Ashraf Brik
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Ashraf Brikchemistry Degrees
Chemistry
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Polymer Chemistry
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Chemical Engineering
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Chemistry
Ashraf Brik's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemical Engineering Stanford University
- Bachelors Chemical Engineering Stanford University
Why Is Ashraf Brik Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ashraf Brik is a full professor at the Schulich Faculty of Chemistry at the Technion Institute of Technology, Israel. His laboratory specializes in developing synthetic methods for chemical synthesis of proteins with post-translational modifications in quantities that allow for them to be studied thoroughly. Brik's group is developing novel modulators based on small molecules, peptides and peptidomimetics, to influence enzymes and proteins involved in various diseases. With the help of these tools, it is possible to understand how molecules and biological systems affect health.
Ashraf Brik's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Small molecules targeting severe acute respiratory syndrome human coronavirus. (2004) (463)
- HIV-1 protease: mechanism and drug discovery. (2003) (347)
- 1,2,3‐Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV‐1 Protease Inhibitors (2005) (240)
- Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins. (2016) (227)
- A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. (2008) (213)
- Highly efficient and chemoselective peptide ubiquitylation. (2009) (212)
- Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein. (2011) (194)
- Structural basis for histone H2B deubiquitination by the SAGA DUB module (2016) (188)
- RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. (2012) (182)
- Total chemical synthesis of di-ubiquitin chains. (2010) (144)
- The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. (2012) (143)
- Rapid Diversity‐Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors (2003) (126)
- Protein Synthesis Assisted by Native Chemical Ligation at Leucine (2010) (124)
- Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology (2013) (115)
- Chemistry and biology of the ubiquitin signal. (2012) (114)
- Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34. (2013) (108)
- Sugar-assisted glycopeptide ligation. (2006) (107)
- Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. (2011) (105)
- Palladium in the Chemical Synthesis and Modification of Proteins. (2017) (104)
- Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly (2011) (100)
- Sugar-assisted ligation in glycoprotein synthesis. (2007) (100)
- N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester. (2010) (96)
- KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth (2015) (89)
- Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases. (2012) (86)
- HIV‐1 Protease: Mechanism and Drug Discovery (2003) (85)
- Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis. (2016) (85)
- Native chemical ligation at glutamine. (2012) (84)
- The U4/U6 Recycling Factor SART3 Has Histone Chaperone Activity and Associates with USP15 to Regulate H2B Deubiquitination* (2014) (83)
- Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. (2013) (83)
- Nonenzymatic polyubiquitination of expressed proteins. (2014) (81)
- Dehydroalanine-based diubiquitin activity probes. (2014) (81)
- Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins. (2016) (80)
- Highly efficient one-pot ligation and desulfurization (2013) (80)
- Extended sugar-assisted glycopeptide ligations: development, scope, and applications. (2007) (72)
- Convergent versus sequential protein synthesis: the case of ubiquitinated and glycosylated H2B. (2015) (72)
- Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction. (2006) (70)
- Protein synthesis by solid-phase chemical ligation using a safety catch linker. (2000) (67)
- Chemical Synthesis and Expression of the HIV‐1 Rev Protein (2011) (63)
- Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins (2018) (62)
- Expeditious chemical synthesis of ubiquitinated peptides employing orthogonal protection and native chemical ligation. (2011) (61)
- Second-generation sugar-assisted ligation: a method for the synthesis of cysteine-containing glycopeptides. (2007) (60)
- Targeting deubiquitinases enabled by chemical synthesis of proteins. (2012) (58)
- Ubiquitin Signaling: Chemistry Comes to the Rescue. (2017) (56)
- Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis. (2016) (55)
- Metathesis in Peptides and Peptidomimetics (2008) (54)
- Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery. (2006) (53)
- A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors. (2002) (52)
- Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module. (2016) (52)
- Chemical and semisynthetic approaches to study and target deubiquitinases. (2016) (50)
- Peptide ligation via side-chain auxiliary. (2008) (49)
- Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations. (2008) (49)
- Chemical and semisynthesis of posttranslationally modified proteins. (2012) (46)
- Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin. (2016) (46)
- De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains (2019) (42)
- N-methylation of isopeptide bond as a strategy to resist deubiquitinases. (2012) (41)
- Sugar-assisted ligation for the synthesis of glycopeptides. (2007) (39)
