Mitsuo Oshimura

Q: What Schools Are Affiliated With Mitsuo Oshimura

Mitsuo Oshimura is affiliated with the following schools: Tohoku University, Tottori University, Osaka University, Kyoto University

Mitsuo Oshimura's AcademicInfluence.com Rankings

Mitsuo Oshimura

Biology

#9303

World Rank

#12491

Historical Rank

Genetics

#948

World Rank

#1044

Historical Rank

biology Degrees

Download Badge

Biology

Mitsuo Oshimura's Degrees

PhD Biology Kyoto University

Why Is Mitsuo Oshimura Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Mitsuo Oshimura's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PI3K-Akt pathway: Its functions and alterations in human cancer (2004) (1168)
Generation of Pluripotent Stem Cells from Neonatal Mouse Testis (2004) (810)
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts (2016) (533)
Dicer is essential for formation of the heterochromatin structure in vertebrate cells (2004) (518)
Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting. (1999) (388)
Positional cloning of the gene for Nijmegen breakage syndrome (1998) (340)
Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy (2012) (339)
Dynamics of epigenetic regulation at the single-cell level (2016) (335)
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia (2007) (334)
Telomere lengths are characteristic in each human individual (2002) (297)
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. (1995) (283)
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation (2004) (280)
FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA (2005) (276)
CTCF-dependent chromatin insulator is linked to epigenetic remodeling. (2006) (267)
MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. (2011) (264)
Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice (1997) (255)
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress (2007) (249)
Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy (2009) (248)
LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. (1999) (233)
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. (2003) (229)
Genetic and epigenetic properties of mouse male germline stem cells during long-term culture (2005) (221)
Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18 (1991) (206)
Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. (2000) (201)
SIRT2 down‐regulation in HeLa can induce p53 accumulation via p38 MAPK activation‐dependent p300 decrease, eventually leading to apoptosis (2011) (191)
Chromosomes and causation of human cancer and leukemia. XXVI. Banding studies in acute lymphoblastic leukemia (ALL) (1977) (183)
Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome. (2000) (178)
Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome (2000) (178)
DNA-PKcs is critical for telomere capping (2001) (177)
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. (1997) (170)
Monoallelic BUB1B mutations and defective mitotic‐spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome (2006) (164)
Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. (2006) (157)
A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome (2001) (157)
Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. (1992) (152)
Construction of Mouse A9 Clones Containing a Single Human Chromosome Tagged with Neomycin‐resistance Gene via Microcell Fusion (1989) (150)
Stem Cell–Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy (2011) (146)
Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray. (2002) (146)
Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome. (2004) (145)
Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (1992) (143)
Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts (2000) (142)
Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa (1989) (142)
Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. (2008) (142)
The Molecular Biology of Mammalian SIRT Proteins: SIRT2 Functions on Cell Cycle Regulation (2007) (141)
ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith–Wiedemann syndrome (2005) (136)
The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. (1999) (135)
Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA (2000) (132)
Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome. (2004) (132)
Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. (2016) (128)
Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. (2009) (128)
Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 (1995) (124)
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome. (2001) (123)
Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling. (2003) (118)
Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. (1992) (115)
Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML) (1976) (115)
Deletion mapping of chromosome 3p in human uterine cervical cancer. (1993) (107)
Refined human artificial chromosome vectors for gene therapy and animal transgenesis (2010) (106)
Telomere shortening with aging in human liver. (2000) (106)
Proteomic identification of differentially‐expressed genes in human gastric carcinomas (2005) (105)
Human artificial chromosomes for gene delivery and the development of animal models. (2011) (105)
Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers (2006) (103)
A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene. (2009) (103)
Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. (1990) (102)
Epigenetic heterogeneity at imprinted loci in normal populations. (2001) (101)
Mouse U2af1-rs1 is a neomorphic imprinted gene (1997) (100)
Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes (1985) (99)
Construction of a novel human artificial chromosome vector for gene delivery. (2004) (98)
A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. (2001) (98)
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. (2003) (94)
Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma (2001) (92)
Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8. (1994) (92)
Evidence for uniparental, paternal expression of the human GABAA receptor subunit genes, using microcell-mediated chromosome transfer. (1997) (91)
Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. (1990) (91)
Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. (2002) (90)
A 3‐Mb physical map of the chromosome region 8p21.3‐p22, including a 600‐kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non‐small cell lung cancer (1994) (90)
Evidence for multiple pathways to cellular senescence. (1994) (84)
Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence (1998) (82)
8-21 TRANSLOCATION AND MISSING SEX CHROMOSOMES IN ACUTE LEUKÆMIA (1974) (82)
Transfer of a normal human chromosome 11 suppresses tumorigenicity of some but not all tumor cell lines (1990) (81)
Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. (1989) (81)
Epigenetic silencing of PEG3 gene expression in human glioma cell lines * (2001) (80)
Erratum: LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids (Human Molecular Genetics (1999) 8 (1209-1217)) (1999) (80)
A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids. (2003) (80)
Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes. (2001) (78)
Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes. (2003) (76)
A Method for Producing Transgenic Cells Using a Multi-Integrase System on a Human Artificial Chromosome Vector (2011) (75)
Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. (1999) (74)
Epigenetic Regulation of ARHI in Breast and Ovarian Cancer Cells (2003) (74)
Identification of PITX1 as a TERT Suppressor Gene Located on Human Chromosome 5 (2011) (73)
Evidence for a putative telomerase repressor gene in the 3p14.2–p21.1 region (1998) (71)
A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. (2000) (70)
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells (2011) (69)
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. (2003) (68)
Correlation of telomere lengths in normal and cancers tissue in the large bowel. (2000) (68)
Chromosomes and causation of human cancer and leukemia. XXIII. Near‐haploidy in acute leukemia (1977) (68)
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors (2011) (68)
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. (2013) (67)
Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10 (1995) (67)
A summary of cytogenetic studies on 534 cases of chronic myelocytic leukemia in Japan. (1983) (67)
A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges (2015) (66)
Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression (2010) (65)
Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24. (1997) (65)
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts (2005) (63)
Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. (2002) (62)
Regulation of functional KCNQ1OT1 lncRNA by β-catenin (2016) (62)
XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation (1998) (61)
Fluorescence and Giemsa banding studies of the allocyclic X chromosome in embryonic and adult mouse cells. (1973) (61)
miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells (2015) (61)
Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. (2011) (61)
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest (2009) (60)
Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome (2013) (60)
Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older (2007) (59)
Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors (2003) (59)
Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DT40 cells. (1998) (59)
Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell‐mediated chromosome transfer (1993) (58)
Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development* (2012) (58)
Chromosomes and causation of human cancer and leukemia. XX. Banding patterns of primary tumors. (1977) (58)
Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status. (2004) (57)
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer (2004) (54)
A novel and stable mouse artificial chromosome vector. (2014) (54)
Identification of the human homolog of the imprinted mouse Air non-coding RNA. (2008) (54)
A Dyad Oct-binding Sequence Functions as a Maintenance Sequence for the Unmethylated State within theH19/Igf2-imprinted Control Region* (2002) (53)
5-Fluorouracil (5-FU) induced apoptosis in gastric cancer cell lines: role of the p53 gene (2004) (53)
Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology (2017) (53)
SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors (2014) (53)
Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. (2006) (52)
Telomere shortening with aging in the human pancreas (2006) (52)
Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture (2014) (51)
Soluble c-kit receptor mobilizes hematopoietic stem cells to peripheral blood in mice. (2004) (51)
Suggestive evidence for chromosomal localization of non-coding RNA from imprinted LIT1 (2007) (51)
Variant Ph1 translocations in CML and their incidence, including two cases with sequential lymphoid and myeloid crises. (1982) (50)
Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa (1995) (50)
Mapping of metastasis suppressor gene(s) for rat prostate cancer on the short arm of human chromosome 8 by irradiated microcell‐mediated chromosome transfer (1996) (50)
CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region. (2008) (50)
Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. (2012) (49)
Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes (2011) (49)
Epigenetic mechanisms in human disease. (2002) (48)
Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma (1997) (48)
Telomerase activity in esophageal carcinoma (1997) (48)
Tumor suppressive role of a 2.4 Mb 9q33–q34 critical region and DEC1 in esophageal squamous cell carcinoma (2005) (47)
Suggestive evidence for functionally distinct, tumor-suppressor genes on chromosomes 1 and 11 for a human fibrosarcoma cell line, HT1080. (1990) (47)
Loss of imprinting of PEG1/MEST in lung cancer cell lines. (2004) (47)
Functional evidence for a telomerase repressor gene on human chromosome 10p15.1 (2001) (47)
Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability. (2000) (47)
Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence. (2003) (46)
Trisomy of the long arm of chromosome No. 1 in human leukemia. (1976) (45)
Paternal expression of WT1 in human fibroblasts and lymphocytes. (1997) (45)
Cytogenetic and immunoglobulin markers of human leukemic B-cell lines. (1977) (45)
A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells (2005) (45)
Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb (2003) (45)
Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. (2002) (43)
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome. (2003) (43)
The chromosomes and causation of human cancer and leukemia. XIX. Common markers in various tumors (1976) (43)
Chromosomes and causation of human cancer and leukemia. XXV. Significance of the Ph1 (including unusual translocations) in various acute leukemias (1977) (42)
Transfer of human artificial chromosome vectors into stem cells. (2008) (42)
Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues (2004) (42)
Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain (2004) (41)
Significant Correlation of Telomerase Activity in Thyroid Papillary Carcinomas with Cell Differentiation, Proliferation and Extrathyroidal Extension (1997) (41)
Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient–derived cardiomyocytes (2014) (40)
Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. (2002) (40)
14-3-3 Is Involved in p75 Neurotrophin Receptor-mediated Signal Transduction* (2001) (40)
Chromosomal banding patterns in primary and transplanted venereal tumors of the dog. (1973) (40)
Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma (2004) (40)
Stability of transferred human chromosome fragments in cultured cells and in mice (2004) (40)
Loss of Imprinting of Long QT Intronic Transcript 1 in Colorectal Cancer (2001) (39)
A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21 (2020) (39)
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome (2008) (38)
Production of knockout mice by gene targeting in multipotent germline stem cells. (2007) (38)
Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6 (2001) (38)
