Zena Werb

Q: What Schools Are Affiliated With Zena Werb

Zena Werb is affiliated with the following schools: University of Oxford, Rockefeller University, University of Toronto, University of California, San Francisco

Zena Werb's AcademicInfluence.com Rankings

Zena Werb

Biology

#1088

World Rank

#1872

Historical Rank

#569

USA Rank

Cell Biology

#20

World Rank

#22

Historical Rank

#11

USA Rank

biology Degrees

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Biology

Why Is Zena Werb Influential?

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According to Wikipedia, Zena Werb was a professor and the Vice Chair of Anatomy at the University of California, San Francisco. She was also the co-leader of the Cancer, Immunity, and Microenvironment Program at the Hellen Diller Family Comprehensive Cancer Center and a member of the Executive Committee of the Sabre-Sandler Asthma Basic Research Center at UCSF. Her research focused on features of the microenvironment surrounding cells, with particular interest in the extracellular matrix and the role of its protease enzymes in cell signaling.

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Zena Werb's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Inflammation and cancer (2002) (5987)
New functions for the matrix metalloproteinases in cancer progression (2002) (5930)
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010) (4221)
How matrix metalloproteinases regulate cell behavior. (2001) (3911)
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis (2000) (2727)
Remodelling the extracellular matrix in development and disease (2014) (2691)
Matrix metalloproteinases and the regulation of tissue remodelling (2007) (2578)
The extracellular matrix: A dynamic niche in cancer progression (2012) (2526)
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation (1999) (2004)
Lifeact: a versatile marker to visualize F-actin (2008) (1985)
Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand (2002) (1846)
MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes (1998) (1786)
Extracellular matrix degradation and remodeling in development and disease. (2011) (1646)
Netting neutrophils in autoimmune small-vessel vasculitis (2009) (1380)
A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1376)
Implantation and the placenta: key pieces of the development puzzle. (1994) (1363)
ECM and Cell Surface Proteolysis: Regulating Cellular Ecology (1997) (1347)
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis (2000) (1345)
Matrix metalloproteinases: effectors of development and normal physiology. (2000) (1265)
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix (1995) (1255)
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability (2005) (1231)
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression (1989) (1133)
Regulation of matrix biology by matrix metalloproteinases. (2004) (1104)
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? (2015) (1101)
Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. (1988) (1095)
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. (2008) (1078)
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor (1995) (1068)
Tumors as organs: complex tissues that interface with the entire organism. (2010) (1062)
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. (1999) (994)
Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018) (987)
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis (1999) (936)
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. (2012) (836)
Stromal Effects on Mammary Gland Development and Breast Cancer (2002) (827)
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. (2002) (826)
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. (2000) (807)
Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. (1982) (771)
92-kD type IV collagenase mediates invasion of human cytotrophoblasts (1991) (747)
The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. (2001) (701)
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells (2015) (695)
Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells (1997) (688)
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment (2002) (678)
Oxygen tension regulates the expression of angiogenesis factor by macrophages. (1983) (676)
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes (2006) (662)
Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. (1977) (651)
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland (2006) (640)
Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. (1988) (625)
Concepts of extracellular matrix remodelling in tumour progression and metastasis (2020) (621)
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013) (615)
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice (2004) (595)
Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones (2000) (592)
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. (2008) (586)
Matrix metalloproteinases and the development of cancer. (1996) (574)
ECM signalling: orchestrating cell behaviour and misbehaviour. (1998) (564)
Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. (1986) (562)
PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival (2005) (558)
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells (2003) (550)
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. (2010) (549)
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. (2009) (548)
Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin (2003) (489)
Elastase secretion by stimulated macrophages. Characterization and regulation (1975) (487)
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. (2007) (456)
Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events (2002) (455)
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. (1985) (446)
Circulating Tumor Cells (2013) (442)
Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution (1992) (437)
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. (2012) (416)
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. (1998) (411)
Secretory products of macrophages and their physiological functions. (1984) (410)
Secretion of a specific collagenase by stimulated macrophages (1975) (408)
Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans* (2002) (405)
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. (1992) (397)
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin (1995) (393)
Matrix remodeling during endochondral ossification. (2004) (387)
The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. (2001) (383)
The Serpin α1-Proteinase Inhibitor Is a Critical Substrate for Gelatinase B/MMP-9 In Vivo (2000) (375)
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes (2003) (373)
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium (2012) (370)
Novel method for studying mRNA phenotypes in single or small numbers of cells (1989) (369)
Altered fracture repair in the absence of MMP9 (2003) (361)
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752] (1994) (354)
Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. (1996) (350)
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. (1996) (349)
Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. (1996) (344)
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors (2002) (342)
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. (2008) (341)
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression (2013) (331)
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. (1995) (330)
Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages (1980) (317)
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. (2007) (317)
Tumour heterogeneity and metastasis at single-cell resolution (2018) (317)
Defective trophoblast function in mice with a targeted mutation of Ets2. (1998) (317)
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. (2003) (311)
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin (2005) (310)
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis (2003) (309)
Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils (2015) (304)
Hormonal and local control of mammary branching morphogenesis. (2006) (297)
MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices (2019) (293)
Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes (1999) (288)
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. (1992) (288)
Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity. (1986) (288)
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. (2003) (282)
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. (2012) (282)
Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. (1989) (281)
SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway (1993) (280)
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency (2002) (280)
Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. (1999) (280)
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter (2000) (274)
Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure (1999) (269)
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells (2003) (263)
Mice deficient in Ext2 lack heparan sulfate and develop exostoses (2005) (259)
Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8) (2007) (257)
Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions (1978) (256)
Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels (1986) (254)
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases (2002) (254)
GATA3 in development and cancer differentiation: Cells GATA have it! (2010) (253)
Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1 (1996) (250)
Blood‐spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing (2003) (249)
Mouse macrophage elastase. Purification and characterization as a metalloproteinase. (1981) (246)
Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid (1998) (245)
Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene (1996) (243)
The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts. (1994) (236)
Impaired wound contraction in stromelysin-1-deficient mice. (1999) (235)
Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. (2001) (231)
Candidate regulators of mammary branching morphogenesis identified by genome‐wide transcript analysis (2006) (227)
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9–mediated progenitor cell mobilization (2005) (227)
New functional roles for non-collagenous domains of basement membrane collagens (2002) (227)
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1 (2006) (224)
Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. (1992) (224)
Matrix Metalloproteinase-2 Facilitates Wound Healing Events That Promote Functional Recovery after Spinal Cord Injury (2006) (222)
Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment (2004) (221)
Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts (1984) (221)
Inflammatory Cells and Cancer (2001) (220)
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines (2004) (220)
Extracellular Matrix Degradation (1991) (216)
Inflammatory Cells and Cancer: Think Different! (2001) (214)
Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin (1982) (213)
Location, location, location: the cancer stem cell niche. (2007) (213)
Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution (2001) (210)
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity (2018) (208)
Proteinases in bone resorption: obvious and less obvious roles. (2000) (208)
Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells. (1998) (204)
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. (2013) (201)
How Proteases Regulate Bone Morphogenesis (2003) (200)
Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. (1992) (199)
Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information (1992) (199)
Interaction of glucocorticoids with macrophages. Identification of glucocorticoid receptors in monocytes and macrophages (1978) (198)
Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase. (1985) (197)
Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. (1991) (196)
Patterning Mechanisms of Branched Organs (2008) (195)
Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. (2000) (194)
Proteinases and extracellular remodeling (1989) (194)
Impaired lung branching morphogenesis in the absence of functional EGF receptor. (1997) (194)
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. (2010) (192)
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. (2009) (192)
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. (2002) (192)
Expression and function of FGF-4 in peri-implantation development in mouse embryos. (1994) (191)
Synergistic Transcriptional Activation of the Tissue Inhibitor of Metalloproteinases-1 Promoter via Functional Interaction of AP-1 and Ets-1 Transcription Factors (*) (1996) (190)
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. (2005) (190)
Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. (1972) (190)
Contribution of host MMP‐2 and MMP‐9 to promote tumor vascularization and invasion of malignant keratinocytes (2005) (188)
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008) (188)
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. (2008) (188)
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases (2003) (187)
Gelatinase B: Structure, Regulation, and Function (1998) (187)
Extracellular Matrix Remodeling during Morphogenesis a (1998) (187)
Isolation of a nonmitogenic angiogenesis factor from wound fluid. (1982) (186)
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. (2007) (182)
MMP‐2 and MMP‐9 synergize in promoting choroidal neovascularization (2003) (179)
A Cellular Striptease Act (1998) (176)
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. (2008) (175)
Elastases and elastin degradation. (1982) (175)
Matrix‐degrading proteases and angiogenesis during development and tumor formation (1999) (173)
Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture (1986) (173)
The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. (1974) (171)
Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. (1998) (165)
STIMULATION BY ENDOCYTOSIS OF THE SECRETION OF COLLAGENASE AND NEUTRAL PROTEINASE FROM RABBIT SYNOVIAL FIBROBLASTS (1974) (163)
Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation1 (2006) (163)
Matrix metalloproteinases in stem cell regulation and cancer (2015) (160)
Misregulation of Stromelysin-1 Expression in Mouse Mammary Tumor Cells Accompanies Acquisition of Stromelysin-1-dependent Invasive Properties* (1997) (160)
GATA-3 and the regulation of the mammary luminal cell fate. (2008) (159)
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation (2001) (156)
Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. (1997) (155)
Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis (2008) (153)
A molecular switch for the orientation of epithelial cell polarization. (2014) (153)
Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. (1998) (153)
Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni. (1985) (153)
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. (2005) (153)
Role of Matrix Metalloproteinase 13 in Both Endochondral and Intramembranous Ossification during Skeletal Regeneration (2007) (152)
Rac 1 b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability (2009) (150)
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. (2006) (149)
Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor (1998) (147)
Shedding light on sheddases: role in growth and development. (2002) (143)
Matrix Metalloproteinase 9 Protects Mice from Anti–Glomerular Basement Membrane Nephritis through Its Fibrinolytic Activity (2001) (143)
Two alkaline phosphatase genes are expressed during early development in the mouse embryo. (1990) (142)
Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction (2013) (142)
Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease (2006) (140)
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. (2002) (139)
A specific collagenase from rabbit fibroblasts in monolayer culture. (1974) (138)
Characterization of the unusually rapid cell cycles during rat gastrulation. (1993) (137)
Macrophage-derived growth factors. (1992) (137)
Molecular genetics of implantation in the mouse. (1997) (136)
Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. (1982) (135)
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium (2012) (134)
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. (2013) (132)
Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. (1996) (132)
Plasminogen activation independent of uPA and tPA maintains wound healing in gene‐deficient mice (2006) (132)
Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer (2016) (130)
microRNA-mediated regulation of the tumor microenvironment (2013) (129)
Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord (2008) (128)
Lactational competence and involution of the mouse mammary gland require plasminogen. (2000) (125)
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing (2020) (125)
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression (2016) (125)
CHOLESTEROL METABOLISM IN THE MACROPHAGE III. INGESTION AND INTRACELLULAR FATE OF CHOLESTEROL AND CHOLESTEROL ESTERS (1972) (122)
Epidermal Growth Factor Receptor-deficient Mice Have Delayed Primary Endochondral Ossification Because of Defective Osteoclast Recruitment* (2004) (121)
Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture (1980) (120)
Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers (2016) (120)
The Significance of Matrix Metalloproteinases during Early Stages of Tumor Progression a (1998) (120)
Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals (1995) (118)
Coevolution of cancer and stromal cellular responses. (2005) (117)
Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes. (1987) (117)
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. (2010) (115)
The fibroblastic coconspirator in cancer progression. (2005) (115)
Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro (1992) (114)
Matrix metalloproteinase-9 contributes to choroidal neovascularization. (2002) (112)
Role of c-kit/Kit ligand signaling in regulating vasculogenesis (2003) (112)
The Low Affinity IgE Receptor (CD23) Is Cleaved by the Metalloproteinase ADAM10* (2007) (111)
Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells. (1990) (110)
Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation (1983) (110)
Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins. (1993) (109)
Proteinases and extracellular matrix remodeling. (1989) (108)
Balancing the innate immune system in tumor development. (2015) (105)
Degradation of connective tissue matrices by macrophages. II. Influence of matrix composition on proteolysis of glycoproteins, elastin, and collagen by macrophages in culture (1980) (105)
The Role of Stroma in Tumor Development. (2015) (104)
Multiple trophic actions of heparin‐binding epidermal growth factor (HB‐EGF) in the central nervous system (1999) (103)
Limited proteolysis by macrophage elastase inactivates human alpha 1- proteinase inhibitor (1980) (103)
A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte (2003) (102)
Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1. (1995) (102)
Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation (2010) (101)
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. (2018) (100)
Roles of the Innate Immune System in Mammary Gland Remodeling During Involution (2007) (100)
Proteases induce secretion of collagenase and plasminogen activator by fibroblasts. (1978) (100)
Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution. (1996) (99)
Platelet alpha-granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes. (1990) (98)
Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters. (1990) (96)
alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression. (1999) (96)
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. (2005) (96)
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. (2010) (96)
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. (2007) (94)
Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. (2005) (94)
How the macrophage regulates its extracellular environment. (1983) (92)
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity (2012) (90)
Gene Trap Disruption of the Mouse Heparan Sulfate 6-O-Endosulfatase Gene, Sulf2 (2006) (90)
Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation. (1997) (89)
Mfge8 is critical for mammary gland remodeling during involution. (2005) (88)
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. (2011) (87)
Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. (2003) (86)
Matrix Metalloproteinases and Neurotrauma: Evolving Roles in Injury and Reparative Processes (2010) (86)
A role for niches in hematopoietic cell development (2005) (85)
Stromal regulation of vessel stability by MMP14 and TGFβ (2010) (84)
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression (2010) (84)
Comparative Mechanisms of Branching Morphogenesis in Diverse Systems (2006) (83)
Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. (2012) (82)
Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes (1983) (81)
Expression of EGF and TGF‐α genes in early mammalian development (1990) (81)
Tumor-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression (2020) (81)
MMP9 regulates the cellular response to inflammation after skeletal injury. (2013) (80)
CHOLESTEROL METABOLISM IN THE MACROPHAGE : II. ALTERATION OF SUBCELLULAR EXCHANGEABLE CHOLESTEROL COMPARTMENTS AND EXCHANGE IN OTHER CELL TYPES (1971) (80)
Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. (2001) (80)
MMP9 and SCF protect from apoptosis in acute kidney injury. (2009) (79)
Apoprotein E is synthesized and secreted by resident and thioglycollate- elicited macrophages but not by pyran copolymer- or bacillus Calmette- Guerin-activated macrophages (1983) (79)
Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations (2014) (78)
Molecular determinants of lung development. (2013) (76)
Monitoring of vital signs for long-term survival of mice under anesthesia. (2011) (76)
EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. (1993) (76)
Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. (1971) (76)
Secretion of macrophage neutral proteinase is enhanced by colchicine. (1976) (75)
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. (2008) (74)
Endotoxin suppresses expression of apoprotein E by mouse macrophages in vivo and in culture. A biochemical and genetic study. (1983) (74)
Journey Across the Osteoclast (1997) (73)
High-resolution three-dimensional views of membrane-associated clathrin and cytoskeleton in critical-point-dried macrophages (1983) (73)
Adaptive Immune Regulation of Mammary Postnatal Organogenesis. (2015) (73)
A functional overlap of plasminogen and MMPs regulates vascularization during placental development (2003) (73)
TIMP-1 promotes VEGF-induced neovascularization in the retina. (2001) (73)
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. (2006) (72)
A whole organism screen identifies novel regulators of fat storage (2011) (72)
Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors (2003) (71)
Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis. (1996) (70)
The apical ectodermal ridge is a timer for generating distal limb progenitors (2008) (70)
Discoidin Domain Receptor 2 Mediates Tumor Cell Cycle Arrest Induced by Fibrillar Collagen* (2005) (70)
Targeted Expression of Stromelysin-1 in Mammary Gland Provides Evidence for a Role of Proteinases in Branching Morphogenesis and the Requirement for an Intact BasementMembrane for Tissue-specific Gene Expression (2002) (69)
The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. (2007) (69)
Proliferative synovitis in hemophilia: biochemical and morphologic observations. (1978) (68)
Collagenase is a major gene product of induced rabbit synovial fibroblasts (1984) (68)
Roadblocks to translational advances on metastasis research (2013) (68)
Regulation of extracellular matrix degradation by cell-extracellular matrix interactions. (1990) (68)
Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression. (2000) (67)
The labyrinthine placenta (2000) (65)
Secretory products of phagocytes. (1988) (65)
Glucocorticoid receptors and glucocorticoid-sensitive secretion of neutral proteinases in a macrophage line. (1978) (64)
Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2 (2010) (64)
Metalloproteases and adipogenesis: a weighty subject. (2002) (63)
HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice (2018) (63)
Prognostic Value of PAI1 in Invasive Breast Cancer: Evidence That Tumor-Specific Factors Are More Important Than Genetic Variation in Regulating PAI1 Expression (2006) (61)
Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. (1981) (61)
Matrix Metalloproteinase-9 and Stromal Cell-Derived Factor-1 Act Synergistically to Support Migration of Blood-Borne Monocytes into the Injured Spinal Cord (2011) (60)
MULTI-seq: Scalable sample multiplexing for single-cell RNA sequencing using lipid-tagged indices (2018) (60)
Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring (2006) (60)
Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis (1986) (59)
Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis (2008) (59)
Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection (2005) (59)
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues (2004) (59)
Kynurenic Acid Is a Nutritional Cue that Enables Behavioral Plasticity (2015) (58)
Collagenase expression and endogenous activation in rabbit synovial fibroblasts stimulated by the calcium ionophore A23187. (1988) (58)
Intravital imaging of stromal cell dynamics in tumors. (2010) (57)
Cooperative interactions between extracellular matrix, integrins and parathyroid hormone-related peptide regulate parietal endoderm differentiation in mouse embryos. (1995) (57)
Proteolysis and the biochemistry of life-or-death decisions (1996) (56)
Dual Targets for Mouse Mast Cell Protease-4 in Mediating Tissue Damage in Experimental Bullous Pemphigoid* (2011) (56)
Developmental Biology: Vasculogenesis is a Wreck Without RECK (2002) (56)
The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. (2012) (55)
Role of Collagen Type II and Perlecan in Skeletal Development (2003) (55)
Cytochalasin B increases collagenase production by cells in vitro (1975) (54)
Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. (1998) (51)
Stem cell defects in parthenogenetic peri-implantation embryos. (1995) (51)
Regulation of protein secretion in Chinese hamster ovary cells by cell cycle position and cell density. Plasminogen activator, procollagen fibronectin. (1982) (51)
Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. (2011) (51)
Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer (2019) (50)
Uterine and Vaginal Organ Growth Requires Epidermal Growth Factor Receptor Signaling from Stroma. (1998) (50)
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. (2020) (50)
RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth (2014) (49)
Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host. (1983) (48)
Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin. (1996) (48)
Active Plasma Kallikrein Localizes to Mast Cells and Regulates Epithelial Cell Apoptosis, Adipocyte Differentiation, and Stromal Remodeling during Mammary Gland Involution* (2009) (47)
Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis. (1992) (47)
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development (2007) (46)
Matrix metalloproteinases and their expression in mammary gland (1998) (46)
Expression of apolipoprotein E by mouse brain astrocytes and its modulation by interferon-γ (1987) (46)
Protective effects of matrix metalloproteinase-12 following corneal injury (2013) (46)
Expression and function of matrix metalloproteinases in development. (1992) (45)
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy (2019) (45)
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling (2017) (45)
Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos (1997) (44)
Minireview: Parthenogenesis in mammals (2001) (44)
Phorbol diesters regulate expression of the membrane neutral metalloendopeptidase (EC 3.4.24.11) in rabbit synovial fibroblasts and mammary epithelial cells. (1989) (43)
Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. (2005) (43)
Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers (2018) (43)
New insights into saccular development and vascular formation in lung allografts under the renal capsule (2003) (42)
Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice (2006) (42)
Rapid fragmentation and reorganization of Golgi membranes during frustrated phagocytosis of immobile immune complexes by macrophages. (1989) (42)
Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals (2016) (41)
Mammary gland reprogramming: metalloproteinases couple form with function. (2011) (39)
Innate and acquired immune surveillance in the postdissemination phase of metastasis (2018) (39)
SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling (2016) (39)
Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endoderm differentiation of embryonal carcinoma cells. (1990) (39)
Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells (2017) (38)
MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. (2012) (36)
Dual Protective Mechanisms of Matrix Metalloproteinases 2 and 9 in Immune Defense against Streptococcus pneumoniae (2011) (36)
Cooperative Signaling by and a4/ l Integrins Regulates Metalloproteinase Gene Expression in Fibroblasts Adhering to Fibronectin (2002) (36)
Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages (1984) (35)
Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo. (1994) (34)
Biologic potential of pulmonary macrophages. (1978) (34)
Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice. (2001) (34)
Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury (2003) (34)
GATA3 Targets Semaphorin 3B in Mammary Epithelial Cells to Suppress Breast Cancer Progression and Metastasis (2017) (32)
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. (2009) (32)
Matrix Metalloproteinase 13 Is Induced in Fibroblasts in Polyomavirus Middle T Antigen-Driven Mammary Carcinoma without Influencing Tumor Progression (2008) (32)
Collagenase and other proteinases in the cornea of the retinol-deficient rat (1975) (31)
Efficacy of a Metalloproteinase Inhibitor in Spinal Cord Injured Dogs (2014) (31)
Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells (1985) (31)
Regulation of alpha 1 proteinase inhibitor function by rabbit alveolar macrophages. Evidence for proteolytic rather than oxidative inactivation. (1985) (30)
Neutrophils: Critical components in experimental animal models of cancer. (2016) (30)
Preparation of mice for long-term intravital imaging of the mammary gland. (2011) (30)
Cellular architecture of human brain metastases (2021) (30)
mRNA phenotyping for studying gene expression in small numbers of cells: platelet-derived growth factor and other growth factors in wound-derived macrophages. (1990) (30)
α1 and α2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression (1999) (29)
Proteinases, cell cycle regulation, and apoptosis during mammary gland involution (minireview) (2000) (29)
Purification and properties of a specific collagenase from rabbit synovial fibroblasts. (1975) (29)
Tissue inhibitor of metalloproteinases. Identification of precursor forms synthesized by human fibroblasts in culture. (1985) (29)
The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion* (2014) (29)
Degradation of extracellular matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomula. (1983) (29)
Selective proteolysis of immunoglobulins by mouse macrophage elastase (1983) (27)
ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression (2017) (27)
Directed exocytosis of secretory granules containing apolipoprotein E to the adherent surface and basal vacuoles of macrophages spreading on immobile immune complexes. (1989) (26)
Biology and Regulation of the Matrix Metalloproteinases (2001) (26)
Expression in Fibroblasts (2003) (26)
Paracrine mechanisms of mouse mammary ductal growth. (2000) (26)
Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G (1984) (25)
p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK–myosin-II pathway (2015) (25)
Mapping mammary gland architecture using multi-scale in situ analysis. (2009) (25)
Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis (2018) (25)
Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials. (1976) (25)
Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling? (1992) (24)
Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. (1978) (24)
LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target (2020) (24)
Prognostic Value of PAI 1 in Invasive Breast Cancer : Evidence That Tumor-Specific Factors Are More Important Than Genetic Variation in Regulating PAI 1 Expression (2006) (24)
Human synovial dendritic cells. Direct observation of transition to fibroblasts. (1985) (23)
Lectin binding to guinea-pig sperm zipper particles. (1983) (23)
A Multilevel Model of Postmenopausal Breast Cancer Incidence (2014) (23)
Metalloproteinases: a Functional Pathway for Myeloid Cells. (2016) (22)
The role of stromelysin-1 in stromal-epithelial interactions and cancer. (1996) (22)
[15] Elastin degradation (1987) (22)
Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts. (1992) (22)
Elastin degradation. (1987) (21)
Functional analysis of trophoblast giant cells in parthenogenetic mouse embryos. (1997) (21)
Integrins, Signaling, and the Remodeling of the Extracellular Matrix (1994) (21)
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients (2016) (21)
Expression of the catalytic activity of plasminogen activator under physiologic conditions. (1981) (21)
The cell and molecular biology of apolipoprotein E synthesis by macrophages. (1986) (21)
Factor B, the complement alternative pathway serine proteinase, is a major constitutive protein synthesized and secreted by resident and elicited mouse macrophages (1985) (20)
The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo (1995) (20)
CHOLESTEROL METABOLISM IN THE MACROPHAGE (1971) (19)
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium (2012) (18)
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant. (1999) (18)
T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40. (1996) (17)
Oncogenes and cell proliferation: Maintenance of genome integrity, tumor stem cells, and the somatic microenvironment (2004) (17)
Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord (2016) (17)
Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts. (1995) (17)
Defective induction of the transcription factor interferon-stimulated gene factor-3 and interferon alpha insensitivity in human trophoblast cells. (1999) (17)
Expression of EGF and TGF-alpha genes in early mammalian development. (1990) (16)
Immunochemical studies with a specific antiserum to rabbit fibroblast collagenase. (1975) (16)
An irreversible tissue inhibitor of collagenase in human amniotic fluid: characterization and separation from fibronectin. (1981) (16)
In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding (2013) (16)
Cell-to-cell contact and extracellular matrix cell adhesion and the extracellular matrix: recent progress and emerging themes (1998) (15)
Invasion and metastasis—recent advances and future challenges (2015) (15)
Leveraging microenvironmental synthetic lethalities to treat cancer. (2021) (14)
Proteinase induction by endothelial cells during wound repair. (1988) (14)
Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade. (2001) (14)
Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. (2011) (14)
The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. (2015) (13)
Induction of c‐fos transcripts in early postimplantation mouse embryos by tgf‐α, EGF, PDGF, and FGF (1991) (13)
Animal Models of Corneal Injury. (2015) (12)
Hormone Receptors and Hormonal Regulation of Macrophage Physiological Functions (1980) (12)
Expression and Function of Growth Factor Ligands and Receptors in Preimplantation Mouse Embryos (1991) (12)
Macrophage secretions: a functional perspective (1989) (11)
Rabbit collagenase. Immunological identity of the enzymes released from cells and tissues in normal and pathological conditions. (1975) (11)
A model of intussusceptive angiogenesis. (2007) (11)
Effects of Imprinting on Early Development of Mouse Embryos (1993) (10)
The Role of Growth Factors in Mammalian Pregastrulation Development (1994) (10)
BIOSYNTHETIC RADIOLABELING OF CELLULAR AND SECRETED PROTEINS OF MONONUCLEAR PHAGOCYTES (1981) (10)
Epithelial Morphogenesis: Netrin Comes to a Sticky and Terminal End (2003) (9)
62 – ELASTINOLYTIC ENZYMES (1981) (9)
Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors (2015) (9)
Chapter 54 The role of macrophage-derived growth factors in tissue repair (1992) (9)
Functional interplay between extracellular matrix and extracellular matrix-degrading proteinases in the mammary gland: a coordinate system for regulating mammary epithelial function (1992) (8)
Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels (2015) (8)
Analysis of Embryonic Cartilage and Bone Induction in a Defined Culture System (1990) (8)
Induction of c-fos transcripts in early postimplantation mouse embryos by TGF-alpha, EGF, PDGF, and FGF. (1991) (8)
Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome (2022) (8)
Morphogenesis : cellular interactions (1998) (7)
Suppression of ICE and apoptosis in mammary epithelial cells by the extracellular matrix and the cytoskeleton (1995) (7)
Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening (2020) (6)
Control of apolipoprotein E secretion by macrophages (1985) (6)
Phagocytosis by nonprofessional phagocytes (1999) (6)
Tumor cell-adipocyte gap junctions activate lipolysis and are essential for breast tumorigenesis (2018) (6)
The Transcription Factor ZNF 217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression (2012) (6)
Respiratory Defense Mechanisms (In Two Parts). Part I and Part II. Lung Biology in Health and Disease, Volume 5.Joseph D. Brain , Donald F. Proctor , Lynne M. Reid (1978) (6)
Corrigendum: Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes (2006) (6)
LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland (2022) (5)
CHARACTERIZATION AND CLASSIFICATION OF MACROPHAGE PROTEINASES AND PROTEINASE INHIBITORS (1981) (5)
Evidence that species specificity and rate of collagen degradation are properties of collagen, not collagenase. (1977) (5)
Development and regenerative ability of bladder in the transgenic epidermal growth factor receptor gene knockout mouse. (1997) (5)
Redistribution of Ecto‐5′‐Nucleotidase During Phagocytosis by Guinea Pig Polymorphonuclear Leukocytes (1984) (4)
Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules. (2020) (4)
Summary Development of the mammary gland requires DGAT 1 expression in stromal and epithelial tissues (2004) (4)
Summary Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT 1-MMP-mediated activation of gelatinase A / MMP 2 (4)
CSN 5 Isopeptidase Activity Links COP 9 Signalosome Activation to Breast Cancer Progression (2008) (4)
Expression of genes for growth factors and their receptors in preimplantation mouse embryos (1989) (4)
Cellular control of collagen breakdown in rheumatoid arthritis (2005) (4)
Summary Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM 17-dependent shedding of epithelial amphiregulin (3)
[33] The preparation of macrophage lysosomes and phagolysosomes (1974) (3)
Macrophage elastase: regulatory consequences of the proteolysis of non-elastin tissue substrates (1985) (3)
Ultrastructural aspects of phagocytosis by macrophages (1984) (3)
ECM and Cell Surface Proteolysis: Minireview Regulating Cellular Ecology (1997) (3)
Anti-Microbial Function of MMP2 and MMP9 Mediated through Activation of Innate Immunity in Response to Streptococcus pneumoniae. (2009) (3)
Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis (2008) (3)
G'rab'bing the microenvironment for invasion. (2007) (3)
The preparation of macrophage lysosomes and phagolysosomes. (1974) (3)
GROWTH OF MACROPHAGES ON COLLAGEN-, ELASTIN-, AND GLYCOPROTEIN-COATED PLATES AS A TOOL FOR INVESTIGATING MACROPHAGE PROTEINASES (1981) (3)
PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression (2016) (2)
Mosaic analysis reveals essential function of FGF receptor 2 in mammary gland branching morphogenesis (2006) (2)
Introduction: basic science aspects of breast cancer. (1995) (2)
Adaptive Immune Regulation of Mammary Postnatal Organogenesis Graphical (2015) (2)
Chapter 17 – The Tumor Microenvironment in Cancer Progression (2008) (2)
Capturing cancer stem cells (2008) (2)
Macrophage membranes and clathrin (1985) (2)
Production of a Specific Collagenase by Rabbit Synovial Cells in Continuous Cell Culture (1973) (2)
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin (2006) (2)
Zena Werb [interview by Fiona M Watt]. (2004) (2)
Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy. (2014) (1)
The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain. (2010) (1)
Cancer-associated ﬁbroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers (2016) (1)
Abstract IA24: How tumors regulate their microenvironment in primary sites and metastasis (2013) (1)
Pitfalls in ecto-5′-nucleotidase enzyme cytochemistry as demonstrated by the immunogold-labelling technique on macrophages (1988) (1)
Novel Functions for a Fibrinolytic Pathway in Controlling Hematopoiesis. (2007) (1)
Collagen-fibronectin interactions in normal and rous sarcoma virus-transformed avian tendon cells: Possible mechanisms for increased extracellular matrix turnover after transformation (1987) (1)
A genetic approach to identifying the functions of metalloproteinases and their inhibitors in adult and developing mice. (1992) (1)
The Joy of a Career in Cell Biology (2010) (1)
Tissue inhibitor of metalloproteinases is induced by nerve damage. (1992) (1)
CHOLESTEROL METABOLISM IN THE MACROPHAGE (1971) (1)
Inhibition of Specific Collagenase by α2-Macroglobulin (1973) (1)
Requirement of MMP2 and MMP9 for lung innate immune defense against Streptococcus pneumoniae infection (37.34) (2010) (1)
HSulf‐2, an Extracellular Endosulfatase, is Secreted by MCF‐7 Breast Carcinoma Cells and Selectively Mobilizes Heparin‐Bound VEGF, FGF‐1, and SDF‐1 (2006) (1)
Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis (2017) (1)
Low-Dose Irradiation Promotes Tissue Revascularization through Matrix Metalloproteinase-9 Mediated VEGF Release from Mast Cells. (2004) (1)
A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1)
An in vitro model of intussusceptive angiogenesis (2006) (1)
THE RELATION OF PHAGOCYTOSIS TO THE SECRETION OF NON-LYSOSOMAL ENZYMES BY CONNECTIVE TISSUE CELLS (1975) (1)
The metalloprotease kuzbanian mediates the transactivation of EGF receptor by G-protein coupled receptors (2001) (1)
Preface (1998) (0)
Growth factor genes are expressed during morphogenesis of the mouse first branchial arch (1989) (0)
Invasion and metastasis—recent advances and future challenges (2015) (0)
Metalloproteinase-9-deficient mice are resistant to bullous pemphigoid (1998) (0)
Tumour heterogeneity and metastasis at single-cell resolution (2018) (0)
Abstract 2475: Zpo2 promotes aggressive breast cancer development through downregulation of GATA3 (2014) (0)
Migration of CXCR6+ activated/memory T-cells is stopped in response to hypoxia. (2010) (0)
Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. (2015) (0)
LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target (2020) (0)
Abstract 4724: Targeting matrix metalloproteinases (MMP) for anti-metastatic therapy: Blocking active MMP9 abrogates metastatic niche formation and prevents metastatic seeding in a breast cancer model (2015) (0)
MMP-9 in mouse mammary cancer (2002) (0)
Abstract 2465: Matrix metalloproteinase 9 promotes breast cancer through regulation of insulin-like growth factor-binding proteins (2012) (0)
Carcinoma-associated fibroblasts in different tumor microenvironments. (2008) (0)
Streptococcus pneumoniae Defense against Metalloproteinases 2 and 9 in Immune Dual Protective Mechanisms of Matrix (2011) (0)
Abstract LB-055: Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancer (2018) (0)
Abstract 351: Alterations in immune cell signatures during breast cancer metastasis at single cell resolution (2020) (0)
MMP12 Regulation of Corneal Inflammation (2013) (0)
Macrophage Infiltration in Tumor Stroma Myeloid-Derived Suppressor Cell Expansion and the Tumor-Bone Marrow Axis Responsible for Mediated MMP-9 Inhibition Breaks − Amino-Biphosphonate (2007) (0)
MMPs as Regulators of Tumor Microenvironment (2015) (0)
CHOLESTEROL METABOLISM IN THE MACROPHAGE (1972) (0)
Matrix Dependent Mechanisms Involved in Tumor Promotion in Initiated Human Mammary Epithelium by Reactive Stroma (2000) (0)
Extravasation and stromal cell uptake of fluorescent dextran in tumors. (2010) (0)
Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development (2020) (0)
Role of Stem Cells in Environmental Risk for Breast Cancer (2010) (0)
Migration of CXCR6+ activated/memory T-cells in the tumor microenvironment. (2010) (0)
Induction of HB-EGF mRNA is intact in skin organ cultures of EGFR knockout mice (1998) (0)
Little is known about the dynamics of cancer cell death in response to therapy in the tumor microenvironment (2012) (0)
Macrophage membranes and clathrin 1 (0)
Engineering of Specific Tissue Inhibitors to Block ADAM Type Metalloprotease-Mediated Mammary Neoplasia (2001) (0)
Site-specific inductive and inhibitory activities of and orchestrate mammary gland branching (2010) (0)
Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia. (2008) (0)
pathway regulated by imprinting in early mouse embryos. Insulin-like growth factor II acts through an endogenous growth (2013) (0)
