Joseph L. Goldstein

Joseph L. Goldstein's AcademicInfluence.com Rankings

Joseph L. Goldstein

Biology

#83

World Rank

#151

Historical Rank

#48

USA Rank

Biochemistry

#13

World Rank

#16

Historical Rank

USA Rank

biology Degrees

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Biology

Why Is Joseph L. Goldstein Influential?

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According to Wikipedia, Joseph Leonard Goldstein ForMemRS is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.

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Joseph L. Goldstein's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A receptor-mediated pathway for cholesterol homeostasis. (1986) (5399)
Regulation of the mevalonate pathway (1990) (5139)
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. (2002) (4361)
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor (1997) (3604)
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. (1979) (2368)
Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. (1983) (2212)
The low-density lipoprotein pathway and its relation to atherosclerosis. (1977) (2190)
Coated pits, coated vesicles, and receptor-mediated endocytosis (1979) (1874)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. (2000) (1684)
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. (1993) (1555)
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ (2000) (1504)
Protein Sensors for Membrane Sterols (2006) (1494)
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. (1983) (1478)
Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. (1973) (1427)
Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to Humans (2000) (1374)
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. (1985) (1370)
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes (2003) (1331)
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. (1999) (1321)
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. (1974) (1233)
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA (1984) (1175)
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia (1992) (1140)
Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone (2008) (1107)
The LDL receptor. (2009) (1065)
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy (1999) (1018)
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. (1980) (1013)
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis (1994) (975)
Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER (2002) (942)
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. (1976) (927)
Regulation of plasma cholesterol by lipoprotein receptors. (1981) (893)
Selective versus total insulin resistance: a pathogenic paradox. (2008) (854)
Receptor-mediated control of cholesterol metabolism. (1976) (846)
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. (1996) (830)
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. (2000) (826)
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. (1990) (823)
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. (2000) (818)
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. (1998) (809)
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. (1997) (800)
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. (1999) (799)
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. (1997) (779)
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015) (764)
The LDL receptor gene: a mosaic of exons shared with different proteins. (1985) (751)
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. (1994) (739)
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. (1990) (716)
The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. (1980) (703)
Recycling receptors: The round-trip itinerary of migrant membrane proteins (1983) (703)
Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides (1990) (701)
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. (1998) (695)
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis (2010) (654)
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c* (2002) (634)
Receptor-mediated endocytosis: insights from the lipoprotein receptor system. (1979) (623)
Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts (1977) (619)
Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol (2009) (597)
Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. (1973) (588)
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. (1993) (584)
Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. (1993) (579)
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. (2004) (550)
Hyperlipidemia in Coronary Heart Disease (1973) (544)
39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1991) (539)
Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle (1994) (531)
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. (1989) (530)
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. (1983) (524)
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts (1981) (521)
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins (1979) (520)
How LDL receptors influence cholesterol and atherosclerosis. (1984) (516)
Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment (1996) (512)
Beyond the Best Interests of the Child (1974) (511)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig (2007) (510)
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins (2002) (504)
Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol. (1979) (503)
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias. (1974) (503)
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR (2001) (498)
The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. (1980) (492)
Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans (1976) (490)
Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein (1996) (478)
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. (1978) (475)
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. (1997) (465)
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. (2008) (453)
The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. (1994) (453)
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. (1997) (451)
Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia. (1983) (447)
The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E. (1980) (440)
Structure of the LDL Receptor Extracellular Domain at Endosomal pH (2002) (440)
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. (1974) (439)
Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells* (2001) (438)
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes (2008) (436)
Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts (1983) (436)
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. (1992) (435)
Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. (1974) (435)
Regulation of the activity of the low density lipoprotein receptor in human fibroblasts (1975) (431)
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. (2002) (416)
Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. (1998) (408)
Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs* (2004) (402)
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. (1982) (400)
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. (1985) (399)
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. (1973) (397)
Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. (1984) (396)
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. (1993) (393)
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region (1987) (392)
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. (1990) (391)
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice (2010) (388)
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. (1981) (381)
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation (2003) (370)
Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. (1984) (362)
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. (1975) (356)
Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity (1974) (353)
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. (2003) (351)
HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions (1984) (349)
Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. (1980) (349)
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. (1986) (339)
Police Discretion Not to Invoke the Criminal Process: Low-Visibility Decisions in the Administration of Justice (1960) (337)
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme (1985) (336)
The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors (1986) (335)
cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1 (*) (1995) (334)
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. (1996) (332)
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. (2001) (323)
Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes (2000) (323)
Transport-Dependent Proteolysis of SREBP Relocation of Site-1 Protease from Golgi to ER Obviates the Need for SREBP Transport to Golgi (1999) (322)
Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. (2004) (322)
Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor (1984) (319)
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein (1993) (314)
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. (1993) (313)
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. (1995) (313)
Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols. (1975) (312)
Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila (2002) (311)
Atherosclerosis: the low-density lipoprotein receptor hypothesis. (1977) (311)
Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight. (1982) (309)
Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro(*) (1995) (302)
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit (1991) (301)
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. (1995) (301)
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. (1993) (299)
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. (2005) (299)
The clinical investigator: bewitched, bothered, and bewildered--but still beloved. (1997) (295)
Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. (1976) (294)
Cellular Pathology of Progressive Atherosclerosis in the WHHL Rabbit: An Animal Model of Familial Hypercholesterolemia (1983) (293)
Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol* (2003) (291)
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. (1992) (289)
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. (1986) (288)
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme. (1988) (288)
Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins. (1989) (286)
Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. (1987) (286)
Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. (1978) (286)
Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. (1981) (284)
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis (2003) (284)
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product (1992) (284)
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. (1981) (282)
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. (1973) (282)
Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding (1992) (279)
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. (1980) (278)
Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. (1979) (278)
Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia (1987) (272)
The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum. (1987) (270)
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis. (1987) (269)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins (2007) (268)
Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. (1975) (268)
Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. (1981) (267)
Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states. (1979) (267)
Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. (1982) (266)
Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents. (1980) (266)
Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. (1975) (264)
Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species. (1980) (264)
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. (2012) (262)
Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor. (1983) (262)
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. (1995) (257)
Proteolytic processing of the 600 kd low density lipoprotein receptor‐related protein (LRP) occurs in a trans‐Golgi compartment. (1990) (256)
Retrospective on Cholesterol Homeostasis: The Central Role of Scap. (2018) (255)
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor. (1988) (253)
Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. (1981) (252)
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. (2002) (250)
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain (1985) (248)
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. (2001) (245)
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. (2004) (243)
A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts (1977) (242)
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. (1985) (241)
Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man (1974) (241)
Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. (1974) (241)
Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase. (1991) (240)
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis (2014) (236)
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. (2006) (235)
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. (1999) (234)
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene (2001) (233)
Visualization of acidic organelles in intact cells by electron microscopy. (1984) (233)
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. (1988) (233)
Microbeam Analysis 1984 (1984) (232)
Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦ (2005) (231)
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection (2015) (229)
Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein* (1997) (227)
Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia. (1975) (226)
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia. (1981) (224)
Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins* (1998) (224)
Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. (1990) (224)
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase (2012) (224)
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor. (1982) (222)
Molecular Characterization of Human Acetyl-CoA Synthetase, an Enzyme Regulated by Sterol Regulatory Element-binding Proteins* (2000) (222)
Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating Protein (1998) (220)
The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor (1983) (220)
Teaching old dogmas new tricks (1987) (218)
The Cholesterol Quartet (2001) (218)
Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor. (1976) (218)
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. (1990) (217)
SREBPs: transcriptional mediators of lipid homeostasis. (2002) (215)
Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells. (1977) (215)
The LDL receptor locus and the genetics of familial hypercholesterolemia. (1979) (214)
Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia (1982) (212)
Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies (1982) (212)
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. (2010) (209)
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. (2004) (208)
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. (2005) (205)
Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. (2009) (204)
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1982) (203)
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). (1994) (202)
Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane (*) (1996) (202)
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum (1984) (200)
Familial incomplete male pseudohermaphroditism, type 1. Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome. (1974) (200)
Lowering LDL--Not Only How Low, But How Long? (2006) (198)
Visualization of lipoprotein receptors by ligand blotting. (1983) (198)
Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia. (1987) (197)
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides (2008) (195)
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits. (1982) (194)
Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein (1976) (193)
Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. (1999) (192)
The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy. (1982) (192)
Seeking the Heart of Wisdom: The Path of Insight Meditation (1987) (191)
Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing Domain* (1998) (187)
Before the Best Interests of the Child (1973) (186)
Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol. (1986) (186)
Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: Relation to low density lipoprotein receptor distribution (1978) (184)
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. (1990) (181)
Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins* (1999) (179)
Scavenging for receptors (1990) (179)
Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis. (1987) (178)
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter (1987) (177)
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. (1990) (176)
Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein. (1975) (174)
CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB (*) (1995) (173)
Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2* (1997) (173)
Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts. (1978) (173)
Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat. (1977) (172)
The low-density lipoprotein receptor-related protein: double agent or decoy? (1991) (169)
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells (2009) (169)
The SREBP pathway in Drosophila: regulation by palmitate, not sterols. (2002) (168)
Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein* (1999) (166)
REP-2, a Rab escort protein encoded by the choroideremia-like gene. (1994) (165)
Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase. (1991) (164)
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. (1993) (162)
Purified NPC1 Protein (2008) (162)
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. (1975) (161)
Purified NPC1 Protein (2008) (161)
The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism. (1976) (161)
Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. (1988) (160)
Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts (1982) (160)
Lowering plasma cholesterol by raising LDL receptors. (1981) (159)
Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection * (1995) (159)
Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice (2010) (157)
Cassette of eight exons shared by genes for LDL receptor and EGF precursor. (1985) (156)
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe. (1983) (156)
Second-site Cleavage in Sterol Regulatory Element-binding Protein Occurs at Transmembrane Junction as Determined by Cysteine Panning* (1998) (153)
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. (1997) (153)
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. (1996) (152)
Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. (1983) (152)
Heart Attacks: Gone with the Century? (1996) (152)
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. (1986) (152)
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. (1987) (152)
Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization. (1972) (151)
Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells. (1983) (151)
Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue. (1979) (150)
Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle. (1978) (150)
One Dharma: The Emerging Western Buddhism (2002) (149)
Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. (1988) (146)
Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia. (1986) (146)
cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper. (1989) (145)
Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor. (1979) (143)
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. (2000) (143)
Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells. (1982) (143)
Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are allelic (1977) (141)
Purification of an Interleukin-1 Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains (*) (1995) (141)
Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair Follicles (1971) (141)
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells. (1989) (141)
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. (1983) (140)
Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells. (1979) (140)
LDL-receptor structure: Calcium cages, acid baths and recycling receptors (1997) (138)
Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. (1989) (137)
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. (1991) (137)
5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription (1985) (136)
Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. (2014) (133)
Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1988) (132)
cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1 (1991) (132)
Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages. (1979) (129)
Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia. (1986) (128)
Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease. (1984) (128)
Concentration and Composition of Lipoproteins in Blood Plasma of the WHHL Rabbit (1982) (127)
A Receptor‐Mediated Pathway for Cholesterol Homeostasis (Nobel Lecture) (1986) (125)
Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. (1998) (124)
Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia. (1982) (123)
Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia. (1978) (123)
Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. (1976) (122)
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. (1992) (121)
Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. (1979) (121)
Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo. (1979) (119)
Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction. (1973) (118)
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. (1992) (117)
Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles (2003) (115)
Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol. (1974) (113)
Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake. (2009) (112)
Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex. (1980) (111)
Purification of oxysterol binding protein from hamster liver cytosol. (1989) (111)
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. (1994) (111)
Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism. (1975) (110)
PxF, a prenylated protein of peroxisomes. (1994) (109)
Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. (1978) (109)
Membrane Topology of S2P, a Protein Required for Intramembranous Cleavage of Sterol Regulatory Element-binding Proteins* (1999) (109)
Molecular medicine. The cholesterol quartet. (2001) (108)
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice (1990) (107)
Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo. (1980) (107)
Familial hypercholesterolemia: a genetic receptor disease. (1985) (106)
Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro. (1977) (106)
Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. (1979) (105)
Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. (1994) (104)
Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. (1981) (104)
Lipoprotein receptors, cholesterol metabolism, and atherosclerosis. (1975) (104)
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes (2001) (104)
Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. (1990) (103)
Surviving starvation: essential role of the ghrelin-growth hormone axis (2012) (101)
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. (1988) (101)
Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1. (1997) (101)
Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum (1987) (101)
Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia (1976) (101)
Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids* (2012) (100)
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983. (1983) (100)
Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines (1995) (99)
First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. (1987) (99)
3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides. (1983) (97)
Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells (1984) (97)
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors. (1983) (96)
Stimulation of Cholesteryl Ester Synthesis in Macrophages by Extracts of Atherosclerotic Human Aortas and Complexes of Albumin/Cholesteryl Esters (1981) (96)
Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA. (1985) (95)
Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells (2013) (95)
Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol. (1983) (93)
Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1* (1998) (93)
Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA. (1982) (89)
Overexpression of Membrane Domain of SCAP Prevents Sterols from Inhibiting SCAP·SREBP Exit from Endoplasmic Reticulum* (2000) (88)
Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis* (2004) (88)
Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta. (2001) (86)
Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements. (1989) (85)
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA. (1986) (84)
Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. (1980) (84)
LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size* (2009) (83)
Recycling of cell-surface receptors: observations from the LDL receptor system. (1982) (83)
Familial hypercholesterolemia: pathogenesis of a receptor disease. (1978) (82)
Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization. (1988) (81)
Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. (1977) (81)
Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. (1991) (80)
Koch's postulates for cholesterol (1992) (79)
Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations. (1975) (79)
Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region. (1985) (79)
Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins* (1999) (79)
cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. (1990) (76)
Familial hypercholesterolemia in a large indred. Evidence for a monogenic mechanism. (1972) (76)
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. (2006) (76)
Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions. (1988) (76)
Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain. (1987) (76)
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. (1993) (76)
Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts. (1975) (76)
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. (1996) (75)
Insight Meditation: The Practice of Freedom (1993) (75)
The Best Interests of the Child: The Least Detrimental Alternative (1996) (75)
Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice (1992) (74)
EVOLUTION OF THE LDL RECEPTOR CONCEPT–FROM CULTURED CELLS TO INTACT ANIMALS * (1980) (71)
History of Discovery The LDL Receptor (2009) (71)
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro. (1994) (70)
Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role. (1993) (70)
Heterozygous familial hypercholesterolemia: Failure of normal allele to compensate for mutant allele at a regulated genetic locus (1976) (70)
Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis* (2011) (69)
The structure of human hemoglobin. VII. The digestion of the beta chain of human hemoglobin with pepsin. (1963) (69)
Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase. (1991) (69)
The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor. (1991) (69)
The LDL Receptor and the Regulation of Cellular Cholesterol Metabolism (1985) (67)
Mad Bet for Rab (1993) (67)
Solubilization of the low density lipoprotein receptor. (1979) (67)
Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone (2015) (66)
Erratum: Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL (Journal of Lipid Research (2009) 50 (S15-S27)) (2009) (66)
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). (1998) (65)
Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins. (1978) (65)
Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells (1981) (65)
Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex (1988) (64)
Medical care for the child at risk: on state supervention of parental autonomy. (1977) (64)
Targeted killing of cultured cells by receptor-dependent photosensitization. (1981) (63)
Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. (1979) (62)
THE LOW‐DENSITY LIPOPROTEIN PATHWAY IN HUMAN FIBROBLASTS: RELATION BETWEEN CELL SURFACE RECEPTOR BINDING AND ENDOCYTOSIS OF LOW‐DENSITY LIPOPROTEIN * (1976) (62)
Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice* (2009) (61)
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. (2005) (61)
The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. (1986) (60)
Plasma lipoproteins: teaching old dogmas new tricks. (1987) (59)
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. (1996) (58)
Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) (58)
Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins. (1989) (57)
Complementation of Mutation in Acyl-CoA:Cholesterol Acyltransferase (ACAT) Fails to Restore Sterol Regulation in ACAT-defective Sterol-resistant Hamster Cells* (1996) (57)
Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. (2006) (57)
Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. (1983) (57)
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts (1983) (56)
Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat. (1976) (55)
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits. (1987) (55)
LDL receptors in coated vesicles isolated from bovine adrenal cortex: Binding sites unmasked by detergent treatment (1980) (55)
Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation. (1992) (54)
On the origin and prevention of PAIDS (Paralyzed Academic Investigator's Disease Syndrome). (1986) (54)
Cystathionine synthase activity in human lymphocytes: induction by phytohemagglutinin. (1972) (54)
The Low-Density Lipoprotein Receptor (1987) (54)
PRENATAL DIAGNOSIS OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLÆMIA Expression of a Genetic Receptor Disease in Utero (1978) (54)
Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. (1987) (54)
Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids. (1979) (54)
Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone. (1978) (53)
Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts. (1976) (52)
Regulation of cholesterol synthesis in normal and malignant tissue. (1973) (51)
Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver. (1981) (50)
Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts. (1980) (50)
Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex (2016) (49)
Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1991) (49)
Evidence for increased cytoplasmic androgen binding in the submandibular gland of the mouse with testicular feminization. (1972) (48)
Linkage studies in a large kindred with familial hypercholesterolemia. (1974) (48)
Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice (2011) (47)
Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins* (2003) (47)
High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit. (1978) (47)
Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits. (1984) (47)
Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase. (1983) (46)
Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids. (1974) (46)
Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. (2010) (46)
Biologically active low density lipoprotein in human peripheral lymph. (1978) (45)
Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. (2005) (45)
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1 (2016) (44)
Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II. (1987) (43)
Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells (1975) (43)
Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts. (1978) (43)
HDL miR-ed Down by SREBP Introns (2010) (42)
Lipoprotein receptors and the control of plasma LDL cholesterol levels. (1992) (42)
Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia. (1983) (42)
The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis. (1985) (40)
A tribute to Akira Endo, discoverer of a “Penicillin” for cholesterol (2004) (40)
The Receptor Model for Transport of Cholesterol in Plasma a (1985) (39)
Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein (2009) (39)
Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection. (1974) (38)
Phosvitin kinase from the liver of the rooster. Purification and partial characterization. (1973) (38)
Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (1988) (37)
Hyperlipidemia in coronary heart disease: a biochemical genetic approach. (1975) (37)
Reconstitution of Sterol-regulated Endoplasmic Reticulum-to-Golgi Transport of SREBP-2 in Insect Cells by Co-expression of Mammalian SCAP and Insigs* (2003) (36)
Gene therapy for cholesterol (1994) (36)
The Experience of Insight: A Simple and Direct Guide to Buddhist Meditation (1983) (35)
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region. (1986) (35)
Atherosclerosis. Scavenging for receptors. (1990) (34)
Purification of the LDL receptor. (1985) (34)
Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo. (1984) (34)
Why Is It So Hard to Pay Attention, or Is It? Mindfulness, the Factors of Awakening and Reward-Based Learning (2013) (34)
Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study. (1979) (34)
Expression of two X-linked genes in human hair follicles of double heterozygotes. (1971) (34)
Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein. (1982) (34)
Genetics of hyperlipidemia in coronary heart disease. (1972) (33)
Genetic and hormonal control of male sexual differentiation (1975) (32)
Purification of ras farnesyl:Protein transferase (1990) (32)
Development of increased cytoplasmic binding of androgen in the submandibular gland of the mouse with testicular feminization. (1973) (32)
Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis. (1988) (32)
From fatty streak to fatty liver: 33 years of joint publications in the JCI. (2008) (32)
Classification of hereditary disorders of sexual development. (1975) (30)
Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads. (1977) (30)
What Makes a Piece of Art or Science a Masterpiece? (2018) (30)
A Golden Era of Nobel Laureates (2012) (29)
Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. (1995) (29)
Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay. (1989) (29)
For Harold Lasswell: Some Reflections on Human Dignity, Entrapment, Informed Consent, and the Plea Bargain (1975) (29)
A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase. (1991) (29)
In this very life : the liberation teachings of the Buddha (1992) (29)
Isoform 1 c of Sterol Regulatory Element Binding Protein Is Less Active Than Isoform 1 a in Livers of Transgenic Mice and in Cultured Cells (2013) (28)
Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis (2017) (28)
Familial hypercholesterolemia: model for genetic receptor disease. (1979) (28)
Atherosclerosis: Scavenger cell receptor shared (1985) (27)
reply: Leptin and diabetes in lipoatrophic mice (2000) (27)
Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice (2019) (27)
3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. (1975) (27)
Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice. (1979) (26)
Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi* (2013) (25)
PATHWAY AND ITS RELATION TO ATHEROSCLEROSISl (1977) (25)
Homocystinuria: heterozygote detection using phytohemagglutinin-stimulated lymphocytes. (1973) (24)
Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters. (1987) (24)
The Government of British Trade Unions. (1953) (24)
ABOLISH THE INSANITY DEFENSE--WHY NOT? (1964) (24)
Laskers for 2001: Knockout mice and test-tube babies (2001) (24)
cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (1993) (24)
The low density lipoprotein pathway in human fibroblasts (1976) (22)
Seventeenth Marabou Symposium on Diet and Genetic Interactions: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake (1998) (21)
Scavenger cell receptor shared. (1985) (21)
DANGEROUSNESS AND MENTAL ILLNESS Some Observations on the Decision to Release Persons Acquitted by Reason of Insanity (1960) (20)
The low density lipoprotein receptor in Xenopus laevis. II. Feedback repression mediated by conserved sterol regulatory element. (1991) (19)
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1 (2018) (18)
Protein prenylation. Mad bet for Rab. (1993) (18)
The Family and the Law (1966) (18)
Complementation Cloning of S 2 P , a Gene Encoding a Putative Metalloprotease Required for Intramembrane (1997) (17)
Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy. (1980) (16)
Abolish the "Insanity Defense". Why Not? (1963) (16)
Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells. (1977) (16)
Similar content of phospholipids and gangliosides in normal and homozygous familial hypercholesterolemia fibroblasts. (1978) (16)
Direct Demonstration That Loop1 of Scap Binds to Loop7 (2016) (15)
How a jolt and a bolt in a dentist's chair revolutionized cataract surgery (2004) (15)
BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver (2018) (15)
Lipoprotein receptors: therapeutic implications (1990) (14)
Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine. (1996) (14)
Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo. (1981) (14)
Preparation and spectral properties of lipophilic fluorescein derivatives: Application to plasma low-density lipoprotein (1981) (14)
Thinking About Public Policy Toward Abuse and Neglect of Children: A Review of Before the Best Interests of the Child (1980) (13)
beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism. (1980) (13)
Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA. (1982) (13)
Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein. (1987) (13)
Psychoanalysis and Jurisprudence (1968) (13)
RECEPTOR-MEDIATED UPTAKE OF MACROMOLECULES AND THEIR DELIVERY TO LYSOSOMES IN HUMAN FIBROBLASTS (1978) (13)
Role of the LDL Receptor in the Regulation of Cholesterol and Lipoprotein Metabolism (1976) (13)
Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide. (2002) (13)
Biosynthesis of Cholesterol in Familial Hypercholesterolaemic Xanthomatosis (1959) (12)
Psychoanalysis, Psychiatry, And Law (1967) (12)
Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol (2022) (12)
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing (2021) (12)
Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells. (1995) (12)
Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia. (1982) (11)
The government of a British trade union : a study of apathy and the democratic process in the Transport and General Workers Union (1952) (11)
Genetic aspects of hyperlipidemia in coronary heart disease (1973) (11)
Leptin and diabetes in lipoatrophic mice. Authors' reply (2000) (10)
Lipoprotein receptors and the genetic control of cholesterol metabolism in cultured human cells (1975) (9)
Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man. (1974) (9)
Regulated Intramembrane Proteolysis : Review A Control Mechanism Conserved from Bacteria to Humans (2000) (9)
The Spanish 1918 Flu and the COVID-19 Disease: The Art of Remembering and Foreshadowing Pandemics (2020) (9)
Creation and revelation: two different routes to advancement in the biomedical sciences (2007) (8)
Science Over Politics (1999) (8)
The isolation of gamma-globulins from rat, guinea pig, and rabbit plasma. (1957) (7)
Prolonged hypouricemia associated with acute chlorprothixene ingestion. (1975) (7)
Homozygous familial hypercholesterolemia (receptor-negative type). Repository identification No. GM-361. (1975) (7)
The Intelligible Constitution: The Supreme Court's Obligation to Maintain the Constitution as Something We the People Can Understand (1992) (7)
A Heart Full of Peace (2007) (7)
TAKING THE PEOPLE SERIOUSLY (2010) (7)
Scientific Side Trips: Six Excursions from the Beaten Path (2012) (6)
Atherosclerosis and its complications: contributions from the Association of American Physicians, 1886-1986. (1986) (6)
Balanced anesthesia: low-dose ketamine/neuroleptanalgesia (1986) (6)
Emerging Themes in Biology: Hints for the Future (2014) (6)
New directions in human biochemical genetics: understanding the manifestations of receptor deficiency states. (1976) (5)
The family and the law : problems for decision in the family law process (1965) (5)
In the best interests of the child : professional boundaries (1986) (5)
"Put yourself in the skin of the child," she said. (1996) (5)
PICTORIAL ILLUSTRATIONS OF THE RECEPTOR-MEDIATED ENDOCYTOSIS OF LOW DENSITY LIPOPROTEIN VIA COATED REGIONS OF MEMBRANE (1981) (5)
The amino acid sequence around the "reactive sulfhydryl" group of the beta chain from human hemoglobin. (1961) (5)
Finding the Least Detrimental Alternative (1974) (5)
p21ras farnesyltransferase: purification and properties of the enzyme. (1992) (5)
Diet-induced hypercholesterolemia in mice (1990) (5)
Foreword: Towering science: an ounce of creativity is worth a ton of impact (2004) (5)
Suppression of 3 hydroxy 3 methylglutaryl coenzyme A reductase in familial hypercholesterolemia fibroblasts by cholesterol analogues (1974) (4)
The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking (2010) (4)
Criminal Law: Theory and Process (1974) (4)
Jewish history in modern times (1995) (4)
The Government of a British Trade Union. (1954) (4)
Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts. (1975) (4)
A case of genital self-amputation in which reconstruction was proposed. (1990) (4)
ORGANIZATIONAL STRESS IN THE ROLE OF THE ELEMENTARY SCHOOL PRINCIPAL IN ISRAEL (1981) (4)
Why foster care--for whom for how long? (1975) (4)
On the function of criminal law in riot control. (1969) (4)
Lowering plasma cholesterol by raising ldl receptors. 1981. (2004) (4)
Paradigm shifts in science: insights from the arts (2012) (4)
Richard G.W. Anderson (1940–2011) and the birth of receptor-mediated endocytosis (2011) (3)
Starting out as a physician-scientist: the crucial first step on the ladder to success. (2017) (3)
Crime, law, and society (1971) (3)
Psychoanalysis and a jurisprudence of child placement--with special emphasis on the role of legal counsel for children. (1978) (3)
Familial hypercholesterolemia: unraveling a genetic receptor disease. (1977) (3)
Golgi : Insig renders sorting signal in Scap inaccessible to COPII proteins From the Cover : Sterol-regulated transport of SREBPs from endoplasmic reticulum to (2007) (3)
Point Mutation in Luminal Loop 7 of Scap Blocks Interaction with Loop 1 and Abolishes Movement to Golgi * (2013) (3)
1 IDENTIFICATION OF LUMINAL LOOP 1 OF SCAP AS THE STEROL SENSOR THAT MAINTAINS CHOLESTEROL HOMEOSTASIS (2011) (3)
Receptor-mediated endocytosis and the structural organization of the cell membrane. (1982) (3)
Author response: Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection (2015) (3)
Cell Metabolism: Why, and why now? (2005) (3)
Extracellular domain of the LDL receptor (2003) (2)
Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17a-ethinyl estradiol (SI nuclease assay/regulation of cell surface receptors/cholesterol metabolism) (2016) (2)
Unexpected role for IGF-1 in starvation: Maintenance of blood glucose (2022) (2)
Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002. (2002) (2)
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a potential step in cholesterol egress from lysosomes.* (2009) (2)
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins ( fl-very low density lipoproteins / chylomicrons / familial hypercholesterolemia / cell-surface receptors / lysosomal hydrolysis ) (2)
Familial pseudomembranous colitis and its relation to lincomycin therapy (1975) (2)
Regulated Intramembrane Proteolysis (Rip) (2004) (2)
Criminal Law: Problems for Decision in the Promulgation, Invocation and Administration of a Law of Crimes. (1962) (2)
The Brawner Rule—Why? or No More Nonsense on Non Sense in the Criminal Law, Please! (1973) (2)
精神分析学と法学(Psychoanalysis and Jurisprudence,77.Yale L.J.1053(1968)) (1973) (2)
Beyond Any Discipline's Competence (1974) (2)
THE ELEMENTARY SCHOOL PRINCIPALSHIP IN ISRAEL (1975) (2)
Psychoanalysis and jurisprudence: on the relevance of psychoanalytic therapy to law. (1968) (2)
Burgers, Chips, and Genes (1999) (2)
Venture science: climbing the ladder to telomerase, cognitive therapy and in situ hybridization (2006) (2)
Juxtapositions in Trafalgar Square: tip-offs to creativity in art and science (2013) (2)
Balzac's Unknown Masterpiece: spotting the next big thing in art and science (2014) (2)
Seurat’s Dots: A Shot Heard ’Round the Art World—Fired by an Artist, Inspired by a Scientist (2019) (2)
Presentation of the Kober Medal (2010) (2)
The Opinion-Writing Function of the Judiciary of Latin American Governments in Transition to Democracy: Martinez v. Provincia de Mendoza (2019) (1)
Familial Hypercholesterolemia in a Large Kindred (2020) (1)
Recent advances in genetic counseling (1976) (1)
How to win a Lasker? Take a close look at Bathers and Bulls (2010) (1)
The art and science of building castles in the sky and houses of cards that don’t collapse (2022) (1)
The Slow-Down, An Unprotected Concerted Activity—A Pyrrhic Victory for Management (1951) (1)
Artists Create Puzzles, Scientists Solve Them (2017) (1)
Exuberant unpredictability: sine qua non for priceless and prizeworthy biomedical research (2008) (1)
A Case Study of an In-Service Training Program for Israeli Principals. (1980) (1)
Foreword: It's a grand year for celebrating science (2003) (1)
Molecular Characterization of Human Acetyl CoA Synthetase, an Enzyme Regulated by SREBPs * (2000) (1)
SREBPs: Activators of cholesterol and monounsaturated fatty acid synthesis (1999) (1)
Government Bid Protests (2000) (1)
A Well-Hung Horse: Sired by Knowledge and Imagination (2015) (1)
Peptidomimetic inhibitors of Ras farnesylation (1994) (1)
Not for the Law to Approve or Disapprove—A Comment on Professor Mnookin’s Paper (1984) (1)
Recurring Origins ofAllopolyploid Species inAsplenium (1985) (1)
Human mutations affecting the low density lipoprotein pathway. (1977) (1)
Regulation of low density lipoprotein receptor gene expression in HepG 2 and Caco 2 cells by palmitate , oleate , and 25-hydroxycholestero 11 Rai (2002) (1)
The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon (2016) (1)
Lasker Awards and papal portraiture: turning fields upside down (2009) (1)
Interview with Joseph Goldstein (2001) (1)
Anna Freud in law. (1984) (1)
Criminal Law: Problems for Decision in the Promulgation, Invocation, and Administration of a Law of Crimes (1963) (1)
LDL Receptor Mutations in Patients with Familial Hypercholesterolemia (1987) (1)
Hyperlipidemia in Survivors of Myocardial Infarction: Relationship between Genetic Classification and Lipoprotein Phenotype (1974) (1)
The Government of British Trade Unions@@@Union Solidarity (1952) (0)
Israel (1982) (0)
Resistance of K-RasBVl 2 proteins to farnesyltransferase inhibitors in Ratl cells ( protein prenylation / geranylgeranyl transferase I / transformed cells / benzodiazepine-5 B / L-739 , 749 ) (2005) (0)
Geranylgeranylated Rabproteins terminating inCys-Ala-Cys, but notCys-Cys, arecarboxyl-methyla (1994) (0)
Mutational Analysis of a Menabrane Protein (1990) (0)
The genetic basis of hypercholesterolemia: clinical and therapeutic implications. (1992) (0)
PlasmaLipidLevels andCoronary HeartDisease inAdult Relatives ofNewbornswithNormaland Elevated CordBloodLipids (1974) (0)
The Care and Feeding of the United States Constitution (1993) (0)
Jabotinsky and Jewish autonomy in the Diaspora (1986) (0)
Lipoprotein receptors : therapeutic implications. Discussion (1990) (0)
Sequencing the human genome: implications for clinical medicine (1989) (0)
Cystathionine synthase activity in human leukocyte cultures. (1973) (0)
Genetic Heterogeneity in Familial Hyperc Different Mutations Affecting Functions o (cholesterol metabolism/atherosclerosis/hyperlipidemia/l (2016) (0)
Biosynthesis and processing of normal and mutant receptors for low density lipoprotein (1988) (0)
Hyperlipidemia inCoronary Heart Disease III.EVALUATION OF LIPOPROTEINPHENOTYPES OF 156 GENETICALLY DEFINED SURVIVORSOF MYOCARDIAL INFARCTION (1973) (0)
Transgenic mice: A new approach to lipoprotein metabolism and atherogenesis (1992) (0)
The 1985 Nobel Prize Fu Medichse— Have Revolutionized Our Knowledge about Cholesterol Metabolisms and Heart Disease --- Number 38 (1986) (0)
Human mutations affecting the low density lipoprotein pathway. (1977) (0)
Optimum statistical communication models of the human senses (1982) (0)
Secondary amyloidosis: from an abstruse pathologic curiosity to a treatable molecular disease (1983) (0)
Insulin Receptor Substrate-l ( IRS-l ) Expression in Rat Brain (2001) (0)
The ldl receptor supergene family (1992) (0)
The Calyx, 1962 (yearbook) (1962) (0)
Letter from Joseph L. Goldstein to Victor A. McKusick (1971) (0)
Psycholanalysis, Psychiatry and Law (1968) (0)
Foreword: Synergy and symbiosis à la Matisse-Picasso (2002) (0)
Data on cytogenetic registers (1976) (0)
RECEPTOR-MEDIATED ENDOCYTOSIS AS EXEMPLIFIED BY THE LOW DENSITY LIPOPROTEIN RECEPTOR (1983) (0)
Safeguards for the Rights of Patient and Doctor Under a National Health Program—The British National Health Service Act of 1946 (1951) (0)
Low density lipoprotein receptor knockout mouse (1994) (0)
The 2020 Lasker Awards and the COVID-19 Pandemic. (2020) (0)
New BME Chairman Acts to Lead Strong Department into International Leadership Role (2002) (0)
Influence of Methanolic Extractives of Leaves of Mulberry, Morus alba (L) on the Hypercholesterolemia in Rat, Rattus norvegicus (L). (2019) (0)
60 years of winged victories for biomedical research (2005) (0)
Saturation andsuppression ofhepatic lipoprotein receptors: A mechanism forthehypercholesterol (1981) (0)
1SY01-4 Activators or inhibitors of SREBPs for the treatment of hypercholesterolemia (2003) (0)
How a jolt and a bolt in a dentist’s chair revolutionized cataract surgery (2005) (0)
Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar. (1999) (0)
The card players of Caravaggio, Cézanne and Mark Twain: tips for getting lucky in high-stakes research (2011) (0)
The surprise element: A hallmark of creativity in scientists, artists, and comedians (2021) (0)
By sterols regulated promoter elements. (1988) (0)
Cellular uptake of lipoproteins through LRP is apo e dependent (1990) (0)
Round-Table - the Human Genome Project (1993) (0)
Methods and reagents for the identification, characterization and inhibition of farnesyl-protein transferase. (1991) (0)
The AAMC Award for Distinguished Research in the Biomedical Sciences. (1983) (0)
New insights into cellular cholesterol homeostasis (1997) (0)
Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA (1985) (0)
Familial Hypercholesterolemia: Defective Cultured Fibroblasts Associated with Imp 3-Hydroxy-3-Methylglutaryl Coenzyme A (cholesterol synthesis/hyperlipidemia/atheroselerosis/en: (2016) (0)
Why Is It So Hard to Pay Attention, or Is It? Mindfulness, the Factors of Awakening and Reward-Based Learning (2012) (0)
The Ldl Receptor: Functional Studies And Partial Characterization (1984) (0)
LIPOPROTEIN METABOLISM I\ TI IF \1AC:ROPIIAGE: Implications for Cholesterol Deposition in Atherosclerosis' (2007) (0)
Biochemical and Morphologic Correlations (2003) (0)
Monoclonal Antibody as a Probe for Structural and Functional Studies of the LDL Receptor (1983) (0)
Hypercholesterolemia inLowDensity Lipoprotein Receptor Knockout MiceanditsReversal byAdenovirus-mediated GeneDelivery (1993) (0)
Profiles in Cardiovascular Science (2010) (0)
Author response: Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1 (2018) (0)
Elements regulateurs de sterol (1988) (0)
Presentation of the Kober Medal Presentation of the Kober Medal to (2010) (0)
Receptor-mediated endocytosis : Insights from the lipoprotein receptor system * ( lysosomes / coated pits and vesicles / cholesterol / familial hypercholesterolemia / hormone action ) (0)
Workshop: Types and Genetics of Hyperlipoproteinemias (1974) (0)
Erythropoietin mimetic peptides and the future (2000) (0)
Author response: BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver (2018) (0)
WT Chicken Scap L1-L7 / Fab 4G10 complex focused refinement (2021) (0)
Disruption of the LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia and atherosclerosis resulting from the production of lipid-rich VLDL (1999) (0)
Selective killing of cultured cells by receptor-dependent photosensitization (1981) (0)
Tumor necrosis factor: biotechnology's answer to cancer? (1985) (0)
Foreword: Simplifying Cholesterol Metabolism (1990) (0)
Tetrapeptides Compete with p21(ras) for Farnesylation Catalyzed by Protein Farnesyltransferase (1992) (0)
The Silent World of Collaborators from Different Disciplines (1988) (0)
Method and zusammemsetzungen similar to the binding protein of the sterol regulatory element (1994) (0)
Democracy and Dishonesty (1993) (0)
1-1-1968 Psychoanalysis and Jurisprudence (2013) (0)
Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar. (1999) (0)
Letting Children Decide (1981) (0)
SREPBs: Gene Regulation through Controlled Protein Trafficking (2003) (0)
The ghrelin-growth hormone axis preserves gluconeogenesis to maintain blood glucose levels during starvation (2012) (0)
Tribute to Dr. Akira Endo (2018) (0)
On Abolition of Grounds for Divorce: A Model Statute & Commentary (1969) (0)
Criminal law : problems for decision in the promulgation, invocation and administration of a law of crimes (1963) (0)
Co-localization of t 2 l-Epidermal Growth Factor and Ferritin-low Density Lipoprotein in Coated Pits : A Quantitative Electron Microscopic Study in Normal Mutant Human Fibroblasts and (2003) (0)

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