Mario Capecchi
#2,141
Most Influential Person
Molecular geneticist and Nobel laureate
Why Is Mario Capecchi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mario Ramberg Capecchi is an Italian-born molecular geneticist and a co-awardee of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine.
Mario Capecchi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells (1987) (2246)
- Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes (1988) (1624)
- Altering the genome by homologous recombination. (1989) (1471)
- Bmi1 is expressed in vivo in intestinal stem cells (2008) (1158)
- High efficiency transformation by direct microinjection of DNA into cultured mammalian cells (1980) (915)
- Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development (1990) (911)
- Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 (1991) (842)
- The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011) (718)
- Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche (2009) (710)
- Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century (2005) (668)
- Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11 (1995) (592)
- The new mouse genetics: altering the genome by gene targeting. (1989) (589)
- High frequency targeting of genes to specific sites in the mammalian genome (1986) (573)
- The Knockout Mouse Project (2004) (572)
- Retinopathy induced in mice by targeted disruption of the rhodopsin gene (1997) (525)
- Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6 (1992) (519)
- Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton (2003) (461)
- Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. (1993) (458)
- Gene Regulatory Networks in the Evolution and Development of the Heart (2006) (455)
- Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. (1996) (446)
- The role of Hoxa-3 in mouse thymus and thyroid development. (1995) (440)
- Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules (1982) (412)
- Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus (1992) (393)
- Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice (2010) (377)
- An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. (2002) (370)
- Hoxb8 Is Required for Normal Grooming Behavior in Mice (2002) (356)
- Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. (1993) (349)
- Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. (2000) (326)
- Fgf8 is required for outgrowth and patterning of the limbs (2000) (325)
- Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. (2003) (303)
- Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. (1998) (299)
- Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. (1996) (296)
- A mouse model for the delta F508 allele of cystic fibrosis. (1995) (293)
- Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. (2004) (292)
- The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. (1997) (281)
- Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. (1994) (274)
- A conditional mouse model of synovial sarcoma: insights into a myogenic origin. (2007) (265)
- Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. (1995) (262)
- Hox11 paralogous genes are essential for metanephric kidney induction. (2002) (259)
- Targeting genes for self-excision in the germ line. (1999) (259)
- Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions (1994) (256)
- Hoxc13 mutant mice lack external hair. (1998) (247)
- Swaying is a mutant allele of the proto-oncogene Wnt-1 (1991) (245)
- Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. (2004) (243)
- Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. (1993) (241)
- A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. (1996) (238)
- Hox patterning of the vertebrate rib cage (2007) (227)
- Targeted gene replacement. (1994) (225)
- N-formylmethionyl-sRNA as the initiator of protein synthesis. (1966) (218)
- Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene (1986) (212)
- Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. (2004) (210)
- Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension (2014) (206)
- Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. (1999) (205)
- The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. (2002) (203)
- The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. (2004) (197)
- Xanthine oxidoreductase is central to the evolution and function of the innate immune system. (2003) (193)
- Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA (1983) (190)
- Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. (1999) (190)
- Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor (1965) (189)
- Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo (2006) (182)
- Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. (2000) (180)
- Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function* (2004) (177)
- Polypeptide chain termination in vitro: isolation of a release factor. (1967) (173)
- Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. (1997) (170)
- Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping (2006) (169)
- Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. (2011) (167)
- Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. (2001) (160)
- High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors (1992) (157)
- Evolution of the mammary gland from the innate immune system? (2006) (156)
- Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. (2000) (156)
- Hoxb13 is required for normal differentiation and secretory function of the ventral prostate (2003) (151)
- Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. (1997) (146)
- Biomarker system for studying muscle, stem cells, and cancer in vivo (2009) (144)
- Maintenance of functional equivalence during paralogous Hox gene evolution (2000) (144)
- Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. (1996) (143)
- Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. (2003) (142)
- Toward simpler and faster genome-wide mutagenesis in mice (2007) (142)
- Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. (1997) (142)
- Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. (1996) (140)
- Altered enzymes in drug-resistant variants of mammalian tissue culture cells. (1973) (138)
- Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. (2008) (136)
- Hox genes and mammalian development. (1997) (133)
- Normal limb development in conditional mutants of Fgf4. (2000) (132)
- Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. (1997) (130)
- Hox genes define distinct progenitor sub-domains within the second heart field. (2011) (129)
- Bmi1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor (2013) (126)
- ELOVL3 Is an Important Component for Early Onset of Lipid Recruitment in Brown Adipose Tissue* (2006) (126)
- Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod (2003) (125)
- Generating mice with targeted mutations (2001) (124)
- Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. (2012) (122)
- Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column (1994) (121)
- Bmi 1 is expressed in vivo in intestinal stem cells (2010) (121)
- Cell-free protein synthesis programmed with R17 RNA: identification of two phage proteins. (1966) (119)
- A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes (2010) (118)
- Targeted disruption of Hoxd-10 affects mouse hindlimb development. (1997) (115)
- Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. (1990) (113)
- Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis* (2012) (112)
- Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei (1985) (111)
- Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo (2008) (109)
- A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond (2008) (109)
- Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. (2007) (107)
- Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons (2007) (104)
- Characterization of three proteins involved in polypeptide chain termination. (1969) (102)
- T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis (2011) (101)
- Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse (2014) (100)
- Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis (2009) (98)
- Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. (2012) (98)
- Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. (2012) (97)
- ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice (2011) (94)
- Location of crossovers during gene targeting with insertion and replacement vectors (1993) (93)
- Selective degradation of abnormal proteins in mammalian tissue culture cells. (1974) (92)
- Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. (2007) (91)
- Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons (2003) (91)
- Reversal of Hox1 gene subfunctionalization in the mouse. (2006) (91)
- Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice* (2004) (91)
- Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. (1994) (89)
- Synovial Sarcoma: From Genetics to Genetic-based Animal Modeling (2008) (89)
- Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. (2007) (85)
- Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd 1-Deficient Hepatocytes (2009) (84)
- Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae (1998) (84)
- Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. (1999) (84)
- Initiation of E. coli proteins. (1966) (82)
- Cardiovascular defects in a mouse model of HOXA1 syndrome. (2012) (82)
- Two distinct ontogenies confer heterogeneity to mouse brain microglia (2018) (80)
- Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes (1982) (79)
- Lineage of origin in rhabdomyosarcoma informs pharmacological response (2014) (79)
- A Targeted Neuroglial Reporter Line Generated by Homologous Recombination in Human Embryonic Stem Cells (2009) (77)
- The mouse Hoxc11 gene: genomic structure and expression pattern (1998) (72)
- Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure (2002) (72)
- Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways. (2000) (72)
- Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. (1998) (71)
- Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase (1987) (70)
- The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. (2018) (67)
- piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice (2017) (67)
- Male fertility is dependent on dipeptidase activity of testis ACE (2005) (67)
- Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. (2012) (65)
- Targeting the Wnt pathway in synovial sarcoma models. (2013) (63)
- Immunological characterization of hypoxanthine‐guanine phosphoribosyl transferase mutants of mouse L cells: Evidence for mutations at different loci in the HGPRT gene (1975) (62)
- Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. (1985) (62)
- Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. (2004) (61)
- Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. (1975) (60)
- An Fgf 8 mouse mutant phenocopies human 22 q 11 deletion syndrome (2002) (59)
- Hoxb1 neural crest preferentially form glia of the PNS (2003) (59)
- Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. (2014) (59)
- A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. (2013) (58)
- ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. (2015) (58)
- Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse (2015) (57)
- Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei (2013) (54)
- Analysis of homologous recombination in cultured mammalian cells. (1984) (53)
- Contribution of Hox genes to the diversity of the hindbrain sensory system (2004) (53)
- An evolving NGF–Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates (2010) (52)
- Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays (1986) (52)
- Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. (2011) (52)
- New genetic tactics to model alveolar rhabdomyosarcoma in the mouse. (2005) (51)
- Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. (2010) (51)
- The isolation of a suppressible nonsense mutant in mammalian cells (1977) (50)
- Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro (1975) (49)
- Sequence-Independent Assembly of Spermatid mRNAs into Messenger Ribonucleoprotein Particles (1999) (48)
- The Protocadherin Gene Celsr3 Is Required for Interneuron Migration in the Mouse Forebrain (2009) (45)
- Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. (2015) (45)
- Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. (2002) (44)
- Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II (2003) (44)
- Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System (2002) (43)
- The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse (2014) (43)
- TAXI/UAS: A molecular switch to control expression of genes in vivo. (1996) (42)
- Hoxb2 and hoxb4 act together to specify ventral body wall formation. (2001) (41)
- Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse (2014) (41)
- Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration (2010) (40)
- How close are we to implementing gene targeting in animals other than the mouse? (2000) (40)
- Corticostriatal circuit defects in Hoxb8 mutant mice (2017) (40)
- Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. (2013) (40)
- Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. (2014) (39)
- A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. (2009) (39)
- Release Factors mediating Termination of Complete Proteins (1970) (39)
- Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei (1985) (38)
- Practical Vessel Imaging by Computed Tomography in Live Transgenic Mouse Models for Human Tumors (2005) (38)
- Polarity in vitro. (1967) (38)
- The c.480C>G polymorphism of hOCT1 influences imatinib clearance in patients affected by chronic myeloid leukemia (2014) (38)
- Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. (1986) (37)
- Cardiac Bmi1+ cells contribute to myocardial renewal in the murine adult heart (2015) (36)
- Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice (2015) (35)
- ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells (2017) (35)
- SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas (2013) (35)
- Bortezomib reverses a post‐translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma (2009) (34)
- Function of Homeobox Genes in SkeletAl Development (1996) (31)
- The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis (2016) (29)
- A rapid assay for polypeptide chain termination. (1967) (29)
- β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition (2015) (29)
- Polypetide chain termination. Purification of the release factors, R1 and R2, from Escherichia coli. (1971) (29)
- Deep-brain imaging via epi-fluorescence Computational Cannula Microscopy (2017) (28)
- An examination of the Chiropteran HoxD locus from an evolutionary perspective (2008) (28)
- Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. (1984) (27)
- Nicotinic Receptor Alpha7 Expression Identifies a Novel Hematopoietic Progenitor Lineage (2013) (27)
- Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation (2015) (27)
- Midline signaling regulates kidney positioning but not nephrogenesis through Shh. (2010) (26)
- Hair defects in Hoxc13 mutant mice. (1999) (26)
- Modeling synovial sarcoma metastasis in the mouse: PI3′-lipid signaling and inflammation (2016) (26)
- Measurement of suppressor transfer RNA activity. (1983) (25)
- The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. (2018) (25)
- Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development. (2004) (25)
- Recombinant DNA Technique and Sickle Cell Anemia Research (1997) (25)
- Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling (2015) (24)
- Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms. (2008) (24)
- In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette (2008) (24)
- Protein synthesis directed by DNA phage messengers. (1966) (23)
- Fundamental Cellular Processes Do Not Require Vertebrate-specific Sequences within the TATA-binding Protein* (2003) (23)
- Effect of cell cycle position on transformation by microinjection (1985) (23)
- Targeting of genes to specific sites in the mammalian genome. (1986) (22)
- Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning (2018) (21)
- Prenatal Ablation of Nicotinic Receptor alpha7 Cell Lineages Produces Lumbosacral Spina Bifida the Severity of Which is Modified by Choline and Nicotine Exposure (2012) (20)
- Choose your target (2000) (20)
- Toward an understanding of the short bone phenotype associated with multiple osteochondromas (2013) (17)
- A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion. (2019) (17)
- Cannula-based computational fluorescence microscopy (2015) (16)
- Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells (2014) (16)
- How efficient can you get? (1990) (16)
- YACs to the rescue (1993) (14)
- A functional Jak2 tyrosine kinase domain is essential for mouse development. (2006) (14)
- Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements (2016) (13)
- Erratum: The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma (Cancer Cell (2018) 33(3) (527–541.e8) (S1535610818300187) (10.1016/j.ccell.2018.01.018)) (2018) (13)
- Fractionation of a suppressor sRNA. (1966) (12)
- Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life (2020) (12)
- Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration (2010) (11)
- Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus. (2008) (11)
- HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression (2019) (11)
- Fine-Tuning of iPSC Derivation by an Inducible Reprogramming System at the Protein Level (2014) (10)
- Tapping the cellular telephone (1990) (9)
- Paracrine osteoprotegerin and &bgr;-catenin stabilization support synovial sarcomagenesis in periosteal cells (2017) (9)
- The clear cell sarcoma functional genomic landscape. (2021) (9)
- Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. (2011) (8)
- The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis (2017) (8)
- In Vivo and In Vitro Tissue‐Specific Expression of Green Fluorescent Protein Using the Cre‐Lox System in Mouse Embryonic Stem Cells (2005) (8)
- Response: Contributions of the Myf5-independent lineage to myogenesis. (2014) (7)
- Corticostriatal circuit defects in Hoxb8 mutant mice. (2017) (7)
- Efficient generation of selection‐gene‐free rat knockout models by homologous recombination in ES cells (2016) (7)
- A Mouse Model for the AF 508 Allele of Cystic Fibrosis (2013) (7)
- Gene targeting. How efficient can you get? (1990) (7)
- HOXC 8 initiates an ectopic mammary program by regulating Fgf 10 and Tbx 3 expression , and Wnt / β-catenin signaling (2015) (6)
- Lessons from angiotensin-converting enzyme-deficient mice. (1996) (5)
- A brief review of genome editing technology for generating animal models (2020) (5)
- Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences. (1999) (5)
- Site-Specific Recombination with Inverted Target Sites: A Cautionary Tale of Dicentric and Acentric Chromosomes (2020) (5)
- A Nobel lesson: the grant behind the prize. Response. (2008) (4)
- The origin and evolution of gene targeting. (2021) (4)
- Derivation of Transgene‐Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells (2016) (4)
- Enhanced chromosome extraction from cells using a pinched flow microfluidic device (2020) (4)
- The Making of a Scientist II (Nobel Lecture) (2008) (4)
- Molecular genetics of early Drosophila and mouse development (1989) (3)
- Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions (1994) (3)
- Paralogous mouse Hox genes, Ho together to control development response to pregnancy (2016) (3)
- ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control (2021) (3)
- Size and shape based chromosome separation in the inertial focusing device. (2020) (3)
- The role of Hox genes in hindbrain development (2009) (3)
- Erratum: Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions (Nature (1994) 370 (304-307)) (1994) (2)
- An Interview With... (2005) (2)
- cooperativity of Ink 4 a / ARF and Trp 53 loss of function mice : Pax 3 : FkhrAlveolar rhabdomyosarcomas in conditional data (2004) (2)
- Correction: Two distinct ontogenies confer heterogeneity to mouse brain microglia (doi: 10.1242/dev.152306) (2019) (2)
- Gene Targeting : Altering the Genome in Mice (2002) (2)
- Chapter 2 – Gene Targeting (2012) (2)
- The role of FGF4 and FGF8 in posterior development of the mouse embryo (2008) (2)
- Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins (2017) (2)
- In vivo three-photon imaging of deep cerebellum (2018) (1)
- THE PILOTING ADVISORY SYSTEM (1990) (1)
- Bmi1 in Self-Renewal and Homeostasis of Pancreas (2011) (1)
- implications for alveolar rhabdomyosarcoma cell of origin function: Pax7 and (2006) (1)
- Hoxa1-lineage analysis suggests novel domains of Hoxa1 function (2006) (1)
- Cytoprotective Nrf 2 pathway is induced in chronically thioredoxin reductase 1-deficient hepatocytes (2009) (1)
- The first transgenic mice: an interview with Mario Capecchi. Interview by Kristin Kain. (2008) (1)
- 10 Bacteriophage RNA as Template for In Vitro Protein Synthesis (1975) (1)
- Mouse genetics. YACs to the rescue. (1993) (1)
- Gene targeting: tapping the cellular telephone. (1990) (1)
- Animal Model Mice with Cardiac-Restricted Angiotensin-Converting Enzyme (ACE) Have Atrial Enlargement, Cardiac Arrhythmia, and Sudden Death (2004) (1)
- Gene targeting: an historical perspective (1998) (1)
- An interview with... Mario Capecchi. Interview by Magdalena Skipper. (2005) (1)
- Dominant negative effect on male fertility and sperm maturation by haploinsufficiency of ELOVL2 in mouse (2010) (1)
- Mice bearing a targeted inactivation of nBmp2 show decreased muscle strength (2009) (1)
- Enhanced chromosome extraction from cells using a pinched flow microfluidic device (2020) (0)
- Virtual H isto logy o f Transgenic M ouse (0)
- A structural analysis of the myotis lucifugus genome (2006) (0)
- Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei (2013) (0)
- - CeAb1: Abl-related PTK (C. elegans) (1995) (0)
- ORIGINAL ARTICLE: Syngeneic Immune‐Dependent Abortions in Mice Suggest Paternal Alloantigen‐Independent Mechanisms (2008) (0)
- Mice bearing a targeted mutation of nBmp2 display decreased memory capabilities (2010) (0)
- Dean flow fractionation of chromosomes (2016) (0)
- Computation-Enabled Lensless Imaging & Deep-Brain Microscopy (2019) (0)
- WITHDRAWN: Analysing the role of Hoxa1 in mammalian hindbrain, inner ear and cardiovascular development (2007) (0)
- NOTES Homologous Recombination between Coinjected DNA Sequences PeaksinEarly toMid-SPhase (1987) (0)
- Abstract 4195: Tetracycline inducible expression of synovial sarcoma associated SYT-SSX2 fusion gene in a new mouse model (2010) (0)
- In vitro evaluation of the influence of pH in the bactericidal activity of a sodium hypochlorite 0.5% versus Enterococcus faecalis (2006) (0)
- The vibrational spectra of phosphorous oxynitride at high pressures (2001) (0)
- The Fifth Annual Meeting of the Society for Molecular Imaging (2006) (0)
- Generation of mouse embryonic stem cells for time-and tissue-specific cre transgene expression in living mice (2004) (0)
- SYMPOSIUM: MOLECULAR GENETICS IN SARCOMA (2008) (0)
- A cannula-based computational fluorescence microscope (2015) (0)
- High-Fidelity GeneTargeting inEmbryonic StemCells by UsingSequence Replacement Vectors (1992) (0)
- Computational Cannula Microscopy: Utilizing a Simple Glass Needle for Imaging (2018) (0)
- A 11 Patent Number : 5 , 789 , 215 45 Date of Patent : Aug . 4 , 1998 (2017) (0)
- Masking techniques: masking selected sequence variation by incorporating mismatches into melting analysis probes (0)
- A PRACTICAL APPROACH TO THERAPEUTIC DRUG MONITORING OF IMATINIB IN PATIENTS AFFECTED BY CHRONIC MYELOID ELEUKEMIA. THE TIKLET PROTOCOL. (2012) (0)
- Gene modification in mice Introduction (2007) (0)
- Defining the Hoxb8 cell lineage during murine definitive hematopoiesis (2022) (0)
- Mario Capecchi: The Birth of Gene Targeting (2011) (0)
- Deep tissue fluorescent imaging via computational cannula microscopy (2017) (0)
- Selenoprotein P (Sepp1) Synthesis by the Liver Protects against Selenium Deficiency (2012) (0)
- ETV4/5 drive synovial sarcoma through control of the cell cycle and the DUX4 embryonic pathway. (2021) (0)
- A cannula-based computational fluorescence microscope for neuronal imaging (2015) (0)
- 1993 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1325 (0)
- Supplementary material from "Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements" (2016) (0)
- Conferences and courses (1995) (0)
- Neuroprotection and Inhibition of Blood-Retinal Barrier Breakdown In a Transgenic Model of Conditional Müller Cell Ablation (2012) (0)
- Introduction: The molecular genetic analysis of mouse development (1995) (0)
- Table of Contents (1984) (0)
- An inertial microfluidic device for rapid purification of native chromosomes (2014) (0)
- Mice with targeted inactivation of nBmp2 exhibit increased daytime activity (2009) (0)
- Site-specific recombination between inverted target sites generates dicentric/acentric chromosomes (2020) (0)
- DEV110833 1..12 (2014) (0)
- INITIATION OF E. COLI PROTENINS* BY MARIO R. CAPECCHI (0)
- ISDB News (2005) (0)
- Comparison of genotype/phenotype associations between mice and men (1998) (0)
- Genomics in the Neonatal Nursery: Focus on ROP (2015) (0)
- CreERT2 knock-in mice (2021) (0)
- Modèle animal d'un sarcome synovial (2008) (0)
- Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity- A Multicenter Study. (2022) (0)
- 5. Modeling Synovial Sarcoma from initiation through metastasis (2018) (0)
- Classification : Developmental Biology Axial Structures Regulate Mediolateral Patterning of the Metanephric Kidney through Shh (2009) (0)
- Computational Cannula Microscopy: Fluorescent imaging through ultra-thin glass needle (2017) (0)
- Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming (2016) (0)
- Abstract C12: Beta-catenin enhances synovial sarcomagenesis and provides a therapeutic target. (2013) (0)
- Editorial board members (2007) (0)
- Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells. (2016) (0)
- Autism Treatment Account Advisory Committee (2013) (0)
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