Judith Klinman
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American chemist
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Judith Klinmanchemistry Degrees
Chemistry
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#1731
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Physical Chemistry
#268
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#312
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Chemistry
Judith Klinman's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of Pennsylvania
Why Is Judith Klinman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Judith P. Klinman is an American chemist, biochemist, and molecular biologist known for her work on enzyme catalysis. She became the first female professor in the physical sciences at the University of California, Berkeley in 1978, where she is now Professor of the Graduate School and Chancellor's Professor. In 2012, she was awarded the National Medal of Science by President Barack Obama. She is a member of the National Academy of Sciences, American Academy of Arts and Sciences, American Association for the Advancement of Science, and the American Philosophical Society.
Judith Klinman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. (2013) (1360)
- Mechanisms Whereby Mononuclear Copper Proteins Functionalize Organic Substrates. (1996) (620)
- A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. (1990) (551)
- Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase (1999) (423)
- Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics. (2002) (365)
- Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments (2019) (327)
- A Crosslinked Cofactor in Lysyl Oxidase: Redox Function for Amino Acid Side Chains (1996) (298)
- Tunneling and dynamics in enzymatic hydride transfer. (2006) (268)
- The Copper-Enzyme Family of Dopamine β-Monooxygenase and Peptidylglycine α-Hydroxylating Monooxygenase: Resolving the Chemical Pathway for Substrate Hydroxylation* (2006) (262)
- Quinoenzymes in biology. (1994) (255)
- A 21st century revisionist's view at a turning point in enzymology. (2009) (251)
- Hydrogen tunneling links protein dynamics to enzyme catalysis. (2013) (245)
- Enzyme Catalysis: Beyond Classical Paradigms† (1998) (239)
- Hydrogen-Transfer Reactions (2006) (224)
- Environmentally coupled hydrogen tunneling (2002) (217)
- Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and function. (1988) (183)
- Hydrogen tunneling in biology. (1999) (181)
- Catalytic mechanism of the topa quinone containing copper amine oxidases. (2002) (179)
- Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase (2002) (159)
- Identification of topaquinone and its consensus sequence in copper amine oxidases. (1992) (142)
- Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. (1999) (142)
- Intrigues and intricacies of the biosynthetic pathways for the enzymatic quinocofactors: PQQ, TTQ, CTQ, TPQ, and LTQ. (2014) (139)
- A link between protein structure and enzyme catalyzed hydrogen tunneling. (1997) (137)
- Climate change and the integrity of science. (2010) (137)
- Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1 (2008) (137)
- How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase (2015) (136)
- How do enzymes activate oxygen without inactivating themselves? (2007) (131)
- Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation. (1998) (125)
- Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species. (2003) (121)
- Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. (2004) (119)
- Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. (1995) (114)
- Experimental Evidence for Extensive Tunneling of Hydrogen in the Lipoxygenase Reaction: Implications for Enzyme Catalysis (1996) (114)
- Kinetic studies of oxygen reactivity in soybean lipoxygenase-1. (2003) (107)
- An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling. (2009) (106)
- Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases. (1992) (105)
- Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. (1993) (104)
- Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. (2010) (104)
- Distribution and properties of the genes encoding the biosynthesis of the bacterial cofactor, pyrroloquinoline quinone. (2012) (101)
- Hydrogen Tunneling in Peptidylglycine α-Hydroxylating Monooxygenase (2002) (101)
- Probing the mechanism of proton coupled electron transfer to dioxygen: the oxidative half-reaction of bovine serum amine oxidase. (1998) (98)
- Extremely Large Isotope Effects in the Soybean Lipoxygenase-Linoleic Acid Reaction (1994) (97)
- Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. (1996) (96)
- Primary structures for a mammalian cellular and serum copper amine oxidase. (1994) (96)
- Evidence of a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase. (1994) (94)
- Evidence that both protium and deuterium undergo significant tunneling in the reaction catalyzed by bovine serum amine oxidase. (1989) (93)
- Steric control of oxygenation regiochemistry in soybean lipoxygenase-1. (2001) (93)
- Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase. (2004) (90)
- Oxygen-18 kinetic isotope effects in the dopamine beta-monooxygenase reaction: evidence for a new chemical mechanism in non-heme metallomonooxygenases. (1994) (88)
- Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme. (2009) (84)
- An investigation of bovine serum amine oxidase active site stoichiometry: evidence for an aminotransferase mechanism involving two carbonyl cofactors per enzyme dimer. (1991) (83)
- The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide-dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction. (1972) (83)
- Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction. (1997) (81)
- Structure-function studies of substrate oxidation by bovine serum amine oxidase: relationship to cofactor structure and mechanism. (1991) (80)
- Synthesis and spectroscopic characterization of model compounds for the active site cofactor in copper amine oxidases (1993) (80)
- Structural bases of hydrogen tunneling in enzymes: progress and puzzles. (2004) (79)
- Isotope effects and structure-reactivity correlations in the yeast alcohol dehydrogenase reaction. A study of the enzyme-catalyzed oxidation of aromatic alcohols. (1976) (79)
- Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. (2004) (79)
- Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics. (2002) (78)
- Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency. (2011) (78)
- The multi-functional topa-quinone copper amine oxidases. (2003) (78)
- Model Studies of Topaquinone-Dependent Amine Oxidases. 1. Oxidation of Benzylamine by Topaquinone Analogs (1995) (77)
- Copper amine oxidase: heterologous expression, purification, and characterization of an active enzyme in Saccharomyces cerevisiae. (1994) (77)
- Model Studies of Topaquinone-Dependent Amine Oxidases. 2. Characterization of Reaction Intermediates and Mechanism (1995) (77)
- New Quinocofactors in Eukaryotes* (1996) (75)
- The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase (2008) (74)
- Probes of mechanism and transition-state structure in the alcohol dehydrogenase reaction. (1981) (74)
- Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction. (1998) (72)
- Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase* (2007) (72)
- Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD*♦ (2016) (71)
- Nature of oxygen activation in glucose oxidase from Aspergillus niger: the importance of electrostatic stabilization in superoxide formation. (1999) (70)
- Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H Activation (2014) (70)
- Dynamically Achieved Active Site Precision in Enzyme Catalysis (2014) (69)
- Hydrogen tunneling in the flavoenzyme monoamine oxidase B. (1994) (69)
- Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling (2006) (66)
- Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects. (2018) (66)
- Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. (2004) (65)
- Protein Flexibility Correlates with Degree of Hydrogen Tunneling in Thermophilic and Mesophilic Alcohol Dehydrogenases (2000) (64)
- Mediation of donor–acceptor distance in an enzymatic methyl transfer reaction (2015) (64)
- PqqD Is a Novel Peptide Chaperone That Forms a Ternary Complex with the Radical S-Adenosylmethionine Protein PqqE in the Pyrroloquinoline Quinone Biosynthetic Pathway* (2015) (64)
- Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance. (2005) (63)
- The organic functional group in copper-containing amine oxidases. Resonance Raman spectra are consistent with the presence of topa quinone (6-hydroxydopa quinone) in the active site. (1991) (62)
- Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors (2011) (60)
- An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha. (1999) (60)
- Mechanism of modulation of dopamine beta-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies. (1983) (59)
- [14] Hydrogen tunneling in enzyme catalysis (1995) (58)
- Galactose oxidase as a model for reactivity at a copper superoxide center. (2009) (58)
- Evidence for two copper atoms/subunit in dopamine beta-monooxygenase catalysis. (1984) (58)
- The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast. (2001) (58)
- Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue. (2004) (57)
- Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover. (2005) (55)
- The role of tunneling in enzyme catalysis of C-H activation. (2006) (55)
- Life as aerobes: are there simple rules for activation of dioxygen by enzymes? (2000) (54)
- Correlation of copper valency with product formation in single turnovers of dopamine beta-monooxygenase. (1989) (52)
- Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects. (1980) (52)
- Structure of bovine adrenal dopamine beta-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide. (1989) (52)
- Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions (1985) (51)
- Importance of protein dynamics during enzymatic C-H bond cleavage catalysis. (2013) (51)
- Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast. (2000) (51)
- Evidence Against Reduction of Cu2+ to Cu+ during Dioxygen Activation in a Copper Amine Oxidase from Yeast (2000) (50)
- Spectroscopic detection of chemical intermediates in the reaction of para-substituted benzylamines with bovine serum amine oxidase. (1993) (50)
- Characterization of the Native Lysine Tyrosylquinone Cofactor in Lysyl Oxidase by Raman Spectroscopy* (1997) (49)
- The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis. (2004) (49)
- Evolutionary Aspects of Enzyme Dynamics* (2014) (48)
- Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase. (2004) (48)
- 18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates. (2008) (48)
- Kinetic analysis of oxygen utilization during cofactor biogenesis in a copper-containing amine oxidase from yeast. (2000) (47)
- Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. (1998) (47)
- Oxygen-18 kinetic isotope effect studies of the tyrosine hydroxylase reaction: Evidence of rate limiting oxygen activation (1998) (46)
- Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications. (2003) (46)
- Computational Study of Tunneling and Coupled Motion in Alcohol Dehydrogenase-Catalyzed Reactions: Implication for Measured Hydrogen and Carbon Isotope Effects (1999) (46)
- Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase. (2003) (45)
- Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling (2017) (44)
- Reductive trapping of substrate to bovine plasma amine oxidase. (1987) (44)
- Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase. (1980) (44)
- Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily. (2010) (43)
- 13C ENDOR Spectroscopy of Lipoxygenase–Substrate Complexes Reveals the Structural Basis for C–H Activation by Tunneling (2017) (43)
- Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs. (2017) (43)
- The Catalytic Function of Bovine Lysyl Oxidase in the Absence of Copper* (2001) (42)
- Characterization of alternate reductant binding and electron transfer in the dopamine beta-monooxygenase reaction. (1987) (41)
- Isotopic probes yield microscopic constants: separation of binding energy from catalytic efficiency in the bovine plasma amine oxidase reaction. (1983) (41)
- pH dependence of deuterium isotope effects and tritium exchange in the bovine plasma amine oxidase reaction: a role for single-base catalysis in amine oxidation and imine exchange. (1986) (40)
- Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases. (2004) (40)
- Implication for Functions of the Ectopic Adipocyte Copper Amine Oxidase (AOC3) from Purified Enzyme and Cell-Based Kinetic Studies (2012) (40)
- Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models (2017) (39)
- Discrimination between 16O and 18O in oxygen binding to the reversible oxygen carriers hemoglobin, myoglobin, hemerythrin, and hemocyanin: a new probe for oxygen binding and reductive activation by proteins (1993) (38)
- Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures. (2001) (38)
- Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. (2012) (37)
- Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency (2010) (37)
- Mechanistic comparison of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha. (2002) (36)
- Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. (2005) (36)
- Kinetic and structural analysis of substrate specificity in two copper amine oxidases from Hansenula polymorpha. (2010) (36)
- Steady-state kinetic investigation of cytochrome P450cam: interaction with redox partners and reaction with molecular oxygen. (2004) (35)
- Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling. (2002) (35)
- Dynamic barriers and tunneling. New views of hydrogen transfer in enzyme reactions (2003) (35)
- A new model for the origin of kinetic hydrogen isotope effects (2010) (35)
- Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase. (2001) (34)
- The zinc content of yeast alcohol dehydrogenase. (1976) (34)
- Identification of a Long-range Protein Network That Modulates Active Site Dynamics in Extremophilic Alcohol Dehydrogenases* (2013) (34)
- Binding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha. (2002) (34)
- Rapid freeze- and chemical-quench studies of dopamine beta-monooxygenase: comparison of pre-steady-state and steady-state parameters. (1989) (34)
- Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen. (2011) (34)
- Multistep, eight-electron oxidation catalyzed by the cofactorless oxidase, PqqC: identification of chemical intermediates and their dependence on molecular oxygen. (2013) (33)
- Role of internal thermodynamics in determining hydrogen tunneling in enzyme-catalyzed hydrogen transfer reactions. (1992) (33)
- The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation. (2006) (33)
- Stereochemistry and kinetic isotope effects in the bovine plasma amine oxidase catalyzed oxidation of dopamine. (1979) (32)
- Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone. (2017) (32)
- Modular behavior of tauD provides insight into the origin of specificity in α-ketoglutarate-dependent nonheme iron oxygenases (2009) (31)
- Mutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase. (1999) (31)
- Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli. (2000) (31)
- Effect of Metal on 2,4,5-Trihydroxyphenylalanine (Topa) Quinone Biogenesis in the Hansenula polymorpha Copper Amine Oxidase* (1997) (30)
- Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity. (2008) (30)
- Oxygen Kinetic Isotope Effects in Soluble Methane Monooxygenase* (2001) (30)
- Status of the cofactor identity in copper oxidative enzymes (1991) (30)
- Acid-base catalysis in the yeast alcohol dehydrogenase reaction. (1975) (30)
- Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy. (1995) (29)
- Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase. (2001) (29)
- Pyrroloquinoline quinone: a new redox cofactor in eukaryotic enzymes. (1988) (29)
- Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein (2011) (28)
- Enzyme Catalysis: Beyond Classical Paradigms (1998) (28)
- Quantum mechanical effects in enzyme-catalysed hydrogen transfer reactions. (1989) (27)
- Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway. (2019) (27)
- Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species (2015) (27)
- The copper centers of tyramine β-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study (2010) (26)
- Evidence That Dioxygen and Substrate Activation Are Tightly Coupled in Dopamine β-Monooxygenase (2003) (26)
- How many ways to craft a cofactor? (2001) (26)
- Mechanism of the Insect Enzyme, Tyramine β-Monooxygenase, Reveals Differences from the Mammalian Enzyme, Dopamine β-Monooxygenase* (2008) (25)
- Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase. (1971) (25)
- X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE. (2018) (25)
- Purification and kinetic properties of aconitate isomerase from Pseudomonas putida. (1971) (25)
- An active-site phenylalanine directs substrate binding and C-H cleavage in the alpha-ketoglutarate-dependent dioxygenase TauD. (2010) (25)
- Topaquinone-dependent amine oxidases: identification of reaction intermediates by Raman spectroscopy. (1997) (25)
- Control of the Position of Oxygen Delivery in Soybean Lipoxygenase-1 by Amino Acid Side Chains within a Gas Migration Channel* (2016) (24)
- Partial conversion of Hansenula polymorpha amine oxidase into a "plant" amine oxidase: implications for copper chemistry and mechanism. (2007) (24)
- Pathway for the Stereocontrolled Z and E Production of α,α-Difluorine-Substituted Phenyl Butenoates (2006) (24)
- Identification of the quinone cofactor in a lysyl oxidase from Pichia pastoris (1996) (23)
- Dopamine beta-hydroxylase: activity and inhibition in the presence of beta-substituted phenethylamines. (1982) (23)
- 2,4,5-Trihydroxyphenylalanine quinone biogenesis in the copper amine oxidase from Hansenula polymorpha with the alternate metal nickel. (2005) (23)
- De novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note. (2003) (22)
- Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast. (1998) (22)
- Pyrroloquinoline quinone biogenesis: characterization of PqqC and its H84N and H84A active site variants. (2007) (22)
- Cooperativity in the dopamine beta-monooxygenase reaction. Evidence for ascorbate regulation of enzyme activity. (1991) (22)
- The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: a kinetic study of the H172A mutant. (2006) (22)
- Hydroxylase activity of Met471Cys tyramine beta-monooxygenase. (2008) (22)
- Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction. (2000) (21)
- Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase (2016) (21)
- Mechanism of the aconitate isomerase reaction. (1971) (20)
- Cloning and characterization of histamine dehydrogenase from Nocardioides simplex. (2005) (20)
- Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates. (2006) (20)
- Stereochemical probes of bovine plasma amine oxidase: evidence for mirror image processing and a syn abstraction of hydrogens from C-1 and C-2 of dopamine. (1986) (20)
- Hydrogen Tunneling in a Prokaryotic Lipoxygenase (2014) (20)
- Activity-Related Microsecond Dynamics Revealed by Temperature-Jump Förster Resonance Energy Transfer Measurements on Thermophilic Alcohol Dehydrogenase. (2018) (20)
- Picosecond-Resolved Fluorescent Probes at Functionally Distinct Tryptophans within a Thermophilic Alcohol Dehydrogenase: Relationship of Temperature-Dependent Changes in Fluorescence to Catalysis (2014) (20)
- Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics. (2006) (20)
- Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine β-monooxygenase. (2013) (19)
- Enzyme dynamics: Control of active-site compression. (2010) (19)
- Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase. (2019) (19)
- Role of a strictly conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha. (2006) (19)
- Mechanism-based inactivation of a yeast methylamine oxidase mutant: implications for the functional role of the consensus sequence surrounding topaquinone. (1997) (18)
- Dynamics in Enzyme Catalysis (2013) (18)
- The power of integrating kinetic isotope effects into the formalism of the Michaelis–Menten equation (2014) (18)
- Stereochemistry and kinetic isotope effects in the decarboxylation of S-adenosylmethionine catalyzed by the pyruvyl enzyme, S-adenosylmethionine decarboxylase. (1981) (18)
- Hydrogen–deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase (2017) (18)
- Relationship of stopped flow to steady state parameters in the dimeric copper amine oxidase from Hansenula polymorpha and the role of zinc in inhibiting activity at alternate copper-containing subunits. (2006) (17)
- Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase (2015) (17)
- Hydrogen tunneling in enzyme catalysis. (1995) (17)
- The magnitude of enzyme transition state analog binding constants. (1974) (16)
- Whence topa? Models for the biogenesis of topa quinone in copper amine oxidases (2000) (15)
- A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone (2019) (15)
- Picosecond-Resolved Fluorescence Studies of Substrate and Cofactor-Binding Domain Mutants in a Thermophilic Alcohol Dehydrogenase Uncover an Extended Network of Communication (2014) (15)
- The nature of O2 reactivity leading to topa quinone in the copper amine oxidase from Hansenula polymorpha and its relationship to catalytic turnover. (2005) (15)
- Comparative Study of 17O and 18O Isotope Effects As a Probe for Dioxygen Activation: Application to the Soybean Lipoxygenase Reaction# (1997) (15)
- esized and post-translationally modi fi ed peptide natural products : overview and recommendations for a universal nomenclature (2012) (15)
- Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) (2013) (15)
- Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol. (1988) (15)
- Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts. (1987) (15)
- Isolation of 2,4,5-trihydroxyphenylalanine quinone (topa quinone) from copper amine oxidases. (1995) (15)
- Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine. (1984) (14)
- Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase. (2002) (14)
- Reductive trapping of substrate to methylamine oxidase from Arthrobacter P1 (1990) (14)
- Nature of rate-limiting steps in a compartmentalized enzyme system. Quantitation of dopamine transport and hydroxylation rates in resealed chromaffin granule ghosts. (1989) (14)
- Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. (2019) (14)
- The interaction of an epoxide with yeast alcohol dehydrogenase: evidence for binding and the modification of two active site cysteines by styrene oxide. (1975) (14)
- Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity. (2010) (14)
- Activity of membranous dopamine beta-monooxygenase within chromaffin granule ghosts. Interaction with ascorbate. (1991) (14)
- Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C-H Activation by Soybean Lipoxygenase-1. (2016) (14)
- Structural Snapshots from the Oxidative Half-reaction of a Copper Amine Oxidase (2013) (14)
- Characterization of a protein-generated O₂ binding pocket in PqqC, a cofactorless oxidase catalyzing the final step in PQQ production. (2011) (13)
- Corrigendum: A 21 st century revisionist's view at a turning point in enzymology (2009) (13)
- Epoxide inhibition of alcohol dehydrogenases. Identification of modified cysteines in yeast alcohol dehydrogenase and demonstration of reversible and irreversible inhibition of liver alcohol dehydrogenase by styrene oxide. (1977) (13)
- Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases. (2002) (13)
- Investigation of cu(I)-dependent 2,4,5-Trihydroxyphenylalanine Quinone Biogenesis in Hansenula polymorpha Amine Oxidase* (2006) (13)
- Model studies of topa quinone: synthesis and characterization of topa quinone derivatives. (1995) (13)
- Exponential relationships among multiple hydrogen isotope effects as probes of hydrogen tunneling (1992) (13)
- Stereochemistry of oxidation of benzylamine by the amine oxidase from beef plasma (1979) (12)
- Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone. (2020) (12)
- Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction (2020) (12)
- Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis. (2020) (12)
- Oxygen-18 studies to determine the position of bond cleavage of acetyl phosphate in the presence of divalent metal ions. (1971) (12)
- At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology (2017) (12)
- Temperature-Jump Fluorescence Provides Evidence for Fully Reversible Microsecond Dynamics in a Thermophilic Alcohol Dehydrogenase (2015) (12)
- Insights into the Proposed Copper–Oxygen Intermediates that Regulate the Mechanism of Reactions Catalyzed by Dopamine β‐Monooxygenase, Peptidylglycine α‐Hydroxylating Monooxygenase, and Tyramine β‐Monooxygenase (2011) (12)
- Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida (2017) (12)
- The pyrroloquinoline quinone ( PQQ ) biosynthetic pathway : Demonstration of de novo carbon-carbon cross-linking within the peptide substrate ( PqqA ) in the presence of the Radical SAM enzyme ( PqqE ) and its peptide chaperone ( PqqD ) (2016) (11)
- Redox-active amino acids in biology (1995) (11)
- The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States. (2020) (11)
- Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase. (2008) (10)
- High-performance liquid chromatography separation of the (S,S)- and (R,S)-forms of S-adenosyl-L-methionine. (2015) (10)
- Emerging concepts about the role of protein motion in enzyme catalysis. (2015) (10)
- Identification of Thermal Conduits That Link the Protein-Water Interface to the Active Site Loop and Catalytic Base in Enolase. (2021) (10)
- Crystallographic study of yeast copper amine oxidase. (1997) (9)
- EPR Spectroscopic Identification of the Fe-S Clusters in the SPASM-Domain Containing Radical SAM Enzyme PqqE. (2019) (9)
- Solvent and Temperature Probes of the Long-Range Electron-Transfer Step in Tyramine β-Monooxygenase: Demonstration of a Long-Range Proton-Coupled Electron-Transfer Mechanism (2015) (9)
- Low Barrier Hydrogen Bonds: Getting Close, but Not Sharing... (2015) (9)
- 1H, 13C, and 15N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and the complex of PqqD with PqqA (2016) (9)
- Structural analysis of aliphatic versus aromatic substrate specificity in a copper amine oxidase from Hansenula polymorpha. (2013) (9)
- Structural Properties and Catalytic Implications of the SPASM Domain Iron-Sulfur Clusters in Methylorubrum extorquens PqqE. (2020) (9)
- Synthesis of linoleic acids combinatorially-labeled at the vinylic positions as substrates for lipoxygenases. (2008) (8)
- Role of copper and catalytic mechanism in the copper monooxygenase, dopamine beta-hydroxylase (D beta H). (1988) (8)
- Methods for characterizing TPQ-containing proteins. (2004) (8)
- Solvolysis mechanisms. A kinetic study of the hydrolysis and imidazole-catalyzed hydrolysis of p-methyl-, p-chloro-, and p-nitrobenzoylimidazole in H2O and of p-nitrobenzoylimidazole in deuterium oxide (1968) (7)
- Chapter 6:Beyond Tunnelling Corrections: Full Tunnelling Models for Enzymatic C–H Activation Reactions (2009) (7)
- The widespread occurrence of enzymatic hydrogen tunneling, andits unique properties, lead to a new physical model for the origins of enzyme catalysis (2011) (7)
- Mechanism-based inhibition of dopamine beta-monooxygenase by aldehydes and amides. (1986) (7)
- Methods for Expression, Purification, and Characterization of PqqE, a Radical SAM Enzyme in the PQQ Biosynthetic Pathway. (2018) (7)
- Mechanism of inhibition of dopamine beta-monooxygenase by quinol and phenol derivatives, as determined by solvent and substrate deuterium isotope effects. (1991) (7)
- Mechanisms of biosynthesis of protein-derived redox cofactors. (2001) (7)
- Oxygen-18 Isotope Effects as a Probe of Enzymatic Activation of Molecular Oxygen (2005) (7)
- Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds. (2000) (6)
- Kinetic parameters for dimeric and tetrameric forms of bovine dopamine [3‐monooxygenase and their relationship to non‐Michaelis‐Menten behavior (1999) (6)
- Synthesis of Site-Specifically 13C Labeled Linoleic Acids. (2016) (6)
- Moving Through Barriers in Science and Life. (2019) (6)
- Structural studies of mutant forms of the PQQ‐forming enzyme PqqC in the presence of product and substrate (2010) (6)
- Primary Hydrogen Isotope Effects (1978) (5)
- Functional roles of enzyme dynamics in accelerating active site chemistry: Emerging techniques and changing concepts. (2022) (5)
- Molecular Life Sciences (2018) (5)
- Electron Paramagnetic Resonance Spectroscopic Identification of the Fe–S Clusters in the SPASM-Domain Containing Radical SAM Enzyme PqqE (2020) (5)
- Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine α ketoglutarate dioxygenase (TauD) (2009) (4)
- The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII. (2012) (4)
- New Probes of Oxygen Binding and Activation: Application to Dopamine β-Monooxygenase (1992) (4)
- Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network (2019) (3)
- Surprises among quinoproteins (1991) (3)
- Mechanistic Probes of Copper Amine Oxidases (1989) (3)
- Nuclear Tunneling in the Condensed Phase: Hydrogen Transfer in Enzyme Reactions (2007) (3)
- Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C‐terminal fragment containing both a copper and quino‐cofactor (1995) (3)
- Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1 (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 4, (1146-1151) DOI:10.1073/pnas.0710643105) (2008) (3)
- Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase (2022) (3)
- Identification of quinone cofactors in proteins by resonance Raman spectroscopy (1991) (2)
- Oxygen‐Activating Enzymes, Chemistry of (2008) (2)
- Inactivation of Met471Cys tyramine β-monooxygenase results from site-specific cysteic acid formation. (2012) (2)
- Linking Protein Dynamics to Function (2007) (2)
- Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase. (2023) (1)
- CH···O Interactions Are Not the Cause of Trends in Reactivity and Secondary Kinetic Isotope Effects for Enzymatic SN2 Methyl Transfer Reactions (2016) (1)
- Effects of enzyme glycosylation on the chemical step of catalysis, as probed by hydrogen tunneling and enthalpy of activation (1997) (1)
- NMR structure and binding studies of PqqD, a chaperone required in the biosynthesis of the bacterial dehydrogenase cofactor pyrroloquinoline quinone (2017) (1)
- Use of isotope effects to characterize intermediates in mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine. (1990) (1)
- Thinking Like an Enzyme (2011) (1)
- Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks (2022) (1)
- Mechanisms Whereby Mononuclear Copper Proteins Functionalize Organic Substrates (1997) (1)
- [8] Cloning of mammalian topa quinone-containing enzymes (1995) (1)
- LOOKING IN NEW DIRECTIONS FOR THE ORIGINS OF ENZYMATIC RATE ACCELERATIONS (2014) (1)
- Isotopic Probes of the Soybean Lipoxygenase-1 Mechanism (1996) (1)
- Revealing the Impact of Oxygen on Molecular Biology: The Work of Howard Mason (2016) (1)
- Mechanism of reaction of the copper amine oxidases. (1988) (1)
- SOLVENT ISOTOPE EFFECTS IN THE YEAST ALCOHOL DEHYDROGENASE REACTION (1977) (1)
- Dynamical activation of function in metalloenzymes (2022) (1)
- 1H, 13C, and 15N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and the complex of PqqD with PqqA (2016) (0)
- Two mutations in the active site of alcohol dehydrogenase perturb the catalytic geometry (1996) (0)
- HOW CLOSE ARE WE TO EXPLAINING ENZYME CATALYSIS? (2018) (0)
- Hydrogen atom transfers in B 12 Enzymes by R. Banerjee, D. G. Truhlar, A. Dybala-Defratyka, P. Paneth, in Biological Aspects of Hydrogen Transfer, (2005) (0)
- Dioxygen activation in Hansenula polymorpha amine oxidase (2005) (0)
- Acid base catalysis in designed polypeptides (2006) (0)
- Structural evidence for the semiquinone in a copper amine oxidase from Hansenula polymorpha: implications for the catalytic mechanism (2013) (0)
- Pathway for the stereocontrolled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates. (2006) (0)
- PqqC, Pyrroloquinolinquinone Synthase C (2004) (0)
- CRYSTAL STRUCTURE OF THE VAL203->ALA MUTANT OF LIVER ALCOHOL DEHYDROGENASE COMPLEXED WITH COFACTOR NAD AND INHIBITOR TRIFLUOROETHANOL SOLVED TO 2.5 ANGSTROM RESOLUTION (1998) (0)
- manganese-substituted soybean lipoxygenase-1 (2015) (0)
- Crystal structure of mutant Y305F expressed in E. coli in the copper amine oxidase from hansenula polymorpha (2010) (0)
- Revealing the Role of the Enzyme PqqE in the Biosynthesis of the Important Bacterial Redox Cofactor Pyrroloquinoline Quinone♦ (2016) (0)
- Kinetic parameters for dimeric and tetrameric (3-monooxygenase and their relationship to behavior forms of bovine dopamine non-Michaelis-Menten (1999) (0)
- How Do Enzymes Activate Oxygen Without Inactivating Themselves (2007) (0)
- TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL (1998) (0)
- Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast (2010) (0)
- Crystal structure of copper amine oxidase of yeast (1996) (0)
- FIRST REACTIONS (2021) (0)
- Biogenesis of the peptide-derived redox cofactor PQQ (2020) (0)
- Quinocofactors in Copper Amine Oxidases and Lysyl Oxidase (1996) (0)
- How many ways to craft a cc (2016) (0)
- Structural Analysis of Substrate Specificity in a Copper Amine Oxidase from Hansenula polymorpha (2012) (0)
- How do enzymes speed up chemical reactions? (2022) (0)
- Bovine plasma amine oxidase (PAO) oxidizes substrate by a proton activation mechanism (1986) (0)
- Lipoxygenase-1 (soybean) L546A/L754A mutant (2014) (0)
- Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida (2017) (0)
- Kinetic Isotope Effects (2004) (0)
- Protein function | Kinetic Isotope Effects (2021) (0)
- Tunneling and Dynamics in Enzymatic Hydride Transfer (2006) (0)
- Further Titles of Interest (2006) (0)
- Correction to "Hydrogen-Deuterium Exchange within Adenosine Deaminase, a TIM Barrel Hydrolase, Identifies Networks for Thermal Activation of Catalysis". (2021) (0)
- Modulation of Active Site Picosecond Dynamics in Mutant Forms of a Thermophilic Alcohol Dehydrogenase (HT-ADH) (2014) (0)
- Irwin Rose (1926–2015) (2015) (0)
- Crystal Structural of mutant Y305A in the copper amine oxidase from hansenula polymorpha (2010) (0)
- Sifting through the Haystack to Find the Needle: Spatial Identification of a Structural Conduit for Transfer of Thermal Activation Energy in the Course of C‐H Cleavage in Soybean Lipoxygenase (2016) (0)
- AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD (1998) (0)
- Moving through Barriers: Unlocking the Mysteries of How Enzymes Really Work (2015) (0)
- Structure Function Studies of Dopamine β-Hydroxylase (1990) (0)
- Limited proteolysis of Hansenula polymorpha yeast amine oxidase: isolation of a C-terminal fragment containing both a copper and quino-cofactor (FEBS 15979). (1996) (0)
- Emerging Experimental Probes for the Spatial and Temporal Resolution of Protein Dynamics in Enzyme Catalysis (2021) (0)
- DHFR from Bacillus Stearothermophilus (2005) (0)
- Quinoproteins and Cofactors: Expecting the Unexpected (2007) (0)
- A KINETIC STUDY OF THE HYDROLYSIS AND IMIDAZOLE-CATALYZED HYDROLYSIS OF SUBSTITUTED BENZOYLIMIDAZOLES IN LIGHT AND HEAVY WATER (1966) (0)
- Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope E ff ects Published as part of the Accounts of Chemical Research special issue “ Hydrogen Atom Transfer ” . (2018) (0)
- Eukaryotic Copper Amine Oxidases (2006) (0)
- Editorial overview: Catalysis and regulation. (2015) (0)
- The isolation and characterization of active site peptides in lysyl oxidase (1997) (0)
- Allosteric activation transitions in enzymes and biomolecular motors : insights from atomistic and coarse-grained simulations (2016) (0)
- Cloning of mammalian topa quinone-containing enzymes. (1995) (0)
- Crystal structure of PqqC in complex with PQQ and a putative H2O2 (2004) (0)
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