Zigang Dong
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Zigang Dongengineering Degrees
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Engineering Computer Science
Zigang Dong's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Zigang Dong's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Post-translational modification of p53 in tumorigenesis (2004) (1271)
- Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. (1994) (398)
- Molecular targets of phytochemicals for cancer prevention (2011) (394)
- ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation* (2000) (377)
- Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. (2006) (336)
- p38 Kinase Mediates UV-induced Phosphorylation of p53 Protein at Serine 389* (1999) (302)
- Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction (2003) (291)
- Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. (1999) (277)
- The functional contrariety of JNK (2007) (272)
- Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases* (2003) (266)
- (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. (2006) (247)
- The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. (2002) (245)
- Molecular mechanism of the chemopreventive effect of resveratrol. (2003) (231)
- Lessons from the past (2005) (231)
- [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. (2009) (231)
- Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer (2016) (229)
- The two faces of capsaicin. (2011) (220)
- AKT as a Therapeutic Target for Cancer. (2019) (201)
- Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. (2008) (190)
- Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. (2008) (182)
- Resveratrol directly targets COX‐2 to inhibit carcinogenesis (2008) (180)
- The enigmatic effects of caffeine in cell cycle and cancer. (2007) (177)
- Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. (2002) (174)
- Inhibition of Activator Protein 1 Activity and Neoplastic Transformation by Aspirin* (1997) (172)
- Requirement of Erk, but Not JNK, for Arsenite-induced Cell Transformation* (1999) (169)
- Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. (2005) (168)
- Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. (1996) (167)
- Mechanisms of inhibition of the Ras‐MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (‐)‐epigallocatechin‐3‐gallate and theaflavin‐3,3′‐digallate1 (2001) (164)
- Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis* (2001) (154)
- ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4 (2012) (148)
- Cancer prevention research — then and now (2009) (148)
- Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. (2003) (145)
- Myricetin suppresses UVB-induced skin cancer by targeting Fyn. (2008) (144)
- Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats. (1988) (144)
- Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy (2021) (141)
- The Intermediate Filament Protein Vimentin Is a New Target for Epigallocatechin Gallate* (2005) (140)
- Translocation of Protein Kinase Cε and Protein Kinase Cδ to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis* (1999) (138)
- Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells (2008) (134)
- Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells (2010) (133)
- Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. (2007) (129)
- Transforming Cancer Prevention through Precision Medicine and Immune-oncology (2016) (128)
- Signal transduction pathways: targets for green and black tea polyphenols. (2003) (127)
- Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation (1998) (126)
- A dominant negative mutant of jun blocking 12‐O‐tetradecanoylphorbol‐13‐acetate–induced invasion in mouse keratinocytes (1997) (122)
- Phosphatidylinositol-3 Kinase Is Necessary for 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Transformation and Activated Protein 1 Activation* (1997) (121)
- Ultraviolet B-induced Activated Protein-1 Activation Does Not Require Epidermal Growth Factor Receptor but Is Blocked by a Dominant Negative PKCλ/ι* (1996) (120)
- Antioxidant properties of aspirin: Characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-κB activation, and TNF-α production (2004) (119)
- The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications (2016) (118)
- The molecular mechanisms of arsenic-induced cell transformation and apoptosis. (2002) (117)
- Direct Inhibition of Insulin-Like Growth Factor-I Receptor Kinase Activity by (−)−Epigallocatechin-3-Gallate Regulates Cell Transformation (2007) (117)
- Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. (2004) (116)
- Direct Evidence for an Important Role of Sphingomyelinase in Ultraviolet-induced Activation of c-Jun N-Terminal Kinase* (1997) (115)
- Regulation of microRNAs by epigenetics and their interplay involved in cancer (2013) (113)
- Human αA- and αB-crystallins prevent UVA-induced apoptosis through regulation of PKCα, RAF/MEK/ERK and AKT signaling pathways (2004) (110)
- Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. (2007) (110)
- Inhibition of Ultraviolet B–Induced AP‐1 Activation by Theaflavins From Black Tea (2000) (108)
- Epigallocatechin 3-Gallate and Green Tea Catechins: United They Work, Divided They Fail (2009) (108)
- Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK. (2011) (107)
- Involvement of c‐jun NH2‐terminal kinases in resveratrol‐induced activation of p53 and apoptosis (2002) (106)
- Signal Transduction Pathways Involved in Phosphorylation and Activation of p70S6K Following Exposure to UVA Irradiation* (2001) (105)
- Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. (2007) (103)
- Inhibitory Mechanisms of Tea Polyphenols on the Ultraviolet B-activated Phosphatidylinositol 3-Kinase-dependent Pathway* (2001) (103)
- USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer (2013) (102)
- Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1 (2011) (101)
- (-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase* (2008) (101)
- Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity. (2010) (100)
- JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-α but Not by 12-O-Tetradecanoylphorbol-13-Acetate* (1999) (100)
- Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr (VI)-induced DNA damage and Cr (IV)- or TPA-stimulated NF-κB activation (2000) (100)
- Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity (2012) (99)
- Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. (2010) (98)
- The Amazing and Mighty Ginger (2011) (98)
- TRAF4 is a critical molecule for Akt activation in lung cancer. (2013) (97)
- ERKs and p38 Kinases Mediate Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10* (2000) (97)
- Freshly Fractured Crystalline Silica Induces Activator Protein-1 Activation through ERKs and p38 MAPK* (1999) (94)
- Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. (2009) (94)
- Epigallocatechin Gallate Suppresses Lung Cancer Cell Growth through Ras–GTPase-Activating Protein SH3 Domain-Binding Protein 1 (2010) (94)
- Activation of JNK1, RSK2, and MSK1 Is Involved in Serine 112 Phosphorylation of Bad by Ultraviolet B Radiation* (2002) (94)
- Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation. (2005) (93)
- Fyn is a novel target of (−)‐epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation (2008) (93)
- Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf. (2010) (92)
- Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase. (2010) (91)
- Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. (2010) (90)
- Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells. (2000) (90)
- UVA Induces Ser381 Phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK Pathways* (2001) (89)
- Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. (2009) (89)
- The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. (2008) (88)
- Requirement of ATM in UVA-induced Signaling and Apoptosis* (2002) (86)
- Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 28 Is Mediated by MSK1* (2001) (86)
- Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors. (1995) (85)
- Phosphorylation of 4E-BP1 Is Mediated by the p38/MSK1 Pathway in Response to UVB Irradiation* (2002) (84)
- Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. (2008) (83)
- Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester (2001) (83)
- Circulating Tumor Cells: Moving Biological Insights into Detection (2017) (83)
- Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. (2012) (83)
- Inducible Covalent Posttranslational Modification of Histone H3 (2005) (81)
- Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2 (2014) (81)
- Precision medicine: the foundation of future cancer therapeutics (2017) (80)
- Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K (2011) (80)
- Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging (2017) (79)
- Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wild Type and L858R/T790M Mutant EGFR* (2014) (78)
- The tumor suppressor p16INK4a prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity (2005) (78)
- ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal. (2014) (77)
- Cocoa Procyanidins Suppress Transformation by Inhibiting Mitogen-activated Protein Kinase Kinase* (2008) (76)
- Toxic Phytochemicals and Their Potential Risks for Human Cancer (2014) (76)
- PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer. (1999) (75)
- Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. (2004) (75)
- Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20 (2002) (75)
- The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells (1999) (74)
- Effects of food factors on signal transduction pathways. (2000) (73)
- Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines* (2011) (73)
- RSK2 Mediates Muscle Cell Differentiation through Regulation of NFAT3* (2007) (72)
- T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity* (2010) (71)
- Signal transduction pathways in cancer development and as targets for cancer prevention. (2005) (70)
- Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells. (2008) (70)
- MST1 Promotes Apoptosis through Phosphorylation of Histone H2AX* (2010) (70)
- 7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses Ultraviolet B-induced Skin Cancer by Targeting Cot and MKK4* (2011) (69)
- Lymphokine-Activated Killer T-Cell-Originated Protein Kinase Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells (2006) (69)
- The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-κB (1999) (69)
- The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction. (2005) (68)
- [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. (2014) (68)
- Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production (2014) (68)
- Equol, a Metabolite of the Soybean Isoflavone Daidzein, Inhibits Neoplastic Cell Transformation by Targeting the MEK/ERK/p90RSK/Activator Protein-1 Pathway* (2007) (66)
- Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation (2016) (66)
- MAP Kinases Mediate UVB-induced Phosphorylation of Histone H3 at Serine 28* (2001) (66)
- Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K (2012) (65)
- A regulatory mechanism for RSK2 NH(2)-terminal kinase activity. (2009) (64)
- Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species. (2008) (62)
- Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines (2011) (62)
- Src kinase is a direct target of apigenin against UVB-induced skin inflammation. (2013) (62)
- Progressive elevation of ap-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse jb6 cell variants. (1995) (62)
- CRISPR/Cas9 – An evolving biological tool kit for cancer biology and oncology (2019) (61)
- Arsenite-induced Phosphorylation of Histone H3 at Serine 10 Is Mediated by Akt1, Extracellular Signal-regulated Kinase 2, and p90 Ribosomal S6 Kinase 2 but Not Mitogen- and Stress-activated Protein Kinase 1* (2003) (61)
- Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. (2011) (61)
- Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. (2010) (61)
- Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation (2014) (61)
- The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus). (2010) (60)
- Inhibition of cell transformation by resveratrol and its derivatives: differential effects and mechanisms involved (2003) (59)
- (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells. (2013) (59)
- Cancer prevention and control: alarming challenges in China. (2016) (59)
- Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3* (2003) (59)
- Involvement of Nuclear Factor of Activated T Cells Activation in UV Response (2000) (58)
- Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development. (1996) (58)
- Regulation of N-nitrosodimethylamine demethylase in rat liver and kidney. (1987) (58)
- EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma (2015) (58)
- Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathway. (2013) (57)
- Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin (2013) (56)
- Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K (2013) (55)
- Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer. (2011) (55)
- Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (2008) (55)
- T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. (2007) (54)
- Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability (2013) (54)
- p38 MAP kinase plays a functional role in UVB‐Induced mouse skin carcinogenesis (2011) (54)
- Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. (2012) (53)
- miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma (2015) (53)
- Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth (2013) (53)
- The epithelial–mesenchymal transition (EMT) is regulated by oncoviruses in cancer (2016) (53)
- Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo (2018) (52)
- Dosage‐dependent dominance over wild‐type p53 of a mutant p53 isolated from nasopharyngeal carcinoma 1 (1993) (52)
- Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-induced Neoplastic Cell Transformation* (2010) (52)
- Delphinidin Attenuates Neoplastic Transformation in JB6 Cl41 Mouse Epidermal Cells by Blocking Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling (2008) (51)
- Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A (2003) (50)
- Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. (2012) (50)
- No point mutation of ha‐ras or p53 genes expressed in preneoplastic‐to‐neoplastic progression as modeled in mouse JB6 cell variants (1993) (50)
- Regulation of Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10 by Fyn Kinase* (2005) (50)
- Asbestos induces activator protein-1 transactivation in transgenic mice. (1999) (50)
- Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53 (2012) (49)
- Involvement of the Akt/mTOR pathway on EGF‐induced cell transformation (2003) (49)
- Autophagy and Cellular Senescence Mediated by Sox2 Suppress Malignancy of Cancer Cells (2013) (48)
- TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. (2011) (48)
- Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. (2009) (48)
- Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. (2008) (48)
- 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. (2011) (48)
- AP-1/Jun Is Required for Early Xenopus Development and Mediates Mesoderm Induction by Fibroblast Growth Factor but Not by Activin (*) (1996) (47)
- The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation. (2009) (47)
- Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis. (2002) (47)
- The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. (2004) (47)
- A Novel Role for Mixed-Lineage Kinase-Like Mitogen-Activated Protein Triple Kinase α in Neoplastic Cell Transformation and Tumor Development (2004) (47)
- Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-kappaB activation, and TNF-alpha production. (1999) (46)
- Harvesting Cells Under Anchorage-Independent Cell Transformation Conditions for Biochemical Analyses (2002) (46)
- Resveratrol induces apoptosis by directly targeting Ras-GTPase activating protein SH3 domain binding protein 1 (G3BP1) (2014) (46)
- Evaluation of Cancer-Preventive Activity and Structure–Activity Relationships of 3-Demethylubiquinone Q2, Isolated from the Ascidian Aplidium glabrum, and its Synthetic Analogs (2006) (45)
- RSK2 mediates NF‐κB activity through the phosphorylation of IκBα in the TNF‐R1 pathway (2010) (45)
- Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-κB Activity in Triple-Negative Breast Cancer Cells (2019) (45)
- Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells. (2002) (45)
- The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation (2006) (44)
- Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2 (2008) (44)
- Phosphorylation of Caspase-8 (Thr-263) by Ribosomal S6 Kinase 2 (RSK2) Mediates Caspase-8 Ubiquitination and Stability* (2010) (44)
- Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. (2004) (44)
- Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer (2014) (44)
- Phorbol Ester-induced Expression of Airway Squamous Cell Differentiation Marker, SPRR1B, Is Regulated by Protein Kinase Cδ/Ras/MEKK1/MKK1-dependent/AP-1 Signal Transduction Pathway* (2000) (43)
- Molecular and cellular targets (2006) (43)
- T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of MKP1 Protein Prevents Solar Ultraviolet Light-induced Inflammation through Inhibition of the p38 Protein Signaling Pathway* (2011) (42)
- Identification of novel phosphoproteins in signaling pathways triggered by latent membrane protein 1 using functional proteomics technology (2006) (42)
- Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. (2010) (42)
- Tyrosylprotein Sulfotransferase-1 and Tyrosine Sulfation of Chemokine Receptor 4 Are Induced by Epstein-Barr Virus Encoded Latent Membrane Protein 1 and Associated with the Metastatic Potential of Human Nasopharyngeal Carcinoma (2013) (42)
- Prediction of Molecular Targets of Cancer Preventing Flavonoid Compounds Using Computational Methods (2012) (41)
- Involvement of Erks activation in cadmium‐induced AP‐1 transactivation in vitro and in vivo (2001) (41)
- UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28 (2012) (41)
- Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis. (2007) (40)
- A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo (2017) (40)
- Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization. (2016) (40)
- Recent advances in precision oncology research (2018) (40)
- Cancer-related circular RNA: diverse biological functions (2021) (40)
- Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib‐resistant lung cancer growth (2015) (40)
- 7,3′,4′-Trihydroxyisoflavone Inhibits Epidermal Growth Factor-induced Proliferation and Transformation of JB6 P+ Mouse Epidermal Cells by Suppressing Cyclin-dependent Kinases and Phosphatidylinositol 3-Kinase* (2010) (39)
- Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR‐mediated VEGF production (2017) (39)
- A Phase 2a Study of Topical Perillyl Alcohol Cream for Chemoprevention of Skin Cancer (2010) (39)
- Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging. (2015) (39)
- P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. (2011) (39)
- p85α Acts as a Novel Signal Transducer for Mediation of Cellular Apoptotic Response to UV Radiation (2007) (39)
- Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells (1997) (39)
- Epstein–Barr virus latent membrane protein 1 mediates serine 25 phosphorylation and nuclear entry of annexin A2 via PI‐PLC–PKCα/PKCβ pathway (2008) (38)
- RSK2 as a key regulator in human skin cancer. (2012) (38)
- Quercetin‐3‐methyl ether inhibits lapatinib‐sensitive and ‐resistant breast cancer cell growth by inducing G2/M arrest and apoptosis (2013) (38)
- The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis (2017) (38)
- Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells* (2010) (37)
- 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. (2014) (37)
- Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression (2015) (37)
- Cyclin dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway (2015) (37)
- Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo (2019) (36)
- Polycomb (PcG) Proteins, BMI1 and SUZ12, Regulate Arsenic-induced Cell Transformation* (2012) (36)
- Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model (2021) (36)
- EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma. (2012) (36)
- Aberrant Methylation of Different DNA Repair Genes Demonstrates Distinct Prognostic Value for Esophageal Cancer (2011) (35)
- Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation* (2011) (34)
- Cot, a novel kinase of histone H3, induces cellular transformation through up‐regulation of c‐fos transcriptional activity (2008) (34)
- Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft. (2015) (34)
- A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases* (2013) (34)
- 20‐O‐β‐d‐Glucopyranosyl‐20(S)‐Protopanaxadiol Suppresses UV‐Induced MMP‐1 Expression Through AMPK‐Mediated mTOR Inhibition as a Downstream of the PKA‐LKB1 Pathway (2014) (34)
- Licochalcone A, a Natural Inhibitor of c-Jun N-Terminal Kinase 1 (2013) (34)
- Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma (2012) (34)
- Theaflavin‐3, 3′‐digallate induces epidermal growth factor receptor downregulation (2006) (33)
- Inhibition of epidermal growth factor‐induced cell transformation and Akt activation by caffeine (2005) (33)
- Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis (2014) (33)
- CDK12 and PAK2 as novel therapeutic targets for human gastric cancer (2020) (32)
- Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma (2013) (31)
- Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin (2015) (31)
- Chemopreventive Effects of Licorice and Its Components (2015) (31)
- TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis. (2018) (31)
- Pifithrin‐α promotes p53‐mediated apoptosis in JB6 cells (2003) (31)
- Heterogeneity of aberrant immunoglobulin expression in cancer cells (2011) (31)
- Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. (2013) (31)
- Resatorvid‐based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV‐induced NF‐κB and AP‐1 Signaling in Keratinocytes and Mouse Skin (2016) (31)
- 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx. (2013) (30)
- Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers. (2000) (30)
- Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway. (2007) (30)
- Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. (2012) (30)
- Addressing the challenges of applying precision oncology (2017) (30)
- Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. (2017) (30)
- Signal transduction and molecular targets of selected flavonoids. (2013) (29)
- The role of necroptosis, an alternative form of cell death, in cancer therapy (2013) (29)
- The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation (2014) (29)
- Cancer Prevention Research in China (2015) (29)
- c-Jun N-Terminal Kinase 1 Phosphorylates Myt1 To Prevent UVA-Induced Skin Cancer (2009) (29)
- Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. (2016) (28)
- Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions. (1994) (28)
- Cross‐validation of Murine UV Signal Transduction Pathways in Human Skin † (2008) (28)
- A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer. (2015) (28)
- Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. (2011) (28)
- Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase (2016) (28)
- Naringenin targets ERK2 and suppresses UVB‐induced photoaging (2016) (28)
- Quercetin Potentiates UVB-Induced c-Fos Expression: Implications for Its Use as a Chemopreventive Agent (2010) (28)
- The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis* (2012) (27)
- N,N′-Dinitrosopiperazine-mediated Ezrin Protein Phosphorylation via Activation of Rho Kinase and Protein Kinase C Is Involved in Metastasis of Nasopharyngeal Carcinoma 6-10B Cells* (2011) (27)
- Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells , (2006) (27)
- Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation. (2014) (27)
- Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer. (2021) (27)
- CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. (2019) (27)
- The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. (2014) (27)
- Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization (2018) (27)
- Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor (2017) (27)
- Structural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2 (2009) (26)
- The resveratrol analogue 3,5,3′,4′,5′‐pentahydroxy‐trans‐stilbene inhibits cell transformation via MEK (2008) (26)
- Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice (2018) (26)
- Marine Alkaloid Polycarpine and Its Synthetic Derivative Dimethylpolycarpine Induce Apoptosis in JB6 Cells Through p53- and Caspase 3-Dependent Pathways (2004) (26)
- CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. (2013) (26)
- NS-398 and Piroxicam Suppress UVB-induced Activator Protein 1 Activity by Mechanisms Independent of Cyclooxygenase-2* (2003) (26)
- Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. (2013) (26)
- Precision oncology- the future of personalized cancer medicine? (2017) (25)
- Cancer prevention by food factors through targeting signal transduction pathways. (2004) (25)
- Stabilization of Quercetin Paradoxically Reduces Its Proapoptotic Effect on UVB-Irradiated Human Keratinocytes (2008) (25)
- Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction (2013) (25)
- 5-Deoxykaempferol Plays a Potential Therapeutic Role by Targeting Multiple Signaling Pathways in Skin Cancer (2010) (25)
- Discovery of Novel Checkpoint Kinase 1 Inhibitors by Virtual Screening Based on Multiple Crystal Structures (2011) (25)
- Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3‐kinase‐mediated Akt signaling (2015) (25)
- Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering (2014) (25)
- 2-Arachidonoylglycerol Stimulates Activator Protein-1-dependent Transcriptional Activity and Enhances Epidermal Growth Factor-induced Cell Transformation in JB6 P+ Cells* (2005) (25)
- Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer. (2019) (25)
- (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth In Vitro and In Vivo (2011) (24)
- Ginsenosides and their metabolites: a review of their pharmacological activities in the skin (2015) (24)
- Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance (2014) (24)
- Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)). (2007) (24)
- ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK (2017) (24)
- Targeting PRPK and TOPK for skin cancer prevention and therapy (2018) (24)
- Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis (2015) (24)
- Embryonic stem‐cell‐preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells (2011) (24)
- Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis (2016) (24)
- A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells (2014) (23)
- Phosphorylation of Ser28 in Histone H3 Mediated by Mixed Lineage Kinase-like Mitogen-activated Protein Triple Kinase α* (2005) (23)
- The Daidzein Metabolite, 6,7,4'-Trihydroxyisoflavone, Is a Novel Inhibitor of PKCα in Suppressing Solar UV-Induced Matrix Metalloproteinase 1 (2014) (23)
- Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis (2015) (23)
- Desmethylubiquinone Q2 from the Far-Eastern ascidian Aplidium glabrum: structure and synthesis (2005) (23)
- p38 Mitogen-activated Protein Kinase Regulation of JB6 Cl41 Cell Transformation Promoted by Epidermal Growth Factor* (2003) (23)
- A Derivative of Chrysin Suppresses Two-Stage Skin Carcinogenesis by Inhibiting Mitogen- and Stress-Activated Kinase 1 (2013) (23)
- Requirement of T-lymphokine-activated killer cell-originated protein kinase for TRAIL resistance of human HeLa cervical cancer cells. (2010) (23)
- Inhibition of LTA4H by bestatin in human and mouse colorectal cancer (2019) (23)
- Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. (2017) (23)
- Glycolytic genes in cancer cells are more than glucose metabolic regulators (2014) (23)
- Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma (2013) (22)
- The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression (2016) (22)
- Dietary Modulation of Cell Signaling Pathways (2008) (22)
- Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC (2017) (22)
- A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer (2016) (22)
- Therapies based on targeting Epstein‐Barr virus lytic replication for EBV‐associated malignancies (2018) (22)
- Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells. (2004) (21)
- COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation. (2006) (21)
- JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity. (2014) (21)
- Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma (2019) (20)
- Breaking the NF-κB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis (2010) (20)
- Inhibiting breast cancer by targeting the thromboxane A2 pathway (2017) (20)
- Proapoptotic and Anticarcinogenic Activities of Leviusculoside G from the Starfish Henricia leviuscula and Probable Molecular Mechanism (2008) (19)
- Benzyl Isothiocyanate Inhibits Prostate Cancer Development in the Transgenic Adenocarcinoma Mouse Prostate (TRAMP) Model, Which Is Associated with the Induction of Cell Cycle G1 Arrest (2016) (19)
- Clusterin induced by N,N′-Dinitrosopiperazine is involved in nasopharyngeal carcinoma metastasis (2015) (19)
- SDCBP/MDA-9/syntenin phosphorylation by AURKA promotes esophageal squamous cell carcinoma progression through the EGFR-PI3K-Akt signaling pathway (2020) (19)
- 3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2. (2019) (19)
- Oligomycin A enhances apoptotic effect of TRAIL through CHOP‐mediated death receptor 5 expression (2013) (19)
- Dialogue between ERKs and JNKs: friendly or antagonistic? (2003) (18)
- Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery (2020) (18)
- 3,6,2′,4′,5′-Pentahydroxyflavone, an Orally Bioavailable Multiple Protein Kinase Inhibitor, Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer* (2014) (18)
- Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. (2003) (18)
- Effects of MAP kinase inhibitors on epidermal growth factor‐induced neoplastic transformation of human keratinocytes (2006) (18)
- Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft. (2015) (18)
- Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. (2019) (18)
- Discovery of the Novel mTOR Inhibitor and Its Antitumor Activities In Vitro and In Vivo (2013) (18)
- The Role of p21-Activated Kinases in Cancer and Beyond: Where Are We Heading? (2021) (18)
- Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. (2016) (18)
- Increased synthesis of phosphocholine is required for UV-induced AP-1 activation (1998) (18)
- Tumor Necrosis Factor Receptor-associated Factor Family Protein 2 Is a Key Mediator of the Epidermal Growth Factor-induced Ribosomal S6 Kinase 2/cAMP-responsive Element-binding Protein/Fos Protein Signaling Pathway* (2012) (17)
- Anti‐arthritis effects of (E)‐2,4‐bis(p‐hydroxyphenyl)‐2‐butenal are mediated by inhibition of the STAT3 pathway (2014) (17)
- MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance (2018) (17)
- Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. (2007) (17)
- Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2 (2018) (17)
- Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non–Small Cell Lung Carcinogenesis (2019) (17)
- Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation. (2015) (17)
- Effect of Clustering Algorithm on Establishing Markov State Model for Molecular Dynamics Simulations (2016) (16)
- A selective small‐molecule inhibitor of c‐Jun N‐terminal kinase 1 (2009) (16)
- Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship. (2008) (16)
- Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1–Cα1 germline transcription in epithelial cancer cells (2013) (16)
- Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA (2017) (16)
- TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. (2017) (16)
- Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo (2012) (16)
- Targeting LIMK1 with luteolin inhibits the growth of lung cancer in vitro and in vivo (2021) (15)
- The Role of PGC 1 a in Cancer Metabolism and its Therapeutic Implications (2016) (15)
- Hypermethylation-modulated downregulation of RASSF1A expression is associated with the progression of esophageal cancer. (2011) (15)
- LTA4H regulates cell cycle and skin carcinogenesis (2017) (15)
- Purpurogallin is a novel mitogen‐activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo (2019) (15)
- Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG) (2015) (15)
- Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells (2017) (15)
- Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase. (2020) (14)
- 244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells (2015) (14)
- CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway (2021) (14)
- Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. (2014) (14)
- Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression (2017) (14)
- Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice (2019) (14)
- Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively (2020) (14)
- Involvement of the paxillin pathway in JB6 Cl41 cell transformation. (2006) (14)
- Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo (2021) (14)
- Visualization of two architectures in class-II CAP-dependent transcription activation (2019) (13)
- The PGC-1/ERR network and its role in precision oncology (2019) (13)
- RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth (2017) (13)
- Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo (2021) (13)
- Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin (2016) (13)
- Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1 (2020) (13)
- MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes. (2013) (13)
- RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation (2018) (13)
- Lymphokine-Activated KillerT-Cell-Originated Protein Kinase Phosphorylation of Histone H 2 AX Prevents Arsenite-Induced Apoptosis in RPMI 7951 Melanoma Cells (2006) (12)
- FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma (2018) (12)
- Histone XH2AX Is Required for Xenopus Anterior Neural Development (2010) (12)
- Tpl2 is a key mediator of arsenite-induced signal transduction. (2009) (12)
- Jazf1 promotes prostate cancer progression by activating JNK/Slug (2017) (12)
- Targeting PRPK Function Blocks Colon Cancer Metastasis (2018) (12)
- Src is a novel potential off‐target of RXR agonists, 9‐cis‐UAB30 and Targretin, in human breast cancer cells (2015) (12)
- Small molecule inhibitors of mesotrypsin from a structure-based docking screen (2017) (12)
- Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient‐derived esophageal tumor growth (2019) (12)
- Signal Transduction Molecules as Targets for Cancer Prevention (2009) (12)
- MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance (2018) (12)
- p38α MAPK is required for arsenic‐induced cell transformation (2016) (11)
- Mefloquine Inhibits Esophageal Squamous Cell Carcinoma Tumor Growth by Inducing Mitochondrial Autophagy (2020) (11)
- Anticancer activity of 3-demethylubiquinone Q2. In vivo experiments and probable mechanism of action. (2008) (11)
- Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway (2021) (11)
- Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2 (2018) (11)
- EBV-Encoded LMP1 Upregulates Igκ 3′Enhancer Activity and Igκ Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling (2012) (11)
- Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells (2019) (11)
- Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation (2015) (11)
- Luteolin Inhibits Protein Kinase Cε and c-Src Activities and UVB-Induced Skin Cancer (2010) (11)
- The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth (2017) (11)
- (S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity (2019) (11)
- HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E (2020) (11)
- PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential (2021) (11)
- The Function of Heterodimeric AP-1 Comprised of c-Jun and c-Fos in Activin Mediated Spemann Organizer Gene Expression (2011) (10)
- Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction (2013) (10)
- Grafting assay distinguishes promotion sensitive from promotion resistant JB6 cells. (1997) (10)
- Heterogeneity Analysis of Esophageal Squamous Cell Carcinoma in Cell Lines, Tumor Tissues and Patient-Derived Xenografts (2021) (10)
- Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032 (2020) (10)
- Dinitrosopiperazine‐decreased PKP3 through upregulating miR‐149 participates in nasopharyngeal carcinoma metastasis (2018) (9)
- The CUG-translated WT1, not AUG-WT1, is an oncogene (2017) (9)
- Concerted Dynamic Motions of an FABP4 Model and Its Ligands Revealed by Microsecond Molecular Dynamics Simulations (2014) (9)
- BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression (2021) (8)
- 7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor (2020) (8)
- 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo (2020) (8)
- The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. (2010) (8)
- Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo (2020) (8)
- RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor (2020) (8)
- Beneficial Effects of Resveratrol (2004) (8)
- Structural basis for multifunctional roles of human Ints3 C-terminal domain. (2020) (8)
- PKCι is a target of 7,8,4′‐trihydroxyisoflavone for the suppression of UVB‐induced MMP‐1 expression (2018) (7)
- Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations (2017) (7)
- In vitroAnticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families (2016) (7)
- Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function (2020) (7)
- Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4 (2021) (7)
- 15-Deoxy-Δ12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2 (2016) (7)
- The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K (2018) (7)
- hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways (2017) (7)
- Advances in Brief Arsenic Induces Apoptosis through a c-Jun NH 2-Terminal Kinase-dependent , p 53-independent Pathway 1 (1999) (7)
- Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3 (2021) (6)
- Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research (2010) (6)
- Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo (2021) (6)
- PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy (2022) (6)
- Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light (2017) (6)
- Scutellarin Suppresses Patient-Derived Xenograft Tumor Growth by Directly Targeting AKT in Esophageal Squamous Cell Carcinoma (2019) (6)
- Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17. (2015) (6)
- (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate Suppresses Solar UV-Induced Skin Carcinogenesis by Targeting PI3K, ERK1/2, and p38 (2014) (6)
- CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo. (2013) (6)
- Nuclear factor-erythroid 2-related factor 3 (NRF3) is low expressed in colorectal cancer and its down-regulation promotes colorectal cancer malignance through activating EGFR and p38/MAPK. (2019) (6)
- EPRS/GluRS promotes gastric cancer development via WNT/GSK-3β/β-catenin signaling pathway (2021) (6)
- Crystal structure of the human PRPK–TPRKB complex (2021) (6)
- Targeting nutrient metabolism with FDA-approved drugs for cancer chemoprevention: Drugs and mechanisms. (2021) (5)
- T-lymphokine-activated killer cell-originated protein kinase (TOPK)-positive colorectal tumor growth is suppressed by acetylshikonin. (2020) (5)
- Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development (2019) (5)
- Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma (2022) (5)
- Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1. (1995) (5)
- Genome variation in precision medicine (2016) (5)
- Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells. (2014) (5)
- Promotion-resistant JB6 mouse epidermal cells exhibit defects in phosphatidylethanolamine synthesis and phorbol ester-induced phosphatidylcholine hydrolysis. (1997) (5)
- Exploration of gated ligand binding recognizes an allosteric site for blocking FABP4-protein interaction. (2015) (5)
- Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer (2022) (5)
- Gastric tumorigenesis induced by combining Helicobacter pylori infection and chronic alcohol through IL-10 inhibition. (2021) (5)
- Costunolide suppresses melanoma growth via the AKT/mTOR pathway in vitro and in vivo. (2021) (4)
- APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model. (2017) (4)
- APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model (2017) (4)
- Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer (2020) (4)
- ERK1 Directly Interacts With JNK1 Leading to Regulation of JNK1/c‐Jun Activity and Cell Transformation (2017) (4)
- The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1. (2015) (4)
- (−)-Epigallocatechin-3-Gallate Inhibits EBV Lytic Replication via Targeting LMP1-Mediated MAPK Signal Axes (2021) (4)
- Molecular mechanism of SARS-CoV-2 components caused ARDS in murine model (2020) (4)
- The effect of metformin on the risk of recurrent nonmelanoma skin cancers (2020) (4)
- 3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo (2021) (4)
- Safety of SGLT2 Inhibitors: A Pharmacovigilance Study From 2015 to 2020 Based on FDA Adverse Event Report System Database (2021) (4)
- Statistical analysis of EGFR structures’ performance in virtual screening (2015) (4)
- Correction: Structural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2 (2009) (4)
- Modulation of Cell Signal Transduction by Tea and Ginger (2008) (4)
- ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis (2020) (4)
- Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression (2020) (4)
- Targeting integrin αvβ3 with indomethacin inhibits patient‐derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma (2021) (4)
- Anwulignan is a novel JAK1 inhibitor that suppresses non‐small cell lung cancer growth (2021) (3)
- Skin Cancer and AP-1 Transactivation Inhibitory Effects of Perillyl Alcohol on UVB-induced Murine Updated (2006) (3)
- 2,6-DMBQ suppresses cell proliferation and migration via inhibiting mTOR/AKT and p38 MAPK signaling pathways in NSCLC cells. (2021) (3)
- Gastric tumorigenesis induced either by Helicobacter pylori infection or chronic alcohol consumption through IL-10 inhibition (2020) (3)
- Molecular Targets of Coffee Phytochemicals Caffeic Acid and Chlorogenic Acid in Chemoprevention (2015) (3)
- MST 1 Promotes Apoptosis through Phosphorylation of Histone H 2 AX * (2010) (3)
- Cocoa Procyanidins Suppress Transformation by Inhibiting (2008) (3)
- Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo (2020) (3)
- Flavonol in Red Wine for the Chemopreventive Effect of Quercetin , a Major Raf and MEK Protein Kinases Are Direct Molecular Targets (2008) (3)
- - deficient Murine Fibroblast Cells Jnk 2-and Jnk 1 Differential Gene Expression Profiles of Updated (2002) (3)
- Bestatin cream impairs solar simulated light-driven skin inflammation and skin carcinogenesis in mice. (2021) (3)
- PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts (2016) (3)
- Select Dietary Phytochemicals Function as Inhibitors of COX-1 but Not COX-2 (2013) (3)
- GSK3β-Mediated Expression of CUG-Translated WT1 Is Critical for Tumor Progression (2020) (3)
- Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention (2011) (2)
- Abstract 4440: TRAF4 is a key molecule for lung cancer through regulating AKT ubiquitination and activation (2014) (2)
- Regulation of A^-NitrosodimethylamineDemethylase in Rat Liver and Kidney1 (1987) (2)
- Abstract 1241: Kaempferol suppresses solar ultraviolet radiation-induced skin cancers by targeting RSK2 and MSK1 (2014) (2)
- Molecular and Cellular Pathobiology Phosphorylation of H 2 AX at Ser 139 and a New Phosphorylation Site Ser 16 by RSK 2 Decreases H 2 AX Ubiquitination and Inhibits Cell Transformation (2011) (2)
- Desmethylubiquinone Q2 from the Far-Eastern Ascidian Aplidium glabrum: Structure and Synthesis. (2005) (2)
- 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo (2021) (2)
- Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo (2022) (2)
- Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array. (2012) (2)
- Analysis of hydrophobic and hydrophilic moments of short penetrating peptides for enhancing mitochondrial localization: prediction and validation (2019) (2)
- Human αA- and αB-crystallins prevent UVA-induced apoptosis through regulation of PKCα, RAF/MEK/ERK and AKT signaling pathways [Experimental Eye Research 79 (2004) 393–403] (2004) (2)
- Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy (2021) (2)
- hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16INK4a under hypoxic conditions (2017) (2)
- TOPK phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells (2008) (2)
- Abstract #4400: Cdk3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation (2009) (2)
- N,N'-Dinitrosopiperazine-mediated ezrin phosphorylation via activating Rho kinase and protein kinase C involves in metastasis of nasopharyngeal carcinoma 6-10B cells (2011) (2)
- ATM, MAPKs and RSK2 Are Involved in the Phosphorylation of STAT3* (2003) (1)
- Abstract 154: [6]-Shogaol inhibits cell growth and induces apoptosis in non-small-cell lung cancer (NSCLC) cells by regulating multiple targets (2012) (1)
- Abstract 2127: RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth (2018) (1)
- 244-MPT over comes gefitinib resistance in non-small cell lung cancer cells (2015) (1)
- Mitogen- and stress-activated kinase 1 (MSK1) is required for neoplastic cell transformation (2008) (1)
- Retraction of “MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance” (2021) (1)
- COVID-19 and Strategies for Its Therapeutics. (2020) (1)
- Erratum to: Glycolytic genes in cancer cells are more than glucose metabolic regulators (2014) (1)
- Abstract 1590: Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3-K (2012) (1)
- Abstract 361: Large scale virtual screening to identify novel inhibitors of Fyn as potential drugs for cancer treatment (2010) (1)
- Proceedings—targeting carcinogenesis: Transduction, transcription, translation (2006) (1)
- Abstract 1034: A natural inhibitor of c-Jun N-terminal kinase 1 (2011) (1)
- Abstract 5153: PAK2-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. (2013) (1)
- Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity (2022) (1)
- Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A (2022) (1)
- Abstract 222: NEK6 promotes JB6 C141 cell transformation and activates STAT3 through its phosphorylation on Ser727 (2012) (1)
- Abstract 1227: Inhibition of the RSK2-ATF1 signaling axis by eriodictyol suppresses neoplastic cell transformation (2010) (1)
- Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells (2020) (1)
- Abstract 1589: Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K (2012) (1)
- Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells (2012) (1)
- The caffeine analogue, 1-hexyl-3-propyl-7-methylxanthine inhibits malignant transformation and stimulates apoptosis and intracellular cAMP content in JB6 cells (2006) (1)
- Abstract 4573: 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1 (2015) (1)
- Abstract 2680: Nonautoinhibitory properties of the C-terminal helix of the mitogen- and stress-activated protein kinase 1 (2010) (1)
- Cancer Prevention (2014) (1)
- Abstract 3673: Expression profile of phosphorylated proteins from the mTOR and Fyn/RSK2 signaling pathways in solar UV-induced skin carcinogenesis (2011) (1)
- Advances in Brief Differential Gene Expression Profiles of Jnk 1-and Jnk 2-deficient Murine Fibroblast Cells 1 (2002) (1)
- Abstract 2884: Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase (2011) (1)
- Abstract 2244: Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice (2017) (1)
- hYSK 1 promotes cancer cell proliferation and migration through negative regulation of p 16 INK 4 a under hypoxic conditions (2017) (1)
- Ubiquitination of ADRα1d/SerpinA1 complex stimulates hypoxia to induce gastric tumorigenesis with a combination of Helicobacter pylori and chronic stress through IL-1α (2022) (1)
- Regulation of microRNAs by epigenetics and their interplay involved in cancer (2013) (1)
- Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC (2022) (1)
- A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells (2013) (1)
- Abstract 167: Myricetin suppresses UVB-induced photoaging, skin cancer, and angiogenesis by targeting multiple kinases (2012) (1)
- Advances in Brief Inhibition of Epidermal Growth Factor-induced Cell Transformation and Activator Protein 1 Activation by [ 6 ]-Gingerol 1 (2001) (1)
- Abstract 4972: Phosphorylation of caspase-3 and caspase-7 by p21-activated protein kinase (PAK)2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines (2012) (1)
- Mechanisms Involved-transformed Cells : Structure-Activity Relationship and ras Purified Green Tea and Black Tea Polyphenols in H-Inhibition of Activator Protein 1 Activity and Cell Growth by Updated (1999) (0)
- 3,3'-Diindolylmethane plus Eflornithine suppress DNA Replication and Cell Cycle in Esophageal Squamous Cell Carcinoma in vivo (2022) (0)
- Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. (2004) (0)
- Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo (2021) (0)
- Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint (2023) (0)
- Abstract C013: HI-B9 suppresses colorectal cancer by inhibiting Wnt/β-catenin pathway (2019) (0)
- Allan H. Conney: In Memoriam (1930–2013) (2013) (0)
- Running head : Antagonistic Role of ERK 1 on JNK Activity (2017) (0)
- From the editors (2009) (0)
- Crystal structure of the human PRPK–TPRKB complex (2021) (0)
- 2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative (2007) (0)
- Abstract 2471: Direct down-regulation of eEF1A2 by Tumor suppressor p16INK4ainhibits cancer cell growth (2014) (0)
- Cancer esearch apeutics , Targets , and Chemical Biology arcinogenic Effect of Capsaicin Involves Activation R GFR Signaling but Not TRPV 1 (2010) (0)
- Molecular and Cellular Pathobiology Identi fi cation of an Aurora Kinase Inhibitor Speci fi c for the Aurora B Isoform (2013) (0)
- Chemopreventive Effects of Licorice and Its Components (2015) (0)
- Erratum (2016) (0)
- Ipriflavone Suppresses Growth of Esophageal Squamous Cell Carcinoma Through Inhibiting mTOR In Vitro and In Vivo (2021) (0)
- Cancer Prevention Studies in High-Risk Areas of Traditional Chinese Cancers (2015) (0)
- Abstract 3509: Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability (2016) (0)
- Abstract 2589: The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. (2013) (0)
- Abstract 4780: Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures (2012) (0)
- 229 LOCAL AND SYSTEMIC ANTI-INFLAMMATORY EFFECTS OF ω3 FATTY ACIDS IN BARRETT'S ESOPHAGUS PATIENTS: RESULTS FROM A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL (2021) (0)
- Abstract 4777: Computational strategies for finding protein targets of flavonoids (2012) (0)
- Abstract 2669: Crystal structure of the active N-terminal kinase domain of p90 ribosomal S6 protein kinase 2 (2010) (0)
- Abstract 2469: RCC2 promotes esophageal cancer growth by regulating activity and expression of the Sox2 transcription factor (2020) (0)
- Kinase-dependent , p 53-independent Pathway-Terminal 2 Arsenic Induces Apoptosis through a c-Jun NH Updated (1999) (0)
- Abstract 1718: Down-regulation of p16INK4aby hYSK1 promotes cancer cell migration under hypoxic conditions (2019) (0)
- Cancer prevention : dietary factors and pharmacology (2014) (0)
- Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals (2013) (0)
- Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP (2010) (0)
- The Lactate Receptor GPR81 Stabilizes A20 to Protect Against Colitis and Colitis-Associated Colonic Tumorigenesis in Mice (2022) (0)
- Abstract 5746: TRAF1 is required for solar UV-induced skin carcinogenesis (2017) (0)
- Abstract 549: The CUG-translated WT1, not AUG-WT1, is an oncogene (2018) (0)
- Abstract 6380: Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032 (2020) (0)
- Abstract 2234: Catechol suppresses EGF-induced cell transformation by inhibiting ERK2 activity as confirmed by a crystallographic study. (2013) (0)
- Abstract 4277: TRAF2 is a key mediator of the EGF-induced signaling pathway. (2013) (0)
- Microsoft Word-TRAF2-RSK2-JBC-R1 (2012) (0)
- Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function (2020) (0)
- RETRACTED ARTICLE: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance (2018) (0)
- Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19 (2022) (0)
- PHLDA1 Promotes Glioblastoma Oncogenesis via Ras/Mek/Erk Signaling Pathway (2021) (0)
- Abstract 821: Discovery of catechol moiety-containing natural compounds as direct ERK2 inhibitors by in vitro kinase assay and co-crystallography (2016) (0)
- Abstract 1252: 6-c-(e-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1 (2014) (0)
- Abstract 2235: Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. (2013) (0)
- Heterogeneity Analysis of Esophageal Squamous Cell Carcinoma for Precision Oncology Research (2020) (0)
- mmation and Pancreatic Tumorigenesis (2010) (0)
- 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo (2020) (0)
- Crystal structure of the C-terminal kinase domain of MSK1 (2010) (0)
- Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase (2023) (0)
- A chrysin derivative inhibits cell transformation (2013) (0)
- Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor (2012) (0)
- overcomes gefitinib resistance in non-small cell lung cancer cells (2015) (0)
- 575 Immunohistochemical evaluation of proteins within UV signal transduction pathways in the progression of normal human skin to matched sun-damaged skin and actinic keratosis (2016) (0)
- Abstract 4968: Phosphorylation of caspase-8 (Thr263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability (2012) (0)
- Erratum: Protein phosphatase-2A is a target of epigallocatechin-3-gailate and modulates p53-Bak apoptotic pathway. (Cancer Res (2008) 68 (4150-62)) (2008) (0)
- Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo (2021) (0)
- Molecular targets for cancer prevention by tea polyphenols. (2006) (0)
- Naringenin Suppresses UVB-induced Photoaging by Targeting ERK2 (2015) (0)
- Abstract CN07-02: Molecularly targeted cancer prevention: From discovery to medicine (2011) (0)
- Abstract 4509: Epigallocatechin gallate suppresses tumorigenesis of lung cancer cells by targeting Ras-GTPase-activating protein SH3-domain binding protein 1 (2010) (0)
- Abstract 1080: Computational and biochemical discovery of RSK2 as a novel target for epigallocatechin gallate (EGCG) (2015) (0)
- Functional proteomics analysis of components of signaling pathways triggered by Epstein-Barr virus-encoded oncoprotein latent membrane protein 1 via novel phosphoprotein enrichment (2005) (0)
- A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC (2022) (0)
- Structural basis for multifunctional roles of human Ints3 C-terminal domain (2020) (0)
- Chaperone Glucose-Regulated Protein 78 Etoposide-Induced Cell Death by Targeting the Molecular Epigallocatechin Gallate Overcomes Resistance to − ) (2006) (0)
- Pairing Cancer Biomarkers to Biomedicine (2017) (0)
- Abstract 1917: Targeting wildtype and L858R/T790M mutant EGFR by isoliquiritigenin induces apoptosis and Inhibits tumor growth of NSCLC (2015) (0)
- Strategies for identifying molecular targets for cancer chemoprevention (2013) (0)
- Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate (2011) (0)
- Abstract 2959: Deoxysappanchalcone inhibits cell growth by regulation of TOPK signaling pathway in colon cancer (2019) (0)
- Abstract 4391: Disruption of the translation initiation complex by eIF4A mutant inhibits prostate tumor growthin vivo (2019) (0)
- Abstract ED01-03: Forward and backward cell transformation induced by microenvironment factors: A tribute to Allan H. Conney (2013) (0)
- Erratum to: Glycolytic genes in cancer cells are more than glucose metabolic regulators (2014) (0)
- Nutritional Prevention of Cancer: Challenges and New Directions (2016) (0)
- APOPTOSIS, CANCER, AND OVEREXPRESSION OF PROTEINS Cancer Prevention by Food Factors Through Targeting Signal Transduction Pathways (2004) (0)
- How to Predict Cancer-Specific Death of Patients with Chondrosarcoma: A Prognostic Model Based on Competing Risk (2021) (0)
- Abstract 2373: ADA-07 suppresses solar ultraviolet-induced skin carcinogenesis by directly inhibiting TOPK (2018) (0)
- Application of virtual screening, reverse-docking and molecular dynamics simulations in computational biology and drug design (2013) (0)
- 764 A novel strategy for topical photochemoprevention: Pharmacological TLR4 antagonism blocks non-melanoma skin cancer (2017) (0)
- 085 TLR4 as a novel molecular target for non-melanoma skin cancer prevention (2016) (0)
- Daurisoline Suppresses Growth of Esophageal Squamous Cell Carcinoma by Inhibiting MEK1/2 In Vitro and In Vivo (2021) (0)
- GFR Signaling but Not TRPV1 (2010) (0)
- The Hormel Institute International Cancer Research Conference—2017 meeting report (2018) (0)
- Combining Computational and Experimental Methods for Identifying Molecular Targets of Phytochemicals (2014) (0)
- Abstract 1055: Effect of embryonic stem (ES) cell-conditioned microenvironment on the reprogramming of melanoma (2011) (0)
- Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma. (2022) (0)
- FIGURE 7.3, [The anticancer activities exerted by ginger.]. (2011) (0)
- Abstract 2337: Effect of embryonic stem (ES) cell-conditioned microenvironment on the reprogramming of human cancer (2010) (0)
- Abstract CN08-01: Computerized approaches to molecularly-designed drugs and target identification for cancer prevention (2012) (0)
- Abstract 2021: Ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis through upregulation of keratin-17 (2017) (0)
- Abstract 5055: TOPK phosphorylation of Prx1 at Ser32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of its peroxidase activity and blockade of intracellular accumulation of H2O2 (2010) (0)
- Abstract 1113: Targeting PRPK function blocks colon cancer metastasis (2019) (0)
- Abstract 1017: Phosphorylation of histone H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation (2011) (0)
- Abstract 4798: The Ashitaba (Angelica keiskei) chalcones 4-hydroxyderricin and xanthoangelol suppress melanomagenesis by targeting BRAF and PI3-K (2019) (0)
- Abstract #3116: Heterodimeric AP-1 (JunD/c-Fos) is involved in hematopoiesis in synergy with BMP-4 during vertebrate developmen (2009) (0)
- Mefloquine Inhibited Esophageal Squamous Cells Carcinoma Proliferation by Induction of Mitochondrial Autophagy (2019) (0)
- Abstract 5450: Anticancer effects of picrasidine Q fromAngelica keiskion esophageal squamous cell carcinoma by downregulation of FGFR2 signaling pathways (2018) (0)
- (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus lytic replication involves latent membrane protein 1-mediated MAPK signaling pathways (2018) (0)
- Orobol, 3'-hydroxy-genistein, suppresses the development and regrowth of cutaneous SCC. (2023) (0)
- Epigallocatechin 3-Gallate and Green Tea Catechins : United They Work , Divided They Fail Perspective (2009) (0)
- NFAT3, a substrate of JNKs, is a negative regulator of Ras-JNK-induced cell transformation (2007) (0)
- Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma (2023) (0)
- Abstract 3582: Licochalcone-A, a natural inhibitor of c-Jun N-terminal kinase 1. (2013) (0)
- Nutrient Signaling – Protein Kinase to Transcriptional Activation (2010) (0)
- Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma (2022) (0)
- Abstract 3178: Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation (2014) (0)
- Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance (2021) (0)
- Abstract 2325: The crystal structure of the ERK2/norathyriol complex (2011) (0)
- Abstract 1443: Inhibiting HMG-CoA reductase suppresses non-small cell lung carcinogenesis (2020) (0)
- Abstract 536: Targeting PRPK and TOPK for skin cancer prevention and therapy (2018) (0)
- Abstract 422: IL-10 inhibition accelerates gastric tumorigenesis in mice with eitherHelicobacter pyloriinfection or chronic alcohol intake (2020) (0)
- Prevention and Therapy of Cancer by Food Factors through p53-Dependent or -Independent Apoptosis (2003) (0)
- Involvement of sphingomyelinase in insulin‐induced phosphatidylinositol 3‐kinase activation (2001) (0)
- Four Is Better Than 1—Strength in Numbers! (2016) (0)
- Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance (2021) (0)
- Abstract 2601: A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer in vitro and in vivo (2015) (0)
- Abstract 1960: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK)2 inhibits staurosporine-induced apoptosis of MCF-7 breast cancer cells (2011) (0)
- Abstract 1029: Identification of novel MEK1 inhibitors by computer docking and virtual screening (2011) (0)
- PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras (2022) (0)
- Chapter 7 The Amazing and Mighty Ginger (2019) (0)
- PKCι Is a Promising Target Suppressing UVB-Induced MMP- 1 Expression by 7,8,4’-Trihydroxyisoflavone (2014) (0)
- Abstract 2593: Inhibition of COX1/2-driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development (2020) (0)
- Molecular and Cellular Pathobiology TRAF 4 Is aCriticalMolecule for Akt Activation in LungCancer (2013) (0)
- Abstract 4447: Structural basis of human translation initiation factor eIF4G-enhanced helicase activity of eIF4A in tumorigenesis (2018) (0)
- Abstract B55: Involvement of RSK2 in human skin cancer (2012) (0)
- Abstract 224: TOPK phosphorylation of MKP1 prevents solar ultraviolet irradiation-induced inflammation by inhibiting p38 signaling (2012) (0)
- Arbidol inhibits human esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase (2022) (0)
- Abstract 2904: Docking-based virtual screening of Chk1 inhibitors (2011) (0)
- cells . transactivation and transformation in JB 6 P + in epidermal growth factor-induced AP-1 Requirement for phosphatidylinositol 3-kinase (1996) (0)
- Glycolytic genes in cancer cells are more than glucose metabolic regulators (2014) (0)
- Abstract 1346: Discovery of novel MSK1 inhibitors with hybrid virtual screening and structure-based drug design (2011) (0)
- CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway (2021) (0)
- PDTM-38. HISTONE H3.3 SER31 PHOSPHORYLATION REGULATES CHROMOSOME SEGREGATION AND CELL CYCLE CHECKPOINT CONTROL AND IS IMPAIRED IN PEDIATRIC GLIOMAS (2019) (0)
- TOPK Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Activating Src/GSK3β/STAT3 Signal Pathway though γ-catenin (2019) (0)
- miR‐132‐3p promotes heat stimulation‐induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2 (2023) (0)
- 2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2) (2007) (0)
- Targeting EPRS is an Effective Therapeutic Strategy for Gastric Cancer (2020) (0)
- Abstract 3839: A small-molecule inhibitor of the β-catenin-TCF4 interaction suppresses colorectal cancer growth in vitro and in vivo (2018) (0)
- Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma (2012) (0)
- Aspirin Suppresses Breast Cancer Metastasis by Targeting Anoikis Resistance (2021) (0)
- Abstract 4299: Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinomain vitroand patient-derived xenograftsin vivo (2019) (0)
- Preliminary Study on the Role and Mechanism of KIRREL3 in the Development of Esophageal Squamous Cell Carcinoma (ESCC) (2021) (0)
- Abstract 5810: Fyn kinase negatively regulates telomere length in stem cells and cancer cells (2020) (0)
- Targeting the STAT5A/IDO1 Axis Overcomes Radiotherapy Resistance and Reverses Immunosuppressive Tumor Microenvironment in Non-Small Cell Lung Cancer (2022) (0)
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What Schools Are Affiliated With Zigang Dong?
Zigang Dong is affiliated with the following schools:
