Karen Wetterhahn | Academic Influence

Karen Wetterhahn's AcademicInfluence.com Rankings

Karen Wetterhahn

Chemistry

#302

World Rank

#590

Historical Rank

#151

USA Rank

chemistry Degrees

Download Badge

Chemistry

Karen Wetterhahn's Degrees

PhD Chemistry Columbia University

Why Is Karen Wetterhahn Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Karen Elizabeth Wetterhahn , also known as Karen Wetterhahn Jennette, was an American professor of chemistry at Dartmouth College, New Hampshire, who specialized in toxic metal exposure. She died of mercury poisoning at the age of 48 due to accidental exposure to the extremely toxic organic mercury compound dimethylmercury . Protective gloves in use at the time of the incident provided insufficient protection, and exposure to only a few drops of the chemical absorbed through the gloves proved to be fatal after less than a year.

(See a Problem?)

Karen Wetterhahn's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. (1996) (288)
Metabolism of the carcinogen chromate by cellular constituents (1983) (234)
Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro. (1995) (216)
Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem. (1989) (211)
Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells 1 (1995) (206)
Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicals. (1994) (159)
The interaction of chromium with nucleic acids. (1983) (156)
Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage. (1991) (155)
In vitro reaction of the carcinogen chromate with cellular thiols and carboxylic acids (1985) (154)
Chromium(VI)-induced DNA lesions and chromium distribution in rat kidney, liver, and lung. (1983) (150)
A prediction of chromium(III) accumulation in humans from chromium dietary supplements (1995) (137)
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription. (1991) (119)
Molecular basis of hexavalent chromium carcinogenicity: effect on gene expression. (1989) (117)
Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism. (1998) (115)
Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis? (1991) (107)
Modification of chromium(VI)-induced DNA damage by glutathione and cytochromes P-450 in chicken embryo hepatocytes. (1985) (105)
Chromium(VI) forms a thiolate complex with glutathione (1991) (102)
Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, and mediates chromium-DNA binding in vitro. (1992) (100)
Binding of chromium to chromatin and DNA from liver and kidney of rats treated with sodium dichromate and chromium(III) chloride in vivo. (1985) (97)
Reaction of chromium (VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage. (1990) (95)
Role of chromium(V), glutathione thiyl radical and hydroxyl radical intermediates in Chromium(VI)‐induced DNA Damage (1989) (93)
Ascorbate is the principal reductant of chromium (VI) in rat liver and kidney ultrafiltrates. (1991) (84)
Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo. (1986) (80)
Chromium(VI) Toxicity: Uptake, Reduction, and DNA Damage (1989) (80)
Interlaboratory validation of a new assay for DNA-protein crosslinks. (1996) (79)
Differential Effects of Chromium(VI) on Constitutive and Inducible Gene Expression in Chick Embryo Liver In Vivo and Correlation With Chromium(VI)‐Induced DNA Damage (1989) (77)
Activation of chromium(VI) by thiols results in chromium(V) formation, chromium binding to DNA and altered DNA conformation. (1991) (74)
Nickel distribution and DNA lesions induced in rat tissues by the carcinogen nickel carbonate. (1982) (70)
Mitochondrial reduction of the carcinogen chromate: formation of chromium(V). (1988) (63)
Reaction of chromium(VI) with thiols: pH dependence of chromium(VI) thio ester formation (1986) (63)
Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA. (1997) (62)
Possible role of glutathione in chromium(VI) metabolism and toxicity in rats. (1991) (59)
Chromium(VI) reduction by ascorbate: role of reactive intermediates in DNA damage in vitro. (1994) (56)
Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. (1998) (55)
Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. (1994) (53)
Chromium cross-links glutathione and cysteine to DNA. (1989) (53)
Nickel-bound chromatin, nucleic acids, and nuclear proteins from kidney and liver of rats treated with nickel carbonate in vivo. (1984) (47)
Chromium(VI) Forms Thiolate Complexes with gamma-Glutamylcysteine, N-Acetylcysteine, Cysteine, and the Methyl Ester of N-Acetylcysteine. (1996) (47)
Chromium toxicity and carcinogenesis. (1990) (46)
In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium(V), chromium-DNA binding and 8-hydroxy-2'-deoxyguanosine in liver and kidney of osteogenic disorder shionogi rats following treatment with chromium(VI). (1999) (45)
Chromium(V) is produced upon reduction of chromate by mitochondrial electron transport chain complexes. (1989) (45)
The carcinogen chromate causes DNA damage and inhibits drug-mediated induction of porphyrin accumulation and glucuronidation in chick embryo hepatocytes. (1983) (41)
Differential binding of chromium(VI) and chromium(III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA. (1993) (38)
Identification of the Oxidized Products Formed upon Reaction of Chromium(V) with Thymidine Nucleotides (1996) (35)
Two pathways for chromium(VI)-induced DNA damage in 14 day chick embryos: Cr-DNA binding in liver and 8-oxo-2'-deoxyguanosine in red blood cells. (1994) (34)
The genotoxic carcinogen chromium(VI) alters the metal-inducible expression but not the basal expression of the metallothionein gene in vivo. (1994) (32)
EPR Evidence for Chromium(V) Binding to Phosphate and Pyrophosphate: Implications for Chromium(V)-DNA Interactions. (1996) (28)
Repair of chromate-induced DNA damage in chick embryo hepatocytes. (1984) (28)
REACTION OF CHROMIUM(V) WITH THE EPR SPIN TRAPS 5,5-DIMETHYLPYRROLINE N-OXIDE AND PHENYL-N-TERT-BUTYLNITRONE RESULTING IN DIRECT OXIDATION (1996) (25)
Intermediates produced in the reaction of chromium(VI) with dehydroascorbate cause single-strand breaks in plasmid DNA. (1997) (25)
Tissue-specific changes in glutathione and cysteine after buthionine sulfoximine treatment of rats and the potential for artifacts in thiol levels resulting from tissue preparation. (1991) (23)
Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes. (1992) (22)
Workshop report from the Division of Research Grants, National Institutes of Health. Metal carcinogenesis--a Chemical Pathology Study Section Workshop. (1992) (21)
Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved? (1992) (18)
In vivo formation of chromium(V) in chick embryo red blood cells. (1990) (18)
In vitro interaction of 63-nickel(II) with chromatin and DNA from rat kidney and liver nuclei. (1985) (16)
In vivo formation of chromium(V) in chick embryo liver and red blood cells. (1992) (16)
Chromium bound to DNA alters cleavage by restriction endonucleases. (1991) (14)
ENVIRONMENTAL METAL CARCINOGENS : GENOTOXICITY AND ALTERED GENE EXPRESSIONBY DIRECT METAL-MEDIATED AND INDIRECT OXIDATIVE PATHWAYS (1996) (11)
Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation. (1997) (11)
Effect of chromium(III) on poly(dG-dC) conformation. (1984) (9)
Molecular basis for the activity of nickel. (1984) (9)
The Mechanisms of Metal Carcinogenicity (1997) (4)
Interaction of metallothionein with the carcinogenic metals Ni(II), Cr(VI) and As(III) (1999) (4)
ANALYSIS OF STEADY-STATE MRNA LEVELS OF CATALASE AND HEME OXYGENASE IN CULTURED RAT FAO CELLS TREATED WITH CHROMIUM(VI), USING SOLUTION HYBRIDIZATION (1994) (3)
Erratum: Chromium(III) picolinate (FASEB Journal (1996) 10 (367-369)) (1996) (2)
The role of ascorbate in metabolism and genotoxicity of chromium(VI). (1993) (2)
Mechanism of chromium(VI) carcinogenesis: Reactive intermediates and interaction with DNA (1989) (1)
Possible mechanisms for arsenic-induced proliferative diseases (1996) (1)
Blakely M. Adair Receives 2001 SBRP Karen Wetterhahn Memorial Award (2002) (0)
Metal Carcinogenesis - A Chemical Pathology Study Section Workshop1 (1992) (0)
Modification ofchromium(VI)-induced DNA damagebyglutathione andcytochromes P-450inchicken embryohepatocytes (1985) (0)
Reduction of Chromium ( V 1 ) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitrot (2001) (0)
Reduction of carcinogenic chromium(VI) by dehydroascorbate and its decomposition products. (1993) (0)

This paper list is powered by the following services:

Other Resources About Karen Wetterhahn

en.wikipedia.org

What Schools Are Affiliated With Karen Wetterhahn?

Karen Wetterhahn is affiliated with the following schools:

Image Attributions

Image Source for Karen Wetterhahn