Establishment and characterization of leukemic T-cell lines, B-cell lines, and null-cell line: a progress report on surface antigen study of fresh lymphatic leukemias in man. (1977) (38)
Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. (1994) (37)
Functional evidence for involvement of multiple putative tumor suppressor genes on the short arm of chromosome 3 in human oral squamous cell carcinogenesis. (1998) (36)
Metastasis suppressor genes for prostate cancer (1996) (36)
Gene rearrangement and truncated mRNA in cell lines with 11q23 translocation. (1993) (36)
Calcr, a brain-specific imprinted mouse calcitonin receptor gene in the imprinted cluster of the proximal region of chromosome 6 (2003) (36)
Isochromosome 17 in prostatic cancer. (1975) (35)
A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome (2014) (35)
Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. (1995) (35)
The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11. (1996) (34)
Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas (1998) (34)
Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (1995) (34)
Chromosomes and causation of human cancer and leukemia. XXI. Cytogenetically unusual cases of leukemia (1976) (33)
Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model (2016) (33)
Detection of telomerase activity in prostate cancer by needle biopsy. (1997) (33)
In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion (1994) (33)
Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer (1999) (33)
Genetic Complementation of the Immortal Phenotype in Group D Cell Lines by Introduction of Chromosome 7 (1995) (32)
Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer (2010) (32)
Mapping a novel cellular‐senescence gene to human chromosome 2q37 by irradiation microcell‐mediated chromosome transfer (1998) (32)
The expansion of the CAG repeat in exon 1 of the human androgen receptor gene is associated with uterine endometrial carcinoma (2000) (32)
Phage ϕC31 integrase‐mediated genomic integration of the common cytokine receptor gamma chain in human T‐cell lines (2006) (31)
Highly stable maintenance of a mouse artificial chromosome in human cells and mice. (2013) (31)
Metastasis suppressor gene(s) for rat prostate cancer on the long arm of human chromosome 7 (1999) (31)
Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN‐1 (2007) (31)
Ku70/80 Modulates ATM and ATR Signaling Pathways in Response to DNA Double Strand Breaks* (2007) (31)
Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins (2016) (30)
Isolation and mapping of 68 RFLP markers on human chromosome 6. (1992) (30)
Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma (2009) (30)
Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice (2001) (30)
Suppression of tumorigenicity and invasiveness of colon carcinoma cells by introduction of normal chromosome 8p12-pter. (1996) (30)
Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver[S] (2013) (29)
An induced pluripotent stem cell-mediated and integration-free factor VIII expression system. (2013) (29)
Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. (2004) (29)
Identification of a Mutated DNA Ligase IV Gene in the X-ray-hypersensitive Mutant SX10 of Mouse FM3A Cells* (2001) (28)
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies (2014) (28)
Human artificial chromosome vectors meet stem cells: new prospects for gene delivery. (2006) (28)
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8. (1998) (28)
Hereditary renal cell carcinoma in the rat associated with nonrandom loss of chromosomes 5 and 6. (1991) (28)
Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia, including one case with a complex translocation. (1985) (28)
A repressor function for telomerase activity in telomerase‐negative immortal cells (1998) (27)
Ectopic Expression of wnt-5a in Human Renal Cell Carcinoma Cells Suppresses in vitro Growth and Telomerase Activity (1998) (27)
N-Band polymorphism of human acrocentric chromosomes and its relevance to satellite association (2004) (27)
Human chromosome 9 can complement UV sensitivity of xeroderma pigmentosum group A cells. (1990) (27)
Factor(s) responsible for the increase in alkaline phosphatase activity of postmitotic granulocytes from normal individuals and patients with chronic myeloid leukemia. (1982) (27)
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells (2010) (26)
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site (2021) (26)
Ultrasound and Embryonic Chromosomes (1973) (26)
Identification of the Chromatin Regions Coated by Non-coding Xist RNA (2009) (26)
Construction of a novel expression system on a human artificial chromosome. (2005) (26)
Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy (2017) (25)
A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT (2009) (25)
Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines. (2006) (25)
A novel in vitro system for analyzing parental allele-specific histone acetylation in genomic imprinting (2001) (25)
Isolation and mapping of 88 new RFLP markers on human chromosome 8. (1992) (25)
Possible mechanisms for the genesis of common chromosome abnormalities, including isochromosomes and the philadelphia chromosome. (1977) (25)
Human chromosome 5 carries a putative telomerase repressor gene (2003) (25)
Topoisomerase II cleavage activity within the human D11Z1 and DXZ1 alpha-satellite arrays (2005) (24)
Telomerase Activity Significantly Correlates with Chromosome Alterations, Cell Differentiation, and Proliferation in Lung Adenocarcinomas (2000) (24)
Induction of genomic instability and activation of autophagy in artificial human aneuploid cells. (2016) (24)
DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex (2008) (24)
Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver (2015) (24)
Nonrandom chromosome alterations that correlate with progression to immortality in rat tracheal epithelial cells transformed with N-methyl-N'-nitro-N-nitrosoguanidine. (1990) (23)
Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome (2015) (23)
Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. (2003) (23)
Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: An in vitro model of down syndrome (2004) (23)
Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition. (2014) (23)
Construction of Mouse A9 Clones Containing a Single Human Chromosome (X/Autosome Translocation) via Micro‐cell Fusion (1989) (23)
The use of chromosome-based vectors for animal transgenesis (2002) (23)
Meiotic disjunction in t(14;15)6ca heterozygotes and fate of chromosomally unbalanced gametes in embryonic development. (1975) (22)
Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines (2002) (22)
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans (2018) (22)
Isolation and mapping of 186 new DNA markers on human chromosome 1. (1991) (22)
Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome (2006) (22)
Functional evidence for the presence of tumor suppressor gene on chromosome 10p15 in human prostate cancers (2001) (22)
A gene that regulates DNA replication in response to DNA damage is located on human chromosome 4q. (1995) (22)
Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy. (2018) (21)
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism (2019) (21)
Elevated apoptosis in pre-mature neurons differentiated from mouse ES cells containing a single human chromosome 21. (2002) (21)
Establishment of a novel immortalized cell line from ataxia telangiectasia fibroblasts and its use for the chromosomal assignment of radiosensitivity gene. (1990) (21)
Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance. (2013) (21)
Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21. (2000) (21)
Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan (2014) (21)
Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer. (2000) (20)
Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein (1993) (20)
Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation (2015) (20)
Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32. (2004) (20)
Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. (1995) (20)
A summary of cytogenetic, morphologic, and clinical data on t(8q - ;21q+) and t(15q + ;17q-) translocation leukemias in Japan. (1982) (20)
A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. (2011) (20)
Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector. (2008) (20)
Integration-free and stable expression of FVIII using a human artificial chromosome (2011) (19)
CHROMOSOMAL 6q- ANOMALY IN ACUTE LYMPHOBLASTIC LEUKÆMIA (1976) (19)
Heat-regulated production and secretion of insulin from a human artificial chromosome vector. (2006) (18)
A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning (2005) (18)
Decreased Pulmonary Function in School Children in Western Japan after Exposures to Asian Desert Dusts and Its Association with Interleukin-8 (2015) (18)
Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. (1992) (17)
Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique. (2017) (17)
Dual-Color Fluorescence Imaging to Monitor CYP3A4 and CYP3A7 Expression in Human Hepatic Carcinoma HepG2 and HepaRG Cells (2014) (17)
Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics. (2018) (17)
Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion (2008) (17)
Transchromosomic technology for genomically humanized animals. (2020) (17)
Determination of the chromosomal site for the human radiosensitive ataxia telangiectasia gene by chromosome transfer. (1991) (17)
Suppression of X-ray-induced chromosome aberrations in ataxia telangiectasia cells by introduction of a normal human chromosome 11. (1992) (17)
Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis (2015) (17)
Telomerase activity correlates with histo‐pathological factors in uterine endometrial carcinoma (1999) (16)
Telomerase‐independent senescence of human immortal cells induced by microcell‐mediated chromosome transfer (1999) (16)
Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells (2020) (16)
Chromosome banding patterns in Ehrlich and Yoshida ascites tumors. (1974) (16)
Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models (2018) (16)
PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription (2016) (15)
An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. (2002) (15)
The Role of Chromosome 18 Abnormalities in the Progression of Pancreatic Adenocarcinoma (2004) (15)
Use of real-time RT-PCR for the detection of allelic expression of an imprinted gene. (2003) (15)
Chronic myelogenous leukemia with a complex Ph1 translocation in an XYY male. (1984) (15)
Epigenetic reprogramming of the human H19 gene in mouse embryonic cells does not erase the primary parental imprint (1998) (15)
Normal Human Chromosome 1 Carries Suppressor Activity for Various Phenotypes of a Kirsten Murine Sarcoma Virus‐transformed NIH/3T3 Cell Line (1990) (15)
Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis (2004) (15)
Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. (2004) (15)
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates. (2017) (15)
Chromosome 22 complements apoptosis in Fas-and TNF-resistant mutant UK110 cells. (1996) (15)
Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans (2016) (15)
Multiple chromosomes carrying tumor suppressor activity, via microcell-mediated chromosome transfer, for various tumor cell lines. (1989) (14)
The transfer of human artificial chromosomes via cryopreserved microcells (2013) (14)
New Vectors for Gene Delivery: Human and Mouse Artificial Chromosomes (2013) (14)
Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3. (2015) (14)
Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. (1995) (14)
Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice (2017) (14)
Effects of Tritrichomonas muris on the mouse intestine: a proteomic analysis. (2009) (14)
Human monochromosome hybrid cell panel characterized by FISH in the JCRB/HSRRB (2004) (14)
A new mouse model for Down syndrome. (2003) (13)
Isolation and mapping of 75 new DNA markers on human chromosome 3. (1991) (13)
Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies (2017) (13)
MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach (2007) (13)
Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice (2018) (13)
A kidney injury molecule‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells (2016) (13)
Identification and characterization of an imprinted antisense RNA ( MESTIT 1 ) in the human MEST locus on chromosome 7 q 32 (2002) (13)
Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study. (2012) (13)
Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines. (2004) (12)
Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors. (2015) (12)
The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes. (1996) (12)
A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells. (2007) (12)
Maintenance and Function of a Plant Chromosome in Human Cells. (2016) (12)
Ordering of human chromosome 3p markers by radiation hybrid mapping. (1992) (12)
Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement (2017) (12)
Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering (2010) (12)
CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells (2017) (12)
Antigen-mediated growth control of hybridoma cells via a human artificial chromosome. (2007) (12)
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals (2021) (11)
Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate (2016) (11)
Establishment of different clonal strains from a human sarcoma of the stomach: tumorigenic heterogeneity in athymic nude mice. (1983) (11)
Induction of cellular senescence in a telomerase negative human immortal fibroblast cell line, LCS-AF.1-3, by human chromosome 6. (2002) (11)
Chromosomes and causation of human cancer and leukemia. X. Banding patterns in cancerous effusions. (1975) (11)
A new method of microcell-mediated transfer of human artificial chromosomes using a hemagglutinating virus of Japan envelope (2006) (11)
Characterization of extramedullary tumors in a case of Ph-positive chronic myelogenous leukemia: possible involvement of immature T lymphocytes. (1985) (11)
Suppression of endometrial carcinoma cell tumorigenicity by human chromosome 18 (1995) (11)
Cloning and polymerase chain reaction-single-strand conformation polymorphism analysis of anonymous Alu repeats on chromosome 11. (1992) (11)
Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector (2015) (11)
Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells. (1994) (11)
Complementation analysis of the murine scid cell line. (1995) (11)
Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance (2009) (11)
Transmission of Genomic Instability from a Single Irradiated Human Chromosome to the Progeny of Unirradiated Cells (2007) (10)
Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers (2005) (10)
Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9 (2018) (10)
Genetic heterogeneity of chromosome 11 associated with tumorigenicity in HeLa D98-OR cells. (1995) (10)
Extrinsic factors derived from mouse embryonal carcinoma cell lines maintain pluripotency of mouse embryonic stem cells through a novel signal pathway (2009) (10)
Chromosome 3p deletion in a renal cell carcinoma cell line established from a patient with von Hippel-Lindau disease. (1993) (10)
Current advances in microcell-mediated chromosome transfer technology and its applications. (2020) (10)
Increased Frequencies of Gene and Chromosome Mutations after X‐Irradiation in Mouse Embryonal Carcinoma Cells Transfected with the bcl‐2 Gene (2000) (10)
The effect of caffeine on p53-dependent radioresponses in undifferentiated mouse embryonal carcinoma cells after X-ray and UV-irradiations. (2000) (10)
Restoration of the cholesterol metabolism in 3T3 cell lines derived from the sphingomyelinosis mouse (spm/spm) by transfer of a human chromosome 18 (1993) (10)
Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer. (1995) (9)
Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor. (1996) (9)
Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice. (2012) (9)
PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia (2013) (9)
Suppression of metastasis of rat prostate cancer by introduction of human chromosome 13. (2002) (9)
Girl with monosomy 1p36 and Angelman syndrome due to unbalanced der(1) transmission of a maternal translocation t(1;15)(p36.3;q13.1) (2004) (9)
Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the Pancreas (2011) (9)
Transformation of Mammalian Cells in Culture by Asbestos and Other Mineral Dusts: A Mechanism Involving Chromosomal Mutation (1985) (9)
A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing (2021) (9)
Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy (2015) (8)
A 14q+ chromosome in a malignant lymphoma in a patient with Down's syndrome. (1981) (8)
Identification of a ≦600-kb region on human chromosome 1q42.3 inducing cellular senescence (2003) (8)
Simple purification of human chromosomes to homogeneity using muntjac hybrid cells (1994) (8)
Lessons learned from studies on tumor suppression by microcell-mediated chromosome transfer. (1991) (8)
Cellular senescence of a human bladder carcinoma cell line (JTC-32) induced by a normal chromosome 11. (2000) (8)
Establishment and characterization of an immature epithelial cell line (ENU-T-1) derived from a rat nephroblastoma (1989) (8)
Growth and transformation suppressor genes for BHK syrian hamster cells on human chromosomes 1 and 11 (1992) (8)
Reversal of methylation tolerance by transfer of human chromosome 2. (1997) (8)
hTR repressor-related gene on human chromosome 10p15.1 (2001) (8)
Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci (2020) (8)
Banding profiles of LTR of human endogenous retrovirus HERV-A in 24 chromosomes in somatic cell hybrids. (1992) (7)
LRRTM1 protein is located in the endoplasmic reticulum (ER) in mammalian cells (2007) (7)
Karyotype and heterochromatin pattern of the field mouse,Apodemus argenteus Temminck (1975) (7)
Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT). (2010) (7)
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation (2020) (7)
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis (2019) (7)
TO JMG Genomic imprinting of PPP 1 R 9 A encoding neurabin I in skeletal muscle and extraembryonic tissues (2004) (7)
Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene. (2009) (7)
Meganuclease-based artificial transcription factors. (2020) (7)
Development of evaluation system for bioactive substances using human artificial chromosome-mediated osteocalcin gene expression. (2010) (7)
Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity. (1991) (7)
Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase. (2017) (7)
Cytogenetic and hematologic findings in acute myelogenous leukemia, M2 according to the FAB classification. (1982) (7)
Murine myeloid leukemia: colony formation in vitro. (1978) (7)
Cytogenetic and in vitro culture studies on chronic myelomonocytic leukemia (1984) (6)
Letter: 8-21 translocation and missing sex chromosomes in acute leukaemia. (1974) (6)
A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1→q11.1 (2004) (6)
Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity (2016) (6)
Studies of Tumor Suppressor Genes via Chromosome Engineering (2015) (6)
Telomerase activity and microsatellite instability in colorectal cancer and adenoma. (1998) (6)
Delayed onset of beating and decreased expression of T-type Ca2+ channel in mouse ES cell-derived cardiocytes carrying human chromosome 21. (2006) (6)
Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced. (2001) (6)
An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells (2019) (6)
Gene dosage imbalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons. (2011) (6)
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome (2020) (6)
Changes in expression of imprinted genes following treatment of human cancer cell lines with non-mutagenic or mutagenic carcinogens. (2008) (6)
Chromosomes and causation of human cancer and leukemia. XXI. Cytogenetically unusual cases of leukemia. (1976) (6)
A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells (2014) (5)
Further Karyological Evidence for Contageousness and Common Origin of Canine Venereal Tumors (1974) (5)
A human gene that restores the DNA-repair defect in SCID mice is located on 8 pl l . 1 > qll . 1 (5)
Human artificial chromosome vectors meet stem cells (2006) (5)
Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome (2007) (5)
Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification (2021) (5)
Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells (2014) (5)
Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8 (2015) (5)
Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice (2021) (5)
Human complement regulatory proteins expressed on mouse A9 cells containing a human chromosome 1. (1991) (5)
Mutation and Neoplastic Transformation (1988) (4)
A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region (2014) (4)
Chromosomal banding of cultured T and B lymphocytes (1975) (4)
Cysteine-rich protein 61 suppresses cell invasion via down-regulation of matrix metalloproteinase-7 expression in the human gastric carcinoma cell line MKN-45. (2010) (4)
