Avram Hershko
#992
Most Influential Person Now
Israeli scientist
Avram Hershko's AcademicInfluence.com Rankings
Avram Hershkobiology Degrees
Biology
#182
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#332
Historical Rank
Cell Biology
#113
World Rank
#118
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Biochemistry
#103
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#132
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Neuroscience
#947
World Rank
#986
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Chemistry Biology
Why Is Avram Hershko Influential?
(Suggest an Edit or Addition)According to Wikipedia, Avram Hershko is a Hungarian-Israeli biochemist who received the Nobel Prize in Chemistry in 2004. Biography He was born Herskó Ferenc in Karcag, Hungary, into a Jewish family, the son of Shoshana/Margit 'Manci' and Moshe Hershko, both teachers. During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into labor until the end of the war. Avram and his mother survived the war and returned to their home. His father returned as well, 4 years after they had last seen him.
Avram Hershko's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The ubiquitin system (2000) (4544)
- SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 (1999) (1536)
- The ubiquitin system for protein degradation. (1992) (1342)
- Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. (1983) (1011)
- The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. (1995) (808)
- Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. (1999) (677)
- Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. (1980) (651)
- A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. (1978) (547)
- Mechanisms of intracellular protein breakdown. (1982) (515)
- Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* (2003) (492)
- The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 (2001) (488)
- ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. (1980) (468)
- Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage (2003) (401)
- Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. (1982) (377)
- Ubiquitin-mediated protein degradation. (1988) (373)
- Roles of ubiquitin-mediated proteolysis in cell cycle control. (1997) (361)
- The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle* (2005) (335)
- ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. (1989) (306)
- Ubiquitin: Roles in protein modification and breakdown (1983) (273)
- "Covalent affinity" purification of ubiquitin-activating enzyme. (1982) (268)
- Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. (1982) (257)
- Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. (1971) (238)
- Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2. (1994) (234)
- Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. (2003) (230)
- Basic Medical Research Award. The ubiquitin system. (2000) (228)
- Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. (1991) (226)
- Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. (1997) (220)
- Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (2004) (219)
- Dual mode of degradation of Cdc25 A phosphatase (2002) (217)
- Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. (1980) (212)
- Past, Present, and Future Perspectives (1998) (208)
- Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. (1981) (206)
- Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. (1985) (205)
- Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. (1995) (201)
- Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas (2001) (198)
- The Cyclin-Ubiquitin Ligase Activity of Cyclosome/APC Is Jointly Activated by Protein Kinases Cdk1-Cyclin B and Plk* (2002) (198)
- ATP-dependent degradation of ubiquitin-protein conjugates. (1984) (196)
- Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. (1979) (192)
- Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. (1984) (191)
- Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. (1987) (181)
- The mouse and human genes encoding the recognition component of the N-end rule pathway. (1998) (170)
- The ubiquitin pathway for the degradation of intracellular proteins. (1986) (168)
- SKP 2 is required for ubiquitin-mediated degradation of the CDK inhibitor p 27 (1999) (162)
- Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. (1999) (157)
- A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. (1992) (150)
- The protein substrate binding site of the ubiquitin-protein ligase system. (1986) (150)
- The ubiquitin pathway for protein degradation. (1991) (147)
- Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. (2006) (141)
- E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. (1996) (135)
- Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. (2000) (127)
- Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex. (1993) (127)
- A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation. (1988) (122)
- Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. (1981) (113)
- Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit (2008) (110)
- Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites. (1988) (108)
- Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet (2014) (107)
- Mechanisms and regulation of the degradation of cyclin B. (1999) (106)
- p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process (2011) (100)
- The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture). (2005) (95)
- Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. (1975) (93)
- Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation* (2002) (91)
- Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint (2007) (83)
- Post-translational cleavage of polypeptide chains: role in assembly. (1975) (81)
- Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity. (1990) (77)
- Lessons from the discovery ofthe ubiquitin system (1996) (74)
- Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding (2006) (69)
- "Pleiotypic response". (1971) (67)
- Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells. (1976) (65)
- Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein. (1989) (60)
- Binding of Activated Cyclosome to p13 suc1 (1997) (57)
- Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme. (1990) (57)
- ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint (2010) (55)
- Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway. (1988) (54)
- Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes (2015) (49)
- A ubiquitin-protein ligase specific for type III protein substrates. (1990) (47)
- A high molecular weight protease in liver cytosol. (1979) (44)
- Lessons from the discovery of the ubiquitin system. (1996) (43)
- Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes (2017) (42)
- Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B. (1999) (40)
- Hierarchical order of phosphorylation events commits Cdc25A to Beta-TrCP-dependent degradation (2004) (38)
- MODE OF DEGRADATION OF ABNORMAL GLOBIN CHAINS IN RABBIT RETICULOCYTES (1978) (37)
- The pleiotypic response in mammalian cells: search for an intracellular mediator. (1972) (36)
- Regulation of the Action of Early Mitotic Inhibitor 1 on the Anaphase-promoting Complex/Cyclosome by Cyclin-dependent Kinases* (2011) (33)
- Role of the SCF Skp2 Ubiquitin Ligase in the Degradation of p21 Cip1 in S Phase* (2003) (31)
- Protein turnover in senescent cultured chick embryo fibroblasts (1978) (31)
- Role of phosphorylation of Cdc20 in p31comet-stimulated disassembly of the mitotic checkpoint complex (2012) (30)
- Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20 (2008) (26)
- Studies on amino acid control of cellular function (1974) (25)
- Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli. (1973) (24)
- Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly (2013) (24)
- Mechanisms and regulation of ubiquitin-mediated cyclin degradation. (1996) (21)
- Regulation of APC/CCdh1 ubiquitin ligase in differentiation of human embryonic stem cells (2010) (21)
- The Ubiquitin System for Protein Degradation and Some of Its Roles in the Control of the Cell‐Division Cycle Nobel Lecture (2006) (19)
- Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells. (2010) (17)
- Regulation of intracellular protein breakdown in stringent and relaxed strains of E. coli,. (1974) (17)
- Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts. (1976) (16)
- A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978. (2012) (16)
- Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex (2016) (14)
- Alterations in components of the ubiquitin-protein ligase system following maturation of reticulocytes to erythrocytes. (1987) (14)
- Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome (2018) (12)
- Early work on the ubiquitin proteasome system, an interview with Avram Hershko (2005) (11)
- Role of Polo-like kinase 1 in the regulation of the action of p31comet in the disassembly of mitotic checkpoint complexes (2019) (11)
- Roles of protein synthesis and tRNA aminoacylation in the regulation of intracellular protein breakdown in E. coli. (1974) (10)
- The ubiquitin pathway of protein degradation and proteolysis of ubiquitin-protein conjugates. (1991) (9)
- Interconversion of multiple forms of tyrosine aminotransferase in vitro and in vivo in cultured hepatoma cells. (1977) (9)
- Mode of interaction of purine nucleotides and amino acids with glutamate dehydrogenase. (1966) (8)
- Role of the a-amino group of protein in ubiquitin-mediated protein breakdown ( protein turnover / conjugation / amino terminus / N-acetylation ) (8)
- THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION (1996) (7)
- Some Lessons from My Work on the Biochemistry of the Ubiquitin System (2009) (7)
- The ATP-ubiquitin proteolytic pathway. (1985) (5)
- Relevance of protease "inhibitor" to the ATP-ubiquitin proteolytic system. (1984) (5)
- Preparation of clam oocyte extracts for cell cycle studies. (1997) (5)
- Selectivity of Ubiquitin-Mediated Protein Breakdown (1988) (5)
- Affinity purification of mitotic anaphase-promoting complex/cyclosome on p13Suc1. (2005) (4)
- From Rabbit Reticulocytes to Clam Oocytes: In Search of the System That Targets Mitotic Cyclins for Degradation (2010) (4)
- Israel–Gaza conflict (2014) (3)
- Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes (2022) (3)
- Influence of ATP depletion on the degradation of rapidly labeled RNA in cultured hepatoma cells. (1975) (3)
- The Ubiquitin System for Protein Degradation and Some of Its Roles in the Control of the Cell‐Division Cycle (Nobel Lecture) (2005) (2)
- Science as an Adventure - Lessons for the Young Scientist* (2010) (2)
- Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis (2022) (2)
- Recombinant Protease Inhibitor Enhances Oral Insulin Pharmacodynamics in Pigs (2018) (1)
- Brief History of Protein Degradation and the Ubiquitin System (2005) (1)
- The Ubiquitin System and Some of Its Roles in Cell Cycle Control (2002) (1)
- Molecular Mechanisms that Maintain Genome Stability in Human Cells (2007) (1)
- Proceedings: Energy requirement of the breakdown of RNA in cultured hepatoma cells. (1975) (1)
- Award for the ubiquitin pathway (2000) (0)
- Attempt On Utilization of Aqueous Solution of Eurhodin Treated Mulberry Leaves for the Qualitative Cocoons and Silk Filament in silkworm, Bombyx mori (L) Races: Bivoltine Cross Breed [(CSR6 x CSR26) x CSR2 x CSR27)] and multivoltine crossbreed [(PM x CSR (2018) (0)
- ATP-dependent conjugation of retic polypeptide required for protein de! (protein/breakdown/energy requirement/covalent linkage of poly (2016) (0)
- Inhibitors of the Ubiquitin-Proteasome System as Potential Therapeutic Agents for Cardiovascular Diseases (2008) (0)
- Control of biochemical processes associated with cellular growth by insulin in transformed and untransformed cultured mouse fibroblasts. (1972) (0)
- Celebrating the death of proteins (2004) (0)
- Ubiquitin-aldehyde: A general inhil recycling processes (2016) (0)
- Attempt on Magnification of the Mechanism of Enzyme Catalyzed Reaction through Bio-geometric Model for the Five Points Circle in the Triangular Form of Lineweaver-Burk Plot (2020) (0)
- Coordinate control of macromolecular metabolism by serum and insulin in transformed and ultratransformed cultured mouse fibroblasts. Abstr. (1971) (0)
- MULBERRY, MORUS ALBA (L): THE GLOBAL MEDICINAL HERITAGE (2018) (0)
- History of Protein Degradation and the Ubiquitin System (2005) (0)
- Specificity of Binding of NHa-terminal Residue of Proteins to Ubiquitin-Protein Ligase USE OF AMINO ACID DERIVATIVES TO CHARACTERIZE SPECIFIC BINDING (2001) (0)
- Ubiquitin-mediated proteolysis The Nobel Prize in Chemistry for 2004 is shared between three scientists who have made fundamental discoveries concerning how cells regulate the breakdown of intracellular proteins with extreme specificity as to target, time and space (2004) (0)
- Altered activity of the APC/CCdh1 complex controls Skp2 expression in differentiating human embryonic stem cells (hESc) (2009) (0)
- Irwin Allan Rose (1926–2015) (2015) (0)
- What history tells us XLI. Ubiquitin and proteolysis (2016) (0)
- Ubiquitin-mediated protein degradation: The early days The ubiquitin system (2000) (0)
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