Ronald Breaker
#167,141
Most Influential Person
American biochemist
Why Is Ronald Breaker Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ronald R. Breaker, Ph.D. is a Sterling Professor of Molecular, Cellular, and Developmental Biology at Yale University. He is best known for the discovery of riboswitches. His current research is focused on understanding advanced functions of nucleic acids, including the discovery and analysis of riboswitches and ribozymes.
Ronald Breaker's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression (2002) (1105)
- A DNA enzyme that cleaves RNA. (1994) (1079)
- Control of gene expression by a natural metabolite-responsive ribozyme (2004) (839)
- Gene regulation by riboswitches (2004) (795)
- Regulation of bacterial gene expression by riboswitches. (2005) (710)
- Genetic control by a metabolite binding mRNA. (2002) (687)
- Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP (2008) (681)
- Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria (2003) (675)
- An mRNA structure that controls gene expression by binding FMN (2002) (609)
- Importance of the Debye screening length on nanowire field effect transistor sensors. (2007) (608)
- Riboswitches and the RNA world. (2012) (545)
- Riboswitches as versatile gene control elements. (2005) (526)
- Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. (2004) (519)
- Adenine riboswitches and gene activation by disruption of a transcription terminator (2004) (493)
- The structural and functional diversity of metabolite-binding riboswitches. (2009) (492)
- Relationship between internucleotide linkage geometry and the stability of RNA. (1999) (485)
- New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control. (2004) (454)
- Prospects for riboswitch discovery and analysis. (2011) (445)
- Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group (1999) (444)
- The distributions, mechanisms, and structures of metabolite-binding riboswitches (2007) (444)
- A Glycine-Dependent Riboswitch That Uses Cooperative Binding to Control Gene Expression (2004) (440)
- The speed of RNA transcription and metabolite binding kinetics operate an FMN riboswitch. (2005) (438)
- An mRNA structure that controls gene expression by binding S-adenosylmethionine (2003) (421)
- Riboswitches as antibacterial drug targets (2006) (418)
- Metabolite-binding RNA domains are present in the genes of eukaryotes. (2003) (413)
- Control of alternative RNA splicing and gene expression by eukaryotic riboswitches (2007) (394)
- Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch (2006) (387)
- Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes (2010) (356)
- A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. (1995) (349)
- Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride (2012) (348)
- An mRNA structure in bacteria that controls gene expression by binding lysine. (2003) (340)
- An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger (2010) (329)
- Rational design of allosteric ribozymes. (1997) (314)
- Natural and engineered nucleic acids as tools to explore biology (2004) (313)
- In-line probing analysis of riboswitches. (2008) (309)
- Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes. (2004) (309)
- Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline (2007) (303)
- Engineering precision RNA molecular switches. (1999) (301)
- Riboswitch Control of Gene Expression in Plants by Splicing and Alternative 3′ End Processing of mRNAs[W][OA] (2007) (290)
- The kinetics of ligand binding by an adenine-sensing riboswitch. (2005) (276)
- Riboswitch diversity and distribution. (2017) (275)
- Genetic Control by Metabolite‐Binding Riboswitches (2003) (273)
- Structural basis of ligand binding by a c-di-GMP riboswitch (2009) (270)
- Tandem Riboswitch Architectures Exhibit Complex Gene Control Functions (2006) (250)
- Riboswitches in eubacteria sense the second messenger c-di-AMP (2013) (239)
- Engineered allosteric ribozymes as biosensor components. (2002) (237)
- 6S RNA is a widespread regulator of eubacterial RNA polymerase that resembles an open promoter. (2005) (233)
- Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria (2005) (229)
- Cleaving DNA with DNA. (1998) (221)
- A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain (2007) (220)
- Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine. (2005) (218)
- Antibacterial lysine analogs that target lysine riboswitches. (2007) (204)
- In Vitro Selection of Catalytic Polynucleotides. (1997) (201)
- R2R - software to speed the depiction of aesthetic consensus RNA secondary structures (2011) (198)
- A widespread self-cleaving ribozyme class is revealed by bioinformatics (2013) (192)
- In vitro selection of self-cleaving DNAs. (1996) (191)
- Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression (2009) (189)
- Computational design and experimental validation of oligonucleotide-sensing allosteric ribozymes (2005) (187)
- Immobilized RNA switches for the analysis of complex chemical and biological mixtures (2001) (185)
- An amino acid as a cofactor for a catalytic polynucleotide. (1998) (184)
- Ribozyme speed limits. (2003) (179)
- Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP (1999) (173)
- DNA aptamers and DNA enzymes. (1997) (162)
- A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism (2008) (155)
- Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling. (2008) (151)
- New classes of self-cleaving ribozymes revealed by comparative genomics analysis (2015) (150)
- Phosphorylating DNA with DNA. (1999) (148)
- Production of RNA by a polymerase protein encapsulated within phospholipid vesicles (1994) (145)
- Guanine riboswitch variants from Mesoplasma florum selectively recognize 2′-deoxyguanosine (2007) (135)
- Identification of Hammerhead Ribozymes in All Domains of Life Reveals Novel Structural Variations (2011) (130)
- DNA enzymes (1997) (130)
- Bacterial riboswitches cooperatively bind Ni(2+) or Co(2+) ions and control expression of heavy metal transporters. (2015) (124)
- Deoxyribozymes: new activities and new applications (2002) (122)
- Ligand binding and gene control characteristics of tandem riboswitches in Bacillus anthracis. (2007) (121)
- Nucleic acid molecular switches. (1999) (119)
- Deoxyribozymes: new players in the ancient game of biocatalysis. (1999) (117)
- Design and antimicrobial action of purine analogues that bind Guanine riboswitches. (2009) (114)
- The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches. (2008) (114)
- Altering molecular recognition of RNA aptamers by allosteric selection. (2000) (113)
- Capping DNA with DNA. (2000) (111)
- Allosteric nucleic acid catalysts. (2000) (111)
- Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria. (2008) (109)
- A variant riboswitch aptamer class for S-adenosylmethionine common in marine bacteria. (2009) (109)
- Characteristics of the glmS ribozyme suggest only structural roles for divalent metal ions. (2006) (108)
- New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes. (2011) (107)
- Riboswitches and Translation Control. (2018) (107)
- Small, highly active DNAs that hydrolyze DNA. (2013) (106)
- Metabolism of Free Guanidine in Bacteria Is Regulated by a Widespread Riboswitch Class. (2017) (104)
- Structural diversity of self-cleaving ribozymes. (2000) (104)
- A common speed limit for RNA-cleaving ribozymes and deoxyribozymes. (2003) (103)
- Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine. (2008) (97)
- Inventing and improving ribozyme function: rational design versus iterative selection methods. (1994) (97)
- Making Catalytic DNAs (2000) (97)
- Purine sensing by riboswitches (2008) (96)
- Bacterial aptamers that selectively bind glutamine (2011) (96)
- Characterization of a DNA-cleaving deoxyribozyme. (2001) (95)
- Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins (2013) (95)
- Unique glycine-activated riboswitch linked to glycine-serine auxotrophy in SAR11. (2009) (93)
- A Computational Pipeline for High- Throughput Discovery of cis-Regulatory Noncoding RNA in Prokaryotes (2007) (92)
- A eubacterial riboswitch class that senses the coenzyme tetrahydrofolate. (2010) (90)
- Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions (2017) (90)
- Cooperative binding of effectors by an allosteric ribozyme. (2001) (89)
- An ancient riboswitch class in bacteria regulates purine biosynthesis and one-carbon metabolism. (2015) (89)
- Emergence of a replicating species from an in vitro RNA evolution reaction. (1994) (89)
- Ligating DNA with DNA. (2004) (84)
- Eukaryotic TPP riboswitch regulation of alternative splicing involving long-distance base pairing (2013) (84)
- Control of bacterial exoelectrogenesis by c-AMP-GMP (2015) (83)
- Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization. (1999) (81)
- The expanding view of RNA and DNA function. (2014) (79)
- Biochemical Validation of a Second Guanidine Riboswitch Class in Bacteria. (2017) (76)
- Mechanism for allosteric inhibition of an ATP-sensitive ribozyme. (1998) (76)
- Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes. (2001) (76)
- The lost language of the RNA World (2017) (75)
- Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches (2009) (74)
- Molecular recognition of cAMP by an RNA aptamer. (2000) (67)
- Structural, functional, and taxonomic diversity of three preQ1 riboswitch classes. (2014) (66)
- Bioinformatic analysis of riboswitch structures uncovers variant classes with altered ligand specificity (2017) (66)
- Development and Application of a High-Throughput Assay for glmS Riboswitch Activators (2006) (65)
- A highly specialized flavin mononucleotide riboswitch responds differently to similar ligands and confers roseoflavin resistance to Streptomyces davawensis (2012) (65)
- Challenges of ligand identification for riboswitch candidates (2011) (64)
- Evidence for Widespread Gene Control Function by the ydaO Riboswitch Candidate (2010) (63)
- Mechanism for gene control by a natural allosteric group I ribozyme. (2011) (62)
- Identification of candidate structured RNAs in the marine organism 'Candidatus Pelagibacter ubique' (2009) (61)
- Complex Riboswitches (2008) (60)
- Extraordinary Structured Noncoding RNAs Revealed by Bacterial Metagenome Analysis (2009) (60)
- Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems (2018) (59)
- Riboswitches: from ancient gene-control systems to modern drug targets. (2009) (58)
- Examination of the catalytic fitness of the hammerhead ribozyme by in vitro selection. (1997) (57)
- Biochemical Validation of a Third Guanidine Riboswitch Class in Bacteria. (2017) (56)
- Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora (2015) (55)
- Characteristics of ligand recognition by a glmS self-cleaving ribozyme. (2006) (54)
- Engineered allosteric ribozymes that respond to specific divalent metal ions (2005) (54)
- An expanded collection and refined consensus model of glmS ribozymes. (2011) (53)
- Engineering high-speed allosteric hammerhead ribozymes (2007) (52)
- Biochemical analysis of pistol self-cleaving ribozymes (2015) (51)
- Molecular-recognition characteristics of SAM-binding riboswitches. (2006) (50)
- The power of riboswitches. (2007) (48)
- In vitro selection and characterization of cellulose-binding DNA aptamers (2007) (48)
- Catalytic DNA: in training and seeking employment (1999) (47)
- A Plant 5S Ribosomal RNA Mimic Regulates Alternative Splicing of Transcription Factor IIIA Pre-mRNAs (2009) (46)
- New Insight on the Response of Bacteria to Fluoride (2012) (44)
- Engineered allosteric ribozymes that sense the bacterial second messenger cyclic diguanosyl 5'-monophosphate. (2012) (44)
- Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria (2018) (43)
- A glutamine riboswitch is a key element for the regulation of glutamine synthetase in cyanobacteria (2018) (42)
- Continuous in vitro evolution of bacteriophage RNA polymerase promoters. (1994) (40)
- Identification of ligand analogues that control c-di-GMP riboswitches. (2012) (40)
- Rapid synthesis of oligoribonucleotides using 2′-O-(o-nitrobenzyloxymethyl)-protected monomers (1992) (40)
- Large Noncoding RNAs in Bacteria. (2018) (37)
- Biochemical analysis of hatchet self-cleaving ribozymes (2015) (37)
- Identification of a large noncoding RNA in extremophilic eubacteria (2006) (36)
- Finding Non-coding RNAs Through Genome-Scale Clustering (2007) (33)
- SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches (2018) (32)
- Genome-wide discovery of structured noncoding RNAs in bacteria (2019) (31)
- The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds (2016) (31)
- Fluoride enhances the activity of fungicides that destabilize cell membranes. (2012) (28)
- Challenges of ligand identification for the second wave of orphan riboswitch candidates (2018) (28)
- Self-Incorporation of coenzymes by ribozymes (2004) (27)
- Association of OLE RNA with bacterial membranes via an RNA–protein interaction (2011) (27)
- The Biology of Free Guanidine As Revealed by Riboswitches. (2017) (26)
- Bacterial Riboswitch Discovery and Analysis (2010) (25)
- RNA switches out in the cold. (2010) (25)
- Production of single-stranded DNAs by self-cleavage of rolling-circle amplification products. (2013) (25)
- Mechanistic Debris Generated by Twister Ribozymes. (2017) (24)
- Are engineered proteins getting competition from RNA? (1996) (24)
- A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer (2019) (24)
- A universal adapter for chemical synthesis of DNA or RNA on any single type of solid support (1995) (24)
- Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria (2020) (22)
- Former orphan riboswitches reveal unexplored areas of bacterial metabolism, signaling, and gene control processes (2020) (22)
- Selection in vitro of allosteric ribozymes. (2004) (21)
- Variant Bacterial Riboswitches Associated with Nucleotide Hydrolase Genes Sense Nucleoside Diphosphates. (2018) (21)
- Allosteric ribozymes sensitive to the second messengers cAMP and cGMP. (1999) (21)
- Integron attI1 Sites, Not Riboswitches, Associate with Antibiotic Resistance Genes (2013) (20)
- In Vitro Selection and Characterization of Cellulose-Binding RNA Aptamers Using isothermal Amplification (2008) (20)
- 4 Riboswitches and the RNA World (2006) (20)
- Evidence that the nadA motif is a bacterial riboswitch for the ubiquitous enzyme cofactor NAD+ (2019) (20)
- Synthesis and properties of adenosine oligonucleotide analogues containing methylene groups in place of phosphodiester 5'-oxygens. (1993) (20)
- Examination of the structural and functional versatility of glmS ribozymes by using in vitro selection (2006) (19)
- In vitro selection of kinase and ligase deoxyribozymes. (2001) (18)
- Small molecule fluoride toxicity agonists. (2015) (18)
- Mechanism and distribution of glmS ribozymes. (2012) (17)
- Substrate specificity and reaction kinetics of an X-motif ribozyme. (2003) (17)
- OLE RNA protects extremophilic bacteria from alcohol toxicity (2012) (16)
- Singlet glycine riboswitches bind ligand as well as tandem riboswitches (2016) (16)
- Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (16)
- In vitro selection of nucleic acid enzymes. (1999) (15)
- Rare variants of the FMN riboswitch class in Clostridium difficile and other bacteria exhibit altered ligand specificity (2018) (15)
- Imaginary Ribozymes. (2020) (14)
- A second riboswitch class for the enzyme cofactor NAD+ (2020) (12)
- A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation (2020) (12)
- The Biochemical Landscape of Riboswitch Ligands. (2022) (11)
- Numerous small hammerhead ribozyme variants associated with Penelope-like retrotransposons cleave RNA as dimers (2017) (11)
- Biochemical validation of a second class of tetrahydrofolate riboswitches in bacteria (2019) (11)
- Improved genetic transformation methods for the model alkaliphile Bacillus halodurans C‐125 (2011) (9)
- RNA Second Messengers and Riboswitches: Relics from the RNA World?: Some riboswitches and their ligands may be relics of signaling networks used when organisms relied on RNA instead of DNA and proteins (2010) (9)
- Employing a ZTP Riboswitch to Detect Bacterial Folate Biosynthesis Inhibitors in a Small Molecule High-throughput Screen. (2019) (8)
- Comprehensive discovery of novel structured noncoding RNAs in 26 bacterial genomes (2021) (7)
- A second RNA-binding protein is essential for ethanol tolerance provided by the bacterial OLE ribonucleoprotein complex (2018) (7)
- In vitro selection of allosteric ribozymes that sense the bacterial second messenger c-di-GMP. (2014) (7)
- Search for 5'-leader regulatory RNA structures based on gene annotation aided by the RiboGap database. (2017) (7)
- Gramicidin D enhances the antibacterial activity of fluoride. (2014) (6)
- Polynucleotide phosphorylase forms polymers from an ADP analog in which the 5' oxygen is replaced by a methylene group. (1990) (6)
- Riboswitches That Sense Cyclic Di-GMP (2010) (5)
- Gene expression control: Harnessing RNA switches (2005) (5)
- The case of the missing allosteric ribozymes (2021) (5)
- Ancient, giant riboswitches at atomic resolution (2012) (4)
- Disruption of the OLE ribonucleoprotein complex causes magnesium toxicity in Bacillus halodurans (2019) (4)
- Na+ riboswitches regulate genes for diverse physiological processes in bacteria (2022) (4)
- Variants of the guanine riboswitch class exhibit altered ligand specificities for xanthine, guanine, or 2′-deoxyguanosine (2022) (3)
- Minimonsters: Evolutionary Byproducts of In Vitro RNA Amplification (1994) (3)
- In vitro selection of deoxyribozymes with DNA capping activity. (1999) (3)
- Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes (2022) (2)
- A rare bacterial RNA motif is implicated in the regulation of the purF gene whose encoded enzyme synthesizes phosphoribosylamine (2020) (2)
- DIMPL: a bioinformatics pipeline for the discovery of structured noncoding RNA motifs in bacteria (2021) (2)
- In vitro selection of glmS ribozymes. (2009) (2)
- Witnessing the structural evolution of an RNA enzyme (2021) (2)
- Bacillus halodurans OapB forms a high-affinity complex with the P13 region of the noncoding RNA OLE (2020) (2)
- Tech.Sight. Molecular biology. Making catalytic DNAs. (2000) (2)
- Crystal structure of Bacillus halodurans OapB (native) at 1.2 A (2021) (1)
- Architectures and complex functions of tandem riboswitches (2022) (1)
- Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex (2021) (1)
- Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (crystal form II) (1)
- Selection for Catalytic Function with Nucleic Acids (2000) (1)
- RNA Science and its Applications—a look toward the future (2012) (1)
- Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (native, crystal form I) (1)
- Author response: A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer (2019) (1)
- Active enzyme dna molecules (1995) (0)
- Riboswitches as Genetic Control Elements (2006) (0)
- Chapter 8:The Structure and Action of glmS Ribozymes (2007) (0)
- Riboswitches: Regulators of modern and ancient metabolism (2006) (0)
- RNA World theory (2018) (0)
- The large, noncoding OLE RNA is associated with membrane biochemistry (2010) (0)
- Genetic Control by Metabolite-Binding Riboswitches (2003) (0)
- Reviewer List for 2002 (2002) (0)
- The expression of PBAN-like peptides in two ontogenetic stages of the commercial white shrimp Litopenaeus setiferus from the gulf of Mexico (2005) (0)
- Faculty Opinions recommendation of An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. (2002) (0)
- Additional file 7: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- Additional file 5: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- The chemical and enzymatic synthesis of RNA oligomers for the analysis of ribozyme structure and action (1992) (0)
- Author response: Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria (2018) (0)
- Self-Incorporation of Coenzymes by Ribozymes jou..A, ofMOLECULAR IEVOLUTION (1995) (0)
- Deoxyribozymes and Medical Innovation (2004) (0)
- Connecticut Academy of Science and Engineering Elects 50 New Members in 2014 (2014) (0)
- Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function (2022) (0)
- In vitro Selection of Catalytic Polynucleotides (1997) (0)
- PROSPECTS FOR RIBOZYME DISCOVERY AND ANALYSIS (2018) (0)
- Acides nucleiques en tant que catalyseurs (1998) (0)
- NASA / CR .-207595 L X . : ,6-. '-A DNA enzyme with MgZ +-dependent RNA phosphoesterase activity (0)
- Aptamers in Bioanalysis.Edited byMarco Mascini. Hoboken (New Jersey): Wiley. $125.00. xvii + 313 p. + 12 pl.; ill.; index. 978‐0‐470‐14830‐3. 2009. (2009) (0)
- Additional file 8: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- Nucleozymes a activite d'endonuclease (2001) (0)
- Additional file 9: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- Additional file 6: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- Additional file 4: of Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics (2017) (0)
- Riboswitches: Natural Metabolite‐binding RNAs Controlling Gene Expression (2006) (0)
- Chemical Exposure Study Leads : (2021) (0)
- Crystal structure of Bacillus halodurans OapB (iodine-derivative) at 1.0 A (2021) (0)
- Crystal structure of Bacillus halodurans OapB in complex with its OLE RNA target (crystal form I) (2021) (0)
This paper list is powered by the following services:
Other Resources About Ronald Breaker
What Schools Are Affiliated With Ronald Breaker?
Ronald Breaker is affiliated with the following schools:
