Michel Lazdunski

Q: What Schools Are Affiliated With Michel Lazdunski

Michel Lazdunski is affiliated with the following schools: University of Costa Rica, Côte d'Azur University, Université Laval

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Michel Lazdunski

Biology

#1042

World Rank

#1797

Historical Rank

Biochemistry

#186

World Rank

#236

Historical Rank

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Biology

Michel Lazdunski's Degrees

PhD Biochemistry Côte d'Azur University

Why Is Michel Lazdunski Influential?

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According to Wikipedia, Michel Lazdunski is a French biologist specializing in biochemistry, physiology, pathophysiology, molecular pharmacology and neuroscience. Biography Michel Lazdunski is a chemical engineer , graduate of the École nationale supérieure de chimie de Clermont-Ferrand, PhD in Chemistry-Physics from Laval University in Quebec City in Canada in the laboratory of Ludovic Ouellet, then PhD in Biochemistry . He began his career at the CNRS in 1962 in Marseille where he became Professor of Biochemistry in 1965.He accepted the Chair of Biochemistry at the University of Nice in 1968. He founded the CNRS Biochemistry Centre there, which he managed until 1989, when he moved to the Sophia Antipolis science park to direct the CNRS Institute of Molecular and Cellular Pharmacology, which he had just created and which he managed until 2004. During his academic career in Nice/Sophia Antipolis, he was successively Professor of Biochemistry , Director of Research seconded to the CNRS and Professor of Pharmacology PU-PH .Michel Lazdunski was a member of the Scientific Council and the Board of Directors of the CNRS and the Council of the European Molecular Biology Organisation . He has chaired many committees including the UNECE Life Sciences Committee and the National Coordinating Committee for Life Sciences .

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Michel Lazdunski's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current (1996) (1612)
A proton-gated cation channel involved in acid-sensing (1997) (1279)
Inhalational anesthetics activate two-pore-domain background K+ channels (1999) (639)
The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. (1985) (626)
TASK, a human background K+ channel to sense external pH variations near physiological pH (1997) (613)
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation (1991) (609)
A mammalian two pore domain mechano‐gated S‐like K+ channel (1998) (597)
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning. (1995) (593)
Molecular and functional properties of two-pore-domain potassium channels. (2000) (572)
TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. (1996) (545)
Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons* (1997) (537)
H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels (1998) (525)
Nonsteroid Anti-Inflammatory Drugs Inhibit Both the Activity and the Inflammation-Induced Expression of Acid-Sensing Ion Channels in Nociceptors (2001) (508)
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells* (1997) (502)
Polyunsaturated fatty acids are potent neuroprotectors (2000) (485)
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. (1996) (480)
TREK‐1 is a heat‐activated background K+ channel (2000) (476)
TREK‐1, a K+ channel involved in neuroprotection and general anesthesia (2004) (475)
International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels (2005) (468)
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids (1998) (455)
Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels* (2000) (433)
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. (1987) (425)
Inner Ear Defects Induced by Null Mutationof the isk Gene (1996) (416)
Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels. (1990) (400)
Receptors for a growing family of secreted phospholipases A2. (1999) (398)
Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel* (1999) (395)
International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels (2003) (386)
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel (1995) (379)
TREK‐1, a K+ channel involved in polymodal pain perception (2006) (374)
Cloning and Expression of a Novel pH-sensitive Two Pore Domain K+ Channel from Human Kidney* (1998) (364)
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype (2006) (349)
ASIC3, a sensor of acidic and primary inflammatory pain (2008) (348)
TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel* (1999) (346)
Lysophospholipids Open the Two-pore Domain Mechano-gated K+ Channels TREK-1 and TRAAK* (2000) (342)
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons (2004) (335)
Black mamba venom peptides target acid-sensing ion channels to abolish pain (2012) (334)
Expression cloning of an epithelial amiloride‐sensitive Na+ channel (1993) (333)
The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception (2009) (330)
Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2 * (2002) (329)
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor. (1982) (329)
ProInflammatory Mediators, Stimulators of Sensory Neuron Excitability via the Expression of Acid-Sensing Ion Channels (2002) (323)
A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). (1992) (322)
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1 (2001) (321)
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans(*) (1996) (319)
Molecular mechanism of action of the vasoconstrictor peptide endothelin. (1988) (317)
Kv2.1/Kv9.3, a novel ATP‐dependent delayed‐rectifier K+ channel in oxygen‐sensitive pulmonary artery myocytes (1997) (314)
[3H]nitrendipine receptors in skeletal muscle. (1983) (306)
Human TREK2, a 2P Domain Mechano-sensitive K+Channel with Multiple Regulations by Polyunsaturated Fatty Acids, Lysophospholipids, and Gs, Gi, and Gq Protein-coupled Receptors* (2000) (303)
Properties of KvLQT1 K+ channel mutations in Romano–Ward and Jervell and Lange‐Nielsen inherited cardiac arrhythmias (1997) (298)
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors (2011) (297)
Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels. (1988) (294)
The regulation of the intracellular pH in cells from vertebrates. (1988) (293)
Cloning provides evidence for a family of inward rectifier and G‐protein coupled K+ channels in the brain (1994) (289)
Lipid and mechano-gated 2P domain K(+) channels. (2001) (280)
Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel (*) (1995) (279)
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. (1991) (272)
Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2 * (1997) (272)
Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel (1987) (271)
Molecular Properties of Neuronal G-protein-activated Inwardly Rectifying K+ Channels (*) (1995) (270)
International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels (2005) (268)
Cloning and expression of a membrane receptor for secretory phospholipases A2. (1994) (259)
Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance (2001) (252)
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. (2000) (251)
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel (2000) (250)
Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. (1979) (239)
The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. (1994) (234)
Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices (1989) (231)
Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel. (1994) (230)
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms (2007) (228)
Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel. (1991) (224)
The Acid-sensitive Ionic Channel Subunit ASIC and the Mammalian Degenerin MDEG Form a Heteromultimeric H+-gated Na+ Channel with Novel Properties* (1997) (223)
A phospholipid sensor controls mechanogating of the K+ channel TREK‐1 (2005) (218)
Ciguatoxin is a novel type of Na+ channel toxin. (1984) (211)
The Human 180-kDa Receptor for Secretory Phospholipases A2 (1995) (208)
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. (1994) (207)
Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges. (1972) (206)
Susceptibility of cloned K+ channels to reactive oxygen species. (1995) (202)
H+‐Gated Cation Channelsa (1999) (202)
Sea Anemone Peptides with a Specific Blocking Activity against the Fast Inactivating Potassium Channel Kv3.4* (1998) (201)
An intracellular proton sensor commands lipid‐ and mechano‐gating of the K+ channel TREK‐1 (2002) (195)
ASIC‐like, proton‐activated currents in rat hippocampal neurons (2002) (195)
K+-dependent Cerebellar Granule Neuron Apoptosis (2003) (192)
The role of the Na+/H+ exchange system in cardiac cells in relation to the control of the internal Na+ concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart. (1984) (189)
New Modulatory α Subunits for Mammalian ShabK+ Channels* (1997) (189)
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus. (1993) (189)
Zn2+ and H+ Are Coactivators of Acid-sensing Ion Channels* (2001) (188)
Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels (2003) (186)
Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system. (1984) (184)
The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. (1984) (181)
Novel Human Secreted Phospholipase A2 with Homology to the Group III Bee Venom Enzyme* (2000) (179)
ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone. (1988) (178)
Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. (2002) (176)
Dimerization of TWIK‐1 K+ channel subunits via a disulfide bridge. (1996) (174)
Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom. (1989) (173)
Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. (1989) (170)
Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. (1988) (170)
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (2001) (169)
On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. (1999) (168)
Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone. (1994) (165)
Polyunsaturated fatty acids induce ischemic and epileptic tolerance (2002) (163)
Interaction of phencyclidines with the muscarinic and opiate receptors in the central nervous system (1978) (162)
Kalicludines and Kaliseptine (1995) (161)
How Nerve Growth Factor Drives Physiological and Inflammatory Expressions of Acid-sensing Ion Channel 3 in Sensory Neurons* (2003) (157)
p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK‐1 (2002) (155)
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart. (1991) (155)
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. (1995) (155)
The 2P-domain K+ channels: role in apoptosis and tumorigenesis (2004) (154)
[3H]TCP: a new tool with high affinity for the PCP receptor in rat brain (1983) (153)
Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. (1994) (153)
Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis (1999) (153)
Cloning and Recombinant Expression of a Structurally Novel Human Secreted Phospholipase A2 * (2000) (152)
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes. (1986) (152)
Both Group IB and Group IIA Secreted Phospholipases A2 Are Natural Ligands of the Mouse 180-kDa M-type Receptor* (1999) (150)
Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes (2006) (147)
HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers. (1998) (147)
Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types. (1983) (146)
Molecular Mechanism and Functional Significance of the MinK Control of the KvLQT1 Channel Activity* (1997) (144)
Regulation of expression of the lung amiloride‐sensitive Na+ channel by steroid hormones. (1994) (144)
Intestinal alkaline phosphatase. Physical properties and quaternary structure. (1974) (143)
Sulfonylurea binding sites associated with ATP-regulated K+ channels in the central nervous system: autoradiographic analysis of their distribution and ontogenesis, and of their localization in mutant mice cerebellum (1990) (143)
Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. (1996) (142)
Acid-Sensing Ion Channels in Postoperative Pain (2011) (142)
Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome. (1998) (140)
Flip-flop mechanisms in enzymology. A model: the alkaline phosphatase of Escherichia coli. (1971) (139)
Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscle. (1990) (135)
The Mechanism of Activation of Trypsinogen (1969) (135)
Mutually Protective Actions of Kainic Acid Epileptic Preconditioning and Sublethal Global Ischemia on Hippocampal Neuronal Death: Involvement of Adenosine A1 Receptors and KATP Channels (1999) (135)
A TREK-1-Like Potassium Channel in Atrial Cells Inhibited by &bgr;-Adrenergic Stimulation and Activated by Volatile Anesthetics (2001) (134)
The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3 (1998) (134)
A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels. (1989) (133)
Activation of the nuclear factor-kappaB is a key event in brain tolerance. (2001) (132)
Cross‐talk between the mechano‐gated K2P channel TREK‐1 and the actin cytoskeleton (2005) (131)
Different types of Ca2+ channels in mammalian skeletal muscle cells in culture. (1986) (130)
Secreted phospholipases A2, a new class of HIV inhibitors that block virus entry into host cells (1999) (130)
The protein IsK is a dual activator of K+ and CI− channels (1993) (130)
Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing (2004) (129)
Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension. (1998) (129)
CA2+ CHANNEL INHIBITORS THAT BIND TO PLANT-CELL MEMBRANES BLOCK CA2+ ENTRY INTO PROTOPLASTS (1988) (128)
K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion. (1990) (128)
KATP channel openers, adenosine agonists and epileptic preconditioning are stress signals inducing hippocampal neuroprotection (2000) (128)
Alpha-Linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia (2006) (126)
Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel. (1988) (125)
Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure* (1999) (125)
Structural Elements of Secretory Phospholipases A2 Involved in the Binding to M-type Receptors (*) (1995) (124)
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue (2009) (124)
The structure, function and distribution of the mouse TWIK‐1 K+ channel (1997) (123)
Regulation of calcium channels in aortic muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown. (1987) (123)
APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. (2003) (123)
Expression of apamin receptor in muscles of patients with myotonic muscular dystrophy (1986) (123)
Cloning and Recombinant Expression of a Novel Mouse-secreted Phospholipase A2 * (1999) (122)
Polyunsaturated Fatty Acids Are Cerebral Vasodilators via the TREK-1 Potassium Channel (2007) (122)
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition. (1985) (121)
Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus, and Actinodendron plumosum. (1981) (121)
Endocytic Properties of the M-type 180-kDa Receptor for Secretory Phospholipases A(*) (1996) (121)
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. (1992) (120)
TWIK-2, an Inactivating 2P Domain K+ Channel* (2000) (120)
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception (2014) (118)
Scorpion neurotoxin - a presynaptic toxin which affects both Na+ and K+ channels in axons. (1975) (116)
A pH-sensitive Yeast Outward Rectifier K Channel with Two Pore Domains and Novel Gating Properties (*) (1996) (116)
Protein Kinase C Stimulates the Acid-sensing Ion Channel ASIC2a via the PDZ Domain-containing Protein PICK1* (2002) (116)
Localization and regulation by steroids of the α, β and γ subunits of the amiloride-sensitive Na+ channel in colon, lung and kidney (1995) (115)
FMRFamide-gated sodium channel and ASIC channels: A new class of ionotropic receptors for FMRFamide and related peptides (2006) (115)
Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na Channel Function (*) (1995) (114)
Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+) [3H]PN 200-110. (1984) (114)
Increase of sodium channels in demyelinated lesions of multiple sclerosis (1991) (113)
H(+)-gated cation channels. (1999) (112)
Intestinal alkaline phosphatase. Catalytic properties and half of the sites reactivity. (1974) (111)
Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channel. (1982) (111)
A New K+ Channel β Subunit to Specifically Enhance Kv2.2 (CDRK) Expression* (1996) (111)
AKAP150, a switch to convert mechano‐, pH‐ and arachidonic acid‐sensitive TREK K+ channels into open leak channels (2006) (111)
Mutations Causing Neurodegeneration in Caenorhabditis elegans Drastically Alter the pH Sensitivity and Inactivation of the Mammalian H+-gated Na+ Channel MDEG1* (1998) (109)
Effect of apamin, a toxin that inhibits Ca2+-dependent K+ channels, on learning and memory processes (1991) (108)
Cloning and expression of human TRAAK, a polyunsaturated fatty acids‐activated and mechano‐sensitive K+ channel (2000) (108)
Vasopressin modulates the spontaneous electrical activity in aortic cells (line A7r5) by acting on three different types of ionic channels. (1988) (108)
Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. (2003) (107)
Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes. (1982) (107)
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton‐gated cation channels (2003) (106)
The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. (1994) (105)
Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability (2003) (105)
ASIC2b-dependent Regulation of ASIC3, an Essential Acid-sensing Ion Channel Subunit in Sensory Neurons via the Partner Protein PICK-1* (2004) (105)
Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo (2010) (105)
The antidiabetic sulfonylurea glibenclamide is a potent blocker of the ATP-modulated K+ channel in insulin secreting cells. (1987) (104)
Localization of Structural Elements of Bee Venom Phospholipase A2 Involved in N-type Receptor Binding and Neurotoxicity* (1997) (104)
The Phe-Met-Arg-Phe-amide-activated Sodium Channel Is a Tetramer* (1998) (104)
The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol (1989) (102)
Acid-Sensing Ion Channel 2 Is Important for Retinal Function and Protects against Light-Induced Retinal Degeneration (2004) (101)
Expression of group II phospholipase A2 in rat brain after severe forebrain ischemia and in endotoxic shock (1994) (101)
Modes of Regulation of Shab K+ Channel Activity by the Kv8.1 Subunit* (1997) (98)
Apamin: a specific toxin to study a class of Ca2+-dependent K+ channels. (1984) (98)
Interaction of pyrethroids with the Na+ channel in mammalian neuronal cells in culture. (1980) (98)
Acid Sensing Ion Channels in Dorsal Spinal Cord Neurons (2008) (98)
Structure-function relationship in the binding of snake neurotoxins to the torpedo membrane receptor. (1975) (97)
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers (2012) (96)
Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. (2003) (96)
Long-term potentiation of synaptic transmission in the hippocampus induced by a bee venom peptide (1987) (94)
Biochemical properties of the Na+/H+ exchange system in rat brain synaptosomes. Interdependence of internal and external pH control of the exchange activity. (1985) (94)
Phosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca2+ channel in skeletal muscle membranes by cAMP- and Ca2+-dependent processes. (1986) (93)
Constitution and properties of axonal membranes of crustacean nerves. (1975) (93)
The Potassium Channel Opener (−)‐Cromakalim Prevents Glutamate‐Induced Cell Death in Hippocampal Neurons (1997) (92)
Genotype–phenotype analysis of a newly discovered family with Liddle's syndrome (1997) (91)
Presence of abscisic acid, a phytohormone, in the mammalian brain. (1986) (91)
A Potent Protective Role of Lysophospholipids against Global Cerebral Ischemia and Glutamate Excitotoxicity in Neuronal Cultures (2002) (91)
Interaction of insecticides of the pyrethroid family with specific binding sites on the voltage-dependent sodium channel from mammalian brain (1988) (91)
Molecular properties of amiloride action and of its Na+ transporting targets. (1987) (90)
Structure-function relationships and site of action of apamin, a neurotoxic polypeptide of bee venom with an action on the central nervous system. (1975) (90)
The amiloride-sensitive Na+/H+ antiport in 3T3 fibroblasts. (1983) (90)
Pyrethroid receptor in the insect Na sup + channel: Alteration of its properties in pyrethroid-resistant flies (1989) (90)
The receptor site of the spider toxin PcTx1 on the proton‐gated cation channel ASIC1a (2006) (90)
Dendrotoxin-binding brain membrane protein displays a K+ channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations. (1989) (89)
The Pre-transmembrane 1 Domain of Acid-sensing Ion Channels Participates in the Ion Pore* (1999) (88)
Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle. (1985) (88)
Tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+. (1986) (88)
Cloning and functional expression of a novel degenerin‐like Na+ channel gene in mammals (1999) (88)
MIT1, a black mamba toxin with a new and highly potent activity on intestinal contraction (1999) (87)
The amiloride-sensitive Na+/H+ exchange system in skeletal muscle cells in culture. (1982) (87)
Molecular properties of the action potential Na+ ionophore in neuroblastoma cells. Interactions with neurotoxins. (1978) (87)
Does Sumoylation Control K2P1/TWIK1 Background K+ Channels? (2007) (86)
Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K(+) channel. (2002) (86)
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. (1988) (85)
Altered acetylcholine, bradykinin and cutaneous pressure‐induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link (2007) (85)
(Na+, K+)-activated adenosinetriphosphatase of axonal membranes, cooperativity and control. Steady-state analysis. (1976) (85)
The conformational properties of the basic pancreatic trypsin-inhibitor. (1971) (85)
Biochemical properties of the brain phencyclidine receptor. (1982) (85)
M‐type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit (2000) (84)
Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization. (1990) (84)
Apamin, a neurotoxin specific for one class of Ca2+-dependent K+ channels. (1983) (83)
Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels. (1987) (83)
Multifunctional activity of the extracellular domain of the M-type (180 kDa) membrane receptor for secretory phospholipases A2. (1995) (82)
The Ca2+‐dependent slow K+ conductance in cultured rat muscle cells: characterization with apamin. (1982) (82)
Analysis of molecular aspects of Na+ and Ca2+ uptakes by embryonic cardiac cells in culture. (1977) (81)
The Na+/Ca2+ antiporter in aortic smooth muscle cells. Characterization and demonstration of an activation by phorbol esters. (1988) (81)
Identification, functional expression and chromosomal localisation of a sustained human proton‐gated cation channel (1998) (80)
Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro. (1980) (80)
Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cells in culture: electrophysiological properties and interactions with Ca2+ channel activator (Bay K8644) and inhibitor (PN 200-110). (1986) (80)
Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. (1994) (80)
The all-or-none role of innervation in expression of apamin receptor and of apamin-sensitive Ca2+-activated K+ channel in mammalian skeletal muscle. (1985) (80)
An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain (1997) (80)
Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+ channels in skeletal, cardiac, and smooth muscles. (1986) (79)
Properties of structure and interaction of the receptor for omega-conotoxin, a polypeptide active on Ca2+ channels. (1988) (79)
Riluzole improves functional recovery after ischemia in the rat retina. (1999) (79)
Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. (1999) (79)
Abnormal transverse tubule system and abnormal amount of receptors for Ca2+ channel inhibitors of the dihydropyridine family in skeletal muscle from mice with embryonic muscular dysgenesis. (1985) (78)
Activation of TREK-1 by morphine results in analgesia without adverse side effects (2013) (78)
The role of the Na+/H+ exchange system in the regulation of the internal pH in cultured cardiac cells. (1985) (78)
The Na+/H+ antiport is activated by serum and phorbol esters in proliferating myoblasts but not in differentiated myotubes. Properties of the activation process. (1985) (78)
Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage sensitive K+ channels. (1996) (78)
Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors. (1986) (77)
Cellular Arachidonate-releasing Function of Novel Classes of Secretory Phospholipase A2s (Groups III and XII)* (2003) (76)
Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin gamma. (1984) (76)
Silencing Acid-Sensing Ion Channel 1a Alters Cone-Mediated Retinal Function (2006) (76)
Quantitative autoradiographic mapping in rat brain of the receptor of apamin, a polypeptide toxin specific for one class of Ca2+-dependent K+ channels (1986) (76)
Identification of the Binding Domain for Secretory Phospholipases A2 on Their M-type 180-kDa Membrane Receptor * (1995) (76)
Cloning, Chromosomal Localization, and Physical Linkage of the β and γ Subunits (SCNN1B and SCNN1G) of the Human Epithelial Amiloride-Sensitive Sodium Channel (1995) (75)
Synthesis of new, highly radioactive tetrodotoxin derivatives and their binding properties to the sodium channel. (1980) (75)
The bee venom peptide tertiapin underlines the role of IKACh in acetylcholine‐induced atrioventricular blocks (2000) (75)
The action of cardiotoxins on cardiac plasma membranes. (1982) (75)
The Multivalent PDZ Domain-containing Protein CIPP Is a Partner of Acid-sensing Ion Channel 3 in Sensory Neurons* (2002) (74)
Effects of neurotoxins (veratridine, sea anemone toxin, tetrodotoxin) on transmitter accumulation and release by nerve terminals in vitro. (1977) (74)
Ontogenic appearance of Ca2+ channels characterized as binding sites for nitredipine during development of nervous, skeletal and cardiac muscle systems in the rat (1983) (73)
Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra. (1991) (72)
Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (2000) (72)
ARF6‐dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6 (2004) (72)
The binding of Ca2+ to trypsinogen and its relation to the mechanism of activation. (1967) (72)
Dual control of the intracellular pH in aortic smooth muscle cells by a cAMP-sensitive HCO3-/Cl- antiporter and a protein kinase C-sensitive Na+/H+ antiporter. (1988) (71)
Lipid-soluble toxins thought to be specific for Na+ channels block Ca2+ channels in neuronal cells (1982) (71)
Immunolocalization of the arachidonic acid and mechanosensitive baseline TRAAK potassium channel in the nervous system (1999) (71)
Molecular cloning, functional expression and chromosomal localization of an amiloride‐sensitive Na+ channel from human small intestine (2000) (71)
Expression and Localization of TREK-1 K+ Channels in Human Odontoblasts (2003) (70)
Structure-function relationships of neurotoxins isolated from Naja haje venom. Physiochemical properties and identification of the active site. (1972) (70)
The Na+/H+ exchange system in glial cell lines. Properties and activation by an hyperosmotic shock. (1986) (70)
A search for an 'ouabain-like' substance from the electric organ of Electrophorus electricus which led to arachidonic acid and related fatty acids. (1984) (70)
Disruption of Mitochondrial Respiration Inhibits Volume-Regulated Anion Channels and Provokes Neuronal Cell Swelling (1998) (70)
Isolation and partial characterization of rat CNS axolemma enriched fractions (1978) (69)
The Na+ channel in mammalian cardiac cells. Two kinds of tetrodotoxin receptors in rat heart membranes. (1983) (69)
Purification, sequence, and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel. (1985) (69)
ATP-sensitive potassium channels (KATP) in retina: a key role for delayed ischemic tolerance (2001) (68)
Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage-clamp analysis and biochemical characterization of the receptor. (1982) (68)
Structure-function relationships of sea anemone toxin II from Anemonia sulcata. (1981) (68)
A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis. (1998) (68)
Up- and down-regulation of the mechano-gated K2P channel TREK-1 by PIP2 and other membrane phospholipids (2007) (68)
On the use of tetranitromethane as a nitration reagent. The reaction of phenol side-chains in bovine and porcine trypsinogens and trypsins. (1970) (67)
Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom. (1990) (67)
Memory processing and apamin induce immediate early gene expression in mouse brain. (1993) (66)
ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release. (1993) (66)
ATP‐Sensitive Potassium Channels: An Overview (1994) (66)
The interaction between alpha-chymotrypsin and pancreatic trypsin inhibitor (Kunitz inhibitor). Kinetic and thermodynamic properties. (1973) (65)
Different types of K+ channel current are generated by different levels of a single mRNA. (1992) (65)
Localization and regulation by steroids of the alpha, beta and gamma subunits of the amiloride-sensitive Na+ channel in colon, lung and kidney. (1995) (64)
Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain. (1983) (64)
The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter. (1994) (64)
Na+ channels with binding sites of high and low affinity for tetrodotoxin in different excitable and non-excitable cells. (1982) (64)
Two potent central convulsant peptides, a bee venom toxin, the MCD peptide, and a snake venom toxin, dendrotoxin I, known to block K+ channels, have interacting receptor sites. (1987) (63)
Flip-Flop Mechanisms and Half-Site Enzymes (1972) (63)
Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue. (1987) (63)
Molecular mechanism of cardiotoxin action on axonal membranes. (1976) (63)
Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. (2000) (63)
Structure-function relationships for some metalloalkaline phosphatases of E. coli. (1969) (63)
Lysophosphatidic Acid-operated K+ Channels* (2005) (62)
Mtap2 Is a Constituent of the Protein Network That Regulates Twik-Related K+ Channel Expression and Trafficking (2008) (62)
Differentiation of receptor sites for [3H]nitrendipine in chick hearts and physiological relation to the slow Ca2+ channel and to excitation-contraction coupling. (1984) (62)
Identification of a tetrodotoxin-sensitive Na+ channel in a variety of fibroblast lines (1980) (62)
Properties of association of cardiotoxin with lipid vesicles and natural membranes A fluorescence study (1978) (62)
Calcium channels: Molecular pharmacology, structure and regulation (1988) (62)
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton‐gated channels (2005) (62)
Pseudosubstrates of the sarcoplasmic Ca2+-ATPase as tools to study the coupling between substrate hydrolysis and Ca2+ transport. (1979) (62)
Excitation contraction coupling in skeletal muscle: evidence for a role of slow Ca2+ channels using Ca2+ channel activators and inhibitors in the dihydropyridine series. (1985) (62)
Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells. (1999) (61)
Glutamate-induced overexpression of NMDA receptor messenger RNAs and protein triggered by activation of AMPA/kainate receptors in rat hippocampus following forebrain ischemia (1994) (61)
Properties of receptors for the Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle. Stereospecificity, effect of Ca2+ and other inorganic cations, evidence for two categories of sites and effect of nucleoside triphosphates. (1984) (61)
Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel. (1993) (60)
Polypeptide Toxins as Tools to Study Voltage‐Sensitive Na+ Channels a (1986) (60)
Biochemical characterization of the Na+/K+/Cl- co-transport in chick cardiac cells. (1986) (60)
Ischemic spinal cord injury induced by aortic cross-clamping: prevention by riluzole. (2000) (60)
The receptor site for the bee venom mast cell degranulating peptide. Affinity labeling and evidence for a common molecular target for mast cell degranulating peptide and dendrotoxin I, a snake toxin active on K+ channels. (1988) (60)
Extracellular ATP and UTP control the generation of reactive oxygen intermediates in human macrophages through the opening of a charybdotoxin-sensitive Ca2+-dependent K+ channel. (1997) (60)
Zymogen-enzyme transformations. On the mechanism of activation of prophospholipase A. (1972) (59)
Na+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers. (1987) (59)
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. (2006) (59)
Antipsychotics inhibit TREK but not TRAAK channels. (2007) (58)
Sodium channel and sodium pump in normal and pathological muscles from patients with myotonic muscular dystrophy and lower motor neuron impairment. (1982) (58)
Restoration of dysgenic muscle contraction and calcium channel function by co-culture with normal spinal cord neurons (1987) (58)
Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins. (1993) (58)
Structural Elements for the Generation of Sustained Currents by the Acid Pain Sensor ASIC3* (2009) (57)
The characterization of high-affinity binding sites in rat brain for the mast cell-degranulating peptide from bee venom using the purified monoiodinated peptide. (1984) (56)
Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach–brainstem axis (2008) (56)
The nitrendipine-sensitive Ca2+ channel in chick muscle cells and its appearance during myogenesis in vitro and in vivo. (1984) (56)
Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation. (1983) (56)
Zn2+ and Co2+-alkaline phosphatases of E. coli. A comparative kinetic study. (1969) (56)
Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression? (1993) (56)
Axonal transport of the voltage-dependent Na+ channel protein identified by its tetrodotoxin binding site in rat sciatic nerves (1985) (55)
MLC901, a Traditional Chinese Medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats (2014) (55)
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2. (1992) (55)
The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents (1977) (54)
Reconstitution of highly purified saxitoxin‐sensitive Na+‐channels into planar lipid bilayers. (1984) (53)
Two classes of ouabain receptors in chick ventricular cardiac cells and their relation to (Na+,K+)-ATPase inhibition, intracellular Na+ accumulation, Ca2+ influx, and cardiotonic effect. (1983) (53)
Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties. (2000) (53)
A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system. (1998) (52)
Activation of ATP‐dependent K+ channels by metabolic poisoning in adult mouse skeletal muscle: role of intracellular Mg(2+) and pH. (1995) (52)
Charybdotoxin blocks dendrotoxin‐sensitive voltage‐activated K+ channels (1989) (52)
Autoradiographic analysis in rat brain of the postnatal ontogeny of voltage-dependent Na+ channels, Ca2+-dependent K+ channels and slow Ca2+ channels identified as receptors for tetrodotoxin, apamin and (−)-desmethoxyverapamil (1987) (51)
Solubilization of the nitrendipine receptor from skeletal muscle transverse tubule membranes. Interactions with specific inhibitors of the voltage-dependent Ca2+ channel. (1984) (51)
Diversity and novel pharmacological properties of Ca2+ channels in Drosophila brain membranes. (1989) (51)
Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. (1989) (51)
PP2A-Bγ subunit and KCNQ2 K+ channels in bipolar disorder (2007) (50)
Developmental expression of voltage‐sensitive K+ channels in mouse skeletal muscle and C2C12 cells (1992) (50)
The Na+‐dependent regulation of the internal pH in chick skeletal muscle cells. The role of the Na+/H+ exchange system and its dependence on internal pH. (1984) (50)
The sodium channel in non-impulsive cells. Interaction with specific neurotoxins. (1979) (50)
Secreted phospholipase A2 potentiates glutamate‐induced calcium increase and cell death in primary neuronal cultures (2002) (50)
Crystal structure of a snake venom cardiotoxin. (1987) (49)
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin (2018) (49)
[3H] verapamil binding sites in skeletal muscle transverse tubule membranes. (1984) (49)
Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. (1992) (49)
Charybdotoxin is a new member of the K+ channel toxin family that includes dendrotoxin I and mast cell degranulating peptide. (1989) (49)
Pre‐existence of the active site in zymogens, the interaction of trypsinogen with the basic pancreatic trypsin inhibitor (Kunitz) (1976) (49)
The presence in pig brain of an endogenous equivalent of apamin, the bee venom peptide that specifically blocks Ca2+-dependent K+ channels. (1984) (48)
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells. (1993) (48)
Analogies and differences in the mode of action and properties of binding sites (localization and mutual interactions) of two K+ channel toxins, MCD peptide and dendrotoxin I (1989) (48)
Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the Ca2+ channel structure. (1987) (48)
Solution conformation of leiurotoxin I (scyllatoxin) by 1H nuclear magnetic resonance (1990) (48)
The voltage-dependent Na+ channel of insect nervous system identified by receptor sites for tetrodotoxin, and scorpion and sea anemone toxins. (1985) (47)
Ontogenesis and localization of Ca2+ channels in mammalian skeletal muscle in culture and role in excitation-contraction coupling. (1989) (47)
Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization. (1994) (46)
Na+ channels with high and low affinity tetrodotoxin binding sites in the mammalian skeletal muscle cell. Difference in functional properties and sequential appearance during rat skeletal myogenesis. (1983) (46)
Small conductance chloride channels in the apical membrane of thyroid cells (1990) (46)
Somatostatin activates glibenclamide‐sensitive and ATP‐regulated K+ channels in insulinoma cells via a G‐protein (1988) (46)
Sea anemone toxins affecting potassium channels. (2009) (46)
Pharmacological properties of the interaction of a sea anemone polypeptide toxin with cardiac cells in culture. (1980) (46)
NeuroAiD: Properties for Neuroprotection and Neurorepair (2013) (45)
Specific binding and pharmacological interactions of apamin, the neurotoxin from bee venom, with guinea pig colon. (1982) (45)
Photoaffinity labeling of the digitalis receptor in the (sodium + potassium)-activated adenosinetriphosphatase. (1979) (45)
Endothelin and vasopressin activate low conductance chloride channels in aortic smooth muscle cells (1993) (45)
The Na+/K+/Cl- cotransport in C6 glioma cells. Properties and role in volume regulation. (1988) (45)
Milk alkaline phosphatase. Stimulation by Mg2+ and properties of the Mg2+ site. (1977) (44)
Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel. (1991) (44)
Etude cinetique du mecanisme d'action catalytique de la phosphatase alcaline d’Escherichia coli (1966) (44)
Trypsin--pancreatic secretory inhibitor (Kazal inhibitor) interaction. Kinetic and thermodynamic properties. (1973) (44)
Affinity labeling of the digitalis receptor with p-nitrophenyltriazene-ouabain, a highly specific alkylating agent. (1980) (44)
Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N‐terminal end (1996) (44)
Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells. (1994) (44)
Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus (2004) (44)
Existence of different populations of the dendrotoxin I binding protein associated with neuronal K+ channels. (1988) (43)
The interaction of sea anemone and scorpion neurotoxins with tetrodotoxin-resistant Na+ channels in rat myoblasts. A comparison with Na+ channels in other excitable and non-excitable cells. (1984) (43)
The 1H nuclear-magnetic-resonance spectra of Neurotoxin I and cardiotoxin Vii4 from Naja mossambica mossambica. (1978) (43)
The brain response to the bee venom peptide MCD. Activation and desentization of a hippocampal target (1987) (43)
ATP-sensitive K+ channels in insulinoma cells are activated by nonesterified fatty acids. (1992) (43)
Specific hippocampal lesions indicate the presence of sulfonylurea binding sites associated to ATP-sensitive K+ channels both post-synaptically and on mossy fibers (1991) (43)
Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures (1989) (43)
The association of anhydrotrypsin with the pancreatic trypsin inhibitors. (1974) (43)
Species Diversity and Peptide Toxins Blocking Selectivity of Ether-à-go-go-Related Gene Subfamily K+ Channels in the Central Nervous System (2006) (42)
A novel high affinity class of Ca2+ channel blockers. (1988) (42)
The amino acid sequence of toxin V from Anemonia sulcata. (1982) (42)
NMR analysis and sequence of toxin II from the sea anemone Radianthus paumotensis. (1986) (42)
Negative cooperativity and half of the sites reactivity. Alkaline phosphatases of Escherichia coli with Zn2+, Co2+, Cd2+, Mn2+, and Cu2+ in the active sites. (1974) (42)
Acid-sensing ion channel 3 in retinal function and survival. (2009) (42)
Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel. (1983) (42)
Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas. (1991) (42)
A cardiac tetrodotoxin binding component: biochemical identification, characterization, and properties. (1981) (41)
Identification of a protein component of the Ca2+-dependent K+ channel by affinity labelling with apamin. (1982) (40)
A change in gating mode leading to increased intrinsic Cl‐ channel activity compensates for defective processing in a cystic fibrosis mutant corresponding to a mild form of the disease. (1995) (40)
Physico‐Chemical Properties of Bovine Chymotrypsinogen B (1968) (40)
Exploration of the pore structure of a peptide‐gated Na+ channel (2001) (40)
Identification of different receptor types for toxic phospholipases A2 in rabbit skeletal muscle (1991) (40)
PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder. (2007) (40)
Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. (1994) (40)
dGNaC1, a Gonad-specific Amiloride-sensitive Na+Channel* (1998) (40)
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes. (1985) (39)
[3H]Ethylpropylamiloride, a ligand to analyze the properties of the Na+/H+ exchange system in the membranes of normal and hypertrophied kidneys. (1985) (39)
[3H]nitrendipine labelling of the Ca2+ channel in skeletal muscle. (1982) (39)
Solution structure of APETx1 from the sea anemone Anthopleura elegantissima: A new fold for an HERG toxin (2005) (39)
Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives. (1982) (39)
Properties of the apamin-sensitive Ca2+-activated K+ channel in PC12 pheochromocytoma cells which hyper-produce the apamin receptor. (1986) (38)
Ontogenic appearance of Na+ channels characterized as high affinity binding sites for tetrodotoxin during development of the rat nervous and skeletal muscle systems. (1983) (38)
Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice (1997) (38)
Regulation of Sensory Neuron-specific Acid-sensing Ion Channel 3 by the Adaptor Protein Na+/H+ Exchanger Regulatory Factor-1* (2006) (38)
Regulation of the ATP-sensitive potassium channel. (1990) (37)
Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney. (1998) (37)
Phencyclidine blockade of sodium and potassium channels in neuroblastoma cells (1982) (37)
Potassium ion channels : Molecular structure, function, and diseases (1999) (37)
Differentiation of the fast Na+ channel in embryonic heart cells: interaction of the channel with neurotoxins. (1981) (37)
Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo (1999) (37)
Non-equivalence of the sites of yeast phenylalanyl-tRNA synthetase during catalysis. (1977) (37)
Activation of the voltage-dependent Ca2+ channel in rat heart cells by dihydropyridine derivatives. (1984) (37)
The appearance of voltage-sensitive Na+ channels during the in vitro differentiation of embryonic chick skeletal muscle cells. (1981) (37)
Regulation of a major cloned voltage‐gated K+ channel from human T lymphocytes (1992) (37)
Normal serum and lipoprotein-deficient serum give different expressions of excitability, corresponding to different stages of differentiation, in chicken cardiac cells in culture. (1982) (36)
Brain ischemia alters the density of binding sites for glibenclamide, a specific blocker of ATP-sensitive K+ channels (1990) (36)
ATP/ADP binding sites are present in the sulfonylurea binding protein associated with brain ATP-sensitive K+ channels. (1992) (36)
Purification and subunit structure of the [3H]phenamil receptor associated with the renal apical Na+ channel. (1987) (36)
The calcium channel antagonists receptor from rabbit skeletal muscle. Reconstitution after purification and subunit characterization. (1987) (36)
Identification and affinity labeling of very high affinity binding sites for the phenylalkylamine series of Ca+ channel blockers in the Drosophila nervous system. (1987) (35)
[3H]ethylpropylamiloride, a radio‐labelled diuretic for the analysis of the Na+/H+ exchange system. Its use with kidney cell membranes. (1984) (35)
Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome (2013) (35)
Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. (1986) (35)
The interaction of polypeptide neurotoxins with tetrodotoxin-resistant Na+ channels in mammalian cardiac cells. Correlation with inotropic and arrhythmic effects. (1986) (35)
Structure and regulation of the amiloride-sensitive epithelial sodium channel. (1996) (35)
The presence of Na+ channels in myometrial smooth muscle cells is revealed by specific neurotoxins. (1986) (34)
ATP-sensitive K+ channels. (1994) (34)
On the mechanism of the Zn2+ and Co2+-alkaline phosphatase of E. coli. Number of sites and anticooperativity. (1969) (34)
Comparative properties of the in ovo and in vitro differentiation of the muscarinic cholinergic receptor in embryonic heart cells. (1980) (34)
Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization. (1993) (34)
Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel. (1995) (33)
Paranodal dysmyelination and increase in tetrodotoxin binding sites in the sciatic nerve of the motor end-plate disease (med/med) mouse during postnatal development. (1984) (33)
On the activation of trypsinogen. A study of peptide models related to the N-terminal sequence of the zymogen. (1967) (33)
Comparative changes of levels of nitrendipine Ca2+ channels, of tetrodotoxin‐sensitive Na+ channels and of ouabain‐sensitive (Na+ + K+)‐ATPase following denervation of rat and chick skeletal muscle (1984) (32)
Purification of binding protein for Tityus gamma toxin identified with the gating component of the voltage-sensitive Na+ channel. (1983) (32)
SR33557, an indolizinsulfone blocker of Ca2+ channels: identification of receptor sites and analysis of its mode of action. (1989) (32)
Molecular properties of the apamin-binding component of the Ca2+-dependent K+ channel. Radiation-inactivation, affinity labelling and solubilization. (1984) (32)
Synthesis and mode of action on axonal membranes of photoactivable derivatives of tetrodotoxin. (1979) (32)
Biochemical evidence for pharmacological similarities between alpha-adrenoreceptors and voltage-dependent Na+ and Ca++ channels. (1982) (32)
Receptors for diphenylbutylpiperidine neuroleptics in brain, cardiac, and smooth muscle membranes. Relationship with receptors for 1,4-dihydropyridines and phenylalkylamines and with Ca2+ channel blockade. (1987) (32)
The specificity of the sodium channel for monovalent cations. (1981) (31)
ISK, a slowly activating voltage‐sensitive K+ channel Characterization of multiple cDNAs and gene organization in the mouse (1992) (31)
Trypsinogen, trypsin, trypsin-substrate and trypsin-inhibitor complexes in urea solutions. (1968) (31)
Activation and inhibition of ATP-sensitive K+ channels by fluorescein derivatives. (1992) (30)
Specific photoaffinity labeling of the digitalis binding site of the sodium and potassium ion activated adenosinetriphosphatase induced by energy transfer. (1983) (30)
Classification of Na channel receptors specific for various scorpion toxins (1983) (30)
1H n.m.r. studies of a neurotoxin and a cardiotoxin from Naja mossambica mossambica: amide proton resonances. (1977) (30)
The amiloride-sensitive Na+ channel: from primary structure to function. (1997) (30)
Membrane Potential-regulated Transcription of the Resting K+ Conductance TASK-3 via the Calcineurin Pathway* (2006) (30)
Mevinolin, an inhibitor of cholesterol biosynthesis, drastically depresses Ca2+ channel activity and uncouples excitation from contraction in cardiac cells in culture. (1986) (30)
Characterization of ouabain-resistant mutants of a canine kidney cell line, MDCK. (1983) (29)
On the structural and functional role of carboxylates in chymotrypsinogen A: a comparison with chymotrypsin, trypsinogen and trypsin. (1969) (29)
Lysophosphatidic acid-operated K+ channels. (2013) (29)
The Functional Properties of the Zn2+‐and Co2+‐Alkaline Phosphatases of Escherichia coli (1970) (29)
High affinity receptors for the bee venom MCD peptide. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity (1988) (29)
The effect ofTityus serrulatus scorpion toxin γ on Na channels in neuroblastoma cells (1984) (29)
Transition temperatures of the electrical activity of ion channels in the nerve membrane. (1980) (29)
Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome. (2011) (29)
Identification of an amiloride sensitive Na+/H+ exchange system in brain synaptosomes (1984) (28)
Ion channel effects of antidiabetic sulfonylureas. (1996) (28)
Potassium channels with two pore domains (2000) (28)
Photoaffinity labelling of a small protein component of a purified (Na+‐K+)ATPase (1979) (28)
The Mechanism of Association of Trypsin (or Chymotrypsin) with the Pancreatic Trypsin Inhibitors (Kunitz and Kazal) Kinetics and Thermodynamics of the Interaction (1974) (28)
Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids. (2007) (28)
Specificity and interactions at the cationic sites of the axonal (Na+, K+)-activated adenosinetriphosphatase. (1978) (28)
[3H]phenamil, a radiolabelled diuretic for the analysis of the amiloride-sensitive Na+ channels in kidney membranes. (1986) (28)
A voltage, calcium, and ATP sensitive non selective cation channel in human colonic tumor cells. (1991) (28)
Chapter 12 Potassium Channels with Two P Domains (1999) (27)
Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (1998) (27)
Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves (2000) (27)
Mechanistic analysis of the (Na+,K+)ATPase using new pseudosubstrates. (1977) (27)
Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells (1989) (27)
Axonal transport of Na+,K+-ATPase identified as a ouabain binding site in rat sciatic nerve (1986) (27)
Opening of glibenclamide-sensitive K+ channels in follicular cells promotes Xenopus oocyte maturation. (1992) (27)
Structure-function relationships in the inhibition of synaptosomal dopamine uptake by phencyclidine and analogues: potential correlation with binding site identified with [3H]phencyclidine. (1984) (27)
The secondary structure of the toxin ATX Ia from Anemonia sulcata in aqueous solution determined on the basis of complete sequence-specific 1H-NMR assignments. (1988) (26)
Conditional immortalization of normal and dysgenic mouse muscle cells by the SV40 large T antigen under the vimentin promoter control. (1991) (26)
Neurotoxins specific for the sodium channel stimulate calcium entry into neuroblastoma cells. (1981) (26)
Binding of phencyclidine to rat membranes: Technical aspect (1980) (26)
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers (1991) (26)
MOLECULAR ASPECTS OF THE STRUCTURE AND MECHANISM OF THE VOLTAGE‐DEPENDENT SODIUM CHANNEL * (1980) (25)
1H nuclear-magnetic-resonance studies of the conformation of cardiotoxin VII2 from Naja mossambica mossambica. (1981) (25)
The electrophysiological expression of Ca2+ channels and of apamin sensitive Ca2+ activated K+ channels is abolished in skeletal muscle cells from mice with muscular dysgenesis. (1986) (25)
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling. (1988) (25)
Identification and properties of a novel type of Na+-permeable amiloride-sensitive channel in thyroid cells. (1989) (25)
MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice (2016) (24)
Effects on behaviour and EEG of single chain phospholipases A2 from snake and bee venoms injected into rat brain: search for a functional antagonism. (1996) (24)
Molecular mechanism of the cardiotoxic action of a polypeptide neurotoxin from sea anemone on cultured embryonic cardiac cells. (1977) (24)
Freeze-fracture study of cardiotoxin action on axonal membrane and axonal membrane lipid vesicles. (1981) (24)
The apamin-sensitive Ca2+-dependent K+ channel molecular properties, differentiation and endogenous ligands in mammalian brain. (1985) (23)
HERG and KvLQT 1 / IsK , the Cardiac K 1 Channels Involved in Long QT Syndromes , Are Targets for Calcium Channel Blockers (1998) (23)
Positive effects of the traditional Chinese medicine MLC901 in cognitive tasks (2015) (23)
The Cu2+‐Alkaline Phosphatase of Escherichia coli (1970) (23)
The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia (2018) (23)
Tityusγ toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane (2004) (23)
A new non-voltage-dependent, epithelial-like Na+ channel in vascular smooth muscle cells (1991) (22)
Ontogeny of the (Na+,K+)-ATPase during chick skeletal myogenesis. (1982) (22)
Scorpion neurotoxin. Mode of action on neuromuscular junctions and synaptosomes. (1976) (22)
The regulation of the cytoplasmic free Ca2+ concentration in aortic smooth muscle cells (A7r5 line) after stimulation by vasopressin and bombesin. (1988) (22)
The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism. (1997) (22)
A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin. (1985) (22)
Cloning and cDNA sequence analysis of Lys(49) and Asp(49) basic phospholipase A(2) myotoxin isoforms from Bothrops asper. (2001) (22)
IKs, a slow and intriguing cardiac K+ channel and its associated long QT diseases. (1998) (22)
[3H]phenamil binding protein of the renal epithelium Na+ channel. Purification, affinity labeling, and functional reconstitution. (1990) (22)
Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes (1990) (21)
Compared properties of central and peripheral binding sites for phencyclidine. (1980) (21)
Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal Ca2+ channel. (1986) (21)
The activity of the Na+/H+ antiporter in cultured cardiac cells is dependent on the culture conditions used (1986) (21)
Different functional states of tetrodotoxin sensitive and tetrodotoxin resistant Na+ channels occur during the in vitro development of rat skeletal muscle (1984) (21)
Distribution of voltage-dependent Na+ channels identified by high-affinity receptors for tetrodotoxin and saxitoxin in rat and human brains: quantitative autoradiographic analysis (1988) (21)
Molecular biology of the amiloride‐sensitive epithelial Na+ channel (1996) (20)
The mechanism of activation of trypsinogen. The role of the four N-terminal aspartyl residues. (1969) (20)
Regional expression of a MCD‐peptide and dendrotoxin I‐sensitive voltage‐dependent potassium channel in rat brain (1990) (20)
Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2. (2007) (20)
Two different types of channels are targets for potassium channel openers in Xenopus oocytes (1991) (20)
Structure-function relationships of the acyl-carrier protein of Escherichia coli. (1971) (19)
Pharmacology of ASIC channels (2013) (19)
Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle (1992) (19)
The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. (1996) (19)
Identification of the segment of the catalytic subunit of (Na+,K+)ATPase containing the digitalis binding site. (1982) (18)
Autoradiographic localization of apamin-sensitive Ca2+-dependent K+ channels in rat brain. (1984) (18)
The reactivity of carboxyl groups in chymotrypsinogen (1969) (18)
Pharmacology and regulation of ATP-sensitive K+ channels (2004) (18)
Glibenclamide opens ATP-sensitive potassium channels in Xenopus oocyte follicular cells during metabolic stress. (1995) (18)
The binding of two classes of neurotoxins to axolemma of mammalian brain. (1982) (18)
Properties of receptors for neurotoxic phospholipases A2 in different tissues (1991) (17)
Effectors of ATP-sensitive K+ channels inhibit the regulatory effects of somatostatin and GH-releasing factor on growth hormone secretion. (1992) (17)
Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. (1996) (17)
ATP-sensitive K+ channels reveal the effects of intracellular chloride variations on cytoplasmic ATP concentrations and mitochondrial function. (1990) (17)
Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. (1995) (17)
Identification and properties of phencyclidine-binding sites in nervous tissues. (1983) (17)
On the Diversity of Secreted Phospholipases A2 (1999) (17)
A Physiological inhibitor of gastric secretion, the activation peptide of trypsinogen (1973) (16)
The structural properties of trypsinogen and trypsin. Alkylation and oxidation of methionines. (1968) (16)
Affinity labeling and localization of the ATP binding site in the (Na+,K+)-ATPase. (1983) (16)
Behaviors and neurodegeneration induced by two blockers of K+ channels, the mast cell degranulating peptide and Dendrotoxin I (1997) (16)
Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes. (1992) (16)
A polypeptide toxin from the coral Goniopora (1986) (16)
Purification, subunit structure and pharmacological effects on cardiac and smooth muscle cells of a polypeptide toxin isolated from the marine snail Conus tessulatus. (1986) (15)
The effect of Tityus serrulatus scorpion toxin gamma on Na channels in neuroblastoma cells. (1984) (15)
Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels. (1994) (15)
8-Methoxypsoralen blocks ATP-sensitive potassium channels and stimulates insulin release. (1992) (15)
Properties of the interaction of the sodium channel with permeant monovalent cations. (2005) (15)
TMB-8 (8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenzoate) inhibits the ATP-sensitive K+ channel. (1992) (15)
Specific binding of toxin II from Centruroides suffusus suffusus to the sodium channel in electroplaque membranes. (1982) (15)
Molecular Mechanism of Endothelin‐1 Action on Aortic Cells (1989) (14)
Affinity labelling of the tetrodotoxin-binding component of the Na+ channel. (1983) (14)
[3H]Nitrendipine receptors as markers of a class of putative voltage‐sensitive Ca2+ channels in normal human skeletal muscle and in muscle from duchenne muscular dystrophy patients (1986) (14)
Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice (2017) (14)
Two phospholipase A 2 inhibitors from the plasma of Cerrophidion ( Bothrops ) godmani which selectively inhibit two different group-II phospholipase A 2 myotoxins from its own venom : isolation , molecular cloning and biological properties (14)
Ca2+ channel blockers inhibit secretory C1-channels in intestinal epithelial cells. (1990) (14)
A small-conductance charybdotoxin-sensitive, apamin-resistant Ca2+-activated K+ channel in aortic smooth muscle cells (A7r5 line and primary culture) (1992) (14)
Intracellular pH measurements using the fluorescence of 9‐aminoacridine (1984) (14)
Guanidination of lysine-15 in the active site of the basic pancreatic trypsin inhibitor. Implications for complex formation with trypsin and chymotrypsin. (1974) (14)
Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1 (2019) (14)
The conformation of small proteins. The state-diagram of a neurotoxin of Androctonus Australis Hector. (1970) (13)
Interaction of molecules of the phencyclidine series with cardiac cells (1979) (13)
Receptor binding characterization in kidney membrane of [3H]U-37883, a novel ATP-sensitive K+ channel blocker with diuretic/natriuretic properties. (1995) (13)
The Na+/H+ antiport of eukaryotic cells: relationship between the kinetic properties of the system and its physiological function. (1986) (12)
Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney. (1998) (12)
Polypeptide constitution of receptors for apamin, a neurotoxin which blocks a class of Ca2+‐activated K+ channels (1989) (12)
Inhibition of ACh release at an Aplysia synapse by neurotoxic phospholipases A2: specific receptors and mechanisms of action. (1995) (12)
Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. (1989) (12)
Differences in the properties of Na+ channels in muscle surface and T-tubular membranes revealed by tetrodotoxin derivatives (1983) (12)
The IUPHAR compendium of voltage-gated ion channels (2002) (12)
Cerebral glucose utilization after administration of apamin, a toxin active on Ca2+ -dependent K+ channels (1988) (12)
[3H]Nitrendipine Receptors in Skeletal Muscle PROPERTIES AND PREFERENTIAL LOCALIZATION IN TRANSVERSE TUBULES* (2001) (11)
Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. (1994) (11)
Autoradiographic localization of tetrodotoxin-sensitive Na+ channels in rat brain (1984) (11)
Dihydropyridine‐Sensitive Ca2+ Channels: Molecular Properties of Interaction with Ca2+ Channel Blockers, Purification, Subunit Structure, and Differentiation (1986) (11)
The Apamin-Sensitive Ca 2+ -Dependent K + Channel: Molecular Properties, Differentiation, Involvement in Muscle Disease, and Endogeneous Ligands in Mammalian Brain (1988) (11)
Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte (1993) (11)
Transmembrane ionic transport systems and hypertension. (1988) (11)
The voltage-dependent sodium channel is co-localized with the acetylcholine receptor at the vertebrate neuromuscular junction. (1986) (10)
[30] Affinity labeling of the digitalis-binding site (1988) (10)
[A family of receptors for secretory phospholipases A2]. (1996) (10)
Tight and loose metal binding sites in the apoalkaline phosphatase of E. coli. Reconstitution of the Ca2+--phosphatase from the apoenzyme EPR study of the Mn2+-phosphatase. (1970) (10)
MCD peptide and dendrotoxin I activatec-fos andc-jun expression by acting on two different types of K+ channels. A discrimination using the K+ channel opener lemakalim (1991) (10)
The interaction of ervatamine and epiervatamine with the action potential Na+ ionophore. (1981) (10)
Assignment of the Human Amiloride-Sensitive Na+Channel δ Isoform to Chromosome 1p36.3–p36.2 (1996) (10)
Saxitoxin-sensitive Na+ channels: presynaptic localization in cerebellum and hippocampus of neurological mutant mice (1990) (10)
Appearance and Function of Voltage‐Dependent Ca2+ Channels during Pre‐ and Postnatal Development of Cardiac and Skeletal Muscles a (1989) (10)
An in vitro system to study the action potential sodium channel (1980) (10)
Identification and pharmacological properties of binding sites for the atypical thiazide diuretic, indapamide. (1990) (10)
Properties of Na+ channels in fibroblasts. (1982) (10)
Excitation-contraction uncoupling in the developing skeletal muscle of the muscular dysgenesis mouse embryo. (1987) (10)
Synthesis and properties of new photoactivable derivatives of tetrodotoxin. (1981) (10)
Actions, interactions, and apparent affinities of various ceveratrum alkaloids at sodium channels of cultured neuroblastoma and cardiac cells (1982) (9)
The Mn2+- alkaline phosphatase of E. coli (1970) (9)
Infra‐red investigation of the structural transitions of trypsinogen, trypsin, chymotrypsinogen and chymotrypsin (1969) (9)
A micro-radioimmunoassay for apamin. (1984) (9)
Biochemical Properties of the Na+/H+ Exchange System in Rat Brain Synaptosomes OF INTERNAL AND EXTERNAL pH CONTROL OF THE EXCHANGE ACTIVITY* (1985) (9)
Toxin-induced K+ efflux through the Na+ channel of neuroblastoma cells. (2005) (9)
Molecular Properties of the Voltage‐Sensitive Calcium Channel (1987) (8)
(Na+,K+)ATPase levels in preadipocyte cell lines established from genetically-obese and non-obese mice. (1982) (8)
Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos (1994) (8)
CGRP-induced activation of KATP channels in follicular Xenopus oocytes (1994) (8)
Genetic and pharmacological models of muscle inactivity. (1987) (7)
[Calcium channels and calcium antagonists]. (1986) (7)
Molecular Properties of Structure and Regulation of the Calcium Channel a (1988) (7)
The Na+/H+ exchange system in vascular smooth muscle cells. (1990) (7)
Biochemistry, Molecular Pharmacology, and Functional Control of Ca2+ Channels a (1989) (7)
Identification in mammalian brain of an endogenous substance with Na+ channel blocking activities similar to those of tetrodotoxin (1987) (7)
Behavioral effects of modulators of ATP-sensitive K+ channels in the rat dorsal pallidum. (1992) (7)
The background K(+) channel TASK-3 is regulated at both the transcriptional and post-transcriptional levels. (2006) (7)
Crystallization and preliminary x-ray investigation of a protein neurotoxin from the sea anemone Anthopleura xanthogrammica. (1984) (7)
Ontogenesis and localization of Ca 2 + channels in mammalian skeletal muscle in culture and role in excitation-contraction coupling ( voltage clamp / electron microscopy / dihydropyridine / detubulation / triads ) (6)
A new scorpion toxin with a very high affinity for sodium channels. An electrophysiological study. (1984) (6)
Characterization , purification , and affinity labeling of the brain [ 3 H ] glibenclamide-binding protein , a putative neuronal ATP-regulated K + channel ( sulfonylurea / ischemia ) (6)
The cardiac Na + /H + exchange system. Its role in inotropy (1986) (6)
Characterization and partial purification from pheochromocytoma cells of an endogenous equivalent of scyllatoxin, a scorpion toxin which blocks small conductance Ca2+-activated K+ channels (1992) (6)
Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (6)
Localization of the gene for amiloride binding protein on chromosome 7 and RFLP analysis in cystic fibrosis families (1990) (5)
The non-equivalence of the active sites and the mechanism of a mutationally altered E. coli alkaline phosphatase. (1975) (5)
Biochemical studies of the structure, mechanism and differentiation of the voltage-sensitive sodium channel (1980) (5)
CHEMICAL SYNTHESIS AND MOLECULAR PHARMACOLOGY OF HYDROXYLATED 1-(1-PHENYLCYCLOHEXYL)PIPERIDINE DERIVATIVES (1982) (5)
New developments in metabolic syndrome (2005) (5)
A TRADITIONAL CHINESE MEDICINE INDUCES NEUROPROTECTIVE AND NEUROREGENERATIVE BENEFITS AFTER TRAUMATIC BRAIN INJURY IN RATS (2014) (5)
A genetic model for the study of abnormal nerve-muscle interactions at the level of excitation-contraction coupling: the mutation muscular dysgenesis. (1990) (5)
Phosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca 2 " channel in skeletal muscle membranes by cAMP-and Ca 2 "-dependent processes ( 1 , 4-dihydropyridine receptor / calmodulin / calcineurin / transverse-tubule membranes ) (5)
Indolizinsulphones. A class of blockers with dual but discriminative effects on L-type Ca2+ channel activity and excitation-contraction coupling in skeletal muscle (1991) (5)
A search for the apamin receptor in the central nervous system. (1979) (4)
Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel (1993) (4)
Chapter 5 IsK: A Novel Type of Potassium Channel Regulatory Subunit (1999) (4)
Effects of Cardiotoxins on Membrane Ionic Channels (1984) (4)
The Role of Carboxylates and Phenol Side-chains in the Activity and Conformation of Trypsinogen, Trypsin, Chymotrypsinogen, and Chymotrypsin (1970) (4)
Digitalis receptors in cardiac cells and their relation with positive inotropic and cardiotoxic effects. (1984) (4)
Assignment of the human amiloride-sensitive Na+ channel delta isoform to chromosome 1p36.3-p36.2. (1996) (4)
New Ouabain Derivatives to Covalently Label the Digitalis Binding Site (1983) (4)
Interaction of neurotoxins with the selectivity filter and the gating system of the sodium channel. (1979) (3)
Solution structure of phrixotoxin 1 (2004) (3)
Developmental properties of the fast Na+ channel in embryonic cardiac cells using neurotoxins. (1982) (3)
Identification of the Ca2+ current activated by vasoconstrictors in vascular smooth muscle cells (1994) (3)
Antidiabetic sulfonylureas antagonize somatostatin inhibition of prolactin secretion in vitro. (1992) (3)
Acid-Sensing Ion Channels in the nervous system (2015) (3)
PROPERTIES OF ASSOCIATION OF CARDIOTOXIN WITH I2fPID VESICLES AND NATURAL MEMBRANES (1978) (3)
The molecular basis of ciguatoxin action (1990) (3)
Influence of pancreatic secretion on gastric secretion in dogs. (1974) (3)
Coexistence of two classes of glibenclamide-inhibitable ATP-regulated K+ channels in avian skeletal muscle (1995) (3)
[3H]-tetrodotoxin binding in neuronal and non-neuronal spinal cord cultures. (1986) (3)
An Example of “Quasi-Irreversible” Protein-Protein Interaction: The Trypsin-Pancreatic Trypsin Inhibitor Complex (1972) (3)
Diazoxide for cerebral protection during deep hypothermic circulatory arrest: is it really safe? (2002) (2)
The structure of the amiloride sensitive apical Na+ channel from pig kidney. (1988) (2)
Phenotypic and functional reversion of muscular dysgenesis by heterotypic fibroblast-myotube fusion in vitro. (1990) (2)
Purification of binding protein for Tityus y toxin identified with the gating component of the voltage-sensitive Na ' channel ( Electrophorus electricus electroplax / electrical excitability / ion transport / scorpion toxin / tetrodotoxin ) (2)
The functional properties of the Zn2(plus)-and Co2(plus)-alkaline phosphatases of Escherichia coli. Labelling of the active site with pyrophosphate, complex formation with arsenate, and reinvestigation of the role of the zinc atoms. (1970) (2)
Characterization and partial purification from pheochromocytoma cells of an endogenous equivalent of scyllatoxin, a scorpion toxin which blocks small conductance Ca(2+)-activated K+ channels. (1992) (2)
Agonists and antagonists of ATP-sensitive potassium channels. (1992) (2)
Purification, affinity labeling, and reconstitution of voltage-sensitive potassium channels. (1992) (2)
Binding of phencyclidine to rat brain membranes: technical aspect. (1980) (2)
Is the vascular TREK-1 potentially involved in PUFAS-induced neuronal activation (2005) (1)
SINGLE CHANNEL FORMATION OF COOPERATIVELY INTERACTING UNITS OF THE HIGHLY-PURIFIED Na-CHANNEL PROTEIN (1985) (1)
Control and diseases of sodium dependent transport proteins and ion channels : proceedings of the First International Conference held in Shizuoka, Japan, 24-28th August 1999 (2000) (1)
Molecular cloning of a murine N‐type calcium channel α1 subunit (1)
Structure of the bacterial virus PF-1: An infared linear dichroism study (1986) (1)
Ion channels and epilepsy (2006) (1)
Affinity labeling of the digitalis-binding site. (1988) (1)
Properties of KvLQT 1 K channel mutations in Romano – Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias are not a frequent diagnosis , acquired forms of abnormal (2013) (1)
[Structural study of trypsinogen and trypsin. State diagrams]. (1967) (1)
New scorpion toxins with a very high affinity for Na+ channels. Biochemical characterization and use for the purification of Na+ channels. (1984) (1)
Notice on Short Communications (1974) (1)
Digitalis receptors affinity labelling and relation with positive inotropic and cardiotoxic effects. (1984) (1)
Corrigendum to “MLC 901, a Traditional Chinese Medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats” [Neuroscience 277 (2014) 72–86] (2014) (1)
Physico-chemical properties of bovine chymotrypsinogen B. A comparative study with trypsinogen and chymotrypsinogen A. (1968) (1)
Receptor sites for dihydropyridines associated with calcium channel blockade/calcium channel activation (1984) (1)
Voltage-gated potassium channels (Kv) in GtoPdb v.2021.3 (2021) (1)
[On the morphology of porcine and bovine trypsins. Study of reversible denaturations]. (1965) (1)
CARDIOTOXINS ON CARDIAC PLASMA MEMBRANES (1982) (1)
[The Na+/H+ exchanger in eukaryotic cells: biochemical and pharmacological properties and physiological role]. (1985) (1)
[The amiloride sensitive sodium channel]. (1996) (1)
Mouse Groups I, II, V, X, and XII Secreted Phospholipases A 2 (2002) (1)
A family of receptors for venom phospholipases A2 (1997) (1)
Evidence for a selective blockade of Cav1.2 versus Cav1.3 by the mamba toxin calciseptine in the mouse heart (2020) (1)
Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related gene potassium channels from the venom of the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin (2005) (1)
Biophysical, pharmacological and developmental properties of ATP-sensitive K+ channels in cultured myotomal muscle cells from Xenopus embryos (1995) (1)
[SOME OBSERVATIONS ON THE MODE OF ACTION OF MONOGLYCERIDE TRANSACYLASE AND DIGLYCERIDE TRANSACYLASE OF INTESTINAL MUCOSA]. (1964) (1)
K+ Channels: Structure, Function, Regulation, Molecular Pharmacology and Role in Diseased States (1989) (1)
dGNaC 1 , a Gonad-specific Amiloride-sensitive Na 1 Channel (1998) (1)
Sulfonylureas-sensitive KATP channels modulate [3M]GABA release in substantia nigra (1990) (1)
6 Monoclonal Antibodies That Coimmunoprecipitate the 1 , 4-Dihydropyridine and Phenylalkylamine Receptors and Reveal the Ca 2 + Channel Structure (1)
How NGF drives physiological and inflammatory expressions of Acid-Sensing Ion Channel 3 in sensory neurons (2003) (1)
[Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin]. (2000) (1)
Sulfonylureas-sensitive K+-ATP channels modulate [3H] gaba release in substantia nigra (1990) (1)
Na+-pathways into and out of the cardiac cell: Relationship to inotropy (1986) (1)
Immunohistochemistry and in situ Zymography to Assess Matrix Metalloproteinases Expression and Activation by Latanoprost in Rat Uveoscleral Pathway (2008) (0)
The use of activators of potassium channels k2p as qu'antalgiques. (2009) (0)
[On the reactivity of ionisable functions of bovine and porcine trypsinogens]. (1965) (0)
Expression cloning of an epit~elial a~ilori~e-sensitive Na" channel A new channel type with monologues to C~e~or~~~~i~i~ eZeg~~~ d~generins (1993) (0)
The all-or-none role of innervation in expression of apamin receptor and of apamin-sensitive Ca 2 +-activated K + channel in mammalian skeletal muscle ( Ca 2 +-dependent K + conductance / denervation ) (0)
On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian Enzymes and HIV-1 Antiviral Properties (2001) (0)
Twenty questions: Highlighting the pitfalls and possibilities of drug research (2004) (0)
Isolation and characterization of Phlotoxin 1, a novel peptide from spider venom acting selectively on voltage-gated Na+ channels (2005) (0)
Table of Contents (1984) (0)
The regulation of the volume and intracellular pH in glial cells (1988) (0)
Calcium channels and calcium antagonists [CALCIUMKANALE UND CALCIUMANTAGONISTEN] (1986) (0)
Acid sensitive neural mammal cation channel whose cloning and application (1998) (0)
SOLUBILIZATION, AFFINITY LABELLING AND PURIFICATION OF THE DIHYDROPYRIDINE RECEPTOR OF THE VOLTAGE-DEPENDENT CALCIUM CHANNEL FROM RABBIT SKELETAL MUSCLE TRANSVERSE TUBULE MEMBRANES (1985) (0)
5(th) EBSA & 15(th) IUPAB International Biophysics Congress Montpellier (France), August 27(th)-September 1(st), 2005 (2005) (0)
Säugtieren Kalikanalfamilie whose cloning and application for drug screening (1996) (0)
Table of Contents (1996) (0)
Using K2P potassium channel activators as analgesics (2010) (0)
GDP and intracellular Cl− depletion activate ATP-sensitive K+ channels in insulinoma cells by inhibiting oxidative phosphorylation (1990) (0)
Frontiers in chemistry plenary lecture: Molecular aspects of nerve conduction (1975) (0)
PresentationMNK study of the solution structure of protein G4 (84 residues, 5 disulfide bridges) from Dendroaspis polylepis (black mamba snake) venom (1996) (0)
[The alkaline isophosphatases of Escherichia coli. Isolation, kinetic and structural properties]. (1967) (0)
Different types of Ca 2 l channels in mammalian skeletal muscle cells in culture ( electrophysiology / excitation-contraction coupling / excitable membranes ) (0)
with a Unique Pore Structure Channel Subunit and a Human Homologue Cloning of a New Mouse Two-P Domain (2013) (0)
Voltage-Dependent Calcium Channels: Structure and Regulation in Normal and Abnormal States (1989) (0)
Channels in Human Odontoblasts + Expression and Localization of TREK-1 K (2003) (0)
Proton-dependent na + channel inhibitory polypeptide (2001) (0)
Peptidic toxins homologous to the Kunitz inhibitor in the African mamba snake venoms of the Dendroaspis genus: a versatile molecular architecture for the blocking of neuronal ionic channels (1995) (0)
[Demonstration and purification of the toxin from Conus tessulatus. Toxicity in the crab Carcineus maenas and in muscle tissue from the guinea pig]. (1984) (0)
Alpha-linolenic acid and riluzole, activators of 2 pore-domain K + channels afford brain protection against focal brain ischemia (2005) (0)
Solution Structure of Psmalmotoxin 1, the First Characterized Specific Blocker of ASIC1a NA+ channel (2003) (0)
391 New ideas on the origin of L-dopa-induced dyskinesias: age, genes and neural plasticity (2005) (0)
Blockers ACE-Inhibitors , Beta ( β )-Blockers Definition (2006) (0)
[Preparation of a purified intestinal alkaline phosphatase]. (1961) (0)
New family of mechanosensitive and active human potassium channels by polyunsaturated fatty acids and their use (2000) (0)
1277 – CHARACTERIZATION OF THE AXONAL ACTION POTENTIAL Na+ CHANNEL BY AFFINITY LABELLING WITH TETRODOTOXIN DERIVATIVES (1978) (0)
[An ionic channel involved in the skin protection against pressure]. (2013) (0)
Solution structure of leiurotoxin I by 1H magnetic resonance (1991) (0)
The Na + channel in mammalian heart. Two kinds of tetrodotoxin receptors (1984) (0)
A family of receptors for toxic phospholipases A2 (1996) (0)
New family of mammalian potassium channels, their cloning and use especially for screening drugs (1996) (0)
MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES (1999) (0)
The Na+ Channel in Mammalian Cardiac Cells (2011) (0)
Sodium Pathways In and Out of the Cardiac Cells: Relationship to Inotropy (1987) (0)
Implications for Diabetic Neuropathy Potentials in Rat Myelinated Sensory Fibers: Hyperosmolar Solutions Selectively Block Action (2015) (0)
Half-of-the-Sites Reactivity and Flip-Flop Type Mechanisms: an Example, Alkaline Phosphatase (1973) (0)
Dual Action of Fluorescein Derivatives on KATP Channels (1992) (0)
The structure of the epithelium Na channel of pig kidney (1988) (0)
Potassium channels: Structure-function relationships, diversity, and pharmacology (1992) (0)
2P-DOMAIN K+ CHANNELS: STRUCTURE, PHYSIOLOGICAL FUNCTIONS, PHARMACOLOGY AND THERAPEUTIC IMPLICATIONS (2000) (0)
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Dihydropyridine-sensitive Ca2" channels in mammalian skeletal (2016) (0)
Family of potassium channels of mammals, their cloning and application for drug screening (1996) (0)
Cardioprotective effects of chinese medicine NurAiD™II (2017) (0)
Species Diversity and Peptide Toxins Blocking Selectivity of Ether-a`-go-go –Related Gene Subfamily K (cid:1) Channels in the Central Nervous System (2006) (0)
ABA and Temperature Signaling in Sponges (2002) (0)
1H assignment of APETx1 (2005) (0)
[ON THE CONFORMATION OF THE TRYPSINS OF PORK AND BEEF]. (1964) (0)
Kplus channels:structure, regulation, molecular pharmacology and involvement in disease states (1992) (0)
[Kinetic study of the mechanism of catalytic action of Escherichia coli alkaline phosphatase]. (1966) (0)
Pedro Brugada and Peter Schwartz share the Lefoulon-Delalande Foundation Scientific Prize 2019. (2019) (0)
The Cu2 plus-alkaline phosphatase of Escherichia coli. (1970) (0)
[Identification, function mechanisms and regulation of potassium channels sensitive to ATP which are targets of sulfonylureas used in the treatment of type II diabetes mellitus]. (1989) (0)
Intracellular pH of Cardiac Cells: Hormonal Regulation and Role in Ischemia (1989) (0)
Binding of sea anemone toxin to rec system of sodium channel in synapti (scorpion neurotoxin/synaptosomes) (2016) (0)
(electrophysiology/excitation-contraction coupling/excitable membranes) (2017) (0)
External blockade of the major cardiac delayed-rectifier K + channel ( Kvl . 5 ) by polyunsaturated fatty acids ( ] K + conductance / arachidonic add / fish oil / antiarrhythmics / isamil ) (0)
Action of Natural Toxins on Cardiac Ionic Channels (1989) (0)
219 The stimulation of the amiloride sensitive Na+/H+ exchanger in 3T3 cells by serum. (1983) (0)
1H chemical shift assignments for Psalmotoxin 1 (2003) (0)
Mitogenicity of sea anemone toxin its relation to the tetrodo toxin sensitive sodium channel present in fibroblasts (1980) (0)
[Regulation of ATP-dependent potassium channels]. (1991) (0)
1276 – MOLECULAR PROPERTIES OF THE ACTION POTENTIAL NA+ IONOPHORE. INTERACTIONS WITH NEUROTOXINS (1978) (0)
ATP-Sensitive K + Channels : Molecular Pharmacology, Regulation and Role in Diseased States (1992) (0)
Using an inhibitor of glutamate release in the treatment of retinal ischemia (1998) (0)
Epilepsy and other neurological disorders Ion channels and epilepsy (2006) (0)
[Different molecular species of bovine trypsinogen and trypsin]. (1965) (0)
[Biochemistry of a voltage-sensitive sodium channel structure, mechanism and differentiation]. (1982) (0)
Selectivity of action between pyrethroids and combined DDT-pyrethroid insecticides on Na+ influx into mammalian neuroblastoma (1985) (0)
Chemical Synthesis and Molecular Pharmacology of Hydroxylated 1-( 1-Phenylcyclohexy 1 ) piperidine Derivatives 43 1 (2001) (0)
Four novel tarantula toxins acting as potent and selective ligands on TTX-r and TTX-s voltage-gated Na+ channels (2005) (0)
The Expanding Family of Secreted Phospholipases A2: diversity of enzymes for diverse functions? (2000) (0)
The cardiac Na+Jß+ exchange system. Its roJe in inotropy (1986) (0)
The Expanding Family of Secreted Phospholipases (2000) (0)
1115 – EFFECTS OF VERATRIDINE, SCORPION TOXIN AND TETRODOTOXIN ON THE UPTAKE AND RELEASE OF (3H)-GABA FROM RAT BRAIN SYNAPTOSOMES (1977) (0)
Use of riluzole for treating or preventing adverse effects of anti-cancer agents (2010) (0)
The Mn2plus-alkaline phosphatase of E. coli. (1970) (0)
OD1 and PhlYx, two novel, potent modulators of Nav1.7: potential use as analgesic through different mechanisms (2006) (0)
Neuronal cation channel sensitive to acidity, cloning and its applications mammal. (1998) (0)
Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
Molecular biology and molecular pharmacology of calcium channels (1984) (0)
[KINETIC STUDY OF THE MECHANISM OF CATALYTIC ACTION OF PIG AND OX TRYPSIN]. (1965) (0)
Room E, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Spinal Cord Ischemic Injury Induced by Aortic Cross-Clamping: Effect of Tacrolimus (FK506) A-731 (2000) (0)
Inwardly rectifying potassium channels (KIR) in GtoPdb v.2021.3 (2021) (0)
Biochemistry and Molecular Pharmacology of Ca2+ Channels and Ca2+-Channel Blockers (1988) (0)
Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice (2017) (0)
Analgesic effects of peptidtoxin APETx2 (2009) (0)
Table of Contents (1995) (0)

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