Laura Machesky
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Professor of Cancer Biology
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Biology
Why Is Laura Machesky Influential?
(Suggest an Edit or Addition)According to Wikipedia, Laura Machesky FRSE FMedSci is a British-American cancer research scientist currently based in the University of Cambridge. Professor Machesky is the Sir William Dunn Professor of Biochemistry in the Department of Biochemistry, and the current president of the British Society for Cell Biology.
Laura Machesky's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex (1998) (942)
- The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts (1997) (802)
- Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. (1999) (775)
- Phagocytosis and the actin cytoskeleton. (2001) (693)
- Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3 (2000) (525)
- Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose (1994) (514)
- Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. (1991) (464)
- The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. (1990) (458)
- Actin dynamics at the leading edge: from simple machinery to complex networks. (2009) (430)
- Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes (2001) (412)
- Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization (1997) (406)
- Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. (2001) (366)
- The Arp2/3 complex: a multifunctional actin organizer. (1999) (328)
- Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3 (2000) (303)
- The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion (2010) (300)
- Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. (2004) (299)
- Rho: a connection between membrane receptor signalling and the cytoskeleton. (1996) (295)
- Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. (1999) (278)
- Lamellipodia and filopodia in metastasis and invasion (2008) (276)
- Signaling to Actin Dynamics (1999) (266)
- Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis. (2006) (234)
- Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow* (2005) (232)
- Rho-Kinase and Myosin-II Control Phagocytic Cup Formation during CR, but Not FcγR, Phagocytosis (2002) (231)
- Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53 (2005) (231)
- Mechanism of the interaction of human platelet profilin with actin (1991) (225)
- Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (1997) (222)
- Fascin: Invasive filopodia promoting metastasis. (2010) (175)
- Visualization and Molecular Analysis of Actin Assembly in Living Cells (1998) (175)
- LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells (2010) (171)
- Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation (1999) (171)
- A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity (2010) (167)
- P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. (2011) (166)
- N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods (2012) (165)
- Actin-bundling proteins in cancer progression at a glance (2012) (154)
- Mitochondrial permeabilisation engages NF-κB dependent anti-tumour activity under caspase deficiency (2017) (153)
- Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. (2001) (145)
- Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis (2011) (144)
- The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension (2001) (140)
- Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3. (2000) (124)
- The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration (2011) (123)
- Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium (2017) (123)
- Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. (2005) (122)
- Dictyostelium RasG Is Required for Normal Motility and Cytokinesis, But Not Growth (1997) (122)
- Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment (2003) (119)
- Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B (2005) (119)
- The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes (1999) (118)
- Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. (2011) (116)
- Congenital myopathies: diseases of the actin cytoskeleton (2004) (108)
- Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes (2014) (107)
- MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (2003) (107)
- The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C. (1990) (107)
- The WASP-Arp2/3 pathway: genetic insights. (2004) (104)
- Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells (2005) (103)
- Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal (2014) (103)
- Structural requirements and thermodynamics of the interaction of proline peptides with profilin. (1996) (101)
- The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis (2007) (99)
- In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. (2013) (99)
- Podosomes in adhesion, migration, mechanosensing and matrix remodeling (2013) (99)
- Actin dynamics at sites of extracellular matrix degradation. (2006) (96)
- SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods (2012) (93)
- Analysis of the mechanisms of Salmonella‐induced actin assembly during invasion of host cells and intracellular replication (2004) (93)
- Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. (2013) (93)
- Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration. (2015) (93)
- Evaluation of the role of platelet integrins in fibronectin‐dependent spreading and adhesion (2004) (91)
- ERK5 signalling in prostate cancer promotes an invasive phenotype (2011) (91)
- Cryptosporidium parvum Infection Requires Host Cell Actin Polymerization (2001) (88)
- Cells Assemble Invadopodia-Like Structures and Invade into Matrigel in a Matrix Metalloprotease Dependent Manner in the Circular Invasion Assay (2012) (85)
- N‐WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells—implications for axon ensheathment at myelination (2007) (82)
- N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts. (2006) (78)
- Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown (2020) (76)
- Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties (2007) (76)
- Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2 (2005) (71)
- Myopathy mutations in α-skeletal-muscle actin cause a range of molecular defects (2004) (71)
- Putting on the Brakes A Negative Regulatory Function for Ena/VASP Proteins in Cell Migration (2000) (71)
- Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion (2013) (70)
- MIM: a multifunctional scaffold protein (2007) (69)
- Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny (2012) (69)
- Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models. (2003) (68)
- Arp2/3 complex activity in filopodia of spreading cells (2008) (66)
- The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis (2020) (66)
- Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis. (2010) (65)
- Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism (2012) (65)
- Identification of the p16-Arc Subunit of the Arp 2/3 Complex as a Substrate of MAPK-activated Protein Kinase 2 by Proteomic Analysis* (2003) (65)
- The Nance–Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology (2010) (65)
- Abp1p and cortactin, new “hand-holds” for actin (2001) (65)
- Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling (2019) (63)
- MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability (2007) (61)
- Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. (2002) (60)
- WAVE/Scars in platelets. (2005) (60)
- A unique talin homologue with a villin headpiece-like domain is required for multicellular morphogenesis in Dictyostelium (1999) (59)
- Vaccinia virus expresses a novel profilin with a higher affinity for polyphosphoinositides than actin. (1994) (58)
- Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. (2006) (57)
- Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract (2015) (54)
- Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment. (2013) (54)
- Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of Listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex. (2000) (54)
- Myopathy mutations in alpha-skeletal-muscle actin cause a range of molecular defects. (2004) (52)
- Fascin Regulates the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain (2013) (51)
- von Willebrand factor mediates platelet spreading through glycoprotein Ib and αIIbβ3 in the presence of botrocetin and ristocetin, respectively (2006) (50)
- Pseudopod Growth and Evolution during Cell Movement Is Controlled through SCAR/WAVE Dephosphorylation (2012) (50)
- CrkL Directs ASAP1 to Peripheral Focal Adhesions* (2003) (49)
- Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling (2009) (49)
- Fam49/CYRI interacts with Rac1 and locally suppresses protrusions (2018) (48)
- Identification of a novel, actin‐rich structure, the actin nodule, in the early stages of platelet spreading (2008) (46)
- WIP: WASP-interacting proteins at invadopodia and podosomes. (2012) (43)
- Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex (2012) (43)
- Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation (2013) (42)
- Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RAR alpha and calcium-dependent signaling. (2003) (41)
- Actin assembly mediated by Arp2/3 complex and WASP family proteins. (2000) (41)
- CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. (2016) (40)
- The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces (2020) (40)
- Tissue engineering the cancer microenvironment—challenges and opportunities (2018) (39)
- Mtss1 Promotes Cell-Cell Junction Assembly and Stability through the Small GTPase Rac1 (2012) (39)
- Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. (2006) (39)
- Polarised cell migration: intrinsic and extrinsic drivers. (2014) (38)
- Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin (2017) (38)
- Rab 27 a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes ✪ (2001) (35)
- Fascin (2010) (35)
- Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells (2011) (34)
- Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (2003) (34)
- Rocket-based motility: a universal mechanism? (1999) (33)
- Studies on the actin-binding protein HS1 in platelets (2007) (32)
- A major role for Scar/WAVE‐1 downstream of GPVI in platelets (2007) (31)
- Fascin1 in carcinomas: Its regulation and prognostic value (2015) (31)
- Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo. (2012) (30)
- Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. (2003) (29)
- von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively. (2006) (29)
- Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation (2020) (29)
- N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis (2019) (29)
- Overflow in science and its implications for trust (2015) (27)
- Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. (2011) (26)
- Phenotypes of Myopathy-related Actin Mutants in differentiated C2C12 Myotubes (2007) (26)
- “Wunder” F-BAR Domains: Going from Pits to Vesicles (2007) (24)
- G‐protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets (2011) (24)
- Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages (2015) (23)
- Arps: actin-related proteins. (2001) (22)
- Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents (2019) (21)
- The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation (2016) (21)
- Fascin 1 is dispensable for developmental and tumour angiogenesis (2013) (20)
- WIP is necessary for matrix invasion by breast cancer cells. (2014) (20)
- WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion (2016) (20)
- The Tails of Two Myosins (2000) (19)
- Development of a cost-effective automated platform to produce human liver spheroids for basic and applied research (2020) (19)
- Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells. (2003) (19)
- Cell motility: Actin branches out (1998) (19)
- Rac1 in the driver’s seat for melanoma (2012) (17)
- Cell motility: Bare bones of the cytoskeleton (1999) (17)
- The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis (2020) (17)
- Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime (2020) (17)
- Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions. (2012) (16)
- Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour (2016) (16)
- Grab, stick, pull and digest: the functional diversity of actin‐associated matrix‐adhesion structures (2008) (16)
- Rab5 and Rac Team Up in Cell Motility (2008) (14)
- Myopathy-causing actin mutations promote defects in serum-response factor signalling. (2010) (14)
- MRL proteins: Leading Ena/VASP to Ras GTPases (2004) (14)
- Fluorescent erythrocyte ghosts as standards for quantitative flow cytometry. (1995) (13)
- WASP Restricts Active Rac to Maintain Cells’ Front-Rear Polarization (2019) (13)
- Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16‐ARC/ARPC5. T.H. Millard, B. Behrendt, S. Launay, K. Fütterer, L.M. Machesky, Cell Motil.Cytoskeleton (2003) 54(1):81–90. (2003) (13)
- Regulation of WASP PIP2 Pipped By Toca-1? (2004) (12)
- Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X (2019) (11)
- Rac 1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression (2012) (11)
- Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53. (2008) (11)
- Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma (2015) (11)
- Abp 1 p and cortactin , new “ handholds ” for actin (2001) (11)
- Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2y3 complex (polymerizationycell motility) (1999) (11)
- Plagiarism and pathogenesis: common themes in actin remodeling. (2001) (11)
- A Rac1-Independent Role for P-Rex1 in Melanoblasts (2014) (10)
- The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration (2020) (10)
- Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering (2019) (10)
- Loss of N‐WASP drives early progression in an Apc model of intestinal tumourigenesis (2018) (9)
- CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation (2021) (9)
- Super-resolution time-resolved imaging using computational sensor fusion (2021) (9)
- Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3 (2011) (9)
- Simulation of melanoblast displacements reveals new features of developmental migration (2018) (9)
- Rac1 cycling fast in melanoma with P29S (2013) (9)
- A RAC-GEF network critical for early intestinal tumourigenesis (2021) (9)
- CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors (2019) (8)
- CXCR 2 and CXCL 4 regulate survival and self-renewal of hematopoietic stem / progenitor cells (2016) (8)
- The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts (2020) (8)
- Actin on trafficking (2012) (8)
- Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1 (2020) (8)
- Lineage tracing of Pf 4-Cre marks hematopoietic stem cells and their progeny (2012) (8)
- Cell dynamics: a new look at the cytoskeleton (2000) (7)
- The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum (1998) (7)
- The Actin-Binding Protein Profilin Binds to PIP $ _ 2 $ and Inhibits Its Hydrolysis by Phospholipase C Author ( s ) : (2008) (7)
- Phenotypes induced by NM causing α-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes (2009) (6)
- Platelet Lamellipodia Formation is not Required for Thrombus Formation and Stability (2019) (6)
- Actin-based protrusions: promoters or inhibitors of cancer invasion? (2009) (6)
- The liver metastatic niche: modelling the extracellular matrix in metastasis (2021) (6)
- The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice. (2020) (6)
- Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation (2013) (6)
- Melanoblasts on the move (2012) (5)
- Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging. (2021) (5)
- Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein. (2013) (4)
- Chemotaxis in Pacreatic Ductal Adenocarcinoma Metastasis: An Unexpected Role of NWASP in Maintaining Self-Generated Gradients and LPA Receptor Recycling (2018) (3)
- Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described (2020) (3)
- Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche (2022) (3)
- Cell motility: Sharks' teeth and dunes (2002) (2)
