Timothy Billiar

Timothy Billiar's AcademicInfluence.com Rankings

Timothy Billiar

Medical

#726

World Rank

#961

Historical Rank

Surgery

#40

World Rank

#61

Historical Rank

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Why Is Timothy Billiar Influential?

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According to Wikipedia, Timothy R. Billiar is an American surgeon currently the George Vance Foster Endowed Professor and Distinguished Professor of Surgery at University of Pittsburgh. His current research includes immune, cell and organ biology.

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Timothy Billiar's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genomic responses in mouse models poorly mimic human inflammatory diseases (2013) (2016)
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion (2005) (1112)
A genomic storm in critically injured humans (2011) (949)
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms* (1997) (905)
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand (2000) (896)
Inflammation, immunoregulation, and inducible nitric oxide synthase (1993) (895)
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. (1993) (840)
HMGB1: Endogenous Danger Signaling (2008) (722)
HMGB1 in health and disease. (2014) (703)
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. (1993) (674)
Nitrogen oxide levels in patients after trauma and during sepsis. (1991) (628)
The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity (2007) (617)
New insights into the regulation of inducible nitric oxide synthesis. (1994) (605)
HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling (2007) (602)
Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression* (1997) (563)
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. (1997) (545)
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury (2003) (535)
Nitric oxide as a bioregulator of apoptosis. (2001) (531)
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. (1998) (504)
Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock (1998) (489)
Nitric oxide as a bifunctional regulator of apoptosis. (1999) (465)
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. (1991) (460)
Linking oxidative stress to inflammation: Toll-like receptors. (2010) (459)
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. (1996) (453)
Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock (2018) (453)
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. (2017) (452)
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin (1992) (430)
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. (1998) (430)
Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene* (1998) (414)
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. (1994) (402)
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells (1989) (398)
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. (1996) (393)
Inducible Nitric Oxide Synthase and Inflammatory Diseases (2000) (392)
Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier (2006) (383)
Impaired wound healing and angiogenesis in eNOS-deficient mice. (1999) (378)
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. (1992) (376)
The regulatory role of nitric oxide in apoptosis. (2001) (375)
Masquerader: High Mobility Group Box-1 and Cancer (2007) (375)
Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells1 (2005) (374)
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. (1991) (367)
Nitric oxide and wound repair: role of cytokines? (2002) (334)
Endogenous Histones Function as Alarmins in Sterile Inflammatory Liver Injury Through Toll-like Receptor 9 in Mice (2011) (331)
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. (2009) (329)
Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury (2015) (327)
EMERGING PARADIGM: TOLL-LIKE RECEPTOR 4-SENTINEL FOR THE DETECTION OF TISSUE DAMAGE (2006) (321)
PKM2 Regulates the Warburg Effect and Promotes HMGB1 Release in Sepsis (2014) (320)
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. (2006) (306)
The Endotoxin Delivery Protein HMGB1 Mediates Caspase‐11‐Dependent Lethality in Sepsis (2018) (303)
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells (1998) (296)
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species (2007) (295)
Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling1 (2007) (293)
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation (2016) (286)
Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical‐mediated hepatic injury (1992) (285)
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. (2018) (278)
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. (2008) (272)
Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes* (1999) (270)
Molecular biology of nitric oxide synthases (1998) (268)
MD-2 is required for disulfide HMGB1–dependent TLR4 signaling (2015) (267)
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. (1997) (266)
High-mobility group box 1 is essential for mitochondrial quality control. (2011) (259)
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. (1990) (257)
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide. (1995) (255)
Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. (1997) (255)
Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. (2000) (254)
Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin‐6 by rat Kupffer cells (1993) (254)
Nitric Oxide Suppression of Apoptosis Occurs in Association with an Inhibition of Bcl-2 Cleavage and Cytochrome cRelease* (1998) (254)
Intra-Abdominal Activation of a Local Inflammatory Response Within the Human Muscularis Externa During Laparotomy (2003) (252)
The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase (1995) (250)
Role of Toll-Like Receptors in Changes in Gene Expression and NF-κB Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide (2002) (247)
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. (1998) (241)
Nitric Oxide Novel Biology with Clinical Relevance (1995) (240)
Application of genome-wide expression analysis to human health and disease. (2005) (240)
Platelet-derived HMGB1 is a critical mediator of thrombosis. (2015) (236)
Protection Against Ischemia/Reperfusion Injury in Cardiac and Renal Transplantation with Carbon Monoxide, Biliverdin and Both (2005) (235)
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. (2012) (234)
Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. (1990) (231)
Nitric oxide prevents tumor necrosis factor α–induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S‐nitrosylation of caspase‐8 (2000) (231)
Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling (1999) (229)
Cellular Non-heme Iron Content Is a Determinant of Nitric Oxide-mediated Apoptosis, Necrosis, and Caspase Inhibition* (2000) (228)
Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock (2006) (225)
Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression. (1997) (221)
Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production. (1994) (219)
Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. (2001) (218)
High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity* (2010) (217)
Nitric oxide and nitric oxide‐generating compounds inhibit hepatocyte protein synthesis (1991) (214)
Inducible nitric oxide synthase in the liver: regulation and function. (1998) (212)
Systemic inflammation and remote organ injury following trauma require HMGB1. (2007) (212)
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. (2001) (209)
Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1 (2003) (208)
Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. (2000) (208)
THE ACUTE INFLAMMATORY RESPONSE IN DIVERSE SHOCK STATES (2005) (206)
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics (2014) (202)
Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production* (2001) (193)
IV. Determinants of nitric oxide protection and toxicity in liver. (1999) (191)
A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis* (1999) (189)
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury (2013) (182)
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. (1995) (179)
Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia (1992) (177)
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. (2014) (176)
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. (1998) (175)
High‐mobility group box‐1 in sterile inflammation (2014) (174)
Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. (2004) (174)
LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. (1999) (173)
Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis. (1997) (168)
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells. (2004) (168)
Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis (2014) (168)
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling (2013) (166)
Nitric oxide prevents 6‐hydroxydopamine‐induced apoptosis in PC12 cells through cGMP‐dependent PI3 kinase/Akt activation (2003) (163)
Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type–Specific Functions of TLR4 during Sepsis (2013) (163)
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. (2005) (162)
Nitric Oxide Prevents IL-1β and IFN-γ-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1β-Converting Enzyme) (1998) (162)
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy* (2016) (161)
Oral hydrogen water prevents chronic allograft nephropathy in rats. (2010) (160)
Inducible nitric oxide synthase and vascular injury. (1999) (156)
Role of nitric oxide in liver injury. (2003) (156)
Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14 (2013) (155)
Nitric oxide, a protective molecule in the cardiovascular system. (2013) (154)
Carbon monoxide reverses established pulmonary hypertension (2006) (152)
Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. (1995) (152)
A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis. (1995) (151)
Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells (2011) (150)
Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. (1992) (144)
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. (2015) (143)
Molecular mechanisms in the early phase of hemorrhagic shock (2001) (142)
Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP. (1989) (140)
Inflammasome and Autophagy Regulation: A Two-way Street (2017) (139)
Pre-trauma center red blood cell transfusion is associated with improved early outcomes in air medical trauma patients. (2015) (138)
Nitric‐oxide production by murine mammary adenocarcinoma cells promotes tumor‐cell invasiveness (1999) (138)
Novel roles of nitric oxide in hemorrhagic shock. (1999) (137)
Neuronal NOS‐mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury (2006) (137)
Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure. (2019) (135)
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. (2013) (134)
Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver. (1999) (132)
Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. (1997) (132)
Early events in the recognition of danger signals after tissue injury (2008) (128)
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice (1999) (128)
Enhanced Oxidative Stress in iNOS-Deficient Mice after Traumatic Brain Injury: Support for a Neuroprotective Role of iNOS (2005) (127)
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. (2001) (127)
Increasing numbers of hepatic dendritic cells promote HMGB1‐mediated ischemia‐reperfusion injury (2007) (126)
Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis* (2014) (126)
Peroxisomal localization of inducible nitric oxide synthase in hepatocytes (2002) (124)
Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis. (2001) (124)
Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway1 (2004) (122)
Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury1 (2006) (122)
Cyclic Nucleotides Suppress Tumor Necrosis Factor α-Mediated Apoptosis by Inhibiting Caspase Activation and Cytochrome cRelease in Primary Hepatocytes via a Mechanism Independent of Akt Activation* (2000) (120)
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols. (2007) (120)
Hepatocyte‐specific high‐mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high‐mobility group box 1 in cellular protection (2014) (120)
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate. (2000) (119)
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. (2006) (117)
Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration. (1992) (117)
Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo. (1991) (115)
Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: When a little goes a long way (2012) (115)
Management of blunt splenic trauma: significant differences between adults and children. (1997) (115)
Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans. (2016) (114)
Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53 (2004) (114)
Nonheme iron-nitrosyl complex formation in rat hepatocytes: detection by electron paramagnetic resonance spectroscopy. (1993) (114)
Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway. (2000) (114)
IN SILICO MODELS OF ACUTE INFLAMMATION IN ANIMALS (2006) (114)
Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. (1996) (113)
Expression of CD14 by Hepatocytes: Upregulation by Cytokines during Endotoxemia (1998) (113)
Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. (1994) (113)
Sepsis: Something old, something new, and a systems view. (2012) (111)
The roles of iNOS in liver ischemia-reperfusion injury. (2001) (111)
Cellular‐specific role of toll‐like receptor 4 in hepatic ischemia‐reperfusion injury in mice (2013) (110)
Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes. (1992) (110)
Therapeutic Antioxidant Medical Gas (2008) (110)
Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats (2010) (109)
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. (2010) (108)
IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo (2004) (107)
Apoptosis in sepsis. (2000) (106)
Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response. (1994) (105)
Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling (2013) (103)
Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia (1996) (103)
Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart (2009) (102)
Dexamethasone suppresses iNOS gene expression by upregulating I-κBα and inhibiting NF-κB. (1997) (101)
Cell Death and DAMPs in Acute Pancreatitis (2014) (101)
TLR4/MyD88-Induced CD11b+Gr-1intF4/80+ Non-Migratory Myeloid Cells Suppress Th2 Effector Function in the Lung (2010) (101)
Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. (1995) (101)
A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States (2012) (101)
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. (1998) (101)
Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial. (2019) (100)
Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin (1994) (100)
Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer (2017) (99)
Systolic blood pressure criteria in the National Trauma Triage Protocol for geriatric trauma: 110 is the new 90 (2015) (99)
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice. (1999) (99)
β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes* (2008) (99)
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. (2006) (98)
CARBON MONOXIDE PREVENTS MULTIPLE ORGAN INJURY IN A MODEL OF HEMORRHAGIC SHOCK AND RESUSCITATION (2005) (98)
iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018) (98)
Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice (2013) (97)
TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism (2016) (97)
A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks (2011) (95)
Male gender is associated with excessive IL-6 expression following severe injury. (2008) (94)
Kupffer cell:hepatocyte cocultures release nitric oxide in response to bacterial endotoxin. (1990) (93)
Calcium/Calmodulin-Dependent Protein Kinase (CaMK) IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 during Lipopolysaccharide Stimulation of Macrophages1 (2008) (93)
Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments. (2004) (92)
Not all prehospital time is equal: Influence of scene time on mortality (2016) (92)
Induction of nitric oxide synthesis and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS. (1993) (92)
The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury (2014) (92)
Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. (2004) (92)
Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia. (2001) (91)
Debunking the survival bias myth: Characterization of mortality during the initial 24 hours for patients requiring massive transfusion (2012) (90)
Hydrogen inhalation ameliorates ventilator-induced lung injury (2010) (89)
High Mobility Group Box 1 Contributes to the Pathogenesis of Experimental Pulmonary Hypertension via Activation of Toll-like Receptor 4 (2012) (89)
Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. (2005) (89)
Tumor necrosis factor‐α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia (1994) (89)
Regulation of Posttranslational Modifications of HMGB1 During Immune Responses. (2016) (88)
Application of Heme Oxygenase-1, Carbon Monoxide and Biliverdin for the Prevention of Intestinal Ischemia/Reperfusion Injury (2008) (88)
Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures (2012) (88)
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis (2018) (88)
TMEM173 Drives Lethal Coagulation in Sepsis. (2020) (88)
Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). (1998) (87)
Effect of nitric oxide on heme metabolism in pulmonary artery endothelial cells. (1996) (87)
Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide. (2002) (87)
Leukocyte-Derived Inducible Nitric Oxide Synthase Mediates Murine Postoperative Ileus (2006) (87)
Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion (2007) (87)
Nitric oxide and wound repair. (2003) (86)
Nitric oxide and prostaglandins interact to prevent hepatic damage during murine endotoxemia. (1994) (86)
Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial. (2020) (85)
ALK is a therapeutic target for lethal sepsis (2017) (85)
HMGB1 as a potential biomarker and therapeutic target for severe COVID-19 (2020) (85)
PATTERNS OF CYTOKINE RELEASE AND EVOLUTION OF REMOTE ORGAN DYSFUNCTION AFTER BILATERAL FEMUR FRACTURE (2008) (85)
Antioxidant enzymes suppress nitric oxide production through the inhibition of NF-kappa B activation: role of H(2)O(2) and nitric oxide in inducible nitric oxide synthase expression in macrophages. (2001) (85)
A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. (1999) (84)
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. (2006) (84)
Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes (1995) (84)
THE ROLE OF INITIAL TRAUMA IN THE HOST'S RESPONSE TO INJURY AND HEMORRHAGE: INSIGHTS FROM A CORRELATION OF MATHEMATICAL SIMULATIONS AND HEPATIC TRANSCRIPTOMIC ANALYSIS (2006) (84)
Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury (2005) (84)
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow‐derived cells and parenchymal cells (2008) (83)
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling‐1–dependent mechanism (2009) (83)
Role of lipopolysaccharide (LPS), interleukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats (1995) (83)
Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. (2006) (82)
Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies (2013) (82)
The anti-apoptotic actions of nitric oxide in hepatocytes (1999) (82)
Location is the key to function: HMGB1 in sepsis and trauma‐induced inflammation (2019) (81)
Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis. (1998) (81)
Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma. (2015) (80)
Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. (2004) (79)
In Silico and In Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice (2006) (78)
EVIDENCE THAT NITRIC OXIDE PRODUCTION BY IN VIVO ALLOSENSITIZED CELLS INHIBITS THE DEVELOPMENT OF ALLOSPECIFIC CTL (1992) (78)
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (2002) (77)
Heat shock response inhibits cytokine‐inducible nitric oxide synthase expression in rat hepatocytes (1996) (77)
Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation. (1993) (76)
Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury (2009) (76)
The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury? (2017) (76)
Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis. (2003) (75)
Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis‐Induced Liver Injury by Granisetron Generation in Mice (2019) (75)
Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro. (1995) (74)
Trauma in silico: Individual-specific mathematical models and virtual clinical populations (2015) (74)
Angiotensin-Converting Enzyme Inhibitor Preserves p21 and Endothelial Nitric Oxide Synthase Expression in Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats (2001) (74)
A brief episode of hypotension increases mortality in critically ill trauma patients. (2002) (74)
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model (2017) (73)
Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes. (2008) (73)
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. (2017) (73)
Interferon Regulatory Factor 1 Mediates Acetylation and Release of High Mobility Group Box 1 from Hepatocytes During Murine Liver Ischemia-Reperfusion Injury (2011) (73)
Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production. (2010) (73)
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine* (2012) (73)
Evolving role of endovascular techniques for traumatic vascular injury: A changing landscape? (2012) (72)
Evolution of management of major hepatic trauma: identification of patterns of injury. (1995) (72)
Trauma center maturation: quantification of process and outcome. (1999) (72)
Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells (2001) (71)
Nitric oxide production is inhibited in trauma patients. (1993) (71)
Parenteral calcium for intensive care unit patients. (2008) (70)
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. (2009) (70)
Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury. (2011) (69)
Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress* (2013) (69)
Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism. (1991) (69)
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis. (1997) (69)
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock. (2006) (69)
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IκB (2004) (69)
Adenoviral Gene Transfer of the Human Inducible Nitric Oxide Synthase Gene Enhances the Radiation Response of Human Colorectal Cancer Associated with Alterations in Tumor Vascularity (2004) (69)
Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. (2000) (68)
Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance (2008) (68)
Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. (1998) (68)
Hypoxia Inhibits Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Blocking Bax Translocation (2004) (68)
Hospital-acquired pneumonia is an independent predictor of poor global outcome in severe traumatic brain injury up to 5 years after discharge (2015) (68)
Inhibition of Protein Synthesis by Nitric Oxide Correlates with Cytostatic Activity: Nitric Oxide Induces Phosphorylation of Initiation Factor eIF-2α (1998) (68)
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis (2019) (68)
Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver During Hemorrhagic Shock (2003) (67)
Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock. (2000) (67)
Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. (1994) (67)
Gene therapy for restenosis. (2000) (66)
Inhaled nitric oxide in congenital diaphragmatic hernia. (1994) (66)
TISSUE HYPOXIA ACTIVATES JNK IN THE LIVER DURING HEMORRHAGIC SHOCK (2004) (66)
PHYSIOLOGIC AND MOLECULAR CHARACTERIZATION OF THE ROLE OF NITRIC OXIDE IN HEMORRHAGIC SHOCK: EVIDENCE THAT TYPE II NITRIC OXIDE SYNTHASE DOES NOT REGULATE VASCULAR DECOMPENSATION (1997) (66)
Goal‐directed resuscitation in the prehospital setting: A propensity‐adjusted analysis (2013) (66)
Innate immune mechanisms in ischemia/reperfusion. (2009) (65)
Mechanisms of Hepatoprotection by Nitric Oxide (2002) (65)
Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation. (2015) (65)
Helicopter transport improves survival following injury in the absence of a time-saving advantage. (2016) (64)
Nitric Oxide Induces Angiogenesis and Upregulates αvβ3 Integrin Expression on Endothelial Cells (2000) (64)
Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality* (2016) (63)
The effect of nitric oxide on fetal pulmonary artery smooth muscle growth. (1995) (63)
Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents (2016) (63)
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis (2016) (63)
Changes in massive transfusion over time: An early shift in the right direction? (2012) (62)
cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING. (2018) (62)
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut (2015) (62)
Maltose absorption as an indicator of small-intestinal allograft rejection. (1984) (62)
Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. (2005) (61)
G‐CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia (1998) (61)
The role of nitric oxide in Kupffer cell-hepatocyte interactions. (1995) (61)
A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion. (2002) (61)
Liver nonparenchymal cells are stimulated to provide interleukin 6 for induction of the hepatic acute-phase response in endotoxemia but not in remote localized inflammation. (1992) (60)
IFN-? enhances TRAIL-induced apoptosis through IRF-1: IFN-? enhances TRAIL-induced apoptosis (2004) (60)
INHIBITION OF NITRIC OXIDE SYNTHESIS DURING SEVERE SHOCK BUT NOT AFTER RESUSCITATION INCREASES HEPATIC INJURY AND NEUTROPHIL ACCUMULATION IN HEMORRHAGED RATS (1995) (60)
Effects of hemodilution on long-term survival in an uncontrolled hemorrhagic shock model in rats. (1997) (60)
The delicate balance of nitric oxide and superoxide in liver pathology. (1995) (60)
The hepatocyte as a microbial product-responsive cell (2001) (60)
LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling (2020) (60)
In Silico Modeling: Methods and Applications to Trauma and Sepsis (2013) (59)
Cancer gene therapy using a novel secretable trimeric TRAIL (2006) (59)
Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs (2014) (59)
Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps (2015) (59)
Liver injury during sepsis. (1995) (58)
Hemorrhagic shock. (1995) (58)
An Adequately Robust Early TNF-α Response Is a Hallmark of Survival Following Trauma/Hemorrhage (2009) (57)
Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling (2015) (57)
Tissue damage negatively regulates LPS-induced macrophage necroptosis (2016) (57)
Genetic Deletion of Toll-Like Receptor 4 on Platelets Attenuates Experimental Pulmonary Hypertension (2014) (57)
The effect of donor treatment with hydrogen on lung allograft function in rats. (2011) (55)
Intestinal Gram‐negative Bacterial Overgrowth In Vivo Augments the In Vitro Response of Kupffer Cells to Endotoxin (1988) (55)
IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. (2019) (55)
HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4 (2015) (55)
The swinging pendulum: A national perspective of nonoperative management in severe blunt liver injury (2013) (55)
Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma (2015) (55)
Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. (1997) (55)
Roles of Nitric Oxide in Surgical Infection and Sepsis (1998) (54)
Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury (2020) (54)
Toll-like Receptor 4 (TLR4) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling (2015) (54)
Acute traumatic coagulopathy in a critically injured pediatric population: Definition, trend over time, and outcomes (2016) (54)
Complement C3 Deficiency Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in Mice (2011) (54)
Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy. (2012) (54)
Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation. (1994) (54)
Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis (2018) (54)
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. (2008) (54)
TLR4 Signaling Augments Monocyte Chemotaxis by Regulating G Protein–Coupled Receptor Kinase 2 Translocation (2013) (53)
The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock (2002) (52)
Nitric Oxide and Inflammation (2012) (52)
The Tumor Suppressor p 53 Limits Ferroptosis by Blocking DPP 4 Activity (2018) (52)
Ischemic preconditioning of the murine liver protects through the Akt kinase pathway (2006) (52)
The secretable form of trimeric TRAIL, a potent inducer of apoptosis. (2004) (52)
Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP (2006) (52)
Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric Function During Transplantation (2011) (52)
Caspase-1 Is Hepatoprotective during Trauma and Hemorrhagic Shock by Reducing Liver Injury and Inflammation (2011) (51)
Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells. (1996) (51)
Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. (1993) (51)
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. (2016) (51)
Inducible Protein-10, a Potential Driver of Neurally Controlled Interleukin-10 and Morbidity in Human Blunt Trauma* (2014) (51)
Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis. (2000) (51)
Neutrophils Counteract Autophagy-Mediated Anti-Inflammatory Mechanisms in Alveolar Macrophage: Role in Posthemorrhagic Shock Acute Lung Inflammation (2014) (51)
Glutathione regulates nitric oxide synthase in cultured hepatocytes. (1997) (51)
Computed tomography abbreviated assessment of sarcopenia following trauma: The CAAST measurement predicts 6-month mortality in older adult trauma patients (2016) (51)
Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. (2011) (51)
Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties. (2021) (50)
Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans* (2015) (50)
Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow following Hemorrhagic Shock1 (2009) (50)
The Impact of Liver Dysfunction on Outcome in Patients with Multiple Injuries (2001) (49)
Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence. (2007) (49)
Aging‐related Atg5 defect impairs neutrophil extracellular traps formation (2017) (49)
The Role of Fracture-Associated Soft Tissue Injury in the Induction of Systemic Inflammation and Remote Organ Dysfunction After Bilateral Femur Fracture (2008) (49)
Endovascular Repair of an Aortoduodenal Fistula (2000) (48)
Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial (2015) (48)
A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes* (2012) (48)
Precision Medicine for Critical Illness and Injury (2016) (48)
Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients. (2016) (48)
IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury. (2020) (48)
RhoA Influences the Nuclear Localization of Extracellular Signal–Regulated Kinases to Modulate p21Waf/Cip1 Expression (2003) (47)
High Mobility Group Box 1 Inhibits Human Pulmonary Artery Endothelial Cell Migration via a Toll-like Receptor 4- and Interferon Response Factor 3-dependent Mechanism(s)* (2012) (47)
Role of Heme Oxygenase 1 in TNF/TNF Receptor–Mediated Apoptosis After Hepatic Ischemia/Reperfusion in Rats (2013) (47)
Role of the IL-33-ST2 axis in sepsis (2017) (47)
Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. (1994) (46)
Kupffer cell cytotoxicity to hepatocytes in coculture requires L-arginine. (1989) (46)
High mobility group protein B1 controls liver cancer initiation through yes‐associated protein ‐dependent aerobic glycolysis (2018) (46)
Delay to therapeutic interventional radiology postinjury: time is of the essence. (2010) (46)
The role of type 1 interferons in coagulation induced by gram-negative bacteria (2020) (46)
Hemorrhagic Shock Augments Nlrp3 Inflammasome Activation in the Lung through Impaired Pyrin Induction (2013) (46)
Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS-Stimulated Macrophages through Nitric Oxide (2012) (45)
IFN-gamma enhances TRAIL-induced apoptosis through IRF-1. (2004) (45)
Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism. (2003) (45)
Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis. (1989) (45)
Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells. (1996) (45)
Injury‐induced MRP8/MRP14 stimulates IP‐10/CXCL10 in monocytes/macrophages (2015) (45)
Risk factors for survival following surgical treatment of traumatic aortic rupture. (1985) (45)
A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogeneic immune response. (1992) (45)
Hypothermia in massive transfusion: Have we been paying enough attention to it? (2012) (44)
Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation (2014) (44)
Maternity policy and practice during surgery residency: how we do it. (2002) (44)
Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B. (1997) (44)
Nitric Oxide Suppresses the Expression of Bcl-2 Binding Protein BNIP3 in Hepatocytes* (2001) (44)
Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy. (2016) (44)
Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells. (2003) (44)
Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice. (2018) (43)
Toll-Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide From Bacterial Outer Membrane Vesicles (2018) (43)
Review: Nitric Oxide, Sepsis, and Arginine Metabolism: (1995) (43)
HMGB 1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis (2017) (43)
LOCAL EXPOSURE OF BONE COMPONENTS TO INJURED SOFT TISSUE INDUCES TOLL-LIKE RECEPTOR 4-DEPENDENT SYSTEMIC INFLAMMATION WITH ACUTE LUNG INJURY (2008) (42)
Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury* (2015) (42)
Anti-HMGB 1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock (2006) (42)
Hemorrhagic shock induces G-CSF expression in bronchial epithelium. (1997) (42)
Benzyl alcohol attenuates acetaminophen‐induced acute liver injury in a Toll‐like receptor‐4‐dependent pattern in mice (2014) (42)
Decreased activity of inducible nitric oxide synthase type 2 and modulation of the expression of glutathione S-transferase alpha, bcl-2, and metallothioneins during the differentiation of CaCo-2 cells. (1997) (42)
A novel method of preserving cardiac grafts using a hydrogen-rich water bath. (2013) (41)
Impaired Gut Contractility Following Hemorrhagic Shock is Accompanied by IL-6 and G-CSF Production and Neutrophil Infiltration (2001) (41)
Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions (2017) (41)
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. (2012) (41)
WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. (2012) (41)
Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock (2001) (40)
A cohort of supporting metabolic enzymes is coinduced with nitric oxide synthase in human tumor cell lines. (1996) (40)
Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury (2020) (40)
A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock (2002) (40)
IFN-γ Inhibition of TRAIL-Induced IAP-2 Upregulation, a Possible Mechanism of IFN-γ-Enhanced TRAIL-Induced Apoptosis☆☆☆ (2002) (40)
Nitric oxide: A clinical primer (2005) (40)
Nitrite Reduces Acute Lung Injury and Improves Survival in a Rat Lung Transplantation Model (2012) (40)
Toll-Like Receptors and Myocardial Ischemia/Reperfusion, Inflammation, and Injury (2009) (40)
Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes. (2016) (39)
HEPATOCYTES ENHANCE EFFECTS OF LIPOPOLYSACCHARIDE ON LIVER NONPARENCHYMAL CELLS THROUGH CLOSE CELL INTERACTIONS (2005) (39)
Systemic Inflammation and Liver Injury Following Hemorrhagic Shock and Peripheral Tissue Trauma Involve Functional TLR9 Signaling on Bone Marrow-Derived Cells and Parenchymal Cells (2011) (39)
Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk? (2011) (39)
Speed is not everything: Identifying patients who may benefit from helicopter transport despite faster ground transport (2017) (39)
The Protective Effect of PNU-282987, a Selective &agr;7 Nicotinic Acetylcholine Receptor Agonist, on the Hepatic Ischemia-Reperfusion Injury Is Associated With the Inhibition of High-Mobility Group Box 1 Protein Expression and Nuclear Factor &kgr;B Activation in Mice (2013) (39)
Development and Validation of the Air Medical Prehospital Triage Score for Helicopter Transport of Trauma Patients (2016) (39)
A NOVEL INHIBITORY PEPTIDE OF TOLL-LIKE RECEPTOR SIGNALING LIMITS LIPOPOLYSACCHARIDE-INDUCED PRODUCTION OF INFLAMMATORY MEDIATORS AND ENHANCES SURVIVAL IN MICE (2007) (39)
Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes. (2020) (39)
Cytokine induction of interferon regulatory factor-1 in hepatocytes. (1993) (38)
Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages (2018) (38)
Helicopters and injured kids: Improved survival with scene air medical transport in the pediatric trauma population (2016) (38)
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Prehospital plasma is associated with distinct biomarker expression following injury. (2020) (38)
The effects of administration of nitric oxide inhibitors during small bowel preservation and reperfusion. (1994) (38)
Counterprotective effect of erythrocytes in experimental bacterial peritonitis is due to scavenging of nitric oxide and reactive oxygen intermediates (1996) (37)
Lipopolysaccharide Stimulates p62-Dependent Autophagy-Like Aggregate Clearance in Hepatocytes (2014) (37)
Hepatocyte Injury by Activated Neutrophils In Vitro Is Mediated by Proteases (1993) (37)
Heme oxygenase‐1: A cellular Hercules (2003) (37)
Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density. (1994) (37)
Role of hemorrhage in the induction of systemic inflammation and remote organ damage: Analysis of combined pseudo‐fracture and hemorrhagic shock (2011) (37)
Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes. (2008) (37)
Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor. (2009) (36)
TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury (2017) (36)
The role of nitric oxide in apoptosis. (2000) (36)
Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management. (2010) (36)
UTILITY OF CLINICAL PARAMETERS OF TISSUE OXYGENATION IN A QUANTITATIVE MODEL OF IRREVERSIBLE HEMORRHAGIC SHOCK (1998) (36)
Nitric oxide causes hyporeactivity to phenylephrine in isolated perfused livers from endotoxin-treated rats. (1995) (36)
Vascular inducible nitric oxide synthase gene therapy: requirement for guanosine triphosphate cyclohydrolase I. (1996) (36)
Possible Novel Therapy for Malignant Gliomas with Secretable Trimeric TRAIL (2009) (36)
Cyclic GMP and guanylate cyclase mediate lipopolysaccharide‐induced Kupffer cell tumor necrosis factor‐α synthesis (1995) (35)
Estrogen sulfotransferase ablation sensitizes mice to sepsis (2015) (35)
Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. (2002) (35)
Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury. (2015) (35)
EARLY GROWTH RESPONSE 1 MEDIATES THE SYSTEMIC AND HEPATIC INFLAMMATORY RESPONSE INITIATED BY HEMORRHAGIC SHOCK (2007) (35)
Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening (2013) (35)
Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine‐polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms (2010) (35)
The role of hepatic type 1 plasminogen activator inhibitor (PAI‐1) during murine hemorrhagic shock (2005) (35)
Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. (2009) (34)
High Mobility Group Box 1 (HMGB1) Phenotypic Role Revealed with Stress (2014) (34)
Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress (2021) (34)
American College of Surgeons trauma center verification versus state designation: Are Level II centers slipping through the cracks? (2013) (34)
Splenocyte Apoptosis and Autophagy Is Mediated by Interferon Regulatory Factor 1 During Murine Endotoxemia (2012) (34)
Sepsis and exogenous lipid modulation. (1988) (34)
Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma (2017) (34)
WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury (2016) (34)
Kupffer cell and hepatocyte interactions: a brief overview. (1990) (34)
Sources of arginine for induced nitric oxide synthesis in the isolated perfused liver. (1995) (34)
ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes. (2015) (34)
Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level (2016) (34)
Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury (2018) (33)
Antisense oligodeoxynucleotide to inducible nitric oxide synthase inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture. (1993) (33)
Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. (2015) (33)
Cytokine-induced changes in chromatin structure and in vivo footprints in the inducible NOS promoter. (2001) (33)
Interferon regulatory factor 1–Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury (2018) (33)
Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells. (2000) (33)
Competition for Tetrahydrobiopterin between Phenylalanine Hydroxylase and Nitric Oxide Synthase in Rat Liver* (1996) (33)
The research agenda for trauma critical care (2017) (32)
Cysteine 230 modulates tumor necrosis factor-related apoptosis-inducing ligand activity. (2000) (32)
Characterization of acute coagulopathy and sexual dimorphism after injury: Females and coagulopathy just do not mix (2012) (32)
Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling (2020) (32)
Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway (2019) (32)
Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors. (2000) (32)
ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury (2016) (32)
Mast cells play a critical role in the systemic inflammatory response and end-organ injury resulting from trauma. (2011) (32)
Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria (2017) (32)
A Potential Role for Nitric Oxide in Myocardial Stunning (1994) (31)
HYPOXIA ACTIVATES c-JUN N-TERMINAL KINASE VIA RAC1-DEPENDENT REACTIVE OXYGEN SPECIES PRODUCTION IN HEPATOCYTES (2007) (31)
NEUTROPHIL NAD(P)H OXIDASE IS REQUIRED FOR HEMORRHAGIC SHOCK-ENHANCED TLR2 UP-REGULATION IN ALVEOLAR MACROPHAGES IN RESPONSE TO LPS (2007) (31)
Inducible Nitric Oxide Synthase: From Cloning to Therapeutic Applications (2002) (31)
Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (2008) (31)
TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release. (2013) (31)
Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway. (2006) (31)
Geographic distribution of trauma centers and injury-related mortality in the United States (2016) (31)
Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1 (2015) (31)
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. (2011) (30)
Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury (2018) (30)
Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome. (2010) (30)
Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts. (1999) (30)
DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. (2011) (30)
Role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock. (1998) (30)
Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. (2011) (30)
Models of lower extremity damage in mice: time course of organ damage and immune response. (2011) (29)
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RNA Editing, ADAR1, and the Innate Immune Response (2017) (29)
Impact of Volume Change Over Time on Trauma Mortality in the United States (2017) (29)
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells. (2002) (29)
Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion (2014) (29)
The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE (2013) (29)
Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor–mediated toxicity (2005) (29)
Hepatic inducible nitric oxide synthase: regulation and function. (1995) (29)
Autologous Reconstruction and Visceral Transplantation for Management of Patients With Gut Failure After Bariatric Surgery: 20 Years of Experience. (2015) (29)
Regulation of constitutive nitric oxide synthase activity by the human heart. (1995) (28)
Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes. (2000) (28)
Nitric oxide induces angiogenesis and upregulates alpha(v)beta(3) integrin expression on endothelial cells. (2000) (28)
Resolving the nitric oxide paradox in acute tissue damage. (1997) (28)
Glucagon inhibits hepatocyte nitric oxide synthesis. (1996) (27)
Increased nitric oxide production by airway cells of sensitized and challenged IL‐10 knockout mice (2001) (27)
Changes in FADD levels, distribution, and phosphorylation in TNFα-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent (2008) (27)
Delayed Neutralization of Interleukin 6 Reduces Organ Injury, Selectively Suppresses Inflammatory Mediator, and Partially Normalizes Immune Dysfunction Following Trauma and Hemorrhagic Shock (2014) (27)
TLR4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 (TLR2) in Ischemic Skeletal Muscle and Endothelial Cells (2015) (27)
Pro- and Anti-Apoptotic Effects of Nitric Oxide in Irradiated Keratinocytes: The Role of Superoxide (2002) (27)
Hepatocyte Fas-associating Death Domain Protein/Mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli* (2002) (27)
Excessive NO production dose not account for the inhibition of hepatic gluconeogenesis in endotoxemia. (1996) (27)
Remote tissue injury primes hepatocytes for nitric oxide synthesis. (1994) (27)
Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. (1998) (27)
TRISS unexpected survivors: an outdated standard? (1999) (27)
Surgical rescue: The next pillar of acute care surgery (2017) (27)
Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2 (2016) (27)
Nitric oxide‐mediated inhibition of caspase‐dependent T lymphocyte proliferation (2003) (27)
Gene therapy and tissue engineering. (1999) (27)
GTP cyclohydrolase I is coinduced in hepatocytes stimulated to produce nitric oxide. (2000) (26)
External validation of the Air Medical Prehospital Triage score for identifying trauma patients likely to benefit from scene helicopter transport (2017) (26)
Retracted: Redox‐dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice (2016) (26)
Modulation of Kupffer cell membrane phospholipid function by n-3 polyunsaturated fatty acids. (1989) (26)
X Chromosome-Linked IRAK-1 Polymorphism Is a Strong Predictor of Multiple Organ Failure and Mortality Postinjury (2014) (26)
Redefining acute care surgery: Surgical rescue. (2015) (26)
Low‐dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality (2009) (26)
Effects of hepatocellular mitogens on cytokine‐induced nitric oxide synthesis in human hepatocytes (1996) (26)
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. (1998) (26)
TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway. (2019) (26)
Evidence-based improvement of the National Trauma Triage Protocol: The Glasgow Coma Scale versus Glasgow Coma Scale motor subscale (2014) (26)
Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma? (2018) (25)
Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury. (2019) (25)
Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis. (2016) (25)
Prostanoids inhibit Kupffer cell nitric oxide synthesis. (1995) (25)
CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. (2016) (25)
Eritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma. (2013) (25)
Efficacy of inhaled nitric oxide in oleic acid-induced acute lung injury. (1997) (25)
Impaired wound healing and angiogenesis in eNOS-deficient mice. (1999) (25)
Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients (2016) (25)
Inducible Nitric Oxide Synthase Contributes to Immune Dysfunction Following Trauma (2012) (25)
IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis. (2002) (25)
The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury (2015) (24)
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis (2019) (24)
Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells. (2010) (24)
Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock (2012) (24)
Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. (2011) (24)
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock (2011) (24)
Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes. (2011) (24)
Principal component analysis of coagulation assays in severely injured children (2017) (24)
Racial disparities and sex-based outcomes differences after severe injury. (2012) (24)
Catecholamines decrease nitric oxide production by cytokine-stimulated hepatocytes. (2001) (23)
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells (2009) (23)
Cumulative Effects of Bone and Soft Tissue Injury on Systemic Inflammation: A Pilot Study (2013) (23)
Emerging mechanisms of immunocoagulation in sepsis and septic shock. (2021) (23)
Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation (2020) (23)
Characterization of Sex Dimorphism Following Severe Thermal Injury (2014) (22)
cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes. (2012) (22)
Geographic Variation in Outcome Benefits of Helicopter Transport for Trauma in the United States: A Retrospective Cohort Study (2016) (22)
Give me iNOS or give me death (2001) (22)
Cyclosporine-induced hepatotoxicity: a microassay by hepatocytes in tissue culture. (1988) (22)
Nitric oxide production after acute, unilateral hydrochloric acid-induced lung injury in a canine model. (1998) (22)
A Critical Role for IFN Regulatory Factor 1 in NKT Cell-Mediated Liver Injury Induced by α-Galactosylceramide (2010) (22)
Hemodynamic effects and metabolic fate of inhaled nitric oxide in hypoxic piglets. (1994) (22)
Studies toward the analysis of S-nitrosoproteins. (2009) (22)
Frontline Science: Macrophage‐derived exosomes promote neutrophil necroptosis following hemorrhagic shock (2017) (22)
Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. (2008) (22)
Mammalian DNA Is an Endogenous Danger Signal That Stimulates Local Synthesis and Release of Complement Factor B (2012) (22)
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. (2009) (22)
Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury (2013) (21)
The HIV Protease Inhibitor Saquinavir Inhibits HMGBl-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88 (2015) (21)
A road map from single-cell transcriptome to patient classification for the immune response to trauma (2020) (21)
Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury (2017) (21)
Prehospital Use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Is Associated With a Reduced Incidence of Trauma-Induced Coagulopathy (2014) (21)
Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice (2013) (21)
PGE2 and LTB4 inhibit cytokine-stimulated nitric oxide synthase type 2 expression in isolated rat hepatocytes. (1996) (21)
Gene therapy and vascular disease. (1999) (21)
Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression. (2013) (21)
Interleukin‐33 contributes to ILC2 activation and early inflammation‐associated lung injury during abdominal sepsis (2018) (21)
Differential regulation by fucoidan of IFN‐γ‐induced NO production in glial cells and macrophages (2010) (21)
Factors Associated With Nontransfer in Trauma Patients Meeting American College of Surgeons’ Criteria for Transfer at Nontertiary Centers (2017) (20)
Activation of latent transforming growth factor‐β1 by nitric oxide in macrophages: Role of soluble guanylate cyclase and MAP kinases (2009) (20)
HMGB1 released from nociceptors mediates inflammation (2021) (20)
Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. (2012) (20)
Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury. (2012) (20)
Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock (1998) (20)
Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2. (2008) (20)
Nitric oxide, sepsis, and arginine metabolism. (1995) (20)
Nitric oxide and the surgical patient. Identifying therapeutic targets. (1997) (20)
Neutrophil accumulation and damage to the gastric mucosa in resuscitated hemorrhagic shock is independent of inducible nitric oxide synthase. (1999) (20)
Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis. (2011) (20)
Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury. (2011) (19)
Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction (2019) (19)
Oxygen supply dependence of urea production in the isolated perfused rat liver. (1998) (19)
Orally administered nitrite attenuates cardiac allograft rejection in rats. (2009) (19)
Nitric oxide produced by cytokine-activated pulmonary artery smooth muscle cells is cytotoxic to cocultured endothelium. (1996) (19)
NO and COX2: Dual targeting for aggressive cancers (2017) (19)
N-tert-butylmethanimine N-oxide is an efficient spin-trapping probe for EPR analysis of glutathione thiyl radical (2016) (19)
Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation (2017) (19)
Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis. (1993) (19)
An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma (2017) (19)
Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries (2019) (19)
Comparing the Air Medical Prehospital Triage Score With Current Practice for Triage of Injured Patients to Helicopter Emergency Medical Services: A Cost-effectiveness Analysis (2017) (18)
Sepsis Upregulates CD14 Expression in a MyD88-Dependent and Trif-Independent Pathway (2018) (18)
Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization* (2002) (18)
Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. (2010) (18)
Practice-based learning and improvement: a two-year experience with the reporting of morbidity and mortality cases by general surgery residents. (2012) (18)
RAGE-induced ILC2 expansion in acute lung injury due to haemorrhagic shock (2020) (18)
Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 (2012) (18)
Regulation and functions of nitric oxide in the liver in sepsis and inflammation. (1995) (18)
Risk factors for the development of renal failure following the surgical treatment of traumatic aortic rupture. (1987) (17)
Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors? (2011) (17)
Induction of lipopolysaccharide-binding protein gene expression in cultured rat pulmonary artery smooth muscle cells by interleukin 1 beta. (1995) (17)
Identifying patients with time-sensitive injuries: Association of mortality with increasing prehospital time (2019) (17)
Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia. (2010) (17)
Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock–Induced Liver Injury (2019) (17)
Nitric oxide, hepatocytes and inflammation. (1995) (17)
Nitric oxide synthase gene transfer to the vessel wall. (1999) (17)
Interaction between ischemia/reperfusion-induced leukocyte emigration and translocating bacterial enterotoxins on enteric muscle function. (1997) (17)
REDD‐1 aggravates endotoxin‐induced inflammation VIA atypical NF‐κB activation (2018) (17)
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli. (2001) (17)
Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1&agr; in Mouse Hepatocytes (2011) (16)
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans (2017) (16)
Cyclic AMP and Cyclic GMP suppress TNFα-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway (2006) (16)
A Role for Angiotensin II in the Activation of Extracellular Signal-Regulated Kinases in the Liver During Hemorrhagic Shock (2003) (16)
CD14 Contributes to Warm Hepatic Ischemia-Reperfusion Injury in Mice (2013) (16)
Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury. (2019) (16)
TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis (2018) (15)
The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9 (2021) (15)
Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis (2021) (15)
Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain (2021) (15)
Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock (1999) (15)
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase (2004) (15)
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses (2021) (15)
Novel chemokine-like activities of histones in tumor metastasis (2016) (15)
Z-DNA binding protein 1 promotes heatstroke-induced cell death (2022) (15)
Significant Sex-Based Outcome Differences in Severely Injured Chinese Trauma Patients (2014) (15)
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen (2019) (14)
A ROLE OF NEUTROPHILS IN THE DOWN‐REGULATION OF IL‐6 AND CD14 FOLLOWING HEMORRHAGIC SHOCK (1998) (14)
Caspase-11 signaling enhances graft-versus-host disease (2019) (14)
Anti-HMGB 1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma : Attenuated T-Lymphocyte Response and Increased Splenic CD 11 b + Gr-1 + Myeloid-Derived Suppressor Cells Require HMGB 1 (2015) (14)
The role of type 1 interferons in Gram-negative bacteria-induced coagulation. (2020) (14)
Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells (2017) (14)
The importance of empiric abdominal computed tomography after urgent laparotomy for trauma: do they reveal unexpected injuries? (2014) (14)
Pyruvate inhibits clofibrate-induced hepatic peroxisomal proliferation and free radical production in rats. (1995) (14)
Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein* (2016) (14)
Time for trauma immunology (2017) (14)
Toll-Like Receptor Signaling in Liver Diseases (2011) (14)
Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice (2017) (14)
Hepatocyte and Kupffer Cell Interactions (1992) (14)
The Plasma Pharmacokinetics of R-(+)-Lipoic Acid cited in the following articles (listed chronologically); Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic (2009) (14)
A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice (2018) (13)
Radiographic assessment of ground-level falls in elderly patients: Is the "PAN-SCAN" overdoing it? (2013) (13)
Superior Myocardial Preservation with HTK Solution over Celsior in Rat Hearts with Prolonged Cold Ischemia (2010) (13)
Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Integrin β3-Dependent Pathway in Mice (2016) (13)
Regulation of drug-metabolizing enzymes by local and systemic liver injuries (2016) (13)
Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. (2000) (13)
Blunt cerebrovascular injury in elderly fall patients: are we screening enough? (2018) (13)
Expression and Immunoaffinity Purification of Human Inducible Nitric-oxide Synthase (1996) (12)
Two unique aspects of inducible .N = O synthase in liver cells and accessory cells: hepatic damage is minimized by hepatocyte .N = O production and immunoregulation is mediated by macrophage .N = O production. (1991) (12)
cAMP induces CD14 expression in murine macrophages via increased transcription (2000) (12)
Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis (2021) (12)
EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation (2019) (12)
Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p 53 (2004) (12)
Other clinical studyFurther characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes☆ (1995) (12)
Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients (2020) (11)
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway (2020) (11)
Disparities in rural versus urban field triage: Risk and mitigating factors for undertriage (2020) (11)
Toll-like receptor 4 mediates the regenerative effects of bone grafts for calvarial bone repair. (2015) (11)
Hypoxia renders hepatocytes susceptible to cell death by nitric oxide. (2005) (11)
Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes. (2003) (11)
Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock (2019) (11)
ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASE IN TRANSPLANT ARTERIOSCLEROSIS (1999) (11)
NO and hepatocellular cancer (2019) (11)
Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness (2021) (11)
Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo. (2008) (11)
The vasoregulatory role of endothelium derived nitric oxide during pulsatile cardiopulmonary bypass. (1996) (11)
Vasospasm and Platelet Deposition in Human Arteries: Effects of Topical Methylene Blue (1991) (11)
Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model (2017) (11)
Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis. (2020) (10)
Hepatic dysfunction in multiple systems organ failure as a manifestation of altered cell-cell interaction. (1989) (10)
Role of monokines in altering hepatic metabolism in sepsis. (1989) (10)
68 – Biology of Nitric Oxide: Measurement, Modulation, and Models (2001) (10)
Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation (2017) (10)
Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice. (2001) (10)
Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavening (2003) (10)
TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice (2017) (10)
A putative “chemokine switch” that regulates systemic acute inflammation in humans (2021) (10)
TLR4/MyD88-induced non-migratory myeloid cells suppress Th2 effector function in the lung (91.15) (2010) (9)
Targeting CD47: NO limit on therapeutic potential. (2007) (9)
Role of NO and Nitrogen Intermediates in Regulation of Cell Functions (1997) (9)
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis (2022) (9)
Radiographic assessment of splenic injury without contrast: is contrast truly needed? (2012) (9)
Analysis of the Plasma Metabolome after Trauma, Novel Circulating Sphingolipid Signatures, and In-Hospital Outcomes. (2021) (9)
Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes (2021) (9)
Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks (2021) (9)
Nitric Oxide: A True Inflammatory Mediator (2000) (9)
Inclusion of uncomplicated infectious mononucleosis in the spectrum of Epstein-Barr virus infections in transplant recipients. (1988) (8)
Elevations in Circulating sST2 Levels Are Associated With In-hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma. (2019) (8)
DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury (2015) (8)
Toll-like Receptor 4 ( TLR 4 ) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B 1 ( HMGB 1 ) Signaling (2015) (8)
Comprar Schwartz's Principles Of Surgery. Absite And Board Review | F. Brunicardi | 9780071606363 | Mcgraw-Hill Education (2010) (8)
High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice (2017) (8)
Requirements for NF-κb activation in hemorrhagic shock (2002) (8)
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis (2020) (8)
Gut Microbiota and Multiple Organ Dysfunction Syndrome (MODS). (2020) (8)
Hemorrhagic shock induces G-CSF expression in bronchial epithelium. (1997) (8)
Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile. (1998) (8)
Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion (2021) (8)
Early lower extremity fracture fixation and the risk of early pulmonary embolus: filter before fixation? (2011) (8)
TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity. (2019) (8)
The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure. (2017) (8)
Inhibition of L-arginine metabolism by N(G)-monomethyl- L-arginine in vivo promotes hepatic damage in response to lipopolysaccharide (1990) (8)
The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner. (2019) (8)
Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma. (2018) (7)
TNF/TNF receptor 1-mediated apoptosis in hepatocytes. (2011) (7)
Should surgeons clone genes? The strategy behind the cloning of the human inducible nitric oxide synthase gene. (1993) (7)
Selective coinduction of cyclooxygenase-2 and inducible nitric oxide synthase in human intestinal smooth muscle during abdominal surgery (1998) (7)
Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma (2019) (7)
A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis (2021) (7)
Metallothionein and HSP-72 are induced in the liver by hemorrhagic shock and resuscitation but not by shock alone. (1996) (6)
Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. (2015) (6)
Mathematical Simulations of Sepsis and Trauma (2005) (6)
Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial (2022) (6)
Regulation of tissue factor expression in smooth muscle cells with nitric oxide. (2003) (6)
Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins. (2013) (6)
BNIP3 Suppresses PINK1 Proteolytic Cleavage to Promote Mitophagy (2016) (6)
The vasoregulatory role of endothelium derived nitric oxide during pulsatile cardiopulmonary bypass (1996) (6)
Characterizing injury severity in nonaccidental trauma: Does Injury Severity Score miss the mark? (2018) (6)
6 – A Role for Nitric Oxide in Liver Inflammation and Infection (1996) (6)
Non-canonical Wnt signaling contributes to ventilator-induced lung injury through upregulation of WISP1 expression (2019) (6)
Identification of a Novel Pathway of Transforming Growth Factor-β1 Regulation by Extracellular NAD+ in Mouse Macrophages (2012) (6)
NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock (2017) (6)
Presidential address: Routine complexity (2001) (6)
The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support. (2010) (6)
The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies (2010) (6)
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway (2021) (5)
The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness (2022) (5)
Nitric oxide-induced p 53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p 53 ( tumor suppressor gene / mutagenesis / carcinogenesis ) (2005) (5)
Immune Activation in the Liver by Nucleic Acids (2016) (5)
Molecular analysis of transplant rejection: marching onward (2013) (5)
MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes (2019) (5)
Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose. (2019) (5)
Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage. (2020) (5)
Oral Intake of Hydrogen-rich Water Inhibits Intimal Hyperplasia in Arterialized Vein Grafts in Rats (2012) (5)
An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients. (2020) (5)
Stable expression of human inducible nitric oxide synthase in V79 Chinese hamster cells. (1996) (5)
Nitric oxide production regulates alloactivation in rat splenocyte mixed lymphocyte cultures. (1991) (5)
Tlr2 on Bone Marrow and Non-Bone Marrow Derived Cells Regulates Inflammation and Organ Injury in Cooperation with Tlr4 During Resuscitated Hemorrhagic Shock (2016) (5)
High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI (2022) (5)
The use of multiplexing to identify cytokine and chemokine networks in the immune-inflammatory response to trauma. (2021) (5)
Adenoviral-mediated gene delivery to liver isografts: improved model of ex vivo gene transfer. (1999) (4)
Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1 (2007) (4)
Requirements for NF-kappaB activation in hemorrhagic shock. (2002) (4)
Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury (2020) (4)
Multidisciplinary acute care research organization (MACRO): If you build it, they will come (2013) (4)
Sponge allograft effector cells exert suppressor function via an L-arginine-dependent mechanism. (1991) (4)
Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding (2020) (4)
GRANULOCYTE COLONY‐STIMULATING FACTOR (G‐CSF) PRODUCTION AND NEUTROPHIL ACTIVATION IN HEMORRHAGIC SHOCK: 42 (1996) (4)
Protective/reparative cytokines are suppressed at high injury severity in human trauma (2021) (4)
Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway. (2006) (4)
HIV Protease Inhibitors in Pulmonary Hypertension: Rationale and Design of a Pilot Trial in Idiopathic Pulmonary Arterial Hypertension (2015) (4)
Nitric Oxide as a Modulator of Sepsis: Therapeutic Possibilities (2000) (4)
Enhanced Calvarial Bone Healing in CD11c-TLR4−/− and MyD88−/− Mice (2017) (4)
T-cell mitogenic responses in fully xenogeneic chimeras (WF rat----B10 mouse) are restored by blocking the L-arginine-dependent nitric oxide pathway. (1992) (3)
Defining geographic emergency medical services coverage in trauma systems. (2019) (3)
Biochemistry and Synthesis of NO in Sepsis (1995) (3)
Trauma Center Maturation (1999) (3)
TBK1/IKKε Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation. (2020) (3)
“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress (2017) (3)
Schwartz's Principles of Surgery Self-Assessment and Board Review (2006) (3)
MD2 and CD14 mediate toll-like receptor 4 (TLR4) activation by high mobility group box 1 (HMGB1) (2007) (3)
Cellular Protective Mechanisms Of Inducible Nitric Oxide Synthase. (2015) (3)
Hypoxia Activates Toll-like Receptor 4 Signaling in Primary Mouse Hepatocytes Through the Receptor Clustering within Lipid Rafts (2011) (3)
G‐CSF and IL‐6 are Produced in the Lung in Hemorrhagic Shock where they Activate STAT Proteins and Mediate Acute Lung Injury: 219 (1997) (3)
Inducible Nitric Oxide Synthase: Its Role in Inflammation, Sepsis, and Shock1 (1995) (3)
Inhalation of Hydrogen Reduced Hyperoxic Lung Injury in Rat Through Heme Oxygenase-1 Induction (2012) (3)
Mechanical Ventilation With Moderate Tidal Volume Exacerbates Extrapulmonary Sepsis-Induced Lung Injury via IL33-WISP1 Signaling Pathway. (2020) (3)
The Role of Nitric Oxide in the Initiation of Inflammation in Shock (2002) (3)
Understanding the role of S-nitrosylation/nitrosative stress in inflammation and the role of cellular denitrosylases in inflammation modulation: Implications in health and diseases. (2021) (3)
Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective (2020) (3)
Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling (2022) (3)
HIV protease inhibitors saquinavir and nelfinavir are potent inhibitors of cathepsin L activity: A potential treatment for COVID-19 patients (2020) (3)
Analysis of Glutathione mediated S-(de)nitrosylation in complex biological matrices by immuno-spin trapping and identification of two novel substrates. (2021) (3)
A novel inhibitory peptide of Toll-like receptor signaling limits LPS-induced production of inflammatory mediators and enhances survival in mice (89.12) (2007) (3)
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis (2022) (3)
Cellular non-heme iron modulates apoptosis and caspase 3 activity (2007) (3)
Mathematical models predict the course of the inflammatory response in rats subjected to trauma-hemorrhagic shock and to anti–tumor necrosis factor α therapy in endotoxemia (2005) (2)
Making the call in the field: Validating emergency medical services identification of anatomic trauma triage criteria (2021) (2)
There’s NO Business Like p53 Business: Nitric Oxide Regulates Phosphorylation of p53 in Chronic Inflammatory Disease (2003) (2)
Early prediction of length of intensive care unit stay from inflammatory mediators in trauma patients (2011) (2)
Nitric oxide in trauma and sepsis (2001) (2)
Nitric Oxide in Sepsis and Hemorrhagic Shock: Beneficial or Detrimental? (2017) (2)
Abdominal surgery results in early stat protein activation within the rat intestinal muscularis (1998) (2)
Routine complexity. (2001) (2)
Intraoperative upregulation of muscularis IL-6, Stat3 activation and an association between neutrophil infiltration and muscle dysfunction in human (1998) (2)
GENE THERAPY AS A POTENTIAL TREATMENT FOR BPH; INJECTION OF MYOBLAST-ADENOVIRUS TRANSFECTED WITH HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) INTO THE PROXIMAL URETHRA (1999) (2)
Depression and health care utilization and costs in patients diagnosed with cancer. (2019) (2)
Cloning and expression of human inducible nitric oxide synthase. (1998) (2)
Interactive multi-site video teleconferencing as a means to increase surgical resident and staff participation at core teaching conferences (2007) (2)
TLR 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation (2014) (2)
Making progress in an enlightened era: opportunities and obstacles. (2007) (2)
RECOMMENDED LITERATURE 1. Schwartz's Principles of Surgery, 2009 (2010) (2)
Genetic Deletion of TLR4 on Platelets Attenuates Experimental Pulmonary Hypertension (2014) (2)
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation (2020) (2)
In vitro immunosuppressive effects of murine hepatocyte cytosol. (1989) (2)
Tumor Necrosis Factor Alpha Inhibits Hepatocyte Mitochondrial Respiration and Induces Release of Cytoplasmic Enzymes (1993) (2)
IN SILICO AND IN VIVO STUDIES MODELING THE AGED ACUTE INFLAMMATORY RESPONSE (2006) (2)
Corrigendum: TLR4/MyD88-induced CD11b+Gr-1intF4/80+non-migratory myeloid cells suppress Th2 effector function in the lung (2011) (2)
The therapeutic use of L-arginine to increase nitric oxide production. (1992) (2)
The Whole is Greater Than the Sum of its Parts: GCS Versus GCS-Motor for Triage in Geriatric Trauma. (2021) (2)
Correction: TLR4 Signaling Augments Monocyte Chemotaxis by Regulating G Protein–Coupled Receptor Kinase 2 Translocation (2013) (2)
Nitric Oxide, Oxygen Radicals (2004) (2)
Oxidase Activation in Neutrophils: Role of Hemorrhagic Shock Induces NAD(P)H (2013) (2)
Induction of reperfusion-independent early events in the inflammatory cascade of hemorrhagic shock (2000) (2)
Inducible nitric oxide synthase attenuates acute cardiac rejection (2000) (1)
132: Up-regulation of the pro-death protein FADD is dependent on ROS production in TNF-Α mediated apoptosis in hepatocytes (2007) (1)
Single-Cell Transcriptomics Reveals Compartment-Specific Differences in Immune Responses and Contributions for Complement Factor 3 in Hemorrhagic Shock Plus Tissue Trauma (2021) (1)
PS228. LPS Induces Angiogenic Behavior in Human Umbilical Vein Endothelial Cells In Vitro through Purinergic Signalling (2011) (1)
Activation of C-JUN N-terminal kinase (JNK) in mouse liver during hemorrhagic shock (2000) (1)
TLR 4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 ( TLR 2 ) in Ischemic Skeletal Muscle and Endothelial Cells (2015) (1)
Carbon monoxide acts via inhibition of cytochrome oxidase and generation of mitochondrial reactive oxygen species (2006) (1)
Hydrogen inhalation ameliorates ventilator-induced lung injury Short Running Head: Hydrogen Mitigates Lung Injury (2010) (1)
Arginase blockade as a strategy to mitigate liver ischemia-reperfusion (I/R) injury (2006) (1)
Intraperitoneal injection of class A TLR9 agonist enhances anti–PD-1 immunotherapy in colorectal peritoneal metastases (2022) (1)
The Role of Nitric Oxide in Hemorrhagic Shock and Trauma (1995) (1)
PREDICTING THE ACUTE INFLAMMATORY RESPONSE IN COMBINED TRAUMA‐HEMORRHAGE AND ENDOTOXEMIA USING MATHEMATICAL SIMULATIONS: 146 (2004) (1)
250: INDIVIDUAL-SPECIFIC PRINCIPAL COMPONENT ANALYSIS PREDICTS EARLY ORGAN DYSFUNCTION IN TRAUMA PATIENTS (2013) (1)
Increased Risk of Adrenal Insufficiency Following Etomidate Exposure in Critically Injured Patients—Invited Critique (2008) (1)
11. Cytoprotective actions of nitric oxide in hepatic inflammation (2017) (1)
Acknowledgment to Reviewers (2019) (1)
Preparation of volumetric skeletal muscle whole organ acellular matrix to regenerate contractile, vascularized, innervated muscle in rodent and canine model (2013) (1)
Efficacy of a stepped collaborative care intervention for comorbid cancer and depression: Health care utilization and costs. (2019) (1)
Molecular Regulation of the Human Inducible Nitric Oxide Synthase Gene: 677 (1997) (1)
Gene therapy. (1996) (1)
Nitric oxide synthases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Hyporeactivity to Phenylephrine in Isolated Perfused Livers from Endotoxin-treated Rats: Reversal by Nitric Oxide Blockage (1994) (1)
Carbon monoxide treats experimental pulmonary arterial hypertension via nitric oxide synthase (2005) (1)
PLOS Medicine 2017 Reviewer and Editorial Board Thank You (2018) (1)
Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill (2022) (1)
Impaired interferon-γ signaling promotes the development of silicosis (2022) (1)
Endothelial Nitric Oxide Synthase (eNOS) is not Required for Basic Fibroblast Growth Factor (bFGF) Induced Angiogenesis in vivo (1999) (1)
Robust and accurate estimation of cellular fraction from tissue omics data via ensemble deconvolution (2022) (1)
Hemorrhagic Shock: From Physiology to Molecular Biology (1997) (1)
Failing to Rescue Our Elders: Increased Mortality and Transfer Status in Geriatric Trauma (2015) (1)
ATTENUATION OF CARDIAC ALLOGRAFT VASCULOPATHY BY ADENOVIRAL GENE TRANSFER OF INDUCIBLE NITRIC OXIDE SYNTHASE (1999) (1)
THE ROLE OF REPERFUSION IN IL‐6 AND ICAM‐1 EXPRESSION IN HEMORRHAGIC SHOCK.: 237 (1996) (1)
Lack of Beneﬁt on Brain Edema, Blood–Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury (2018) (1)
The Involvement of Apoptosis in Inflammatory Liver Failure (1998) (1)
Targeting Nitric Oxide: Say NO to Metastasis. (2022) (1)
O22. Distinct roles of different nitric oxide synthase isoforms in regulating hematopoietic stem cell function in vivo (2006) (1)
Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness. (2020) (1)
Regulation and Function of Nitric Oxide in the Liver (1999) (1)
Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression (2022) (1)
QS383. Calcium/Calmodulin-Dependent Protein Kinase IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 During LPS Stimulation of Macrophages (2008) (1)
Fatty acid binding protein-4 ( FABP 4 ) is a hypoxia inducible gene that sensitizes mice to liver ischemia / reperfusion injury (2016) (1)
Increased expression of vascular endothelial growth factor in steroid treated murine wounds (2000) (1)
Nitric oxide inhibits specific enzymes in the Krebs cycle and the respiratory chain of rat hepatocyte mitochondria (1990) (1)
Stimulation of Macrophages HMGB 1 during Lipopolysaccharide Nucleocytoplasmic Shuttling and Release of Kinase ( CaMK ) IV Mediates Calcium / Calmodulin-Dependent Protein (2008) (1)
Geospatial assessment of helicopter emergency medical service overtriage (2021) (1)
Caspase-11-mediated HMGB1 release from the liver drives immune cell pyroptosis in sepsis. (2017) (1)
Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma (2020) (1)
INHIBITION OF NITRIC OXIDE SYNTHASE DURING HEMORRHAGIC SHOCK INCREASES HEPATIC INJURY.: 108 (1995) (1)
An adaptive, negative feedback circuit in a biohybrid device reprograms dynamic networks of systemic inflammation in vivo (2023) (1)
The Cytokine Response to Hemorrhagic Shock (1997) (1)
Caspase-1 is protective during trauma and hemorrhagic shock in mice (2009) (1)
Abstract 91: INFLUENCED CALVARIAL HEALING AFTER BONE COMPONENTS IMPLANTATION IN THE ABSENCE OF TLR2 AND TLR4 (2013) (1)
Acknowledgment of Guest Editors, 2019 (2019) (1)
Hepatocyte‐specific high‐mobility group box 1 (HC‐HMGB1) protects against liver fat accumulation and cellular stress during high fat diet feeding (2018) (1)
P183. Inducible nitric oxide synthase localization to peroxisomes in hepatocytes is modulated by PEX5 and PEX7 (2006) (1)
A ROLE FOR ANGIOTENSIN II IN THE EARLY ACTIVATION OF MAP KINASE IN HEMORRHAGIC SHOCK: 42 (2001) (1)
Patient-Specific Precision Injury Signatures to Optimize Orthopaedic Interventions in Multiply Injured Patients (PRECISE STUDY). (2022) (0)
The protective role of nitric oxide in hepatocytes during responses to inflammatory mediators and induction of apoptosis (2000) (0)
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EFFECTS OF RINGER'S ETHYL PYRUVATE SOLUTION ON JNK PHOSPHORYLATION IN HEMORRHAGIC SHOCK AND IN HYPOXIC HEPATOCYTES.: 168 (2003) (0)
Regulation of p27kip1 and Ikaros in Alginate‐induced Hepatic Fibrosis (2011) (0)
Toll-like receptor 9 inhibition improves immune response in late posttraumatic mice (2010) (0)
Expression ofhumaninducible nitric oxidesynthase ina tetrahydrobiopterin (H4B)-deficient cellline: H4Bpromotes assembly ofenzymesubunits intoanactive dimer (1995) (0)
Reactive oxygen species, nitric oxide and apoptosis (2000) (0)
of hepatic injury after trauma-hemorrhagic shock Insights into the role of interleukin-6 in the induction (2015) (0)
QS214. Complement Component C3 is Critical to the End Organ Injury and Inflammatory Response Seen in Trauma (2009) (0)
THE RAPID UPREGULATION OF EARLY GROWTH RESPONSE‐1 (EGR‐1) IN HEMORRHAGIC SHOCK REGULATES INFLAMMATION IN THE LIVER: 163 (2004) (0)
Mice Subjected to Severe Peripheral Trauma Are Resistant to Pseudomonas Infection at 48 Hours Despite Suppression in Lymphocyte Responses (2012) (0)
The role of serine/threonine & tyrosine phosphatases in mediating inhibition of vascular smooth muscle cell proliferation (2000) (0)
Obesity and insulin resistance increases sensitivity to sepsis-induced hepatotoxicity (2004) (0)
Integrated oral session 1: Wed 2/7 1:00 pmTrauma/critical care I: Injury and immunity66: Systemic inflammation and end organ injury after peripheral tissue injury requires functional TLR4 on bone marrow-derived cells (2007) (0)
Abstract 61: CALVARIAL BONE HEALING IN THE ABSENCE OF TLR2 AND TLR4 (2013) (0)
32: Low dose carbon monoxide protects rat lung grafts from ischemia-reperfusion (2006) (0)
Toll-like receptor 4 (TLR4) signaling by both graft and recipient cells is necessary for maximal inflammation after cardiac cold ischemia-reperfusion (2007) (0)
IFN Production Responding to Viral and Limits RIG-I RNA Detection and Suppresses Adenosine Deaminase Acting on RNA 1 (2014) (0)
Interleukin-6 Neutralizing Antibody Treatment Restores Th1/Th2 Balance in Mice With Pseudo-Fracture and Hemorrhage (2013) (0)
Hearts transfected with inducible nitric oxide synthase have accelerated restoration of cardiac function following ischemia/reperfusion associated with cardiac transplantation (2003) (0)
Computational simulation of individual inflammation and outcomes in trauma patients (2008) (0)
Surgical Infection Society Presidential Address Perspectives in Surgical Infections : What Does the Future Hold ? (2010) (0)
Regulation of hepatic drug metabolism by liver I / R 2 . 1 (2016) (0)
428: Hydrogen Inhalation Prevents Ischemia/Reperfusion Injury of Rat Cardiac Grafts (2008) (0)
Induction and activation of macrophage transforming growth factor-β1 by extracellular nicotinamide adenine dinucleotide (NAD+) and its metabolite, cyclic ADP ribose: In vitro and in silico studies (2012) (0)
PGI2 REGULATES NITRIC OXIDE SYNTHESIS IN RAT PULMONARY ARTERY VASCULAR SMOOTH MUSCLE: 181 (1996) (0)
Session IV: Arginine and Pathophysiology II—Discussion Summary (2004) (0)
Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding (2020) (0)
Hepatocyte and Kupffer Cell Interactions (1992) (2017) (0)
Mice deficient in eNOS have normal blood pressure response to resuscitation but increased early mortality following hemorrhagic shock (2000) (0)
187. Increased End Organ Injury and Inflammation in Obese Mouse Model of Hemorrhagic Shock (2008) (0)
IN VIVO EXPOSURE TO LPS DESENSITIZES HEPATOCYTES TO SUBSEQUENT STIMULATION WITH BACTERIAL PRODUCTS: ROLE OF TLR4: 170 (2001) (0)
80. Complement Factor B Upregulation by Macrophages Upon Toll-Like Receptor 3 (TLR3) and TLR4 Ligand Stimulation Is NF-kB Dependent (2008) (0)
Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis (2018) (0)
Delayed, intermittent inhaled CO improves perfusion and limb recovery in a mouse hindlimb ischemia model (2011) (0)
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The Novel Mechanism for WISP1 Synergizes with TLR Agonist in Macrophage Activation (2014) (0)
P3-329 Carbon monoxide prevents structural deterioration in the hippocampus in hypertensive rats: a novel mechanism of galantamine against vascular related dementia (2004) (0)
Double-Stranded RNA Dependent Protein Kinase (PKR) Deficiency Protects the Liver Against Ischemia/reperfusion Injury (2021) (0)
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The Identification of a Novel TLR4 Inhibitor With Potent Anti-inflammatory Effects in Vivo Using a Combined in Silico and in Vivo Approach (2012) (0)
Exercise Protects Against Organ Damage from Trauma/Hemorrhagic Shock via Modification of Immune Cell Progenitors (2022) (0)
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Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER- Breast Tumors that Lead to Poor Outcome (2023) (0)
The role of high mobility group protein B1 (HMGB1) in hepatic ischemia and reperfusion (I/R) injury (2013) (0)
Altered connexin expression in nitric oxide synthase knockout mice: a potential mechanism for delayed wound healing (2000) (0)
Multi-Omic Admission-Based Biomarkers Predict 30-day Survival and Persistent Critical Illness in Trauma Patients after Injury (2022) (0)
Author Correction: Caspase-11 signaling enhances graft-versus-host disease (2020) (0)
Nonparenchymal Cells Involves Functional TLR4 Signaling in Hepatic Ischemia/Reperfusion Injury (2005) (0)
Nitric oxide: at the heart of the matter (2001) (0)
The role of TLR4 and free fatty acids on hepatocellular injury: an obese mouse model of hemorrhagic shock (2010) (0)
iNOS In Post-Traumatic Immunosuppression: A TLR 4 Dependent Process (2011) (0)
Short-Term Administration of HIV Protease Inhibitor Saquinavir Improves Skull Bone Healing with Enhanced Osteoclastogenesis (2022) (0)
THE RESPONSE OF CD14 KNOCKOUT MICE TO HEMORRHAGIC SHOCK: 43 (1996) (0)
Mast Cells Play a Critical Role in the Systemic Inflammatory Response and End Organ Injury to Trauma (2011) (0)
INHALED HYDROGEN GAS THERAPY FOR DONORS MITIGATES VENTILATOR-INDUCED LUNG GRAFT INJURY: 1441 (2010) (0)
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Decision letter: Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia (2021) (0)
The HMGB1-MD-2 axis as a novel therapeutic target in inflammatory diseases (CCR5P.210) (2015) (0)
Direct Trauma Center Access by Helicopter Emergency Medical Services is Associated with Improved Survival after Severe Injury. (2023) (0)
A16. NO/cGMP regulation of cell death (2007) (0)
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway (2021) (0)
From mice to rats: interspecies prediction of the systemic inflammatory response using mathematical simulations (2006) (0)
CYTOPROTECTIVE ACTIONS OF NITRIC OXIDE IN THE LIVER: NO INHIBITS HEPATOCYTE APOPTOSIS: 453 (1997) (0)
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Actinomycin D Induces Hepatocyte Cell Death and Upregulation of FADD/MORT1 (2001) (0)
TLR4 MEDIATES HEMORRHAGIC SHOCK-INDUCED NADPH OXIDASE ACTIVATION IN NEUTROPHIL (2006) (0)
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Bacterial Endotoxin Activates Coagulation Cascades Through GSDMD-Dependent Phosphatidylserine Exposure (2019) (0)
A computational analysis of dynamic, multiorgan inflammation induced by endotoxin in mice (2017) (0)
Circulating Monocytes Show Early and Persistent Changes by Single Cell Transcriptomic Analysis in Response to Major Elective Surgery (2021) (0)
The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa. (2004) (0)
The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9 (2021) (0)
Biliverdin protects against acute Tnf-α-induced fulminant hepatitis in vivo and hepatocyte cell death in vitro (2004) (0)
Intestinal Heat Shock Protein 70 (HSP70) Over Expression Attenuates Local and Remote Inflammation and Organ Injury Following Hemorrhagic Shock and Trauma (2012) (0)
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Novel Role of Cathepsin V in TLR4 Mediated Signaling (2014) (0)
Toll-like receptor 9 plays a significant role in end-organ injury and the inflammatory response to trauma (2008) (0)
Hepatocyte Interferon Regulatory Factor-1 Mediates Acetylation of High Mobility Group Box-1 to Promote Release during Ischemic Liver Injury (2010) (0)
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Author index and subject index (1976) (0)
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Initial Non-Contrast Abdominal CT Imaging Post-Injury: Who should have Contrast Omitted and at What Expense (2013) (0)
P160 – Nitrosation of cysteines HMGB1 increases cell migration (2014) (0)
NLRs in mouse hepatocytes respond to specific ligands to activate NF{kappa}B (2009) (0)
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IL3 Gene therapy to limit the occlusive complications of cardiovascular surgery (2001) (0)
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Autophagic flux alters hepatic iNOS protein accumulation, functional form, and localization (151.8) (2014) (0)
High Dimensional Proteomics Identifies Organ Injury Patterns Associated with Outcomes in Human Trauma. (2023) (0)
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Advances in Brief Cysteine 230 Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activity 1 (2000) (0)
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Transferable Kupffer cell products induce an L-arginine-dependent cytostatic mechanism in hepatocytes (1990) (0)
To pimp or not to pimp: Increased interactive format for morbidity and mortality conference improves educational value and enhances resident confidence (2006) (0)
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Temporal Transcriptomic Response of Murine Liver to Trauma and Hemorrhagic Shock: A Dual Platform Microarray Analysis (2010) (0)
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Oral 1821-1 – Hepatocyte-TNFR1 shedding limits excessive inflammation during sepsis via iNOS-cGMP-TACE-dependent signaling (2014) (0)
Mini-oral session: Fri 2/15 4:00 pmTrauma/critical care VII: Sepsis and signaling IQS387. Calcium/Calmodulin-Dependent Protein Kinases (CaMK) Inhibition Ameliorates Hepatic Injury and Systemic Inflammation After Hemorrhagic Shock (2008) (0)
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Comparison of the specificity of three endothelial‐specific promoters: Flt1, ICAM2 and vWF (2006) (0)
Inducible NOS Contributes to Late Post-Traumatic Immune Dysfunction (2010) (0)
Accelerated Bone Healing in the Absence of TLR4 (2012) (0)
An AGS associated mutation causes cellular RNA editing deficiency in mouse brain which lead to IFN pathway activation, mimicking the interferonopathy of patient brains (2021) (0)
TLR4 Deletion Ameliorates MSC –mediated Protection Effects in Liver Ischemia/Reperfusion Model (2014) (0)
Toll-Like Receptor 4 On Hepatocytes Is Necessary For Maximal Hepatic Ischemia-Reperfusion Injury (2011) (0)
Enzyme) b Macrophages by Inhibiting Caspase-1 (IL-1 -Inducing Factor (IL-18) Release from g and IFN- b Nitric Oxide Prevents IL-1 (1998) (0)
High-mobility group box 1 (HMGB1) release in response to hypoxia is calcium dependent (2006) (0)
THE SYNERGISTIC EFFECT OF CARBON MONOXIDE AND BILIVERDIN FOR KIDNEY AND CARDIAC ISCHEMIA/REPERFUSION INJURY (2004) (0)
Aged Mice are More Susceptible to Candida Infection Than Young Mice in A Multi-compartment Trauma Model (2013) (0)
iNOS REGULATES HEPATIC PERFUSION AFTER SHOCK AND RESUSCITATION (1999) (0)
A novel role for iNOS in formation of cGMP-dependent protein complex regulating TNF-receptor shedding and hepatocellular protection during endotoxemia (2012) (0)
GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis (2022) (0)
QS72. Transforming Surgical Residents Into Academic Surgeons Through Mentored Clinical Research Rotations (2009) (0)
MDSC-derived and TIL-endogenous NO plays a crucial role in the induction and stability of Th17 cells in human ovarian cancer (TUM4P.915) (2014) (0)
through Impaired Pyrin Induction Inflammasome Activation in the Lung Hemorrhagic Shock Augments Nlrp3 (2013) (0)
Cancer immunotherapy: TLRs, NLRs, and RLRs (2007) (0)
In response to Schibilsky et al (2010) (0)
Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway (2019) (0)
Inhibition with TLR4 Antagonist Eritoran Tetrasodium (E5564) Attenuates Hepatic Ischemia/Reperfusion (I/R) Injury (2014) (0)
Transcriptomic response of murine liver to severe injury and hemorrhagic shock: A dual platform microarray analysis (2009) (0)
TLR9 deficiency in parenchymal or immune cells is associated with reduced tissue damage in a trauma model (2009) (0)
Pan-Caspase Inhibitor Prevents Anti-CD3 Mediated T-Lymphocyte Proliferation (2001) (0)
Liver Injury in Kupffer Cells during Sterile Inflammatory Histones Activate the NLRP3 Inflammasome (2013) (0)
Toll-like receptor 4 mediated injury after hepatic ischemia-reperfusion involves reactive oxygen species (2006) (0)
The role of nitric oxide in cardiomyogenesis using embryonic stem cells (2004) (0)
Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain (2021) (0)
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness (2022) (0)
CO Promotes Limb Recovery in Mouse Hindlimb Ischemia Independent of HO (2012) (0)
Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients (2022) (0)
NICOTINIC ACETYLCHOLINE RECEPTOR a7 AGONIST INHIBITS INDUCED NITRIC OXIDE SYNTHASE EXPRESSION IN HEPATOCYTES AND RAW CELLS.: 223 (2004) (0)
QS385. Temporal Transcriptomic Response of Murine Liver to Severe Injury and Hemorrhagic Shock (2009) (0)
Abstract 983: Reciprocal Regulation of Caveolin-1 Expression and Bone Morphogenetic Protein Signaling in Mouse Aortic Smooth Muscle Cells (2006) (0)
Adenosine Bolus Injection Prior to Cardioplegia Enhances Preservation of Heart Grafts in Rats (2012) (0)
TIME COURSE OF INDUCIBLE NITRIC OXIDE SYNTHASE AND CYCLOOXYGENASE-2 UPREGULATION DURING HEMORRHAGIC SHOCK (1999) (0)
Comparative evaluation of antiperistaltic exit conduits, autologous smooth muscle wraps, and nipple valves for ileostomy continence. (1986) (0)
oxide synthesis New insights into the regulation of inducible nitric (2016) (0)
OS 02-05 MYD88 ON MACROPHAGE TRIGGERS CATHEPSIN L ACTIVATION DRIVEN VASCULAR INTIMAL HYPERPLASIA. (2016) (0)
Towards an improved extracorporeal liver support device: Nitric oxide (NO) inhibits apoptotic liver cell death in a four compartment bioreactor culture model (2006) (0)
MDA-5 mediated RNA sensing signaling responds to the cellular RNAs escaped from RNA surveillance causing apoptotic cell death (2020) (0)
SEPSIS AND ENDOTOXEMIA ??? NEW THERAPEUTIC APPROACHES (1995) (0)
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen (2019) (0)
Abstract 232: The P2Y2 Nucleotide Receptor Mediates Blood Flow Recovery Following Hindlimb Ischemia in Mice (2012) (0)
AIM2 inflammasome is protective in regulating adaptive responses to oxidative stress in the liver (INM6P.410) (2014) (0)
Carbon monoxide paradoxically protects against hypoxia (2003) (0)
Immuno‐Spin Trapping Method for the Analysis of S‐Nitrosylated Proteins (2021) (0)
Inhaled carbon monoxide abrogates pulmonary hypertension (2003) (0)
95. Mammalian DNA is an Endogenous Danger Signal That Stimulates Local Complement Synthesis and Release (2009) (0)
TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis (2018) (0)
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation (2020) (0)
Mammalian DNA Danger Signaling Induced Complement Factor B Requires HMGB1 (2011) (0)
HEPATIC INJURY AND SYSTEMIC INFLAMMATION AFTER TRAUMA REQUIRES TLR4 AND IS MEDIATED BY HMGB1 (2006) (0)
Roles for Induced Nitric Oxide in Endotoxic and Hemorrhagic Shock (1999) (0)
61; INCREASED EXPRESSION OF LBP, and CD14 IN THE LUNG FOLLOWING HEMORRHAGIC SHOCK (1994) (0)
Featured Articles for CME Credit January 2016. (2016) (0)
Central role of danger signals in sepsis, trauma, and hemorrhage: insights from mathematical simulations (2005) (0)
A Systemic Storm in Critically Injured Humans Revealed by Longitudinal Multi-Omics (2021) (0)
CEREBROSPINAL FLUID NITRITE/NITRATE AND CEREBRAL BLOOD FLOW AFTER HUMAN HEAD INJURY. (1995) (0)
A temporal analysis of the hepatic transcriptomic response to bone fracture and hemorrhagic shock in mice (2007) (0)
current as-Galactosylceramide α by in NKT Cell-Mediated Liver Injury Induced A Critical Role for IFN Regulatory Factor 1 (2010) (0)
Intestinal Barrier Translocation of Bacteria Across the Enterocyte TLR4 Mediates Phagocytosis and (2013) (0)
DC-specific HMGB1 KO mice clear vaccinia viral infection more effectively (VIR5P.1018) (2014) (0)
Up-regulation of the pro-death protein fadd requires caspase-8 activation and bid cleavage in hepatocytes (2006) (0)
Biomarkers to Distinguish Sepsis From Sterile Inflammation. (2020) (0)
Hydrogen sulphide synthesis (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
Traumatic serum factors accentuate hepatic injury from ischemia/reperfusion (2006) (0)
Degree of fracture-associated soft-tissue injury modifies systemic inflammation and remote organ dysfunction after bilateral femur fracture (2007) (0)
TLR4-competent hematopoietic cells are required for systemic inflammation and hepatic injury after trauma/hemorrhage (2006) (0)
A New Hydrogen Administration Method for Organ and Cardiac Graft Preservation (2014) (0)
ModelsofLowerExtremityDamageinMice:TimeCourseofOrganDamage and Immune Response (2011) (0)
Heme oxygenase–1(HO-1)/carbon monoxide(CO) inhibit apoptotic signaling via a NFKB dependent pathway (2006) (0)
NLRs in mouse hepatocytes respond to specific ligands to activate NFκB (135.78) (2009) (0)
222. Systemic Inflammatory Response in a Novel Pseudo-Fracture Murine Model (2009) (0)
Session 4 : Regulation of Immune Response by Nitric Oxide Moderator : Dr . Khosrow Kash fi INVITED SPEAKERS Cellular Protective Mechanisms Of Inducible Nitric Oxide Synthase (2015) (0)
TLR4 on Dendritic Cells Regulates Organ Damage After Trauma (2014) (0)
Reply: To PMID 24798499. (2015) (0)
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis (2019) (0)
High mobility group box-1 (HMGB1) preconditioning protects against hepatic ischemia reperfusion injury (2006) (0)
Reply (2015) (0)
PLASMINOGEN ACTIVATOR INHIBITOR‐1 (PAI‐1) CONTRIBUTES TO HEPATIC INJURY DURING HEMORRHAGIC SHOCK: 133 (2004) (0)
The contribution of toll like receptors 2,4 & 9 to delayed immune dysfunction following injury (2012) (0)
LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS (2022) (0)
Genome-Wide Analysis Suggests a Differential Interaction between Genetic Polymorphism and Injury Severity in Driving Outcomes Post-Injury (2022) (0)
Small intestine transplantation in rats (2013) (0)
Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties (2023) (0)
SOCS1 CONTRIBUTES TO LPS DESENSITIZATION IN MOUSE HEPATOCYTES.: 108 (2004) (0)
Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis (2021) (0)
123: High-mobility group box 1 (HMGB1) release in response to hypoxia involves TLR4-dependent production of reactive oxygen species (2007) (0)
Hepatic Egr-1 Signalling after Oxidative Stress Is TLR4 Dependent (2010) (0)
Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury (2018) (0)
TNF signaling induces the tumor necrosis factor receptor‐1 (TNFR1) complex with the members of death‐inducing signaling complex (DISC) to localize the nucleus in hepatocytes (2008) (0)
P189. Interactions of poly-S-nitroso-NOS with thioredoxin and caspase 3 (2006) (0)
127: Calcium supplementation induces cytokine production through calcium/calmodulin-dependent protein kinases (CaMK) in an in vivo cecal ligation and puncture (CLP) model of sepsis (2007) (0)
The role of HMGB1's critical cysteines are explored in human monocytes (CAM1P.151) (2015) (0)
119: Carbon monoxide activates NF-Î°B to protect against cell death of hepatocytes via ROS generation and Akt pathways (2007) (0)
TLR4‐signaling is required for NOD2 but not NOD1 activation in hepatocytes (2008) (0)
32: Nitrite Protects Rat Lung Grafts from Ischemia/Reperfusion Injury Via Xanthine Oxidoreductase (XOR) (2008) (0)
114 MOLECULAR CHARACTERIZATION OF THE HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE GENE PROMOTER (1995) (0)
THE NO SCAVENGER, NOX, PROTECTS AGAINST PULMONARY INFLAMMATION FOLLOWING HEMORRHAGIC SHOCK.: 65 (1998) (0)
This information is current as Acute Lung Inflammation Macrophage: Role in Posthemorrhagic Shock Anti-Inflammatory Mechanisms in Alveolar Neutrophils Counteract Autophagy-Mediated (2017) (0)
Systemic hypovolemic hemorrhagic shock initiates a molecular and cellular inflammatory response in the mouse intestine that is accompanied by gastrointestinal motility dysfunction (2000) (0)
What is the role of bone-matrix and bone-marrow released in soft-tissue injury following fractures in the induction of systemic inflammation and remote organ damage? (2007) (0)
Non-vascular myocyte TLR4 regulates intestinal and systemic inflammation and prevents late ileus in murine endotoxemia (2012) (0)
Pre-hemorrhage protects the colon against subsequent sepsis (2005) (0)
EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation (2019) (0)
Dynamic Hypergraphs: A novel analysis pipeline for defining spatiotemporal inflammation networks (2023) (0)
63: Post-traumatic bacterial translocation (BT) is toll-like receptor 4 (TLR4) dependent but does not drive the inflammatory response (2007) (0)
RESUSCITATED HEMORRHAGIC SHOCK LEADS TO INDUCTION OF PULMONARY METALLOTHIONEIN mRNA, BUT NOT HSP70 INDUCTION.: 44 (1996) (0)
Hemorrhagic shock primes for IL-1{beta} processing: role of upregulated TLR2 (2010) (0)
Invited commentary (2005) (0)
Functional toll-like receptor 4 signaling in liver non-parenchymal cells is required for hepatic ischemia/reperfusion (I/R) injury (2005) (0)
Symposium: The Merinoff World Congress 2013: HMGB1 (2014) (0)
Introduction for SEPSIS (1998) (0)
OS 02-05 MYD88 ON MACROPHAGE TRIGGERS CATHEPSIN L ACTIVATION DRIVEN VASCULAR INTIMAL HYPERPLASIA (2016) (0)
LIPOPOLYSACCHARIDE (LPS) UPTAKE INTO LIVER HEPATOCYTES (HC) IN VIVO IS CD14-DEPENDENT (2006) (0)
CXCL12 (SDF-1)-CXCR4 Plays a Key Role in B-Cell Trafficking after Hemorrhagic Shock and Trauma in Mice (2015) (0)
Toll-like receptor 4 (TLR4) on hepatocytes mediates high mobility group box-1 (HMGB1) release after hepatic ischemia reperfusion in a JNK-dependent manner (2012) (0)
Transgene is tightly regulated by Geneswitch system in 293 cells (2007) (0)
Hepatic dysfunction after shock: Clinical parameters and biological pathways for therapeutic intervention (2009) (0)
Principal component analysis delineates both subgroup- and patient-specific insights into acute inflammation in trauma patients (2009) (0)
Chapter 32 – Nitric Oxide Synthase Gene Transfer (2000) (0)
FADD is Initially Located in the Mitochondria in TNF Mediated Apoptosis in Rat Hepatocytes (2006) (0)
A GENE ONTOLOGY AND NETWORK-BASED ANALYSIS OF MURINE LIVER IN TRAUMATIC-HEMORRHAGIC SHOCK (2006) (0)
INDUCTION OF LIPOPOLYSACCHARIDE BINDING PROTEIN mRNA IN CULTURED RAT PULMONARY ARTERY SMOOTH MUSCLE CELLS BY INTERLEUKIN-l?? (1994) (0)
Caspase-11 regulates HMGB1 release from liver during polymicrobial sepsis (INM2P.348) (2015) (0)
iNOS Overexpression and Inhibition of Vascular Smooth Muscle Cell Proliferation (1999) (0)
Dynamic Bayesian Network Analysis of Inflammation Biomarkers Reveals Age-Related Changes of the Inflammatory Response after Trauma (2018) (0)
High-mobility group box 1 inhibition protects against hepatic ischemia-reperfusion injury (2004) (0)
68. Mechanisms of Toll-Like Receptor 4- Mediated Inflammation After Cold Ischemia/Reperfusion (I/R)Role of CD14 and HMGB1 (2008) (0)
Hepatocyte acute-phase response is dependent on HMGB1 (2012) (0)
Early growth response-1 (EGR-1) expression in the liver in hemorrhagic shock (HS) is localized to hepatocytes and upregulated by hypoxia or reactive oxygen species (ROS) exposure in vitro (2004) (0)

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Other Resources About Timothy Billiar

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What Schools Are Affiliated With Timothy Billiar?

Timothy Billiar is affiliated with the following schools:

Central South University
Doane University
Hannover Medical School
Carnegie Mellon University
University of Chicago
University of Pittsburgh
King's College London