Zhong‐yin Zhang
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Chemistry Biology
Zhong‐yin Zhang's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry Peking University
Why Is Zhong‐yin Zhang Influential?
(Suggest an Edit or Addition)Zhong‐yin Zhang's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. (2007) (499)
- Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development. (2002) (395)
- Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate (1994) (368)
- Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B* (1999) (350)
- Structural and functional analysis of the costimulatory receptor programmed death-1. (2004) (349)
- Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects (2009) (268)
- Protein tyrosine phosphatases as potential therapeutic targets (2014) (244)
- PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity (2003) (238)
- The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases* (2002) (210)
- Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents (2010) (191)
- The Mechanism of Dephosphorylation of Extracellular Signal-regulated Kinase 2 by Mitogen-activated Protein Kinase Phosphatase 3* (2001) (187)
- Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion (2008) (178)
- Acquisition of a Specific and Potent PTP1B Inhibitor from a Novel Combinatorial Library and Screening Procedure* (2001) (169)
- PRL3 Promotes Cell Invasion and Proliferation by Down-regulation of Csk Leading to Src Activation* (2007) (167)
- Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). (2010) (162)
- Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling1 (2009) (154)
- Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases (2007) (146)
- Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis (2015) (142)
- Protein–tyrosine phosphatases: Structure, mechanism, and inhibitor discovery (1998) (137)
- Chemical and mechanistic approaches to the study of protein tyrosine phosphatases. (2003) (136)
- Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling. (2015) (129)
- A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. (2008) (124)
- Small molecule tools for functional interrogation of protein tyrosine phosphatases (2013) (124)
- Targeting PTPs with small molecule inhibitors in cancer treatment (2008) (124)
- Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. (2006) (123)
- Crystal Structure of PTP1B Complexed with a Potent and Selective Bidentate Inhibitor* (2003) (122)
- TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. (2011) (120)
- Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2* (2001) (116)
- Faculty Opinions recommendation of Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. (2009) (113)
- Therapeutic Targeting of Oncogenic Tyrosine Phosphatases. (2017) (111)
- PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. (2009) (110)
- Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain (2014) (110)
- Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. (2008) (109)
- Suramin Is an Active Site-directed, Reversible, and Tight-binding Inhibitor of Protein-tyrosine Phosphatases* (1998) (106)
- Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. (2006) (106)
- Cellular effects of small molecule PTP1B inhibitors on insulin signaling. (2003) (104)
- Modulation of protein kinase signaling by protein phosphatases and inhibitors. (2002) (103)
- Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases. (2017) (102)
- Mechanistic studies on protein tyrosine phosphatases. (2003) (101)
- Molecular Basis for Substrate Specificity of Protein-tyrosine Phosphatase 1B* (1998) (99)
- A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates* (2003) (96)
- Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase (2014) (94)
- Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations* (2013) (94)
- Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. (2009) (94)
- Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant. (2002) (93)
- ErbB3-dependent motility and intravasation in breast cancer metastasis. (2006) (90)
- Negative regulation of TLR signaling in myeloid cells—implications for autoimmune diseases (2016) (89)
- Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. (2012) (89)
- The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling* (2005) (89)
- Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. (2005) (87)
- A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells (2008) (87)
- Src Phosphorylates Cas on Tyrosine 253 to Promote Migration of Transformed Cells* (2003) (83)
- An overview of the protein tyrosine phosphatase superfamily. (2003) (82)
- Aurintricarboxylic Acid Blocks in Vitro and in Vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague* (2003) (81)
- A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation (2016) (80)
- Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. (2008) (77)
- Phosphatase Activity, Trimerization, and the C-terminal Polybasic Region Are All Required for PRL1-mediated Cell Growth and Migration* (2007) (75)
- The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis (2018) (73)
- Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation (2020) (73)
- Activity-based probes for protein tyrosine phosphatases. (2004) (70)
- Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein-tyrosine Phosphatase α* (1997) (69)
- Probing the Molecular Basis for Potent and Selective Protein-tyrosine Phosphatase 1B Inhibition* (2002) (69)
- Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug. (2007) (68)
- Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases. (2017) (68)
- Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations (2014) (65)
- Suramin Derivatives as Inhibitors and Activators of Protein-tyrosine Phosphatases* (2004) (64)
- Assessment of Protein-tyrosine Phosphatase 1B Substrate Specificity Using “Inverse Alanine Scanning”* (2000) (64)
- Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. (2013) (63)
- Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. (2009) (62)
- Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2* (1999) (62)
- Negative Regulation of Stat3 by Activating PTPN11 Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia* (2009) (58)
- Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry* (2006) (58)
- Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation (2019) (55)
- The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop* (2002) (55)
- Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. (2014) (55)
- Thermodynamic Study of Ligand Binding to Protein-tyrosine Phosphatase 1B and Its Substrate-trapping Mutants* (2000) (54)
- Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction (1998) (54)
- Crystal Structure of the Yersinia Protein-tyrosine Phosphatase YopH Complexed with a Specific Small Molecule Inhibitor* (2003) (54)
- Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. (2012) (52)
- Comparative Mechanistic and Substrate Specificity Study of Inositol Polyphosphate 5-Phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2* (2004) (51)
- EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. (2016) (50)
- Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. (2011) (50)
- PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours (2019) (50)
- Potent Low Molecular Weight Substrates for Protein-tyrosine Phosphatase (1996) (49)
- A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes. (2012) (48)
- Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. (2016) (48)
- Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling* (2014) (47)
- PRL2/PTP4A2 Phosphatase Is Important for Hematopoietic Stem Cell Self‐Renewal (2014) (47)
- The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo (2012) (47)
- Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation* (2013) (47)
- Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein*♦ (2012) (45)
- Functional studies of protein tyrosine phosphatases with chemical approaches. (2005) (44)
- Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. (2006) (43)
- A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. (2013) (42)
- The Catalytic Mechanism of Cdc25A Phosphatase* (2002) (42)
- PRL-1 Protein Promotes ERK1/2 and RhoA Protein Activation through a Non-canonical Interaction with the Src Homology 3 Domain of p115 Rho GTPase-activating Protein* (2011) (41)
- Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies (2012) (40)
- SHP2 is a target of the immunosuppressant tautomycetin. (2011) (39)
- SHP2 phosphatase as a novel therapeutic target for melanoma treatment (2016) (39)
- Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase* (2008) (38)
- Phosphatase of regenerating liver: a novel target for cancer therapy (2014) (38)
- Proteomic approaches to studying protein tyrosine phosphatases. (2007) (37)
- Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis. (2002) (37)
- Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. (2015) (36)
- Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. (2016) (36)
- Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma. (2013) (36)
- Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical. (2013) (35)
- Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase. (2016) (35)
- Covalent inhibition of protein tyrosine phosphatases. (2017) (34)
- Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. (2017) (33)
- PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis (2017) (33)
- Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase. (2007) (33)
- Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction* (2013) (33)
- Phosphatase of Regenerating Liver 2 (PRL2) Deficiency Impairs Kit Signaling and Spermatogenesis* (2013) (32)
- Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors. (2012) (32)
- Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis. (2004) (31)
- Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers (2017) (31)
- Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. (2014) (31)
- Erratum: Structural and functional analysis of the costimulatory receptor programmed death-1 (Immunity (March 2004) 20 (337-347)) (2004) (31)
- Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1 (*) (1996) (30)
- Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. (2008) (29)
- Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction (2014) (29)
- Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen. (2016) (29)
- Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis (2010) (28)
- SENP1 regulates IFN-&ggr;−STAT1 signaling through STAT3−SOCS3 negative feedback loop (2017) (27)
- Molecular Determinants of Substrate Recognition in Hematopoietic Protein-tyrosine Phosphatase* (2004) (27)
- Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate* (2011) (26)
- Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc14* (2004) (26)
- Is the PTPase-vanadate complex a true transition state analogue? (2002) (26)
- Small molecule approach to studying protein tyrosine phosphatase. (2005) (26)
- Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor (2017) (26)
- Global analysis of protein tyrosine phosphatase activity with ultra-sensitive fluorescent probes. (2006) (25)
- High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45 (2012) (24)
- Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. (2010) (24)
- SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice (2012) (24)
- Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development. (2011) (23)
- Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration. (2003) (23)
- Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia (2016) (23)
- Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors. (2013) (22)
- Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases. (2017) (22)
- The Active Site Specificity of the Yersinia Protein-tyrosine Phosphatase (*) (1996) (21)
- A Facile Hydroxyindole Carboxylic Acid Based Focused Library Approach for Potent and Selective Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B (2013) (21)
- IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity. (2013) (21)
- Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor. (2005) (20)
- Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins. (2018) (20)
- Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase. (2003) (20)
- Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice (2014) (20)
- Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids. (2018) (20)
- Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin (1995) (17)
- Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis. (2015) (17)
- Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. (2005) (17)
- Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis (2016) (16)
- Probing the phosphopeptide specificities of protein tyrosine phosphatases, SH2 and PTB domains with combinatorial library methods. (2002) (16)
- Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor (2010) (16)
- Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases. (2011) (16)
- Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis. (2013) (16)
- Systemic inhibition of PTPN22 augments anticancer immunity. (2021) (15)
- Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate. (2004) (15)
- Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism. (2016) (15)
- SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer (2020) (15)
- Development and Validation of a High-Throughput Cell-Based Screen To Identify Activators of a Bacterial Two-Component Signal Transduction System (2015) (15)
- Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening. (2011) (15)
- Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies (2014) (14)
- A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity. (2002) (14)
- Development and Characterization of an Endotoxemia Model in Zebra Fish (2018) (14)
- Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis (2020) (13)
- Highly Potent and Selective N-aryl Oxamic Acid Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (mPTPB). (2020) (13)
- Assays for protein-tyrosine phosphatases. (2002) (13)
- Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice (2014) (13)
- Integrated Analysis of Global mRNA and Protein Expression Data in HEK293 Cells Overexpressing PRL-1 (2013) (12)
- Application of hydrogen/deuterium exchange mass spectrometry to study protein tyrosine phosphatase dynamics, ligand binding, and substrate specificity. (2007) (12)
- Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. (2012) (12)
- Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis (2020) (12)
- Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors (2017) (12)
- Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation (2016) (12)
- The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors (2021) (12)
- A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. (2015) (11)
- First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors. (2019) (11)
- Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin (2019) (11)
- Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals (2015) (10)
- EGFL 6 regulates the asymmetric division , maintenance and metastasis of ALDH + ovarian cancer cells (2016) (9)
- An affinity-based fluorescence polarization assay for protein tyrosine phosphatases. (2007) (9)
- Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation (2021) (7)
- Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta. (2014) (7)
- Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 (2020) (7)
- Activity-based protein profiling of protein tyrosine phosphatases. (2009) (6)
- Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. (2016) (6)
- Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis. (2014) (6)
- Long non‐coding RNA SCARNA2 induces cutaneous squamous cell carcinoma progression via modulating miR‐342‐3p expression (2020) (6)
- A continuous spectrophotometric assay for mitogen-activated protein kinase kinases. (2012) (5)
- The tumor promoter‐activated protein kinase Cs are a system for regulating filopodia (2017) (5)
- Cutting Edge Cutting Edge : The PTPN 22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling 1 (2009) (5)
- Current status of PTP-based therapeutics (2016) (4)
- A modified cysteinyl-labeling assay reveals reversible oxidation of classical and dual specificity phosphatases in angiomyolipoma cells (2008) (4)
- A Highly Selective and Potent PTP-MEG 2 Inhibitor with Therapeutic Potential for Type 2 Diabetes (2012) (4)
- Functional interrogation and therapeutic targeting of protein tyrosine phosphatases. (2021) (3)
- CHAPTER 112 – Inhibitors of Protein Tyrosine Phosphatases (2003) (3)
- The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors (2022) (3)
- The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis (2018) (3)
- Emerging new techniques for studying protein phosphatases. (2007) (3)
- High-throughput screening strategies for space-based radiation countermeasure discovery. (2022) (3)
- Elevated Expression of MAPK Phosphatase 3 in Breast Tumors—A Mechanism of Tamoxifen Resistance (2006) (2)
- Measuring protein phosphatase activity with physiological substrates. (2003) (2)
- Combinatorial chemistry and peptide library methods to characterize protein phosphatases. (2003) (2)
- An Integrated Proteomic Strategy to Identify SHP2 Substrates. (2022) (2)
- PTP‐MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates (2021) (2)
- Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc 14 (2004) (2)
- Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions (2022) (2)
- A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis. (2014) (2)
- Tyrosine phosphatases in cancer: Targets for therapeutic intervention (2004) (1)
- A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors. (2012) (1)
- Faculty Opinions recommendation of Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. (2011) (1)
- PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates (2019) (1)
- PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy (2022) (1)
- Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 (2003) (1)
- Enantioselective Synthesis of (S)‐3‐Carboxy‐4‐((carboxy)difluoromethyl)phenylalanine in Protected Form and Its Incorporation into a PTP‐1B‐Directed Tripeptide (2004) (1)
- Cellular Immunology and Immune Regulation (2008) (1)
- Activity‐Based Probes for Profiling Protein Activities (2019) (1)
- PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. (2022) (1)
- The Catalytic Mechanism of Cdc 25 A Phosphatase † (2002) (1)
- Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells (2022) (1)
- Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. (2021) (1)
- Enantioselective Synthesis of Nonphosphorus‐Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides. (1998) (1)
- Crystal Structure PTP1B complex with aryl Seleninic acid (2008) (0)
- prl-1 c104s mutant in complex with sulfate (2005) (0)
- The crystal structure of L-threonine-O-3-phosphate decarboxylase from Porphyromonas gingivalis (2009) (0)
- The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells. (2012) (0)
- Faculty Opinions recommendation of Allosteric inhibition of protein tyrosine phosphatase 1B. (2004) (0)
- Faculty Opinions recommendation of Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. (2010) (0)
- TCPTP-deficiency in muscle does not alter insulin signalling and glucose homeostasis. (2012) (0)
- Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. (2009) (0)
- Phosphorylation Pyruvate Kinase M2 Tyrosine Protein Tyrosine Phosphatase 1B Regulates (2013) (0)
- Potent and selective protein tyrosine phosphatase inhibitors (2002) (0)
- KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML (2011) (0)
- Abstract 3398: PTPN22 is a systemic target for augmenting antitumor immunity (2020) (0)
- Discovery and Evaluation of PRL Trimer Disruptors for Novel Anticancer Agents. (2016) (0)
- Astabiotics: Antimicrobial Signal Transduction Activators (2013) (0)
- Faculty Opinions recommendation of Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. (2003) (0)
- A novel fluorogenic reporter substrate for 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's Disease. (2023) (0)
- 833 - Tyrosyl Phosphorylation of Kras Disrupts the Gtpase Cycle and Inhibits Pancreatic Cancer Cell Growth (2018) (0)
- CB&DD Senior Editor Team (2009) (0)
- olecular-Weight S-Nitrosothiols and S-Nitrosylated uman Serum Albumin (2000) (0)
- Crystal structure of human protein tyrosine phosphatase 4A1 (2004) (0)
- Microsoft Word-PTP1B/nM/Rev (2001) (0)
- of SHP2 as a druggable target in diseases involving oncogenic KIT Role of SHP2 phosphatase in KIT-induced transformation: identification (2013) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES (1998) (0)
- Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. (2022) (0)
- Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer (2022) (0)
- Abstract B13: Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein (2016) (0)
- Faculty Opinions recommendation of Reprogramming control of an allosteric signaling switch through modular recombination. (2003) (0)
- PRL2 Phosphatase Is a Key Mediator of Oncogenic Cytokine Signaling in Leukemia Stem Cells (2016) (0)
- Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation (2019) (0)
- Crystal structure of an uncharacterized sugar kinase PH1459 from Pyrococcus horikoshii in complex with AMP-PNP (2009) (0)
- Abstract A66: The tissue transglutaminase 2–fibronectin protein complex: A new target in ovarian cancer (2018) (0)
- Faculty Opinions recommendation of A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (2006) (0)
- phosphoproteome to drive pro-metastatic signal transduction (2013) (0)
- Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor (2010) (0)
- Abstract 20959: Inhibition of Shp2 Ameliorates Systemic Lupus Erythematosus-Associated Cardiac Pathogenesis (2017) (0)
- Substrate specificity of the protein tyrosine phosphatases ( enzyme kinetics ) (2005) (0)
- CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1 (2004) (0)
- PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis (2017) (0)
- The Effect on the Function of the Generalacid Catalyst from Mutations of the Invariant Tryptophan and Arginine Residues in the Protein-Tyrosine Phosphatase from Yersinia (1999) (0)
- Faculty Opinions recommendation of Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. (2010) (0)
- Faculty Opinions recommendation of Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. (2004) (0)
- native structure prl-1 (ptp4a1) (2005) (0)
- Crystal structure of sugar ABC transporter (sugar-binding protein) from Bacillus halodurans (2009) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G (2001) (0)
- Structure-based design of small molecule protein-tyrosine phosphatase inhibitors (2002) (0)
- Yersinia Protein-Tyrosine Phosphatase complexed with pNCS (Yop51,Pasteurella X,Ptpase,Yop51delta162) (Catalytic Domain, Residues 163-468) Mutant With Cys 235 Replaced By Arg (C235r) (2003) (0)
- CB&DD Senior Editor Team (2008) (0)
- The Role of the Active SiteArginine in a Protein-Tyrosine Phosphatase. Does Positive Charge Cause a Change in Mechanismfor Enzymatic Phosphoryl Transfer? (1999) (0)
- Crystal structure of Prephenate dehydrogenase from Streptococcus thermophilus (2008) (0)
- A Target Enablement Package for the Inhibition of SHIP1 as a Therapeutic Strategy for the Treatment of Alzheimer’s Disease (2022) (0)
- promotes TGFβ signaling and fibrosis in systemic sclerosis. (2017) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES (1998) (0)
- Abstract 1959: Therapeutic rationale for SHP2 phosphatase inhibitors: Targeting drug-resistant breast cancer via blockade of FGFR1 signaling (2018) (0)
- Inhibiteurs et ligands de ptp1b (2002) (0)
- PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours (2019) (0)
- The crystal structure of an amidohydrolase from Mycoplasma synoviae with Zn ion bound (2010) (0)
- Crystal structure of ABC transporter, substrate binding protein Aeropyrum pernix (2008) (0)
- PRL2 Phosphatase Regulate Early Stage T-Cell Development through Fine-Tuning SCF/Kit Signaling (2014) (0)
- PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. (2022) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 (2001) (0)
- Kinetic Isotope Effects on Reactions of Tyrosine Phosphatases (1995) (0)
- CB&DD Senior Editor Team (2010) (0)
- Access provided by IUPUI University Library, Indiana (Ruth Lilly) Altmetric: 0Citations: 2More detail Letter to the Editor Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia (2017) (0)
- Cell Signaling Associated with Autoimmunity Impairs B Cutting Edge: The PTPN22 Allelic Variant (2009) (0)
- Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription. (2021) (0)
- A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation (2016) (0)
- Crystal structure of Methyltransferase from Pyrococcus furiosus (2008) (0)
- Crystal structure of a fatty acid amp ligase from e. coli with an acyl adenylate product bound (2009) (0)
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