Sendurai Mani
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Sendurai Maniphilosophy Degrees
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Philosophy
Sendurai Mani's Degrees
- Doctorate Medicine University of Texas Southwestern Medical Center
Why Is Sendurai Mani Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sendurai A. Mani is an Indian-American oncologist and a Molecular Bilogist. He is a fellow of the American Association for the Advancement of Sciences, and Dean's Chair for Translational Oncology at Brown University Warren Alpert Medical School. He is also the associate director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School, Brown University. Previously, he was a co-director of Metastasis Research Center and co-director, the Center for Stem Cell & Developmental Biology, and a professor of Translational Molecular Pathology at MD Anderson Cancer Center.
Sendurai Mani's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells (2008) (8195)
- Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis (2004) (3762)
- Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. (2008) (1431)
- Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes (2010) (932)
- Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012) (834)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (778)
- Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers (2007) (577)
- CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer (2013) (574)
- Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming (2017) (458)
- Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. (2013) (383)
- The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies (2009) (369)
- Stability of the hybrid epithelial/mesenchymal phenotype (2016) (319)
- Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression (2011) (315)
- Exploring a new twist on tumor metastasis. (2006) (309)
- Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition (2013) (262)
- Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer (2010) (246)
- Epithelial‐Mesenchymal Transition‐Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells (2010) (244)
- Cell type-specific DNA methylation patterns in the human breast (2008) (235)
- FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. (2013) (235)
- Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. (2012) (227)
- Molecular mechanisms of metastasis in breast cancer—clinical applications (2010) (224)
- Breast cancer metastasis: challenges and opportunities. (2009) (213)
- Overexpression of Snail induces epithelial–mesenchymal transition and a cancer stem cell–like phenotype in human colorectal cancer cells (2012) (208)
- Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. (2007) (193)
- Epithelial–Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer (2012) (183)
- Expression of epithelial–mesenchymal transition‐inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy (2012) (150)
- Towards elucidating the connection between epithelial–mesenchymal transitions and stemness (2014) (149)
- Fluorinated Graphene Oxide; a New Multimodal Material for Biological Applications (2013) (149)
- Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model (2015) (145)
- Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties (2013) (117)
- Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis? (2018) (108)
- A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. (2018) (105)
- Synthesis of Fluorinated Graphene Oxide and its Amphiphobic Properties (2013) (103)
- Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype (2016) (102)
- Slug and Sox 9 Cooperatively Determine the Mammary Stem Cell State Citation (101)
- Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity. (2016) (99)
- GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer (2014) (95)
- Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells (2015) (89)
- Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein (2013) (81)
- N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration (2017) (81)
- Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition (2013) (79)
- A proteogenomic portrait of lung squamous cell carcinoma (2021) (77)
- Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy (2019) (75)
- Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients (2012) (75)
- Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing (2021) (74)
- Distinguishing mechanisms underlying EMT tristability (2017) (73)
- GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer (2019) (72)
- Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field. (2017) (70)
- A possible role for epigenetic feedback regulation in the dynamics of the epithelial–mesenchymal transition (EMT) (2019) (66)
- Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties (2016) (64)
- Hybrid 2D Nanomaterials as Dual‐Mode Contrast Agents in Cellular Imaging (2012) (64)
- Loss of breast epithelial marker hCLCA2 promotes epithelial to mesenchymal transition and indicates higher risk of metastasis (2011) (63)
- EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures (2020) (61)
- Alternative origins of stroma in normal organs and disease. (2012) (56)
- Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-Mesenchymal Transition (EMT) and DNA Methylation Changes (2014) (55)
- 3D Porous Graphene by Low‐Temperature Plasma Welding for Bone Implants (2016) (54)
- Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? (2016) (52)
- Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. (2016) (52)
- EMT-induced metabolite signature identifies poor clinical outcome (2015) (52)
- A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers (2017) (52)
- Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth (2016) (46)
- BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation (2013) (43)
- High hardness in the biocompatible intermetallic compound β-Ti3Au (2016) (41)
- EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. (2018) (40)
- The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states (2016) (39)
- Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia (2016) (35)
- A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome (2015) (34)
- The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. (2017) (34)
- Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT (2016) (33)
- Epidermal growth factor down‐regulates the expression of neutrophil gelatinase‐associated lipocalin (NGAL) through E‐cadherin in pancreatic cancer cells (2011) (30)
- Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition. (2013) (28)
- UDP-Glucose 6-Dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression (2019) (27)
- The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression (2019) (24)
- Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. (2015) (24)
- Three-Dimensional Porous Sponges from Collagen Biowastes. (2016) (23)
- FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition (2016) (22)
- Metal‐Free Dual Modal Contrast Agents Based on Fluorographene Quantum Dots (2017) (20)
- The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition (2017) (18)
- Erratum: Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudinlow and metaplastic breast cancer subtypes (Proceedings of the National Academy of Sciences of the United States of America (2010) 107:35 (15449-15454)) (2010) (18)
- Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge (2021) (16)
- Role of p38 MAP kinase in cancer stem cells and metastasis (2022) (15)
- pIgR: frenemy of inflammation, EMT, and HCC progression. (2011) (14)
- Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition (2021) (14)
- Vimentin and cytokeratin: good alone, bad together (2021) (14)
- Single-Cell Cloning of Breast Cancer Cells Secreting Specific Subsets of Extracellular Vesicles (2021) (13)
- Circulating Tumor Cells (CTCs) and Epithelial Mesenchymal Transition (EMT) in Breast Cancer: Describing the Heterogeneity of Microscopic Disease. (2009) (12)
- CD8+ T cells inhibit metastasis and CXCL4 regulates its function (2021) (11)
- Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’? (2022) (11)
- Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers (2018) (11)
- Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer (2021) (10)
- The importance of the epithelial-mesenchymal transition in breast cancer (2009) (8)
- Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer (2013) (8)
- Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition (2021) (7)
- Fluorescent Superparamagnetic Iron Oxide Core–Shell Nanoprobes for Multimodal Cellular Imaging (2012) (7)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers—4 (2015) (6)
- Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence (2022) (6)
- Forkhead Box Transcription Factors: Double-Edged Swords in Cancer (2022) (6)
- GD2 and GD3 synthase: novel drug targets for cancer therapy (2015) (6)
- A panel of emerging EMT genes identified in malignant mesothelioma (2021) (6)
- Whole exome sequencing of metaplastic breast cancer (MpBC): Effect of mutation status on survival. (2017) (5)
- Abstract 1598: LncRNA AK001796 as a therapeutic target in aggressive breast cancers (2016) (4)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers (2015) (4)
- Abstract 2080: Plasma membrane fluidity drives metastasis in breast cancer (2014) (4)
- Rules governing the creation of human tumor cells (2001) (4)
- GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer (2019) (4)
- Generation of stem-like cells via EMT; a new twist in cancer initiation and progression (2009) (4)
- Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakening (2021) (3)
- Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells. (2022) (3)
- Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs): The Traveling Metastasis (2017) (3)
- Abstract 3053: Stability and stemness of the hybrid epithelial-mesenchymal phenotype (2017) (2)
- Epithelial-to-mesenchymal transition, stem cells, and cancer progression (2011) (2)
- Acquisition of cancer stem cell properties during EMT requires cell division (2021) (2)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers—5 (2017) (2)
- Mechanisms of cancer metastasis. (2022) (2)
- HDAC3 at the fulcrum of an epithelial-mesenchymal balance. (2011) (2)
- Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition (2019) (2)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers—2 (2015) (1)
- Epithelial – Mesenchymal Transition and StemCell Markers in Patients with HER 2-Positive Metastatic Breast Cancer (2012) (1)
- Molecular Medicine in Practice Epithelial – Mesenchymal Transition and StemCell Markers in Patients with HER 2-Positive Metastatic Breast Cancer (2012) (1)
- Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients (2012) (1)
- Guidelines and definitions for research on epithelial–mesenchymal transition (2020) (1)
- RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives. (2023) (1)
- Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge (2021) (1)
- N-BLR, a primate-specific non-coding transcript, modulates the epithelial-to-mesenchymal transition and leads to colorectal cancer invasion and migration (2014) (1)
- Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression (2020) (1)
- Dextran Sulfate Polymer Wafer Promotes Corneal Wound Healing (2021) (1)
- P1-03-04: In-Vitro Characterization of a Breast Cancer Microenvironment with Epithelial-to-Mesenchymal Transition (EMT) Characteristics. (2011) (0)
- Méthode d'identification et d'utilisation d'agents ciblant les cellules souches cancéreuses (2009) (0)
- Abstract 5443: Modulating plasticity in aggressive variant prostate cancers (2020) (0)
- Abstract 1281: Endothelial cells promote the cancer stem cell phenotype of human colorectal cancer cells (2010) (0)
- Abstract IA006: EMT-induced tumor plasticity in cancer metastasis (2023) (0)
- Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity (2021) (0)
- In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay. (2022) (0)
- Enrichment of Cancer Stem Cells in a Tumorsphere Assay. (2022) (0)
- Ganglioside gd2 en tant que marqueur et cible sur des cellules souches cancéreuses (2013) (0)
- Effective models for antimetastatic therapies (2017) (0)
- Abstract 4040: Transcription factor Snail mediates EMT by altering vesicular trafficking protein Rab25 (2015) (0)
- Abstract B2-10: Systems biology reveals role of cholesterol homeostasis in breast cancer metastasis (2015) (0)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers-8 (2021) (0)
- Abstract 2300: Overexpression of Snail induces epithelial-mesenchymal transition and cancer stem cell-like phenotypes in CRC cells (2010) (0)
- Abstract A130: Immune regulation of EMT and metastatic competence in breast tumor progression (2016) (0)
- Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling. (2023) (0)
- Abstract A065: Modulating a cancer stem cell-specific signaling pathway to reverse the course of neuroendocrine prostate cancer (2018) (0)
- Erratum: The Non-Coding RNA Journal Club: Highlights on Recent Papers—4. Non-Coding RNA 2016, 2, 9 (2016) (0)
- FOXC2, Goosecoid, SIP1, Slug, Snail and Twist Induce EMT in Human Breast Cancer Cell Lines Through a Regulatory Network (2005) (0)
- Abstract 4674: Targeting cancer stem-cells in aggressive variant prostate cancers (2019) (0)
- Abstract B2-49: Coupled cellular decision-making of EMT and stemness: A bottom-up regulatory model (2015) (0)
- Abstract P6-02-02: Uridine diphosphate glucose dehydrogenase is required for hyaluronic acid production and breast cancer invasion (2017) (0)
- The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states (2016) (0)
- Abstract 5043: A vimentin binding small molecule (FiVe1) is a novel candidate to target CSC-rich TNBC (2020) (0)
- Abstract LB-193: Ganglioside GD2 identifies cancer stem cells and inhibition of GD2 biosynthesis by targeting GD3 synthase exerts antitumor effects (2012) (0)
- Verfahren zur Erkennung und Verwendung von auf Krebsstammzellen abzielenden Mitteln (2009) (0)
- Effective models for antimetastatic therapies. (2017) (0)
- EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures (2020) (0)
- Network motifs that stabilize the hybrid epithelial/mesenchymal phenotype (2016) (0)
- Abstract 5141: Determinants of metastatic competence in breast carcinoma: a role for immune cells (2016) (0)
- Distinguishing mechanisms underlying EMT tristability (2017) (0)
- Hybrid Epithelial-Mesenchymal Cancer Cells Exhibit Plasticity through Co-localization of Cytokeratin and Vimentin with Apoptotic Resistance (2021) (0)
- 900 Multipotent Mesenchymal Stromal Cells (MSC) - Evolving Role in Cancer and Leukemia Therapy (2011) (0)
- Abstract 2454: Identification of colorectal cancer stem cells from single cell RNA sequencing (2023) (0)
- Abstract A039: The role of long noncoding RNAs in epithelial to mesenchymal transition and cancer stem cells (2013) (0)
- Abstract 4065: Delineating the role of epithelial-mesenchymal transition in the generation and maintenance of prostate cancer stem cells (2015) (0)
- The Non-Coding RNA Journal Club: Highlights on Recent Papers—6 (2018) (0)
- Abstract 2314: Epithelial-mesenchymal transition derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells (2010) (0)
- Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer (2022) (0)
- Methodes de diagnostic, de prevention et de traitement de metastases cancereuses (2005) (0)
- Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition (2013) (0)
- Abstract 5008: Epidermal growth factor downregulates expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells (2011) (0)
- Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. (2022) (0)
- cancer metastatic progression and chromosomal instability in colon , a novel noncoding RNA mapping to 8 q 24 , underlies CCAT 2 Material Supplemental (2013) (0)
- A panel of emerging EMT genes identified in malignant mesothelioma (2022) (0)
- Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer (2020) (0)
- N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration (2017) (0)
- Abstract 3761: Regulation of metastasis by CD8 T lymphocytes (2019) (0)
- Abstract 2907: Exosome secretion is an inheritable property of cancer cells: Single-cell profiling of exosome secretion (2019) (0)
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