin and calcium in regulating insulin release from isolated pancreatic islets of rats. (1975) (43)
The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. (1998) (42)
[Immunoassays for the incretin hormones GIP and GLP-1]. (2011) (41)
Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity (2001) (41)
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice (2010) (41)
The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. (1995) (41)
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. (2008) (40)
Effects of glucagon, secretin, and vasoactive intestinal polypeptide on gastric somatostatin and gastrin release from isolated perfused rat stomach. (1980) (40)
Insulin Action in the Double Incretin Receptor Knockout Mouse (2008) (40)
Follow-up Study of the First Successful Living Donor Islet Transplantation (2006) (40)
Sequence of an intestinal cDNA encoding human motilin precursor (1987) (39)
Somatostatin-like Immunoreactivity in Human Peripheral Plasma Measured by Radioimmunoassay Following Affinity Chromatography (1981) (39)
Changes in heart rate in patients with type 2 diabetes mellitus after treatment with luseogliflozin: Subanalysis of placebo‐controlled, double‐blind clinical trials (2018) (39)
Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). (1997) (39)
Transgenic Rescue of Adipocyte Glucose-dependent Insulinotropic Polypeptide Receptor Expression Restores High Fat Diet-induced Body Weight Gain* (2011) (39)
Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. (2007) (38)
Beneficial effects of high protein diet in treatment of mild diabetes. (1983) (38)
Gallbladder Dynamics and Plasma Cholecystokinin Responses After Meals, Oral Water, or Sham Feeding in Healthy Subjects (1988) (38)
Sodium‐glucose cotransporter‐2 inhibitor luseogliflozin added to glucagon‐like peptide 1 receptor agonist liraglutide improves glycemic control with bodyweight and fat mass reductions in Japanese patients with type 2 diabetes: A 52‐week, open‐label, single‐arm study (2017) (38)
Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. (1998) (38)
The Insulinogenic Index in Secondary Diabetes (1975) (38)
Hypergastrinemia in hyperthyroidism. (1976) (38)
Type 2 diabetes via β-cell dysfunction in east Asian people. (2016) (38)
Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathy. (2001) (38)
The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. (1999) (37)
Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity. (2004) (36)
No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France (1999) (36)
Leptin in women with eating disorders. (1999) (36)
Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide (2006) (36)
Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release (2011) (36)
Impaired Glucose Sensitivity of ATP-Sensitive K+ Channels in Pancreatic β-cells in Streptozotocin-Induced NIDDM Rats (1992) (35)
Plasma insulin and glucagon responses to arginine in patients with thyroid dysfunction. (1974) (35)
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice (2009) (34)
Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men. (2006) (34)
Efficacy and Safety of the SGLT2 Inhibitor Luseogliflozin in Japanese Patients With Type 2 Diabetes Mellitus Stratified According to Baseline Body Mass Index: Pooled Analysis of Data From 52-Week Phase III Trials. (2016) (34)
Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway. (2000) (34)
Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release. (1993) (34)
Efficacy and safety of alogliptin added to sulfonylurea in Japanese patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial with an open‐label, long‐term extension study (2012) (33)
Safety, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Luseogliflozin Dosing in Healthy Japanese Males: A Randomized, Single-Blind, Placebo-Controlled Trial (2014) (33)
Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis. (2006) (33)
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism. (2009) (33)
Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic β-cells. (1998) (33)
Adrenomedullin promotes the epithelial restitution of rat and human gastric mucosa in vitro (1998) (32)
Characterization of glucose transporter in cultured human retinal pigment epithelial cells: gene expression and effect of growth factors. (1994) (32)
Regulation of Glucose-Transporter Gene Expression by Insulin in Cultured Human Fibroblasts (1988) (32)
Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr−/− Mice (2011) (32)
Predicting efficacy of dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: Association of glycated hemoglobin reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels (2012) (32)
Impaired metabolism-secretion coupling in pancreatic beta-cells: role of determinants of mitochondrial ATP production. (2007) (32)
Retrospective analysis of safety and efficacy of insulin‐to‐liraglutide switch in Japanese type 2 diabetes: A caution against inappropriate use in patients with reduced β‐cell function (2013) (32)
Multiple effector coupling of somatostatin receptor subtype SSTR1. (1994) (32)
Abnormal facilitative glucose transporter gene expression in human islet cell tumors. (1993) (31)
Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats. (2003) (31)
[Secondary forms of diabetes]. (1997) (31)
Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells. (2004) (31)
Alogliptin benzoate for the treatment of type 2 diabetes (2014) (31)
Efficacy and safety of alogliptin added to insulin in Japanese patients with type 2 diabetes: a randomized, double-blind, 12-week, placebo-controlled trial followed by an open-label, long-term extension phase (2014) (31)
Plasma Cholecystokinin and Pancreatic Polypeptide Response after Radical Pancreatoduodenectomy with Billroth I and Billroth II Type of Reconstruction (1987) (30)
Effects of ginseng radix on sugar absorption in the small intestine. (1999) (30)
Somatostatin Release from Isolated Perfused Rat Pancreas: Possible Role of Endogenous Somatostatin on Insulin Release (1979) (30)
Growth-Related Changes in Skeletal Muscle Fiber Type and Insulin Resistance in Diabetic Otsuka Long-Evans Tokushima Fatty Rats (2001) (29)
Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. (2006) (29)
Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia (2019) (29)
A Novel Glucokinase Regulator in Pancreatic β Cells (2001) (29)
Recovery of function and mass of endogenous beta-cells in streptozotocin-induced diabetic rats treated with islet transplantation. (2001) (29)
Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression. (2006) (28)
Src activation generates reactive oxygen species and impairs metabolism–secretion coupling in diabetic Goto–Kakizaki and ouabain-treated rat pancreatic islets (2008) (28)
Ventromedial Hypothalamic Lesions Increase Pancreatic Sensitivity to Streptozotocin in Rats (1980) (28)
Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides (2013) (28)
Glucagon‐like peptide‐1 analog liraglutide in combination with sulfonylurea safely improves blood glucose measures vs sulfonylurea monotherapy in Japanese patients with type 2 diabetes: Results of a 52‐week, randomized, multicenter trial (2011) (27)
Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets. (2002) (27)
The role of family nutritional support in Japanese patients with type 2 diabetes mellitus. (2010) (27)
Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation. (2010) (27)
Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia. (2005) (27)
A randomized dose-finding study demonstrating the efficacy and tolerability of albiglutide in Japanese patients with type 2 diabetes mellitus (2014) (27)
GLP-1 receptor agonists: targeting both hyperglycaemia and disease processes in diabetes. (2009) (27)
Safety and tolerability of empagliflozin in East Asian patients with type 2 diabetes: Pooled analysis of phase I–III clinical trials (2018) (27)
Pharmacodynamics of the glucagon-like peptide-1 receptor agonist lixisenatide in Japanese and Caucasian patients with type 2 diabetes mellitus poorly controlled on sulphonylureas with/without metformin (2014) (26)
Drug-Induced Generalized Skin Eruption in a Diabetes Mellitus Patient Receiving a Dipeptidyl Peptidase-4 Inhibitor Plus Metformin (2012) (26)
A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome (1986) (26)
Erythrocyte Sodium-Lithium Countertransport Activity as a Marker of Predisposition to Hypertension and Diabetic Nephropathy in NIDDM (1994) (26)
Glucose as Regulator of Glucose Transport Activity and Glucose-Transporter mRNA in Hamster β-Cell Line (1992) (25)
Effects of DPP‐4 inhibitor linagliptin and GLP‐1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: A randomized, open‐label, 2‐arm parallel comparative, exploratory trial (2016) (25)
Nestin-positive Cells in Adult Pancreas Express Amylase and Endocrine Precursor Cells (2005) (25)
The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice. (2011) (25)
Factors influencing the durability of the glucose‐lowering effect of sitagliptin combined with a sulfonylurea (2014) (25)
Effect of truncal vagotomy on pancreatic polypeptide response after intravenous glucose administration (1981) (24)
Effects of high protein diet on insulin and glucagon secretion in normal rats. (1982) (24)
Effects of sex, age and BMI on screening tests for impaired glucose tolerance. (2004) (24)
Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients. (2007) (24)
Luseogliflozin for the treatment of type 2 diabetes (2014) (24)
Fifty-two-week long-term clinical study of luseogliflozin as monotherapy in Japanese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise. (2015) (24)
Plasma motilin levels in normal subjects and patients with diabetes mellitus and certain other diseases. Fasting levels and responses to food and glucose. (1980) (23)
High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals. (2014) (23)
Identification and functional analysis of CBLB mutations in type 1 diabetes. (2008) (23)
Clock gene defect disrupts light-dependency of autonomic nerve activity. (2007) (23)
Effect of 1,25-dihydroxyvitamin D3 on pancreatic B and D cell function. (1983) (23)
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity. (1999) (23)
Troglitazone inhibits bicarbonate secretion in rat and human duodenum. (1999) (23)
Exon‐intron organization, expression, and chromosomal localization of the human motilin gene (1989) (22)
Hepatocyte Nuclear Factor-1 Recruits the Transcriptional CoActivator p 300 on the GLUT 2 Gene Promoter (2002) (22)
Characterization of circulating insulin in insulin autoimmune syndrome. (1986) (22)
Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease. (1997) (22)
Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose. (2000) (22)
Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release. (1980) (22)
Retrospective analysis of safety and efficacy of liraglutide monotherapy and sulfonylurea-combination therapy in Japanese type 2 diabetes: Association of remaining β-cell function and achievement of HbA1c target one year after initiation. (2015) (22)
Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. (1994) (22)
Efficacy and safety of sitagliptin as compared with glimepiride in Japanese patients with type 2 diabetes mellitus aged ≥ 60 years (START‐J trial) (2017) (21)
Self‐monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)‐treated type 2 diabetes (SMBG‐OHA study) (2013) (21)
Recent advances in motilin research: its physiological and clinical significance. (1978) (21)
Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation. (2003) (21)
Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic H+ concentration in pancreatic islets. (2006) (21)
Nisoldipine improves the impaired erythrocyte deformability correlating with elevated intracellular free calcium-ion concentration and poor glycaemic control in NIDDM. (1999) (21)
Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β‐cells (2011) (21)
Effects of streptozotocin-induced diabetes on circulating levels of vitamin D metabolites. (1983) (21)
Role of leptin in women with eating disorders. (1999) (21)
Incretin concept revised: The origin of the insulinotropic function of glucagon‐like peptide‐1 – the gut, the islets or both? (2017) (20)
Secretory units of islets in transplantation index is a useful clinical marker to evaluate the efficacy of sitagliptin in treatment of type 2 diabetes mellitus (2011) (20)
Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients. (2005) (20)
The polymorphism linked to the human insulin gene: its lack of association with either IDDM or NIDDM in Japanese. (1986) (20)
Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon (1998) (20)
Lifestyle changes as a result of COVID‐19 containment measures: Bodyweight and glycemic control in patients with diabetes in the Japanese declaration of a state of emergency (2021) (20)
Beneficial effect of long-term combined treatment with voglibose and pioglitazone on pancreatic islet function of genetically diabetic GK rats. (1998) (19)
Glucose-Dependent Insulinotropic Polypeptide Suppresses Peripheral Arterial Remodeling in Male Mice. (2018) (19)
Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: relationship with C-reactive protein and albuminuria. (2004) (19)
Selective impairment of the cytoplasmic Ca2+ response to glucose in pancreatic beta cells of streptozocin-induced non-insulin-dependent diabetic rats. (1993) (19)
Hypersecretion of gastric inhibitory polypeptide induced by glucose ingestion in diabetes mellitus. (1981) (19)
Dipeptidyl‐peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations (2012) (19)
GLP‐1 receptor agonist attenuates endoplasmic reticulum stress‐mediated β‐cell damage in Akita mice (2010) (19)
SUCCESSFUL TREATMENT OF METASTATIC GLUCAGONOMA WITH DACARBAZINE (1984) (19)
Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients. (2005) (19)
Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells. (1999) (19)
Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein in rat models of non-insulin-dependent diabetes mellitus. (1993) (19)
A cloned rat CD38-homologous protein and its expression in pancreatic islets. (1994) (19)
Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity (2019) (19)
Cardiovascular and renal effectiveness of empagliflozin in routine care in East Asia: Results from the EMPRISE East Asia study (2020) (18)
The role of endogenous gastric inhibitory polypeptide in the enteroinsular axis. (1982) (18)
Failure to Suppress Plasma Glucagon Concentrations by Orally Administered Glucose in Diabetic Patients After Treatment (1978) (18)
Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic beta-cells. (1998) (18)
Increased calcium-channel currents of pancreatic beta cells in neonatally streptozocin-induced diabetic rats. (1994) (18)
Circulating levels of tartrate-resistant acid phosphatase in rat models of non-insulin-dependent diabetes mellitus. (1998) (18)
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance (2015) (18)
Pharmacokinetics, Pharmacodynamics, and Safety of Luseogliflozin in Japanese Patients with Type 2 Diabetes Mellitus: A Randomized, Single-blind, Placebo-controlled Trial (2015) (18)
Liraglutide in Adults with Type 2 Diabetes: Global Perspective on Safety, Efficacy and Patient Preference (2011) (17)
The spontaneously diabetic Torii rat with gastroenteropathy. (2007) (17)
Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic islets (2006) (17)
Liraglutide is effective and well tolerated in combination with an oral antidiabetic drug in Japanese patients with type 2 diabetes: A randomized, 52‐week, open‐label, parallel‐group trial (2015) (17)
Glucagon-like peptide-1 receptor agonist therapeutics for total diabetes management: assessment of composite end-points (2015) (17)
Long-term safety of once-daily lixisenatide in Japanese patients with type 2 diabetes mellitus: GetGoal-Mono-Japan. (2015) (17)
Presence of autoantibodies to carbonic anhidrase II and lactoferrin in type 1 diabetes: proposal of the concept of autoimmune exocrinopathy and endocrinopathy of the pancreas. (2001) (17)
Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes patients: The association between remaining β‐cell function and the achievement of the glycated hemoglobin target 1 year after initiation (2017) (17)
Motilin release by intravenous infusion of nutrients and somatostatin in conscious dogs (1981) (17)
Sodium glucose co-transporter 2 inhibitor luseogliflozin in the management of type 2 diabetes: a drug safety evaluation (2017) (17)
Changes in insulin, somatostatin, and glucagon secretion during the development of obesity in ventromedial hypothalamic-lesioned rats. (1984) (16)
Suppressive effects of polygonati rhizoma on hepatic glucose output, GLUT2 mRNA expression and its protein content in rat liver. (1994) (16)
Alteration of plasma glucagon response to arginine after treatment in patients with diabetes mellitus, cushing's syndrome and hypothyroidism. (1977) (16)
Short-term intensive glycemic control improves vibratory sensation in type 2 diabetes. (2008) (16)
IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia. (2004) (16)
Hypogastrinemia in hypothyroidism (1978) (16)
Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice. (2019) (16)
Somatostatin, insulin, and glucagon secretion from isolated perfused pancreas of obese rats. (1981) (16)
The failure of truncal vagotomy to affect motilin release in dogs. (1985) (15)
Factors responsible for elevation of 1-h postchallenge plasma glucose levels in Japanese men. (2008) (15)
Relationship between deterioration of glycated hemoglobin‐lowering effects in dipeptidyl peptidase‐4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes (2017) (15)
Glycemic instability in type 1 diabetic patients: Possible role of ketosis or ketoacidosis at onset of diabetes. (2008) (15)
Antidiabetic effect of seishin-kanro-to in KK-Ay mice. (1997) (15)
Changes in glucose transporter 2 and carbohydrate-metabolizing enzymes in the liver during cold preservation and warm ischemia. (1996) (15)
Modulation by AUoxan of Glucagon and Insulin Secretion in the Isolated Perfused Rat Pancreas (1978) (15)
GPR 119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (2010) (15)
Effect of probucol on serum lipids and apoproteins in patients with noninsulin-dependent diabetes mellitus (1987) (15)
Defining the role of GLP-1 receptor agonists for individualized treatment of Type 2 diabetes (2014) (15)
Theophylline: Potentiation of Arginine-induced Somatostatin Release from the Isolated Rat Pancreas (1979) (14)
GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis. (2008) (14)
Treat-to-target comparison between once daily biphasic insulin aspart 30 and insulin glargine in Chinese and Japanese insulin-naïve subjects with type 2 diabetes (2013) (14)
Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets. (1999) (14)
Effects of insulin on altered mineral and vitamin D metabolism in streptozotocin-induced diabetes. (1985) (14)
The once‐daily human glucagon‐like peptide‐1 analog, liraglutide, improves β‐cell function in Japanese patients with type 2 diabetes (2012) (14)
Soluble tumor necrosis factor receptor 1 is strongly and independently associated with serum homocysteine in nonobese Japanese type 2 diabetic patients. (2006) (14)
Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs. (1997) (14)
Metabolic syndrome, insulin resistance, and atherosclerosis in Japanese type 2 diabetic patients. (2007) (14)
Effects of prostaglandin E2 and D2 on gastric somatostatin and gastrin secretion (1983) (14)
Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice. (2009) (14)
Effect of acarbose (alpha-glucosidase inhibitor) on disaccharase activity in small intestine in KK-Ay and ddY mice. (1998) (14)
A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activity. (2001) (14)
Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. (2005) (14)
Effect of polygonati rhizoma on blood glucose and facilitative glucose transporter isoform 2 (GLUT2) mRNA expression in Wistar fatty rats. (1995) (13)
Adult pancreatic islets require differential pax6 gene dosage. (2007) (13)
Analysis of factors influencing postprandial C‐peptide levels in Japanese patients with type 2 diabetes: Comparison with C‐peptide levels after glucagon load (2011) (13)
Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro (1992) (13)
The role of the beta-adrenergic mechanism in the hypergastrinemia of hyperthyroidism. (1980) (13)
Effects of glycyrrhizin (SNMC: stronger Neo-Minophagen C) in hemophilia patients with HIV infection. (1989) (13)
ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca2+-depleted condition. (2005) (13)
Effect of pancreas transplantation on decreased levels of circulating bone gamma-carboxyglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes. (1992) (13)
Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes. (2013) (13)
ABNORMAL PANCREATIC POLYPEPTIDE RESPONSE TO ORAL GLUCOSE LOADING IN DIABETES MELLITUS (1980) (13)
Improvement of Fasting Plasma Glucose Level After Ingesting Moderate Amount of Dietary Fiber in Japanese Men With Mild Hyperglycemia and Visceral Fat Obesity (2013) (13)
Gender Difference in ICER Iγ Transgenic Diabetic Mouse (2007) (12)
Effects of Okadaic Acid on Rat Colon (1998) (12)
Therapeutic Effect of Basic Fibroblast Growth Factor on Experimental Pancreatitis in Rat (2000) (12)
Effects of naloxone on basal and vagus nerve-induced secretions of GRP, gastrin, and somatostatin from the isolated perfused rat stomach. (1987) (12)
Soluble tumor necrosis factor receptor 2 is independently associated with pulse wave velocity in nonobese Japanese patients with type 2 diabetes mellitus. (2007) (12)
The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells. (1998) (12)
Effect of glucocorticoids on gastrin secretion in man. (1978) (12)
Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents. (2005) (12)
Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. (2008) (12)
Understanding the incretin effect. (2011) (12)
Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters. (2002) (12)
Modulation by alloxan of glucagon and insulin secretion in the isolated perfused rat pancreas. (1978) (12)
Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors. (2018) (11)
Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets. (2001) (11)
Comparative insulinogenic effects of glucose, arginine and glucagon in patients with diabetes mellitus, endocrine disorders and liver disease (1975) (11)
Influence of water-immersion stress on synthesis of mucus glycoprotein in the rat gastric mucosa. (1989) (11)
Effect of the α2-blocker DG-5128 on insulin and somatostatin release from the isolated perfused rat pancreas (1987) (11)
Increased circulating levels of γ-carboxyglutamic acid-containing protein and decreased bone mass in children on anticonvulsant therapy (1989) (11)
Efficacy and safety of lixisenatide in Japanese patients with type 2 diabetes mellitus inadequately controlled by sulfonylurea with or without metformin: Subanalysis of GetGoal-S (2014) (11)
Cardiovascular outcomes and safety with linagliptin, a dipeptidyl peptidase‐4 inhibitor, compared with the sulphonylurea glimepiride in older people with type 2 diabetes: A subgroup analysis of the randomized CAROLINA trial (2020) (11)
A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement. (2006) (11)
Absence of Drug–Drug Interactions Between Luseogliflozin, a Sodium–Glucose Co-transporter-2 Inhibitor, and Various Oral Antidiabetic Drugs in Healthy Japanese Males (2015) (11)
Availability of plasma pancreatic polypeptide measurement in diagnosis of chronic pancreatitis. (1981) (11)
Impaired Plasma Insulin Response to Arginine in Hyperthyroidism: Important Role of the Rise of Blood Glucose in the Second Phase of Insulin Release Induced by Arginine (1976) (11)
Cardiovascular and kidney outcomes of linagliptin treatment in older people with type 2 diabetes and established cardiovascular disease and/or kidney disease: A prespecified subgroup analysis of the randomized, placebo‐controlled CARMELINA® trial (2020) (11)
Role of the duodenum in motilin release (1981) (11)
Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetic GK rats and its defective augmentation by glucose (1995) (11)
Evaluation of skeletal muscle mass indices, assessed by bioelectrical impedance, as indicators of insulin resistance in patients with type 2 diabetes (2019) (11)
Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label period (2018) (11)
Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. (1999) (11)
A comparative study of high-fat diet containing fish oil or lard on blood glucose in genetically diabetic (db/db) mice. (1997) (11)
Efficacy and Safety of Lixisenatide in Japanese Patients with Type 2 Diabetes Insufficiently Controlled with Basal Insulin±Sulfonylurea: A Subanalysis of the GetGoal-L-Asia Study (2015) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Effects of glucagon‐like peptide‐1 receptor agonists on secretions of insulin and glucagon and gastric emptying in Japanese individuals with type 2 diabetes: A prospective, observational study (2021) (10)
Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. (1980) (10)
Bombesin inhibits insulin release from isolated pancreatic islets of rats in vitro. (1978) (10)
A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes (2020) (10)
Glutamate is an essential mediator in glutamine‐amplified insulin secretion (2021) (10)
Insulin secretory capacity and insulin sensitivity in impaired fasting glucose in Japanese (2012) (10)
The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. (2003) (10)
Effect of antisomatostatin gamma-globulin on gastrin release in rats. (1981) (10)
Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo. (2013) (10)
Antidiabetic mechanism of Bakumondo-inshi. (1999) (10)
Incretin hormone receptors are required for normal beta cell development and function in female mice (2016) (10)
Luseogliflozin, a sodium-glucose cotransporter 2 inhibitor, preserves renal function irrespective of acute changes in the estimated glomerular filtration rate in Japanese patients with type 2 diabetes (2020) (10)
A case of hypoglycemia due to illegitimate sexual enhancement medication. (2015) (10)
The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes (2014) (10)
Effect of truncal vagotomy on GIP release induced by intraduodenal glucose or fat in dogs. (1985) (10)
Elevated Erythrocyte Sodium–lithium Countertransport Activity Correlates with Increased Intracellular Sodium and Free Calcium‐ion Concentration in Type 2 Diabetes (1996) (10)
Gastric mucosal damage caused by monochloramine in the rat and protective effect of taurine: endoscopic observation through gastric fistula. (2000) (9)
Cardiovascular safety trials of incretin‐based drugs: What do they mean? (2016) (9)
Effect of mangiferin with exercise in early stage symptom of type 2 diabetic mice (2000) (9)
[Somatostatin and its receptors]. (1996) (9)
GLP-1 receptor signaling differentially modifies the outcomes of sterile vs. viral pulmonary inflammation in male mice. (2020) (9)
Renal tubular disturbances induced by tributyl-tin oxide in guinea pigs: a secondary Fanconi syndrome. (1984) (9)
Osteopenia and circulating levels of vitamin D metabolites in diabetes mellitus. (1985) (8)
GREATER COMBINED REDUCTIONS IN HBA1C ≥1.0% AND WEIGHT ≥5.0% WITH SEMAGLUTIDE VS COMPARATORS IN TYPE 2 DIABETES. (2019) (8)
Why Are Incretin-Based Therapies More Efficient in East Asians? Perspectives from the Pathophysiology of Type 2 Diabetes and East Asian Dietary Habits (2015) (8)
Reduced sensitivity of dihydroxyacetone on ATP-sensitive K+ channels of pancreatic beta cells in GK rats (1994) (8)
Insulin binding to erythrocytes in diabetic patients. (1981) (8)
Effect of starvation of gastric somatostatin release. (1981) (8)
Randomized controlled trial of single‐agent glimepiride and pioglitazone in Japanese patients with type 2 diabetes: A comparative study (2011) (8)
Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice. (2004) (8)
Effector coupling of somatostatin receptor subtypes on human endocrine tumors. (1996) (8)
Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week open-label extension (2017) (8)
Hyperfunction of the entero-PP axis in non-insulin dependent diabetes mellitus. (1983) (8)
Mental distress and health‐related quality of life among type 1 and type 2 diabetes patients using self‐monitoring of blood glucose: A cross‐sectional questionnaire study in Japan (2018) (8)
Autoantibodies against the exocrine pancreas in fulminant type 1 diabetes. (2005) (8)
Glucose regulation of arginine-induced pancreatic somatostatin release from the isolated perfused rat pancreas (1982) (8)
Effect of acetylsalicylic acid on blood glucose and glucose regulatory hormones in mild diabetes. (1982) (8)
Pharmacokinetics and Pharmacodynamics of Luseogliflozin, a Selective SGLT2 Inhibitor, in Japanese Patients With Type 2 Diabetes With Mild to Severe Renal Impairment (2018) (8)
Early and late onset side effects of short-acting insulin analogue in seven Japanese diabetic patients. (2007) (8)
Short term effects of glucose and arginine on the preproinsulin messenger ribonucleic acid level in the perfused rat pancreas: comparison with insulin secretion. (1989) (8)
Effects of oral glucose administration on preproinsulin mRNA in rats in vivo. (1986) (7)
Rationale and design of the EMPA-ELDERLY trial: a randomised, double-blind, placebo-controlled, 52-week clinical trial of the efficacy and safety of the sodium–glucose cotransporter-2 inhibitor empagliflozin in elderly Japanese patients with type 2 diabetes (2021) (7)
Aspartame-Acesulfame K-containing Low-Energy Erythritol Sweetener Markedly Suppresses Postprandial Hyperglycemia in Mild and Borderline Diabetics (2010) (7)
Prostaglandin E1: stimulation of somatostatin and insulin responses to glucose from the isolated perfused rat pancreas. (1982) (7)
Therapeutic inertia or individualization? Delay in clinical management of type 2 diabetes mellitus (2016) (7)
Dipeptidyl peptidase‐4 inhibitors and prevention of bone fractures: Effects beyond glyemic control (2012) (7)
Ouabain suppresses ATP elevation in response to fuel secretagogues in pancreatic islets. (1998) (7)
Enhanced Bioavailability of Subcutaneously Injected Insulin Coadministered with Collagen in Rats and Humans (1989) (7)
Insuppressibility of plasma glucagon by orally or intravenously administered glucose in diabetes mellitus. (1977) (7)
Different effects of prostaglandin E1, E2 and D2 on pancreatic somatostatin release. (2008) (7)
The Urinary Concentration of Sialic Acid is Increased in Non‐insulin‐dependent Diabetic Patients with Microangiopathy: a Possible Useful Marker for Diabetic Microangiopathy (1995) (7)
Evaluation of the efficacy and safety of lixisenatide add-on treatment to basal insulin therapy among T2DM patients with different body mass indices from GetGoal trials (2015) (7)
Safety, tolerability and efficacy of lixisenatide as monotherapy in Japanese patients with type 2 diabetes mellitus: An open‐label, multicenter study (2017) (7)
Factors responsible for glucose intolerance in Japanese subjects with impaired fasting glucose. (2007) (7)
Cigarettes smoking inhibits arginine-induced insulin release in man. (1978) (7)
Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway (2021) (7)
Possible role of the duodenum in the entero-PP axis (1983) (6)
[New diagnostic criteria for diabetes in Japan]. (2010) (6)
Diabetic osteopenia in central Japan. (1985) (6)
Real-world Observational Study on Patient Outcomes in Diabetes (RESPOND): study design and baseline characteristics of patients with type 2 diabetes newly initiating oral antidiabetic drug monotherapy in Japan (2020) (6)
Effects of antisomatostatin and antiglucagon sera on insulin release from isolated Langerhans' islets of rats. (1981) (6)
The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice (2020) (6)
Soluble Tumor Necrosis Factor Receptor 2 Is Independently Associated With Brachial-Ankle Pulse-Wave Velocity in Nonobese Japanese Type 2 Diabetic Patients (2006) (6)
The Association between Trp 64 Arg Polymorphism of the b 3 -Adrenergic Receptor and Autonomic Nervous System Activity* (1999) (6)
The journey to understanding incretin systems: Theory, practice and more theory (2019) (6)
Poor correlation of pulse-wave velocity and intima-media thickness in diabetic subjects. (2004) (6)
Increase in liver glucose transporter mRNA levels during rat liver regeneration. (1990) (6)
Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index (2022) (6)
Inhibition of GIP signaling extends lifespan without caloric restriction. (2019) (6)
Efficacy and safety of adding liraglutide to existing insulin regimens in Japanese patients with type 2 diabetes mellitus: A post‐hoc analysis of a phase 3 randomized clinical trial (2018) (6)
Genetic variation in the hepatocyte nuclear factor (HNF)-3alpha gene does not contribute to maturity-onset diabetes of the young in Japanese. (2001) (5)
Effect of vitamin D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach. (1988) (5)
Effect of starvation on somatostatin content of pancreas and gastrointestinal tract of the guinea pig. (1982) (5)
Effect of truncal vagotomy on intestinal phase of pancreatic polypeptide release in dogs (1985) (5)
BS2-A Relevance of incretins in the treatment of Asian patients with Type 2 diabetes (2008) (5)
Effect of glucagon antiserum on somatostatin, glucagon and insulin release from the isolated perfused rat pancreas (1982) (5)
Determination of hemoglobin A1C in normal and diabetic mice: neonatal streptozotocin-induced diabetic mice and KK-Ay mice. (1996) (5)
Amino acid modulation of glucose-induced insulin and glucagon release in diabetic patients. (1977) (5)
[Effect of mazindol on insulin and glucagon secretion in ventromedial hypothalamic obese rats]. (1985) (5)
Triiodothyronine Immunoassay Using Polyethylene Glycol to Precipitate Antibody-Bound Hormone (1978) (5)
Comparison of somatostatin-28 and somatostatin-14 clearance by the perfused rat liver. (1985) (5)
Alogliptin for the treatment of type 2 diabetes: a drug safety evaluation (2016) (5)
The effect of ventromedial hypothalamic nuclei destruction on somatostatin and insulin release from the isolated perfused rat pancreas. (1981) (5)
Circulating levels of vitamin D metabolites in patients with hyperinsulinaemia. (1984) (5)
Somatostatin, glucagon, and insulin secretion from isolated perfused pancreas of new genetically obese hyperglycemic rats. (1984) (5)
OP72 COMBINATION THERAPY WITH LIRAGLUTIDE AND INSULIN IN JAPANESE SUBJECTS WITH TYPE 2 DIABETES: THE LIRA-ADD2INSULIN JAPAN TRIAL (2014) (5)
Altered Functions of Ion Channels in Diabetic β Cells (1995) (5)
The Incretin Effect in Female Mice With Double Deletion of GLP-1 and GIP Receptors (2019) (5)
Fructose: inhibition of glucagon and stimulation of insulin responses to arginine in the isolated perfused rat pancreas. (1976) (4)
Yokoi, N. et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat. Genet. 31, 391-394 (2002) (4)
Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons (2021) (4)
Safety and efficacy of the combination of the glucagon‐like peptide‐1 receptor agonist liraglutide with an oral antidiabetic drug in Japanese patients with type 2 diabetes: Post‐hoc analysis of a randomized, 52‐week, open‐label, parallel‐group trial (2017) (4)
Insulin glargine in pediatric patients with type 1 diabetes in Japan (2014) (4)
Ninjin'yoeito Targets Distinct Ca2+ Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus (2020) (4)
Comparative effect of somatostatin-14 and somatostatin-28 on glucagon-induced glycogenolysis from the perfused rat liver. (1988) (4)
Safety and Tolerability of Empagliflozin in East Asian Patients with Type 2 Diabetes—Pooled Analysis of Phase I-III Clinical Trials (2018) (4)
Islet adaptation in GIP receptor knockout mice (2020) (4)
[Evaluation of extraction methods of plasma somatostatin]. (1983) (4)
Albiglutide, a weekly GLP-1 receptor agonist, improves glycemic parameters in Japanese patients with type 2 diabetes over 1 year when added to single oral antidiabetic drugs (2017) (4)
Evaluation of large‐scale clinical trials on cardiovascular disease risk in patients with type 2 diabetes mellitus treated with dipeptidyl peptidase 4 inhibitors and a new class of drugs (2017) (4)
Safety, tolerability and efficacy of lixisenatide in combination with oral antidiabetic treatment in Japanese patients with type 2 diabetes: An open‐label, multicenter study (2017) (4)
Healthcare resource utilization in patients treated with empagliflozin in East Asia (2021) (4)
A case of insulinoma with non-alcoholic fatty liver disease: Roles of hyperphagia and hyperinsulinemia in pathogenesis of the disease. (2015) (4)
[Natural history of type 2 diabetes mellitus]. (2012) (4)
Xylitol: stimulation of insulin and inhibition of glucagon responses to arginine in man. (1976) (4)
Necessity of endogenous GTP derived from glucose-6-phosphate for insulin secretion augmented by glucose under protein kinase A activation. (1998) (4)
(3-ii) Significance of the Measurement of Plasma Insulin and Glucagons in the Diagnosis of Diabetes Mellitus (1977) (4)
Solid‐phase extraction treatment is required for measurement of active glucagon‐like peptide‐1 by enzyme‐linked immunosorbent assay kit affected by heterophilic antibodies (2018) (4)
Actual condition survey regarding mismatch of measurements between radioimmunoassay and enzyme‐linked immunosorbent assay tests for anti‐glutamic acid decarboxylase antibody in real‐world clinical practice (2018) (4)
Cost of Medical Care of Type 2 Diabetes Mellitus Outpatients : Effect of Healthcare Reform on the Diabetes Clinic (2005) (4)
Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit. (2000) (4)
Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice (2017) (4)
Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets. (2001) (4)
The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice (2021) (3)
Potentiation by theophylline of arginine-induced glucagon secretion in the isolated perfused rat pancreas. (1976) (3)
The effect of aminoguanidine, an inos-selective NOs inhibitor, on TNB colitis (1998) (3)
Blood glucose and plasma insulin of mild diabetic patients in response to high protein divided meals. (1983) (3)
PvuII polymorphic sites in the human insulin receptor gene INSR. (1986) (3)
THE EVIDENCE FOR THE REGULATORY ROLE OF ENDOGENOUS GIP AS A GLUCOSE DEPENDENT INSULINOTROPIC HORMONE IN PATIENTS WITH DUODENAL ULCER (1983) (3)
Effect of adrenergic blocking agents on plasma gastrin and secretin levels in man. (1980) (3)
A randomized, placebo‐controlled study to evaluate the efficacy and safety of adding omarigliptin to insulin therapy in Japanese patients with type 2 diabetes and inadequate glycaemic control (2021) (3)
Vagal modulation of arginine- and glucagon-induced pancreatic somatostatin secretion. (1985) (3)
A case of fulminant type 1 diabetes associated with painless thyroiditis. (2006) (3)
Detection of Antibodies against Wheat Germ Agglutinin Bound Glycoproteins on the Islet‐cell Membrane (1988) (3)
Disopyramide and Its Metabolite Enhance Insulin Release from Clonal Pancreatic β-Cells by Blocking KATP Channels (2004) (3)
Relationship and factors responsible for regulating fasting and post-challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus (2014) (3)
Inhibition by mannose of arginine-induced glucagon secretion in the isolated perfused rat pancreas. (1977) (3)
Effect of epinephrine on GLUT2 protein content in mouse liver. (2000) (3)
Weekly glucagon‐like peptide‐1 receptor agonist albiglutide as monotherapy improves glycemic parameters in Japanese patients with type 2 diabetes mellitus: A randomized, double‐blind, placebo‐controlled study (2017) (3)
Gender difference in ICER Igamma transgenic diabetic mouse. (2007) (3)
PRESENCE OF LOW MOLECULAR WEIGHT LIPOPROTEINS IN CORD SERUM DEMONSTRATED BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) (1989) (3)
Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats. (2003) (2)
d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice (2022) (2)
Endocrine disorders and diabetes in Japan. (1994) (2)
Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes and inadequate glycaemic control on sitagliptin (2021) (2)
Issue Information (2018) (2)
Efficacy and safety of oral semaglutide by baseline age in Japanese patients with type 2 diabetes: A subgroup analysis of the PIONEER 9 and 10 Japan trials (2021) (2)
Association of serum resistin with TNF system activity in Japanese type 2 diabetic patients. (2007) (2)
Type-1 diabetes mellitus with insufficient serum immunoreactive insulin elevation after subcutaneous NPH-insulin injection. (2003) (2)
Cerulein-induced pancreatic polypeptide secretion. Its inhibition by atropine and its possible role in regulating gallbladder relaxation. (1980) (2)
Effect of DG5128 on epinephrine and glucagon induced glucose output from the isolated perfused rat liver. (1988) (2)
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion. (2008) (2)
[Standardization for evaluation of plasma cyclic AMP response in Ellsworth-Howard test]. (1982) (2)
A novel RFX6 heterozygous mutation (p.R652X) in maturity‐onset diabetes mellitus: A case report (2021) (2)
The role of vitamin D metabolites in hypercalcemia of Zucker fa/fa rats. (1985) (2)
[Multiple risk factor syndrome]. (1999) (2)
C-TERMINAL PEPTIDE OF THE GIP PRECURSOR AND PANCREASTATIN FRAGMENTS ON INSULIN SECRETION FROM ISOLATED RAT ISLETS (1990) (2)
Reply to the comment of Wilbrink et al. on Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β‐cell function and the achievement of the HbA1c target 1 year after initiation (2018) (2)
A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5) (2020) (2)
Human TSC-22 gene: no association with type 2 diabetes. (2001) (2)
THE MECHANISM OF VAGAL CONTROL IN HYPOGLYCEMIA-INDUCED PANCREATIC POLYPEPTIDE SECRETION (1981) (2)
Reversal of osteopenia in streptozotocin diabetic rats by pancreatic transplantation. (1985) (2)
[Pancreatic polypeptide (PP)]. (1995) (2)
Use of the insulin sensitivity index obtained from oral glucose tolerance test in Japanese subjects. (2001) (2)
The effect of NOsinhibitors on the TNB colitis: A comparative study (1998) (2)
Regulation of glucose metabolism and opening of K(ATP) channels in pancreatic beta-cells by NO. (1997) (2)
The possible role of the duodenum in an entero-PP axis (1980) (1)
Hind III site causing Proinsulin Kyoto and Pst I site polymorphism of the insulin gene in Japanese: its lack of association with either IDDM or NIDDM. (1994) (1)
Effects of Dietary Instructions Including Meal-Sequence for Prediabetes Subjects—Comparison with Conventional Approach (2018) (1)
Gastric Inhibitory Polypeptide: Structure and ChromosomalLocalization of the Human Gene (2008) (1)
Effect of antithyroid autoantibodies on pancreatic islet-cell function (2007) (1)
Association of dipeptidyl peptidase‐4 inhibitor use and risk of pancreatic cancer in individuals with diabetes in Japan (2022) (1)
Effect of thromboxane A2 receptor antagonist(ONO-NT-126) on an animal model of inflammatory bowel disease (1995) (1)
A Genetic non-insulin dependent diabetic mice, KK-Ay mice, is elevated alpha-glucosyldisaccharide digestive/absorptive capacity in small intestine (1998) (1)
Efficacy and safety comparison of sitagliptin and glimepiride in elderly Japanese patients with type 2 diabetes: START-J (2016) (1)
Effect of the alpha 2-blocker DG-5128 on insulin and somatostatin release from the isolated perfused rat pancreas. (1987) (1)
Divergent Relationships Among Soluble Tumor Necrosis Factor-Receptors 1 and 2 (2006) (1)
[Microalbuminuria in patients with impaired glucose tolerance]. (2005) (1)
PO046 COMPARISON OF FISH OR MEAT INTAKE BEFORE AND AFTER RICE ON POSTPRANDIAL GLUCOSE EXCURSIONS AND INCRETIN SECRETION IN TYPE 2 DIABETES: MEAL-SEQUENCE AS A NOVEL TARGET IN DIETARY THERAPY FOR DIABETES (2014) (1)
[Genetic factors and insulin resistance]. (2000) (1)
Once-Daily Lixisenatide in Combination with Basal Insulin ± Oral Antihyperglycemic Agents in Patients with Type 2 Diabetes Selectively Reduces Postprandial Hyperglycemic Daytime Exposure (2013) (1)
Effect of 5-Hydroxytryptophan (5-HTP), L-DOPA and Bethanidine on Plasma Insulin Response to Intravenous Glucose Loading in Normal Subjects (1975) (1)
[The detection of GLUT2 gene mutation by polymerase-chain reaction single stranded conformation polymorphism (PCR-SSCP) method]. (1994) (1)
[Prevention of alcohol-induced gastric mucosal injury by prostaglandin E-1]. (1990) (1)
[Obesity and bone metabolism]. (2004) (1)
Responder Analysis of Subjects Achieving HbA1c ≥1% and Weight Loss ≥5% Across SUSTAIN 1–5 Clinical Trials (2017) (1)
CARDIOVASCULAR EFFECTIVENESS OF EMPAGLIFLOZIN COMPARED TO DPP4I IN ROUTINE CARE IN EAST ASIA: RESULTS FROM THE EMPRISE STUDY (2021) (1)
[Insulin gene: gene organization and its regulatory mechanism of transcription]. (1997) (1)
[The regulation of insulin gene transcription by transcription factors]. (2002) (1)
Soluble TNF receptor and periodontal disease in non-obese Japanese type 2 diabetic patients. (2006) (1)
The Asian Association for the Study of Diabetes (2010) (1)
[Gastric inhibitory polypeptide (GIP) and GIP receptor (GIPR)]. (1996) (1)
Role of Triglyceride, Adiponectin, and Body Mass Index in Identifying Insulin Resistance in Japanese Isolated Impaired Glucose Tolerance Male Subjects (2011) (1)
[MHC class II antigen and other genes in NIDDM]. (1991) (1)
The Role of Glucocorticoids in the Regulation of Plasma Glucose, Insulin and Glucagon in Sheep (1987) (1)
Safet and tolerability, pharmacokinetic and spharmacodynamics of albiglutide in Japanese subjects with type 2 diabetes: a comparison with an ethnically mixed population (2009) (1)
[Physiopathology and etiological mechanism involving type 2 diabetes mellitus]. (2004) (1)
Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: association with atherosclerosis. (2007) (1)
Original article Efficacy andsafety ofluseogliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: a 12-week, randomized, placebo-controlled, phase II study (2014) (1)
Use of the Japanese health insurance claims database to assess safety of SGLT2 inhibitors in the management of diabetes (2016) (1)
Nisoldipine blocks the increase of intracellular free calcium‐ion concentration associated with elevated sodium–lithium countertransport activity in erythrocytes in patients with NIDDM (1997) (1)
[Heterogeneity in pathogenesis of NIDDM and recent advances in research of diabetogenic genes]. (1994) (1)
Plasma Glucagon Responses to Oral Glucose Loading in Gastrectomized Rats (1978) (1)
[Differential diagnosis of hypoparathyroid disorders during childhood by plasma cyclic AMP assay (author's transl)]. (1979) (1)
Alteration of plasma insulin and glucagon responses to arginine in diabetic rats with pancreas isografts (1978) (1)
[Candidate gene approach in Japanese NIDDM: liver/pancreatic beta cell type glucose transporter (GLUT2)]. (1994) (1)
Altered functions of ion channels in diabetic beta cells. (1995) (1)
Stigma evaluation for diabetes and other chronic non‐communicable disease patients: Development, validation and clinical use of stigma scale – The Kanden Institute Stigma Scale (2022) (1)
Degradation and conversion of somatostatin in normal and diabetic rats in vivo and in vitro. (1988) (1)
1019-P: Glucagon-Like Peptide-1 Receptor Agonists Predominantly Reduce Body Fat Mass in Patients with Type 2 Diabetes (2019) (1)
CHANGES IN THE PLASMA TRIGLYCERIDE AND APOPROTEIN E LEVEL DURING ORAL GLUCOSE LOADING IN NORMAL SUBJECTS AND IN PATIENTS WITH DIABETES MELLITUS (1991) (0)
Comparative study of SS-14 and SS-28 on pancreatic hormone secretion and hepatic clearance in stz diabetes (1984) (0)
Vagal regulation of gastric and pancreatic somatostatin secretion in vitro. (1984) (0)
Original diabetes education program including individual self-care plan “My Goals Sheet” ameliorates long-term glycemic control in patients with diabetes mellitus (2016) (0)
[Radioimunoassay with a new somatostatin antiserum--experimental studies]. (1978) (0)
