Hamilton O. Smith

Hamilton O. Smith's AcademicInfluence.com Rankings

Hamilton O. Smith

Biology

#165

World Rank

#299

Historical Rank

#101

USA Rank

Microbiology

#163

World Rank

#193

Historical Rank

#62

USA Rank

biology Degrees

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Biology

Hamilton O. Smith's Degrees

PhD Microbiology Johns Hopkins University
Doctorate Medicine Johns Hopkins University

Why Is Hamilton O. Smith Influential?

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Areas of Specialization: Microbiology
Hamilton Smith, M. D., is a microbiologist, distinguished professor and scientific director of Synthetic Biology & Bioenergy at the J. Craig Venter Institute (JCVI) in San Diego, California. He earned a B.A. in mathematics from the University of California, Berkeley in 1952 and a M.D. from Johns Hopkins University in 1956. He interned at Barnes Hospital in St. Louis and completed a Medical Residency at the Henry Ford Hospital in Detroit, Michigan. From 1962 to 1967 he did a fellowship in the Human Genetics department, University of Michigan, Ann Arbor. From 1967 to 1998 he was Professor of Molecular Biology and Genetics, Johns Hopkins University School of Medicine.

He is co-credited with discovering Hindll, the first type II restriction enzyme and his work with DNA methylases and bacterial host restriction. He went on to earn, with Werner Arber and Daniel Nathans, a Nobel Prize in Physiology or Medicine, for their work on type II restriction enzymes.

His later work has focused on genomics. He contributed to the first sequencing of a bacterial genome, and was instrumental in the mapping of the human genome. While working with the J. Craig Venter Institute, he has worked on the creation of partially synthetic life.

Most recently, Smith has been focusing on better understanding the genetic requirements for minimal bacterial life, as well as the mechanism of DNA cassette insertional mutagenesis in yeast.

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According to Wikipedia, Hamilton Othanel Smith is an American microbiologist and Nobel laureate. Smith graduated from University Laboratory High School of Urbana, Illinois. He attended the University of Illinois at Urbana-Champaign, but in 1950 transferred to the University of California, Berkeley, where he earned his B.A. in Mathematics in 1952 . He received his medical degree from Johns Hopkins School of Medicine in 1956. Between 1956 and 1957 Smith worked for the Washington University in St. Louis Medical Service. In 1975, he was awarded a Guggenheim Fellowship he spent at the University of Zurich.

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Hamilton O. Smith's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Enzymatic assembly of DNA molecules up to several hundred kilobases (2009) (7337)
The Sequence of the Human Genome (2001) (6572)
The genome sequence of Drosophila melanogaster. (2000) (6125)
Environmental Genome Shotgun Sequencing of the Sargasso Sea (2004) (4253)
The complete genome sequence of the gastric pathogen Helicobacter pylori (1997) (3551)
The Minimal Gene Complement of Mycoplasma genitalium (1995) (2582)
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome (2010) (2213)
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi (1997) (2043)
The Genome Sequence of the Malaria Mosquito Anopheles gambiae (2002) (2020)
The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific (2007) (1959)
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae (2000) (1790)
Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima (1999) (1494)
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae (2001) (1380)
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus (1997) (1355)
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. (2000) (1150)
Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii (1996) (1149)
Design and synthesis of a minimal bacterial genome (2016) (1022)
Complete genome sequence of Treponema pallidum, the syphilis spirochete. (1998) (1009)
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome (2008) (996)
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. (1999) (919)
Global transposon mutagenesis and a minimal Mycoplasma genome. (1999) (900)
Essential genes of a minimal bacterium. (2006) (874)
Genome sequence of the dissimilatory metal ion–reducing bacterium Shewanella oneidensis (2002) (816)
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. (1970) (729)
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii (2002) (729)
A simple method for DNA restriction site mapping. (1976) (727)
Generating a synthetic genome by whole genome assembly: φX174 bacteriophage from synthetic oligonucleotides (2003) (537)
A restriction enzyme from Hemophilus influenzae: II. Base sequence of the recognition site (1970) (484)
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. (1998) (482)
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome (2008) (420)
Restriction endonucleases in the analysis and restructuring of dna molecules. (1975) (404)
A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome (2002) (389)
Letter: A suggested nomenclature for bacterial host modification and restriction systems and their enzymes. (1973) (377)
Genetic transformation. (1981) (365)
Shotgun Sequencing of the Human Genome (1998) (342)
A new strategy for genome sequencing (1996) (333)
Chemical synthesis of the mouse mitochondrial genome (2010) (328)
A phage P22 gene controlling integration of prophage. (1967) (279)
Genome transplantation in bacteria: changing one species to another. (2007) (274)
Prediction of transcription terminators in bacterial genomes. (2000) (271)
Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast (2009) (268)
Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome. (1995) (220)
Genome Transplantation in Bacteria: Changing One Species to Another (2007) (215)
Finding sequence motifs in groups of functionally related proteins. (1990) (211)
Designer diatom episomes delivered by bacterial conjugation (2015) (201)
[46] Recovery of DNA from gels (1980) (188)
An eleven-base-pair sequence determines the specificity of DNA uptake in Haemophilus transformation. (1980) (183)
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing (1978) (169)
Cell-free cloning using φ29 DNA polymerase (2005) (160)
Nucleotide sequence specificity of restriction endonucleases. (1979) (150)
Erratum: The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus (1998) (138)
DNA uptake signal sequences in naturally transformable bacteria. (1999) (134)
Specificity of Hpa II and Hae III DNA methylases. (1977) (133)
Sequence-specific DNA uptake in Haemophilus transformation. (1979) (131)
TWO SEQUENTIAL REPRESSIONS OF DNA SYNTHESIS IN THE ESTABLISHMENT OF LYSOGENY BY PHAGE P22 AND ITS MUTANTS. (1964) (123)
A restriction enzyme from Hemophilus influenzae. II. (1970) (121)
Transformasomes: specialized membranous structures that protect DNA during Haemophilus transformation. (1983) (119)