Binding of hormones and other biological messengers to macrophage receptors (1985) (0)
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity (2018) (0)
Regulation of angiogenesis by macrophages (1985) (0)
Single-cell analysis reveals a distinct stem cell program in early human metastatic breast cancer cells (2017) (0)
Myeloid cells extravasate and infiltrate late carcinoma lesions. (2009) (0)
The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface (1991) (0)
A Sticky Wicket: Opposing Functions of p120-Catenin in Development and Cancer (2011) (0)
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing (2020) (0)
Complement C 5 a Fosters S quamousCarcinogenesis and Limits T Cell Response to Chemotherapy Graphical (2018) (0)
Abstract IA11: New insights into the microenvironment and metastasis (2011) (0)
Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution (2022) (0)
Foxp3+ regulatory T cells migrate along blood vessels and at the tumor-stroma border. (2008) (0)
Gr1+ myeloid cells are a patrolling subpopulation of the tumor-infiltrating myeloid cells. (2008) (0)
Commentary Metalloproteases and Adipogenesis: A Weighty Subject (2002) (0)
Abstract 3807: Exposure to environmental chemicals leads to extensive branching and expression of cancer-promoting proteins in human mammary gland organoids (2020) (0)
Role of Macrophage Elastase (MMP12) in Corneal Myeloid Cell Activities Visualized With Time-lapse in vivo Confocal Microscopy (2011) (0)
Abstract IA24: A stem cell program in early human metastatic breast cancer cells (2016) (0)
68 Impairment of post-lactational involution of the mammary gland in mice deficient for the plasminogen gene (1997) (0)
Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment (2023) (0)
ExtracellularMatrixDegradationandRemodeling in Development and Disease (2013) (0)
Faculty Opinions recommendation of The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. (2002) (0)
Functional Characterization of Mammary Stem Cells (2004) (0)
Inflammationand 9 Reveals a Mechanism for Resolution of Substrates for Matrix Metalloproteinases 2 Proteomic Identification of In Vivo (2006) (0)
ID: 373 MMP-9-dependent regulation of angiogenesis and invasion in GBM (2006) (0)
Severe Inhibition of Choroidal Neovascularization in Mice With a Combined Deficiency of MMP-2 and MMP-9 Genes (2003) (0)
HIF signalling in skeletal progenitors promotes breast cancer growth and metastasis through systemic production of CXCL12 (2015) (0)
Tumor cell-adipocyte gap junctions activate lipolysis in breast cancer (2018) (0)
417 INVITED Matrix Metalloproteases and Remodelling of the Extracellular Matrix (2011) (0)
Molecular regulation of collective epithelial migration during mammary branching morphogenesis (2008) (0)
Novel Functions for a Fibrinolytic Pathway in Controlling the Stem Cell Niche. (2006) (0)
INTRACELLULAR FATE OF CHOLESTEROL AND CHOLESTEROL ESTERS* (2003) (0)
Abstract 964: Tumor cell plasticity promotes metastasis across heterogeneous tumors (2022) (0)
Abstract LB-122: PIM1 kinase inhibition halts the growth of MYC-overexpressing triple-negative breast tumors (2014) (0)
CD11c+ dendritic-like cells migrate at the tumor-stroma border. (2008) (0)
c-fms+ myeloid cells migrate in the normal mammary gland. (2008) (0)
Intraluminal Microtubule Acetylation Regulates Ocular Development and Corneal Repair (2016) (0)
Associated Fibroblasts and the Tumor Microenvironment − MicroRNAs Play a Big Role in Regulating Ovarian Cancer (2012) (0)
Glioma invasion: Identification of determinants of invasion using time‐lapse imaging (2008) (0)
Novel regulation of PDGFRα activation in Glioblastoma (2012) (0)
Abstract IA06: The tissue-specific microenvironment in primary tumors and metastases (2020) (0)
Matrix metaloproteases as proto-oncogenes (1997) (0)
Abstract B232: PIM1 kinase is essential for the growth of MYC-overexpressing triple-negative breast tumors and is an efficacious therapeutic target. (2013) (0)
Abstract B34: PIM kinase as a novel therapeutic target for triple-negative breast cancer (2016) (0)
Infiltration and migration of c-fms+ myeloid cells in the tumor microenvironment. (2008) (0)
From Normalcy to Neoplasia. The Role of Epithelial-Stromal Interactions in Regulating Mammary Growth and Differentiation (2000) (0)
Abstract IA2: Microenvironmental control of bone metastasis (2013) (0)
Erratum: Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice (Proceedings of the National Academy of Sciences of the United States of America (July 12, 2005) 102, 28 (9884-9889) doi 10.1073/pnas.0504391102) (2006) (0)
Symposium S09: MMPs in the Nervous System: Functions in Physiology, Pathology and Recovery (2003) (0)
Metalloproteinases mediate human cytotrophoblast invasion in vitro (1991) (0)
Corneal Development and Epithelial Wound Healing in Matrix Metalloproteinase 12-Deficient Mice (2009) (0)
Abstract SY02-02: Novel mechanisms regulating breast cancer progression, metastasis, and response to therapy (2010) (0)
Functional characterization of mammary stem cells in development and breast cancer (2003) (0)
Coordinated Expression of ECM-Degrading Proteinases and Their Inhibitors Regulates Functional Status of Mammary Epithelia During Involution (1991) (0)
Session 6: Stem Cells (2004) (0)
Secretion by stimulated murine macrophages of a heparin-binding fibroblast growth activity, distinct from basic FGE and IL-1 (1986) (0)
EGF stimulates growth of primary mamma epithelial cells from virgin or pregnant mice in vitro (1998) (0)
Streptococcus pneumoniae against Metalloproteinases 2 and 9 in Immune Defense Dual Protective Mechanisms of Matrix (2011) (0)
Title Invasion and metastasis — recent advances and future challenges (0)
Macrophage Metalloelastase (MMP12) Regulates Inflammation and Neovascularization Following Corneal Injury (2012) (0)
Hif1alpha leads to chondrodysplasia in MMP-deficient mice (2016) (0)
E11. The tumour microenvironment in breast cancer (2012) (0)
c-fms+ myeloid cells migrate in response to wounding on the surface of a normal mammary gland (2009) (0)
Abstract 198: Endovascular Biopsy: in vivo Brain Aneurysm Endothelial Cell Sampling and Gene Expression Analysis (2017) (0)
Abstract IA26: Regulation of metastasis in breast cancer (2013) (0)
PNAS Plus Significance Statements (2016) (0)
Two Cultures and the Revolution in Biotechnology (2004) (0)
Identification of MMP Substrates in the Mammary Gland (2003) (0)
Abstract IA09: Building the metastatic microenvironment (2015) (0)
How matrix metalloproteinases regulate signaling in cancer (2009) (0)

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