John Savill | Academic Influence

Q: What Schools Are Affiliated With John Savill

John Savill is affiliated with the following schools: University of Sheffield, University of Nottingham, University of Oxford, University of Edinburgh, Royal Postgraduate Medical School, University of Birmingham

Why Is John Savill Influential?

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According to Wikipedia, Sir John Stewart Savill, FRS, FMedSci is the Chief Executive of the Medical Research Council in the UK and the Head of the College of Medicine and Veterinary Medicine and a Vice Principal of the University of Edinburgh.

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John Savill's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Resolution of inflammation: the beginning programs the end (2005) (2292)
A blast from the past: clearance of apoptotic cells regulates immune responses (2002) (1677)
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. (1989) (1662)
Corpse clearance defines the meaning of cell death (2000) (1634)
Phagocyte recognition of cells undergoing apoptosis. (1993) (1058)
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis (1990) (923)
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. (1992) (840)
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo (2000) (762)
Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. (1992) (649)
Apoptosis in resolution of inflammation (1997) (593)
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis (2006) (501)
Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. (1994) (424)
CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis (1995) (421)
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment (2002) (390)
Apoptosis: The importance of being eaten (1998) (373)
Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression. (1994) (363)
Recognition and phagocytosis of cells undergoing apoptosis. (1997) (350)
Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2 (1992) (321)
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. (1999) (317)
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells (2007) (315)
Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism. (1989) (315)
Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation1 (2002) (311)
Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. (1992) (310)
Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes. (1999) (304)
Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. (2002) (302)
Granulocyte apoptosis and the control of inflammation. (1994) (273)
Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response. (1996) (271)
Apoptosis: Phagocytic docking without shocking (1998) (260)
Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation1 (2005) (249)
Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death (2004) (237)
Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. (1994) (222)
Apoptotic Cells and Innate Immune Stimuli Combine to Regulate Macrophage Cytokine Secretion 1 (2003) (220)
Granulocyte clearance by apoptosis in the resolution of inflammation. (1995) (207)
Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins (2007) (201)
Constitutive Death of Platelets Leading to Scavenger Receptor-mediated Phagocytosis (2000) (182)
Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis. (1995) (174)
Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis. (1992) (171)
Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype1 (2005) (160)
Local Amplification of Glucocorticoids by 11β-Hydroxysteroid Dehydrogenase Type 1 Promotes Macrophage Phagocytosis of Apoptotic Leukocytes1 (2006) (160)
Apoptosis and the kidney. (1994) (156)
Apoptosis in resolution of inflammation. (2000) (155)
Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro. (1993) (150)
Actin is cleaved during constitutive apoptosis. (1997) (149)
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death (2003) (149)
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. (2007) (143)
A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells (2011) (139)
A possible role for bcl-2 in regulating T-cell memory--a 'balancing act' between cell death and survival. (1993) (136)
Activated Macrophages Direct Apoptosis and Suppress Mitosis of Mesangial Cells1 (2000) (132)
Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion. (1997) (132)
Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses1 (2006) (132)
Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases* (1998) (124)
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. (2011) (114)
Nonphlogistic Clearance of Late Apoptotic Neutrophils by Macrophages: Efficient Phagocytosis Independent of β2 Integrins1 (2001) (114)
Science, medicine, and the future Non-insulin dependent diabetes mellitus: the gathering storm (1997) (112)
Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock1 (2008) (109)
Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype (2005) (106)
Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils* (1996) (98)
Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation (2013) (98)
Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis. (1997) (95)
The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response (2009) (91)
Eat Me or Die (2003) (91)
Dissociation of Phagocyte Recognition of Cells Undergoing Apoptosis from Other Features of the Apoptotic Program* (1998) (89)
11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice (2011) (86)
Apoptosis in disease (1994) (86)
Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals. (1999) (85)
The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections (1994) (82)
Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation. (2006) (76)
Macrophage vitronectin receptor, CD36, and thrombospondin cooperate in recognition of neutrophils undergoing programmed cell death. (1991) (71)
Local Amplification of Glucocorticoids by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Inflammatory Response (2006) (70)
Coupling of neutrophil apoptosis to recognition by macrophages: coordinated acceleration by protein synthesis inhibitors (1997) (69)
The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis. (1999) (69)
Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis. (1997) (67)
Membranous nephropathy caused by mercury-containing skin lightening cream. (1987) (67)
Regulation of glomerular cell number by apoptosis. (1999) (66)
Selective Sensitization to Tumor Necrosis Factor-α-induced Apoptosis by Blockade of NF-κB in Primary Glomerular Mesangial Cells* (1999) (64)
Macrophage recognition of senescent neutrophils. (1992) (63)
Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages. (2001) (61)
Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications (2002) (57)
Apoptosis and renal scarring. (1996) (55)
The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours (2001) (54)
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis (2013) (53)
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage (2016) (50)
Apoptosis (programmed cell death) and functional changes in aging neutrophils. Modulation by inflammatory mediators. (1991) (50)
αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells (2016) (47)
Phagocyte recognition of apoptotic cells. (1996) (46)
Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus. (1988) (45)
Cell biology. Eat me or die. (2003) (45)
Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis. (2006) (45)
Apoptotic PS to phagocyte TIM-4: eat me. (2007) (38)
A 19‐year‐old man with leucocyte adhesion deficiency. In vitro and in vivo studies of leucocyte function (1991) (33)
Management of hypertension in patients developing end-stage renal failure. (1999) (32)
The neutrophil. (1989) (32)
The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets (2005) (31)
Apoptosis: a mechanism for regulation of the cell complement of inflamed glomeruli. (1992) (29)
11β-Hydroxysteroid dehydrogenase type 1—A role in inflammation? (2006) (29)
Glomerular remodelling after inflammatory injury. (1995) (27)
Corrigendum: Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis (2006) (26)
CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells (2007) (25)
11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice (2016) (24)
Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation (2013) (23)
Selective sensitization to tumor necrosis factor-alpha-induced apoptosis by blockade of NF-kappaB in primary glomerular mesangial cells. (1999) (22)
Apoptosis and renal injury. (1995) (21)
A database on global health research in Africa. (2013) (21)
What role does apoptosis play in progression of renal disease? (1996) (21)
Phagocyte recognition of ''- cens undergoing (1993) (21)
Apoptosis in glomerulonephritis (2005) (21)
Apoptosis and glomerulonephritis. (2006) (20)
Relationship between granulocyte activation, pulmonary granulocyte kinetics and alveolar permeability in extrapulmonary inflammatory disease. (1996) (20)
Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy (2019) (19)
11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation? (2006) (17)
Towards a more rapid diagnosis of rapidly progressive glomerulonephritis. (1990) (17)
Why is apoptosis important to clinicians? (2001) (16)
Apoptosis and the prostate. (1995) (16)
Science, medicine, and the future: Prospecting for gold in the human genome (1997) (15)
United Kingdom (1997) (14)
The fate of the neutrophil in vasculitis (1993) (12)
Apoptosis: will cell death add life to nephrology? (1995) (12)
Ganciclovir treatment for cytomegalovirus infection in immunocompromised patients with renal disease. (1991) (12)
Apoptosis in post-streptococcal glomerulonephritis. (2001) (12)
Pneumococcal bacteraemia in mother and son. (1983) (10)
PHAGOCYTE RECOGNITION OF CELLS UNDERGOING APOPTOSIS (1996) (10)
Macrophage recognition of senescent granulocytes. (1990) (10)
Inhibition of Macrophage Phagocytosis in Vitro of Aged Neutrophils Undergoing Apoptosis Increases Release of Neutrophil Contents (1993) (10)
Apoptosis in glomerulonephritis. (2004) (8)
Apoptosis: from worm to wonder-drug? (1995) (8)
Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis. (1988) (7)
Phagocyte clearance of cells dying by apoptosis and the regulation of glomerular inflammation. (2001) (7)
Rapid plasma digoxin assay in outpatients--a useful routine technique? (1985) (7)
Science, medicine, and the future: Molecular genetic approaches to understanding disease (1997) (7)
Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity (2007) (7)
EXPRESSION OF THE MULTIFUNCTIONAL EXTRACELLULAR MATRIX PROTEIN THROMBOSPONDIN IN CRESCENTIC GLOMERULONEPHRITIS (1996) (7)
Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity (2019) (7)
Macrophage secretory responses to ingestion of aged neutrophils (1989) (6)
Country profile: United Kingdom. (1997) (5)
Chronic renal failure associated with topical application of paraphenylenediamine (1987) (5)
Scientist-industry partnerships do not constitute a “tangled web” (2015) (4)
Apoptotic Cell–Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin–Mediated Induction of Regulatory T Lymphocytes (2020) (4)
Science, medicine, and the future: Role of molecular cell biology in understanding disease (1997) (4)
UK funders' framework for health-related findings in research (2014) (3)
Apoptotic Cell Phagocytosis (2000) (3)
Mastering Microsoft Azure Infrastructure Services (2015) (3)
Dynamic Regulation of 11$\-Hydroxysteroid Dehydrogenase Type 1 in Neutrophils during an Inflammatory Response (2011) (3)
National Health under new management (1997) (2)
Thrombospondin (TSP), CD36 and Macrophage Vitronectin Receptor (VnR) Co-Operate in Phagocytosis of Neutrophils Undergoing Programmed Cell Death (Apoptosis) (1991) (2)
Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation (2020) (2)
Academic paediatrics: Easter Island or Easter Sunday? (2005) (2)
Neutrophils Undergoing Apoptosis are Ingested by Mesangial Cells: A Regulated Mechanism for Neutrophil Clearance from Glomeruli (1991) (1)
11[beta]-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids (2009) (1)
Windows Server 2003 Active Directory Design and Implementation: Creating, Migrating, and Merging Networks (2005) (1)
PROTEASE INHIBITION DISSOCIATES RECOGNITION BY MACROPHAGES FROM OTHER FEATURES OF CONSTITUTIVE APOPTOSIS IN THE NEUTROPHIL (1996) (1)
New management for Brisbane's natural assets (2008) (1)
Conditional deletion of alpha (v) integrins causes inflammatory bowel disease. (2005) (1)
Glucocorticoid steroids increase uptake of apoptotic cells by glomerular phagocytes (1997) (1)
A 19-YEAR-OLD MAN WITH LEUKOCYTE ADHESION DEFICIENCY - INVITRO AND INVIVO STUDIES OF LEUKOCYTE FUNCTION (1991) (1)
Catastrophic neglect of basic sciences in medicine (2012) (0)
Anti-Phospholipid Autoantibody-Positive Sera Interfere with Phosphatidylserine (PS)-Dependent Recognition of Apoptotic Cells by Macrophages (Mø) (1997) (0)
Characterization of the Macrophage Integrin Which Mediates Phagocytosis of Aged Neutrophils (1990) (0)
CONSTITUTIVE APOPTOSIS IN NEUTROPHILS DOES NOT EXHIBIT CHARACTERISTICS OF FAS-MEDIATED DEATH (1996) (0)
Granulocyte-macrophage colony-stimulating factor (1989) (0)
Human Neutrophils from Inflamed Joints Undergo Apoptiosis and are Engulfed by Macrophages in Vitro (1988) (0)
Oral abstracts 7: Molecular mechanisms of disease—osteoarthritisS1. Identification of novel osteoarthritis genes using zebrafish (2012) (0)
11β-HSD1: anti-inflammatory mechanism in acute and chronic inflammation? (2006) (0)
Macrophages Condition the Milieu in Which Dcs Encounter Antigen (2002) (0)
Antineutrophil Cytoplasmic Antibodies (ANCA) Induce Dysregulated Neutrophil (PMN) Apoptosis (1999) (0)
A Novel Inducible Stroke Phenotype Created by Correction of Salt-Water Loss during Accelerated Hypertension (2002) (0)
Microsoft Azure Infrastructure Services for Architects: Designing Cloud Solutions (2019) (0)
Glomerular healing. (1996) (0)
Extracellular matrix protein promotes survival of human colonic sub-epithelial myofibroblasts by beta1-integrin dependent inhibition of apoptosis (1998) (0)
Low priority given to original research in the new print version of The BMJ (2015) (0)
Mastering Hyper-V 2012 R2 with System Center and Windows Azure (2014) (0)
Attenuated atherosclerosis in 11[beta]-hydroxysteroid dehydrogenase type 1 deficient ApoE-/- mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat (2011) (0)
Mechanisms of Cytokine-Mediated Potentiation of Macrophage Phagocytosis of Neutrophils Undergoing Apoptosis (1992) (0)
Antibody and complement dependent regulation of apoptosis in anti-Thy.1 nephritis in rats (1998) (0)
CD36 Gene Transfer Confers Capacity for Phagocytosis of Lymphoid and Mesenchymal Cells Undergoing Apoptosis (1995) (0)
Steroids increase non-phlogistic uptake of apoptotic cells by glomerular phagocytes (1997) (0)
MacRophage Responses to the Ingestion of Aged Neutrophils (1989) (0)
The Human Mesangial Cell Vitronectin Receptor Mediates Phagocytosis of Senescent Neutrophils (1993) (0)
Cell Maturation upon Endotoxin-Driven Myeloid Dendritic Inhibitory Effects of Apoptotic Cell Ingestion (2002) (0)
Dendritic Cells Ingesting Apoptotic Neutrophils Fail to Mature in Response to LPS Stimulation (2002) (0)
Letter to the Editor (2014) (0)
The role of C1q and apoptotic bridging molecules in the recognition and clearance of apoptotic neutrophils in SLE. (2002) (0)
Microsoft Azure Infrastructure Services for Architects (2019) (0)
Clearance of apoptotic cells and the control of inflammation (2009) (0)
Windows XP/2000 Answer Book: A Completer Resource from the Desktop to the Enterprise (2002) (0)
Macrophage Release of Tumour Necrosis Factor Directs Mesangial Cell Apoptosis and is Inhibited by Uptake of Apoptotic Cells; a Negative Feedback Loop in the Inflammatory Response (2002) (0)
TLR9 INDUCES TOLERANCE TO APOPTOTIC CELLS AND IS RESPONSIBLE FOR INDUCING REGULATORY B CELLS (2012) (0)
Specific Inhibition of Macrophage Phagocytosis of Senescent Human Neutrophils by Monosaccharides (1987) (0)
More than merely academic (1999) (0)
Interleukin 1β and Tumour Necrosis Factor α Induce Apoptosis in Renal Mesangial Cells In Vitro (1997) (0)
Suppress Mitosis of Mesangial Cells Activated Macrophages Direct Apoptosis and (2000) (0)
Extracellular Matrix (ECM) Proteins Confer Survival upon Glomerular Cells by Inhibiting Apoptosis (1996) (0)
SecretionCombine to Regulate Macrophage Cytokine Apoptotic Cells and Innate Immune Stimuli (2003) (0)
Initiate Acute Peritoneal Inflammation Demonstrates That Resident Macrophages Conditional Macrophage Ablation (2005) (0)
The Role of Cytosolic Calcium ([Ca2+]i) in the Inhibition of Neutrophil Apoptosis in vitro (1993) (0)
Proposed siting of the new national clinical research centre (1987) (0)
Lipopolysaccharide-Induced Shock Apoptotic Cells Protect Mice against (2008) (0)
Phagocytosis of Apoptotic Leukocytes Glucocorticoids Promote Nonphlogistic (1999) (0)
Transfection with Cd36 Cdna of Cd36-Negative Cell Lines Confers Capacity to Recognise Senescent Neutrophils Undergoing Apoptosis (1994) (0)
The Windows NT and Windows 2000 Answer Book: A Complete Resource from the Desktop to the Enterprise (1999) (0)
Devaluing clinical skills. Clinical skills are valued by clinical academics. (2000) (0)
but No Autoimmune Phenotype Display Defective Apoptotic Cell Clearance Mannose-Binding Lectin-Deficient Mice (2013) (0)

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Other Resources About John Savill

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What Schools Are Affiliated With John Savill?

John Savill is affiliated with the following schools: