Don W. Cleveland

Q: What Schools Are Affiliated With Don W. Cleveland

Don W. Cleveland is affiliated with the following schools: McGill University, University of Sussex, University of Oxford, University of California, San Diego, Princeton University, University of Basel, Johns Hopkins University, University of California, San Francisco, New Mexico State University

Don W. Cleveland's AcademicInfluence.com Rankings

Don W. Cleveland

Biology

#918

World Rank

#1604

Historical Rank

#491

USA Rank

Neuroscience

#102

World Rank

#109

Historical Rank

#44

USA Rank

biology Degrees

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Biology

Why Is Don W. Cleveland Influential?

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According to Wikipedia, Don W. Cleveland is an American cancer biologist and neurobiologist. Cleveland is currently the Department Chair of Cellular and Molecular Medicine and Distinguished Professor of Medicine, Cellular and Molecular Medicine and Neurosciences at the University of California at San Diego, and Head, Laboratory for Cell Biology at the San Diego branch of Ludwig Cancer Research.

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Don W. Cleveland's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. (1977) (4468)
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia (2006) (1516)
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria (1995) (1484)
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors (2006) (1396)
Unraveling the mechanisms involved in motor neuron degeneration in ALS. (2004) (1371)
From charcot to lou gehrig: deciphering selective motor neuron death in als (2001) (1353)
Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes (1980) (1345)
Decoding ALS: from genes to mechanism (2016) (1331)
Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis (2013) (1329)
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions (1997) (1327)
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. (1998) (1191)
On the road to cancer: aneuploidy and the mitotic checkpoint (2005) (1191)
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice (2003) (1078)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 (2011) (1041)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis (2008) (1030)
A structural scaffolding of intermediate filaments in health and disease. (1998) (1021)
Centromeres and Kinetochores From Epigenetics to Mitotic Checkpoint Signaling (2003) (1014)
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond (2009) (926)
The selection-mutation-drift theory of synonymous codon usage. (1991) (916)
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. (2010) (897)
The Effect of Selection on Genetic Variability (1971) (884)
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. (1977) (837)
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) (2002) (816)
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis (2009) (803)
Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. (1977) (788)
Chromosomal instability drives metastasis through a cytosolic DNA response (2017) (766)
A standardized kinesin nomenclature (2004) (750)
Aneuploidy acts both oncogenically and as a tumor suppressor. (2007) (731)
The Mathematical Theory of Quantitative Genetics (1981) (718)
High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. (1984) (716)
Neurofilament gene expression: a major determinant of axonal caliber. (1987) (708)
The human CENP-A centromeric nucleosome-associated complex (2006) (688)
Analysis of the inheritance, selection and evolution of growth trajectories. (1990) (674)
Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP (2009) (634)
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs (2012) (625)
Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis (2012) (616)
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. (1994) (615)
Propagation of centromeric chromatin requires exit from mitosis (2007) (600)
The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. (1990) (589)
A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly (1996) (587)
Rethinking ALS: The FUS about TDP-43 (2009) (579)
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease (1993) (573)
Does aneuploidy cause cancer? (2006) (523)
Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria (2004) (519)
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. (2005) (513)
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein (1991) (510)
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration (2013) (507)
Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons (1999) (477)
γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation (1992) (472)
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis (2013) (465)
Antisense oligonucleotide therapy for neurodegenerative disease. (2006) (450)
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas Potentiation by ALS-Linked SOD1 Mutations (2002) (444)
Molecular biology and genetics of tubulin. (1985) (438)
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. (2004) (431)
CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment (1997) (430)
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) (425)
CENP-E is a putative kinetochore motor that accumulates just before mitosis (1992) (422)
Structural determinants for generating centromeric chromatin (2004) (414)
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration (2008) (410)
Neurofilaments are obligate heteropolymers in vivo (1993) (405)
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS (2010) (400)
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs (2016) (396)
CENP‐E, a novel human centromere‐associated protein required for progression from metaphase to anaphase. (1991) (388)
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen (1987) (384)
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint (2000) (382)
A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease (1994) (378)
Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. (1986) (377)
Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint (2001) (362)
Unpolymerized tubulin modulates the level of tubulin mRNAs (1981) (361)
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 (2013) (354)
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. (2000) (347)
Dynamics of Centromere and Kinetochore Proteins Implications for Checkpoint Signaling and Silencing (2004) (343)
Formation of Spindle Poles by Dynein/Dynactin-Dependent Transport of Numa (2000) (342)
Theoretical Evolutionary Ecology (1994) (341)
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond (2011) (336)
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. (1995) (329)
Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A (2003) (321)
The Seeds of Neurodegeneration: Prion-like Spreading in ALS (2011) (320)
An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments (1996) (320)
Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes (2011) (314)
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. (2002) (313)
Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs (1981) (307)
Waiting for Anaphase Mad2 and the Spindle Assembly Checkpoint (2000) (307)
Neuronal intermediate filaments. (1996) (306)
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. (1997) (298)
On Fitting the Poisson Lognormal Distribution to Species-Abundance Data (1974) (291)
Coevolution of codon usage and transfer RNA abundance (1987) (290)
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS (2013) (287)
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading (2002) (283)
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice (2008) (279)
Two distinct classes of keratin genes and their evolutionary significance (1981) (276)
Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. (1988) (273)
ZW10 links mitotic checkpoint signaling to the structural kinetochore (2005) (272)
Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin (1988) (268)
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss (2003) (268)
Losing balance: the origin and impact of aneuploidy in cancer (2012) (267)
Cep152 interacts with Plk4 and is required for centriole duplication (2010) (267)
Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS (2010) (266)
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria (2008) (266)
Activating and Silencing the Mitotic Checkpoint through CENP-E-Dependent Activation/Inactivation of BubR1 (2003) (264)
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. (2009) (264)
Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions (1983) (260)
Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. (2017) (259)
Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. (2007) (258)
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death (2019) (255)
Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells (2012) (252)
CENP-E as an Essential Component of the Mitotic Checkpoint In Vitro (2000) (252)
Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression (2012) (251)
Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability (2010) (251)
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors (2014) (250)
A two-step mechanism for epigenetic specification of centromere identity and function (2013) (247)
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. (1998) (244)
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins (2016) (242)
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. (1988) (241)
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. (1980) (241)
From Charcot to SOD1 Mechanisms of Selective Motor Neuron Death in ALS (1999) (239)
Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E (2010) (232)
Stochastic Population Models in Ecology and Epidemiology (1961) (231)
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration (2018) (230)
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS (2007) (229)
In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens (1987) (226)
The Microtubule-dependent Motor Centromere–associated Protein E (CENP-E) Is an Integral Component of Kinetochore Corona Fibers That Link Centromeres to Spindle Microtubules (1997) (225)
Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements (2012) (224)
Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis (1992) (223)
Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. (2001) (219)
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. (1998) (217)
Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. (1998) (214)
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors (2013) (208)
HERITABILITY OF SEX RATIO IN TURTLES WITH ENVIRONMENTAL SEX DETERMINATION (1982) (206)
Local mate competition and the sex ratio (1980) (203)
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. (2010) (200)
The multitubulin hypothesis revisited: what have we learned? (1987) (200)
ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP (2015) (198)
Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs (1987) (197)
Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS (2008) (196)
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis (2007) (194)
DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. (2015) (193)
Tubulin requires tau for growth onto microtubule initiating sites. (1976) (192)
Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport (1996) (192)
The quantitative architecture of centromeric chromatin (2014) (191)
Reversing Parkinson Disease Model with in situ Converted Nigral Neurons (2020) (191)
Aneuploidy: instigator and inhibitor of tumorigenesis. (2007) (189)
A Statistical Analysis of the 10-Year Cycle in Canada (1974) (189)
Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. (1992) (187)
Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. (1999) (183)
Prion-like spread of protein aggregates in neurodegeneration (2012) (183)
Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. (1993) (181)
Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice (2014) (179)
Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit (1990) (178)
Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice (2009) (178)
Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS. (2013) (177)
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. (2009) (176)
Pathways of Spindle Pole Formation: Different Mechanisms; Conserved Components (1997) (176)
New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: Inclusions containing SOD1 in neurons and astrocytes (2000) (176)
Differential utilization of beta-tubulin isotypes in differentiating neurites (1989) (174)
MODELS OF POLYGENIC SEX DETERMINATION AND SEX RATIO CONTROL (1982) (174)
The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation (1993) (173)
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining (2016) (172)
Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber (1990) (171)
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling (2005) (169)
Introduction to the mathematical theory of genetic linkage (1962) (169)
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis (2006) (167)
Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis (2013) (167)
Subunit composition of neurofilaments specifies axonal diameter (1996) (165)
Reduced synonymous substitution rate at the start of enterobacterial genes. (1993) (165)
Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. (2019) (164)
An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes (2007) (164)
Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons (1995) (163)
Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. (1998) (163)
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. (2012) (163)
Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. (1988) (161)
Superoxide Dismutase 1 Subunits with Mutations Linked to Familial Amyotrophic Lateral Sclerosis Do Not Affect Wild-type Subunit Function (*) (1995) (160)
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport (2017) (160)
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import (2010) (159)
Local Control of Neurofilament Accumulation during Radial Growth of Myelinating Axons in Vivo (2000) (157)
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS (2018) (154)
NuMA after 30 years: the matrix revisited. (2010) (153)
Neurofilament-dependent Radial Growth of Motor Axons and Axonal Organization of Neurofilaments Does Not Require the Neurofilament Heavy Subunit (NF-H) or Its Phosphorylation (1998) (151)
Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders. (1991) (150)
NF-M is an essential target for the myelin-directed “outside-in” signaling cascade that mediates radial axonal growth (2003) (149)
Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. (2017) (146)
Delayed germination of seeds: Cohen's model revisited (1984) (145)
A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin. (1988) (145)
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons (2007) (144)
Peptide mapping in one dimension by limited proteolysis of sodium dodecyl sulfate-solubilized proteins. (1983) (144)
CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. (2007) (143)
Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides (1988) (142)
Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis (1994) (142)
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS (2015) (141)
Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease. (1994) (141)
Multiple Niche Polymorphism (1972) (138)
Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. (1989) (138)
Double-strand DNA breaks recruit the centromeric histone CENP-A (2009) (137)
Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy (2014) (137)
Synthetic CRISPR RNA-Cas9–guided genome editing in human cells (2015) (137)
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether (2008) (134)
Requirements for NuMA in maintenance and establishment of mammalian spindle poles (2009) (133)
Selection for Iteroparity in a Variable Environment (1985) (133)
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport (2002) (132)
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis (2018) (132)
The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein (2020) (131)
Are codon usage patterns in unicellular organisms determined by selection‐mutation balance? (1988) (131)
Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. (2008) (130)
Dispersal and the sex ratio (1980) (130)
Models for the evolution of protandry in insects (1983) (128)
Ability of the c-mos product to associate with and phosphorylate tubulin. (1991) (127)
Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension (2012) (127)
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein (2021) (127)
High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal* (2002) (127)
Chromothripsis drives the evolution of gene amplification in cancer (2020) (126)
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. (2012) (126)
Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. (1977) (126)
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips (2013) (123)
Molecular biology of the cytoskeleton (1984) (122)
The effect of selection on genetic variability: a simulation study. (1976) (121)
Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset (2011) (121)
Virus‐delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis (2005) (120)
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation (2018) (119)
The Copper Chaperone CCS Is Abundant in Neurons and Astrocytes in Human and Rodent Brain (1999) (119)
Assortative mating (1977) (119)
Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence (1978) (118)
The genetic variability of polygenic characters under optimizing selection, mutation and drift. (1972) (118)
Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M (1990) (117)
Elevation of tubulin levels by microinjection suppresses new tubulin synthesis (1983) (117)
NuMA is required for the proper completion of mitosis (1993) (116)
MYC Is a Major Determinant of Mitotic Cell Fate (2015) (113)
Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits (1989) (112)
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells (2020) (112)
Unstable microtubule capture at kinetochores depleted of the centromere‐associated protein CENP‐F (2005) (112)
Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. (1992) (111)
Use of the Method of Generalized Least Squares in Reconstructing Phylogenies from Sequence Data (1991) (111)
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 (2020) (111)
Diversity among tubulin subunits: toward what functional end? (1990) (110)
Centrosomes, chromosome instability (CIN) and aneuploidy. (2012) (110)
Multiple determinants of eukaryotic mRNA stability. (1989) (110)
Axonal Transport of Mutant Superoxide Dismutase 1 and Focal Axonal Abnormalities in the Proximal Axons of Transgenic Mice (1998) (110)
Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds (1991) (109)
Maintenance of genetic variability by mutation–selection balance: a child's guide through the jungle (1989) (108)
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation (1987) (108)
Cytoplasmic O-GlcNAc Modification of the Head Domain and the KSP Repeat Motif of the Neurofilament Protein Neurofilament-H* (1996) (107)
Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death (2008) (106)
A dispersed multigene family encoding tubulin in Drosophila melanogaster (1980) (105)
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis (2005) (105)
Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease (1996) (105)
Neighboring base effects on substitution rates in pseudogenes. (1986) (104)
Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation (2012) (102)
Pathogenesis of two axonopathies does not require axonal neurofilaments (1998) (102)
Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. (2013) (101)
Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72 (2015) (101)
The evolution of anisogamy: a game-theoretic approach (2002) (100)
Human Zwint-1 Specifies Localization of Zeste White 10 to Kinetochores and Is Essential for Mitotic Checkpoint Signaling* (2004) (98)
Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? (1983) (98)
Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. (1987) (97)
The statistical analysis of density dependence. (1975) (96)
Density-Dependent Selection and Character Displacement (1974) (96)
Periodical Insects (1977) (96)
Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease (2003) (96)
Oxidation versus aggregation — how do SOD1 mutants cause ALS? (2000) (95)
Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. (2008) (95)
Beyond Nuclear Transport: Ran-Gtp as a Determinant of Spindle Assembly (1999) (94)
NuMA is required for the proper completion of mitosis. (1993) (94)
NuMA, a nuclear protein involved in mitosis and nuclear reformation. (1994) (93)
Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers (2015) (93)
Autoregulated control of tubulin synthesis in animal cells. (1989) (93)
Codon usage and intragenic position. (1988) (92)
Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements (2019) (92)
Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes (2008) (92)
Sequence variants in human neurofilament proteins: Absence of linkage to familial amyotrophic lateral sclerosis (1996) (91)
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1 (2015) (90)
The aneuploidy paradox in cell growth and tumorigenesis. (2008) (89)
Sex ratio theory in geographically structured populations (1986) (88)
Sequences that confer β-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a β-tubulin mRNA (1987) (88)
Slow axonal transport: fast motors in the slow lane. (2002) (87)
The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. (1996) (86)
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases (2006) (86)
Inbreeding in the great tit (1973) (86)
Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation (2009) (85)
Isolation of separate mRNAs for α- and β-Tubulin and characterization of the corresponding in vitro translation products (1978) (84)
Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. (1994) (84)
Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism (2014) (83)
A chemical tool box defines mitotic and interphase roles for Mps1 kinase (2010) (83)
CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. (2016) (83)
CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. (2000) (83)
AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. (1994) (81)
The role of NuMA in the interphase nucleus. (1998) (80)
Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. (2005) (79)
Involvement of neurofilaments in the radial growth of axons (1991) (79)
Four unique genes required for β tubulin expression in vertebrates (1983) (79)
The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease (2007) (78)
The role of aneuploidy in promoting and suppressing tumors (2009) (78)
An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs (1994) (78)
Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression (1985) (78)
Synonymous substitution rates in enterobacteria. (1995) (78)
Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation (2000) (77)
Programmed expression of beta-tubulin genes during development and differentiation of the chicken (1984) (76)
Progressive spinal axonal degeneration and slowness in ALS2‐deficient mice (2006) (76)
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation (2019) (76)
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS (2015) (75)
Sex ratio under the haystack model. (1980) (73)
Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease (1996) (73)
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition (2017) (73)
Non-Random Sequences in Visual Threshold Experiments (1956) (72)
Intermediate filaments and their associated proteins: multiple dynamic personalities. (1998) (71)
Misfolded SOD1 is not a primary component of sporadic ALS (2017) (71)
Toxic mutants in Charcot's sclerosis (1995) (69)
The maintenance of the genetic variability of polygenic characters by heterozygous advantage. (1973) (69)
Pre‐adult viability differences of melanic Biston betularia (L.) (Lepidoptera) (1980) (68)
Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. (2016) (67)
Structural instability of models of sexual selection. (1989) (66)
Linkage disequilibrium and genetic variability. (1974) (65)
Chronic centrosome amplification without tumorigenesis (2015) (64)
Oxidative Stress and Iron Are Implicated in Fragmenting Vacuoles of Saccharomyces cerevisiae Lacking Cu,Zn-Superoxide Dismutase* (1999) (64)
CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II. (1997) (63)
Phase Relations in the Ten-Year Cycle (1975) (63)
Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. (1979) (63)
A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. (1990) (63)
Selective differences among translation termination codons. (1988) (62)
In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function (1987) (60)
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice (2013) (60)
The effect of context on synonymous codon usage in genes with low codon usage bias. (1990) (59)
Cell biology: Nondisjunction, aneuploidy and tetraploidy (2006) (58)
Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis (2006) (58)
NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation. (1995) (58)
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS (2019) (58)
APPROXIMATE CONFIDENCE LIMITS FOR COMPONENTS OF VARIANCE (1957) (58)
The Value of Transgenic Models for the Study of Neurodegenerative Diseases (2000) (56)
Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F (2010) (55)
Risk avoidance and nesting strategies (1984) (54)
The evolution of XY females in mammals (1981) (54)
The tubulins: From DNA to RNA to protein and back again (1983) (54)
Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points (2017) (54)
The Significance of Protandry in Social Hymenoptera (1983) (53)
DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres (2019) (53)
Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression (1986) (53)
The AAA+ ATPase TRIP13 remodels HORMA domains through N‐terminal engagement and unfolding (2017) (52)
Motor neurone disease and animal models (1994) (52)
Phosphorylation of Highly Conserved Neurofilament Medium KSP Repeats Is Not Required for Myelin-Dependent Radial Axonal Growth (2009) (52)
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis (2019) (52)
Longevity enhances selection of environmental sex determination (1989) (51)
Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1 (2008) (51)
Toxicity of ALS-linked SOD1 mutants. (2000) (51)
Neuronal intermediate filaments: new progress on an an old subject (1994) (51)
Worker-queen conflict in annual social hymenoptera (1981) (50)
Francis Galton: Pioneer of Heredity and Biometry (2003) (49)
Aneuploidy Drives a Mutator Phenotype in Cancer (2011) (49)
The sib competition model for the maintenance of sex and recombination. (1980) (49)
Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. (1990) (49)
Treating Neurodegenerative Diseases with Antibiotics (2005) (48)
Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway. (2009) (48)
The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. (1987) (48)
Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. (1988) (48)
Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. (1981) (47)
Epidermal development, growth control, and homeostasis in the face of centrosome amplification (2015) (47)
Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. (2018) (46)
Neuronal Growth and Death: Order and Disorder in the Axoplasm (1996) (46)
CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. (2017) (46)
Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype (1985) (45)
A survey of the alpha‐tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. (1988) (45)
A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine (1987) (45)
Rethinking Unconventional Translation in Neurodegeneration (2017) (45)
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis (2017) (45)
Sequence of chicken cβ7 tubulin: Analysis of a complete set of vertebrate β-tubulin isotypes (1988) (44)
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis (2012) (44)
Causes and consequences of micronuclei. (2021) (43)
Involvement of neurofilaments in motor neuron disease (1993) (42)
Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. (2016) (42)
Estimating the variability of substitution rates. (1989) (42)
Slow axonal transport models come full circle: Evidence that microtubule sliding mediates axon elongation and tubulin transport (1991) (41)
A statistical analysis of nucleotide sequences of introns and exons in human genes. (1987) (41)
Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide (1984) (41)
The theory of prey-predator oscillations. (1976) (40)
In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. (2006) (40)
Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients (2018) (40)
Polo-like kinase 4 inhibition: a strategy for cancer therapy? (2014) (39)
Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors (2015) (39)
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant (2013) (38)
Centromere identity, function, and epigenetic propagation across cell divisions. (2010) (38)
Sex ratio theory in social insects with swarming (1983) (38)
Gene regulation through messenger RNA stability. (1989) (38)
Galton's law of ancestral heredity (1998) (38)
Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis (2006) (38)
Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease. (1996) (37)
Does aneuploidy cause cancer? [Current Opinion in Cell Biology 2006, 18:658–667] (2007) (37)
Gene therapy for ALS delivers (2004) (36)
Neurodegeneration: An expansion in ALS genetics (2010) (36)
Treadmilling of tubulin and actin (1982) (36)
BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules (2019) (35)
Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. (2012) (35)
Antisense Drugs Make Sense for Neurological Diseases. (2020) (35)
Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling (2014) (34)
Physical Evidence forCotranslational Regulation of 3-Tubulin mRNA Degradation (1992) (34)
Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation. (2001) (34)
Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. (1986) (34)
Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype (2021) (33)
TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC (2018) (33)
Kinetochore–microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E (2014) (33)
Did Jenkin's swamping argument invalidate Darwin's theory of natural selection? (2004) (32)
Sex determination in fish (1987) (32)
The Development of Francis Galton's Ideas on the Mechanism of Heredity (1999) (31)
Bcl-2 Overexpression Does Not Protect Neurons from Mutant Neurofilament-Mediated Motor Neuron Degeneration (1999) (31)
Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. (1993) (31)
Worker-queen conflict and sex ratio theory in social hymenoptera (1981) (30)
The stability of equilibria under selection (1971) (30)
Some Importin News About Spindle Assembly (2001) (29)
Stable equilibria under the two-island model (1971) (29)
Geographical Uniformity of Protein Polymorphisms (1973) (28)
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. (1981) (28)
VEGF: multitasking in ALS (2005) (28)
Transient genomic instability drives tumorigenesis through accelerated clonal evolution (2020) (28)
RNA polymerase specificity of mRNA production and enhancer action. (1986) (26)
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs (2016) (26)
Cytoskeletal linkers: New MAPs for old destinations (1999) (25)
Low Rates of Aneuploidy Promote Tumorigenesis while High Rates of Aneuploidy Cause Cell Death and Tumor Suppression (2008) (25)
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) (25)
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. (2012) (25)
Centriole duplication (2010) (25)
Motor neuron disease: The curious ways of ALS (2008) (24)
Sex ratios in geographically structured populations. (1986) (24)
Hypoxia and Lou Gehrig (2001) (23)
Comment on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint" (2007) (22)
Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. (1987) (22)
Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. (1987) (21)
Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. (2017) (21)
Cyclical parthenogenesis and the cost of sex (1982) (20)
Gene therapy: Gene-editing therapy for neurological disease (2017) (20)
Protein Polymorphism (1971) (20)
Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. (1982) (20)
Neuronal and glial cytoskeletons (1991) (19)
Strand symmetry of mutation rates in theβ-globin region (1991) (19)
Reconstruction of Tubulin Gene Regulation in Cultured Mammalian Cells a (1986) (19)
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. (2019) (19)
22 Translationally Coupled Degradation of mRNA in Eukaryotes (1996) (18)
Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition (2021) (18)
Macrophage Migration Inh ibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD 1 (2015) (18)
In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. (1990) (18)
Phosphorylation of CENP-A on serine 7 does not control centromere function (2019) (18)
Sex ratio evolution in lemmings (1988) (17)
Immune evasion in HPV− head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss (2021) (17)
A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. (1987) (17)
The theory of natural selection of Alfred Russel Wallace FRS (2005) (17)
Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. (1978) (17)
Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. (1983) (17)
Beyond Nuclear Transport (1999) (17)
Sexual differentiation in the phase of the circadian rhythm of (35S) methionine incorporation into cerebral proteins, and of serum gonadotrophin levels. (1974) (17)
Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes (1985) (16)
Cell cycle. Some importin news about spindle assembly. (2001) (16)
Sequence and Expression of the Chicken r5- and 14-Tubulin Genes Define a Pair of Divergent 1-Tubulins with Complementary Patterns of Expression (16)
Sequence of a Highly Divergent h ' Tubulin Gene Reveals Regional Heterogeneity in the / 3 Tubulin Polypeptide (1984) (16)
Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72 (2016) (16)
Proceedings of the 2nd international conference on quantitative genetics: edited by Bruce S. Weir, Eugene J. Eisen, Major M. Goodman and Gene Namkoong, Sinauer Associates, 1988, $38.50 (pbk), $60.00 (cloth) (xii + 724 pages) ISBN 0 87893 901 6 (1989) (15)
Sex Ratio Evolution in Social Hymenoptera Under Worker Control with Behavioral Dominance (1983) (15)
GENETIC MODELS OF ENDOSPERM EVOLUTION IN HIGHER PLANTS (1986) (14)
Has gene therapy for ALS arrived? (2003) (14)
Disrupted nuclear import-export in neurodegeneration (2016) (14)
Surprising S1-resistant trimolecular hybrids: potential complication in interpretation of S1 mapping analyses (1985) (14)
Survival and anisogamy (2002) (13)
Neurofilaments: Organization and Function in Neurons (2009) (13)
Music from fractal noise (2000) (13)
Tubulin site interpretation (1990) (13)
Codon usage and secondary structure of MS2 phage RNA. (1989) (12)
Medicine. Treating neurodegenerative diseases with antibiotics. (2005) (12)
Beyond genetics: surprising determinants of cell fate in antitumor drugs. (2008) (12)
C 9 ORF 72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF 2 α phosphorylation (2018) (12)
10 – Translationally Coupled Degradation of Tubulin mRNA (1993) (12)
RCADiA: simple automation platform for comparative multidimensional protein identification technology. (2007) (12)
Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. (2018) (12)
Molecular Mechanisms Controlling Tubulin Synthesis (1986) (12)
Query: Sire Evaluation with Best Linear Unbiased Predictors (1982) (12)
MORTALITY IN THE GREAT TIT PARUS MAJOR (2008) (12)
A reference induced pluripotent stem cell line for large-scale collaborative studies (2021) (12)
Gain of Toxicity from ALS / F TD-Linked Repeat Expansions in C 9 ORF 72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs Highlights (2016) (11)
An Amino-Terminal Tetrapeptide Specifies Cotranslational Degradation of 3-Tubulin but Not oL-Tubulin mRNAs (11)
Determinants of rapid disease progression in ALS (2005) (10)
How to Survive Aneuploidy (2010) (10)
Interrogating cell division errors using random and chromosome-specific missegregation approaches (2017) (10)
Excitotoxicity hypothesis. Discussion (1996) (10)
A reference human induced pluripotent stem cell line for large-scale collaborative studies. (2022) (10)
Noise and the Visual Threshold (1957) (9)
Strand symmetry of mutation rates in the beta-globin region. (1991) (9)
Population and Community Ecology. Principles and Methods (1976) (9)
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1 (2018) (9)
Expression ofHumanoc-Tubulin Genes: Interspecies Conservation of3'Untranslated Regions (1983) (9)
Microtubule MAPping (1990) (7)
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation (2012) (7)
Stable equilibria under the migration matrix model (1971) (7)
Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. (1988) (7)
DNA replication-mediated error correction of ectopic CENP-A deposition maintains centromere identity (2018) (7)
Intercellular miscommunication in polyglutamine pathogenesis (2006) (7)
CENP-A and the CENP nomenclature: response to Talbert and Henikoff. (2013) (7)
CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila (2000) (6)
Motor neuron disease and model systems: aetiologies, mechanisms and therapies. (1996) (6)
CONFIDENCE INTERVALS FOR DISTANCE IN THE ANALYSIS OF VARIANCE (1958) (6)
Commentary: Francis Galton and the twin method. (2012) (6)
Four unique genes required for beta tubulin expression in vertebrates. (1983) (6)
Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice (2013) (6)
Use of DNA transfection to analyze gene regulation and function in animal cells: dissection of the tubulin multigene family. (1989) (6)
Autoregulatory control of expression of alpha and beta tubulin. (1983) (6)
The maintenance of the genetic variability of polygenic characters by heterozygous advantage. (1974) (6)
A critique of directionality theory (2006) (6)
TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli (2020) (6)
Neurodegenerative diseases and model systems. (1996) (5)
Amyotrophic lateral sclerosis and gene therapy (2006) (5)
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation (2020) (4)
A model for character displacement based on competition between species (1974) (4)
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis (2021) (4)
Why do they do it? (1988) (4)
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS (2020) (4)
Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies (2023) (4)
Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis (2021) (4)
Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer (2021) (4)
Post-transcriptional processes. (1992) (3)
Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration : Induction of a specific 8-tubulin isotype ( cDNA / mRNA / cytoskeleton / microtubule ) (3)
TDP-43 toxicity and the usefulness of junk (2012) (3)
Gene expression regulated by RNA stability (2020) (3)
The maintenance of heterozygosity under the diffusion model. (1974) (3)
Author Correction: Reversing a model of Parkinson’s disease with in situ converted nigral neurons (2020) (3)
Microtubule capture by CENP-E silences mitotic checkpoint signaling (2004) (3)
Neurofilaments and Motor Neuron Disease (1995) (3)
Mitochondrial Isolation and Purification from Mouse Spinal Cord. (2013) (3)
Transgenic and gene-targeting approaches to model disorders of motor neurons (1996) (2)
Correction for Bulmer and Parker, The evolution of anisogamy: a game-theoretic approach (2002) (2)
Sequence Variants in Human Neurofilament (1996) (2)
Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response (2018) (2)
Deletion or Inhibition of th e Oxygen Sensor PHD 1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism Graphical (2016) (2)
Mechanisms of selective motor neurons death in transgenic mouse models of motor neuron disease. Discussion (1996) (2)
Reversing a model of Parkinson’s disease with in situ converted nigral neurons (2020) (2)
Mouse Models of Amyotrophic Lateral Sclerosis (1999) (2)
The curious incident of the translational dog that didn't bark. (2015) (2)
Merits of a New Drug Trial for ALS? (2005) (2)
HIGH MOLECULAR WEIGHT NEUROFILAMENT PROTEINS (2001) (2)
Population genetics with age — not forgetting the genes (1981) (2)
Sex ratio theory: theoretical studies in sex ratio evolution. (1986) (2)
Post-transcriptional processes. (1992) (1)
Estimation issues in allometric scaling models (2003) (1)
Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation (1992) (1)
Examination of the Genes Coding for α - and β -Tubulin (1981) (1)
Author response: The quantitative architecture of centromeric chromatin (2014) (1)
GAIN OF AN ADVERSE PROPERTY BY A MUTANT SOD1 ENZYME PRODUCE EXTENSIVE MOTOR NEURON ABNORMALITIES IN TRANSGENIC MICE: 124 (1995) (1)
Evolution: sex determination in fish. (1987) (1)
Therapeutic Reversal of Chemically Induced Parkinson Disease by Converting Astrocytes into Nigral Neurons (2020) (1)
Amyotrophic Lateral Sclerosis (ALS): Disease Mechanisms (2009) (1)
Gene-editing therapy for neurological disease (1)
Mechanisms of Motor Neuron Death in ALS (2001) (1)
'Exploring aneuploidy: the significance of chromosomal imbalance' review series (2012) (1)
Local male competition and the sex ratio. (1980) (1)
Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS (2015) (1)
CHARACTERIZATION OF INTRACYTOPLASMIC ABNORMALITIES IN LOW EXPRESSOR SOD1 TRANSGENIC MICE WITH MOTOR NEURON DISEASE (1996) (1)
13 Short-term Changes in the Variance (2012) (1)
Multiclassifier proteomics to define complexes yields new chromosomal proteins. (2010) (1)
Aneuploidy and chromosomal instability caused by CENP-E heterozygosity contribute to tumorigenicity. (2006) (1)
The histone H3 variant CENP‐A localizes to sites of DNA repair induced by laser microirradiation of living cells (2008) (0)
Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism (2014) (0)
The Journal of Cell Biology: Letter from the editors (1999) (0)
Special Issue on amyotrophic lateral sclerosis (2014) (0)
Biochemical Investigations into the Kinesin-2 Chemomechanical Cycle (2013) (0)
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements (2019) (0)
Kinetochore Kinesin CENP-E Tracks the Tips of Dynamic Microtubules via the ‘Tethered Motor’ Mechanism (2013) (0)
Mitotic Kinesin CENP-E is a Robust Tracker of Dynamic Microtubule ends (2012) (0)
Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats (2023) (0)
CENP-A Is Dispensable fo r Mitotic Centromere Function after Initial Centromere / Kinetochore Assembly Graphical Abstract Highlights (2017) (0)
TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC (2018) (0)
Ferritin synthesis iscontrolled byiron-dependent translational derepression andbychanges insynthesis/transp (1993) (0)
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation (2021) (0)
BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules (2019) (0)
Raoul et al. Neuron 2002 (2014) (0)
Letter From The Editors (1999) (0)
Raoul SOD Fas Neuron 2002 (2014) (0)
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant (2013) (0)
Use of DNA Transfection Regulation and Function Dissection of the Tubulin to Analyze Gene in Animal Cells: Mu It igene Fam i I y (1989) (0)
1011 NF-M is an essential target for the myelin-directed “outside-in” signaling cascade that mediates radial axonal (2003) (0)
Forensic DNA typing. (1992) (0)
Editorial Board (1981) (0)
DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres (2019) (0)
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation (2018) (0)
Bub3 promotes BubR1's checkpoint function through both kinetochore-dependent and kinetochore-independent manners (2013) (0)
Unpolymerized tubulin levels modulate the expression of alpha tubulin and beta tubulin (1982) (0)
MinireviewWaiting for Anaphase : Mad 2 and the Spindle (2000) (0)
centrosome duplication to once per cell cycle The autoregulated instability of Polo-like kinase 4 limits Material Supplemental (2013) (0)
Formation of advanced glycation end‐product‐modified superoxide dismutase‐1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation (2001) (0)
JCB: COMMENT (2009) (0)
Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1 (1997) (0)
Surprising S1-Resistant Trimolecular Hybrids: Potential (2003) (0)
Gene regulation (2017) (0)
Involvement of neurofilaments in the growth of axons (1991) (0)
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration (2019) (0)
Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome (2022) (0)
Development of a molecular therapy for the SOD1 familial variant of ALS (2021) (0)
A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata (1990) (0)
3' untranslated regions. interspecies conservation of alpha-tubulin genes: Expression of human (2013) (0)
The beginnings of slow transport : polymer or oligomer ? (0)
Post-transcriptional processes. (1993) (0)
Defining the Locus The centromere challenges the classic view of a genetic (2003) (0)
Erratum: The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation (Journal of Clinical Investigation (2013) 123:2 (933) DOI: 10.1172/JCI68319) (2013) (0)
Sequence andExpression oftheChicken r5-and14-Tubulin Genes Define aPairofDivergent 1-Tubulins withComplementary Patterns ofExpression (1986) (0)
The quantitative architecture of centromeric chromatin access benefits you. Your story matters (2014) (0)
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease (2022) (0)
Abstract 3302: Antisense oligonucleotide depletion of the mitotic kinesin Eg5 by direct delivery to the brain could be a useful strategy for treating glioma tumors. (2013) (0)
Animal Models of Motor and Sensory Neuron Disease (2009) (0)
Autoregulatory control of f 3-tubulin mRNA stability is linked to translation elongation ( gene expression / RNA degradation ) (0)
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic tips. (2016) (0)
Phosphorylation of CENP-A on serine 7 does not control centromere function (2019) (0)
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation (2022) (0)
Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer (2021) (0)
Polyglutamine-Expanded H untingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport Highlights (2017) (0)
GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells. (2023) (0)
Guarding the Genome: Centromeres, the Mitotic Checkpoint and Tumorigenesis (2007) (0)
Aberrant neurofilaments as causes of motor neuron disease (1996) (0)
Effect of Phosphorylation on Motile Properties of the Mitotic Kinesin-5 Cin8 (2013) (0)
Abstracts of papers presented at the 1984 Meeting on Molecular Biology of the Cytoskeleton, April 25-April 29, 1984 (1981) (0)
CRISPR-Cas 9 Screens Ide ntify the RNA Helicase DDX 3 X as a Repressor of C 9 ORF 72 ( GGGGCC ) n Repeat-Associated Non-AUG Translation Graphical (2019) (0)
Evolution and Animal Breeding: Reviews on Molecular and Quantitative Approaches in Honour of Alan Robertson. Edited by William G. Hill and Trudy F. C. Mackay. Wallingford, Oxon, UK: C.A.B. International. 1989. 313 pages. Cloth £45.00. ISBN 085198 6390. (1990) (0)
A Monoclonal Antibody against the Type I 1 Isotype of @-Tubulin (0)
Sex Ratio Theory. (Book Reviews: Theoretical Studies in Sex Ratio Evolution) (1986) (0)
Maths for Biologists (1969) (0)
Results Transgene Copy Number-dependent Increase in NF-H RNA Levels in NF-H Transgenic Mice (2002) (0)
FIRST-YEAR INDIGO BUNTINGS AND THEORIES OF DELAYED PLUMAGE MATURATION (2003) (0)
Coiled-Coil Stalk of Active Kinesin-Like Protein CENP-E is Stably Folded (2011) (0)
Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease (2022) (0)
Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". (2007) (0)
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS (2019) (0)
Gallon’s Theory of Ancestral Inheritance (2004) (0)
Molecular genetic basis of familial ALS. Discussion (1996) (0)
Molecular evolution of life: Edited by Herrick Baltscheffsky, Hans Jörnvall and Rudolf Rigler. Pp. 375. Cambridge University Press, 1986. £40.00 ($69.50) (1987) (0)
beta-actin genes. transfection of cloned beta-tubulin and actin gene regulation after transient Reconstruction of appropriate tubulin and (2013) (0)
RECENT BOOKS IN PRINT (1996) (0)
A cellular structure: the cytoskeleton. (1986) (0)
Control circuit with a control arrangement mutable structure (1971) (0)
Proceedings of the International Conference on Quantitative Genetics. August 16-21, 1976.Edward Pollak , Oscar Kempthorne , Theodore B. Bailey, Jr. (1978) (0)
The CENP‐A Targeting Domain (CATD) Confers Conformational Rigidity to Centromeric Nucleosomes and Plays an Essential Role at Mitosis (2007) (0)
Targeted DNA damage in specification and maintenance of CENP‐A at centromeres: is it required? (2009) (0)
A Cellular Structure: The Cytoskeleton . An Introductory Survey. M. Schliwa. Springer-Verlag, New York, 1986. xii, 326 pp., illus. $78. Cell Biology Monographs, vol. 13. (1986) (0)
Expedition Inspiration Fund for Breast Cancer Research Meeting 2003 (2003) (0)

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