EcoRII can be activated to cleave refractory DNA recognition sites. (1988) (118)
Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14 (2002) (111)
Nucleotide sequence of a cluster of genes involved in the transformation of Haemophilus influenzae Rd. (1991) (108)
The First Epistle to the Corinthians (2015) (86)
Transposon mutagenesis, characterization, and cloning of transformation genes of Haemophilus influenzae Rd (1989) (85)
Cloning of restriction and modification genes in E. coli: the HbaII system from Haemophilus haemolyticus. (1978) (83)
Isolation and characterization of mutants of Haemophilus influenzae deficient in an adenosine 5'-triphosphate-dependent deoxyribonuclease activity (1975) (80)
Defective phage formation by lysogens of integration deficient phage P22 mutants. (1968) (80)
Organization of the Haemophilus influenzae Rd genome (1989) (76)
Cell-free cloning using phi29 DNA polymerase. (2005) (75)
Essential metabolism for a minimal cell (2019) (72)
Sequence organization of a cloned tDNA1 met fragment from xenopus laevis (1978) (71)
Cloning whole bacterial genomes in yeast (2010) (67)
A bacterial artificial chromosome library for soybean PI 437654 and identification of clones associated with cyst nematode resistance (1999) (64)
Identification of Haemophilus influenzae Rd transformation genes using cassette mutagenesis. (1999) (62)
Assembly of large, high G+C bacterial DNA fragments in yeast. (2012) (61)
Directional transport and integration of donor DNA in Haemophilus influenzae transformation. (1983) (61)
Direct transfer of whole genomes from bacteria to yeast (2013) (60)
DNA methylases of Hemophilus influenzae Rd. I. Purification and properties. (1973) (60)
Minimal Cells-Real and Imagined. (2017) (58)
On the sequencing and assembly of the human genome (2002) (56)
Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides. (1991) (56)
A peroxide/ascorbate-inducible catalase from Haemophilus influenzae is homologous to the Escherichia coli katE gene product (1994) (54)
Characterization and virulence analysis of catalase mutants of Haemophilus influenzae (1994) (54)
Sizing of the Haemophilus influenzae Rd genome by pulsed-field agarose gel electrophoresis (1988) (53)
A systems biology tour de force for a near-minimal bacterium (2009) (53)
Construction of DNA recognition sites active in Haemophilus transformation. (1982) (53)
Single-step linker-based combinatorial assembly of promoter and gene cassettes for pathway engineering (2011) (52)
Assembly of eukaryotic algal chromosomes in yeast (2013) (51)
The nucleotide sequence of the HhaII restriction and modification genes from Haemophilus haemolyticus. (1983) (51)
Gene order in prophage P22. (1965) (51)
Sequence analysis of a complete 1.66 Mb Prochlorococcus marinus MED4 genome cloned in yeast (2012) (50)
In vitro Tn7 mutagenesis of Haemophilus influenzae Rd and characterization of the role of atpA in transformation (1997) (48)
DNA methylases of Hemophilus influenzae Rd. II. Partial recognition site base sequences. (1973) (48)
Processing of donor DNA during Haemophilus influenzae transformation: analysis using a model plasmid system. (1985) (45)
A New Transformation-Deficient Mutant ofHaemophilus influenzae Rd with Normal DNA Uptake (1998) (42)
Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor. (1976) (41)
Reexamination of phenotypic defects in rec-1 and rec-2 mutants of Haemophilus influenzae Rd (1985) (41)
Cloning the Acholeplasma laidlawii PG-8A genome in Saccharomyces cerevisiae as a yeast centromeric plasmid. (2012) (40)
An adenosine triphosphate-dependent deoxyribonuclease from Hemophilus influenzae Rd. I. Purification and properties of the enzyme. (1972) (39)
Heterologous Expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] Hydrogenases in Synechococcus elongatus (2011) (39)
Discovery of [NiFe] Hydrogenase Genes in Metagenomic DNA: Cloning and Heterologous Expression in Thiocapsa roseopersicina (2009) (38)
THE SYNTHESIS OF PHAGE AND HOST DNA IN THE ESTABLISHMENT OF LYSOGENY. (1965) (37)
Transferring whole genomes from bacteria to yeast spheroplasts using entire bacterial cells to reduce DNA shearing (2014) (37)
Fundamental behaviors emerge from simulations of a living minimal cell (2022) (35)
Cloning and sequencing the HinfI restriction and modification genes. (1988) (35)
Genetics of ribosomal protein methylation in Escherichia coli (2004) (34)
The independence of our genome assemblies (2003) (28)
