Cyrus Levinthal
American molecular biologist
Cyrus Levinthal's AcademicInfluence.com Rankings
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Biology Physics
Cyrus Levinthal's Degrees
- PhD Biophysics California Institute of Technology
- Bachelors Chemistry University of California, Berkeley
Why Is Cyrus Levinthal Influential?
(Suggest an Edit or Addition)Levinthal graduated with a Ph.D. in physics from University of California, Berkeley and taught physics at the University of Michigan before moving to the Massachusetts Institute of Technology (MIT) in 1957. In 1968 he joined Columbia University as the Chairman and from 1969 Professor of the newly established Department of Biological Sciences, where he remained until his death from lung cancer in 1990.
While at MIT Levinthal made significant discoveries in molecular genetics relating to the mechanisms of DNA replication, the relationship between genes and proteins, and the nature of messenger RNA. At Columbia Levinthal applied computers to the 3-dimensional imaging of biological structures such as proteins. He is considered the father of computer graphical display of protein structure.
According to Wikipedia, Cyrus Levinthal was an American molecular biologist. Biography Levinthal graduated with a Ph.D. in physics from University of California, Berkeley and taught physics at the University of Michigan for seven years before moving to the Massachusetts Institute of Technology in 1957. In 1968 he joined Columbia University as the Chairman and from 1969 Professor of the newly established Department of Biological Sciences, where he remained until his death from lung cancer in 1990.
Cyrus Levinthal's Published Works
Published Works
- Are there pathways for protein folding (1968) (1351)
- A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. I. Purification and characterization of alkaline phosphatase. (1960) (1158)
- Analysis of C14-labeled proteins by disc electrophoresis. (1965) (415)
- How to fold graciously (1969) (407)
- Molecular model-building by computer. (1966) (262)
- Predicting antibody hypervariable loop conformation. I. Ensembles of random conformations for ringlike structures (1987) (247)
- Three Dimensional Reconstruction from Serial Sections (1972) (225)
- Messenger RNA turnover and protein synthesis in B. subtilis inhibited by actinomycin D. (1962) (212)
- Structure and development of neuronal connections in isogenic organisms: cellular interactions in the development of the optic lamina of Daphnia. (1973) (211)
- Predicting antibody hypervariable loop conformations II: Minimization and molecular dynamics studies of MCPC603 from many randomly generated loop conformations (1986) (199)
- Structure and development of neuronal connections in isogenic organisms: variations and similarities in the optic system of Daphnia magna. (1973) (192)
- Reactivation and hybridization of reduced alkaline phosphatase. (1962) (184)
- Alkaline phosphatase of Escherichia coli: a zinc metalloenzyme. (1962) (179)
- Colicin E1 binding to membranes: time-resolved studies of spin-labeled mutants (1993) (147)
- Protein synthesis by Escherichia coli infected with bacteriophage T4D. (1968) (146)
- Degradation of deoxyribonucleic acid under hydrodynamic shearing forces. (1961) (137)
- Three-dimensional computer reconstruction of neurons and neuronal assemblies. (1979) (132)
- Hybrid protein formation of E. coli alkaline phosphatase leading to in vitro complementation. (1963) (129)
- Site‐directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation (1989) (123)
- Synthesis and maturation of ribosomal RNA in Escherichia coli. (1969) (122)
- Structure and development of neuronal connections in isogenic organisms: transient gap junctions between growing optic axons and lamina neuroblasts. (1974) (104)
- A purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene (1988) (98)
- ON THE UNWINDING OF DNA. (1956) (90)
- MESSENGER RNA DECAY AND PROTECTION. (1964) (84)
- Growing optic nerve fibers follow neighbors during embryogenesis. (1980) (83)
- Measurement of the unstable RNA in exponentially growing cultures of Bacillus subtilis and Escherichia coli. (1968) (82)
- Recombination in Phage T2: Its Relationship to Heterozygosis and Growth. (1954) (76)
- Structure-function relationships for a voltage-dependent ion channel: properties of COOH-terminal fragments of colicin E1. (1983) (76)
- THE MECHANISM OF DNA REPLICATION AND GENETIC RECOMBINATION IN PHAGE. (1956) (74)
- The Decay and Protection of Messenger RNA in Bacteria (1963) (70)
- Hemoglobin interaction in sickle cell fibers. I: Theoretical approaches to the molecular contacts. (1975) (69)
- Interactive computer graphics and representation of complex biological structures. (1972) (60)
- Visual cells of zebrafish optic tectum: Mapping with small spots (1982) (59)
- The structural unity of the DNA of T2 bacteriophage. (1961) (57)
- RNA metabolism in T4-infected Escherichia coli. (1970) (57)
- Anatomy and development of identified cells in isogenic organisms. (1976) (56)
- A very short peptide makes a voltage‐dependent ion channel: The critical length of the channel domain of colicin E1 (1986) (53)
- Special techniques for the automatic computer reconstruction of neuronal structures. (1980) (51)
- Messenger RNA and RNA transcription time. (1967) (50)
- Molecular autoradiography: the beta-ray counting from single virus particles and DNA molecules in nuclear emulsions. (1957) (49)
- The Control of Protein Synthesis after Phage Infection (1967) (45)
- FASTRUN: A special purpose, hardwired computer for molecular simulation (1991) (45)
- The production of incomplete bacteriophage particles by the action of proflavine and the properties of the incomplete particles. (1953) (43)
- Growth and Recombination in Bacterial Viruses. (1953) (41)
- The structural development of a bacterial virus. (1952) (40)
- Effects of lambda-phage infection on bacterial synthesis. (1967) (37)
- Ordered Synthesis of Proteins During Outgrowth of Spores of Bacillus cereus (1967) (37)
- Conformational flexibility and protein folding: rigid structural fragments connected by flexible joints in subtilisin BPN. (1976) (36)
- Isolation and characterization of complementation products of Escherichia coli alkaline phosphatase. (1966) (35)
- Computer-aided reconstruction from serial sections. (1974) (34)
- Inhibitory mechanism in zebrafish optic tectum: Visual response properties of tectal cells altered by picrotoxin and bicuculline (1983) (32)
- Gene expression in intergeneric merozygotes. (1961) (32)
- A vectorized algorithm for calculating the accessible surface area of macromolecules (1991) (32)
- Visual response properties of zebrafish tectal cells (1982) (31)
- The Synthesis and Degradation of Lactose Operon Messenger RNA in E. coli (1970) (29)
- Model-building of neurohypophyseal hormones. (1973) (24)
- A single tryptic fragment of colicin E1 can form an ion channel: Stoichiometry confirms kinetics (1991) (20)
- Maturation of phage and the evidence of phage precursors. (1953) (17)
- In Vitro Formation of Enzymatically Active Hybrid Proteins from E. Coli Alkaline Phosphatase CRM's (1963) (17)
- Coding Aspects of Protein Synthesis (1959) (17)
- Exclusion of RNA bacteriophages and interference with their RNA replication by bacteriophage T4. (1967) (17)
- CARTOS II semi-automated nerve tracing: three-dimensional reconstruction from serial section micrographs. (1990) (12)
- A purkinje cell differentiation marker shows a partial dna sequence homology to the cellular sis/pdgf2 gene. (1989) (11)
- A graph theory model of the glomerular capillary network and its development. (1984) (11)
- Genetic and chemical studies with alkaline phosphatase of E. coli. (1959) (11)
- Comment: “Dry” enzymes (1986) (10)
- PRODUCTION OF PROTONS BY HIGH ENERGY $gamma$ RAYS (1951) (10)
- Complementation at the molecular level of enzyme interaction. (1965) (9)
- Alterations in alkaline phosphatase induced by mutations (1961) (9)
- Electrophoresis: an accident and some precautions. (1966) (9)
- Anomalous anatomy of identified neurons in the larval prawn: spontaneous and induced by microlesions (1982) (8)
- Hybrid Protein Formation of E. coli Alkaline Phosphatase Leading to in vitro Complementation (1989) (8)
- Recombination in phage: its relationship to heterozygosis and growth. (1953) (7)
- DEVELOPMENT OF PHAGE T2 DESOXYRIBOSENUCLEIC ACID IN THE ABSENCE OF NET PROTEIN SYNTHESIS (1955) (7)
- Chapter VIII – Bacteriophage Genetics (1959) (7)
- Inelastic Scattering of Protons by Aluminum and Carbon (1950) (6)
- Hydrohynamic shear stress and the tensile strength of covalent bonds (1967) (5)
- The Formation of Three‐Dimensional Biological Structures (1984) (5)
- Hemoglobin Interaction in Sickle Cell Fibers (4)
- Neural Development in Isogenic Organisms—A Summary Report (1974) (3)
- Symposium overview Minnesota Conference on Supercomputing in Biology: Proteins, Nucleic Acids, and Water (1988) (3)
- Shear degradation and the molecular weight of DNA (1961) (3)
- On the pathways of neural development. (1983) (2)
- REPRESENTATION OF COMPLEX BIOLOGICAL STRUCTURES (1972) (2)
- New Methods of Pattern Recognition for Three-Dimensional Reconstruction and Display of Nerves and Molecules (1986) (1)
- A Moral Duty (1968) (1)
- Genetics and the Role of Nucleic Acids (1959) (1)
- Computer Graphics in Molecular Biology (1971) (1)
- FASTRUN- A HIGHPERFORMANCE COMPUTINGDEVICEFORMOLECULARMECHANICSUSINGA PIPELINEARCHITECTURE* (1986) (0)
- Molecular mechanics work station for protein conformational studies (1984) (0)
- Structure and Development of Neuronal Connections in Isogenic Organisms : Cellular Interactions in the Development of the Optic Lamina of Daphnia * ( neuronal specificity / serial section reconstruction / crustacea ) (0)
- "Dry" enzymes. (1986) (0)
- Editorial (1986) (0)
- Letter from Cy Levinthal to Francis Crick (1957) (0)
- Letter from Cy Levinthal to Joshua Lederberg (1953) (0)
- PHOTO-EJECTION OF PROTONS (1950) (0)
- Crimes and Science Fellowships (1961) (0)
- Evidence for the maintenance of the physical integrity of the chromosome of phage (1956) (0)
- FASTRUN - A High Performance Computing Device for Molecular Mechanics Using a Pipeline Architecture (1985) (0)
- Computer applications in cellular research: three-dimensional brain reconstructions (1971) (0)
- Modelling the structure of highly constrained proteins. (1989) (0)
- Crimes, Science Fellowships, and the Disclaimer Affidavit. (1962) (0)
- Crimes and Science Fellowships. (1961) (0)
- A Study of Protons Ejected from Nuclei by High Energy Gamma Rays (1950) (0)
- FASTRUN—a special purpose hard-wired computing device for molecular mechanics (1990) (0)
- Editorial (1986) (0)
- Microbial geneticsEdited by W. Hayes and R. C. Clowes. The Tenth Symposium of the Society for General Microbiology held at the Royal Institution, London, 1960. University Press, Cambridge, 1960. xii + 300 pp. illus. Price $7.50 (1961) (0)
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