Richard Smeyne
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Biology
Richard Smeyne's Degrees
- PhD Neuroscience University of Pennsylvania
- Bachelors Biology University of Scranton
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Why Is Richard Smeyne Influential?
(Suggest an Edit or Addition)According to Wikipedia, Richard Jay Smeyne is a neuroscientist who is currently Professor and Chair of the Department of Neuroscience at Thomas Jefferson University, where he is also Director of the Jefferson Comprehensive Parkinson's Disease and Movement Disorder Center at the Vickie and Jack Farber Institute for Neuroscience. His research is focused on the cell biology of Parkinson's disease, as well as neuroprotection.
Richard Smeyne's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene (1994) (1008)
- Continuous c-fos expression precedes programmed cell death in vivo (1993) (764)
- Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death (1993) (686)
- Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements (1994) (627)
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte (2009) (542)
- The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. (1996) (508)
- Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease (2001) (440)
- Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue‐specific modulation of receptor function. (1996) (428)
- Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration (2009) (380)
- Glutathione metabolism and Parkinson's disease. (2013) (354)
- The MPTP model of Parkinson's disease. (2005) (351)
- Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. (2004) (321)
- Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements (1995) (318)
- A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons. (1990) (289)
- Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. (2005) (246)
- Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. (1997) (245)
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. (2010) (237)
- Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier (2013) (235)
- Viral parkinsonism. (2009) (219)
- A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. (2003) (216)
- Fos-IacZ transgenic mice: Mapping sites of gene induction in the central nervous system (1992) (209)
- TrkA, But Not TrkC, Receptors Are Essential for Survival of Sympathetic Neurons In Vivo (1996) (206)
- Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system (1994) (203)
- Local Control of Granule Cell Generation by Cerebellar Purkinje Cells (1995) (200)
- Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. (1999) (188)
- Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice (1995) (173)
- Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study (1989) (159)
- Control of segment-like patterns of gene expression in the mouse cerebellum (1993) (150)
- Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity (2008) (136)
- A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse (2009) (133)
- Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus (1999) (132)
- Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. (1998) (131)
- The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development (2002) (129)
- Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. (2011) (121)
- Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency. (2009) (114)
- Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment. (1999) (111)
- Dynamic organization of developing Purkinje cells revealed by transgene expression. (1991) (108)
- Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models (2014) (104)
- Exercise: is it a neuroprotective and if so, how does it work? (2014) (102)
- Exercise protects against MPTP-induced neurotoxicity in mice (2010) (101)
- fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. (1992) (99)
- Inflammatory Effects of Highly Pathogenic H5N1 Influenza Virus Infection in the CNS of Mice (2012) (89)
- Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice (2012) (89)
- Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo (2018) (84)
- COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside (2020) (83)
- Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. (2010) (82)
- Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. (2003) (79)
- The Cyclin-Dependent Kinase Inhibitors p19Ink4d and p27Kip1 Are Coexpressed in Select Retinal Cells and Act Cooperatively to Control Cell Cycle Exit (2002) (78)
- GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism (2007) (76)
- Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse (1997) (72)
- MPTP and SNpc DA neuronal vulnerability: Role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. (2009) (72)
- Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice (2016) (71)
- Analysis of Cerebellar Development in math1 Null Embryos and Chimeras (2004) (69)
- Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells. (2002) (69)
- Purkinje cell loss is due to a direct action of the weaver gene in Purkinje cells: evidence from chimeric mice. (1990) (67)
- Induction of Microglia Activation after Infection with the Non-Neurotropic A/CA/04/2009 H1N1 Influenza Virus (2015) (65)
- Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson’s disease (2007) (62)
- Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice (2012) (62)
- The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. (1989) (61)
- Central Nervous System Destruction Mediated by Glutamic Acid Decarboxylase-Specific CD4+ T Cells (2010) (60)
- Neurorestoration by physical exercise: moving forward. (2012) (58)
- Isolation of an allele of reeler by insertional mutagenesis. (1994) (57)
- Splice variants of the OB receptor gene are differentially expressed in brain and peripheral tissues of mice. (1999) (57)
- Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis (2017) (56)
- Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior (2016) (53)
- Exercise Does Not Protect against MPTP-Induced Neurotoxicity in BDNF Happloinsufficent Mice (2012) (52)
- Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation (2019) (52)
- Glia cell number modulates sensitivity to MPTP in mice (2005) (50)
- Strain‐dependent susceptibility to MPTP and MPP+‐induced Parkinsonism is determined by glia (2001) (48)
- Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease (2012) (44)
- Genetic Dissection of Strain Dependent Paraquat-induced Neurodegeneration in the Substantia Nigra Pars Compacta (2012) (40)
- Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system. (1992) (38)
- Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta (2007) (37)
- Infection and Risk of Parkinson’s Disease (2020) (36)
- Correspondence between L7‐lacZ‐expressing purkinje cells and labeled olivocerebellar fibers during late embryogenesis in the mouse (1996) (35)
- Mapping of Cbln1‐like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons (2007) (34)
- Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling (2017) (29)
- A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping. (1993) (28)
- Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. (2003) (28)
- Cocaine selectively increases proliferation in the adult murine hippocampus (2010) (28)
- Continuous c-fos expression precedes programmed cell death in vivo (1993) (27)
- Adult and in utero exposure to cocaine alters sensitivity to the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006) (27)
- COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside (2020) (27)
- Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice. (1997) (26)
- Tune into the weaver channel (1995) (26)
- Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson's disease. (2002) (24)
- Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. (1998) (24)
- Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis (2019) (23)
- Murine MPDZ‐linked hydrocephalus is caused by hyperpermeability of the choroid plexus (2018) (23)
- HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta (2015) (23)
- Regulation of proto-oncogene expression in adult and developing lungs (1993) (22)
- Regional differences in cortical dendrite morphology following in utero exposure to cocaine. (2003) (19)
- Neurochemical Measurement of Adenosine in Discrete Brain Regions of Five Strains of Inbred Mice (2014) (18)
- Alterations in glutathione S-transferase pi expression following exposure to MPP+ -induced oxidative stress in the blood of Parkinson's disease patients. (2011) (17)
- Expression of Ob Receptor Splice Variants During Prenatal Development of the Mouse (2000) (16)
- Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. (2016) (16)
- Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin (2019) (15)
- Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats. (1996) (12)
- Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis (2020) (12)
- Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). (1990) (12)
- SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus (2015) (12)
- Corrigendum to “Local control of granule cell generation by cerebellar purkinje cells” [Mol. Cell. Neurosci. 6 (1995) 230–251] (2006) (11)
- p75 Regulates Purkinje Cell Firing by Modulating SK Channel Activity through Rac1* (2014) (11)
- Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice (2005) (9)
- Foreword: Exercise and the Brain (2010) (9)
- Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis (2021) (9)
- Failure of Neocortical Transplants to Alter Seizure Susceptibility in Previously Kindled Rats (1987) (8)
- COVID‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism (2022) (8)
- Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice (2022) (8)
- Hemangiosarcomas , Medulloblastomas , and Other Tumors in Ink 4 c / p 53-null Mice 1 (2003) (7)
- From Man to Mouse: The MPTP Model of Parkinson Disease (2015) (6)
- Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus (2021) (5)
- Correction: Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice (2012) (5)
- Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease (2022) (5)
- Transgenic approaches to cerebellar development. (1997) (4)
- Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (2012) (4)
- Cell Death in Parkinson’s Disease (2004) (4)
- Abnormalities in premigratory granule cells in the weaver cerebellum defined by monoclonal antibody OZ42 (2004) (2)
- The development of the weaver cerebellum (1989) (2)
- Use of Animals to Study the Neurobiological Effects of Isolation (2019) (2)
- CHAPTER B3 – From Man to Mouse: The MPTP Model of Parkinson Disease (2005) (2)
- Numerous GABAergic Afferents to Locus Ceruleus in the Pericerulear Dendritic Zone : Possible (2004) (2)
- Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior Graphical (2016) (1)
- Temporal mRNA profiles of inflammatory mediators in the murine MPTP model of Parkinson’s disease (2007) (1)
- Research report I dentification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice (2003) (1)
- Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment (2022) (1)
- P3.067 Mice infected with highly pathogenic H5N1 influenza virus develop Parkinsonian pathology (2009) (0)
- Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation (2019) (0)
- Announcement Appointment of new Editors for all sections (2002) (0)
- 2.454 The immunosuppressant, 4-deoxypyridoxine (DOP), demonstrates novel neuroprotective effects in the acute MPTP model of Parkinson's disease (2007) (0)
- Regulation ofProto-Oncogene Expression inAdultand Developing Lungs (1993) (0)
- Neurobiological and Behavioral Characterization of Adult Male and Female Mice in Prolonged Social Isolation (2022) (0)
- 2.410 Is H5N1 influenza virus a novel etiological agent in the development of post-encephalitic parkinsonism? (2007) (0)
- 2.428 VEGF and angiogenesis in an animal model of Parkinson's disease (2007) (0)
- 3.243 INCREASING ENDOGENOUS NEUROGENESIS USING NEUROSTEROIDS: A NOVEL THERAPEUTIC STRATEGY TO TREAT PARKINSON'S DISEASE (2012) (0)
- T Cells + Decarboxylase-Specific CD4 Mediated by Glutamic Acid Central Nervous System Destruction (2010) (0)
- P1.006 Neurochemical and neuroplastic changes in chronic methyphenidate administered brains (2009) (0)
- bone marrow hematopoietic progenitor cells Functional amelioration of murine galactosialidosis by genetically modified (2013) (0)
- 2.17.2 INFLUENZA VIRUS AND PARKINSON'S DISEASE (2012) (0)
- Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism (2021) (0)
- P2.011 Effect of aging on SNpc neuron loss, striatal dopamine and genea expression in C57BL/6 and Swiss-Webster mice following MPTP administration (2009) (0)
- Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis (2017) (0)
- The impact of a neurogenic agent, allopregnanolone, in rodent models of Alzheimer's and Parkinson's disease (2011) (0)
- Methode permettant de determiner une sensibilite aux toxines mesologiques et la susceptibilite de developper la maladie de parkinson (2003) (0)
- Catalog of the Neurological Mutants of Mouse revisited: Honoring the 40th anniversary of its initial publication (2007) (0)
- 2.130 CHANGE IN GLUTATHIONE-S-TRANSFERASE-PI EXPRESSION IN BLOOD OF PARKINSON'S DISEASE PATIENTS FOLLOWING EXPOSURE TO OXIDATIVE STRESS: POTENTIAL USE AS A BIOMARKER (2012) (0)
- The role of nerve growth factor family receptors in the development of the mammalian nervous system (1994) (0)
- Effect of Long‐term Methylphenidate Treatment in a Female Experimental Model of Parkinsonism (2019) (0)
- CHAPTER 6:Glutathione and Thiol Redox Signalling in Parkinson’s Disease (2017) (0)
- A morphological analysis of neuronal changes induced by environmental enrichment (2003) (0)
- P3-473 THE IMPACT OFA NEUROGENIC AGENT, ALLOPREGNANOLONE, IN RODENTMODELS OF ALZHEIMER’S AND PARKINSON’S DISEASE (2019) (0)
- Gene Expression Patterns- a new journal in the Brain Research series (2001) (0)
- Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease (2022) (0)
- Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus (2018) (0)
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