Daisuke Koya
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Engineering Biology
Daisuke Koya's Degrees
- PhD Biomedical Engineering University of Tokyo
- Masters Biotechnology Kyoto University
- Bachelors Chemistry Osaka University
Why Is Daisuke Koya Influential?
(Suggest an Edit or Addition)Daisuke Koya's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Protein kinase C activation and the development of diabetic complications. (1998) (1362)
- Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor (1996) (1029)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. (1997) (557)
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. (2010) (526)
- Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes (2000) (449)
- Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. (1997) (418)
- Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. (1996) (382)
- SIRT1 and insulin resistance (2009) (348)
- Progression of diabetic nephropathy. (2003) (347)
- Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway (2011) (307)
- Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus (1997) (291)
- Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen (2014) (290)
- Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. (2003) (283)
- Emerging role of autophagy in kidney function, diseases and aging (2012) (226)
- Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. (2007) (222)
- Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. (1997) (221)
- SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation* (2007) (220)
- Structural and functional changes in the kidneys of high-fat diet-induced obese mice. (2009) (220)
- Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy (2015) (219)
- Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. (2005) (206)
- SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential (2013) (201)
- Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. (2003) (197)
- Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes. (2005) (195)
- Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis (2013) (194)
- Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes (2011) (192)
- Sirtuins and renal diseases: relationship with aging and diabetic nephropathy (2012) (186)
- Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. (2013) (185)
- The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis (2016) (179)
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. (2006) (175)
- Biology of Obesity: Lessons from Animal Models of Obesity (2011) (170)
- Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet. (2010) (170)
- Rodent models of diabetic nephropathy: their utility and limitations (2016) (165)
- A new classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy (2015) (158)
- Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes (2007) (155)
- Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. (2000) (152)
- Renal Protective Effects of Resveratrol (2013) (149)
- Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease (2013) (141)
- Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis. (2011) (140)
- Nutrient Sensing, Autophagy, and Diabetic Nephropathy (2011) (136)
- Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function (2019) (130)
- Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension (2006) (128)
- Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition. (2015) (127)
- SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells. (2011) (125)
- Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. (2006) (124)
- Glucocorticoid-Induced Diabetes Mellitus: Prevalence and Risk Factors in Primary Renal Diseases (2006) (122)
- Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model. (2009) (119)
- Involvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells. (2003) (119)
- Peroxisome proliferator-activated receptor-γ ligands inhibit TGF-β1-induced fibronectin expression in glomerular mesangial cells (2004) (119)
- Overview of glucose signaling in mesangial cells in diabetic nephropathy. (2003) (110)
- A new Classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy (2014) (106)
- Acupuncture: is it effective for treatment of insulin resistance? (2009) (104)
- Autophagy in metabolic disease and ageing (2021) (103)
- Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes. (2014) (103)
- Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation. (1991) (102)
- MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT (2013) (101)
- Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes. (2009) (99)
- Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules. (2020) (98)
- Autophagy as a Therapeutic Target in Diabetic Nephropathy (2011) (97)
- TGF-beta 1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells. (1999) (96)
- SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis (2018) (87)
- Asialoerythropoietin prevents contrast-induced nephropathy. (2008) (86)
- Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high‐fat diet (2018) (80)
- Predictive Effects of Urinary Liver-Type Fatty Acid–Binding Protein for Deteriorating Renal Function and Incidence of Cardiovascular Disease in Type 2 Diabetic Patients Without Advanced Nephropathy (2013) (80)
- Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells (2007) (77)
- Sirtuins as possible drug targets in type 2 diabetes. (2013) (77)
- The impact of dietary protein intake on longevity and metabolic health (2019) (75)
- Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C. (1997) (74)
- Estrogen and raloxifene, a selective estrogen receptor modulator, ameliorate renal damage in db/db mice. (2005) (74)
- N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells. (2003) (74)
- Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus (2005) (72)
- Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study (2007) (71)
- Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell. (2010) (71)
- Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway. (2001) (71)
- Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function. (2015) (70)
- Dietary restriction: standing up for sirtuins. (2010) (70)
- Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells. (2001) (70)
- MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells. (2005) (69)
- Enhancement of glomerular heme oxygenase-1 expression in diabetic rats. (2001) (69)
- Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial (2009) (69)
- AST-120 (Kremezin) initiated in early stage chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects. (2008) (68)
- A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity (2016) (68)
- Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy (2015) (68)
- Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. (1995) (66)
- The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy (2013) (66)
- N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition (2014) (66)
- Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase. (1999) (66)
- Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. (2018) (65)
- Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy (2017) (64)
- Association Between Urinary Type IV Collagen Level and Deterioration of Renal Function in Type 2 Diabetic Patients Without Overt Proteinuria (2010) (64)
- d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. (1999) (64)
- Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. (2013) (64)
- Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways. (2013) (62)
- N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice. (2005) (61)
- Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions (1994) (61)
- Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes (2011) (60)
- N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis. (2006) (60)
- Autophagy: emerging therapeutic target for diabetic nephropathy. (2014) (59)
- Abnormalities in protein kinase C and MAP kinase cascade in mesangial cells cultured under high glucose conditions. (1995) (59)
- Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1α in Skeletal Muscle (2010) (57)
- Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides. (1996) (57)
- Dipeptidyl peptidase-4 and kidney fibrosis in diabetes (2016) (56)
- Protein Kinase Cβ Selective Inhibitor LY333531 Attenuates Diabetic Hyperalgesia Through Ameliorating cGMP Level of Dorsal Root Ganglion Neurons (2003) (55)
- Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy. (2001) (55)
- Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy (2013) (55)
- PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity (2017) (55)
- Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy (2014) (54)
- Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus. (2010) (54)
- 15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β–induced cyclooxygenase-2 expression in mesangial cells (2002) (54)
- Role of mitogen-activated protein kinases as downstream effectors of transforming growth factor-β in mesangial cells (2000) (53)
- Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells (1991) (53)
- Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis (2020) (51)
- APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study. (2003) (51)
- Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial (2015) (50)
- Lipid mediators in diabetic nephropathy (2014) (50)
- Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis (2016) (50)
- Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. (2013) (49)
- Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes. (1999) (49)
- Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes. (2011) (48)
- Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells. (2004) (48)
- SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells. (2012) (46)
- Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs (2020) (46)
- SirT 1 and insulin resistance (2009) (46)
- Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation (2016) (45)
- FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway (2017) (45)
- SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. (2010) (45)
- Combinational effect of genes for the renin–angiotensin system in conferring susceptibility to diabetic nephropathy (2006) (45)
- d‐α‐tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C‐diacylglycerol pathway (1998) (44)
- Diabetic angiopathy and angiogenic defects (2012) (44)
- Clinical therapeutic strategies for early stage of diabetic kidney disease. (2014) (41)
- Cerebral microvascular disease predicts renal failure in type 2 diabetes. (2010) (41)
- The Japanese clinical practice guideline for acute kidney injury 2016 (2018) (41)
- Predictive Properties of Plasma Amino Acid Profile for Cardiovascular Disease in Patients with Type 2 Diabetes (2014) (40)
- Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats (2018) (40)
- Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance. (2017) (40)
- CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats (2020) (39)
- Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus (2011) (39)
- Successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report (2004) (39)
- Linagliptin but not Sitagliptin inhibited transforming growth factor-β2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition. (2016) (38)
- GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice (2011) (38)
- Endothelial FGFR1 (Fibroblast Growth Factor Receptor 1) Deficiency Contributes Differential Fibrogenic Effects in Kidney and Heart of Diabetic Mice (2020) (37)
- Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats. (2000) (37)
- Pathophysiology of the aging kidney and therapeutic interventions (2012) (37)
- The biological consequence of obesity on the kidney. (2013) (36)
- Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. (2003) (35)
- Role of dietary amino acid balance in diet restriction‐mediated lifespan extension, renoprotection, and muscle weakness in aged mice (2018) (35)
- Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen (2016) (35)
- Metabolic reprogramming by N‐acetyl‐seryl‐aspartyl‐lysyl‐proline protects against diabetic kidney disease (2020) (34)
- High blood pressure is a risk factor for the development of microalbuminuria in Japanese subjects with non-insulin-dependent diabetes mellitus. (1992) (34)
- Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways (2020) (33)
- Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease (2020) (33)
- 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells. (2015) (33)
- Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker (2009) (33)
- Biological receptors mediate anti-proliferative action of atrial natriuretic peptide in cultured mesangial cells. (1993) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells (2021) (33)
- Alteration of mesangial response to ANP and angiotensin II by glucose. (1993) (33)
- Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice (2017) (31)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. (2012) (31)
- Pulmonary-renal syndrome, diffuse pulmonary hemorrhage and glomerulonephritis, associated with Wegener's granulomatosis effectively treated with early plasma exchange therapy. (2007) (30)
- Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus. (2008) (30)
- The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans (2017) (30)
- Role of sirtuins in kidney disease (2014) (29)
- Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress (2021) (29)
- The Japanese Clinical Practice Guideline for acute kidney injury 2016 (2018) (29)
- Cancer biology in diabetes (2014) (29)
- The PKM2 activator TEPP‐46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF‐1α accumulation (2020) (28)
- Fructose induces tubulointerstitial injury in the kidney of mice. (2012) (27)
- Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II (2017) (27)
- Role of mitogen-activated protein kinases as downstream effectors of transforming growth factor-beta in mesangial cells. (2000) (27)
- Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys (2020) (27)
- Antagonist for atrial natriuretic peptide receptors ameliorates glomerular hyperfiltration in diabetic rats. (1993) (27)
- Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014 (2019) (27)
- Overexpression of core 2 N‐acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice (1999) (27)
- The Relevance of the Renin-Angiotensin System in the Development of Drugs to Combat Preeclampsia (2015) (27)
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version (2013) (27)
- A Low-Protein Diet for Diabetic Kidney Disease: Its Effect and Molecular Mechanism, an Approach from Animal Studies (2018) (26)
- Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules. (2013) (26)
- Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors (2011) (26)
- Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis (2021) (25)
- N-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes (2014) (24)
- Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells. (1995) (24)
- N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators. (2006) (24)
- Low-Protein Diet for Diabetic Nephropathy (2014) (24)
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version (2013) (24)
- MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells. (2016) (23)
- Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. (2013) (23)
- Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria. (2006) (23)
- Renoprotective effects of asialoerythropoietin in diabetic mice against ischaemia–reperfusion‐induced acute kidney injury (2010) (22)
- Conditions, pathogenesis, and progression of diabetic kidney disease and early decliner in Japan (2020) (22)
- Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling (2020) (21)
- Translocation of protein kinase C alpha and zeta in rat glomerular mesangial cells cultured under high glucose conditions. (1994) (21)
- AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications (2018) (21)
- Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma (2015) (21)
- A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity (2018) (21)
- Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice (2019) (21)
- Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. (2003) (20)
- Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria. (2011) (20)
- Autophagy: a novel therapeutic target for kidney diseases (2012) (20)
- 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. (2002) (20)
- Reduced activity of renal angiotensin-converting enzyme in streptozotocin-induced diabetic rats. (1991) (19)
- Supplement of Tetrahydrobiopterin by a Gene Transfer of GTP Cyclohydrolase I cDNA Improves Vascular Dysfunction in Insulin-Resistant Rats (2005) (18)
- Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 5 (2019) (18)
- Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021) (18)
- Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure. (2015) (17)
- Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes (2020) (17)
- Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity (2020) (17)
- Design and methods of a strategic outcome study for chronic kidney disease: Frontier of Renal Outcome Modifications in Japan (2010) (17)
- CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology (2021) (17)
- Statin use in patients with diabetes and kidney disease: the Japanese experience. (2013) (16)
- [Classification of Diabetic Nephropathy 2014]. (2014) (16)
- C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus. (2003) (16)
- Microalbuminuria associated with a rise in blood pressure in non-insulin-dependent diabetes. (1989) (15)
- Sirtuins and Renal Oxidative Stress (2021) (15)
- Therapeutic management of diabetic kidney disease (2011) (15)
- Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy (2009) (15)
- Systemic cholesterol embolization syndrome associated with myeloperoxidase-anti-neutrophil cytoplasmic antibody. (2006) (15)
- Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance Through the CXCL12/CXCR4/mTOR/TGFβ Signaling Pathway in Breast Cancer Cells (2020) (15)
- Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine (2020) (14)
- Role of Sirt1 as a Regulator of Autophagy (2016) (14)
- Dipeptidyl peptidase-4 inhibition and renoprotection: the role of antifibrotic effects (2017) (14)
- The biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis (2015) (14)
- Correlation Between Albuminuria and Spontaneous Platelet Microaggregate Formation in Type 2 Diabetic Patients (2009) (14)
- Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease (2021) (13)
- Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol (2011) (13)
- Efficacy and tolerability of vildagliptin in type 2 diabetic patients on hemodialysis (2011) (13)
- The administration of pitavastatin augments creatinine clearance associated with reduction in oxidative stress parameters: acute and early effects (2013) (13)
- Randomized trial of an intensified, multifactorial intervention in patients with advanced‐stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) (2020) (12)
- A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus. (2018) (12)
- Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia. (2009) (12)
- Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial (2016) (12)
- Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS (2018) (11)
- Effects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: Rationale and design of the ASsessment of clinical Usefulness in CKD patients with Atorvastatin (ASUCA) trial (2013) (11)
- The use of calorie restriction mimetics to study aging. (2013) (11)
- Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity (2020) (11)
- Carotid atherosclerosis mediated by visceral adiposity and adipocytokines in type 2 diabetic subjects. (2009) (11)
- Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes. (2016) (11)
- Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan): Rationale and study design. (2010) (11)
- The impact of mitochondrial quality control by Sirtuins on the treatment of type 2 diabetes and diabetic kidney disease. (2020) (11)
- Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose. (2011) (11)
- Significance of SGLT2 inhibitors: lessons from renal clinical outcomes in patients with type 2 diabetes and basic researches (2020) (10)
- Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon (2019) (10)
- FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p. (2018) (10)
- Effects of SGLT2 Inhibitors on Atherosclerosis: Lessons from Cardiovascular Clinical Outcomes in Type 2 Diabetic Patients and Basic Researches (2021) (10)
- Diabetic nephropathy (2017) (10)
- Metabolic actions of insulin-like growth factor I in cultured glomerular mesangial cells. (1991) (10)
- The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria. (2012) (10)
- Nipradilol inhibits rat mesangial cell mitogenesis through the activation of soluble guanylate cyclase. (1993) (9)
- Effect of switching to teneligliptin from other dipeptidyl peptidase‐4 inhibitors on glucose control and renoprotection in type 2 diabetes patients with diabetic kidney disease (2018) (9)
- Animal Models of Diabetes and Its Associated Complications (2013) (8)
- Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner (2017) (8)
- Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy (2014) (8)
- Evaluation of a new care system provided to diabetic patients in the outpatient clinic. (2000) (8)
- Microalbuminuria cannot predict cardiovascular death in Japanese subjects with non-insulin-dependent diabetes mellitus. (1995) (8)
- NAD+ Homeostasis in Diabetic Kidney Disease (2021) (8)
- Dual protein kinase C alpha and beta inhibitors and diabetic kidney disease: a revisited therapeutic target for future clinical trials (2013) (8)
- Glucose-induced overproduction of type IV collagen in cultured glomerular mesangial cells. (1991) (8)
- Protein Kinase C Selective Inhibitor LY 333531 Attenuates Diabetic Hyperalgesia Through Ameliorating cGMP Level of Dorsal Root Ganglion Neurons (2003) (8)
- Japan Diabetic Nephropathy Cohort Study: study design, methods, and implementation (2013) (7)
- Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes (2016) (7)
- A case of myeloperoxidase–antineutrophil cytoplasmic antibody positive-polyarteritis nodosa complicated by interstitial pneumonia and rapidly progressive renal failure (2007) (6)
- Three ileus cases associated with the use of dipeptidyl peptidase‐4 inhibitors in diabetic patients (2013) (6)
- A lack of increase in high molecular weight-adiponectin in macroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks. (2008) (6)
- βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (2019) (6)
- Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans (2020) (6)
- Effect of protein kinase C&bgr; inhibitor on Ca2+ homeostasis in diabetic sensory neurons (2006) (6)
- Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats (2021) (6)
- Cyclic and intermittent very low‐protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity (2017) (6)
- Sodium–glucose cotransporter 2 inhibitors in type 2 diabetes patients with renal function impairment slow the annual renal function decline, in a real clinical practice (2021) (5)
- Cyclic nucleotides attenuate endothelin-1-induced activation of mitogen-activated protein kinase in cultured rat mesangial cells. (1995) (5)
- The Japanese Clinical Practice Guideline for acute kidney injury 2016 (2018) (5)
- Medical nutrition therapy and dietary counseling for patients with diabetes-energy, carbohydrates, protein intake and dietary counseling (2020) (5)
- Differential modulation of mitogenic and metabolic actions of insulin-like growth factor I in rat glomerular mesangial cells in high glucose culture (1993) (5)
- Mesangial cell dysfunction as a pathogenesis of diabetic nephropathy. (2001) (5)
- Lupus vasculopathy combined with renal infarction: unusual manifestation of lupus nephritis. (2005) (4)
- Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells. (2002) (4)
- [Diagnosis and management of diabetic nephropathy]. (2015) (4)
- Levofloxacin-induced Achilles tendon rupture in a patient with systemic microscopic polyangiitis (2005) (4)
- N-Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR ≥ 30 ml/min/1.73 m2 (2019) (4)
- Cilostazol Attenuates Spontaneous Microaggregation of Platelets in Type 2 Diabetic Patients With Insufficient Platelet Response to Aspirin (2013) (4)
- Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells. (1991) (3)
- Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity (2021) (3)
- CD‐1db/db mice: A novel type 2 diabetic mouse model with progressive kidney fibrosis (2020) (3)
- Managing Diabetic Nephropathies in Clinical Practice (2016) (3)
- Epidermal growth factor receptor signaling and the progression of diabetic nephropathy (2015) (3)
- Protein Kinase C in Diabetic Renal Involvement, the Perspective of its Inhibition (2000) (3)
- Miscellaneous dermatoses. (1978) (3)
- Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium–glucose cotransporter 2 inhibitor administration (2020) (3)
- Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy (2013) (3)
- Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR) (2021) (3)
- A case of acute renal failure complicated with Takotsubo cardiomyopathy (2004) (2)
- Diabetic kidney disease: Its current trends and future therapeutic perspectives (2019) (2)
- [Kidney disease and insulin resistance--clinical impact of thiazolidinedione compounds for kidney disease]. (2000) (2)
- Impact of empagliflozin on diabetic kidney disease (2017) (2)
- Anterior pituitary function in Rathke's cleft cysts versus nonfunctioning pituitary adenomas. (2021) (2)
- [Case of autosomal dominant polycystic kidney disease associated with congenital hepatic fibrosis]. (2005) (1)
- Interaction between atrial natriuretic peptide and angiotensin II in cultured glomerular mesangial cells and its disturbance in diabetes. (1994) (1)
- Efficacy of SGLT2 inhibitor in type 2 diabetic patients under dietary instructions: A pilot study (2020) (1)
- Rapid enlargement of an intracranial germ cell tumor after gonadotropin hormone therapy (2016) (1)
- [Sirt1-mediated autophagy in aging kidney]. (2012) (1)
- PDB16 - COMPARE RENAL FUNCTIONAL PRSERVATION OUTCOME OF SGLT2 INHIBITOR VS DPP4 INHIBITOR IN PATIENTS WITH TYPE 2 DIABETES: A RETROSPECTIVE COHORT STUDY OF JAPANESE COMMERCIAL DATABASE WITH ADVANCED ANALYTICS APPROACH (2018) (1)
- Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity. (2022) (1)
- Infective endocarditis. (2002) (1)
- [Diabetic nephropathy--progress in its preclinical and clinical studies]. (2003) (1)
- E¡ect of protein kinase Cb inhibitor on Ca homeostasis in diabetic sensory neurons (2006) (1)
- Adenosine/adenosine type 1 receptor signaling pathway did not play dominant roles on the influence of sodium–glucose cotransporter 2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice (2022) (1)
- Corrigendum to “Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells” [FEBS Lett. 581 (2007) 1417–1424] (2007) (1)
- [Molecular understanding of adverse effects of hyperglycemia in diabetic nephropathy]. (2007) (1)
- [The cutting-edge of medicine; new therapeutic targets for renal senescence]. (2013) (0)
- Severe electrolytes disorders with the interstitial kidney alterations in the patient with the history of total thyroidectomy and parathyroidectomy: possible role of vitamin D deficiency (2018) (0)
- [Diabetic nephropathy]. (2005) (0)
- Backcross db Gene into CD-1 Background Results in Novel Type 2 Diabetic Mouse Model with Progressive Kidney Fibrosis (2018) (0)
- WCN23-0618 CARDIORENAL OUTCOMES WITH FINERENONE IN ASIAN PATIENTS WITH CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETES: PRESPECIFIED SUB-ANALYSIS FROM FIDELITY (2023) (0)
- [A case of pulmonary sarcoidosis associated with severe hypercalcemia]. (1994) (0)
- [Epidemiology of diabetic nephropathy]. (2012) (0)
- Mesangial cell dysfunction. (1991) (0)
- [Chronic kidney disease (CKD)--recent progress. Topics: VI. Chronic kidney disease (CKD) and associated disorders; 2. Diabetes]. (2012) (0)
- Rapid communication Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells (1991) (0)
- [The effect of PKC inhibitor on diabetic vascular complications]. (2010) (0)
- [Sirt1 in diabetic nephropathy]. (2011) (0)
- ACUTE NEPHRITIC SYNDROME AND POLYMYALGIA RHEUMATICA: COINCIDENTAL OR ASSOCIATED? (2007) (0)
- [Protein kinase C pathway]. (2016) (0)
- 90. Catechol-O-methyltransferase deficiency leads to hypersensitivity on the pressor response against angiotensin II (2018) (0)
- [PP.05.07] COMPARATIVE EFFECTS OF DIRECT RENIN INHIBITOR AND ANGIOTENSIN RECEPTOR BLOCKER ON ALBUMINURIA IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES (2016) (0)
- Targeted overexpression of protein kinase C (cid:98) 2 isoform in myocardium causes cardiomyopathy (1997) (0)
- Rationale, design and baseline characteristics of the effect of canagliflozin in patients with type 2 diabetes and microalbuminuria in the Japanese population: The CANPIONE study (2022) (0)
- Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia (2016) (0)
- Diabetic nephropathy: advances in treatment. (2017) (0)
- [New therapeutic strategy for diabetic nephropathy--remission and regression]. (2010) (0)
- Acknowledgment to reviewers 2013 (2014) (0)
- Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report (2022) (0)
- SAT-299 CD38 INHIBITION DECREASE RENAL OXIDATIVE STRESS IN DIABETIC KIDNEY DISEASE BY RESTORING OF SIRT3 ACTIVATION. (2019) (0)
- 513-P: Adenosine Signal Plays an Important Role in Renoprotective Effects of SGLT2 Inhibitor in Proteinuric Diabetic Mice (2019) (0)
- Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity (2020) (0)
- Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice (2019) (0)
- [Progress on the drug therapy for diabetic microangiopathies: PKCbeta inhibitor]. (2005) (0)
- Patient Assessment and Diagnosis (2017) (0)
- [Management of blood glucose in diabetic patients undergoing dialysis therapy]. (2004) (0)
- Activated platelet profile and albuminuria Correlation between albuminuria and spontaneous platelet micro-aggregate formation in type 2 diabetic patients Running title: Activated platelet profile and albuminuria (2009) (0)
- Dietary intake and physical activity in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention prospective study (JDCP study 8) (2022) (0)
- Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis. (2023) (0)
- EFFECTS OF A MICRNUTRIENT SUPPLEMENT (VCRESC eq \o\ac(○,R)) ON VITAMIN AND HOMOCYSTEINE LEVELS IN END STAGE RENAL DISEASE PATIENT: 12 MONTH FOLLOW UP (2012) (0)
- Erratum to: Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker (2009) (0)
- [Food intake-suppressing action of incretin and anti-obesity therapy]. (2011) (0)
- PO151 THE ANTIFIBROTIC MICRORNA CROSSTALK IN THE ACTION OF N-ACETYL-SERYL-ASPARTYL-LYSYL-PROLINE (2014) (0)
- Proposal of classification of “chronic kidney disease (CKD) with diabetes” in clinical setting (2019) (0)
- Rapid effects of pitavastatin on uric acid homeostasis (2011) (0)
- [Lowering blood pressure and glucose reduces renal events in type 2 diabetes; ADVANCE study]. (2010) (0)
- 463-P: Linagliptin Ameliorated Heart Damage Associated with the Suppression of Necroptosis in Type 1 Diabetic Mice (2019) (0)
- The Protective Effect Of A Low-protein Diet Against Tubulo-interstitial Damage In Diabetic Kidneys (2016) (0)
- [108th Scientific Meeting of the Japanese Society of Internal Medicine: educational lecture: 2. Therapeutic strategy for diabetic nephropathy]. (2011) (0)
- FIBROSIS , TUBULAR CELL APOPTOSIS AND SIRT 1 IN THE KIDNEY (2013) (0)
- SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis (2018) (0)
- Nutrient Sensing and Regulation of Cellular Functions; Involvement with Obesity, Metabolic Syndrome and Diabetes (2013) (0)
- O13. Catechol-O-methyltransferase deficiency leads to hypersensitivity on the pressor response against angiotensin II (2015) (0)
- Adenosine/A1R signaling pathway did not play dominant roles on the influence of SGLT2 inhibitor in the kidney of BSA-overloaded STZ-induced diabetic mice. (2022) (0)
- high-fat diet-induced obese mice Structural and functional changes in the kidneys of (2013) (0)
- [Diabetic nephropathy--definition, stages, measurement of albuminuria, and therapy]. (1997) (0)
- Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice (2017) (0)
- The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research (2023) (0)
- 1P-0157 Peroxisome proliferator-activator receptor-γ ligands inhibits TGF-β1-induced fibronectin expression in glomerular mesangial cells (2003) (0)
- Renal Mitochondrial Oxidative Stress Induced by NAD+-Dependent Sirt3 Inactivation via Overexpression of CD38 (NAD+ase) in Diabetic Kidney Disease (2018) (0)
- Insulin-like growth factor I stimulates glucose uptake and expression of glucose transporter 1 in cultured mesangial cells (1999) (0)
- PPAR-γ Ligands and Diabetic Nephropathy (2006) (0)
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What Schools Are Affiliated With Daisuke Koya?
Daisuke Koya is affiliated with the following schools:
