George Kollias
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Greek immunologist
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George Kollias biology Degrees
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Biology
George Kollias 's Degrees
- Masters Immunology University of Crete
Why Is George Kollias Influential?
(Suggest an Edit or Addition)According to Wikipedia, George Kollias is a Greek biologist, Member of the Academy of Athens and Professor of Physiology at the Medical School of the National and Kapodistrian University of Athens. He is renowned for providing the preclinical rationale for the development of anti-TNF therapies for rheumatoid arthritis. His research is highly cited for discovering disease pathways in animal models of chronic inflammation and autoimmunity . He is credited with the development of major national infrastructures of scientific and technological excellence in Greece.
George Kollias 's Published Works
Published Works
- The Transcriptional Landscape of the Mammalian Genome (2005) (3394)
- Position-independent, high-level expression of the human β-globin gene in transgenic mice (1987) (1776)
- Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. (1991) (1590)
- Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia (2006) (1516)
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. (1999) (1391)
- The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor (1995) (1374)
- Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response (1996) (1234)
- CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity (2001) (981)
- TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway (2000) (749)
- Interleukin 6 Is Required for the Development of Collagen-induced Arthritis (1998) (641)
- Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. (1995) (586)
- Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis (1999) (550)
- Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice (1997) (425)
- MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels* (2002) (423)
- Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2 (2000) (420)
- Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. (1999) (417)
- Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. (1995) (409)
- TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. (2000) (381)
- Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level (2001) (372)
- Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. (2008) (369)
- Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. (1998) (343)
- Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. (2003) (333)
- Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells (2013) (319)
- Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases (2008) (315)
- Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. (2002) (312)
- Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling (1997) (312)
- Osteoclasts are essential for TNF-alpha-mediated joint destruction. (2002) (300)
- Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice (1997) (300)
- Interleukin‐10 targets p38 MAPK to modulate ARE‐dependent TNF mRNA translation and limit intestinal pathology (2001) (296)
- The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. (2009) (292)
- Blockade of TNF-α rapidly inhibits pain responses in the central nervous system (2011) (292)
- Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses (2008) (280)
- On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease (1999) (279)
- Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. (1997) (267)
- Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease (2002) (266)
- Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice (2005) (260)
- HuR as a negative posttranscriptional modulator in inflammation. (2005) (249)
- The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo. (1995) (228)
- Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. (1997) (227)
- Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling (2015) (227)
- Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury. (1997) (216)
- Regulated expression of human A γ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns (1986) (210)
- The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease (1999) (207)
- Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis. (2000) (203)
- Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases (2004) (201)
- In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis (1997) (200)
- Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments. (2002) (188)
- Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis (2010) (186)
- Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production (2009) (185)
- The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice (1995) (177)
- Cellular mechanisms of TNF function in models of inflammation and autoimmunity. (2010) (165)
- DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition. (1997) (163)
- The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells (1998) (158)
- Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis1 (2005) (158)
- RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation (2015) (154)
- Inflammation-induced formation of fat-associated lymphoid clusters (2015) (152)
- TNF-α transgenic and knockout models of CNS inflammation and degeneration (1997) (151)
- A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling (1997) (150)
- Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis. (2004) (142)
- Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis (2012) (139)
- Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. (2000) (134)
- Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche (2020) (134)
- Mesenchymal Cells in Colon Cancer. (2017) (133)
- STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis (2019) (131)
- A Critical Role of the p75 Tumor Necrosis Factor Receptor (p75TNF-R) in Organ Inflammation Independent of TNF, Lymphotoxin α, or the p55TNF-R (1998) (131)
- Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis (2006) (130)
- Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. (2013) (129)
- Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice. (1996) (129)
- Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity (2006) (127)
- Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. (2012) (126)
- Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology (2011) (125)
- FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. (2006) (124)
- Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation. (2019) (123)
- Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation. (2014) (123)
- Heme oxygenase 1 (HO‐1) regulates osteoclastogenesis and bone resorption (2005) (122)
- Fibroblasts as immune regulators in infection, inflammation and cancer (2021) (119)
- Genetic diversity predicts pathogen resistance and cell-mediated immunocompetence in house finches (2005) (119)
- TNF pathophysiology in murine models of chronic inflammation and autoimmunity. (2005) (118)
- The human β-globin gene contains a downstream developmental specific enhancer (1987) (116)
- Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions (2017) (111)
- Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. (1995) (109)
- The mesenchymal context in inflammation, immunity and cancer (2020) (109)
- Dynamics of a novel pathogen in an avian host: Mycoplasmal conjunctivitis in house finches. (2005) (106)
- Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis (2018) (106)
- SEROPREVALENCE OF INFECTIOUS DISEASE AGENTS IN FREE-RANGING FLORIDA PANTHERS (FELIS CONCOLOR CORYI) (1993) (105)
- Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. (2000) (104)
- Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. (2008) (103)
- Animal models for arthritis: innovative tools for prevention and treatment (2011) (100)
- Role of tumour necrosis factor α in experimental arthritis: separate activity of interleukin 1β in chronicity and cartilage destruction (1999) (99)
- Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model (2012) (99)
- Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes. (1993) (95)
- Erratum: Corrigendum: The European dimension for the mouse genome mutagenesis program (2004) (95)
- Ligand-based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks. (2011) (93)
- A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain (2019) (92)
- The role of TNF-α during Wallerian degeneration (2000) (86)
- Tumor necrosis factor‐receptor 2 is up‐regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo (2002) (86)
- IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer (2015) (83)
- Comparative Analysis of Signal Transduction by CD40 and the Epstein-Barr Virus Oncoprotein LMP1 In Vivo (2004) (82)
- EXPERIMENTAL INFECTION OF HOUSE FINCHES WITH MYCOPLASMA GALLISEPTICUM (2004) (80)
- Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice (2003) (79)
- Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model. (2011) (77)
- Loss of downregulated in adenoma (DRA) impairs mucosal HCO3− secretion in murine ileocolonic inflammation (2012) (75)
- Anaemia and resistance to malaria in transgenic mice expressing human tumour necrosis factor. (1994) (74)
- Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression (1999) (74)
- Neurobehavioral Alterations in Developing Transgenic Mice Expressing TNF-α in the Brain (1996) (73)
- Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. (2010) (73)
- The α-Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss1 (2009) (72)
- Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. (1999) (71)
- Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. (2012) (69)
- MYCOPLASMAL CONJUNCTIVITIS IN SONGBIRDS FROM NEW YORK (2000) (69)
- TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. (1997) (68)
- Tumor necrosis factor biology in experimental and clinical arthritis (2003) (67)
- Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression (2016) (66)
- Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis (2014) (64)
- The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor. (1993) (61)
- The maintenance of methylation-free islands in transgenic mice. (1986) (61)
- HOST RANGE AND DYNAMICS OF MYCOPLASMAL CONJUNCTIVITIS AMONG BIRDS IN NORTH AMERICA (2001) (60)
- Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function (1998) (60)
- Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma (2019) (60)
- Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. (2013) (59)
- Cutting Edge: Antilisterial Activity of CD8+ T Cells Derived from TNF-Deficient and TNF/Perforin Double-Deficient Mice1 (2000) (58)
- Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols (2003) (58)
- Cytoskeletal Rearrangements in Synovial Fibroblasts as a Novel Pathophysiological Determinant of Modeled Rheumatoid Arthritis (2005) (58)
- Differential regulation of a Thy-1 gene in transgenic mice. (1987) (57)
- INFECTIOUS AND PARASITIC DISEASES AND CONTAMINANT-RELATED PROBLEMS OF NORTH AMERICAN RIVER OTTERS (LONTRA CANADENSIS): A REVIEW (2009) (57)
- Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. (2009) (57)
- DYNAMICS OF CONJUNCTIVITIS AND MYCOPLASMA GALLISEPTICUM INFECTIONS IN HOUSE FINCHES (2001) (56)
- Characterization of Experimental Mycoplasma gallisepticum Infection in Captive House Finch Flocks (2006) (56)
- Molecular Modeling on Pyrimidine-Urea Inhibitors of TNF-α Production: An Integrated Approach Using a Combination of Molecular Docking, Classification Techniques, and 3D-QSAR CoMSIA (2012) (56)
- RISK FACTORS ASSOCIATED WITH MYCOPLASMAL CONJUNCTIVITIS IN HOUSE FINCHES (1998) (55)
- Predictive QSAR workflow for the in silico identification and screening of novel HDAC inhibitors (2009) (55)
- The role of TNF-alpha during Wallerian degeneration. (2000) (54)
- A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas. (2009) (53)
- Cutaneous papillomas associated with a herpesvirus-like infection in a herd of captive African elephants. (1986) (53)
- Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance Induction 1 (2009) (52)
- Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction. (1999) (52)
- Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities (1987) (52)
- TNFα-dependent development of lymphoid tissue in the absence of RORγt+ Lymphoid Tissue Inducer cells (2013) (52)
- Exploratory and Displacement Behavior in Transgenic Mice Expressing High Levels of Brain TNF-α (1998) (52)
- The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. (2012) (51)
- Oncogenicity of gibbon type‐C myelogenous leukemia virus (1980) (51)
- Dissection of the pathologies induced by transmembrane and wild‐type tumor necrosis factor in transgenic mice (1996) (51)
- A standardized protocol for the isolation and culture of normal and arthritogenic murine synovial fibroblasts (2009) (51)
- In Silico Exploration for Identifying Structure–Activity Relationship of MEK Inhibition and Oral Bioavailability for Isothiazole Derivatives (2010) (51)
- Tumour necrosis factors in immune regulation: everything that's interesting is...new! (1996) (50)
- Inhibition of Tumor Necrosis Factor mRNA Translation by a Rationally Designed Immunomodulatory Peptide* (2000) (49)
- Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line? (2000) (49)
- A combined LS-SVM & MLR QSAR workflow for predicting the inhibition of CXCR3 receptor by quinazolinone analogs (2010) (49)
- A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. (2012) (49)
- Role of the Innate Immune System in Acute Viral Myocarditis (2009) (48)
- A new generation of high-affinity humanized PEGylated Fab´ fragment anti-tumor necrosis factor-α monoclonal antibodies (2006) (47)
- Invariant natural killer T cells are natural regulators of murine spondylarthritis. (2010) (47)
- TNFR2 on non‐haematopoietic cells is required for Foxp3+ Treg‐cell function and disease suppression in EAE (2012) (46)
- Functional analysis of an arthritogenic synovial fibroblast (2003) (45)
- Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. (2007) (45)
- Feather and beak dystrophy and necrosis in cockatoos: clinicopathologic evaluations. (1986) (45)
- Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II‐restricted antigen processing and origin of exosomes (2008) (44)
- Diagnosis and Treatment of Babesia odocoilei in Captive Reindeer (Rangifer tarandus tarandus) and Recognition of Three Novel Host Species (2009) (43)
- SEROLOGIC SURVEY OF SELECTED VIRAL AGENTS IN RECENTLY CAPTURED WILD NORTH AMERICAN RIVER OTTERS (LONTRA CANADENSIS) (2000) (42)
- Overexpression of tumor necrosis factor causes bilateral sacroiliitis. (2004) (42)
- Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL) (2017) (42)
- The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises. (1990) (41)
- TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models. (2001) (41)
- Evaluation of Oral Itraconazole Administration in Captive Humboldt Penguins (Spheniscus humboldti) (2009) (41)
- A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice (2014) (40)
- RE-EXPOSURE OF CAPTIVE HOUSE FINCHES THAT RECOVERED FROM MYCOPLASMA GALLISEPTICUM INFECTION (2005) (40)
- Aberrant Expression of the Autoantigen Heterogeneous Nuclear Ribonucleoprotein-A2 (RA33) and Spontaneous Formation of Rheumatoid Arthritis-Associated Anti-RA33 Autoantibodies in TNF-α Transgenic Mice1 (2005) (40)
- MK2 regulates the early stages of skin tumor promotion. (2009) (40)
- A tumor necrosis factor‐induced model of human primary demyelinating diseases develops in immunodeficient mice (1999) (39)
- Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. (1986) (39)
- The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies. (2002) (39)
- SURGICAL TECHNIQUE FOR INTRA-ABDOMINAL RADIOTRANSMITTER PLACEMENT IN NORTH AMERICAN RIVER OTTERS (LONTRA CANADENSIS) (2009) (39)
- Insulin‐like growth factor‐I ameliorates demyelination induced by tumor necrosis factor‐α in transgenic mice (2007) (39)
- Comparative cardiopulmonary effects of intramuscularly administered etorphine and carfentanil in goats. (1996) (39)
- Models for financial sustainability of biological databases and resources (2009) (39)
- AN OUTBREAK OF TOXOPLASMOSIS IN WALLAROOS (Macropus robustus) IN A CALIFORNIA ZOO (1977) (38)
- Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis (2007) (38)
- Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice. (2008) (38)
- Tumor necrosis factor‐α regulation of insulin‐like growth factor‐I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice (2003) (38)
- Murine TNF&Dgr;ARE Crohn's disease model displays diminished expression of intestinal Ca2+ transporters (2008) (38)
- Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study (2004) (38)
- Host and microbiota interactions are critical for development of murine Crohn's-like ileitis (2015) (37)
- Epornitic of papova-like virus-associated disease in a psittacine nursery. (1984) (37)
- Maternal immunoglobulin G antibody transfer and development of immunoglobulin G antibody responses in blue and gold macaw (Ara ararauna) chicks. (1996) (36)
- Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy. (2007) (36)
- Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications (2016) (36)
- Serum total IgE levels in a representative sample of a Greek population (1993) (35)
- Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout (2014) (35)
- Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase (2014) (35)
- Development of a brain nucleus involved in song production in zebra finches (Taeniopygia guttata) is disrupted by Aroclor 1248 (2008) (34)
- Adenovirus-like Infection in a Savannah Monitor (1986) (34)
- Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection. (2016) (33)
- Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis. (2016) (33)
- CLINICAL ANATOMY OF THE NORTH AMERICAN RIVER OTTER (LONTRA CANADENSIS) (2009) (33)
- Mustelidae (2014) (33)
- Protective role of membrane tumour necrosis factor in the host’s resistance to mycobacterial infection (2008) (33)
- DIAGNOSIS OF SKELETAL INJURIES IN CHELONIANS USING COMPUTED TOMOGRAPHY (2004) (33)
- EXERTIONAL MYOPATHY IN TRANSLOCATED RIVER OTTERS FROM NEW YORK (1999) (32)
- The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts (2018) (31)
- Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis (2019) (31)
- Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain. (1996) (30)
- Membrane-Bound TNF Induces Protective Immune Responses to M. bovis BCG Infection: Regulation of memTNF and TNF Receptors Comparing Two memTNF Molecules (2012) (30)
- A new role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis. (2011) (29)
- Inferring active regulatory networks from gene expression data using a combination of prior knowledge and enrichment analysis (2016) (29)
- Centering the Classic Maya Kingdom of Sak Tz’i’ (2020) (28)
- Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation. (2021) (27)
- Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities (1988) (27)
- the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (TNF) at the p55 TNF Receptor Level: Implications for Pathogenesis and Therapy of Autoimmune Demyelination (2001) (26)
- Yersinia pseudotuberculosis in a Closed Colony of Egyptian Fruit Bats (Rousettus aegyptiacus) (2009) (26)
- COMPARISON OF SEROLOGIC ASSAYS FOR THE DIAGNOSIS OF TOXOPLASMOSIS IN NONDOMESTIC FELIDS (1991) (26)
- ‘SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models (2021) (26)
- Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis (2019) (26)
- Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling (2008) (26)
- Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness (2001) (25)
- An Essential Role for TNF in Modulating Thresholds for Survival, Activation, and Tolerance of CD8+ T Cells1 (2007) (25)
- Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis (2018) (24)
- Genomic Responses of Mouse Synovial Fibroblasts During Tumor Necrosis Factor–Driven Arthritogenesis Greatly Mimic Those in Human Rheumatoid Arthritis (2017) (24)
- The human beta-globin gene contains a downstream developmental specific enhancer. (1987) (23)
- Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice. (2007) (23)
- Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice. (1993) (23)
- Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity (2021) (22)
- Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis (2018) (22)
- Modeling the function of tumor necrosis factor in immune pathophysiology. (2004) (22)
- Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis (2020) (21)
- Role of TNFa in experimental arthritis: separate activity of IL-1B in chronicity and cartilage destruction. (1999) (21)
- The BACH1–HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration (2019) (21)
- Transgenic models of TNF induced demyelination. (1999) (21)
- Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice (2009) (20)
- Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. (2021) (20)
- Evaluation of comparative cervical tuberculin skin testing in cervids naturally exposed to mycobacteria. (1982) (20)
- ORAL TREATMENT OF AVIAN LEAD INTOXICATION WITH MESO-2,3-DIMERCAPTOSUCCINIC ACID (2003) (19)
- Reproductive impairment in zebra finches (Taeniopygia guttata) (2005) (19)
- The study of gene regulation in transgenic mice. (1992) (19)
- Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy. (2008) (19)
- Integration of Mouse Phenome Data Resources (2008) (19)
- Opposing role of tumor necrosis factor receptor 1 signaling in T cell–mediated hepatitis and bacterial infection in mice (2016) (19)
- Myeloid Takl Acts as a Negative Regulator of the LPS Response and Mediates Resistance to Endotoxemia (2012) (19)
- Murine TNF ARE Crohn ’ s Disease Model Displays Diminished Expression of Intestinal Ca 2 Transporters (2008) (18)
- Survey of parasite control programs used in captive wild ruminants. (1990) (18)
- Rationally Designed Less Toxic SPD‐304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects (2014) (18)
- Cigarette Smoke–Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells (2018) (17)
- RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury (2019) (17)
- Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. (2018) (17)
- Primary malignant fibrous histiocytoma of the kidney: report of a case. (1987) (17)
- The regulation of expression of human beta-globin genes. (1987) (17)
- Field investigation of Mycoplasma gallisepticum infections in house finch (Carpodacus mexicanus) eggs and nestlings. (1999) (17)
- Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD (2010) (16)
- A myelographic technique for avian species. (1997) (16)
- HYPERKALEMIA IN TWO JAGUARS (PANTHERA ONCA) ANESTHETIZED WITH DEXMEDETOMIDINE, KETAMINE, AND ISOFLURANE (2018) (15)
- Isolation of Intestinal Mesenchymal Cells from Adult Mice (2016) (14)
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- Repurposing antipsychotic drug Amisulpride for targeting synovial fibroblast activation in arthritis. (2023) (0)
- Treatment with diacerein suppresses arthritis progression in Tg197 mice (2011) (0)
- Local TNF ligand/receptor signaling induces MS-type plaques in the CNS of transgenic mice (1998) (0)
- Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor (1993) (0)
- Macrophage BACH1, a heme regulated transcriptional repressor, controls HMOX1 and skeletal muscle regeneration (2019) (0)
- THU0026 P62/SQSTM1 links reactive oxygen species formation and obesity to increased tnfalpha-mediated joint destruction via its signalling domains (2013) (0)
- Autoantibodies to the nuclear antigen hnRNP-A2 (RA33) in animal models of rheumatoid arthritis and systemic lupus erythematosus (1997) (0)
- Role of the TNF/LT/receptor system in the development and function of secondary lymphoid organs (1997) (0)
- Inhibition of TNF MRNA translation by an immunomodulatory peptide (2000) (0)
- Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma (2019) (0)
- TNF / Perforin Double-Deficient Mice T Cells Derived from TNF-Deficient and + Cutting Edge : Antilisterial Activity of CD 8 and (2000) (0)
- Anaemiaandresistance tomalaria intransgenic miceexpressing human tumournecrosis factor (1994) (0)
- P088 Characterization of novel humanized IL-17 mouse preclinical platforms for the efficacy evaluation of anti-human IL17 therapeutics (2019) (0)
- Encephalomyelitis Experimental Autoimmune TNF-R 1 Is a Key Event in the Induction of Apoptosis of Oligodendrocytes via Fas and (2005) (0)
- Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis (2022) (0)
- A8.10 Cell death sensitisation in TNF-exposed IKK2-deficient synovial fibroblasts regulates disease outcome in modelled arthritis (2016) (0)
- Antibodies against syndecan-4 reduce cartilage destruction in RA-like disease of htnf transgenic mice (2010) (0)
- SY-6 Cells and signals in models of TNF-driven pathophysiology (2008) (0)
- RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury (2019) (0)
- 04.14 Aortic valve disease co-develops with polyarthritis in the tnf-driven models and shares a common mesenchymal cell-mediated causality (2017) (0)
- Protective role of syndecan-4 in experimental colitis (2012) (0)
- P3790Anti TNF alpha treatment restores endothelial dysfunction in rheumatoid arthritis mice: role of LOX-1 and arginase (2018) (0)
- The INFRAFRONTIER research infrastructure and EMMA: The European mouse mutant archive. (2014) (0)
- Harnessing murine models of Crohn’s disease ileitis to advance concepts of pathophysiology and treatment (2021) (0)
- Effects of cerebral injury on transgenic mice expressing the human HSP70 (1995) (0)
- OP0207 Transmembrane TNF-Alpha Reverse Signaling Leading To TGF-Beta Production Is Selectively Activated by Anti-TNF-Alpha Targeting Molecules (2016) (0)
- Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis (2019) (0)
- Antibodies against syndecan-4 reduce cartilage destruction and the progression after onset in RA-like disease of hTNF transgenic mice (2011) (0)
- 05.17 An integrated chemoinformatics-aided pipeline for the discovery of small–molecule dual inhibitors of tnf and rankl (2017) (0)
- Inflammatory tissue damage in chronic destructive arthritis is regulated by FHL2 (2010) (0)
- a-Amanitin insensitive transcription ofthehumanE-globin gene (1985) (0)
- Stereotactic radiation therapy in painful bone metastases. (2014) (0)
- Sterilization and its behavioral effects on free-ranging female rhesus monkeys (Macaca mulatta). (1991) (0)
- Analysis of Osteoimmune Interactions in Transgenic Mice Overexpressing Human RANKL (2015) (0)
- P018 Membrane-bound TNF induces protective cell-mediated immune responses to M. bovis BCG infection: Regulation of transmembrane TNF and TNF receptors mediating protection (2012) (0)
- [Peri- and paranephritic abscess]. (1972) (0)
- P054 The impact of intestinal stenosis on the expression of Crohn’s disease in young mice with genetic predisposition (2020) (0)
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