Zeger Debyser

Q: What Schools Are Affiliated With Zeger Debyser

Zeger Debyser is affiliated with the following schools: University of Iceland, KU Leuven

Zeger Debyser's AcademicInfluence.com Rankings

Zeger Debyser

Biology

#11595

World Rank

#14999

Historical Rank

Virology

#280

World Rank

#287

Historical Rank

biology Degrees

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Biology

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Zeger Debyser's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells* (2003) (706)
LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells* (2003) (502)
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. (2010) (441)
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. (2007) (304)
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100 (1994) (298)
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. (2010) (270)
Transportin-SR2 Imports HIV into the Nucleus (2008) (258)
Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication* (2005) (252)
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. (1992) (232)
Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus (2006) (227)
The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding* (2005) (206)
Cellular co-factors of HIV-1 integration. (2006) (201)
Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication (2006) (179)
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance (2011) (175)
Upscaling of lentiviral vector production by tangential flow filtration (2005) (164)
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. (1993) (162)
Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization (2012) (158)
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. (2000) (157)
Comparison of lentiviral vector titration methods (2006) (155)
Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain (2003) (153)
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites. (2013) (151)
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. (2010) (151)
Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. (2009) (149)
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. (2005) (143)
Identification of the LEDGF/p75 binding site in HIV-1 integrase. (2007) (137)
Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction (2003) (136)
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. (2002) (135)
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. (2008) (135)
Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV (2007) (131)
Chicoric acid analogues as HIV-1 integrase inhibitors. (1999) (130)
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. (1991) (130)
Novel targets for HIV therapy. (2008) (128)
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions (2013) (128)
Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. (2003) (126)
LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs (2012) (125)
Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α‐Synuclein (2003) (118)
Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction. (2010) (118)
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). (1998) (116)
Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75* (2004) (113)
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. (2006) (112)
State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. (2009) (112)
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy. (2013) (111)
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. (2012) (110)
Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7 (1994) (110)
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. (2000) (109)
New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture (2002) (108)
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. (2008) (106)
HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. (2005) (102)
Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75 (2009) (102)
Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function. (2011) (101)
Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ* (2009) (100)
DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration (2000) (99)
Inhibition of FK506 Binding Proteins Reduces α-Synuclein Aggregation and Parkinson's Disease-Like Pathology (2010) (96)
Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation (2011) (94)
Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis (2007) (94)
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75. (2007) (90)
Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations (2003) (85)
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents. (1992) (84)
Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. (2006) (81)
Block-And-Lock Strategies to Cure HIV Infection (2020) (80)
Host factors for retroviral integration site selection. (2015) (80)
LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV (2016) (80)
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360 (2004) (79)
Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1. (1997) (79)
The remarkable conformational plasticity of alpha-synuclein: blessing or curse? (2013) (78)
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. (2008) (78)
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors (2015) (78)
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors (2011) (76)
Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9 (2011) (74)
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region (2009) (74)
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. (1999) (74)
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints (2009) (69)
Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates (2016) (68)
Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. (2006) (67)
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease (2015) (67)
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents. (2008) (67)
Single-Cell Imaging of HIV-1 Provirus (SCIP) (2013) (66)
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. (2010) (65)
High‐level expression of active HIV‐1 integrase from a synthetic gene in human cells (2000) (65)
Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain. (1998) (64)
Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors (2011) (64)
Galectin-1 in melanoma biology and related neo-angiogenesis processes. (2012) (64)
Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging (2008) (63)
Fetal surgery is a clinical reality. (2010) (63)
Formation of a DNA Loop at the Replication Fork Generated by Bacteriophage T7 Replication Proteins* (1998) (63)
The aggregation of alpha‐synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy (2006) (61)
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering (2010) (61)
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs (1994) (59)
Inhibitory profile of a LEDGF/p75 peptide against HIV‐1 integrase: Insight into integrase–DNA complex formation and catalysis (2008) (59)
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014) (2014) (59)
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells (2012) (58)
Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain (2012) (56)
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. (2013) (56)
Interplay between HIV Entry and Transportin-SR2 Dependency (2011) (56)
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. (2011) (55)
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. (2009) (55)
Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer. (2012) (55)
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. (2011) (55)
Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)* (2012) (54)
PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide. (2015) (53)
Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing (2019) (53)
Novel inhibitors of HIV-1 integration. (2004) (51)
Lentiviral nuclear import: a complex interplay between virus and host (2007) (51)
Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. (2012) (50)
Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137 (2008) (50)
Establishment of latent HIV-1 reservoirs: what do we really know? (2019) (50)
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif (2015) (49)
Characterization of HIV-1 strains isolated from patients treated with TIBO R82913. (1994) (49)
Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex (2015) (49)
Retroviral integration: Site matters (2015) (48)
Activity of recombinant HIV-1 integrase on mini-HIV DNA. (1999) (48)
Assays for the evaluation of HIV-1 integrase inhibitors. (2001) (48)
Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives (2002) (46)
Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75) (2013) (46)
rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice. (2016) (44)
Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors. (2013) (44)
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. (2007) (42)
Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75 (2008) (42)
BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements (2014) (41)
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus (1997) (41)
Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex (2015) (41)
The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity (2012) (41)
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. (1992) (41)
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. (2009) (40)
A PET Brain Reporter Gene System Based on Type 2 Cannabinoid Receptors (2011) (40)
Comparative evaluation of three ELISA techniques and an indirect immunofluorescence assay for the serological diagnosis of Epstein-Barr virus infection. (1997) (40)
env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors (2002) (40)
HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort. (2014) (40)
Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors (2004) (39)
Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors (2012) (38)
Measuring protein‐protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75 (2005) (38)
In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma (2008) (38)
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. (2013) (38)
DNA-induced Polymerization of HIV-1 Integrase Analyzed with Fluorescence Fluctuation Spectroscopy* (2002) (37)
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity. (2012) (37)
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction. (2013) (36)
Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation (2015) (35)
Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography. (2008) (35)
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation. (2011) (34)
Immunohistochemical detection of transgene expression in the brain using small epitope tags (2010) (33)
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. (2003) (33)
Optimization of Multimodal Imaging of Mesenchymal Stem Cells Using the Human Sodium Iodide Symporter for PET and Cerenkov Luminescence Imaging (2014) (33)
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha‐synuclein and its clinical mutants A30P or A53T (2008) (33)
An integrated multi-electrode-optrode array for in vitro optogenetics (2016) (32)
The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication. (2006) (32)
Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2. (2010) (32)
Simple criterion for selection of flavonoid compounds with anti-HIV activity. (2007) (31)
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. (2008) (31)
HIV-1 integration as a target for antiretroviral therapy: a review. (2001) (31)
In Search of Authentic Inhibitors of HIV-1 Integration (2002) (31)
In search of small molecules blocking interactions between HIV proteins and intracellular cofactors. (2009) (31)
Non-invasive imaging of neuropathology in a rat model of α-synuclein overexpression (2007) (30)
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. (2018) (30)
Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery (2012) (30)
Regulator of G‐protein signaling 18 controls megakaryopoiesis and the cilia‐mediated vertebrate mechanosensory system (2012) (30)
The chromatin landscape at the HIV-1 provirus integration site determines viral expression (2020) (30)
Discovery of small molecule HIV-1 integrase dimerization inhibitors. (2012) (30)
Comparative Analysis of Different Peptidyl-Prolyl Isomerases Reveals FK506-binding Protein 12 as the Most Potent Enhancer of α-Synuclein Aggregation* (2011) (29)
Bioluminescence imaging of stroke-induced endogenous neural stem cell response (2014) (29)
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. (1992) (29)
Long‐term reversal of diabetes in non‐obese diabetic mice by liver‐directed gene therapy (2013) (29)
In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75. (2011) (28)
Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs (1993) (28)
Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. (2008) (27)
Biosafety of lentiviral vectors. (2003) (27)
New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogs as HIV‐1 Integrase Inhibitors (2007) (27)
Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein* (2012) (27)
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co‐activator LEDGF/p75 in prostate cancer cells (2012) (26)
Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides (2008) (26)
Synthesis and antiviral properties of some polyphenols related to Salvia genus. (2008) (26)
Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration (2011) (26)
Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1 (2007) (26)
Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity. (2008) (26)
Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry (2016) (25)
Noninvasive Bioluminescence Imaging of α-Synuclein Oligomerization in Mouse Brain Using Split Firefly Luciferase Reporters (2014) (25)
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase. (1992) (25)
Novel Virtual Screening Protocol Based on the Combined Use of Molecular Modeling and Electron-Ion Interaction Potential Techniques To Design HIV-1 Integrase Inhibitors (2007) (24)
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression (2011) (24)
Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration (2020) (24)
The α Crystallin Domain of Small Heat Shock Protein b8 (Hspb8) Acts as Survival and Differentiation Factor in Adult Hippocampal Neurogenesis (2013) (24)
The HIV-1 Integrase Mutant R263A/K264A Is 2-fold Defective for TRN-SR2 Binding and Viral Nuclear Import* (2014) (24)
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach (2019) (24)
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. (2007) (24)
2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. (2013) (24)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation (2018) (23)
Gene therapeutic strategies for neurodegenerative diseases. (2000) (23)
Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo. (2014) (23)
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process. (2011) (22)
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. (2014) (22)
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. (2007) (22)
Rilpivirine: a step forward in tailored HIV treatment (2011) (21)
Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds. (1992) (21)
Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection (2018) (21)
Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors (2008) (20)
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions. (2013) (20)
The fetal patient – ethical aspects of fetal therapy (2011) (20)
Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. (2012) (19)
Diffusion of Myelin Oligodendrocyte Glycoprotein in Living OLN-93 Cells Investigated by Raster-Scanning Image Correlation Spectroscopy (RICS) (2008) (19)
Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus. (1992) (19)
Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy. (2014) (19)
Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors. (1993) (19)
Impact of LEDGIN treatment during virus production on residual HIV-1 transcription (2019) (18)
A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. (1996) (18)
The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection (2019) (18)
Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors. (2005) (18)
Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents. (1995) (18)
Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action. (2007) (18)
HIV-1 IN/Pol recruits LEDGF/p75 into viral particles (2015) (18)
Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways. (2014) (17)
Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions (2016) (17)
Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy (2017) (16)
Resistance development of human immunodeficiency virus-1 against diketo derivatives (2003) (16)
Highly potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by the HIV-1-specific reverse transcriptase inhibitors (1992) (16)
Targeting Virus-host Interactions of HIV Replication. (2015) (16)
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. (2010) (16)
Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects (2020) (16)
Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras (2016) (16)
Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. (2007) (16)
Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets. (2017) (16)
A ubiquitous disordered protein interaction module orchestrates transcription elongation (2021) (15)
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors. (2018) (15)
Alteration of Cardiac Progenitor Cell Potency in GRMD Dogs (2012) (15)
Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase. (2014) (15)
A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication (2012) (14)
Elvitegravir: a once daily alternative to raltegravir. (2012) (14)
Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors (2013) (14)
New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays. (2013) (14)
Synthesis of New Potential HIV-1 Integrase Inhibitors (2004) (14)
Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD (2013) (13)
The free energy landscape of retroviral integration (2019) (13)
Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process. (2014) (13)
A short course on virology / vectorology / gene therapy. (2003) (13)
Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting* (2011) (13)
Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting. (2018) (13)
Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import (2018) (13)
Interaction of Transportin-SR2 with Ras-related Nuclear Protein (Ran) GTPase* (2013) (13)
Seeing genes at work in the living brain with non-invasive molecular imaging. (2009) (12)
Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF (2012) (12)
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75. (2015) (12)
De novo design of small molecule inhibitors targeting the LEDGF/p75-HIV integrase interaction (2012) (12)
2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4. (2016) (12)
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition. (2014) (12)
Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. (2005) (11)
Chemical crosslinking of the subunits of HIV‐1 reverse transcriptase (1996) (11)
A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors (2011) (11)
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. (2012) (11)
Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with μSPECT and quantitative MRI (2010) (11)
In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer. (2009) (11)
Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. (2007) (11)
Microwave‐Assisted Palladium‐Catalyzed Heterogeneous Vinylation of 2(1H)‐Pyridones (2009) (11)
Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging. (2009) (11)
Specific HIV-1 reverse transcriptase inhibitors. (1992) (11)
Identification of Authentic Inhibitors of HIV-1 Integration (2005) (10)
Bioluminescence imaging of therapy response does not correlate with FDG-PET response in a mouse model of Burkitt lymphoma. (2012) (10)
N-terminal half of transportin SR2 interacts with HIV integrase (2017) (10)
Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa. (1999) (10)
Y-box-binding protein 1 supports the early and late steps of HIV replication (2018) (10)
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent. (2010) (10)
Alpba-Oligodeoxynucleotides as Inhibitors of HIV Reverse Transcriptase (1989) (10)
Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection (2019) (10)
Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. (2014) (10)
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease (2016) (10)
Identification of small peptides inhibiting the integrase‐LEDGF/p75 interaction through targeting the cellular co‐factor (2013) (10)
Photoconversion of Far‐Red Organic Dyes: Implications for Multicolor Super‐Resolution Imaging (2018) (9)
On the cell biology of HIV integration from basic research to development of novel antiviral drugs. (2010) (9)
GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture (2021) (9)
Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector. (2016) (8)
Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia. (2016) (8)
HIV Virions as Nanoscopic Test Tubes for Probing Oligomerization of the Integrase Enzyme (2014) (8)
Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors (2014) (8)
Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (8)
Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration (2018) (8)
Quad's in it for antiretroviral therapy? (2012) (8)
Mutations in Both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology (2005) (8)
A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. (2007) (8)
A novel translational model for fetoscopic intratracheal delivery of nanoparticles in piglets (2016) (7)
Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection. (2013) (7)
Proceedings of the Frontiers of Retrovirology Conference 2016 (2016) (7)
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication. (1992) (7)
HIV-1 integrase inhibition: looking at cofactor interactions. (2015) (7)
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. (2008) (7)
Fueling HIV-1 integrase drug design with structural insights. (2012) (7)
Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection (2017) (7)
Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase (2006) (7)
Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors (2013) (6)
A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model. (2012) (6)
Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors (2016) (6)
Interaction of the HIV-1 intasome with Transportin 3 ( TNPO 3 or TRN-SR 2 ) (2012) (6)
Microwave-Assisted Silver(I)-Mediated Selective O-Alkylation of Aromatic Imidate Systems (2009) (6)
Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety (2020) (6)
The fetal respiratory system as target for antenatal therapy (2011) (6)
HIV-1 Integrase Drug Discovery Comes of Age (2013) (6)
Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry (2018) (6)
Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus (2021) (5)
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. (2007) (5)
Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy (2014) (5)
8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada (2015) (5)
Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells. (2005) (5)
LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy (2009) (5)
Role of Transportin-SR2 in HIV-1 Nuclear Import (2021) (5)
Cellular Cofactors of HIV Integration (2011) (5)
LEDGINs: first-in-class inhibitors of LEDGF/ p75-integrase interaction and HIV replication (2010) (5)
Structural Modification of Diketo Acid Portion in 1H-Benzylindole Derivatives HIV-1 Integrase Inhibitors (2009) (5)
Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies (2019) (5)
Pre-clinical evaluation of HIV replication inhibitors that target the HIV-integrase-LEDGF/p75 interaction (2011) (4)
Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites (2013) (4)
Imaging the Replication of Single Viruses: Lessons Learned from HIV and Future Challenges To Overcome. (2020) (4)
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. (2003) (4)
Non-invasive imaging reveals stable transgene expression in mouse airways after delivery of a non-integrating rAAV vector (2015) (4)
Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids (2022) (4)
New [4,5,1-JK][1,4]benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 and are synergistic with 2',3'-dideoxynucleoside analogs (1994) (4)
Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling (2019) (4)
RNAi-based treatment of HIV/AIDS: Current status and perspectives (2006) (4)
Analysis of ex vivo HIV-1 infection in a controller-discordant couple (2018) (4)
Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival (2021) (3)
Microwave‐Assisted Silver(I)‐Mediated Selective O‐Alkylation of Aromatic Imidate Systems. (2010) (3)
LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators (2021) (3)
Long term pulmonary gene therapy with a lentiviral vector in a fetal rat model (2006) (3)
LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection. (2021) (3)
Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF / p 75 (2008) (3)
Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity (2012) (3)
Virus evolution reveals LEDGF/p75 as the sole mediator of chromosomal tethering (2007) (3)
Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors. (2015) (3)
WS01.1 rAAV2/5 encoding a truncated CFTR rescues the CF phenotype in intestinal organoids and a CF mouse model (2015) (2)
Use of LEDGF/p75 fusion proteins to retarget lentiviral integration outside of genes (2010) (2)
Switching STRATEGIES in HIV treatment. (2014) (2)
Assays for evaluation of HIV-1 integrase enzymatic activity, DNA binding, and cofactor interaction (2011) (2)
rAAV-mediated gene transfer of a truncated CFTR rescues the cystic fibrosis phenotype in human intestinal organoids and CF mice (2015) (2)
Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site (2022) (2)
Expression of HIV‐1 integrase in CEM cells inhibits HIV‐1 replication (2004) (2)
LEDGF/p75 controls 3D-localization of HIV-1 provirus in the nuclear compartment of infected cells (2013) (2)
Towards a Cure: HIV Reservoirs and Strategies to control them (2010) (2)
DNA substrates for studying replication mechanisms: synthetic replication forks. (1995) (2)
1H)-One and-Thione Derivatives ArePotent Inhibitors ofHuman Immunodeficiency Virus Type1Replication andAre Synergistic with2',3'-Dideoxynucleoside Analogs (1994) (2)
Expansion microscopy allows high resolution single cell analysis of epigenetic readers (2022) (2)
Chimeric virus technology (CVT) for HIV env-genes to evaluate the resistance/susceptibility profile towards HIV entry inhibitors (2002) (2)
Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene (2002) (2)
New antiviral target on HIV-1 reverse transcriptase revealed by TIBO derivatives (1991) (2)
Erratum: Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetraacetyl esters (Molecular Pharmacology (2000) 58 (641-648)) (2001) (2)
Imaging of lentiviral vector-mediated gene transfer to mouse muscle with micro positron emission tomography (PET) and bioluminescence imaging (BLI) (2006) (2)
LEDGINs reveal a role for LEDGF/p75 in late stage HIV replication (2013) (2)
Construction of a synthetic gene for high level expression of active HIV-1 integrase in human cells (2000) (1)
Potent and highly selective HIV-1 specific inhibition by a new series of alfa- anilino-phenylacetamide (alfa-APA) derivatives targeted at HIV-1 RT (1992) (1)
LEDGINs, a novel class of antivirals targeting HIV integrase during integration and assembly (2013) (1)
Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives (2009) (1)
Quantification of 3D T2*-weighted MR images allows evaluation of different viral vectors for stable MR reporter gene expression in the rodent brain (2010) (1)
Hope for non-responders with hepatitis C virus and cirrhosis (2015) (1)
Resistance to Inhibitors of HIV‐1 Integrase (2011) (1)
Structural Modification of Diketo Acid Portion in 1H‐Benzylindole Derivatives HIV‐1 Integrase Inhibitors. (2009) (1)
Structure-function analysis of the interface between HIV-1 integrase and the cellular co-factor LEDGF/p75 (2007) (1)
Potent and selective inhibition of HIV-1 and HIV-2 replication by a novel class of bicyclams targeted at viral uncoating (1992) (1)
Targeting the HIV integration process in antiviral therapy. (2008) (1)
LEDGF/P75 as a Co-factor of HIV-1 Integrase and as a New Antiviral Target (2008) (1)
Immunological ignorance allows long-term gene expression following perinatal rAAV-mediated gene transfer to murine airways (2013) (1)
Interaction of TIBO and TIBO-like compounds with HIV-1 RT (1991) (1)
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells (2012) (1)
Comparison of RT gene sequences from HIV-1 strains with different sensitivity to TIBO derivatives (1992) (1)
Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. (2020) (1)
rAAV2/5 encoding truncated CFTR corrects CF phenotype in mouse nasal epithelium (2014) (1)
Is transportin-SR2 mediated nuclear import of HIV mediated by integrase or capsid? (2010) (1)
Dissecting the HIV integration site distribution pattern using a human LEDGF/p75 knockout cell line (2012) (1)
SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus (1997) (1)
Application of Waters Oasis column in the purification and metabolite analysis of radiotracers (2007) (1)
In vitro evaluation of a novel radiolabeled bi-cyclic nucleoside analog as PET reporter probe for Varicella zoster virus thymidine kinase gene expression (2007) (1)
Regional lentiviral vector-mediated overexpression of alpha-synuclein in adult rodent brain (2001) (1)
Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors (2011) (1)
Real-time characterization of the interaction of HIV-1-specific inhibitors with their binding site at the HIV-1 reverse transcriptase (RT) using surface plasmon resonance and biosensor technology (1993) (1)
Molecular Mechanism of LEDGF/p75 Dimerization. (2020) (1)
4 Viral entry as the primary target of anti-HIV activity of chicoric acid and its tetra-acetyl esters (2000) (1)
Synthesis of New Potential HIV-1 Integrase Inhibitors. (2005) (1)
Article Transportin-SR2 Imports HIV into the Nucleus (2008) (1)
2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance (2013) (1)
Novel targets for HIV therapy: small molecules blocking IN-LEDGF/p75 interaction (2009) (1)
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions (2013) (1)
Validation of PET radioligands for visualisation of the cannabinoid type 2 receptor in a rat model with local cerebral CB2R expression (2009) (1)
Influence of initial conditions on the development of resistance to TIBO derivatives in cell culture (1992) (1)
CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import (2021) (1)
Quantitative assessment of gene-based versus particle based MRI contrast agents for progenitor cell tracking in rodent brain (2010) (1)
Microwave‐Assisted Synthesis of Fluoroquinolones and Their Nucleosides as Inhibitors of HIV Integrase. (2007) (1)
New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogues as HIV‐1 Integrase Inhibitors. (2007) (1)
LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication (2010) (1)
Supporting Information for : Structure , mechanics , and binding mode heterogeneity of LEDGF / p 75-DNA nucleoprotein complexes revealed by scanning force microscopy (2014) (1)
Quantitative comparison of 123I-FP-CIT microSPECT dopamine transporter binding and histology in a rodent model for Parkinson's disease by lentiviral vector-mediated overexpression of alpha-synuclein (2004) (1)
Novel and scalable approach to research grade AAV vector manufacturing and separation of distinct AAV serotypes (2009) (1)
The aggregation of alpha‐synuclein is stimulated by FK506 Binding Proteins as shown by Fluorescence Correlation Spectroscopy (2006) (1)
Mutations in Human Immunodeﬁciency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137 (cid:1) (2008) (1)
Allosteric properties of heterodimeric HIV-1 reverse transcriptase (1991) (1)
BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis (2022) (1)
HIV-1 Integrase strand transfer inhibitors (INSTIs): design, synthesis and biological evaluation (2007) (1)
The LEDGINs: Rational design of first in class LEDGF/p75-integrase inhibitors with potent antiviral activity (2010) (1)
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the phase I/II clinical trial drug S-1360 (2004) (1)
LEDGF/p75 controls 3D-localization of HIV-1 provirus in the nuclear compartment of infected cells (2013) (1)
Establishment of a human cell line that constitutively expresses high levels of HIV-1 integrase (1999) (1)
env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors (2003) (1)
Track A Basic Science (2012) (1)
Comparative study of different rAAV serotypes for transduction of dopaminergic neurons in rodent brain (2009) (0)
Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs (2020) (0)
An engineered tethering factor to redirect lentiviral vector integration (2008) (0)
Evaluation of small epitope tags for immunohistochemical detection of transgene expression in vivo (2008) (0)
Lentiviral integration and the role of the cellular cofactors LEDGF/p75 and transportin-SR2 (2010) (0)
Selected talk 2 MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation (2015) (0)
Allosteric inhibition of endogenous HIV-1 reverse transcription by TIBO derivatives (1992) (0)
Optimization of MULTIMODAL mesenchymal stem cell imaging using the human sodium iodide symporter for PET and Cerenkov luminescence imaging (2014) (0)
The HIV-1 cPPT/CTS fragment mediates efficient transgene expression from lentiviral vectors (2002) (0)
Live bioluminescence imaging of endogenous neuronal stem cell esponse in a mouse model of stroke (2012) (0)
Discovery of HIV-1 IN - LEDGF/p75 interaction inhibitors using a virutal screening approach (2009) (0)
HIV-1 integrase variants retarget proviral integration and are associated with disease progression (2015) (0)
LEDGF/p75 switches from a dynamic to a tight chromatin interaction (2009) (0)
Quantitative bioluminescence imaging of the migration of endogenous neural stem cells in mouse brain (2007) (0)
Presence of a putative s/mar in the encoding region of HIV-1 (2006) (0)
Distinct antiviral resistance profiles for three authentic HIV integrase inhibitors L-708,906, S-1360 and V-165 (2002) (0)
Optimization of a potent hiv-1 integrase strand transfer inhibitor (insti): molecular modeling, synthesis and anti-hiv activity (2009) (0)
Terzic A and Nelson TJ Regenerative Medicine editorial to Dubois C and Arminan A JACC 2010 (2013) (0)
Characterization of the LEDGF/p75 binding site in HIV-1 integrase (2007) (0)
WS1.4 A rAAV2/5 based gene therapy model for cystic fibrosis airway disease (2014) (0)
Quantitative evaluation of reporter gene and particle- based labeling methods for MR imaging of endogenous neural stem cell progeny migration in the rodent brain (2012) (0)
T-cell directed gene therapy approach for HIV/AIDS based on LEDGF/p75 (2011) (0)
Transient expression of LEDGF/p75 chimera by RNA electroporation retargets lentiviral integration away from genes (2011) (0)
Lentiviral vectors mediate persistent knock-down of gene expression by RNA interference in mouse brain (2003) (0)
PFV intasome with inhibitor MB-76 (2013) (0)
The role of LEDGF/p75 chromatin binding domains in HIV integration site targeting (2010) (0)
Validation of the MLL-LEDGF/P75 interaction as a therapeutic target for mixed lineage leukemia (2016) (0)
Integrase mediates efficient expression of HIV-1 vectors after integration (2003) (0)
Analysis of the interaction between the HIV-1 tethering factor LEDGF/p75 and its cellular interaction partner POGZ (2008) (0)
Long term follow up of fetal airway gene transfer with AAV5 in the mouse model (2011) (0)
Lentiviral vectors as a powerful tool to generate transgenic rodent animal models (2008) (0)
A coexpression system for the heterodimeric reverse transcriptase of the human immunodeficiency virus type 1 in the study of the functionality of p51, the small subunit of HIV-1 RT (1995) (0)
Lens epithelium-derived growth factor/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis (2017) (0)
Validation of a triple reporter lentiviral vector encoding eGFP, firefly luciferase and HSV-thymidine kinase in vitro and in vivo (2008) (0)
Regulator of G protein signaling 18 regulates megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system (2011) (0)
Figure S4: Analysis of knockdown efficiency in HIV-1-infected U2OS-C5 cells from Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (0)
Development of an alphascreen®-based HIV-1 integrase dimerization assay leading to the discovery of novel small molecule inhibitors (2011) (0)
IN variants retarget HIV-1 integration and are associated with disease progression (2015) (0)
The Free Energy Landscape of Retroviral Integration and Molecular Mechanisms of DNA Compaction (2020) (0)
Non-invasive long term follow-up of pulmonary gene transfer with a lentiviral vector in a fetal rat model (2007) (0)
Effect of parkin overexpression in a mouse model for Parkinson’s disease (2004) (0)
Impact of polymorphisms at HIV-1 integrase positions 119 on viro-immunological parameters in HIV-1 infected naïve patients (2015) (0)
LEDGF/p75 is the sole mediator of chromosomal tethering during HIV integration (2006) (0)
The viral load of a divergent clinical HIV-1 strain can only be quantified by the branched DNA assay (1997) (0)
Efficient co-expression of multiple imaging reporters in rodent brain using multicistronic lentivectors (2008) (0)
Binding of fluorescent oligonucleotides to HIV-1 integrase using fluorescence fluctuation analysis: oligonucleotides induce oligomerization (2001) (0)
Protein-Chromatin interactions of LEDGF/p75 as a novel target for drug discovery (2016) (0)
Study of the role of PINK1 in mitochondrial function and morphology (2007) (0)
Functional imaging of individual cells in deep brain regions of free-moving mice (2013) (0)
Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions (2020) (0)
A human LEDGF/p75 knockout cell line to study the mechanism of HIV-1 integration site distribution (2011) (0)
Cellular cofactors as drug targets (2015) (0)
Optimization of miRNA-based knockdown lentiviral vectors (2011) (0)
The integrase of the human immunodeficiency virus as a novel target for the antiviral therapy of AIDS. (2003) (0)
Scientific program (1992) (0)
Optogenetic modification of the conventional induction paradigm of NMDA receptor dependent long-term potentiation (2016) (0)
A study of the diffusion of HIV-1 integrase, EGFP and DNA inside HeLa cells with fluorescence correlation microscopy (2001) (0)
CCDC 600092: Experimental Crystal Structure Determination (2006) (0)
rAAV 2/7 –mediated overexpression of wild type and A53T mutant α-synuclein in rat brain induces rapid dopaminergic dysfunction (2010) (0)
Novel mutations in HIV-1 integrase associated with resistance to diketo acids (2001) (0)
Rapid emergence of HIV-1 resistance to R82913 in only a minority of treated patients (1993) (0)
Visualization of HIV-1 DNA in infected cells using a new fluorescent virus-based reporter system (2011) (0)
Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) (2015) (0)
Cellular tunable focus FCS for studying the molecular mechanism of LEDGF/p75 mediated chromatin tethering of HIV-1 integrase (2009) (0)
Bromodomain and extra-terminal (BET) proteins target MLV-based vector integration to transcription start sites (2013) (0)
HIV-1 specific inhibition of reverse transcriptase by TIBO-derivatives: a new mechanism of antiviral action discovered by drug screening (1990) (0)
Liver-directed gene therapy results in the permanent reversal of autoimmune diabetes in non obese diabetic mice (2009) (0)
The role of PINK1 in mitochondrial function and morphology (2008) (0)
FK506 Binding Protein 12: The Main Peptidyl-prolyl isomerase influencing alpha-synuclein aggregation in a cellular model for Parkinson’s disease (2010) (0)
Investigation of the role of neuroinflammation in alpha-synuclein-linked dopaminergic neurodegeneration in rat brain (2013) (0)
Diffusion of eGFP labeled protein in oligodendroglial cells (2007) (0)
Parkin protects against neurotoxicity in rodent models for Parkinson’s disease (2006) (0)
Correction: Y-box-binding protein 1 supports the early and late steps of HIV replication (2020) (0)
Highly efficient in vitro integration by the integrase of the human immunodeficiency virus type 1 using a novel DNA substrate (1997) (0)
Oral abstracts of the HIV Cure and Reservoir Symposium 2017 (2017) (0)
Combined non-invasive bioluminescence and magnetic resonance imaging of pulmonary gene expression after adeno-associated viral vector administration (2009) (0)
Detargeted integration of MLV-based vectors by integrase mutants that disrupt BET protein interaction (2014) (0)
HIV-1 specific phenylacetamide derivatives: a novel class of reverse transcriptase inhibitors with potent and selective antiviral activity in vitro (1992) (0)
LEDGINs, a novel class of antivirals targeting HIV integrase during integration and assembly (2013) (0)
Nuclear imaging of mesenchymal stem cells using the human sodium iodide symporter (2013) (0)
Validation of FKBP12 as modulator of α-synuclein aggregation and neurotoxicity (2011) (0)
Specific labeling and noninvasive imaging of adult endogenous neural stem cells using conditional viral vectors (2010) (0)
LEDGF/p75 fusion proteins to retarget lentiviral integration away from genes (2010) (0)
Disulfide-containing macrolides that inhibit a late stage of the replicative cycle of human immunodeficiency virus (1997) (0)
Imaging of lentiviral gene transfer in mouse brain (2007) (0)
Amniotic fluid derived mesenchymal stem cells for perinatal cardiopulmonary therapy (2011) (0)
Viral vector technology for target validation and drug discovery (2006) (0)
In vivo optical imaging of individual cells in deep brain regions of mouse brain (2011) (0)
Abstract 2945: Methyl CpG binding protein MeCP2 interacts with the stress-response transcription coactivator LEDGF/p75 and modulates its survival and transcription functions (2010) (0)
Characterization of YB-1 as cellular co-factor of HIV replication (2015) (0)
Validation of new cellular cofactors of HIV integrase and mapping of interaction sites (2006) (0)
Conditional viral vectors for specific labeling and noninvasive imaging of neuronal cell populations in mouse brain (2009) (0)
BET-independent MLV-based vectors integrate efficiently and associate less with proto-oncogene transcription start sites (2014) (0)
Resistance of HIV-1 RT to TIBO derivatives induced by site-directed mutagenesis (1992) (0)
Long-term follow up of pre- and postnatal pulmonary gene transfer with rAAV2/5 in a mouse model (2011) (0)
653: Evaluation of different screening models for optimal pulmonary transduction with lentiviral vectors (2008) (0)
Protein-protein interactions during HIV-1 replication revealed by chemical cross-linking (1996) (0)
Kinetics of HIV integration as analyzed by quantitative PCR (2001) (0)
Conditional viral vectors for specific labeling and noninvasive imaging of endogenous neural stem cells in mouse brain (2010) (0)
Multimerizationand Modulate Integrase Binding Site of Integrase Block HIV Small-Molecule Inhibitors of the LEDGF/p75 (2012) (0)
Quantification of lentiviral vectors by a two-step real-time RT-PCR (2002) (0)
Fetal tracheal injection technique to target the fetal mouse lung (2009) (0)
Five-drug antiretroviral therapy for primary HIV infection? (2015) (0)
PERMANENT REVERSAL OF AUTOIMMUNE DIABETES IN NON OBESE DIABETIC MICE AFTER LENTIVIRAL HEPATIC INSULIN GENE THERAPY: 33 (2008) (0)
HIV-1 IN/Pol recruits LEDGF/p75 into viral particles (2015) (0)
The HIV-2 OGH Double Reporter Virus Shows that HIV-2 is Less Cytopathogenic and Less Sensitive to Reactivation from Latency than HIV-1 in Cell Culture (2023) (0)
IMMUNISATION OF AFRICAN PRETEEN / ADOLESCENT GIRLS AND YOUNG WOMEN WITH THE HPV-16 / 18 AS 04-ADJUVANTED VACCINE (2011) (0)
Neuron-specific targeting of lentiviral vectors using neuron-restrictive silencer elements (2002) (0)
The development and characterization of rAAV vectors in patient-derived intestinal organoids and CF mice as a treatment for cystic fibrosis (2016) (0)
The influence of genetic variation of transportin-SR2 (TNPO3) gene on susceptibility to HIV-1 infection and disease outcomes (2011) (0)
HIV integraseR263A/K264A is defective for TRN-SR2/IN interaction and nuclear import of the PIC (2014) (0)
Optimization of reporter-gene imaging in mesenchymal stem cells using the human sodium iodide symporter (2013) (0)
Bioluminescence imaging of endogenous stem cells in a mouse model of stroke (2011) (0)
Probing Protein-Protein Interactions in a Single Virus: Application to HIV Integrase Oligomerization (2014) (0)
Life-long gene expression in mouse airways after rAAV2/5 based gene therapy (2014) (0)
Expression pattern and cell specificity of recombinant AAV 2 pseudotyped vectors in the mouse visual cortex (2014) (0)
Importance of amino acids V165, T206, and N155 for the interaction of pyranodipyrimidines with HIV-1 Integrase as revealed by molecular docking and resistance selection (2005) (0)
HIV-1 Integrase Inhibitors: Pharmacophore Modeling and Rational Drug Design (2005) (0)
PF219 THE LEDGF/P75 HOMOLOG HRP2 IS NOT IMPORTANT FOR THE INITIATION OF MLL-REARRANGED LEUKEMIA (2019) (0)
Design and characterization of novel integration inhibitors (2011) (0)
OP02.01: Long term pulmonary gene therapy with a lentiviral vector in a fetal rat model (2007) (0)
584: Ex-vivo assessment of the effect of airway epithelial barrier disruption on transduction efficiency of a lentiviral vector in fetal rat tracheas (2007) (0)
Can endogenous stem cells in a mouse model of stroke be visualized using bioluminiescence imaging (2011) (0)
In vivo long-term cell marking of neural stem cells in adult rodent brain by lentiviral vectors (2004) (0)
WS11.3 The last 10%: small molecule screening for correctors of rare CFTR processing mutations (2020) (0)
TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its (2012) (0)
Overexpression of the LEDGF/p75 integrase binding domain abrogates HIV-1 replication in cells (2006) (0)
Figure S5: Effect of Interferon-α on PHF13 expression from Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (0)
rAAV2/5 mediated perinatal gene therapy for cystic fibrosis (2013) (0)
Construction of mesenchymal stem cells as vehicles for recombinant protein delivery (2011) (0)
Evaluation of lentiviral vector mediated gene transfer into the adult mouse brain (2000) (0)
The role of neuroinflammation in α-synuclein-linked dopaminergic neurodegeneration in rat brain (2015) (0)
LEDGIN mediated inhibition of the IN-LEDGF/p75 interaction reduces reactivation from latency (2015) (0)
Inhibition of the formation of HIV-1 DNA by TIBO compounds (1991) (0)
Model of the HIV-1 integrase-LEDGF/p75 complex as revealed by atomic force microscopy and fluorescence correlation spectroscopy (2006) (0)
Neuroprotective effect of parkin in a rodent model for Parkinson’s disease (2005) (0)
Quantitative comparison of different viral vector systems for stable MR reporter gene transfer to the rodent brain (2010) (0)
Quantitative bioluminescence imaging of the migration of lentiviral vector-labeled endogenous neural stem cells in mouse brain (2007) (0)
Non-invasive imaging of neuropathology in a rat model for Parkinson’s disease based on overexpression of alpha-synuclein (2005) (0)
Inhibition of Simian immunodeficiency virus (SIV) from African green monkeys by TIBO and HEPT derivatives (1992) (0)
Bioluminescence imaging in rodent brain (2009) (0)
Transduction pattern and cell specific expression of recombinant AAV 2 pseudotyped vectors in the mouse visual cortex (2013) (0)
Stable gene transfer in type B cells results in long-term marking of migrating and differentiating neuronal stem cells in the adult rodent brain (2005) (0)
Structural and functional characterization of the interaction of chromatin reader LEDGF/p75 with its cellular and viral binding partners (2016) (0)
Generation and characterization of transgenic PINK1 knock-down mice using lentiviral vectors (2009) (0)
Retargeting lentiviral integration away from genes (2009) (0)
Pink1 depletion affects mitochondrial homeostasis (2010) (0)
Evaluation of Different rAAV Serotypes and Their Tropism for the Lung Using Non-Invasive Imaging in a Fetal Mouse Model (2010) (0)
JPO2 and HIV-1 integrase both bind to the C-terminal part of LEDGF/p75 but through a different binding mechanism (2007) (0)
BET proteins mediate integration site selection of MLV much alike LEDGF/p75 in HIV integration (2014) (0)
In vivo assesment of neuronal function in mouse brain with confocal endomicroscopy (2012) (0)
Visualisation of the human immunodeficiency virus type 1 cDNA by click chemistry (2015) (0)
Comparative study of rAAV2/7 purification methods for transduction in the Mouse brain following serum free production (2008) (0)
Binding and Viral Nuclear R 263 A / K 264 A Is 2-fold Defective for The HIV-1 Integrase Mutant Microbiology : (2014) (0)
Structure based discovery of small molecule inhibitors targeting the protein-protein interaction of HIV-1 IN and LEDGF/p75 (2008) (0)
Figure S2: No effects of doxycycline treatment on HIV-1 infection in parental U2OS cells. from Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (0)
Non-invasive bioluminescence imaging of alpha-synuclein oligomerization in mouse brain (2012) (0)
Optimisation of lentiviral vector-technology for airway gene therapy (2007) (0)
MicroSPECT validation of a rodent model for Parkinson's disease by lentiviral vector-mediated overexpression of alpha-synuclein (2004) (0)
LEDGF/p75 is a novel cellular interactor of HIV-1 integrase, essential for its stability and nuclear accumulation in human cells (2003) (0)
Lentiviral vectors for cell marking of neural progenitor cells in adult rodent brain (2004) (0)
A quick method to generate knock-down cell-lines using lentiviral vectors (2005) (0)
Validation of a rat model for Parkinson’s disease based on lentiviral vector-mediated overexpression of alpha-synuclein (2004) (0)
Site-directed mutagenesis of HIV-1 reverse transcriptase (1991) (0)
Tenofovir prodrugs: similar but not the same. (2017) (0)
Bioluminescence imaging of alpha-synuclein oligomerization in cell culture and mouse brain using split firefly luciferase reporters (2014) (0)
The lung as target for perinatal gene therapy (2007) (0)
WS16.01 Correction of the drug-refractory CFTR mutation L227R by prime editing (2022) (0)
Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions (2020) (0)
The cellular co-factor LEDGF/p75 determines lentiviral integration sites in the chromosome (2008) (0)
Artificial IN-peptide fusions provide BET-independent MLV-vectors with a safer integration profile (2016) (0)
Non-invasive measurement of lentiviral vector-mediated locoregional gene transfer into adult mouse brain with bioluminescence imaging (2005) (0)
Characterization of the role of PINK1 in cell culture and in PINK1 knock-down transgenic mice (2009) (0)
Differential kinetics and susceptibilities of mutagenized HIV-1 reverse transcriptases (RT) to HIV-1-specific RT inhibitors (1992) (0)
Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import (2018) (0)
Proline isomerization affects protein folding and aggregation (2009) (0)
Transient knock-down of the Von Hippel Lindau binding protein 1 (VBP1) in HeLaP4 cells enhances HIV-1 replication (2008) (0)
Studies of the interactions of transportin-SR2 with HIV-1 integrase and RAN (2011) (0)
Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection (2019) (0)
Systematic evaluation of bicistronic lentiviral vector constructs for reporter gene imaging (2007) (0)
HIV-1 integrase is transported to the nucleus when expressed as a fusion protein with GFP (1999) (0)
Visualizing and quantifying HIV-host interactions with fluorescence microscopy (2011) (0)
Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles (2020) (0)
Small molecule inhibitors of HIV-1 integrase dimerization (2011) (0)
TIBO derivatives: a new class of potent and selective inhibitors of HIV-1 replication (1991) (0)
Biochemical analysis of HIV-1 integrase interactions with transportin-SR2 reveals functional protein-protein contacts (2011) (0)
FRET Reveals an Interplay of the HIV-1 Integrase Subunits during its Journey from the Cytoplasm into the Nucleus (2016) (0)
Retargeting of HIV integration via the LEDGF/p75 integrase binding domain fused to alternative DNA binding domains (2009) (0)
Unraveling the dynamic interplay of HIV-1 integrase during its journey from the cytoplasm into the nucleus using fluorescence microscopy (2015) (0)
Multicistronic Lentiviral Vectors for Efficient coexpression of multiple imaging reporters in rodent brain (2008) (0)
Potential chemotherapeutic targets in the replicative cycle of HIV (1994) (0)
Targeted editing of the PSIP1 gene encoding LEDGF/p75 as a functional cure strategy for HIV (2016) (0)
FK506-binding proteins stimulate the aggregation of alpha-synuclein (2007) (0)
Kinetics of the 3’ processing reaction of HIV-1 integrase as investigated with Fluorescence Cross Correlation Spectroscopy (2004) (0)
The central DNA flap is critically important for HIV replication (2006) (0)
Figure S3: No effects on HIV-1 LTRtransactivation when parental U2OS cells were treated with doxycycline post infection from Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (0)
The HIV-1 DNA flap stimulates both the efficiency and the kinetics of lentiviral vector transduction (2005) (0)
Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeﬁciency Virus Integrase Strand Transfer Inhibitors (cid:1) (2008) (0)
Redistribution of HIV-based viral vectors for safer gene therapy (2013) (0)
Type 2 cannabinoid receptor based reporter gene constructs for brain PET imaging (2009) (0)
Selected talk 2 A phosphoproteome analysis at the host-respiratory syncytial virus interphase (2014) (0)
P031 The last 10%: small molecule screening for correctors of rare CFTRprocessing mutations (2021) (0)
Author Correction: Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing (2020) (0)
LEDGINs hamper the establishment of a reactivation competent HIV reservoir in CD4+ T-cells (2016) (0)
From 3D-pharmacophore models to synthetic route towards anti-HIV agents (2009) (0)
Gene transfer of wild-type en mutant human alpha-synuclein into adult rodent brain by means of lentiviral vectors (2001) (0)
Integrase S119P mutation correlates with disease progression in HIV-1 naïve patients (2015) (0)
FK506 binding proteins stimulate alpha-synuclein aggregation in human neuroblastoma cells (2007) (0)
Selective inhibitory effect of a TIBO compound, R82150, on the activity of HIV-1 reverse transcriptase (1991) (0)
Novel Approach to Intermediate Scale AAV Vector Manufacturing and Separation of Distinct AAV Entities on Iodixanol Gradients (2009) (0)
In vitro evaluation of varicella-zoster virus (VZV) thymidine kinase as a PET reporter gene with radiolabeled bi-cyclic nucleoside analogs (2006) (0)
Investigation of the HIV-1 integrase interactor LEDGF/p75 with fluorescence cross-correlation spectroscopy (2006) (0)
Impact of central fragment of the HIV-1 genome on lentiviral vector performance (2001) (0)
Detection and quantification of the migration of lentiviral vector-labeled endogenous neural stem cells in mouse brain with bioluminescence imaging (2007) (0)
Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment. (2022) (0)
FK506 decreases dopaminergic neurodegeneration and neuroinflammation in an optimized α-synuclein rat model for Parkinson’s disease (2012) (0)
Rescue of HIV integration via LEDGF/p75 fused to alternative DNA binding domains (2008) (0)
Neuroprotective effect of parkin in the 6-OHDA rat lesion model for Parkinson’s disease (2005) (0)
Safer, more randomized lentiviral vector integration using artificial LEDGF chimeras (2015) (0)
Calcium imaging of individual cells in deep brain regions of live mice (2013) (0)
Comparative study of different recombinant viral vectors for transduction of dopaminergic neurons in rodent brain (2008) (0)
FUNCTIONAL ANALYSIS OF A NOVEL HALOALKANE DEHALOGENASE DsvA ISOLATED FROM THERMOPHILIC BACTERIUM SACCHAROMONOSPORA VIRIDIS DSM 43017 (2015) (0)
Transduction efficiency of HIV-1 derived lentiviral vectors in T-cell lines, primary macrophages and hematopoietic stem cells (2001) (0)
Gene transfer into adult mouse brain using lentiviral vectors (1999) (0)
Impact of LEDGIN treatment during virus production on residual HIV-1 transcription (2019) (0)
Development of a high-throughput screening assay for inhibitors of the integrase-transportin-SR2 interaction (2015) (0)
Fluorescence correlation microscopy study of protein interactions in the cell (2004) (0)
The use of fast genotypic drug resistance tests in the decision on chemoprophylaxis after occupational exposure to HIV (1997) (0)
Lentiviral vector-based animal models for neurodegenerative diseases (2003) (0)
Acknowledgement to Reviewers (2002) (0)
Evaluation of a novel delivery strategy for pulmonary gene transfer in a fetal mouse model using AAV6.2 (2009) (0)
Synthesis and preliminary biological evaluation of iodine-123labeled bicyclic nucleoside analogue (BCNA) as potential SPECT probe for varicella-zoster virus thymidine kinase (VZV-tk) reporter gene imaging (2007) (0)
WS09.2 Elexacaftor combinations (partially) restore CFTR function to previously drug-refractory mutations G85E and N1303K (2021) (0)
Tracking of ferritin-labeled endogenous neuroblast migration in mouse brain with MRI (2011) (0)
Reduction of the immunogenicity of a lentiviral vector using miRNA target sequences: evaluation of the effect of injection site in a mouse model (2007) (0)
Proof of principle: Imaging of suicide gene therapy for glioblastoma (2014) (0)
Human immunodeficiency virus gp120 as the primary target of action of AR177 (Zintevir) (1997) (0)
Small molecules targeting protein-protein interactions: A promising anti-HIV strategy (2010) (0)
Characterization of the integrase complexes in human cells expressing HIV-1 IN (2001) (0)
In vivo multi-modal imaging of a rat model for Parkinson’s disease: high resolution micro-MRI, micro-SPECT and micro-CT (2004) (0)
Retargeting of lentivector integration out of genes by transient expression of LEDGF/p75 chimera functionally rescues a cell culture model of X-linked chronic granulomatous disease (2012) (0)
Figure S1: HIV-1 reduces PHF13 expression in SupT1 and Jurkat-TAg cells from Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication (2017) (0)
Imaging of alpha-synuclein oligomerization in mouse brain with split firefly luciferase reporters (2013) (0)
Design of cell-permeable nanoneedles as HIV-1 integrase inhibitors (2011) (0)
LEDGF/p75 based gene therapy for HIV/AIDS (2011) (0)
The LEDGINs: first-in-class allosteric HIV-1 integrase inhibitors with potential pre-clinical development (2011) (0)
Dose-dependent therapeutic effects of FK506 on dopaminergic neurodegeneration and neuroinflammation in a viral vector-based α-synuclein rat model for Parkinson’s disease (2013) (0)
Can ELISA replace immunofluorescence for the serodiagnosis of Epstein-Barr virus infection? (1997) (0)
DNA Damage and Cellular Stress Responses TheStressOncoprotein LEDGF / p 75 Interactswith theMethyl CpG Binding Protein MeCP 2 and In fl uences Its Transcriptional Activity (2012) (0)
Virus evolution reveals an exclusive role for LEGDF/P75 in HIV replication (2007) (0)
Identification and validation of cofactors (2015) (0)
Isolation and characterization of clinical HIV-1 strains with different sensitivities to TIBO derivatives (1993) (0)
Overexpression of HIV-1 integrase in CEM cells interferes with HIV-1 replication: a potential new gene therapeutic approach for AIDS (2001) (0)
HIV replication in a human LEDGF/p75 knockout cell line reveals a role for HRP-2 (2012) (0)
WS06.03 Novel CFTR modulator combinations maximise functional rescue of G85E and N1303K in rectal organoids (2022) (0)
Non-invasive imaging of neurodegeneration and neuroinflammation in an alpha-synuclein-based rat Parkinson model (2014) (0)
Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles (2020) (0)
Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites (2013) (0)
Long-term bioluminescence imaging of lentiviral vector-mediated gene expression in mouse brain (2005) (0)
Transduction of human pulmonary epithelial cell lines with a lentiviral vector (2006) (0)
Development of new imaging reporter gene viral vectors (2008) (0)
Targeting mixed lineage leukemia by functional interference with the lens epithelial-derived growth factor (LEDGF/p75) (2012) (0)
rAAV2/5-based gene therapy model for cystic fibrosis (2014) (0)
Amniotic fluid derived mesenchymal stem cells for perinatal therapeutic applications (2012) (0)
Therapeutic effects of FK506 in an optimized AAV-based rat model for α-synucleinopathy (2011) (0)
The pharmaceutical composition and method for the treatment of retroviral infections (2001) (0)
HIV-1 integrase variants retarget viral integration on both a local as well as on a global scale (2014) (0)
Reduced nuclear import of HIV carrying the transportin-SR2 interaction mutant INR263A/K264A (2014) (0)
Viral vector-mediated RNA interference for gene knock-down in cell culture and in vivo (2011) (0)
Comparison and evaluation of [18F]-FDG and [18F]-FLT response in B-cell lymphoma mice treated with cytotoxic or antiproliferative agents (2010) (0)
Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection (2022) (0)
Role of Transportin-SR2 (Transportin-3, TRN-SR2, TNPO3) in HIV replication (2015) (0)
Solution-Phase Parallel Synthesis of New DKA-Analogues as HIV-1 IN-Inhibitors. (2006) (0)
The type 2 cannabinoid receptor as a new PET reporter gene for the brain (2010) (0)
Multi-modal imaging of therapeutic HSVtk expressing stem cells for glioma treatment (2012) (0)
Characterizing rAAV2 pseudotyped vectors for optogenetics applications in the primary visual cortex of the mouse (2015) (0)
The use of LEDGF/p75 chimera to retarget lentiviral integration (2011) (0)
Proceedings of the Frontiers of Retrovirology Conference 2016 (2016) (0)
HIV entry as target for the gene therapy of HIV infection (2002) (0)
Bioluminescence Imaging of Stroke-1 Induced Endogenous Neural Stem (2014) (0)
Inhibition of the IN-LEDGF/p75 interplay by LEDGINs reduces reactivation from latency (2016) (0)
Viral vectors as a tool to express optogenetics-related proteins in the brain (2014) (0)
Lentiviral Integration and the Role of the Cellular Cofactors LEDGF/p75 of the Cellular Cofactors LEDGF/p75 and Transportin-SR2 (2010) (0)
Evaluation of immune response and neuroinflammation after lentiviral vector-mediated gene transfer into adult rodent brain (2001) (0)
Unraveling the targeting mechanism of HIV integration (2012) (0)
The TIBO-site on HIV-1 reverse transcriptase represents a new target for anti-HIV chemotherapy (1991) (0)
HIV-1 integrase inhibitors monitored with surface plasmon resonance technology (1996) (0)
LEDGF/p75 as antiviral target for HIV gene therapy (2010) (0)
Generation of transgenic rats using lentiviral vector technology (2009) (0)
Interaction of HIV-1 integrase with human integrase interactor 1 (INI1) in vivo (2002) (0)
Combined non-invasive bioluminiscence and magnetic resonance imaging improves detection after pulmonary gene transfer in a fetal mouse model (2009) (0)
Inhibition of HIV-1 replication and integrase activity by a series of diketo derivatives (2001) (0)
Screening for inhibitors of the LEDGF/p75 HIV-1 IN interaction: a high throughput screening approach (2009) (0)
Virus evolution reveals an exclusive role for LEDGF/p75 in HIV (2006) (0)
Bioluminescence imaging of lentiviral vector-mediated locoregional gene transfer into adult mouse brain (2005) (0)
Comparative analysis of multiple AAV vector serotypes in the mouse brain (2007) (0)
Stable knockdown of gene expression by lentiviral vector-mediated delivery of short hairpin RNA as a tool to study neurodegenerative diseases (2004) (0)
Interactions of DNA and HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy (2003) (0)
Comparison of bicistronic lentiviral vectors expressing multiple imaging reporters (2007) (0)
Immunotherapy for malignant glioma using lentivirally transduced dendritic cells in an experimental murine model (2008) (0)
Neuroprotective effect of Parkin in rodent models for Parkinson’s (2005) (0)
LEDGF/p75 is critical but not essential for multiple round replication of HIV-1 in human knockout cells (2010) (0)
HIV-1 integrase in a test tube and living cells as studied by fluorescence correlation spectroscopy (FCS) (2002) (0)
439: Intra-amniotic VEGF administration in fetal rats with nitrofen induced lung hypoplasia – A placebo controlled study (2008) (0)
Comparison of differently pseudotyped lentiviral vectors for gene transfer in fetal mouse lung (2008) (0)
Optogenetic reinforcement of long-term potentiation in acute hippocampal slices (2014) (0)
Retargeting of lentivector integration by LEDGF/p75 chimera functionally rescues a cell culture model for X-linked CGD (2012) (0)
Transient expression of LEDGF-chimera results in retargeted and safer lentiviral vector integration (2013) (0)
Over-expression of the LEDGF/p75 integrase binding domain abrogates HIV replication (2006) (0)
Comparison of different rAAV serotypes for transduction of dopaminergic neurons in rat substantia nigra (2009) (0)
Broad-spectrum antiviral activity of polyoxometalates against human immunodeficiency virus and other enveloped viruses (1992) (0)
Multiple Mutations in Human Immunodeficiency Virus-1 Integrase Confer Resistance to the Pyranodipyrimidine V-165 (2004) (0)
Distinct layer-specific eGFP-expression patterns of different AAV2/7 viral vector promoters in primate V1 (2013) (0)
Optical imaging in experimental models of Parkinson's disease (2009) (0)
Selection of antiviral resistance against diketo derivatives, authentic inhibitors of HIV-1 integration (2001) (0)
Potent inhibition of HIV-1 replication by over-expression of the integrase binding domain of LEDGF/p75 (2006) (0)
High level expression of HIV-1 integrase in eukaryotic cells (1998) (0)
Residual HIV-1 replication is observed in the absence of LEDGF/p75 but remains sensitive to inhibition by LEDGIN (2011) (0)
Three versatile and practical synthetic strategies toward the development of novel HIV-1 integrase inhibitors (2011) (0)
416: Amniotic fluid derived mesenchymal stem cells as delivery vehicles for therapeutic factors (2011) (0)
Interaction of TRN-SR 2 with Ran 1 Interaction of Transportin-SR 2 with Ras-related nuclear protein ( Ran ) GTPase * (2013) (0)
Computational approaches for the identification of small molecules as inhibitors of HIV-1 in-LEDGF/p75 interactions (2011) (0)
P318: A DUAL ROLE FOR PSIP1 IN T-ALL (2022) (0)
2.113 A role for PINK1 in mitochondrial dynamics and mitochondrial function (2007) (0)
Oligomeric state of HIV-1 in: stable integrase, tetramers in human cell (2002) (0)
rAAV transduction in the myenteric and submucous plexus of mouse ileum and colon (2015) (0)
Cellular cofactors of HIV integrase: from target identification to discovery of ledgins (2011) (0)
Molecular sieve activity of the nuclear pore during HIV-1 nuclear import revealed by single virus analysis (2014) (0)
Evaluation of LV and AAV vector systems for stable delivery of MRI reporter genes to the rodent brain (2009) (0)
DJ-1 loss-of-function affects adult neurogenesis in rodent brain (2013) (0)
Characterization of TRN-SR2 mediated nuclear import of HIV (2009) (0)
Supplementary material from "Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication" (2017) (0)
From HIV to Leukemia: targeting MLL-fusion mediated acute leukemia through LEDGF/p75 (2013) (0)
HIV-1 integrase/Pol recruits LEDGF/p75 into viral particles (2014) (0)
rAAV2/5 encoding flag-tagged truncated CFTR for optimal pulmonary gene therapy for cystic fibrosis (2011) (0)
Highly Potent andSelective Inhibition ofHumanImmunodeficiency Virus bytheBicyclam Derivative JM3100 (1994) (0)
Potent and highly selective HIV-1 specific inhibition by a new series of phenylacetamide derivatives targeted at HIV-1 RT (1992) (0)
Corrigendum to “The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy”: [Virology 435 (1) (2013) 102–109] (2013) (0)
LEDGF/p75 qualifies as a cellular target for anti-HIV therapy (2011) (0)
Establishment of an in vitro assay system for HIV-1-induced neural cell death and inhibition thereof (2002) (0)
Validation of LEDGF/p75 as an important co-factor of lentiviral integration (2005) (0)
The V165I and T206S/S230N mutations in Human Immunodeficiency Virus-1 integrase confer resistance to the pyranodipyrimidine V-165 and reduce replication capacity (2005) (0)
Editorial Board (2019) (0)
TIBO derivatives represent a new lead of potent and selective HIV-1 inhibitors that interact with a reverse transcriptase-associated process (1990) (0)
Longitudinal follow-up and characterization of a robust rat model for Parkinson’s disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Authors: (2015) (0)
Highly selective and potent inhibition of human immunodeficiency virus (HIV) by the novel bicyclam derivative JM3100 (1993) (0)
Gene transfer into neuronal cells using lentiviral vectors (1999) (0)
A conserved interaction motif found in all LEDGF/p75 binding proteins is mimicked by HIV integrase (2015) (0)
Potent and highly selective HIV-1 specific inhibition by a new series of alfa-anilino phenyl acetamide (alfa-APA) derivatives targeted at HIV-1 reverse transcriptase (1992) (0)
Design, Synthesis and Anti-HIV Activity of Some Novel Isatin Derivatives (2007) (0)
Microwave‐Assisted Palladium‐Catalyzed Heterogeneous Vinylation of 2(1H)‐Pyridones. (2010) (0)
The domesticated transposase POGz is a cellular binding partner of LEGDF/p75 (2008) (0)
Quantitative bioluminescence imaging of lentiviral vector-labeled endogenous neural stem cells in mouse brain (2008) (0)
HIV-1 Integrase Inhibitors as anti-AIDS agents: Structure-Activity Relationships (SAR) of new Diketo Acids and Analogs. (2007) (0)
2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance (2013) (0)
Development of a robust alpha-synuclein-based rat model for Parkinson’s disease (2012) (0)
Resistance pathway analysis of diketo acid-based integrase inhibitors allows mapping and prediction of chemical properties of integrase inhibitors (2008) (0)
In vivo multimodal and quantitative micro-imaging of the 6-hydroxydopamine rat model of Parkinson's disease (2005) (0)
WS13-1 CFTR processing mutations cause distinct trafficking and functional defects (2019) (0)
Lentiviral vector based lineage tracing of hippocampal neural progenitor cells in the adult mouse brain (2013) (0)
Delivery of rAAV2/5 to fetal rather than neonatal murine airways allows successful readministration of viral vectors in adult life (2012) (0)
Comparison of lentiviral and adeno-associated viral vectors for stable MRI reporter gene expression in the rodent brain (2009) (0)
BET-independent MLV integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesis (2022) (0)
241: Effects of tracheal occlusion and albumin on proliferation in fetal rats with nitrofen induced congenital diaphragmatic hernia – A placebo controlled molecular study (2008) (0)
Transportin-SR2 and HIV-1 integrase, partners for HIV nuclear import (2011) (0)
Role of LEDGF/p75 in cell biology and disease pathogenesis (2015) (0)

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