Mechanism of DNA degradation by the ATP-dependent DNase from Hemophilus influenzae Rd. (1976) (28)
[NiFe] Hydrogenase from Alteromonas macleodii with Unusual Stability in the Presence of Oxygen and High Temperature (2011) (28)
DNA sequences coding for the H2B histone of Psammechinus miliaris (1977) (27)
Methylases of the Type II Restriction-Modification Systems (1984) (26)
Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells. (2018) (26)
Heterologous expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] hydrogenases in Escherichia coli. (2011) (25)
Recombination-deficient Mutant of Salmonella typhimurium (1968) (24)
Transformation inHaemophilus: A problem in membrane biology (2005) (24)
Measurement of DNA-protein equilibria using gel chromatography: application to the HinfI restriction endonuclease. (1985) (22)
Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling (2015) (22)
Two Haemophilus influenzae Rd genes that complement the recA-like mutation rec-1 (1989) (22)
Construction of an efficient overproducer clone of HinfI restriction endonuclease using the polymerase chain reaction. (1990) (20)
Abolition of DNA recognition site resistance to the restriction endonuclease EcoRII. (1988) (19)
Production of possible recombination intermediates by an ATP-dependent DNAase. (1973) (19)
An adenosine triphosphate-dependent deoxyribonuclease from Hemophilus influenzae Rd. 3. Substrate specificity. (1972) (19)
Polar Effects of Transposon Insertion into a Minimal Bacterial Genome (2019) (19)
Comparative Sequencing (1996) (18)
The malaria genome sequencing project: complete sequence of Plasmodium falciparum chromosome 2. (1999) (18)
The Evolution of RecD Outside of the RecBCD Complex (2009) (18)
A Restriction Enzyme from Hemophilus influenzae II. Base Sequence of the Recognition Site (1989) (17)
An adenosine triphosphate-dependent deoxyribonuclease from Hemophilus influenzae Rd. II. Adenosine triphosphatase properties. (1972) (16)
Role of the two-component signal transduction and the phosphoenolpyruvate: carbohydrate phosphotransferase systems in competence development of Haemophilus influenzae Rd (1996) (16)
Mechanism of homospecific DNA uptake in Haemophilus influenzae transformation (1980) (16)
One step engineering of the small-subunit ribosomal RNA using CRISPR/Cas9 (2016) (15)
Preliminary x‐ray diffraction analysis of HhaII endonuclease‐DNA cocrystals (1986) (14)
Dual organism design cycle reveals small subunit substitutions that improve [NiFe] hydrogenase hydrogen evolution (2013) (14)
Catalytic properties of the HhaII restriction endonuclease. (1985) (13)
Binding of the ATP-dependent DNase from Hemophilus influenzae to duplex DNA molecules. (1976) (13)
Recombination-deficient Mutant of Salmonella typhimurium (1968) (13)
Initial steps in Haemophilus influenzae transformation. Donor DNA binding in the com10 mutant. (1986) (12)
Phage P22 lysogens of a Salmonella typhimurium mutant deleted at the normal prophage attachment site. (1968) (11)
Action of ATP-dependent DNase from Hemophilus influenzae on cross-linked DNA molecules. (1976) (10)
Direct Transfer of a Mycoplasma mycoides Genome to Yeast Is Enhanced by Removal of the Mycoides Glycerol Uptake Factor Gene glpF. (2019) (10)
The Malaria Genome Sequencing Project (1998) (10)
Genetic analysis of the Alteromonas macleodii [NiFe]-hydrogenase. (2011) (9)
Rescue of mutant fitness defects using in vitro reconstituted designer transposons in Mycoplasma mycoides (2014) (9)
Corrections: The complete genome sequence of the gastric pathogen Helicobacter pylori (1997) (9)
A broad survey reveals substitution tolerance of residues ligating FeS clusters in [NiFe] hydrogenase (2014) (9)
Enzymatic methods for sequence analysis applied to DNA restriction and methylation sites. (1974) (8)
Kinetic Modeling of the Genetic Information Processes in a Minimal Cell (2019) (8)
Purification of the HhaII restriction endonuclease from an overproducer Escherichia coli clone. (1985) (8)
Overproduction and purification of the M.HhaII methyltransferase from Haemophilus haemolyticus. (1988) (8)
Genome Shotgun Sequencing of the Sargasso Sea (2011) (8)
The malaria genome sequencing project. (1998) (7)
Purification and properties of HindII and HindIII endonucleases from Haemophilus influenzae Rd. (1980) (7)
Comparative sequencing [1] (1996) (5)
Sequencing the genome of Plasmodium falciparum (1998) (5)
Designed Surface Residue Substitutions in [NiFe] Hydrogenase that Improve Electron Transfer Characteristics (2015) (5)
New insights into how bacteria take up DNA during transformation. (1980) (4)
chemical synthesis of the mouse mitochondrial (2010) (4)
Use of synthetic ribosome binding site for overproduction of the 5B protein of insertion sequence IS5. (1989) (4)
The Restriction and Modification DNA Methylases: An Overview (1984) (4)
Synthesis and overproduction of the 5A protein of insertion sequence IS5 (1988) (3)
A preliminary comparison of the mouse and human genomes (2002) (2)
[72] The isolation and characterization by sucrose gradients of DNA from phage-infected bacterial cells (1967) (2)
errata: The yeast genome directory (1997) (2)
Restriction and modification enzymes detect no allosteric changes in DNA with bound lac repressor or RNA polymerase. (1981) (2)
Species to Another Genome Transplantation in Bacteria : Changing One (2007) (2)
Hervé Tettelin pneumoniae Streptococcus Complete Genome Sequence of a Virulent Isolate of (2013) (2)
Hydrogen from Water in a Novel Recombinant Cyanobacterial System (2014) (2)
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. 1970. (1992) (1)
Assembly of eukaryotic algal chromosomes in yeast (2013) (1)
Synthetic Cells and Minimal Life (2018) (1)
II . I . 5 Hydrogen from Water in a Novel Recombinant O 2-Tolerant Cyanobacterial System (2009) (1)
Biological roles of DNA methylation: An overview (1982) (1)
Cell-free cloning using U+03A6:29 DNA polymerase (2005) (1)
The Second International Conference on Forensic Activation Analysis Glasgow—September 1972 (1973) (1)
Hydrogen from Water in a Novel Recombinant Oxygen-Tolerant Cyanobacterial System (Presentation) (2007) (1)
How Many Genes Does a Cell Need (2008) (1)
Dual organism design cycle reveals small subunit substitutions that improve [NiFe] hydrogenase hydrogen evolution (2013) (1)
A half-century of inspiration: an interview with Hamilton Smith. Interview by Jane Gitschier. (2012) (0)
The Gospel of Mark (2007) (0)
Change and Decay (1974) (0)
Testimony of Hamilton Othanel Smith (1991) (0)
A ghent centenary (1980) (0)
The Epistle to the Ephesians (2015) (0)
Christmas and Carol (2021) (0)
The Epistle to the Romans (2008) (0)
A process for an organic substance entzorgung (1998) (0)
The Epistles of Peter (2015) (0)
The Epistle to the Colossians (2009) (0)
Plea to the Scientific Community (1982) (0)
Abraham: The Friend of God (2001) (0)
Fundamental cell behavior emerges from whole cell simulations of a minimal cell by integrating experiment and theory (2022) (0)
Genome Creation of a Bacterial Cell Controlled by a Chemically Synthesized (2011) (0)
II.F.1 Hydrogen from Water in a Novel Recombinant O2-Tolerant Cyanobacterial System II.F Biological Production (2008) (0)
Modelling the Genetic Information Processes of a Genetically Minimal Cell (2020) (0)
Size of 5′- Terminal Fragments Cleaved from Poly(dG-dC) by Endo R · Hha I (1977) (0)
Modeling the Lipid Metabolism of a Genetically Minimal Cell (2020) (0)
Where Next for Microbiome Research? The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2015) (0)
Author response: Essential metabolism for a minimal cell (2018) (0)
development of Haemophilus influenzae Rd. phosphotransferase systems in competence and the phosphoenolpyruvate: carbohydrate Role of the two-component signal transduction (2013) (0)
Another Genome Transplantation in Bacteria : Changing One Species to (2011) (0)
Amplification and cloning of individual DNA molecules by rolling-circle amplification (2006) (0)
Construction of a Bacterial Cell that Contains Only the Set of Essential Genes Necessary to Impart Life (2013) (0)
Carole Lartigue Engineered in Yeast Creating Bacterial Strains from Genomes That Have Been Cloned and (2011) (0)
EXPLORING THE OCEAN'S MICROBES: SEQUENCING THE SEVEN SEAS (2006) (0)
1980 Beaumont Lecture. Restriction enzymes as tools for genetic research. (1980) (0)
Method of nucleic acid cassette assembly (2006) (0)
Modelling the Nucleotide Metabolic Network of a Genetically Minimal Cell (2020) (0)
Gross Chromosomal Rearrangements in Kluyveromyces marxianus Revealed by Illumina and Oxford Nanopore Sequencing (2020) (0)
Estimation of the Minimal Mycoplasma Gene Set Using Global Transposon Mutagenesis and Comparative Genomics (2005) (0)

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