Emily Balskus
#73,530
Most Influential Person Now
American synthetic biologist, chemist, and microbiologist
Emily Balskus's AcademicInfluence.com Rankings
Emily Balskusbiology Degrees
Biology
#6106
World Rank
#8749
Historical Rank
#2008
USA Rank
Evolutionary Biology
#377
World Rank
#404
Historical Rank
#105
USA Rank
Microbiology
#894
World Rank
#983
Historical Rank
#159
USA Rank
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Chemistry Biology
Emily Balskus's Degrees
- PhD Chemistry Stanford University
- Bachelors Chemistry Williams College
Why Is Emily Balskus Influential?
(Suggest an Edit or Addition)According to Wikipedia, Emily P. Balskus is an American chemical biologist, enzymologist, microbiologist, and biochemist born in Cincinnati, Ohio in 1980. She has been on the faculty of the Chemistry and Chemical Biology department of Harvard University since 2011 and is currently the Morris Kahn Professor. She has published more than 80 peer-reviewed papers and three book chapters. Since 2012 she has been invited to give over 170 lectures, has held positions on various editorial boards, and served as a reviewer for ACS and Nature journals among others. Balskus also currently serves as a consultant for Novartis, Kintai Therapeutics, and Merck & Co.
Emily Balskus's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Chemical transformation of xenobiotics by the human gut microbiota (2017) (538)
- Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme (2012) (501)
- Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta (2013) (488)
- Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism (2019) (339)
- The human gut bacterial genotoxin colibactin alkylates DNA (2019) (293)
- The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria (2010) (289)
- Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. (2019) (159)
- Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria (2015) (141)
- A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity. (2013) (138)
- Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption. (2017) (123)
- Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin. (2008) (122)
- Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics (2014) (120)
- Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level (2020) (117)
- α,β-Unsaturated β-Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)-Lactacystin and the Discovery of a New Proteasome Inhibitor (2006) (112)
- A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline (2017) (106)
- Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes. (2014) (98)
- Exploring and Understanding the Biochemical Diversity of the Human Microbiota. (2016) (97)
- A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia (2019) (96)
- Spin-transition behaviour in chains of FeII bridged by 4-substituted 1,2,4-triazoles carrying alkyl tails (2001) (92)
- Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis. (2017) (84)
- An enzymatic cyclopentyl[b]indole formation involved in scytonemin biosynthesis. (2009) (76)
- Asymmetric Catalysis of the Transannular Diels-Alder Reaction (2007) (74)
- Colibactin: understanding an elusive gut bacterial genotoxin. (2015) (73)
- Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins (2018) (72)
- An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin (2018) (72)
- Synthesis of the thapsigargins. (2004) (65)
- The biosynthesis of cyanobacterial sunscreen scytonemin in intertidal microbial mat communities. (2011) (65)
- Opportunities for merging chemical and biological synthesis. (2014) (63)
- Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center. (2012) (56)
- Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity. (2015) (55)
- A biocompatible alkene hydrogenation merges organic synthesis with microbial metabolism. (2014) (54)
- Natural product discovery from the human microbiome (2017) (54)
- Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase. (2016) (52)
- Interfacing microbial styrene production with a biocompatible cyclopropanation reaction. (2015) (52)
- Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry. (2016) (51)
- Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin. (2016) (51)
- Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. (2014) (49)
- Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline (2018) (49)
- A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis. (2017) (49)
- Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin (2018) (42)
- Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B. (2007) (42)
- Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring (2017) (42)
- A sequential tetra-n-propylammonium perruthenate (TPAP)–Wittig oxidation olefination protocol (2003) (40)
- Metabolic functions of the human gut microbiota: the role of metalloenzymes (2018) (39)
- Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria. (2015) (38)
- Structural analysis of spiro beta-lactone proteasome inhibitors. (2008) (35)
- The Human Microbiota, Infectious Disease, and Global Health: Challenges and Opportunities. (2018) (35)
- Discovery of a Diazo-Forming Enzyme in Cremeomycin Biosynthesis. (2018) (34)
- Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. (2018) (33)
- Intercalation of Multiple Carbon Atoms between the Carbonyls of α-Diketones (2001) (31)
- The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity (2019) (30)
- A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria. (2020) (30)
- Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity (2018) (27)
- Biocatalytic Friedel-Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme. (2019) (27)
- The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation (2015) (26)
- Total synthesis of (-)-hennoxazole A. (2007) (26)
- Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties. (2006) (26)
- The bacterial toxin colibactin triggers prophage induction (2022) (25)
- Rescuing auxotrophic microorganisms with nonenzymatic chemistry. (2013) (24)
- Lomaiviticin biosynthesis employs a new strategy for starter unit generation. (2014) (24)
- Characterization of 1,2-Propanediol Dehydratases Reveals Distinct Mechanisms for B12-Dependent and Glycyl Radical Enzymes. (2018) (24)
- A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF. (2020) (22)
- A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols (2019) (22)
- Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF (2020) (21)
- Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols (2019) (20)
- Using non-enzymatic chemistry to influence microbial metabolism. (2015) (20)
- Production of Stealthin C Involves an S-N-Type Smiles Rearrangement. (2017) (18)
- Total synthesis of (-)-hennoxazole A. (2007) (17)
- Engineering chemical interactions in microbial communities. (2018) (17)
- The l‐Alanosine Gene Cluster Encodes a Pathway for Diazeniumdiolate Biosynthesis (2020) (16)
- Assembly line termination in cylindrocyclophane biosynthesis : (2015) (16)
- Deciphering Human Gut Microbiota-Nutrient Interactions: A Role for Biochemistry. (2018) (15)
- Illuminating the microbiome’s dark matter: a functional genomic toolkit for the study of human gut Actinobacteria (2018) (15)
- Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation (2022) (14)
- Elucidation of an anaerobic pathway for metabolism of l-carnitine–derived γ-butyrobetaine to trimethylamine in human gut bacteria (2021) (13)
- Deciphering Human Microbiota–Host Chemical Interactions (2020) (11)
- Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. (2020) (11)
- The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk. (2016) (11)
- Discovery of small molecule protease inhibitors by investigating a widespread human gut bacterial biosynthetic pathway (2018) (9)
- Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme (2020) (9)
- Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase (2021) (9)
- Elucidation of an anaerobic pathway for metabolism of L-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteria (2021) (9)
- Discovering radical-dependent enzymes in the human gut microbiota. (2018) (9)
- In vitro characterization of the colibactin-activating peptidase ClbP enables development of a fluorogenic activity probe (2019) (9)
- Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics. (2021) (8)
- Characterization of vaginal microbial enzymes identifies amylopullulanases that support growth of Lactobacillus crispatus on glycogen (2021) (7)
- The L-alanosine gene cluster encodes a pathway for diazeniumdiolate biosynthesis (2019) (6)
- The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia (2022) (6)
- Using Chemical Knowledge to Uncover New Biological Function: Discovery of the Cylindrocyclophane Biosynthetic Pathway (2013) (6)
- A small molecule inhibitor prevents gut bacterial genotoxin production (2022) (5)
- Cysteine dependence in Lactobacillus iners constitutes a novel therapeutic target to modify the vaginal microbiota (2021) (5)
- Structural basis of colibactin activation by the ClbP peptidase (2022) (5)
- Shedding light on sunscreen biosynthesis in zebrafish (2015) (5)
- Leveraging Microbial Genomes and Genomic Context for Chemical Discovery (2021) (5)
- Purification and Characterization of the Choline Trimethylamine-Lyase (CutC)-Activating Protein CutD. (2018) (5)
- The Human Microbiome. (2018) (4)
- Natural products: Sponge symbionts play defense. (2014) (4)
- Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria (2021) (4)
- Correction to Characterization of Choline Trimethylamine-Lyase Expands the Chemistry of Glycyl Radical Enzymes. (2016) (4)
- Correction to Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity. (2015) (4)
- Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis (2021) (3)
- Biocatalytic Friedel–Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme (2019) (3)
- Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily. (2022) (3)
- Discovery of C—C bond-forming and bond-breaking radical enzymes: enabling transformations for metabolic engineering (2020) (3)
- Structural Analysis of Spiro β-Lactone Proteasome Inhibitors (2008) (3)
- SYNTHETIC STUDIES TOWARD HENNOXAZOLE A. USE OF A SELECTIVE BISOXAZOLE ALKYLATION AS THE KEY FRAGMENT COUPLING (2002) (3)
- Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor. (2006) (3)
- The mysteries of macrocyclic colibactins (2019) (3)
- A Sequential Tetra‐n‐propylammonium Perruthenate (TPAP)—Wittig Oxidation Olefination Protocol. (2004) (2)
- Biosynthesis of the Unusual Carbon Skeleton of Nocuolin A (2022) (2)
- Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease (2023) (2)
- Characterization of a cardiac drug‐inactivating enzyme from the prominent human gut microbe, Eggerthella lenta (2017) (2)
- Gut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and Inflammation. (2018) (2)
- Enzymes that detoxify marine toxins (2019) (1)
- Chemical signaling at the eukaryotic/prokaryotic interface. (2018) (1)
- Addressing Infectious Disease Challenges by Investigating Microbiomes. (2016) (1)
- α,β‐Unsaturated β‐Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)‐Lactacystin and the Discovery of a New Proteasome Inhibitor. (2006) (1)
- The gut bacterial natural product colibactin triggers induction of latent viruses in diverse bacteria (2021) (1)
- Synthesis of Bengazole A (2007) (1)
- Synthesis of (-)-Hennoxazole A (2008) (1)
- Molecular Basis of C–S Bond Cleavage in the Glycyl Radical Enzyme Isethionate Sulfite-Lyase (2020) (0)
- The Royal Society of tivity and biosynthesis of cyanobacterial alkylresorcinols (2019) (0)
- Radical Chemistry in the Human Gut: Discovery of Choline Trimethylamine‐Lyase (2015) (0)
- Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin (2008) (0)
- Crystal structure of yeast 20S proteasome in complex with spirolactacystin (2008) (0)
- Abstract IA21: Deciphering the human gut microbiome with chemistry (2020) (0)
- 1207. Combining standard bacterial vaginosis treatment with cystine uptake inhibitors to block growth of Lactobacillus iners is a potential a target for shifting the cervicovaginal microbiota towards health-associated Lactobacillus crispatus-dominant communities (2020) (0)
- Identification and characterization of bacterial glycogen-degrading enzymes in the vaginal microbiome (2023) (0)
- An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin (2019) (0)
- Back Cover: The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation (ChemBioChem 15/2015). (2015) (0)
- Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators (2022) (0)
- Interfacing Biocompatible Reactions with Engineered Escherichia coli. (2017) (0)
- Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A (Ia) and B (Ib). (2007) (0)
- Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin (2018) (0)
- Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile (2022) (0)
- Exceptional Convergence on the Macroevolutionary Landscape in Island Lizard Radiations (2013) (0)
- Intercalation of Multiple Carbon Atoms Between the Carbonyls of α-Diketones. (2010) (0)
- Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline (2018) (0)
- Lactobacillus iners growth inhibition by cystine uptake inhibitors is a target for shifting cervicovaginal microbiota towards lactobacillus crispatus-dominant communities (2020) (0)
- Science Journals — AAAS (2017) (0)
- GUT MICROBIAL METABOLISM OF 5-ASA IS PROSPECTIVELY ASSOCIATED WITH TREATMENT FAILURE IN PATIENTS WITH IBD (2023) (0)
- Rhodium-Catalyzed Coupling of Heterocycles and Alkenes: A Novel Mechanism of C—H Activation (2004) (0)
- Translating Microbiome Research into Therapies: The Path Ahead (2020) (0)
- Development and Validation of a Metabolomic Pipeline to Identify Novel Diagnostic and Therapeutic Targets in Antibiotic Resistant Bacterial Infections (2023) (0)
- Anaerobic 4‐Hydroxyproline Metabolism by a Widespread Microbial Glycyl Radical Enzyme (2018) (0)
- Transannular Diels-Alder Reaction Catalyzed by Chiral Oxazaborolidine (2007) (0)
- Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria (2021) (0)
- Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer (2022) (0)
- In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Design of a Fluorogenic Activity Probe. (2019) (0)
- Intercalation of multiple carbon atoms between the carbonyls of alpha-diketones. (2001) (0)
- Chemical discovery in the microbial world (2014) (0)
- Targeting the human gut microbiome with small-molecule inhibitors. (2023) (0)
- Complete integration of carbene-transfer chemistry into biosynthesis. (2023) (0)
- Lizard Radiations Exceptional Convergence on the Macroevolutionary Landscape in (2013) (0)
- Announcement of 2019 Keystone Symposia Conference: “Microbiome: Chemical Mechanisms and Biological Consequences” (2018) (0)
- 549: GUT MICROBIAL METABOLISM OF 5-ASA DIMINISHES ITS CLINICAL EFFICACY IN IBD (2022) (0)
- Rescuing Auxotrophic Microorganisms with Nonenzymatic (2015) (0)
- Synthesis of (+)-Lactacystin (2006) (0)
- Asymmetric Catalysis of the Transannular Diels—Alder Reaction. (2008) (0)
- Elucidating the Chemistry and Biology of the Human Microbiome. (2022) (0)
- Abstract 19174: Gut Microbial Utilization of Choline Significantly Alters Host Lipid, DNA Methylation, and Hepatic Gene Expression Profiles (2016) (0)
- The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia (2021) (0)
- Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. (2016) (0)
- Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation (2022) (0)
- Abstract IA20: Novel cell microarray technologies for studies of DNA damage and cell survival and applications for studies of microbe-induced DNA damage (2020) (0)
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