Arnold J. Levine | Academic Influence

Why Is Arnold J. Levine Influential?

According to Wikipedia, Arnold J. Levine , is an American Molecular biologist. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was the first recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53.

Arnold J. Levine's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

The Sequence of the Human Genome (9239)
Surfing the p53 network (6305)
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. (4208)
Stochastic Gene Expression in a Single Cell (3446)
The p53 pathway: positive and negative feedback loops (1800)
Transcriptional control of human p53-regulated genes (1759)
A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans (1278)
The coordinate regulation of the p53 and mTOR pathways in cells. (1119)
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway (653)
The P53 pathway: what questions remain to be explored? (642)
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function (631)
The genetics of the p53 pathway, apoptosis and cancer therapy (609)
The regulation of exosome secretion: a novel function of the p53 protein. (576)
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. (558)
p53 regulates maternal reproduction through LIF (402)
p53 Research: the past thirty years and the next thirty years. (358)
A plausible model for the digital response of p53 to DNA damage. (335)
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. (310)
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. (310)
MDM2 is a central node in the p53 pathway: 12 years and counting. (306)
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect (305)
MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells (278)
Negative regulation of tumor suppressor p53 by microRNA miR-504. (277)
Tumor-Associated Mutant p53 Drives the Warburg Effect (274)
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73* (257)
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (256)
The origins and evolution of the p53 family of genes. (254)
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma (242)
Allele-specific p53 mutant reactivation. (242)
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations (225)
Gene assessment and sample classification for gene expression data using a genetic algorithm/k-nearest neighbor method. (201)
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. (197)
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans (188)
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. (184)
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability (179)
Molecular classification of prostate cancer using curated expression signatures (172)
p53 and NF‐κB: different strategies for responding to stress lead to a functional antagonism (166)
miR-143 regulates hexokinase 2 expression in cancer cells (153)
DNA methylation silences miR-132 in prostate cancer (142)
A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells* (138)
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. (122)
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. (119)
Chronic restraint stress attenuates p53 function and promotes tumorigenesis (113)
The regulation of the endosomal compartment by p53 the tumor suppressor gene (110)
The tumor suppressor p53: Cancer and aging (105)
MDM2 SNP309 accelerates colorectal tumour formation in women (103)
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. (102)
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. (100)
p73 regulates serine biosynthesis in cancer (91)
Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. (90)
TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation (86)
Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6 (81)
p53: A new player in reproduction (81)
p53 tumour suppressor (79)
Detection of functional single-nucleotide polymorphisms that affect apoptosis. (79)
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. (78)
Regulation of female reproduction by p53 and its family members (78)
Haplotype structure and selection of the MDM2 oncogene in humans (74)
p63 regulates glutaminase 2 expression (70)
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene (69)
Differential levels of transcription of p53‐regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis (63)
Proliferation and tissue remodeling in cancer: the hallmarks revisited (59)
Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. (56)
A robust meta‐classification strategy for cancer detection from MS data (56)
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival. (55)
The evolution of thymic lymphomas in p53 knockout mice. (51)
High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately (49)
Lactase Persistence and Lipid Pathway Selection in the Maasai (48)
The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors (46)
Germline Mutations and Polymorphisms in the Origins of Cancers in Women (44)
Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers (37)
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. (36)
Structural Evolution and Dynamics of the p53 Proteins. (34)
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy (30)
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells (26)
Recent Natural Selection Identifies a Genetic Variant in a Regulatory Subunit of Protein Phosphatase 2A that Associates with Altered Cancer Risk and Survival (26)
Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes (25)
Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop (25)
A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence (22)
The regulation of human reproduction by p53 and its pathway (20)
Two well-differentiated pancreatic neuroendocrine tumor mouse models (20)
Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma (17)
A Single Nucleotide Polymorphism in the MDM 2 Gene Disrupts the Oscillation of p 53 and MDM 2 Levels in Cells (16)
P53 mutations in lymphomas: position matters. (15)
PCA and Clustering Reveal Alternate mtDNA Phylogeny of N and M Clades (14)
The First Twenty-Five Years of p53 Research (13)
Insights into immune system development and function from mouse T-cell repertoires (12)
The p53HMM algorithm: using profile hidden markov models to detect p53-responsive genes (12)
A robust meta-classification strategy for cancer diagnosis from gene expression data (11)
Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories. (9)
DTIE, a novel core promoter element that directs start site selection in TATA-less genes (9)
Erratum: The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability (Proceedings of the National Academy of Sciences of the United States of America (September 30, 2003) 100:20 (11547-11552)) (8)
Apoptosis Genes (8)
Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5 (8)
Single-nucleotide polymorphisms in the p53 pathway. (7)
Extra View p 53 A new player in reproduction (6)
Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome (6)
Chapter 3 – Tumor Suppressor Genes (5)
Higher order Boolean networks as models of cell state dynamics. (4)
Altered tumor formation and evolutionary Altered tumor formation and evolutionnary selection of genetic variants in the human MDM4 oncogene (3)
The p53 Network (3)
Spontaneous and inherited TP53 genetic alterations (3)
Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397]. (1)
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 25 (10236-10241) DOI: 10.1073/pnas. 0901298106) (1)
Correction for Deco et al., Key role of coupling, delay, and noise in resting brain fluctuations (1)
Cancer Therapy : Preclinical Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk 4 / Cdk 6 (1)
The G→ C polymorphism of the p53 gene in ovum donors is associated with decreased pregnancy rates in wild type recipients (1)
The G->c polymorphism of the p53 gene is strongly associated with decreased pregnancy rates in fresh IVF patients via an ovarian mechanism (1)
The G→ C polymorphism of the p53 gene impairs pregnancy rates and endometrial LIF production in humans (1)
The p 53 HMM algorithm : using profile hidden markov models to detect p 53-responsive genes (1)
Abstract 267: Preclinical investigation of the HSP90 inhibitor, ganetespib, in combination with FDA-approved cytotoxic agents for their potential anti-tumor effects on human neuroendocrine tumors (0)
The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions (0)
Geometric network analysis provides prognostic information in patients with high grade serous carcinoma of the ovary treated with immune checkpoint inhibitors (0)
Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research (0)
Company Profile: Selventa, Inc. (0)
Experimental test of specific predictions of a model for the oscillatory response of p53 to DNA damage. (0)
O2-02-07 Genetic variants on chromosome 9 are associated with late-onset Alzheimer’s disease, variation in allele-specific gene expression, and differential apoptotic response (0)
Abstract 1538: A mouse model that mimics human MEN1 tumor is effective in preclinical neuroendocrine tumor therapeutics (0)
Attenuation of the Rb pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk 4 / Cdk 6 (0)
GermlineMutations and Polymorphisms in the Origins of Cancers inWomen (0)
Identifying novel p53-target genes and their functional analysis (0)
617: SNP309 in MDM2 Associates to Mutations in TP53 and Aggressive Bladder Cancer (0)
Abstract 681: Prognostic role of Perp in breast cancer (0)
Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence (0)
Regulation of mTOR by the tumor suppressor p53 (0)
BIOLOGY Correction for ‘ ‘ Dissection of the high rate constant for the binding of a ribotoxin to the ribosome (0)
Abstract 1178: Allele specific p53 mutant synthetic lethality (0)
Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models (0)
Correction for Sethna et al., Insights into immune system development and function from mouse T-cell repertoires (0)
Abstract 784: Chronic stress promotes tumorigenesis through attenuation of p53 function . (0)
Correction for Atwal et al., Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene (0)
Abstract 4254: Human neuroendocrine Bon 1 cells as a three-dimensional model for the study of human neuroendocrine tumor therapy (0)
Allelic differences for candidate SNP loci in growth responses to chemotherapeutics of NCI 60 cells either wild-type or mutant for p 53 ( Cont ' d ) (0)
Monographs editor. (0)
Abstract 3185: Complement C5 promotes male bias of pancreatic neuroendocrine tumor metastasis (0)

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