Susan Lindquist

Q: What Schools Are Affiliated With Susan Lindquist

Susan Lindquist is affiliated with the following schools: University of Missouri–Kansas City, Vanderbilt University, Massachusetts Institute of Technology, University of Chicago, University of Illinois Urbana-Champaign, University of Washington, University of Bonn, University of Pennsylvania, Harvard University

Susan Lindquist's AcademicInfluence.com Rankings

Susan Lindquist

Biology

#387

World Rank

#697

Historical Rank

#230

USA Rank

Molecular Biology

#74

World Rank

#76

Historical Rank

#49

USA Rank

Genetics

#62

World Rank

#94

Historical Rank

#41

USA Rank

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Biology

Why Is Susan Lindquist Influential?

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According to Wikipedia, Susan Lee Lindquist, ForMemRS was an American professor of biology at MIT specializing in molecular biology, particularly the protein folding problem within a family of molecules known as heat-shock proteins, and prions. Lindquist was a member and former director of the Whitehead Institute and was awarded the National Medal of Science in 2010.

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Susan Lindquist's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The heat-shock proteins. (1988) (3631)
The heat-shock response. (1986) (3412)
HSP90 and the chaperoning of cancer (2005) (2341)
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. (1993) (2257)
Hsp90 as a capacitor for morphological evolution (1998) (2184)
HSP90 at the hub of protein homeostasis: emerging mechanistic insights (2010) (1632)
Hsp104, Hsp70, and Hsp40 A Novel Chaperone System that Rescues Previously Aggregated Proteins (1998) (1349)
Hsp90 as a capacitor of phenotypic variation (2002) (1326)
α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models (2006) (1278)
Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]. (1995) (1022)
Nucleated conformational conversion and the replication of conformational information by a prion determinant. (2000) (948)
The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome (1989) (917)
Protein disaggregation mediated by heat-shock protein Hspl04 (1994) (887)
A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins (2009) (885)
HSP104 required for induced thermotolerance. (1990) (816)
Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis (2007) (800)
Reduced levels of hsp90 compromise steroid receptor action in vivo (1990) (780)
Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology (2003) (780)
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition (2012) (722)
A yeast prion provides a mechanism for genetic variation and phenotypic diversity (2000) (681)
hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures (1989) (677)
Heat Shock Protein 101 Plays a Crucial Role in Thermotolerance in Arabidopsis (2000) (676)
Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (675)
Multiple effects of trehalose on protein folding in vitro and in vivo. (1998) (659)
Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition (2003) (632)
HSP100/Clp proteins: a common mechanism explains diverse functions. (1996) (622)
HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers (2012) (616)
Support for the Prion Hypothesis for Inheritance of a Phenotypic Trait in Yeast (1996) (615)
Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi (2005) (612)
Heat Shock (1991) (606)
Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI +], a Heritable Prion-like Factor of S. cerevisiae (1997) (582)
Hsp104 is required for tolerance to many forms of stress. (1992) (574)
A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties (2003) (553)
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. (2000) (537)
Prions as adaptive conduits of memory and inheritance (2005) (527)
Rnq1: an epigenetic modifier of protein function in yeast. (2000) (506)
Neurotoxicity and Neurodegeneration When PrP Accumulates in the Cytosol (2002) (496)
RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis (1986) (488)
The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels (1982) (482)
Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose. (1998) (479)
Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers (2004) (475)
α-Synuclein: membrane interactions and toxicity in Parkinson's disease. (2010) (466)
Structural insights into a yeast prion illuminate nucleation and strain diversity (2005) (462)
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis (2008) (450)
α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity (2009) (448)
A suite of Gateway® cloning vectors for high‐throughput genetic analysis in Saccharomyces cerevisiae (2007) (442)
Increase in Activity During Calorie Restriction Requires Sirt1 (2005) (438)
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders (2015) (431)
Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase (1995) (421)
Heat-shock protein hsp90 governs the activity of pp60v-src kinase. (1993) (414)
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons (2013) (410)
The consequences of expressing hsp70 in Drosophila cells at normal temperatures. (1992) (403)
Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein (2003) (402)
Regulation of protein synthesis during heat shock (1981) (401)
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. (2000) (394)
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity (2008) (393)
hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery (1984) (387)
Prions are a common mechanism for phenotypic inheritance in wild yeasts (2012) (383)
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone. (1997) (378)
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. (2006) (364)
Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast (2011) (358)
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease (2009) (356)
A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways (2014) (345)
Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits (2004) (342)
Varying patterns of protein synthesis in Drosophila during heat shock: implications for regulation. (1980) (329)
Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation (2010) (319)
Conversion of PrP to a Self-Perpetuating PrPSc-like Conformation in the Cytosol (2002) (317)
PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition (2014) (315)
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. (2008) (314)
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish (2013) (313)
Widespread regulation of translation by elongation pausing in heat shock (2013) (303)
Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation (2001) (301)
Flanking sequences profoundly alter polyglutamine toxicity in yeast. (2006) (294)
The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy (2014) (293)
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures (2007) (293)
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. (2008) (291)
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity (2009) (290)
18 Heat Shock Proteins and Stress Tolerance (1994) (282)
An ancient developmental induction: heat-shock proteins induced in sporulation and oogenesis. (1986) (277)
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer (2011) (276)
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. (2006) (275)
Transgenerational epigenetic inheritance: how important is it? (2013) (268)
Hspl04 is a highly conserved protein with two essential nucleotide-binding sites (1991) (267)
Prion Switching in Response to Environmental Stress (2008) (259)
Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition (2013) (257)
Mechanisms of protein-folding diseases at a glance (2014) (253)
Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance (2004) (250)
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal (2006) (246)
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. (2003) (246)
Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways. (1995) (245)
A Chaperone Pathway in Protein Disaggregation (2005) (245)
Antagonistic Interactions between Yeast Chaperones Hsp104 and Hsp70 in Prion Curing (1999) (245)
The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader (1985) (243)
Chaperone-supervised conversion of prion protein to its protease-resistant form. (1997) (243)
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State (2013) (243)
Prions as protein-based genetic elements. (2002) (241)
A Cyclophilin Function in Hsp90-Dependent Signal Transduction (1996) (235)
Hsp26 is not required for growth at high temperatures, nor for thermotolerance, spore development, or germination (1986) (233)
Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons (2013) (230)
The cellular prion protein mediates neurotoxic signalling of β‐sheet‐rich conformers independent of prion replication (2011) (229)
Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. (1996) (228)
In vivo analysis of the Hsp90 cochaperone Sti1 (p60) (1997) (225)
Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. (1996) (225)
Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. (2004) (223)
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? (2010) (223)
Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B (2013) (218)
Cdc37 is a molecular chaperone with specific functions in signal transduction. (1997) (215)
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. (2006) (215)
The role of heat-shock proteins in thermotolerance. (1993) (212)
Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits (2010) (210)
Hyperthermia protects mice against the lethal effects of endotoxin. (1993) (210)
The role of Sis1 in the maintenance of the [RNQ+] prion (2001) (198)
Oligopeptide-repeat expansions modulate ‘protein-only’ inheritance in yeast (1999) (195)
A Yeast Model of FUS/TLS-Dependent Cytotoxicity (2011) (195)
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90. (1999) (192)
SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones (2012) (189)
Heat shock and recovery are mediated by different translational mechanisms. (1982) (189)
Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes. (1994) (188)
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits (2008) (188)
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. (2004) (185)
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions (2008) (185)
Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor‐1 mutants (2002) (185)
Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis (2008) (184)
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models (2010) (180)
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. (2010) (179)
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. (2008) (179)
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. (2004) (177)
An Arabidopsis heat shock protein complements a thermotolerance defect in yeast. (1994) (176)
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases (2007) (175)
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. (2011) (173)
Inactivation of the ampD gene causes semiconstitutive overproduction of the inducible Citrobacter freundii beta-lactamase (1987) (172)
Is the major Drosophila heat shock protein present in cells that have not been heat shocked? (1983) (168)
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity (2007) (165)
Chaperone-dependent amyloid assembly protects cells from prion toxicity (2008) (165)
Creating a protein-based element of inheritance. (2000) (163)
A heritable switch in carbon source utilization driven by an unusual yeast prion. (2009) (162)
A new method for manipulating transgenes: engineering heat tolerance in a complex, multicellular organism (1993) (162)
Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion (2013) (161)
Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae. (1994) (161)
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. (2011) (159)
Prions, protein homeostasis, and phenotypic diversity. (2010) (158)
Mitochondrial metabolism promotes adaptation to proteotoxic stress (2019) (158)
Phenotypic Diversity and Altered Environmental Plasticity in Arabidopsis thaliana with Reduced Hsp90 Levels (2007) (157)
Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock. (2014) (156)
A network of protein interactions determines polyglutamine toxicity. (2006) (154)
Mad Cows Meet Psi-chotic Yeast: The Expansion of the Prion Hypothesis (1997) (154)
Intracellular localization of heat shock proteins in Drosophila (1980) (151)
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits (2016) (150)
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. (2018) (150)
Genetic Architecture of Hsp90-Dependent Drug Resistance (2006) (149)
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+] (2002) (147)
Binding of the Citrobacter freundii AmpR regulator to a single DNA site provides both autoregulation and activation of the inducible ampC beta-lactamase gene (1989) (146)
Changes in hsp70 alter thermotolerance and heat-shock regulation in Drosophila. (1991) (145)
RNA metabolism: strategies for regulation in the heat shock response. (1990) (144)
Prion recognition elements govern nucleation, strain specificity and species barriers (2007) (141)
Blessings in disguise: biological benefits of prion-like mechanisms. (2013) (139)
Amyloid deposits: Protection against toxic protein species? (2009) (139)
Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae (1991) (136)
Inhibiting the transcription factor HSF1 as an anticancer strategy (2009) (136)
Cross-Kingdom Chemical Communication Drives a Heritable, Mutually Beneficial Prion-Based Transformation of Metabolism (2014) (135)
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity (2014) (135)
Using the heat-shock response to discover anticancer compounds that target protein homeostasis. (2011) (134)
Genetic evidence for a functional relationship between Hsp104 and Hsp70 (1993) (133)
Strains of [PSI+] are distinguished by their efficiencies of prion‐mediated conformational conversion (2001) (132)
Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104 (2007) (132)
HSP90-buffered genetic variation is common in Arabidopsis thaliana (2008) (130)
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells (2014) (130)
Spontaneous Generation of Prion Infectivity in Fatal Familial Insomnia Knockin Mice (2009) (129)
Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis. (1999) (129)
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. (2012) (128)
The ATPase Activity of Hsp104, Effects of Environmental Conditions and Mutations* (1998) (128)
Luminidependens (LD) is an Arabidopsis protein with prion behavior (2016) (127)
Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein. (2002) (127)
Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers (2012) (121)
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation (2010) (119)
Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation (1995) (118)
Conserved features of intermediates in amyloid assembly determine their benign or toxic states (2012) (116)
Chaperones as thermodynamic sensors of drug–target interactions reveal kinase inhibitor specificities in living cells (2013) (116)
The yeast non‐Mendelian factor [ETA+] is a variant of [PSI+], a prion‐like form of release factor eRF3 (1999) (116)
Polyamine pathway contributes to the pathogenesis of Parkinson disease (2010) (115)
De novo generation of a PrPSc-like conformation in living cells (1999) (115)
Regulation of HSP70 synthesis by messenger RNA degradation. (1989) (115)
The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock. (1988) (114)
Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region. (2004) (111)
FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes. (1997) (110)
Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus (2015) (110)
Inhibiting the transcription factor HSF1 as an anticancer strategy. (2009) (108)
The elongation of yeast prion fibers involves separable steps of association and conversion. (2004) (108)
Motor Mechanism for Protein Threading through Hsp104 (2009) (107)
AmpG, a signal transducer in chromosomal β‐lactamase induction (1993) (107)
Translational efficiency of heat-induced messages in Drosophila melanogaster cells. (1980) (107)
Analysis of prion factors in yeast. (2002) (107)
[PSI+]: an epigenetic modulator of translation termination efficiency. (1999) (107)
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. (2017) (104)
Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease (2009) (103)
HSP90 Shapes the Consequences of Human Genetic Variation (2017) (103)
Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation. (1999) (102)
hsp26 of Saccharomyces cerevisiae is related to the superfamily of small heat shock proteins but is without a demonstrable function (1989) (100)
The role of conformational flexibility in prion propagation and maintenance for Sup35p (2001) (100)
The Prion Protein Knockout Mouse (2007) (99)
Translation of unspliced transcripts after heat shock. (1988) (99)
HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models (2014) (96)
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes (2002) (94)
Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP. (1997) (92)
Rapid Selection of Cyclic Peptides that Reduce α-Synuclein Toxicity in Yeast and Animal Models (2009) (92)
Prion protein gene polymorphisms in Saccharomyces cerevisiae (2003) (92)
Calcineurin determines toxic versus beneficial responses to α-synuclein (2014) (91)
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+] (2009) (89)
Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB) (2011) (87)
An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists (2014) (87)
Selective translation and degradation of heat-shock messenger RNAs in Drosophila. (1990) (86)
BETASCAN: Probable β-amyloids Identified by Pairwise Probabilistic Analysis (2009) (86)
Protein folding sculpting evolutionary change. (2009) (85)
Inhibition of heat shock protein synthesis by heat-inducible antisense RNA. (1986) (84)
Heat-shock proteins and stress tolerance in microorganisms (1992) (82)
Changing patterns of gene expression during sporulation in yeast. (1984) (82)
ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data (2011) (82)
Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. (2012) (81)
Protein-only inheritance in yeast: something to get [PSI+]-ched about. (2000) (81)
Yeast prion [psi +] and its determinant, Sup35p. (1999) (81)
Characterization of an HSP70 Cognate Gene Family in Arabidopsis. (1988) (81)
Bidirectional amyloid fiber growth for a yeast prion determinant (2001) (80)
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration (2008) (77)
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. (2017) (77)
Subunit interactions influence the biochemical and biological properties of Hsp104. (2001) (76)
Autoregulation of the Heat-Shock Response (1993) (76)
Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities (2008) (76)
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes. (1987) (75)
A chaperone pathway in protein disaggregation: Hsp26 ALTERS THE NATURE OF PROTEIN AGGREGATES TO FACILITATE REACTIVATION BY Hsp104. VOLUME 280 (2005) PAGES 23869-23875 (2006) (73)
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia (2021) (72)
Prion formation by a yeast GLFG nucleoporin (2012) (72)
Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics. (2014) (71)
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms* (2011) (71)
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease (2008) (71)
The intracellular location of yeast heat-shock protein 26 varies with metabolism (1989) (71)
Maintenance and inheritance of yeast prions. (1996) (70)
Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (70)
Heat-shock proteins and stress tolerance in microorganisms. (1992) (69)
Non-toxic antimicrobials that evade drug resistance (2015) (69)
Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. (2010) (69)
Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding (2002) (69)
Harnessing Natural Diversity to Probe Metabolic Pathways (2005) (66)
Toward stem cell-based phenotypic screens for neurodegenerative diseases (2015) (65)
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs (2015) (65)
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome (2015) (63)
Loss of native &agr;-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells (2017) (61)
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs (2008) (61)
A method for probing the mutational landscape of amyloid structure (2011) (60)
Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. (2008) (60)
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. (2011) (60)
Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register (2017) (59)
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus (2019) (59)
Structure-activity relationships for withanolides as inducers of the cellular heat-shock response. (2014) (58)
Optical trapping with high forces reveals unexpected behaviors of prion fibrils (2010) (57)
Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes (2011) (56)
Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster (1994) (56)
Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis (2014) (56)
HSF1 phase transition mediates stress adaptation and cell fate decisions (2019) (55)
Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae. (2001) (55)
Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon. (1991) (54)
Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1 (2014) (54)
Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response. (1998) (53)
Transcriptional derepression of the Saccharomyces cerevisiae HSP26 gene during heat shock (1990) (51)
The Peptidyl-prolyl Isomerase Domain of the CyP-40 Cyclophilin Homolog Cpr7 Is Not Required to Support Growth or Glucocorticoid Receptor Activity in Saccharomyces cerevisiae* (1998) (51)
The role of Hsp104 in stress tolerance and [PSI+] propagation in Saccharomyces cerevisiae. (1995) (50)
Conversion of a yeast prion protein to an infectious form in bacteria (2010) (50)
Sequences of wild-type and mutant ampD genes of Citrobacter freundii and Enterobacter cloacae (1993) (50)
AmpG, a signal transducer in chromosomal beta-lactamase induction. (1993) (48)
An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component (2012) (47)
Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models (2009) (46)
Prion Pathogenesis is Independent of Caspase-12 (2007) (46)
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers (2016) (44)
A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance (2017) (43)
Combating neurodegenerative disease with chemical probes and model systems. (2014) (43)
An inter‐species protein–protein interaction network across vast evolutionary distance (2016) (42)
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity (2018) (41)
Genetic basis of induction and overproduction of chromosomal class I beta-lactamase in nonfastidious gram-negative bacilli. (1988) (41)
Investigating protein conformation-based inheritance and disease in yeast. (2001) (41)
Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases (2013) (41)
Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures (2012) (40)
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity (2002) (40)
BETASCAN: Probable beta-amyloids Identified by Pairwise Probabilistic Analysis (2009) (39)
Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35–NM (2007) (38)
Hsp90 and Chromatin: Where is the Link? (2003) (34)
Context dependent neuroprotective properties of prion protein (PrP) (2009) (33)
Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect against Infectious Prion Toxicity In Vivo (2007) (33)
Interleukin-1 beta increases the biosynthesis of the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat pancreatic islets. (1991) (32)
Probing the Role of PrP Repeats in Conformational Conversion and Amyloid Assembly of Chimeric Yeast Prions* (2007) (32)
From yeast to patient neurons and back again: Powerful new discovery platforms (2014) (31)
Evidence that alpha-synuclein does not inhibit phospholipase D. (2009) (31)
Navigating the ClpB channel to solution (2005) (31)
The basis for a heat-induced developmental defect: defining crucial lesions. (1995) (30)
16 Posttranscriptional Regulation of Heat Shock Protein Synthesis in Drosophila (1990) (30)
Chromosomal beta-lactam resistance in enterobacteria. (1986) (30)
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4. (2020) (30)
A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. (2016) (30)
Subcellular differentiation in sporulating yeast cells (1986) (30)
Interactions among α-synuclein, dopamine, and biomembranes (2007) (29)
Self-perpetuating epigenetic pili switches in bacteria (2002) (29)
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation (2019) (28)
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity (2002) (27)
Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors. (2015) (27)
Heat shock--a comparison of Drosophila and yeast. (1984) (26)
Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease. (2012) (26)
FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome (2017) (24)
Physical properties of polymorphic yeast prion amyloid fibers. (2011) (24)
Rnq 1 : An Epigenetic Modifier of Protein (2000) (24)
Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy (2017) (24)
Hsp90 as a capacitor of phenotypic (2002) (23)
A possible epigenetic mechanism for the persistence of memory. (2004) (23)
Expression of a Drosophila heat shock protein in mammalian cells: transient association with nucleoli after heat shock. (1984) (23)
STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions (2011) (23)
The Schizosaccharomyces pombe Hsp104 Disaggregase Is Unable to Propagate the [PSI +] Prion (2009) (22)
4 – Coordinate and Noncoordinate Gene Expression during Heat Shock: A Model for Regulation (1985) (21)
Hsp90 and chromatin (2003) (21)
[PSI+], SUP35, and chaperones. (2001) (21)
Signalling proteins in enterobacterial AmpC beta-lactamase regulation. (1989) (21)
The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability (2022) (21)
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. (2012) (20)
Purification and properties of Hsp104 from yeast. (1998) (20)
Contribution of N‐ and C‐terminal domains to the function of Hsp90 in Saccharomyces cerevisiae (1999) (19)
Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered. (1987) (18)
Detection of compounds that rescue Rab1-synuclein toxicity. (2008) (18)
Aggregation and Fibril Structure of AβM01-42 and Aβ1-42. (2017) (18)
The yeast prion [PSI+]: molecular insights and functional consequences. (2001) (18)
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. (2011) (17)
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast (2002) (16)
Chapter 23 Mechanisms of chromosomal β-lactamase induction in Gram-negative bacteria (1994) (16)
Induction of chromosomal β-lactamase expression in enterobacteria (1986) (15)
Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani (2001) (15)
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans (2013) (15)
Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein (2009) (14)
Translational Regulation in the Heat-Shock Response of Drosophila Cells (1987) (14)
Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. (2017) (14)
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis. (2018) (14)
RNA-directed DNA methylation in Arabidopsis (2002) (13)
Hsp101 plays a crucial role in thermotolerance in Arabidopsis. (2000) (13)
Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity (2014) (13)
A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin (2009) (13)
Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast (2017) (12)
Scarless Gene Tagging with One-Step Transformation and Two-Step Selection in Saccharomyces cerevisiae and Schizosaccharomyces pombe (2016) (12)
This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected on April 29 , 1997 . In vivo functions of the Saccharomyces cerevisiae Hsp 90 chaperone (1997) (12)
Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity (2014) (11)
Induction and maintenance of nonsymmetrical DNA methylation in Neurospora (2002) (11)
Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein (2002) (11)
Mad cows meet mad yeast: the prion hypothesis. (1996) (11)
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML (2021) (10)
TorsinA and the TorsinA-Interacting Protein Printor Have No Impact on Endoplasmic Reticulum Stress or Protein Trafficking in Yeast (2011) (10)
Self-perpetuating structural states in biology, disease, and genetics (2002) (10)
Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway (2018) (9)
Amyloid fibres of Sup35 support a prion-like mechanism of inheritance in yeast. (1998) (9)
Loss of Hsp 70 Exacerbates Pathogenesis but not Levels of Fibrillar Aggregates in a Mouse Model of Huntington ’ s Disease (2010) (8)
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state (2022) (8)
Self-perpetuating changes in Sup35 protein conformation as a mechanism of heredity in yeast. (2001) (8)
mouse models of Huntington ' s and prion diseases The power of automated high-resolution behavior analysis revealed by its application to (2007) (8)
Differential mRNA Stability: A Regulatory Strategy for Hsp70 Synthesis (1990) (7)
. . . but yeast prion offers clues about evolution (2000) (7)
De novo generation of a PrP Sc -like (1999) (7)
Illuminating aggregate heterogeneity in neurodegenerative disease (2007) (7)
Heritable chromatin structure: Mapping “memory” in histones H3 and H4 (2002) (7)
THE ROLE OF HSP104 IN STRESS TOLERANCE AND PRION MAINTENANCE (1999) (6)
Heat-Shock Protein hsp90 Governs the Activity of pp60 (2007) (6)
The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target for Drug Development (2015) (5)
Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity (2009) (5)
Prion formation by a yeast (2012) (5)
Response from Chernoff et al. (1995) (5)
Santagata Supports the Anabolic Malignant State Tight Coordination of Protein Translation and HSF 1 Activation (2014) (5)
Evidence that α -Synuclein Does Not Inhibit Phospholipase D † (2009) (5)
Interactions among prions and prion “strains” in yeast (2002) (5)
A Phenotype Under Challenge (2007) (4)
Induction of chromosomal beta-lactamase expression in enterobacteria. (1986) (4)
Prion Switching in Response to Environmental (2008) (4)
Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress (2019) (4)
Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3 (2011) (4)
Curing Chaperones Hsp 104 and Hsp 70 in Prion Antagonistic Interactions between Yeast (1999) (4)
Nicolas Rohner for Loss of Eyes in Cavefish Cryptic Variation in Morphological Evolution : HSP 90 as a Capacitor (2014) (3)
Green tea ( 2 )-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington’s disease models (2006) (3)
Corrigendum: Combating neurodegenerative disease with chemical probes and model systems (2015) (3)
Genetic Analysis of Heat Shock Protein Functions in Yeast (1991) (3)
Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding Diseases (2008) (3)
$^{13}C$ NMR Studies of Metabolic Pathways Regulated by HSP104 in Saccharomyces cerevisiae (1998) (2)
Stress-induced proteins : proceedings of a Hoffmann-La Roche-director's sponsors UCLA symposia, held at Keystone, Colorado, April 10-16, 1988 (1989) (2)
Won't you change partners and dance? (1992) (2)
Using yeast to understand protein folding diseases: an interview with Susan Lindquist by Kristin Kain. (2008) (2)
Profoundly different prion diseases in knockin mice carrying single PrP codon substitutions associated with human diseases Citation (2013) (2)
Interview: Protein folding and studies of neurodegenerative diseases. (2008) (2)
Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity (2014) (2)
HeatShockProteins Affect RNA Processing during theHeatShock Response ofSaccharomyces cerevisiae (1991) (1)
Cooper in Parkinson ' s Models-Synuclein Blocks ER-Golgi Traffic and Rab 1 Rescues Neuron Loss (2013) (1)
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus (2019) (1)
Author-Initiated Retraction: Donmez et al., SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones (2016) (1)
Lindquist Protein Folding Sculpting Evolutionary Change (2010) (1)
Preferential Deadenylation of Hsp7O mRNA Plays a Key Role in Regulating Hsp7O Expression in Drosophila melanogaster (1)
A cytoplasmically inherited prionlike genetic element in yeast. (1996) (1)
White How Detection of Compounds That Rescue Rab 1-Synuclein Toxicity (2008) (1)
Proteasomal complex regulation by heat‐shock proteins in cancer (2013) (1)
Abstract P6-15-06: Heat Shock Protein 90 Inhibition Limits the Emergence of Tamoxifen Resistance (2010) (1)
Self-Perpetuating Changes in Sup35 Protein Conformation as A mechanism of Heredity in Yeast (2000) (1)
Erratum: Transgenerational epigenetic inheritance: how important is it? (2013) (1)
Susan Lee Lindquist (1949–2016) (2016) (1)
Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition. (2020) (1)
Three Quite Different Things That Matter to Me (2010) (1)
The insulation of genes from external enhancers and silencing chromatin (2002) (1)
Disrupting fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles (2013) (1)
and Prognosis Progress − Ameliorate Protein Misfolding and Aggregation Diseases Chemical and Biological Approaches for Adapting Proteostasis to service (2011) (1)
Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition. (2020) (1)
Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach (2015) (1)
Figure 62, Spectroscopic data for SID 99376533 (2012) (0)
PARTICIPATION OF STRESS PROTEINS IN EXOGENOUS LUCIFERASE EXPRESSION IN YEAST (1997) (0)
Table 2, Summary of SAR Performed Upon the 4-chlorobenzamide (2012) (0)
Figure 14, Spectroscopic data for SID 99245537 (2012) (0)
P5-01-13: High Levels of Nuclear Heat Shock Factor 1 (HSF1) Are Associated with Poor Prognosis in Breast Cancer: Results from the Nurses' Health Study. (2011) (0)
Analysis of the AAA sensor-2 ATPase domain of Hsp104 wi fluorescent probe of nucleoti (2016) (0)
Table 3, Physical Properties of 4-chlorobenzamide Derivatives (2012) (0)
Arthur M. Sackler, M.D. (2002) (0)
Figure 27, Spectroscopic data for SID 99245535 (2012) (0)
Yeun Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue (2016) (0)
Methods for building genomic networks and uses thereof (2018) (0)
Transient Hsp90 suppression promotes a heritable change in protein translation (2018) (0)
A method for detecting in yeast for influence by means of protein folding (2002) (0)
Alzheimer ' s Disease Risk Factors in Yeast Toxicity , Endocytic Trafficking , and β Functional Links Between A (2013) (0)
Figure 20, Spectroscopic data for SID 99376501 (2012) (0)
The Stress Response and Stress Proteins (2020) (0)
Scheme 1, Synthesis of the Probe (ML212) (2013) (0)
Environmentally Acquired Traits Epigenetics in the Extreme: Prions and the Inheritance of (2013) (0)
Table 10, Heteroaromatic Substitution of the 7-chloroquinoline (2012) (0)
Table 2, Summary of Probe Properties Computed from Structure ML316 (2014) (0)
Mad Cows Meet Psi-chotic Yeast : Minireview The Expansion of the Prion Hypothesis (1997) (0)
Figure 40, Spectroscopic data for SID 99376517 (2012) (0)
Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue of (2014) (0)
Figure 53, Spectroscopic data for SID 99376524 (2012) (0)
Preferential Deadenylation ofHsp7OmRNA Plays a KeyRole inRegulating Hsp7OExpression inDrosophila melanogaster (1994) (0)
Abstracts of papers presented at the 1994 Meeting on Biology of Heat Shock Proteins & Molecular Chaperones, May 4-May 8, 1994 (1994) (0)
Physical Properties of Yeast Prion Proteins Studied with Optical Tweezers (2010) (0)
Prion Proteins: Surprising Genetics, Surprising Biology and Surprising Folds (2008) (0)
Figure 32, Spectroscopic data for SID 99376523 (2012) (0)
Figure 41, Spectroscopic data for SID 99376498 (2012) (0)
Abstracts of papers presented at the 1998 Meeting on Molecular Chaperones and the Heat Shock Response, May 6-May 10, 1998 (1996) (0)
Aggregation Diseases ndProteostasis to Ameliorate Protein Misfolding a Chemical and Biological Approaches for Adapting (2011) (0)
Table 5, Physical Properties of Additional Amides and Amide Bond Surrogates (2012) (0)
Figure 28, Spectroscopic data for SID 99376509 (2012) (0)
Probing Metabolic Requirements for Fungal Virulence — Probe 1 (2014) (0)
Figure 58, Spectroscopic data for SID 99376545 (2012) (0)
Figure 15, Spectroscopic data for SID 99245531 (2012) (0)
HSF1 phase transition mediates stress adaptation and cell fate decisions (2020) (0)
Figure 55, Spectroscopic data for SID 99376554 (2012) (0)
Figure 25, Spectroscopic data for SID 99376504 (2012) (0)
Figure 46, Spectroscopic data for SID 99376513 (2012) (0)
Method of proof in yeast for medium affect the protein folding (2002) (0)
Transmission of prions (2002) (0)
Simple Cellular Solutions to Complex Problems (2009) (0)
Over the years , yeast , fruit fl ies , mustard plants and mice have struggled through their own versions of an extreme reality TV show in the laboratory of Whitehead Member (2005) (0)
QnAs with Susan L. Lindquist. Interviewed by Prashant Nair. (2011) (0)
Abstract A23: Cell autonomous and nonautonomous activities of heat shock factor 1 support tumor initiation, progression, and metastasis (2013) (0)
Figure 36, Spectroscopic data for SID 99245548 (2012) (0)
Figure 22, Spectroscopic data for SID 99245567 (2012) (0)
buffering role of HSP 90 in disease manifestations d HSP 90 chaperoning shapes allele expressivity (2017) (0)
Figure 21, Spectroscopic data for SID 99376507 (2012) (0)
Table 4, Evaluation of Additional Amides and Amide Bond Surrogates (2012) (0)
Figure 61, Spectroscopic data for SID 99376515 (2012) (0)
Table 7, Physical Properties of Piperazine Derivatives (2012) (0)
Figure 51, Spectroscopic data for SID 99245561 (2012) (0)
Figure 10, Evaluating Loss of C. glabrata Mitochondrial Membrane Potential with JC-1 (2014) (0)
Figure 10, Critical Path (2012) (0)
WP: Workshop Lectures (2010) (0)
] Prion (0)
Abstract C132: Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia. (2013) (0)
Chaperoning brain degeneration (2002) (0)
Figure 34, Spectroscopic data for SID 99245539 (2012) (0)
Figure 31, Spectroscopic data for SID 99245553 (2012) (0)
In Situ Peroxidase Labelin g and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons Graphical (2017) (0)
Figure 54, Spectroscopic data for SID 99376503 (2012) (0)
Mad cows and psi-chotic yeast: an extension of the prion hypothesis (1999) (0)
Accelerating Yeast Prion Biology using Droplet Microfluidics (2012) (0)
Figure 13, Best-in-class Chemosensitizers for Reversing Fluconazole Resistance (MIC=1.2–2.8 μM) (2012) (0)
Figure 44, Spectroscopic data for SID 99376526 (2012) (0)
Table 9, Physical Properties of Substituted Quinoline Analogs (2012) (0)
Figure 50, Spectroscopic data for SID 99376557 (2012) (0)
Table 1, Plasma Stability of Probe ML316 and analogs CID3889161 and CID56604835 (2014) (0)
Figure 42, Spectroscopic data for SID 99376530 (2012) (0)
Naturally occurring fibrillar proteins can induce AA amyloidosis by a prion-like mechanism (2012) (0)
Figure 37, Spectroscopic data for SID 99376512 (2012) (0)
13 Stress Tolerance, Metabolism, and Development: The Many Flavors of Trehalose (2005) (0)
Figure 39, Spectroscopic data for SID 99376508 (2012) (0)
National Academy of Sciences Sackler Colloquia Series (2002) (0)
Figure 33, Spectroscopic data for SID 99245557 (2012) (0)
Figure 52, Spectroscopic data for SID 99245569 (2012) (0)
P3-01-09: Oncogenic Activation of HSF1 Enables the Malignant Progression of Breast Carcinoma. (2011) (0)
Tight Coordination of Protein Translation and Heat Shock Factor 1 Activation Supports the Anabolic Malignant State (2013) (0)
Abstract A28: Targeting the epigenetic state regulating cancer cell vulnerability to proteasome inhibition (2017) (0)
Figure 24, Spectroscopic data for SID 99376500 (2012) (0)
Excited About Science (2003) (0)
Modelling neurodegeneration in S . cerevisiae : Why cook with Baker ’ s yeast ? (2012) (0)
Figure 60, Spectroscopic data for SID 99245570 (2012) (0)
Binding oftheCitrobacter freundii AmpRRegulator toaSingle DNA Site Provides BothAutoregulation andActivation ofthe Inducible ampCr-Lactamase Gene (1989) (0)
Protein folding shapes the adaptive value of genetic variation (2011) (0)
Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress (2018) (0)
Probing Structure and Mechanics of Yeast Prion Proteins with Optical Tweezers (2009) (0)
Mammalian-Membrane-Two-Hybrid ( MaMTH ) : a novel split-ubiquitin assay for investigation of signaling pathways in human cells (2014) (0)
Figure 43, Spectroscopic data for SID 99376518 (2012) (0)
Figure 18, Spectroscopic data for SID 99376522 (2012) (0)
Heat-shock protein 104 expression is sufficient for thermotolerance in yeast ( chaperones / stress tolerance / heat-shock factor / prion ) (0)
Figure 23, Spectroscopic data for SID 99376531 (2012) (0)
Figure 16, Spectroscopic data for SID 99376520 (2012) (0)
Table 1, Summary of Assays Completed (2012) (0)
Figure 59, Spectroscopic data for SID 99376552 (2012) (0)
Yeast Cells as a Discovery Platform for Neurodegenerative Disease (2005) (0)
Figure 48, Spectroscopic data for SID 99376502 (2012) (0)
Table 8, Summary of SAR Performed with Substituted Quinolines (2012) (0)
Figure 38, Spectroscopic data for SID 99376525 (2012) (0)
Figure 30, Spectroscopic data for SID 99376511 (2012) (0)
Fungal Prions and Evolutionary Trajectories (2016) (0)
Observation of Amyloid-Like Fibers of the Sup35 Protein from Saccharomyces Cerevisiae (2000) (0)
Abstract OT3-2-05: Randomized phase II study of fulvestrant with or without ganetespib in patients (pts) with hormone receptor (HR)-positive metastatic breast cancer (2013) (0)
Prions, From Structure to Epigenetics and Neuronal Functions (2012) (0)
Figure 5, ML316 Selectively Inhibits Growth of C. albicans (A and B) over 3T3 Fibroblasts (C) (2014) (0)
Peptide microarray-based mapping of prion transmission barriers (2005) (0)
Figure 49, Spectroscopic data for SID 99376538 (2012) (0)
A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier. (2011) (0)
Unraveling Molecular Mechanisms and Structures of Self-Perpetuating Prions (2010) (0)
Figure 4, Probe Stability in PBS solution at 23 °C (2012) (0)
Aggregation of Trp>Glu Mutants of the Human Gamma-D Crystallin: A Model for Hereditary or UV-Induced Cataract (2013) (0)
New Mechanisms of Inheritance Based on Self-perpetuating Changes in Protein Conformation (2000) (0)
Metal nanowires from self-assembled protein fibers (2002) (0)
Figure 56, Spectroscopic data for SID 99376537 (2012) (0)
Figure 26, Spectroscopic data for SID 99376527 (2012) (0)
Figure 17, Spectroscopic data for SID 99376521 (2012) (0)
yeast prion A heritable switch in carbon source utilization driven by an unusual (2013) (0)
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay (2002) (0)
Abstract PR07: Mechanisms of stromal reprogramming mediated by heat shock factor 1 (2016) (0)
Table 11, Physical Properties of the Heteroaromatic Surrogates (2012) (0)
Figure 19, Spectroscopic data for SID 99376499 (2012) (0)
Expanding the prion model for the yeast [PSI+] element: Response (2000) (0)
Figure 57, Spectroscopic data for SID 99376553 (2012) (0)
Table 3, SAR Analysis of Ethyl Carbamate (2014) (0)
Table 6, Biological Assay of Piperazine Derivatives (2012) (0)
Sequences ofWild-Type andMutantampDGenesof Citrobacterfreundii andEnterobacter cloacae (1993) (0)
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases (2002) (0)
Does heterochromatin protein 1 always follow code (2002) (0)
Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions (2022) (0)
Compounds, compositions and method for inhibiting the toxicity of a-synuclein. (2005) (0)
Figure 1, Some known inhibitors of fungal mitochondria oxidative phosphorylation (2014) (0)
Susan L. Lindquist. (2002) (0)
Figure 47, Spectroscopic data for SID 99376519 (2012) (0)
Figure 29, Spectroscopic data for SID 99376510 (2012) (0)
HSP26 Gene during Heat Shock (0)
Figure 35, Spectroscopic data for SID 99245543 (2012) (0)
Figure 45, Spectroscopic data for SID 99245559 (2012) (0)

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