Effects of duration of electric pulse on in vitro development of cloned cat embryos with human artificial chromosome vector. (2016) (4)
Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo (2019) (4)
Construction of 110 cosmid markers and a 4.5-Mb YAC contig on human chromosome 8p12-q11. (1995) (4)
A non-mosaic humanized mouse model of Down syndrome, trisomy of a nearly complete long arm of human chromosome 21 in mouse chromosome background (2019) (4)
Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer (2021) (4)
Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer. (2019) (4)
Genetic regulation of telomerase in a multiple pathways model to cellular senescence. (1996) (4)
Multiple human chromosomes carrying tumor‐suppressor functions for the mouse melanoma cell line B16‐F10, identified by microcell‐mediated chromosome transfer (2002) (4)
Distribution of human endogenous retroviral RTVL-H2 LTR sequences among human chromosomes. (1997) (4)
Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line. (2012) (4)
Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling (2020) (4)
A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity (2016) (4)
Multiple expression cassette exchange via TP901‐1, R4, and Bxb1 integrase systems on a mouse artificial chromosome (2017) (4)
Brief Report: Lessons Learned from Studies on Tumor Suppression by Microcell-Mediated Chromosome Transfer (1991) (4)
A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein–protein interactions mediated by G protein-coupled receptors (2018) (4)
A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features. (2022) (4)
Construction of human–rodent hybrid cells containing single transferable fragments of human chromosome 10p (2000) (4)
Chronic myelogenous leukemia with translocations (3q-;9q+) and (17q-;22q+). Possible crucial cytogenetic events in the genesis of CML (2004) (3)
Repression of hTERT transcription by the introduction of chromosome 3 into human oral squamous cell carcinoma. (2015) (3)
Cytogenetic evidence for and frequency of adjacent-2 disjunction in murine t(1;13)70h male heterozygotes. (1976) (3)
Hybridization of Testis-Derived Stem Cells with Somatic Cells and Embryonic Stem Cells in Mice1 (2012) (3)
Deleted in Esophageal Cancer 1(DEC1) Is Down-Regulated and Contributes to Migration in Head and Neck Squamous Cell Carcinoma Cell Lines (2010) (3)
Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay. (2016) (3)
An amino-terminally truncated p53 protein expressed in a human choriocarcinoma cell line, CC1. (1995) (3)
Gene expressions of transferred human chromosome 8 in mouse cell lines. (1997) (3)
Characterization of experimental rat nephroblastoma and its cell line. (1992) (3)
Panel of human cell lines with human/mouse artificial chromosomes (2022) (3)
Cloneless genomic DNA analysis: an efficient and simple methods for de novo genomic sequencing projects and gap filling. (2005) (2)
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells (2021) (2)
[Telomere, cellular senescence and transformation]. (1993) (2)
Bi-HAC vector system toward gene and cell therapy. (2014) (2)
Non-disjunction of an unusual X chromosome. (1976) (2)
742. Human Artificial Chromosome (HAC) Vector Provides Long-Term Therapeutic Transgene Expression in Normal Human Primary Fibroblasts (2005) (2)
Evidence for divergence of DNA methylation maintenance and a conserved inhibitory mechanism from DNA demethylation in chickens and mammals (2021) (2)
Dinucleotide repeat polymorphisms at D16S467 and D16S468 and D5S560. (1993) (2)
[Challenge toward gene-therapy using iPS cells for Duchenne muscular dystrophy]. (2012) (2)
Use of Microcell Hybrids for Analysis of the 11q23 Region and Improved Localization of the A-T Group A/C Genes (1993) (2)
Increased actin cable organization after single chromosome introduction: Association with suppression of in vitro cell growth rather than tumorigenic suppression (1994) (2)
Frame-shift mutation and reduced transcript of p53 gene in a renal cell carcinoma cell line, RCC23. (1995) (2)
Generation of Chromosome‐Specific Monoclonal Antibodies Using In Vitro–Differentiated Transchromosomic Mouse Embryonic Stem Cells (2005) (2)
Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome (2004) (2)
Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants (1993) (2)
Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas (2009) (2)
SEXUAL DIFFERENCES IN MEIOTIC DISJUNCTION OF MURINE T(1; 13)70H TRANSLOCATION HETEROZYGOTES (1978) (2)
Long-term and dependent growth of human leukemic blast cells with granulocyte-macrophage differentiation in vitro. (1983) (2)
Real‐time fluorometric evaluation of hepatoblast proliferation in vivo and in vitro using the expression of CYP3A7 coding for human fetus‐specific P450 (2020) (2)
[Studies on tumor suppressor genes by gene/chromosome transfer]. (1995) (1)
Narrowed abrogation of the Angelman syndrome critical interval on human chromosome 15 does not interfere with epigenotype maintenance in somatic cells (2005) (1)
[Proteomics and epigenetics learned from Down syndrome model mouse]. (2004) (1)
Generation of a panel of radiation-reduced hybrids containing human 11q22-23 fragments bearing aHPRT selective marker: Identification of hybrids carrying various subregions around the ataxia-telangiectasia locus (1996) (1)
[Clinical significance of telomerase activity in precancerous lesion of the liver (adenomatous hyperplasia)]. (1998) (1)
Targeted activation and repression of imprinted genes by synthetic zinc finger transcription factors. (2003) (1)
Creation of Hybridomas from Mice Expressing Human Antibody by Introduction of a Human Chromosome (1999) (1)
Introduction of a normal chromosorne 8 into Werner syndrome cells by microcell fusion (1993) (1)
Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology (2017) (1)
Cosmids and transcribed sequences from chromosome 11q23 (1995) (1)
[Tumor-suppressor genes]. (1991) (1)
Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice (2001) (1)
A comparative banding analysis of chromosomes in three species of lemurs (Primates,Lemuridae) (1975) (1)
Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells. (2018) (1)
A normal human chromosome 3 suppresses tumorigenicity of human cervical carcinoma cell line, SiHa (1995) (0)
[Development of basophilic leukemia with trisomy 8 and atypical erythroblastosis in a patient with a history of aplastic anemia 22 years earlier]. (1982) (0)
A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges (2015) (0)
Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells. (1994) (0)
Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell (1997) (0)
Analysis of AT gene loci for colplelentation groups A and C. (1993) (0)
DOWN ' S SYNDROME IN RECIPROCAL TRANSLOCATIONS INVOLVING A G GROUP CHROMOSOME Chromosomes in Offspring of Balanced (0)
Difference in interleukin-8 transcriptional activity induced in THP-G8 cells by particulate matter collected in winter and summer in western Japan. (2015) (0)
Loss of heterozygosity at a cellular senescence locus on human chromosome 2 in various types of tumors (1998) (0)
Induction of CYP3A in double humanized mice of PXR and CYP3A Corresponding author (2019) (0)
991. Construction of a Novel Human Artificial Chromosome and Its Use for Gene Delivery (2004) (0)
Radiation-Induced Delayed Chromosome Aberrations (2003) (0)
, 1 Asako Nakamura / 1 Hiroshi Tauchi , 1 Satoru Endo , ' (2017) (0)
gene.U2af1-rs1 is a neomorphic imprinted (2013) (0)
Reply to the letter of Kayashima et al. (2003) (0)
Construction of luciferase complementation assay for G protein-coupled receptor activation using mouse artificial chromosomes (2017) (0)
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes (2022) (0)
Combination of functional genomics approaches and microarray analyses to define candidate senescence genes (2001) (0)
Potential Usage of Human Artificial Chromosome for Regenerative Medicine (2016) (0)
Two cases of acute myelogenous leukemia with high terminal deoxynucleotidyl transferase activity responding to vincristine-prednisolone treatment with complete remission. (1981) (0)
Targeted modification of human chromosome in the chicken pre-B cell line, DT40. (1998) (0)
Analysis of Group A/C AT Gene Loci within Chromosome 11q23 Region (1994) (0)
Twelve simple repeat sequence polymorphisms on chromosomes 4, 11, 16 and 21. (1994) (0)
Region specific differentiation of ES cells into forebrain neural progenitors via a dual-monitor HAC (2017) (0)
P25 25 WP – CORRECTION OF HYPER-RADIOSENSITIVITY IN ATAXIA TELANGIECTASIA CELLS BY THE INTRODUCTION OF NORMAL HUMAN CHROMOSOME 11 (1991) (0)
Chimeric animal and method for its manufacture (1996) (0)
65 Suppression of tumorigenicity by introduction of normal human chromosome 11 into HeLa sublines. (1990) (0)
Analysis of Nucleolus Organizing Regions on chromosomes in Japanese Sika Deer (Cervus nippon) by fluorescence in situ hybridization using human 28S rRNA gene as a probe (2000) (0)
[A case of erythroleukemia with marked chromosomal abnormality complicated with Pneumocystis carinii pneumonitis (author's transl)]. (1980) (0)
[Telomerase and cancer]. (1998) (0)
P31-16New projects in Japan to alternative methods for repeated dose oral toxicity studies (2012) (0)
Tedesco Ameliorates Muscular Dystrophy Mediated Transfer of a Human Artificial Chromosome − Stem Cell (2011) (0)
Abstract 3310: Human artificial chromosome (HAC) vector with a conditional centromere for correction of human genetic deficiencies. (2013) (0)
S081 Loss of Imprinting of PEG1/MEST, IGF2 in Head and Neck Cancer (2006) (0)
Unstable nature of the X-irradiated human chromosome in unirradiated mouse m5S cells (2002) (0)
1053. Functional Restoration of a Genetic Defect in Multipotent Germline Stem Cells by Human Artificial Chromosome Containing a Genomic Insert (2006) (0)
A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region (2014) (0)
Hypermetabolism in mice carrying a near complete human chromosome 21 (2023) (0)
996. Application of a Novel Human Artificial Chromosome (HAC) Vector to Gene Therapy Aimed at Erythropoietin (EPO) Replacement (2004) (0)
Development of investigation to determine the cause of disease and therapeutics by chromosome medical engineering (2017) (0)
Reconstructing chromosomes : Functional studies using genomic engineering(Symposium : Manipulating Chromosomes)(Abstracts of the 52nd Annual Meeting of the Society of Chromosome Research) (2001) (0)
Breast Cancers Tumor Suppressor Gene in which the Function Is Lost in , an Imprinted ARHI Aberrant Methylation and Silencing of Updated (2003) (0)
Radiation induction of p53 in cells from Nijmegen Breakage Syndrome and functional mapping of the underlying gene at 8q21 (1998) (0)
Examination of radiosensitivity of undifferentiated mouse teratocarcinoma cells by analyzing apoptosis and cell cycle check points (1998) (0)
The functional role of long non-cording RNA KCNQ1OT1/LIT1 in colorectal cancer (2016) (0)
Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate (2023) (0)
Epigenetic regulation plays a role in the process of cellular differentiation (2007) (0)
Screening for functional tumor suppressor activity in pancreatic cancer. (2004) (0)
PCR based polymorphisms for D14S242, D14S246, D14S241, D14S243, D14S244 and D14S245. (1993) (0)
Towards the Extension of Life-Span of a Human Somatic Stem Cells Using a Human Artificial Chromosome Carrying a Conditional Centromere (2009) (0)
nitrosoguanidine N-nitro-′ N-Methyl-N Transformed with Progression to Immortality in Rat Tracheal Epithelial Cells Nonrandom Chromosome Alterations That Correlate with Updated (2006) (0)
[A family with a sister and brother affected by acute leukemia (author's transl)]. (1982) (0)
WAF1 induction and HPV infection as determinants of radiosensitivity in human cervical cancer (1997) (0)
Complementation of radioresistant DNA synthesis following γ-irradiation does not have an effect on cell survival, chromosomal abberations, and mutability in rodent cells (1996) (0)
19 Suppression of tumorigenicity by transfer of a normal chrmosome 3 or 11 into a cervical cancer cell line, SiHa. (1991) (0)
Instability of a Human Chromosome Exposed to Radiation in Unirradiated Mouse Cells (2002) (0)
O 101 : Identification of chromosome corresponding to genetic linkage group 1 and sequencing the chromosome DNA in Japanese eel ( Anguilla japonica ) * (2017) (0)
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome (2022) (0)
S01-2 Viral Pathogenesis in Humanized Mice S01-1 Maintenance and differentiation of human stem cells in NOG mice (2009) (0)
[Studies of genomic imprinting using mouse cells containing a human chromosome]. (1998) (0)
642. In Vitro Rescue of Radiosensitive Phenotype Using a Novel Human Artificial Chromosome (HAC) Vector Containing DNA-PKcs Gene (2004) (0)
A case of terminal deoxynucleotidyl transferase- and Philadelphia chromosome-positive acute leukemia with heterogenous blasts, which responded poorly to vincristine and prednisolone therapy. (1983) (0)
Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models (2017) (0)
Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region. (1997) (0)
The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2. (1996) (0)
Chromosome-wide discovery of imprinted and differentially expressed genes for disease study. (2002) (0)
[A case of chronic myelogenous leukemia with a pericentric inversion of the heterochromatic region of chromosome No. 1 (author's transl)]. (1982) (0)
[Studies on tumor suppressor genes via microcell fusion]. (1990) (0)
O 002-S A new strategy for gene knockin in Xenopus laevis using Platinum TALENs (2014) (0)
Human artificial chromosome-mediated genetic correction of human dystrophic skeletal muscle progenitors for the autologous cell therapy of Duchenne muscular dystrophy (2015) (0)
Chromosomal instability induced by ionizing radiation (2009) (0)
Involvement of Telonomic Instability in the Formation of Delayed Chromosome Aberrations Induced by Radiation (2001) (0)
Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation (2015) (0)
The effect of Cyp3a deficiency on androgen response and lipid synthesis in mouse prostate (2014) (0)
iPS cells and human artificial chromosomes: towards a genomic integration-free therapy for Duchenne muscular dystrophy (2016) (0)
[A case of Ph1-positive chronic myelogenous leukemia with missing Y (author's transl)]. (1978) (0)
Creation of Mice Expressing Human Antibody by Introduction of a Human Chromosome (1998) (0)
643 A New Chromosome 14-based Human Artificial Chromosome (HAC) Vector System for Efficient Transgene Expression in Human Primary Cells (2012) (0)
Radiation-induced genomic instability triggered by telomere dysfunction (2003) (0)
[Microcell-mediated chromosome transfer--identification of chromosomes carrying a tumor-suppressor function]. (1990) (0)
The role of Aneupoloidy in Tumorigenesis (2009) (0)
Two types of human artificial chromosome vectors (2013) (0)
Establishment of High Throughput Toxicity Testing Systems Using Cultured Cells(NEDO Project) (2008) (0)
Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model (2023) (0)
Human artificial chromosome-mediated strategies for stem cell-based therapy of muscular dystrophy (2015) (0)
Author response: A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21 (2020) (0)
The Effect of DNA Repair Defects on the Induction of Delayed Chromosome Aberrations by Radiation (2001) (0)
Keisuke Goto et al (2021) (0)
Telomeric instability in chromosomes exposed to ionizing radiation (2004) (0)
A method for rapid and simple collection of intact plasmid toward identification of specific DNA-bound proteins using iChIP technology (2016) (0)
Establishment of cell line derived from the patient with Nijmegen breakage syndroue and the genetic complementation with Ataxia telangiectasia disease. (1993) (0)
Subchromosomal Mapping of a Putative Transformation Suppressor Gene on Human Chromosome 1 (1995) (0)
[Significant correlation of telomerase activity in lung adenocarcinomas with cell differentiation and chromosome aberration]. (1998) (0)
Isolation andMappingof68RFLPMarkers on Human Chromosome6 (1992) (0)
C-2 Developmental analysis of cardiovascular system in chimeric mouse fetuses with human chromosome 21. (2000) (0)
Construction of Model Mice Which Have Humanized Immune System. (1998) (0)
High susceptibility to the induction of genetic instability by radiation in DNA repair-deficient cells (2003) (0)
The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome features (2021) (0)
[An autopsied case of CML in which masked Ph1 was observed following myeloid crisis through lymphoid crisis (author's transl)]. (1981) (0)
423 Identification of a chromosome controls various transformed phenotypes of a choriocarcinoma cell line CCl by microcell-mediated chromosome transfer. (1990) (0)
Possibility of DHFR Gene Amplification by Arsenic (1993) (0)
Growth Control of Mammalian Cells via a Human Artificial Chromosome Harboring a Chimeric Receptor (2010) (0)
Mouse A9 cells containing a single human chromosome 2 tagged with a dominant selectable marker gene in different regions (1996) (0)
[Toward gene and cell therapy using human artificial chromosome]. (2011) (0)
MPTP neurotoxicity is enhanced by a restraint stress in C57BL/6 mice (2007) (0)
[Telomerase repressor genes]. (1996) (0)
[Use of microcell-hybrid for genomic analyses]. (1993) (0)
Toward safe and effective gene and cell therapies using human artificial chromosomes and stem cells (2013) (0)
Panel of human cell lines with human/mouse artificial chromosomes (2022) (0)
Human Cell Line Panel With Human/Mouse Artificial Chromosomes for Functional Analyses of Desired Genes (2021) (0)
Enhanced induction of mutation by X-irradiation in Werner syndrome cells (2002) (0)
In Focus (2019) (0)
Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for (2012) (0)
Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism (2022) (0)
Gene locus of Nijmegen Breakage Syndrome and the biological similarity to Ataxia-telangiectasia. (1997) (0)
[Telomerase activity and genomic instability in colorectal cancers]. (1998) (0)
Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice (2018) (0)
Production of a Human Cell Line with a Plant Chromosome. (2018) (0)
Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis (2017) (0)
Phenotypic Reversion of an X-Ray-Induced Transformant of Mouse m5S by Introduction of a Human Chromosome 11 (2001) (0)
P25 24 WP – CHROMOSOMAL ASSIGNMENT OF RADIOSENSITIVITY GENE BY THE USE OF CHROMOSOME TRANSFER INTO ATAXIA TELANGIECTASIA CELLS (1991) (0)
Studies on Tumor-suppressor Genes by Monochromosome Transfer (1991) (0)
Functional genomics by chromosome engineering (2001) (0)
Correction: A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells (2014) (0)
P25 23 WP – REDUCED FREQUENCY OF CHROMOSOME ABERRATIONS INDUCED WITH X-RAYS IN ATAXIA TELANGIECTASIA CELLS BY THE INTRODUCTION OF CHROMOSOME 11 (1991) (0)
Hematopoiesis of Human Induced Pluripotent Stem Cells Derived From Patients with Down Syndrome (2010) (0)
New perspectives in transgenesis. (2001) (0)
AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Gene(s) (1993) (0)
[A case of Philadelphia chromosome positive acute lymphoblastic leukemia]. (1984) (0)
Development of multi-color luciferase assay system using artificial chromosome vector (2016) (0)
Evaluation of the drug-mediated induction of metabolic enzymes using a novel CYP3A/PXR humanized mouse to predict intestinal pharmacokinetics (2018) (0)
CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells (2017) (0)
Functional Complementation Studies with X-ray-sensitive Mutants of Chinese Hamster Cells Closely Resembling Ataxia-telangiectasia Cells. (1994) (0)
32 Introduction of a normal human chromosome 1 suppresses various transformed phenotypes of an uterine endometrial carcinoma cell line. (1989) (0)
Analysis of Mutations at the FANCC and FANCG genes in Japanese Fanconi anemia patients (1999) (0)
Genetic MappingUsingMicrocell-Mediat ed Chromosome Transfer Suggests a LocusforNijmegen Breakage Syndrome atChromosome 8q21-24 (1997) (0)
Identification of long non-coding RNA Xist associated protein complexes on a mouse artificial chromosome using the enChIP method. (2016) (0)
[Advantages and applications of human artificial chromosome vector]. (2010) (0)
The Examination of the Exclusion Mechanism of Apoptosis against the Cells with Unrepairable DNA Damage Using Undifferentiated Mouse Terarocarcinoma Cells (1999) (0)
Cancer and epigenetics – basic research and clinical implications: Joint Meeting of the Fourteenth International Symposium of the Hiroshima Cancer Seminar and the Eighth Meeting of the Tottori Bioscience Promotion Foundation, October 2004 (2005) (0)
CONSTRUCTION AND EVALUATION OF CYP3A-HAC MICE WITH THE HUMAN CYP3A CLUSTER FOR DRUG-DRUG INTERACTION STUDY (2008) (0)
Explorer Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression (2017) (0)
13. Suppression of Tumorigenicity in Uterine Endometrial Carcinoma via Cell Fusion (1988) (0)
The Role of DNA-PKcs Function on Induction of Genetic Instability by Radiation (2002) (0)
370 Alterations of cytoskeleton in human endometrial carcinome cells transferred by a chromosome #1. (1991) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Mitsuo Oshimura?

Mitsuo Oshimura is affiliated with the following schools: