Edwin G. Krebs

Q: What Schools Are Affiliated With Edwin G. Krebs

Edwin G. Krebs is affiliated with the following schools: Washington University in St. Louis, Fukushima Medical University, University of California, Davis, University of Illinois Urbana-Champaign, University of Washington, Harvard University

Edwin G. Krebs's AcademicInfluence.com Rankings

Edwin G. Krebs

Biology

#149

World Rank

#267

Historical Rank

#93

USA Rank

Biochemistry

#22

World Rank

#30

Historical Rank

#14

USA Rank

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Biology

Why Is Edwin G. Krebs Influential?

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According to Wikipedia, Edwin Gerhard Krebs was an American biochemist. He received the Albert Lasker Award for Basic Medical Research and the Louisa Gross Horwitz Prize of Columbia University in 1989 together with Alfred Gilman and, together with his collaborator Edmond H. Fischer, was awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes.

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Edwin G. Krebs's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The MAPK signaling cascade (1995) (3670)
Phosphorylation-dephosphorylation of enzymes. (1979) (1615)
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. (1991) (1225)
Protein serine/threonine kinases. (1987) (1208)
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. (1968) (1134)
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. (1977) (638)
Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases (1971) (637)
Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases. (1971) (567)
Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. (1997) (510)
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae (1987) (496)
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA (1985) (459)
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. (1993) (449)
Conversion of phosphorylase b to phosphorylase a in muscle extracts. (1955) (448)
The isolation and crystallization of rabbit skeletal muscle phosphorylase b. (1958) (446)
Selective requirement for MAP kinase activation in thymocyte differentiation (1995) (445)
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. (1994) (427)
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. (1975) (416)
Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase. (1977) (405)
Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1 (1998) (395)
PURIFICATION AND PROPERTIES OF RABBIT SKELETAL MUSCLE PHOSPHORYLASE B KINASE. (1964) (393)
The phosphorylase b to a converting enzyme of rabbit skeletal muscle. (1956) (391)
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. (1991) (387)
Association of mitogen-activated protein kinase with the microtubule cytoskeleton. (1995) (380)
[43] Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle (1974) (337)
Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides. (1987) (326)
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. (1997) (325)
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. (1992) (318)
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation (1990) (310)
The regulation of skeletal muscle phosphorylase kinase by Ca2+. (1971) (307)
Regulation of oocyte maturation. (1980) (307)
Protein Kinases* *Support of the National Institutes of Arthritis and Metabolic Diseases, NIH, U. S. Public Health Service (AM 12842), the Muscular Dystrophy Association of America, and the American Heart Association is acknowledged. (1972) (290)
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction (1995) (274)
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. (1991) (271)
Inactivation of glycogen synthetase and activation of phosphorylase kinase by muscle adenosine 3',5'-monophosphate-dependent protein kinases. (1970) (270)
Factors affecting the activity of muscle phosphorylase b kinase. (1959) (269)
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. (1989) (258)
Protein phosphorylation and signal transduction. (1999) (257)
The mitogen-activated protein kinase activator. (1992) (256)
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. (1992) (253)
Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes* (2000) (249)
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. (1999) (249)
Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. (1984) (245)
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. (1990) (244)
p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. (1999) (243)
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. (1989) (237)
Myc oncoproteins are phosphorylated by casein kinase II. (1989) (236)
cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. (1995) (234)
Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. (1985) (231)
p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. (1998) (227)
THE REACTION OF SODIUM BOROHYDRIDE WITH MUSCLE PHOSPHORYLASE1 (1958) (226)
Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells (*) (1995) (219)
Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. (1994) (218)
[49a] Muscle phosphorylase b: x Glucose-1-phosphate+ Gn ⇄ Gn+x + x inorganic phosphate(where Gn designates glycogen containing n glucose residues) (1962) (216)
Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. (1977) (211)
Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. (1986) (207)
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck) (1988) (204)
Activation of casein kinase II in response to insulin and to epidermal growth factor. (1987) (201)
Activation of protein kinase by physiological concentrations of cyclic AMP. (1974) (199)
Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. (1977) (199)
Early effect of progesterone on levels of cyclic adenosine 3':5'-monophosphate in Xenopus oocytes. (1979) (199)
ACTIVATION OF SKELETAL MUSCLE PHOSPHORYLASE B KINASE BY CA. (1964) (192)
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. (1996) (191)
Separation of regulatory and catalytic subunits of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase(s) of rabbit skeletal muscle. (1971) (190)
Catalysis of the Phosphorylase Kinase Activation Reaction (1971) (190)
The muscle phosphorylase b kinase reaction. (1958) (189)
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. (1999) (189)
The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. (1987) (188)
Amino acid sequence of the regulatory subunit of bovine type II adenosine cyclic 3',5'-phosphate dependent protein kinase. (1984) (188)
Activation of skeletal muscle phosphorylase kinase by Ca2+. II. Identification of the kinase activating factor as a proteolytic enzyme. (1968) (179)
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. (1992) (173)
Platelet‐derived Growth Factor (1995) (172)
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase. (1980) (167)
Activation of adipose tissue lipase by skeletal muscle cyclic adenosine 3',5'- monophosphate-stimulated protein kinase. (1970) (165)
The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets. (1997) (163)
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity. (1986) (163)
Substrate specificity of the cyclic AMP-dependent protein kinase. (1975) (160)
EFFECTS OF ELECTRICAL STIMULATION AND EPINEPHRINE ON MUSCLE PHOSPHORYLASE, PHOSPHORYLASE B KINASE, AND ADENOSINE 3',5'-PHOSPHATE. (1965) (159)
Translational activation of the lck proto-oncogene (1988) (154)
The MAP kinase cascade. (1995) (153)
Crystallization and properties of rabbit skeletal muscle phosphofructokinase. (1966) (152)
A synthetic peptide substrate specific for casein kinase II. (1985) (150)
A cyclic 3',5'-amp-stimulated protein kinase from cardiac muscle. (1970) (148)
Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase. (1983) (147)
Protein phosphorylation catalyzed by cyclic AMP-dependent and cyclic GMP-dependent protein kinases. (1980) (146)
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. (1990) (146)
Both Phosphorylation and Caspase-mediated Cleavage Contribute to Regulation of the Ste20-like Protein Kinase Mst1 during CD95/Fas-induced Apoptosis* (2001) (145)
Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase. (1983) (144)
Interrelationships among glycogen phosphorylase isozymes. (1967) (143)
Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. (1997) (143)
Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle. (1999) (143)
Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. (1985) (142)
Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes. (1988) (140)
Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. (1986) (139)
Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2. (1991) (139)
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (1990) (138)
Studies of the subunit structure of rabbit skeletal muscle phosphorylase kinase. (1973) (138)
Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells. (1996) (135)
Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. (1990) (135)
Structure of the site phosphorylated in the phosphorylase b to a reaction. (1959) (135)
A cyclic AMP--stimulated protein kinase in adipose tissue. (1969) (134)
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase. (1976) (134)
Identification of two protease inhibitors from bovine cardiac muscle. (1978) (134)
FURTHER STUDIES ON THE SITE PHOSPHORYLATED IN THE PHOSPHORYLASE B TO A REACTION. (1964) (134)
Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis. (1992) (133)
The phosphorylation of proteins: a major mechanism for biological regulation. Fourteenth Sir Frederick Gowland Hopkins memorial lecture. (1985) (131)
The casein kinase II beta subunit binds to Mos and inhibits Mos activity (1997) (130)
Purification, properties, and substrate specificities of phosphoprotein phosphatase(s) from rabbit liver. (1976) (128)
Properties of crystalline phosphorylase b. (1958) (126)
Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. (1990) (126)
Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. (1994) (125)
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner. (1982) (124)
Phosphorylase activity of skeletal muscle extracts. (1955) (124)
Binding of metabolites by phosphofructokinase. (1967) (121)
Physiochemical properties of rabbit skeletal muscle phosphorylase kinase. (1973) (115)
Specific Interaction between Casein Kinase 2 and the Nucleolar Protein Nopp140* (1997) (112)
A Novel Cytoplasmic Dual Specificity Protein Tyrosine Phosphatase Implicated in Muscle and Neuronal Differentiation (*) (1996) (111)
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. (1982) (108)
Purification and properties of inactive liver phosphorylase. (1966) (106)
Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells. (1990) (106)
Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates. (1984) (106)
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. (1982) (105)
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes. (1983) (105)
Regulation of pp56lck during T‐cell activation: functional implications for the src‐like protein tyrosine kinases. (1987) (105)
Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes (1990) (104)
Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides. (1990) (104)
Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to phosphorylation sites in histone H2B. (1979) (102)
Platelet-derived Growth Factor Stimulates Protein Kinase A through a Mitogen-activated Protein Kinase-dependent Pathway in Human Arterial Smooth Muscle Cells (*) (1996) (101)
Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization. (1988) (97)
Interaction of calmodulin and a calmodulin-binding peptide from myosin light chain kinase: major spectral changes in both occur as the result of complex formation. (1985) (96)
Effect of denaturation on the susceptibility of proteins to enzymic phosphorylation. (1975) (92)
The growth of research on protein phosphorylation. (1994) (91)
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. (1986) (90)
Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle. (1971) (89)
Phosphorylation of the inhibitor component of troponin by phosphorylase kinase. (1972) (89)
The Physical Association of Casein Kinase 2 with Nucleolin* (1996) (89)
Altered Expression of Protein-tyrosine Phosphatase 2C in 293 Cells Affects Protein Tyrosine Phosphorylation and Mitogen-activated Protein Kinase Activation (*) (1995) (89)
Protein Serine/Threonine Kinases of the MAPK Cascade (1995) (89)
Casein kinase II as a potentially important enzyme concerned with signal transduction. (1988) (87)
Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions. (1997) (87)
Covalently bound myristate in a lymphoma tyrosine protein kinase. (1984) (87)
A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta. (1984) (86)
Primary structure of the regulatory subunit of type II cAMP-dependent protein kinase from bovine cardiac muscle. (1982) (86)
Rapid microassay for protein kinase C translocation in Swiss 3T3 cells. (1986) (86)
B. ACTIVATION OF SKELETAL MUSCLE PHOSPHORYLASE (1966) (85)
Induction of casein kinase II during differentiation of 3T3-L1 cells. (1987) (85)
Characterization of a cyclic AMP-binding protein from bakers' yeast. Identification as a regulatory subunit of cyclic AMP-dependent protein kinase. (1980) (84)
A comparison of signaling requirements for apoptosis of human B lymphocytes induced by the B cell receptor and CD95/Fas. (1998) (83)
The mechanism of activation of bovine skeletal muscle protein kinase by adenosine 3':5'-monophosphate. (1980) (83)
Activation of skeletal muscle phosphorylase kinase by adenosine triphosphate and adenosine 3',5'-monophosphate. (1968) (83)
1 The Enzymology of Control by Phosphorylation (1986) (82)
Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. (1985) (77)
Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain. (1987) (77)
Positive Effect of Overexpressed Protein-tyrosine Phosphatase PTP1C on Mitogen-activated Signaling in 293 Cells (*) (1996) (75)
Phosphorylation by guanosine 3':5'-monophosphate-dependent protein kinase of synthetic peptide analogs of a site phosphorylated in histone H2B. (1982) (73)
Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. (1982) (73)
Stoichiometry of cAMP and 1,N6-etheno-cAMP binding to protein kinase. (1980) (73)
Protein phosphorylation and cellular regulation I (1993) (72)
Regulation of casein kinase II by growth factors: a reevaluation. (1994) (72)
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. (1974) (72)
The action of glyceraldehyde-3-phosphate dehydrogenase on reduced diphosphopyridine nucleotide. (1954) (70)
Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate. (1986) (70)
The Albert Lasker Medical Awards. Role of the cyclic AMP-dependent protein kinase in signal transduction. (1989) (70)
Adenosine 3',5'-monophosphate-dependent protein kinase from adipose tissue. (1972) (70)
Antibodies to a defined region of pp60src neutralize the tyrosine-specific kinase activity. (1983) (70)
Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells. (1995) (69)
Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase. (1985) (69)
Historical perspectives on protein phosphorylation and a classification system for protein kinases. (1983) (69)
Stimulation of protein phosphatase activity by insulin and growth factors in 3T3 cells. (1988) (68)
Amino acid sequence of rabbit skeletal muscle myosin light chain kinase. (1986) (67)
Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase. (1985) (67)
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein (2002) (67)
Synthetic phosphopeptides are substrates for casein kinase II (1990) (66)
A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. (1983) (65)
STUDIES ON PHOSPHORYLASE ACTIVATION IN THE HEART. (1965) (65)
Agents that elevate cAMP levels in platelets decrease thrombin binding. (1987) (64)
CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression (2005) (64)
Regulation of Ribosomal S6 Protein Kinase-p90rsk, Glycogen Synthase Kinase 3, and β-Catenin in Early Xenopus Development (1999) (64)
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation. (1997) (63)
THE ASSAY OF ADENOSINE-3' ,5'-PHOSPHATE IN SKELETAL MUSCLE. (1964) (63)
Studies on the phosphorylation and activation of skeletal muscle phosphorylase and phosphorylase kinase in vivo. (1970) (63)
A study on the autoactivation of rabbit muscle phosphorylase kinase. (1976) (62)
Vanadate and molybdate increase tyrosine phosphorylation in a 50-kilodalton protein and stimulate secretion in electropermeabilized platelets. (1989) (61)
PHOSPHORYLASE AND RELATED ENZYMES OF GLYCOGEN METABOLISM. (1964) (59)
[61] Glyceraldehyde-3-phosphate dehydrogenase from yeast: GAP + DPN + P ⇄ 1,3-Diphosphoglycerate + DPNH + H+ (1955) (59)
Yeast glyceraldehyde-3-phosphate dehydrogenase. II. Yeast protein 2. (1953) (58)
Characterization of maturation-activated histone H1 and ribosomal S6 kinases in sea star oocytes. (1987) (57)
Comparative studies on glycogen phosphorylase. IV. Purification and properties of rabbit heart phosphorylase. (1962) (56)
Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. (1993) (55)
Mitogen-activated S6 kinase is stimulated via protein kinase C-dependent and independent pathways in Swiss 3T3 cells. (1987) (55)
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function. (1986) (55)
Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle. (1975) (55)
Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin. (1991) (54)
Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system. (1991) (54)
Purification of rabbit skeletal muscle protein kinase regulatory subunit using cyclic adenosine-3':5'-monophosphate affinity chromatography. (1975) (54)
Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin (1992) (54)
Commentary on 'The Phosphorylase b to a Converting Enzyme of Rabbit Skeletal Muscle". (1989) (54)
Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. (1980) (52)
Expression of the Casein Kinase 2 Subunits in Chinese Hamster Ovary and 3T3 L1 Cells Provides Information on the Role of the Enzyme in Cell Proliferation and the Cell Cycle* (1999) (52)
Specificity studies on muscle phosphorylase phosphatase. (1960) (50)
Phosphorylation and dephosphorylation of glycogen phosphorylase: a prototype for reversible covalent enzyme modification. (1981) (50)
The amino acid sequences of the phosphorylated sites in troponin‐I from rabbit skeletal muscle (1974) (49)
In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase. (1978) (49)
Studies on the adenosine 3',5'-monophosphate-dependent protein kinases of rabbit skeletal muscle. (1972) (49)
Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. (1995) (49)
Molecular properties and transformations of glycogen phosphorylase in animal tissues. (1962) (49)
Amino acid sequence of the phosphorylated site in rabbit liver glycogen phosphorylase. (1970) (48)
The expression of cAMP-dependent protein kinase subunits is differentially regulated during liver regeneration. (1989) (47)
Comparative studies on glycogen phosphorylase. V. The amino acid composition of rabbit and human skeletal muscle phosphorylase. (1963) (47)
The effect of salmine on the activity of phosphorylase. (1954) (45)
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. (1991) (45)
A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src. (1982) (45)
Amino acid sequence around a "hinge" region and its "autophosphorylation" site in bovine Lung cGMP-dependent protein kinase. (1983) (44)
Enzymatic conversion of a reduced diphosphopyridine nucleotide derivative to reduced diphosphopyridine nucleotide. (1956) (44)
Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase. (1986) (44)
A constitutively active holoenzyme form of the cAMP-dependent protein kinase. (1991) (44)
A unique mRNA species for a regulatory subunit of cAMP‐dependent protein kinase is specifically induced in haploid germ cells (1988) (43)
Cyclic AMP-dependent protein kinase I: cyclic nucleotide binding, structural changes, and release of the catalytic subunits. (1981) (43)
Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase. (1993) (43)
[49b] Phosphorylase b kinase from rabbit skeletal muscle: 2 Phosphorylase + b + 4 ATP → Phosphorylase a + 4 ADP (1962) (41)
Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex (1985) (41)
Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase. (1992) (40)
16 Protein Kinases (1973) (40)
Amino acid sequence of a phosphorylation site in skeletal muscle glycogen synthetase. (1977) (40)
Crystallization and properties of human muscle phosphorylases a and b. (1960) (39)
Protein Phosphorylation and Cellular Regulation I (Nobel Lecture) (1993) (39)
CK2, a protein kinase of the next millennium (2004) (38)
Affinity labeling of catalytic subunit of bovine heart muscle cyclic AMP-dependent protein kinase by 5'-p-fluorosulfonylbenzoyladenosine. (1979) (38)
THE INHIBITION OF d-GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE BY SPECIFIC ANTISERUM (1948) (38)
Isolation and properties of a reduced diphosphopyridine nucleotide derivative. (1956) (38)
Yeast Glyceraldehyde-3-phosphate dehydrogenase. I. Electrophoresis of fractions precipitated by nucleic acid. (1953) (37)
Studies on the subunit structure of trypsin-activated phosphorylase kinase. (1973) (37)
[92] Phosphorylase b kinase from rabbit muscle (1966) (37)
Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution. (1988) (37)
Amino acid sequence at the ATP-binding site of cGMP-dependent protein kinase. (1982) (37)
Phosphorylation of skeletal muscle myosin light chain kinase by the catalytic subunit of cAMP‐dependent protein kinase (1982) (37)
Fibroblast growth factor, but not activin, is a potent activator of mitogen-activated protein kinase in Xenopus explants. (1994) (36)
A comparison of phosphorylase isozymes in the rabbit. (1970) (35)
Differential regulation of histone H1 and ribosomal S6 kinases during sea star oocyte maturation. (1987) (34)
Dephosphorylation of the inhibitor component of troponin by phosphorylase phosphatase. (1972) (34)
Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle. (1983) (34)
Reversibility of adenosine 3':5'-monophosphate-dependent protein kinase reactions. (1975) (34)
Amino acid sequence of the beta subunit of bovine lung casein kinase II. (1987) (33)
Binding of adenosine 3',5'-monophosphate dependent protein kinase regulatory subunit to immobilized cyclic nucleotide derivatives. (1976) (33)
Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate. (1978) (33)
Evidence from two transformed cell lines that the phosphorylations of peptide tyrosine and phosphatidylinositol are catalyzed by different proteins. (1985) (32)
Properties of phosphorylase kinase and its control in skeletal muscle. (1968) (31)
Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase. (1984) (31)
p90RSK Is a Serum-stimulated Na+/H+ Exchanger Isoform-1 Kinase (1999) (31)
In vivo response of skeletal muscle glycogen phosphorylase, phosphorylase b kinase and cyclic AMP to epinephrine administration. (1962) (30)
Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase (2005) (29)
Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes (1986) (29)
The amino acid sequence of a hinge region in the regulatory subunit of bovine cardiac muscle cyclic AMP‐dependent protein kinase II (1980) (29)
Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. (1993) (28)
The use of synthetic peptides for defining the specificity of tyrosine protein kinases. (1984) (27)
Studies on the phosphorylation of the type I cAMP-dependent protein kinase. (1980) (27)
Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinase (1990) (27)
Activation of skeletal muscle phosphorylase. (1966) (26)
[10] Preparation and properties of the calmodulin-binding domain of skeletal muscle myosin light chain kinase (1987) (26)
Growth factor-stimulated phosphorylation cascades: activation of growth factor-stimulated MAP kinase. (1992) (26)
Studies on the site in the regulatory subunit of type I cAMP-dependent protein kinase phosphorylated by cGMP-dependent protein kinase. (1981) (25)
Nobel Lecture. Protein phosphorylation and cellular regulation I. (1993) (24)
Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrate. (1983) (24)
Comparative studies on glycogen phosphorylase. II. Immunological studies on rabbit and human skeletal muscle phosphorylase. (1962) (23)
Sequential activation of MAP kinase cascade by angiotensin II in opossum kidney cells. (1995) (23)
Epidermal growth factor stimulates glycogen synthase activity in cultured cells. (1985) (22)
Identification of the tyrosine protein kinase from LSTRA cells by use of site-specific antibodies. (1984) (22)
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes. (1988) (22)
Effect of phosphorylation on the regulatory subunit of the type I cAMP-dependent protein kinase. (1981) (21)
THE ROLE OF METALS IN THE ACTIVATION OF MUSCLE PHOSPHORYLASE (1960) (21)
Cyclic AMP-dependent protein kinases from skeletal muscle and liver. (1972) (20)
Reversal of phosphorylase kinase activation. (1968) (19)
Phosphorylation of hydroxyproline in a synthetic peptide catalyzed by cyclic AMP-dependent protein kinase. (1979) (19)
Effect of proteases on the structure and activity of rabbit skeletal muscle glycogen synthetase (1979) (19)
Interactions between protein kinases and proteases in cellular signaling and regulation. (2000) (19)
Comparative studies on glycogen phosphorylase. III. The phosphorylated site in human muscle phosphorylase alpha. (1962) (19)
Affinity labeling of the ATP binding site of bovine lung cyclic GMP-dependent protein kinase with 5'-p-fluorosulfonylbenzoyladenosine. (1981) (18)
Purification of cyclic nucleotide receptor proteins by cyclic nucleotide affinity chromatography. (1979) (18)
Historical perspectives and new insights involving the MAP kinase cascades. (1997) (17)
Reversibility of phosphorylase kinase reaction. (1977) (17)
Modulation of the stability of rabbit skeletal muscle myosin light chain kinase through the calmodulin-binding domain. (1990) (16)
Metabolic Interconversion of Enzymes 1973 (1974) (16)
Regulation of glycogen synthase activity by growth factors. Relationship between synthase activation and receptor occupancy. (1987) (16)
The receptor protein for cyclic AMP in the control of glycogenolysis. (1970) (16)
THE REGULATION OF MUSCLE METABOLISM AND FUNCTION BY PROTEIN PHOSPHORYLATION (1974) (15)
Phosphorylation of cAMP-dependent protein kinase subunits. (1982) (15)
Purification and regulatory properties of liver phosphorylase kinase. (1980) (15)
Studies on the role of adenosine 3':5'-monophosphate in the activation of liver phosphorylase. (1977) (15)
PYRIDOXAL-5′-PHOSPHATE IN THE STRUCTURE AND FUNCTION OF PHOSPHORYLASE (1963) (14)
Insulin and progesterone activate a common synthetic ribosomal protein S6 peptide kinase in Xenopus oocytes (1988) (13)
Crystallization of rabbit muscle phosphofructokinase (1965) (13)
Mechanisms of catalysis (1990) (13)
Substrate recognition by casein kinase‐II: The role of histidine‐160 (1994) (12)
Insulin regulates serine/threonine phosphorylation in activated human B lymphocytes. (1993) (11)
Protein tyrosine phosphatases: a novel family of enzymes involved in transmembrane signalling. (1990) (11)
Regulation of S6 kinase activity in Madin-Darby canine kidney renal epithelial cells. (1990) (11)
Amino acid sequence of the regulatory subunit of bovine type II cAMP-dependent protein kinase (1984) (11)
Identification of proteins that associate with protein kinase CK2 (2004) (11)
Communication between protein tyrosine and protein serine/threonine phosphorylation. (1990) (10)
Association of calmodulin with peptide analogues of the inhibitory region of the heat-stable protein inhibitor of adenosine cyclic 3',5'-phosphate dependent protein kinase. (1986) (10)
Relationship of structure to function of muscle phosphorylase. (1966) (10)
A study of antigen-antibody reaction rates by light transmission measurements☆ (1955) (9)
Science Over Politics (1999) (8)
Properties of a monoclonal antibody directed to the calmodulin-binding domain of rabbit skeletal muscle myosin light chain kinase. (1987) (8)
Deletion of 11 Amino Acids in p90rsk-mo-1Abolishes Kinase Activity (1999) (8)
An accidental biochemist. (1998) (8)
Tumor promoter enhances mitogenesis by PDGF with little effect on PDGF binding (1986) (7)
Role of Protein Phosphorylation in Growth Factor Signal Transduction (1987) (6)
Classification of protein kinases into messenger-dependent and independent kinases. The regulation of independent kinases. (1988) (6)
Protein phosphorylation and metabolic control. (1975) (6)
A Role for the SHP-2 Tyrosine Phosphatase in Nerve Growth Factor-induced PC12 Cell Differentiation (6)
The phosphorylase b to a converting enzyme of rabbit skeletal muscle. 1956. (1989) (6)
The use of antibody to inhibit a particular step in a multienzyme system. (1951) (6)
Protein Tyrosine Kinase Activity of Hormone and Growth Factor Receptors (1986) (6)
Activation mechanism of rabbit skeletal muscle myosin light chain kinase 5′‐p‐Fluorosulfonylbenzoyl adenosine as a probe of the MgATP‐binding site of the calmodulin‐bound and calmodulin‐free enzyme (1991) (6)
PHOSPHORYLATION DEPHOSPHORYLATIO N OF ENZYMES (1979) (5)
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A 431 cell membranes (5)
Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. (1979) (5)
Phosphorylation and Dephosphorylation of Skeletal Muscle Troponin (1974) (5)
Activation ofProtein KinasebyPhysiological Concentrations ofCyclic AMP (1974) (4)
SPECIFICITY CONSIDERATIONS RELEVANT TO PROTEIN KINASE ACTIVATION AND FUNCTION (1979) (4)
Preparation and properties of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. (1987) (4)
Phosphorylation and Dephosphorylation of the Inhibitory Component of Troponin (1973) (4)
Affinity labeling of the nucleotide-binding site of myosin light chain kinases. (1987) (4)
Activation of rabbit skeletal muscle myosin light chain kinase by calmodulin--a mechanistic overview. (1989) (4)
[91] Phosphorylase b and a isozyme I from rabbit heart (1966) (3)
The Structure of Phosphorylases (2008) (3)
Nobel laureates' letter to President Bush. (2001) (3)
LINKING OF PROTEIN HORMONE RECEPTORS TO BIOCHEMICAL EVENTS (1986) (3)
Symposium on regulatory mechanisms mediated by protein phosphorylation - dephosphorylation processes: introductory remarks. (1982) (2)
Regulation of protein serine/threonine kinases by tyrosine kinases. (1993) (2)
[16] Use of 1,N6-Etheno-cAMP as a fluorescent probe to study cAMP-dependent protein kinase (1983) (2)
The preparation and properties of crystalline yeast aldolase. (1962) (2)
Intracellular signal transduction (1996) (2)
Erratum: Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues (Proc. Natl. Acad. Sci. USA (June 1, 1993) 90 (5143-5147)) (1993) (2)
Synthesis and use of 8-azidoguanosine 3 ' , 5 '-cyclic monophosphate as a photoaffinity label for cyclic GMP-dependent protein kinase ( cGMP analog / photolysis / bovine lung ) (1)
ORGANIZATION OF MYOSIN LIGHT CHAIN KINASE FROM RABBIT SKELETAL MUSCLE (1987) (1)
[45] DPNH synthesis from DPNH-X: DPNH-X + ++DPNH + ADP + P + H2O (1963) (1)
Structural requirements for activity of the heat-stable inhibitor of the cAMP-dependent protein kinase (1985) (1)
Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes (1985) (1)
D-glyceraldehyde 3-phosphate dehydrogenase activity of yeast protein No. 2. (1950) (1)
Stimulation of protein phosphatase activity by insulin and growth factors in 3 T 3 cells ( platelet-derived growth factor / epidermal growth (1)
Immunochemical studies on purified d-glyceraldehyde-3-phosphate dehydrogenase from yeast and rabbit muscle. (1948) (1)
Protein phosphorylation : abstracts of papers presented at the Eighth Cold Spring Harbor Conference on Cell Proliferation, September 2-September 7, 1980 (1980) (1)
The Mechanism of Action of Cyclic AMP in the Activation of Phosphorylase Kinase (1972) (1)
Deletion of 11 Amino Acids in p90 rsk-mo-1 Abolishes (1999) (0)
Mechanism of activation and inactivation of the cyclic amp dependent protein kinases (1981) (0)
Fibroblast growth factor treatment ofSwiss3T3cells activates a subunit S6kinase thatphosphorylates asynthetic peptide substrate (1986) (0)
Lymphocytes Gene Expression and Proliferation in B p 38 MAPK Is Required for CD 40-Induced Saklatvala (1998) (0)
PURIFICATION AND PROPERTIES OF RABBIT SKELETAL MUSCLE PHOSPHOFRUCTOKINASE (1965) (0)
Studies on the Regulation of Glycogen and Lipid Metabolism by Insulin and Growth Factors: The Involvement of Receptor Tyrosine Kinase Activation and Casein Kinase II (1989) (0)
O-31: Expression of glycogen synthase kinase-3 mutants in cells and its effect on glycogen synthase activity (2009) (0)
Protein kinases. (1972) (0)
In Memoriam (1963) (0)
Strategies of Sequence Analysis of Regulatory Subunit of Bovine Cardiac Muscle cAMP-Dependent Protein Kinase Type II (1982) (0)
Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle ( protein kinase inhibitor / protein phorphorylation / microsequencing ) (0)
Inhibition of Cyclic Amp Dependent Protein Kinase Ec-2.7.1.37 by Analogs of a Synthetic Peptide Substrate (1978) (0)
Protein Phosphorylation and Cell Regulation. Part 1. (Nobel Lecture) (1993) (0)
Protein Phosphorylation/Vol 8 Books A and B (1981) (0)
des by a tyrosine protein kinase rmphoma cell line (2016) (0)
Platelet-derived growth factor (PDGF) stimulates glycogen synthase activity in 3T3 cells (1986) (0)
Saccharomyces cerevisiae. cyclic AMP-dependent protein kinase in locus encoding a regulatory subunit of the Cloning and characterization of BCY1, a (2012) (0)
Amino acid sequence of the 18 subunit of bovine lung casein kinase II (0)
Use of 1,N6-etheno-cAMP as a fluorescent probe to study cAMP-dependent protein kinase. (1983) (0)
Hormone action. Part F: Protein kinases. (1983) (0)
Pibroblast growth factor, butnotactivin, isapotent activator of mitogen-activated protein kinase inXenopus explants (1994) (0)
Reversible protein phosphorylation as a biological regulatory mechanism (1992) (0)
What's new in the mechanisms of enzyme regulation? (1981) (0)
Interconversion Reactions of Muscle Phosphorylases B and A (2008) (0)
The competitive inhibition of xanthine oxidation by xanthopterin. (1949) (0)
Activation of protein kinases in wild type and phorbol ester resistant el4 thymoma cells (1991) (0)
Mitogen responsive ribosomal s 6 kinase from 3t3 d 1 cells (1986) (0)
Phosphorylation and Dephosphorylation of Skeletal Muscle Troponin 1 (1974) (0)
Characterization of a phorbol ester-stimulated S6 kinase from MDCK renal epithelial cells (1987) (0)
Dedication to Drs. E. G. Krebs and E.H. Fischer (2005) (0)

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