- Data fusion for high resolution fluorescence lifetime imaging using deep learning. (2020) (2)
- Seeing around corners: Cells create chemotactic gradients to solve mazes and respond to distant cues in complex environments (2019) (2)
- Enhanced-resolution fluorescence lifetime imaging from multiple sensor data fusion (2020) (2)
- Cell structure and dynamics. (2003) (2)
- Basal Body/centriole Assembly and Continuity This Review Comes from a Themed Issue on Cell Structure and Dynamics Edited (1)
- The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts. (2020) (1)
- Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: A FEBS/EMBO workshop lecture course in Pécs, Hungary (2013) (1)
- MICAL2 fine-tunes Arp2/3 for actin branching (2021) (1)
- Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny (2013) (1)
- Invasion by Force: The C. elegans Anchor Cell Leads the Way. (2019) (1)
- Alan Hall 1952–2015 (2015) (1)
- Theaffinities ofhumanplatelet andAcanthamoeba profilin isoforms forpolyphosphoinositides accountfor their relative abilities toinhibit phospholipase C (1990) (1)
- Predicting cell shapes in melanomas (2014) (1)
- So far, yet so close: α-Catenin dimers help migrating cells get together (2017) (1)
- Megapixel time-gated SPAD image sensor for scientific imaging applications (2021) (1)
- A Rac 1-Independent Role for P-Rex 1 in Melanoblasts (2014) (1)
- Image-based Quantification of Macropinocytosis Using Dextran Uptake into Cultured Cells. (2022) (1)
- CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration (2020) (1)
- Ciliary tip actin dynamics regulate the cadence of photoreceptor disc formation (2022) (1)
- Structure-Function Studies of the Actin Filament System of Acanthamoeba (1989) (1)
- Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation, which controls pseudopod lifetime (2019) (1)
- Wide-field Fluorescence Lifetime Imaging Microscopy with a High-Speed Mega-pixel SPAD Camera (2020) (1)
- 3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration (2021) (1)
- Fam49/CYRI interacts with Rac1 and locally suppresses protrusions (2018) (0)
- Cyrstal structure of CYRI-B/Fam49B (2020) (0)
- Regulation of the actin cytoskeleton by IRSp53 and MIM proteins (2006) (0)
- Edinburgh Research Explorer Activated Mutant NRas(Q61K) Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism (2012) (0)
- The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis (2020) (0)
- HEMATOPOIESIS AND STEM CELLS CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells (2016) (0)
- Actin Filament Assembly: The Search for a Barbed End (2004) (0)
- Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X (2019) (0)
- Going on a (Membrane) Bender to the F-BAR (2011) (0)
- SPRED redirects activated receptors to lysosomes via scaffolding protein NBR1 (2008) (0)
- Alterations In Wnt Signalling In the Megakaryocytic Lineage Leads to Bone Marrow Failure and Myelofibrosis (2010) (0)
- Abstract A113: A fragment-based approach towards the identification of small molecule inhibitors of fascin 1 (2015) (0)
- Autoactivation of small GTPases by the GEF–effector positive feedback modules (2019) (0)
- CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake (2022) (0)
- 100 and 50 years ago (2002) (0)
- Tissue engineering the cancer microenvironment—challenges and opportunities (2018) (0)
- CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1 (2017) (0)
- A RAC-GEF network critical for early intestinal tumourigenesis (2021) (0)
- Structure of N-terminal domain IRSp53/BAIAP2 (2005) (0)
- Trichostatin A suppresses transdifferentiation of rat stellate cells by its effect on the assembly pathway of the actin cytoskeleton. (1999) (0)
- Deadly actin collapse by disulfidptosis (2023) (0)
- Phenotype analysis of Myo10 knockout mice lacking the motorized full‐length, but not the brain‐specific headless isoform (2018) (0)
- More means less: Managing overflow in science publishing (2019) (0)
- CYRI proteins: controllers of actin dynamics in the cellular 'eat vs walk' decision. (2023) (0)
- 381 ABERRANT EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE 5 (ERK5) SIGNALLING PROMOTES CELLULAR MOTILITY AND INVASION IN PROSTATE CARCINOGENESIS (2010) (0)
- Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells (2022) (0)
- Faculty Opinions recommendation of Myosin 1b flattens and prunes branched actin filaments. (2020) (0)
- Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery (2017) (0)
- Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2‐mediated recombination in the melanocyte lineage (2022) (0)
- Cytoskeleton signalling: 7 November 2001 (2002) (0)
- Effect of N-Wasp knockout on tumour burden and survival in murine models of intestinal tumorigenesis and its potential as a prognostic biomarker in human colorectal cancer (2017) (0)
- Edinburgh Research Explorer CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells (2016) (0)
- Crystal structure of CRYI-B Rac1 complex (2020) (0)
- 178 Targeting the Actin Cytoskeletal Protein Fascin as a Novel Modulator of Intestinal Epithelial Cell Proliferation and Colon Cancer (2012) (0)
- WAVE complex regulation by force (2021) (0)
- Faculty Opinions recommendation of Metastatic-niche labelling reveals parenchymal cells with stem features. (2020) (0)
- Chapter 13 Interaction of Profilins with Membrane Lipids (1991) (0)
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