Alfred G. Gilman | Academic Influence

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Alfred G. Gilman

Medical

#57

World Rank

#99

Historical Rank

#29

USA Rank

Pharmacology

#8

World Rank

#12

Historical Rank

#5

USA Rank

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Alfred G. Gilman's Degrees

PhD Pharmacology Case Western Reserve University

Why Is Alfred G. Gilman Influential?

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According to Wikipedia, Alfred Goodman Gilman was an American pharmacologist and biochemist. He and Martin Rodbell shared the 1994 Nobel Prize in Physiology or Medicine "for their discovery of G-proteins and the role of these proteins in signal transduction in cells."

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Alfred G. Gilman's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

G proteins: transducers of receptor-generated signals. (1987) (5804)
A protein binding assay for adenosine 3':5'-cyclic monophosphate. (1970) (2761)
G proteins and dual control of adenylate cyclase (1984) (1507)
The structure of the G protein heterotrimer Giα1 β 1 γ 2 (1995) (1014)
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. (1991) (902)
Complexity and diversity of mammalian adenylyl cyclases. (1996) (890)
p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13 (1998) (834)
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. (1998) (832)
Biochemical properties of hormone-sensitive adenylate cyclase. (1980) (818)
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. (1994) (802)
Structure of RGS4 Bound to AlF4 −-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis (1997) (758)
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. (1997) (730)
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits (1996) (711)
Mammalian Membrane-bound Adenylyl Cyclases (*) (1995) (689)
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. (1989) (679)
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. (1985) (643)
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. (1982) (544)
G protein involvement in receptor-effector coupling. (1988) (530)
Cyclic Adenosine Monophosphate and Alteration of Chinese Hamster Ovary Cell Morphology: a Rapid, Sensitive In Vitro Assay for the Enterotoxins of Vibrio cholerae and Escherichia coli (1974) (508)
Mammalian RGS Proteins: Barbarians at the Gate* (1998) (508)
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. (1983) (461)
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. (1986) (451)
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel (1994) (428)
Homologies between signal transducing G proteins and ras gene products. (1984) (410)
Expression and characterization of calmodulin-activated (type I) adenylylcyclase. (1991) (389)
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. (1995) (379)
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. (1982) (378)
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. (1984) (374)
Inhibition of adenylyl cyclase by Gi alpha. (1993) (373)
A Cytoplasmic Acyl-Protein Thioesterase That Removes Palmitate from G Protein α Subunits and p21RAS * (1998) (366)
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. (1997) (362)
G proteins control diverse pathways of transmembrane signaling 1 (1989) (362)
Purification and characterization of smooth muscle cell caveolae (1994) (349)
The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis* (1996) (347)
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin (1984) (343)
The regulatory component of adenylate cyclase. Purification and properties. (1981) (342)
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. (1984) (339)
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. (1978) (339)
Relationship between the beta-adrenergic receptor and adenylate cyclase. (1977) (339)
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. (1994) (337)
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2* (1999) (332)
Cloning and expression of a widely distributed (type IV) adenylyl cyclase. (1991) (326)
G proteins. (1992) (321)
Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits (1995) (320)
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. (1984) (313)
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. (1987) (310)
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity (1998) (309)
Crystal structure of the adenylyl cyclase activator Gsalpha. (1997) (308)
Mammalian Ric-8A (Synembryn) Is a Heterotrimeric Gα Protein Guanine Nucleotide Exchange Factor* (2003) (303)
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. (1984) (303)
Two-metal-Ion catalysis in adenylyl cyclase. (1999) (300)
Lipid modifications of G proteins: alpha subunits are palmitoylated. (1993) (292)
G proteins and regulation of adenylyl cyclase (1989) (289)
Tertiary and Quaternary Structural Changes in Giα1 Induced by GTP Hydrolysis (1995) (286)
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. (1983) (283)
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. (1986) (266)
Molecular basis for two forms of the G protein that stimulates adenylate cyclase. (1986) (266)
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. (1984) (264)
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. (1991) (261)
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. (1992) (258)
Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits. (1993) (258)
An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. (1976) (255)
A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits (1998) (248)
Expression of G-protein alpha subunits in Escherichia coli. (1994) (242)
Gz, a guanine nucleotide-binding protein with unique biochemical properties. (1990) (235)
GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain* (1998) (225)
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. (1993) (224)
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. (1996) (221)
Organization of G proteins and adenylyl cyclase at the plasma membrane. (1997) (217)
Exchange of Substrate and Inhibitor Specificities between Adenylyl and Guanylyl Cyclases* (1998) (215)
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. (1971) (214)
Resolution of some components of adenylate cyclase necessary for catalytic activity. (1977) (212)
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. (1984) (209)
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. (1986) (208)
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. (1998) (207)
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. (1990) (206)
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. (1987) (204)
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. (1983) (204)
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. (1989) (203)
Receptor regulation of G-protein palmitoylation. (1994) (200)
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. (1989) (199)
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. (1991) (199)
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. (1987) (195)
Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins. (1985) (190)
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. (1995) (185)
Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase* (1997) (179)
Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. (1997) (179)
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. (1989) (178)
Autoacylation of G Protein α Subunits* (1996) (176)
Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. (1976) (173)
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins. (1987) (170)
Adenylyl cyclases (1992) (168)
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. (1985) (167)
ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits. (1984) (162)
G protein βγ subunits: Simplified purification and properties of novel isoforms (1994) (162)
G protein gamma subunits contain a 20-carbon isoprenoid. (1990) (161)
Identification of a Giα Binding Site on Type V Adenylyl Cyclase* (1998) (160)
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. (1983) (158)
Regulation of Adenosine 3′,5′-Cyclic Monophosphate Metabolism in Cultured Neuroblastoma Cells (1971) (149)
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. (1977) (147)
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. (1989) (139)
Functional Importance of the Amino Terminus of G(*) (1996) (136)
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. (1990) (135)
Interaction of the two cytosolic domains of mammalian adenylyl cyclase. (1996) (135)
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. (1992) (135)
The Catalytic Mechanism of Mammalian Adenylyl Cyclase (1997) (133)
Allosteric determinants in guanine nucleotide-binding proteins (2003) (133)
Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles. (1984) (131)
Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins (1992) (128)
Regulators of G Protein Signaling 6 and 7 (1999) (126)
The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits. (1992) (126)
Overview of the Alliance for Cellular Signaling (2002) (125)
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase. (1982) (122)
Interactions of Forskolin and ATP with the Cytosolic Domains of Mammalian Adenylyl Cyclase* (1997) (122)
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. (1986) (120)
Truncation and alanine-scanning mutants of type I adenylyl cyclase. (1995) (120)
Activation of phospholipase C-β2 mutants by G protein αq and βγ subunits (1993) (118)
Mechanism of GTP hydrolysis by G-protein alpha subunits. (1994) (118)
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase* (1998) (115)
beta-Adrenergic receptor: ligand binding properties and the interaction with adenylyl cyclase. (1977) (115)
Molecular basis for P-site inhibition of adenylyl cyclase. (2000) (114)
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes. (1977) (113)
Targeted Knockdown of G Protein Subunits Selectively Prevents Receptor-mediated Modulation of Effectors and Reveals Complex Changes in Non-targeted Signaling Proteins* (2006) (112)
Inhibition of an inwardly rectifying K+ channel by G-protein α-subunits (1996) (111)
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell. (1979) (111)
Giα and Gβ subunits both define selectivity of G protein activation by α2-adrenergic receptors (2006) (110)
Characterization of Saccharomyces cerevisiaeAcyl-protein Thioesterase 1, the Enzyme Responsible for G Protein α Subunit Deacylation in Vivo * (2002) (109)
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. (1994) (106)
Guanine nucleotide-binding regulatory proteins; mediators of transmembrane signaling (1987) (103)
Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. (1988) (103)
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. (1977) (102)
The interactions of adenylate cyclases with P-site inhibitors. (1999) (101)
The importance of G-protein βλ subunits (1993) (100)
Purification and Characterization of a Soluble Form of Mammalian Adenylyl Cyclase* (1996) (98)
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. (1984) (95)
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. (1989) (92)
[19] Synthetic peptide antisera with determined specificity for G protein α or β subunits (1991) (92)
Sites Important for PLCβ2 Activation by the G Protein βγ Subunit Map to the Sides of the β Propeller Structure* (1998) (90)
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. (1979) (87)
Adenosine cyclic 3',5'-monophosphate in fetal rat brain cell cultures. I. Effect of catecholamines. (1972) (86)
Protein Kinase C Phosphorylates G12α and Inhibits Its Interaction with Gβγ(*) (1996) (86)
Persistent membrane association of activated and depalmitoylated G protein α subunits (1999) (85)
A second form of the beta subunit of signal-transducing G proteins. (1987) (85)
Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. (1976) (83)
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (1998) (83)
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. (1987) (81)
A Candidate Target for G Protein Action in Brain* (1999) (81)
Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue. (1999) (81)
The A326S Mutant of Giα1 as an Approximation of the Receptor-bound State* (1998) (81)
Regulation of Dynamin I GTPase Activity by G Protein βγ Subunits and Phosphatidylinositol 4,5-Bisphosphate* (1996) (80)
Resistance to inhibitors of cholinesterase 8A catalyzes release of Gαi-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Gαi-GDP complexes (2005) (78)
Factors influencing adenosine 3',5'-phosphate accumulation in bovine thyroid slices. (1968) (77)
Receptor-regulated G proteins (1986) (77)
Nobel Lecture. G proteins and regulation of adenylyl cyclase. (1995) (75)
Assay of cyclic nucleotides by receptor protein binding displacement. (1974) (72)
Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1. (1997) (70)
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. (1993) (70)
Autoacylation of G protein alpha subunits. (1996) (69)
Beta adrenergic receptors and adenylate cyclase: products of separate genes? (1976) (67)
Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase. (1991) (65)
Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity. (1984) (63)
A Protein BindingAssayforAdenosine 3':5'-Cyclic Monophosphate (1970) (63)
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-. (1991) (62)
Norepinephrine Stimulated Increase of Cyclic AMP Levels in Developing Mouse Brain Cell Cultures (1971) (62)
Protein binding assays for cyclic nucleotides. (1972) (62)
Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases. (1996) (60)
Fluorescent Modification of Adenosine 3',5'-Monophosphate: Spectroscopic Properties and Activity in Enzyme Systems (1972) (60)
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. (1995) (59)
The Albert Lasker Medical Awards. G proteins and regulation of adenylyl cyclase. (1989) (54)
Activation of transducin guanosine triphosphatase by two proteins of the RGS family. (1997) (54)
Cyclic Adenosine Monophosphate andAlteration ofChinese Hamster OvaryCellMorphology: aRapid, Sensitive InVitro AssayfortheEnterotoxins ofVibrio cholerae and Escherichia coli (1974) (52)
Hydrodynamic properties of the regulatory component of adenylate cyclase. (1980) (51)
The Reaction of [3H]Norepinephrine with Particulate Fractions of Cells Responsive to Catecholamines (1974) (51)
Sequestration of the G protein βγ subunit complex inhibits receptor-mediated endocytosis (1998) (49)
Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors. (2006) (49)
Structure of the GDP–Pi complex of Gly203→Ala Giα1: a mimic of the ternary product complex of Gα-catalyzed GTP hydrolysis (1996) (49)
Crystallization and preliminary crystallographic studies of Giα1 and mutants of Giα1 in the GTP and GDP-bound states (1994) (45)
Regulation of adenylyl cyclase by G proteins. (1990) (44)
Gia1: Stabilization of the Transition State for GTP Hydrolysis (1997) (44)
TAO (Thousand-and-one Amino Acid) Protein Kinases Mediate Signaling from Carbachol to p38 Mitogen-activated Protein Kinase and Ternary Complex Factors* (2003) (42)
Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. (2005) (41)
Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits. (1993) (40)
Role of G proteins in transmembrane signaling. (1988) (39)
Time Resolved Kinetics of Direct Gβ1γ2 Interactions with the Carboxyl Terminus of Kir3.4 Inward Rectifier K+ Channel Subunits (1996) (39)
Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase. (1978) (39)
Regulation of mammalian adenylyl cyclases by G-protein α and βγ subunits (1992) (38)
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells. (1973) (38)
Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase. (1997) (37)
Inhibition of an inwardly rectifying K+ channel by G-protein α-subunits (1996) (36)
G proteins. (1992) (36)
Adenylate cyclase assay with adenylyl imidodiphosphate and product detection by competitive protein binding. (1974) (34)
The role of adenosine 3',5'-phosphate in mediating effects of thyroid-stimulating hormone on carbohydrate metabolism of bovine thyroid slices. (1968) (34)
Erratum: Inhibition of an inwardly rectifying K+ channel by G-protein α-subunits (Nature (1996) 380 (624-627)) (1996) (32)
G Proteins and Regulation of Adenylate Cyclase (Nobel Lecture) (1995) (32)
G-protein a-subunit expression , myristoylation , and membrane association in COS cells ( protein N-myristoylation / fatty acid analog ) (31)
Synthetic peptide antisera with determined specificity for G protein alpha or beta subunits. (1991) (31)
Expression of Gsα in Escherichia coli: purification and properties of two forms of the protein (1989) (31)
The G protein β2 complementary DNA encodes the β35 subunit (1987) (29)
Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: a simultaneous protein binding assay. (1971) (28)
[17] Purification of recombinant Gsα (1991) (27)
Lipid Modifications of G Protein Subunits MYRISTOYLATION OF Go, INCREASES ITS AFFINITY FOR By* (2001) (26)
Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins. (1992) (25)
Control of adenylate cyclase activity by G proteins. (1985) (25)
Regulation of dynamin I GTPase activity by G protein betagamma subunits and phosphatidylinositol 4,5-bisphosphate. (1996) (24)
G protein beta gamma subunits. Simplified purification and properties of novel isoforms. (1994) (24)
Assay of RGS protein activity in vitro using purified components. (2002) (24)
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. II. Effects of prostaglandin E1 and theophylline on parental and hybrid cells. (1973) (23)
Characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase. (1982) (23)
Frustration and adenylate cyclase. (1975) (23)
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits. (1996) (21)
Role of the β-Adrenergic Receptor in the Regulation of Adenylate Cyclase (1984) (21)
Purification and functional analysis of Ric-8A: A guanine nucleotide exchange factor for G-protein α subunits (2004) (20)
Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma. (1996) (20)
[18] Purification of recombinant G1α and Goα proteins from Escherichia coli (1991) (19)
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells. (1977) (19)
[16] Purification of recombinant G(q)α, G11α, and G16α from Sf9 cells (1994) (17)
Isolation and Characterization of Constitutively Active Mutants of Mammalian Adenylyl Cyclase* (2000) (17)
Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants of Gi alpha 1 in the GTP and GDP-bound states. (1994) (17)
Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides (1975) (16)
Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis. (1998) (16)
Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. (1996) (16)
Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. (2002) (14)
Expression and purification of recombinant adenylyl cyclases in Sf9 cells. (1994) (14)
Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure. (1998) (13)
PURIFICATION OF COMPLEXES WITH Gb5 AND ASSESSMENT OF THEIR EFFECTS ON G PROTEIN- MEDIATED SIGNALING PATHWAYS* (1999) (12)
Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. (1991) (12)
Guanine-Nucleotide-Binding Regulatory Proteins (1985) (12)
Transmembrane signaling, G proteins, and adenylyl cyclase. (1989) (11)
The guanine nucleotide-binding regulatory component of adenylate cyclase in human erythrocytes. (1982) (11)
Persistent membrane association of activated and depalmitoylated G protein alpha subunits. (1999) (10)
Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits. (1992) (9)
Purification and functional analysis of Ric-8A: a guanine nucleotide exchange factor for G-protein alpha subunits. (2004) (9)
Synthesis in .Escherichia coli of GTPase-deficient Mutants of Gsa* (2001) (8)
Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells. (1994) (8)
Silver spoons and other personal reflections. (2012) (8)
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gs a z GTP g S (1997) (7)
Purification of recombinant Gi alpha and Go alpha proteins from Escherichia coli. (1991) (7)
Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures. (1971) (7)
Regulation of cyclic AMP metabolism in cultured cells of the nervous system. (1972) (7)
Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. (2002) (7)
Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits. (1996) (7)
Transduction Proteins of Olfactory Receptor Cells (1987) (5)
Hormonal control of cyclic AMP metabolism in parental and hybrid somatic cells. (1975) (5)
G protein y subunits contain a 20-carbon isoprenoid (2004) (5)
The G protein beta 2 complementary DNA encodes the beta 35 subunit. (1987) (4)
G proteins and regulation of adenylyl cyclases (1996) (4)
Elevation of cyclic AMP content of rat brain cell cultures by adenosine (1973) (4)
Hormone receptors and the control of cyclic AMP metabolism in parental and hybrid somatic cells. (1976) (3)
Prostaglandin e1 (pge1) receptors and adenylate cyclase (ac) in cultured mammalian cells. Abstr. (1976) (3)
The importance of G-protein beta lambda subunits. (1993) (2)
Purification of recombinant Gs alpha. (1991) (2)
ADP-ribosylation of G , Promotes the Dissociation of Its Q! and p Subunits* (2001) (2)
Reconstitution of catecholamine-sensitive adenylate cyclase activity : Interaction of solubilized components with receptor-replete membranes ( S 49 lymphoma / L cell / complementation in vitro / somatic cell variants ) (2)
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S 49 mouse lymphoma cells ( P-adrenergic receptor / catecholamines / prostaglandins / guanine nucleotides ) (2)
Wrong signals about alliance's scope and aim (2000) (2)
The 'news' URL scheme (1998) (1)
Structural and Biochemical Characterization of the GTP γ S-, GDP ‚ Pi-, and GDP-Bound Forms of a GTPase-Deficient Gly 42 f Val Mutant of Gi R 1 † (1997) (1)
The crystallographic structure of a G protein heterotrimer (1996) (1)
Expression of cDNAs for G Proteins in Escherichia coli TWO FORMS OF G., STIMULATE ADENYLATE CYCLASE* (2001) (1)
PURIFICATION AND PROPERTIES OF THE REGULATORY COMPONENT OF ADENYLATE CYCLASE (1981) (1)
Regulation of adenosine 3',5' cyclic monophosphate metabolism in hybrid somatic cells (1973) (1)
Identification and partial characterization of some components of hormone-stimulated adenylate cyclase. (1979) (1)
Guanine nucleotide-binding regulatory proteins: a family of membrane-bound transducers (1984) (1)
Erratum: Purification and characterization of a soluble form of mammalian adenylyl cyclase (Journal of Biological Chemistry (1996) 271 (16967-16974)) (1996) (1)
Goodman & Gilman Dasar Farmakologi Terapi vol.1 Ed 10 (2012) (1)
David L. Garbers (1944–2006) (2007) (1)
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT (1998) (0)
Physicochemical properties of the β-adrenergic receptor and adenylate cyclase (1978) (0)
Gi (cid:1) and G (cid:2) subunits both define selectivity of G protein activation by (cid:1) 2-adrenergic receptors (2005) (0)
Molecular sizes of putative β adrenergic receptor and adenylate cyclase (1977) (0)
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG (2001) (0)
Structural insights into G protein regulation (1998) (0)
ADP-RIBOSYLATION OF THE REGULATORY COMPONENTS OF ADENYLATE CYCLASE1,2 (1983) (0)
Hydrodynamic Properties of the P-Adrenergic Receptor and Adenylate Cyclase from Wild Type and Variant S 49 Lymphoma Cells * (2002) (0)
Effect of 2 Cl adenosine on cyclic AMP concentrations of cultured cells (1974) (0)
Purification and characterization of recombinant G 16 a from Sf 9 cells : Activation of purified phospholipase C isozymes by G-protein ca subunits (0)
Resistance to inhibitors of cholinesterase 8A catalyzes release of G (cid:1) i-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA (cid:1) LGN (cid:1) G (cid:1) i-GDP complexes (2005) (0)
GTP-GAMMA-S BOUND G42V GIA1 (1997) (0)
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG (2001) (0)
Deduced primary structure of the cr-subunit of the GTP-binding stimulatory protein of adenylate cyclase (guanine nucleotide-binding regulatory proteins/transducin/ras proteins) (2016) (0)
G PR.OTEINS: TRANSDUCERS OF RECEPTOR-GENERAT ED SIGNALS (1987) (0)
Hormone receptors uncoupled from adenylate cyclase (AC) in a variant S49 lymphoma cell clone (1977) (0)
GDP BOUND G42V GIA1 (1997) (0)
Correction: 1996 Bayer Lecture. Visualizing signal tranduction: Receptors, G-proteins, and adenylate cyclases (Clinical Science (1996) 91 (527-537)) (1997) (0)
GDP+PI BOUND G42V GIA1 (1997) (0)
(guanine nucleotide-binding regulatory proteins/adenylyl cyclase) (0)
Will cell alliance breed bureaucracy and leave contributors out? (2000) (0)
Covalent reaction of 3H norepinephrine with particulate fractions of cells responsive to catecholamines (1974) (0)
Catecholamine-Sensitive Adenylate Cyclase: Identification and Partial Characterization of Some of its Components* (1979) (0)
OPENING REMARKS (1965) (0)
Contents Silver Spoons and Other Personal Reflections (2013) (0)
Expression of genes for metabolism of adenosine 3', 5'-cyclic monophosphate in somatic cells (1973) (0)
Newsmaker interview. Texas transplant Alfred Gilman guides $3 billion cancer project. Interview by Jocelyn Kaiser. (2009) (0)
Purified Phospholipase C Isozymes by G-Protein { alpha } Subunits Purification and Characterization of Recombinant G 16 { alpha } From Sf 9 Cells : Activation of T Kozasa , (2005) (0)
Structural insights into g-protein signalling (1997) (0)

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