Effects of physician’s diabetes self‐management education using Japan Association of Diabetes Education and Care Diabetes Education Card System Program and a self‐monitoring of blood glucose readings analyzer in individuals with type 2 diabetes: An exploratory, open‐labeled, prospective randomized c (2021) (0)
[Clinical picture and hormonal changes in diabetes mellitus]. (1976) (0)
Drucker Receptor-Dependent and Independent Mechanisms GPR 119 Regulates Murine Glucose Homeostasis Through Incretin (2011) (0)
Issue Information (2018) (0)
Research of Anaerobic Threshold in Male with Type 2 Diabetes Mellitus with High Homeostasis Model Assessment of Insulin Resistance (2019) (0)
Islets-activating protein from Bordetella pertussis: enhancement of pancreatic somatostatin release. (1983) (0)
Effect of epalrestat on impairment of colonic contractile activity and ion transport in streptozotocin-induced diabetic rats (2000) (0)
[Functions of intestinal peptides and disorders caused by their irregular secretion]. (1984) (0)
Corrigendum (2015) (0)
Abstracts of Strategy Against Diabetes Mellitus in Asia (2010) (0)
[The alpha 1 subunit of voltage-dependent calcium channel expressed in pancreatic beta cells]. (1994) (0)
Autonomic regulation of pancreatic and gastric hormone secretion. (1989) (0)
[Abnormal sugar metabolism in diseases of mesencephalon and pituitary gland]. (1982) (0)
[Organization of the human GLUT2 gene and regulation of the GLUT2 gene expression]. (1994) (0)
Factors Responsible for Progression of Microalbuminuria in Japanese Patients with Type 2 Diabetes-Retrospective Analysis (2018) (0)
HLA phenotypes of IDDM among nan nationality in northeastern China (1987) (0)
Deterioration of HbA1c-Lowering Effects in Dipeptidyl-Peptidase Inhibitor and Dietary Habits in Japanese Type 2 Diabetes—Comparison with That of Metformin (2018) (0)
[Symposium on the diagnosis of diabetes mellitus. (3)-ii) Significance of the measurement of plasma insulin and glucagon in the diagnosis of diabetes mellitus (author's transl)]. (1977) (0)
Motilin: Structure, Expression, and Chromosomal Localization of Human Gene (1991) (0)
[Availability of plasma human pancreatic polypeptide measurement in chronic pancreatitis (author's transl)]. (1979) (0)
786-P: Serum Dehydroepiandrosterone Sulfate Concentration and Animal Protein Intakes Are Important Factors for Skeletal Muscle Mass in Japanese Patients with Type 2 Diabetes (2019) (0)
PO426 EFFICACY AND SAFETY OF LUSEOGLIFLOZIN IN VARIOUS LEVELS OF RENAL FUNCTION IN JAPANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS: ANALYSIS OF POOLED DATA FROM LONG-TERM PHASE 3 TRIALS (2014) (0)
EFFECTS OF VAGOTOMY ON THE ENDOCRINE PANCREAS (1980) (0)
Title GLP-1 receptor agonist attenuates endoplasmic reticulumstress-mediated β-cell damage in Akita mice (2016) (0)
Title Insulin secretory defect and insulin resistance in isolated impaired fasting glucose and isolated impaired glucose tolerance (2018) (0)
[Pancreatic polypeptide (PP)]. (1995) (0)
Endocrine function of pancreas transplant: Insulin, glucagon and somatostatin release from rat pancreatic isograft (1982) (0)
[Secretory mechanism of pancreatic polypeptide]. (1980) (0)
[Prospects for incretin-related drugs]. (2012) (0)
P-37 Usefulness of C-peptide value for estimating pancreatic β-cell function: Application to the assessment of insulin therapy for Type 2 diabetes (2008) (0)
[Gastrointestinal hormones in diabetes mellitus]. (1997) (0)
Issue Information (2016) (0)
[Reactions of CPR during various stimulatory tests and its characteristics in hypoglycemia]. (1977) (0)
[Glucose transporters--their abnormalities and significance in disease states]. (1993) (0)
926-P: Cardiovascular (CV) and Hypoglycemia Outcomes across Age Groups in People with Type 2 Diabetes (T2D) in the CAROLINA Trial (2020) (0)
Issue Information (2018) (0)
SUPPRESSIBILITY OF PLASMA MOTILIN BY ORALLY ADMINISTERED GLUCOSE IN PATIENTS WITH HYPERTHYROIDISM AND LIVER CIRRHOSIS (1980) (0)
1734-P: A Considerable Mismatch of Measurements between Radioimmunoassay and Enzyme-Linked Immunosorbent Assay Tests for Anti-Glutamic Acid Decarboxylase Antibody (2019) (0)
Organizing Committee and International Advisory Board (2012) (0)
PO059 COMPARISON OF POST-EXERCISE GLUCOSE EXCURSIONS AFTER USE OF INSULIN GLULISINE AND INSULIN ASPART IN PATIENTS WITH TYPE 2 DIABETES (2014) (0)
Sheehan's Syndrome with Subsequently Developped Diabetes Mellitus : Endocrinological Studies (1976) (0)
[Motilin and GIP--molecular cloning, chromosomal localization, and tissue specific expression of these genes]. (1989) (0)
Long-term glucose lowering effects of sitagliptin monotherapy and dietary contents in Japanese individuals with type 2 diabetes (2016) (0)
Effects of TXA2 and TXA2 receptor antagonist (ONO-NT-126) on rat colonic mucosal microcirculation and model of inflammatory bowel disease observation with electronic endoscope (1995) (0)
EFFECT OF TRUNCAL VAGOTOMY ON MOTILIN RELEASE INDUCED BY INTRADUODENAL INFUSION OF GLUCOSE OR FAT IN DOG (1982) (0)
[Oxidative stress and development of type 1 diabetes]. (2002) (0)
[Review: regulation of glucose metabolism]. (2002) (0)
Abstract: P962 PITAVASTATIN IMPROVES LIPID PROFILES AND REDUCES INFLAMMATION - KISHIMEN MULTI-CENTER PROSPECTIVE STUDY (2009) (0)
7085 Preventive clipping following bipolar snare removal of pedunculated colonic polyps. (2000) (0)
Issue Information (2016) (0)
A New Type of Familial Hyperproinsulinemia. Proinsulin Kyoto.:Proinsulin Kyoto (1992) (0)
[Pancreatic polypeptide (PP)]. (1995) (0)
[The history of incretin hormones]. (2011) (0)
Mechanism of Insulin Secretion Induced by Nutrient Abnormalities in Diabetes Mellitus. (2000) (0)
The Delayed Effect of Prolonged Physical Exercise on Plasma lipids, Apolipoproteins and LCAT activity (1987) (0)
Issue Information (2016) (0)
Soluble vascular cell adhesion molecule-1 is independently associated with soluble tumor necrosis factor receptor 2 in Japanese type 2 diabetic patients. (2007) (0)
A Study of Osteopenia in STZ-induced Diabetic Rats (1988) (0)
[Acromegaly and glucose metabolism]. (1977) (0)
Issue Information (2016) (0)
Clinical implication of diabetes education program declaring a goal in life for patients with diabetes mellitus (2016) (0)
Comparative effects of mono-, di- and trisaccharide on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. (1981) (0)
[Gastrointestinal hormones and their classification]. (1982) (0)
Issue Information (2016) (0)
[Motilin--structure and tissue specific expression of the human motilin gene and motilin receptor]. (1990) (0)
Effect of dietary environment on the development of impaired glucose tolerance and pancreatic hormone secretion in neonatal streptozocin-treated (NSZ) rats (1990) (0)
PO433 EFFICACY AND SAFETY OF LUSEOGLIFLOZIN IN YOUNGER AND ELDERLY JAPANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS: ANALYSIS OF POOLED DATA FROM LONG-TERM PHASE 3 TRIALS (2014) (0)
Analysis of Patterns of Heat Murmur in Relation to Types of Supracristal Ventricular Septal Defect (1991) (0)
[Pathogenesis of impaired insulin secretion in NIDDM]. (1999) (0)
Improved Control with Once-Daily Administration of Glimepiride for OHA Naive and Oral Monotherapy Japanese Patients without Clinically Significant Weight Gain (2004) (0)
P-169 The activity of the Japan Association for Diabetes Education and Care (2008) (0)
Glucose‐dependent insulinotropic polypeptide counteracts diet‐induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin‐responsive and proopiomelanocortin neurons in the arcuate nucleus (2023) (0)
Adrenomedullin on digestive tract (2000) (0)
Issue Information (2019) (0)
[Relationship between biologic and immunologic activities of peptide hormones (author's transl)]. (1975) (0)
The pathophysiology and etiology of diabetic osteopenia. (1991) (0)
3P-0706 The long-term effects of PPARγ agonist in subjects with type 2 diabetes (2003) (0)
Comparison of short-and long-acting glucagon-like peptide 1 receptor agonists on postprandial glucose excursion, insulin and glucagon secretions and gastric emptying (2016) (0)
Failure of Orally Administered Glucose to Suppress plasma Glucagon in Diabetic Patients Treated with Either Insulin or Sulfonylurea (1978) (0)
Effect of a high-protein diet on insulin and glucagon secretion in ventromedial hypothalamic (VMH) lesioned rats. (1985) (0)
A Study of Osteopenia in Children on Anticonvulsant Therapy (1988) (0)
[Changes in plasma motilin and gastric motility in the dog]. (1977) (0)
A randomized, placebo‐controlled trial to assess the efficacy and safety of sitagliptin in Japanese patients with type 2 diabetes and inadequate glycaemic control on ipragliflozin (2021) (0)
PO347 RISK FACTORS RESPONSIBLE FOR HYPOGLYCEMIA IN PATIENTS WITH DIABETES: A CROSS-SECTIONAL, SINGLE-CENTERED QUESTIONNAIRE-BASED STUDY (2014) (0)
Preface (2010) (0)
Issue Information (2017) (0)
The effects of curcumin on ion transport and muscle contraction in rat distal colon (1998) (0)
The effects of ginseng radix on glucose transport and muscle contraction in rat duodenum (1998) (0)
[Glucagon-like peptide-1 receptor agonists]. (2012) (0)
P-5 A novel gastric inhibitory polypeptide (GIP) receptor splice variant influences GIP sensitivity of pancreatic β -cells in obesity (2008) (0)
5 – Prohormone of Human Motilin (1990) (0)
Effects of SGLT2 inhibitor luseogliflozin under different dietary formula in type 2 diabetes: A randomized, controlled exploratory trial (2016) (0)
PYROLUS PRESERVING GASTRECTOMY AND ITS FUNCTIONAL PROGNOSIS (1980) (0)
The effect of mazindol on insulin and glucagon secretion in rats with ventromedial hypothalamic obesity (1988) (0)
[Experimental studies of secretin determination with a radioimmunoassay kit]. (1977) (0)
[Gastrointestinal hormones in diabetes mellitus]. (1990) (0)
1658-P: A Novel Mutation in Hepatocyte Nuclear Factor-1 Beta (HNF1B) in Maturity-Onset Diabetes of the Young 5 (MODY5) (2020) (0)
Role of Vitamin D in the Regulation of the Endocrine Pancreas (1984) (0)
Erratum to “A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement” [Diabetes Res. Clin. Pract. 73 (2006) 235–240] (2007) (0)
1018-P: Comparison of Short- and Long-Acting Glucagon-Like Peptide-1 Receptor Agonist Effects on Postprandial Glucose and Lipid Excursion via Gastric Emptying (2019) (0)
Issue Information (2017) (0)
The dual effect of alloxan modulated by 3-O-methylglucose or somatostatin on insulin secretion in the isolated perfused rat pancreas. (1980) (0)
PO400 JAPANESE PHYSICIANS' CHALLENGES WHEN DISCUSSING THE TYPE 2 DIABETES DIAGNOSIS WITH PATIENTS: INSIGHTS FROM A CROSS-NATIONAL STUDY (INTRODIA™) (2014) (0)
[Diabetes mellitus and its complications in Japan. The pathophysiology and etiology of diabetic osteopenia]. (1991) (0)
The relationship between food composition and factors responsible for diabetes (2005) (0)
Issue Information (2017) (0)
[The other gastrointestinal hormones in diabetes mellitus]. (2002) (0)
OP39 ROLE OF THE KATP CHANNEL IN GLUCOSE-INDUCED GIP SECRETION (2014) (0)
Sugar transport carrier.Abnormality in pathosis and significance. (1993) (0)
P-170 Evaluation of the questionnaire of members of the Japan Association for Diabetes Education and Care (2008) (0)
[Diet therapy for impaired glucose tolerance]. (2005) (0)
1P-0114 The relationship of intima-media thickness of carotid artery to multiple risk factors in Japanese subjects with type 2 diabetes (2003) (0)
Issue Information (2018) (0)
[Plasma 1.25 (OH)2D and PTH levels and urinary cyclic AMP response to exogenous PTH in PHP during childhood (author's transl)]. (1979) (0)
Issue Information (2015) (0)
Suppressive Effects of Polygonati Rh Output , GLUT 2 mRNA Expression Rat Liver izoma on Hepatic Glucose and Its Protein Content in (2006) (0)
Successful treatment of a Japanese type 1 diabetic patient by islet transplantation from non-heart-beating donors (2004) (0)
Issue Information (2016) (0)
Alogliptin for the treatment of Type 2 diabetes (2014) (0)
[Effect of ventromedial hypothalamic lesion on pancreatic hormone secretion: a longitudinal study]. (1982) (0)
Adrenomedullin inhibits gastric acid secretion and motility in rat (1998) (0)
Issue Information (2019) (0)
[History and perspective of classification for diabetes mellitus]. (2002) (0)
[Reversibility of diabetes mellitus]. (1982) (0)
Remnant-like particle cholesterol and insulin resistance in nonobese nonhypertensive Japanese glucose-tolerant relatives of type 2 diabetic patients. (2001) (0)
Title Incretin concept revised : The origin of the insulinotropicfunction of glucagon-like peptide-1the gut , the islets or both ? (2019) (0)
[Current status and future prospect of therapeutic agents for osteoporosis]. (2003) (0)
Effect of motilin on small intestinal internal pressure in anesthetized dogs (1993) (0)
P-60 Pitavastatin improves lipid profiles and reduces high-sensitivity CRP in Japanese diabetic subjects with hypercholesterolemia (KISHIMEN multi-center prospective study)-subanalysis of diabetic subjects (2008) (0)
Glucose Tolerance and Insulin and Gastric Inhibitory Polypeptide Responses following Intraduodenal Glucose Loading in Dogs with Obstructive Jaundice (1987) (0)
[Activation and regulation of vitamin D in pregnancy, fetus and newborn infant, with special reference to the etiology of rickets]. (1983) (0)
PO425 EFFICACY AND SAFETY OF LUSEOGLIFLOZIN IN JAPANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS BASED ON BMI: ANALYSIS OF POOLED DATA FROM LONG-TERM PHASE 3 TRIALS (2014) (0)
Abstracts of Selected Papers Presented at the 77th General Meeting of the Japanese Society of Gastroenterology (1992) (0)
[Ellsworth-Howard test by using 1-34h PTH as parathyroid hormone during childhood]. (1982) (0)
7084 Endoscopic aspiration mucosectomy using a bipolar snare for gastric neoplasms. (2000) (0)
Modulation by glucose and D-glyceraldehyde of glucagon and insulin secretion in the isolated perfused streptozotocin-treated rat pancreas (2007) (0)
[Insulin secretion and insulin sensitivity in subjects with impaired fasting glucose]. (2005) (0)
[Retrospective thoughts on endocrine and metabolism studies in the 20th century, and the prospects for the 21st century(discussion)]. (2002) (0)
Issue Information (2017) (0)
Issue Information (2017) (0)
[Present condition and future prospects in diagnosis of and therapy for diabetes mellitus]. (2009) (0)
[Glucose transporter--a novel gene family]. (1989) (0)
A novel ultrasonography measurement of internal carotid artery stenosis: comparison with the North American Symptomatic Carotid Endarterectomy Trial angiographic method (2018) (0)
[Plasma pancreatic polypeptide assay and the clinical significance]. (1990) (0)
The effect of guanabenz on an experimental colitis in rat (2000) (0)
The Asian Association for the Study of Diabetes: The first 10 years and the next 10 years (2020) (0)
Issue information (2019) (0)
Cyclic GMP binding protein of rat heart and urinary cyclic nucleotides in patients with diabetes mellitus before and after treatment. (1978) (0)
Issue Information (2017) (0)
Importance of Glucose-Dependent Insulinotropic Polypeptide vs lucagon-Like Peptide 1 Receptor Signaling for Beta Cell Survival in Mice (0)
EFFECTS OF VAGOTOMY ON THE ENDOCRINE PANCREAS DURING INTRAVENOUS GLUCOSE LOADS (1981) (0)
[Glucose transporters]. (1990) (0)
[Gastrointestinal hormones in diabetes mellitus]. (2002) (0)
[Review: regulatory factors of glucose metabolism]. (1997) (0)
[Pancreatic polypeptide]. (2005) (0)
MS41 PITAVASTATIN REDUCES HIGH-SENSITIVITY C-REACTIVE PROTEIN AND IMPROVES LIPID PROFILES IRRESPECTIVELY OF BODY MASS INDICES – SUBANALYSIS OF KISHIMEN MULTI-CENTER PROSPECTIVE STUDY (2010) (0)
P-139 The role of family nutritional support in Japanese patients with Type 2 diabetes (2008) (0)
771-P: Protein Intake at Breakfast Contributes to Maintenance of Skeletal Muscle Mass in Japanese Elderly Patients with Type 2 Diabetes (2019) (0)
PO419 ADDITION OF LIRAGLUTIDE TO OAD MONOTHERAPY IN JAPANESE SUBJECTS WITH TYPE 2 DIABETES: THE LIRA-ADD2OAD JAPAN TRIAL (2014) (0)

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