Candace Pert
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American neuroscientist
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#76
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Candace Pert's Degrees
- Bachelors Biology Bryn Mawr College
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(Suggest an Edit or Addition)According to Wikipedia, Candace Beebe Pert was an American neuroscientist and pharmacologist who discovered the opioid receptor, the cellular binding site for endorphins in the brain. Early life and education She was born on June 26, 1946, in Manhattan, New York City.
Candace Pert's Published Works
Published Works
- Opiate Receptor: Demonstration in Nervous Tissue (1973) (2324)
- Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain (1973) (775)
- Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section (1976) (625)
- Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide (1988) (620)
- Opiate receptor: autoradiographic localization in rat brain. (1976) (587)
- Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium (1974) (545)
- Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum (1981) (532)
- Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain (1973) (502)
- beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). (1978) (471)
- Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality (1982) (464)
- Visualization and characterization of interleukin 1 receptors in brain. (1987) (440)
- Properties of opiate-receptor binding in rat brain. (1973) (405)
- Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas (1986) (398)
- Autoradiographic localization of the opiate receptor in rat brain (1975) (375)
- Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. (1988) (261)
- Autoradiographic distribution of nicotine receptors in rat brain (1984) (260)
- Neuropeptides and their receptors: a psychosomatic network. (1985) (240)
- Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film. (1981) (238)
- Benzodiazepine receptor-mediated chemotaxis of human monocytes. (1985) (235)
- Autoradiographic distribution of substance P receptors in rat central nervous system (1983) (229)
- Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. (1986) (227)
- Substance P receptor-mediated chemotaxis of human monocytes (1985) (213)
- Ontogenetic development of [3H]naloxone binding in rat brain (1976) (211)
- Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. (1985) (211)
- Ontogeny of opiate receptors in rat forebrain: visualization by in vitro autoradiography. (1981) (209)
- Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells. (1978) (207)
- Molecules Of Emotion (1997) (174)
- In vitro autoradiography of opiate receptors in rat brain suggests loci of "opiatergic" pathways. (1980) (173)
- Phylogenetic distribution of opiate receptor binding. (1974) (172)
- Vasoactive intestinal polypeptide: specific binding to rat brain membranes. (1979) (172)
- Autoradiographic distribution of [3H]neurotensin receptors in rat brain: Visualization by tritium-sensitive film (1982) (167)
- Bombesin: Receptor distribution in brain and effects on nociception and locomotor activity (1980) (165)
- Neuropeptides are chemoattractants for human tumor cells and monocytes: a possible mechanism for metastasis. (1985) (154)
- Is the benzodiazepine receptor coupled to a chloride anion channel? (1979) (153)
- Corticotropin and β-endorphin-like materials are native to unicellular organisms (1982) (149)
- The effect of imipramine and lithium on α- and β-receptor binding in rat brain (1979) (129)
- Interconverting mu and delta forms of the opiate receptor in rat striatal patches. (1981) (127)
- Opiate receptor-mediated chemotaxis of human monocytes (1985) (126)
- Localization of opiate receptor binding in synaptic membranes of rat brain. (1974) (126)
- CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis (1987) (122)
- Characterization and visualization of cholecystokinin receptors in rat brain using [3H]pentagastrin (1983) (122)
- Opiate receptor binding--enhancement by opiate administration in vivo. (1976) (110)
- Naltrexone reduces weight gain, alters “β-endorphin”, and reduces insulin output from pancreatic islets of genetically obese mice (1980) (106)
- Molecules of emotion : why you feel the way you feel (2003) (106)
- Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin. (1984) (105)
- Visualization of rat brain receptors for the neuropeptide, substance P (1984) (104)
- Evidence for an endogenous peptide ligand for the phencyclidine receptor (1984) (100)
- In vivo autoradiography: Visualization of stress-induced changes in opiate receptor occupancy in the rat brain (1984) (98)
- Upregulation of RANTES in psoriatic keratinocytes: a possible pathogenic mechanism for psoriasis. (1999) (98)
- Opiate receptor localization in rat cerebral cortex (1983) (97)
- The psychosomatic network: foundations of mind-body medicine. (1998) (93)
- Are there antibodies against brain in sera from schizophrenic patients? Review and prospectus (1985) (90)
- Alterations in rat central nervous system endorphins following transauricular electroacupuncture (1981) (89)
- Identification of opiate receptor binding in intact animals. (1975) (88)
- Enkephalins, catecholamines, and psychological mood alterations: effects of prolonged exercise. (1987) (86)
- A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site. (1985) (75)
- Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines. (1986) (74)
- Identification and characterization of the opiate receptor in the ciliated protozoan, Tetrahymena (1988) (70)
- PEPTIDE T IN TREATMENT OF AIDS (1987) (70)
- The opiate receptor: a single 110 kDa recognition molecule appears to be conserved in Tetrahymena, leech, and rat (1988) (70)
- Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. (1988) (64)
- High affinity transport of choline into the myenteric plexus of guinea-pig intestine. (1974) (61)
- S‐[18F]Acetylcyclofoxy: a useful probe for the visualization of opiate receptors in living animals (1984) (60)
- Comparison of substance P and enkephalin distribution in rat brain: An overview using radioimmunocytochemistry (1985) (60)
- Opiate receptor binding in rhesus monkey brain: association with limbic structures (1978) (59)
- Dynorphins: Similar relative potencies on μ-, δ- and κ-opiate receptors (1981) (59)
- Coordinate control of corticotropin, β-lipotropin, and β-endorphin release in mouse pituitary cell cultures (1978) (57)
- Cholecystokinin Receptors in Mammalian Brain: A Comparative Characterization and Visualization (1985) (57)
- Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation (2012) (57)
- Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: Evidence for a two-site allosteric model (1984) (56)
- AIDS and its dementia as a neuropeptide disorder: Role of VIP receptor blockade by human immunodeficiency virus envelope (1988) (56)
- Comparative pharmacological properties and autoradiographic distribution of [3H]ethylketocyclazocine binding sites in rat and guinea pig brain. (1983) (56)
- Discrimination by temperature of opiate agonist and antagonist receptor binding. (1975) (55)
- Calcitonin receptors in the rat mesencephalon mediate its analgesic actions: Autoradiographic and behavioral analysis (1985) (55)
- Chemokine receptor 5 antagonist d-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease (2005) (54)
- Peptide t sequences prevent neuronal cell death produced by the envelope protein (gp 120) of the human immunodeficiency virus (1988) (50)
- Chronic phencyclidine treatment decreases phencyclidine and dopamine receptors in rat brain (1982) (48)
- PLASMA BOMBESIN CONCENTRATIONS IN PATIENTS WITH EXTENSIVE SMALL CELL CARCINOMA OF THE LUNG (1982) (47)
- Opiate receptor interactions of benzomorphans in rat brain homogenates. (1976) (47)
- Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T (1992) (46)
- Evolution of striatal opiate receptors (1982) (46)
- VIP and d-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death (1999) (44)
- Stereospecific displacement of [3H]phencyclidine (PCP) receptor binding by an enantiomeric pair of PCP analogs. (1981) (43)
- Some characteristics of the neutrophil receptor for chemotactic peptides (1980) (42)
- Comparison of the substance P- and dynorphin-containing projections to the substantia nigra: a radioimmunocytochemical and biochemical study (1985) (41)
- Demonstration of receptor-mediated chemotaxis by human spermatozoa. A novel quantitative bioassay. (1985) (41)
- Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit. (1989) (40)
- Homologous N-alkylnorketobemidones. Correlation of receptor binding with analgesic potency. (1975) (39)
- Opiate Receptors (1988) (38)
- The wisdom of the receptors: neuropeptides, the emotions, and bodymind. 1986. (2002) (38)
- Cholecystokinin and the immune system: Receptor-mediated chemotaxis of human and rat monocytes (1988) (38)
- Basic and clinical studies of endorphins. (1979) (38)
- Neuronal Uptake of Neurotransmitters and their Precursors: Studies with “Transmitter” Amino Acids and Choline (1973) (37)
- Visualization of cholecystokinin receptors on a subset of human monocytes and in rat spleen (1991) (37)
- Behavioral manipulation of rats causes alterations in opiate receptor occupancy (1979) (36)
- Substance P receptors in rat spleen: characterization and autoradiographic distribution. (1986) (36)
- TYPE 1 AND TYPE 2 OPIATE RECEPTORS: A SUBCLASSIFICATION SCHEME BASED UPON GTP'S DIFFERENTIAL EFFECTS ON BINDING (1980) (36)
- PEPTIDE T[4-8] IS CORE HIV ENVELOPE SEQUENCE REQUIRED FOR CD4 RECEPTOR ATTACHMENT (1987) (35)
- Effect of β-FNA on opiate receptor binding: Preliminary evidence for two types of μ receptors (1983) (35)
- Tritium-sensitive film autoradiography of [3H]cholecystokinin-5/pentagastrin receptors in rat brain. (1983) (35)
- Bombesin in human and guinea pig alveolar macrophages. (1986) (35)
- Autoradiographic localization of a novel peptide binding site in rat brain using the substance P analog, eledoisin (1984) (34)
- Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). (2005) (33)
- HIV gp120 inhibits the somatotropic axis: a possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting. (1998) (33)
- Certain calcium antagonists are potent displacers of [3H]phencyclidine (PCP) binding in rat brain. (1982) (33)
- Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. (2003) (33)
- HIV envelope protein gp120 induces neuropeptide Y receptor-mediated proliferation of vascular smooth muscle cells: relevance to AIDS cardiovascular pathogenesis (1998) (32)
- Phencyclidine ("angel dust") analogs and sigma opiate benzomorphans cause cerebral arterial spasm. (1983) (31)
- Binding of radiolabeled opiates to slide-mounted sections of molded minced rat brain: A novel method for conducting radioreceptor assays (1983) (31)
- Correlation of opiate receptor affinity with analgetic effects of meperidine homologues. (1976) (31)
- Synthesis and binding characteristics of an intrinsically radiolabeled chemotactic acyl tripeptide Nα‐Formyl—norleucyl—leucyl—phenylalanine (1977) (31)
- Scenarios for a viral etiology of schizophrenia. (1988) (30)
- Peptide T blocks GP120/CCR5 chemokine receptor-mediated chemotaxis. (1999) (30)
- IMPROVEMENT IN AIDS PATIENTS ON PEPTIDE T (1989) (29)
- Antibiotics and peptides with agonist and antagonist chemotactic activity. (1978) (26)
- Agonist–antagonist properties of N-allyl-[D-Ala]2-Met-enkephalin (1977) (25)
- Probes for narcotic receptor mediated phenomena. XI: Synthesis of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-fluoromorphinans (foxy and cyclofoxy) as models of opioid ligands suitable for positron emission transaxial tomography (1985) (25)
- Correlation of regional brain metabolism with receptor localization during ketamine anesthesia: combined autoradiographic 2-[3H]deoxy-D-glucose receptor binding technique. (1982) (24)
- Corticotropin and beta-endorphin-like materials are native to unicellular organisms. (1982) (24)
- Biochemical and autoradiographic evidence for type 1 and type 2 opiate receptors. (1980) (24)
- Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). (2001) (23)
- Autoradiographic visualization of sex differences in the pattern and density of opiate receptors in hamster hypothalamus (1987) (22)
- Halide- and gamma-aminobutyric acid-induced enhancement of diazepam receptors in rat brain. Reversal by disulfonic stilbene blockers of anion channels. (1981) (22)
- The distribution of cholecystokinin and vasoactive intestinal peptide in rhesus monkey brain as determined by radioimmunoassay (1983) (21)
- Vasoactive intestinal peptide receptors in rat spleen and brain: A shared communication network (1988) (21)
- Peptide T and psoriasis. (1989) (21)
- AIDS as a neuropeptide disorder: peptide T, VIP, and the HIV receptor. (1988) (20)
- Visualization of cytokine and virus receptors common to the immune and central nervous system. (1987) (19)
- Evolutionary origins of vertebrate hormones: material very similar to adrenocorticotropic hormone, beta-endorphin, and dynorphin in protozoa. (1981) (18)
- Tritiated D‐ala1‐peptide T binding: A pharmacologic basis for the design of drugs which inhibit HIV receptor binding (1988) (17)
- Identification of a domain in cytochrome C that displaces [3H]TCP binding from rat brain membrane receptors: synthesis of beta-neuroprotectin. (1990) (17)
- ANALYSIS OF [3H]NEUROTENSIN RECEPTORS BY COMPUTERIZED DENSITOMETRY: VISUALIZATION OF CENTRAL AND PERIPHERAL NEUROTENSIN RECEPTORS (1982) (17)
- Neuropeptides are Chemoattractants for Human Monocytes and Tumor Cells: A Basis for Mind-Body Communication (1986) (17)
- Dynorphins: similar relative potencies on mu, delta- and kappa-opiate receptors. (1981) (16)
- Peptide T and glucose metabolism in AIDS dementia complex. (1996) (16)
- Autoradiograhic localization of the opiate receptor in rat brain. (1975) (15)
- Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA) (2003) (15)
- Evidence for the Presence of Specific Receptors for N-formyl Chemotactic Peptides on Human Spermatozoa (1986) (15)
- Morphine noncompetitively inhibits [3H]leucine enkephalin binding to membranes lacking type-II delta binding sites: Evidence for a two-site allosteric model (1984) (14)
- Localization of the T4 antigen/AIDS virus receptor in monkey and rat brain: prominence in cortical regions. (1986) (14)
- The opiate receptor. (1974) (13)
- Cerebrospinal fluid from cognitively impaired patient with acquired immunodeficiency syndrome shows gp120-like neuronal killing in vitro. (1989) (13)
- Increased renal neuroleptic binding in spontaneously hypertensive rats. (1980) (13)
- Autoradiographic localization of T4 antigen, the HIV receptor, in human brain. (1987) (12)
- Characterization and autoradiographic distribution of the beta-adrenergic receptor in the rat lung. (1984) (12)
- Regional distribution and density of Thy 1.1 in rat brain and its relation to subpopulations of neurons (1988) (11)
- Tritiated-6-beta-fluoro-6-desoxy-oxymorphone: A highly selective ligand for the opiate mu receptor whose binding is characterized by low nonspecific binding (1984) (11)
- Supersensitivity to GABA's effect on benzodiazepine receptors develops after striatonigral lesions. (1980) (10)
- VIP1–12 Is a Ligand for the CD4/Human Immunodeficiency Virus Receptor (1988) (10)
- Characterization of type 2 opiate receptors. (1982) (10)
- The Mechanism of Opiate Agonist and Antagonist Action (1978) (10)
- 24 – From Receptors to Brain Circuitry (1981) (10)
- Origin of human small cell lung cancer. (1985) (10)
- Co-localization of IGF-II receptors, IL-1 receptors and Thy 1.1 in rat brain (1988) (10)
- Neuromodulation by polypeptide growth factors: preliminary results on the distribution of epidermal growth factor receptors in adult brain. (1988) (9)
- Inhibition of dopamine-activated adenylate cyclase and dopamine binding by opiate receptors in rat striatum (1983) (9)
- Calcitonin inhibits the phosphorylation of various proteins in rat brain synaptic membranes. (1985) (9)
- Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8 (2017) (8)
- Properties of the phencyclidine (PCP) receptors (1983) (8)
- Human monocyte chemotaxis to neuropeptides. (1987) (8)
- Pharmacokinetics of peptide T in patients with Acquired Immunodeficiency Syndrome (AIDS) (1991) (7)
- CATECHOLAMINE RECEPTOR STABILIZATION: A POSSIBLE MODE OF LITHIUM'S ANTI-MANIC ACTION (1979) (7)
- HIV receptor in brain and deduced peptides that block viral infectivity. (1988) (7)
- raf protooncogene expression in neural and immune tissues. (1988) (6)
- Peptide T bolus normalizes the growth hormone secretion pattern in two children with AIDS (2002) (6)
- Structure-activity studies of C- and N-terminal fragments of cholecystokinin 26–33 in guinea pig isolated tissues (1987) (6)
- Profound Anti-HIV-1 Activity of DAPTA in Monocytes/macrophages and Inhibition of CCR5-mediated Apoptosis in Neuronal Cells (2007) (6)
- Ionic conditions differentially affect 3H-DADL binding to type-I and type-II opiate delta receptors in vitro (1984) (6)
- High-affinity substance P binding sites in rat esophagus plexus submucosus. (1987) (5)
- Visualization and solubilization of rat brain opiate receptors with a “κ” ligand selectivity pattern (1982) (5)
- Evidence for the presence of specific receptors for N-formyl chemotactic peptides on human spermatozoa. (1987) (5)
- Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. (1983) (5)
- Neuropeptide Receptors Are Shared Components of Nervous and Immune Systems (1989) (5)
- Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain (1987) (5)
- The phencyclidine receptor (1983) (5)
- Characterization of interleukin 1 receptors in brain. (1988) (5)
- Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors. (1983) (5)
- Bombesin-like peptides: Neuropeptides with mitogenic activity (1988) (5)
- Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice (2005) (4)
- Peptide T prevents NBM lesion-induced cortical atrophy in aged rats (1996) (4)
- Self-reflective molecular psychology: Aids with a vip key? (1989) (3)
- Syndyphalin SD‐25: A highly selective ligand for μ opiate receptors (1982) FEBS Letters 141,203–206. (1982) (3)
- CORRELATION OF OPIATE RECEPTOR AFFINITY WITH ANALGETIC EFFECTS OF MEPERIDINE HOMOLOGS (1977) (3)
- Conformational malleability of opiate receptors: Sulfhydryl modification alters ion-inducedµ/δ-ligand selectivity shifts in rat striatal sections (1982) (3)
- μ, δ AND κ OPIATE RECEPTORS: INTERCONVERTIBLE FORMS OF THE SAME RECEPTOR (1981) (3)
- Candace Pert, PhD: neuropeptides, AIDS, and the science of mind-body healing. Interview by Bonnie Horrigan. (1995) (3)
- Autoradiographic localization of the phencyclidine/sigma "opiate" receptor in rat brain. (1982) (3)
- Peptide T[4-8]: a pentapeptide sequence in the AIDS virus envelope which blocks infectivity is essentially conserved across nine isolates. (1986) (2)
- Is the benzodiazepine receptor coupled to a chloride anion channel? (reply) (1979) (2)
- Visualization of human helper T lymphocyte differentiation antigen in primate brain (1988) (2)
- Type 1 and type 2 opiate receptor distribution in brain--what does it tell us? (1981) (2)
- NEUROPSYCHOLOGIC RESULTS OF CONTROL HIV‐1 TRIAL OF PEPTIDE T (1992) (2)
- On the Nature of Models: Let Us Now Praise Famous Men and Women, Too (1999) (1)
- Peptide T and the HIV attachment protein gp120 as ligands for a VIP receptor: Biochemical, cellular, and neuroanatomical evidence (1989) (1)
- Isolation and identification of a peptide from rat brain which inhibits [3H]TCP binding. (1990) (1)
- Candace Pert: paradigms from neuroscience: when shift happens. (2003) (1)
- The Emergence of Subtle Organicism (2011) (1)
- P1-359 DAPTA targets CCR5 chemokine receptors and suppresses microglial activation in a neuroinflammatory rat model of Alzheimer's disease (2004) (1)
- Opiate receptor dynamics (1975) (1)
- Modulation of phencyclidine receptor sensitivity. (1983) (1)
- Molecular components common to the immune system and neurons: growth factors and their receptors. (1988) (1)
- Coordinate control of corticotropin, beta-lipotropin, and beta-endorphin release in mouse pituitary cell cultures. (1978) (1)
- distribution Substance P receptors in rat spleen: characterization and autoradiographic (2011) (0)
- Candace Pert: a molecular Jungian in search of the quantum experiment. Interview by Sheldon Lewis. (2002) (0)
- Summary of basic research (1979) (0)
- NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE IX CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974 (1975) (0)
- Foreword to the First Edition (2016) (0)
- How do you understand the connection between memory and emotion ? (2012) (0)
- Opiate receptor: autoradiographic localization in rat brain C.B. Pert, M.J. Kuhar and S.H. Snyder, Proc. nat. Acad. Sci. (Wash.), 73 (1976) 3729–3733 (1977) (0)
- Aids research a leading edge at nimh (1987) (0)
- Amantadine modulates phencyclidine binding site sensitivity in rat brain (1982) (0)
- Effect of beta-FNA on opiate delta receptor binding. (1984) (0)
- HOMOLOGOUS N-ALKYLNORKETOBEMIDONES, CORRELATION OF RECEPTOR BINDING WITH ANALGESIC POTENCY (1975) (0)
- Vasoactive intestinal polypeptide : Specific binding to rat brain membranes ( receptor binding / neuropeptide / neuropharmacology (1999) (0)
- SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF (.+-.)-5,9α-DIMETHYL-2-(2-(4-FLUOROPHENYL)ETHYL)-2′-HYDROXY-6,7-BENZOMORP# HAN (FLUOROPHEN), A LIGAND SUITABLE FOR VISUALIZATION OF OPIATE RECEPTORS IN VIVO (1984) (0)
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