- Strategies for the preparation of homogenous glycoproteins. (2006) (38)
- Switch peptide via Staudinger reaction. (2008) (36)
- Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules. (2014) (36)
- Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles (2019) (35)
- Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein. (2014) (35)
- Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00488e Click here for additional data file. (2017) (34)
- Protecting group variations of delta-mercaptolysine useful in chemical ubiquitylation. (2010) (33)
- Total chemical synthesis of histones and their analogs, assisted by native chemical ligation and palladium complexes (2017) (32)
- Extended ubiquitin species are protein-based DUB inhibitors (2014) (32)
- The Journey for the Total Chemical Synthesis of a 53 kDa Protein. (2019) (32)
- Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step. (2016) (32)
- One-pot total chemical synthesis of human α-synuclein. (2013) (31)
- Rapid Discovery of Potent Sulfotransferase Inhibitors by Diversity‐Oriented Reaction in Microplates Followed by in situ Screening (2004) (29)
- Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α-Globin-Modulating Deubiquitinase. (2018) (29)
- Polymerization behavior of a bifunctional ubiquitin monomer as a function of the nucleophile site and folding conditions. (2012) (29)
- Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases. (2015) (28)
- Non-enzymatic synthesis of ubiquitin chains: where chemistry makes a difference. (2013) (28)
- Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ (2005) (27)
- Electrostatic interactions dominate the catalytic contribution of arg39 in 4-oxalocrotonate tautomerase. (2004) (27)
- Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior. (2011) (27)
- Palladium-Assisted Cleavage of Peptides and Proteins Containing a Backbone with Thiazolidine Linkage. (2016) (26)
- The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag (2021) (26)
- Exploring the self-assembly of glycopeptides using a diphenylalanine scaffold. (2011) (25)
- Model System for High-Throughput Screening of Novel Human Immunodeficiency Virus Protease Inhibitors in Escherichia coli (2004) (25)
- Chemical chromatin ubiquitylation. (2018) (23)
- Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. (2013) (23)
- Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine. (2014) (23)
- Enhanced Live‐Cell Delivery of Synthetic Proteins Assisted by Cell‐Penetrating Peptides Fused to DABCYL (2021) (22)
- Palladium-Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-cysteine under Aqueous Conditions. (2019) (21)
- Tetrabutylammonium Fluoride‐Mediated Rapid Alkylation Reaction in Microtiter Plates for the Discovery of Enzyme Inhibitors in Situ (2005) (21)
- Chemical and semisynthesis of modified histones (2016) (21)
- Altered Gag Polyprotein Cleavage Specificity of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Mutant Proteases as Demonstrated in a Cell-Based Expression System (2006) (20)
- Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2† †Electronic supplementary information (ESI) available: All experimental procedures, analytical data for small molecules. See DOI: 10.1039/c6sc02758j Click here f (2016) (19)
- Palladium‐Mediated Cleavage of Proteins with Thiazolidine‐Modified Backbone in Live Cells (2019) (19)
- FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics (2018) (18)
- Side-chain assisted ligation in protein synthesis. (2009) (18)
- Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3. (2017) (17)
- General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins (2021) (17)
- On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins (2020) (16)
- Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases. (2003) (16)
- Chemical and Semisynthetic Approaches to Study and Target Deubiquitinases (2016) (14)
- Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins. (2016) (14)
- Metathesis in Peptides and Peptidomimetics. (2008) (13)
- Accessing posttranslationally modified proteins through thiol positioning (2010) (13)
- STUDIES TOWARDS TOTAL SYNTHESIS OF BORRELIDIN, STEREOSELECTIVE SYNTHESIS OF THE POLYSUBSTITUTED MACROLIDIC PART (1997) (13)
- Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates. (2006) (12)
- Mutants of 4‐Oxalocrotonate Tautomerase Catalyze the Decarboxylation of Oxaloacetate through an Imine Mechanism (2002) (12)
- Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation. (2020) (11)
- Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites. (2018) (11)
- Studies towards total synthesis of borrelidin, regioselective methylation of bis-epoxides and structure determination (1997) (11)
- In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2020) (10)
- Switching Futile para‐Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin‐Specific Protease‐2 Inhibition, Electrocatalysis, and Quantification (2017) (10)
- Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04518b (2018) (10)
- Palladium Mediated Cleavage of Thiazolidine Backbone Modified Proteins in Live Cells. (2019) (9)
- Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions (2020) (9)
- Chemistry and Biology of the Ubiquitin Signal (2012) (9)
- Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy. (2020) (8)
- Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins. (2021) (8)
- ynthesis of SUMO-2-Lys 63-linked diubiquitin hybrid chains assisted by removable solubilizing tags † (2017) (8)
- Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach (2020) (8)
- Signature activities of 20S proteasome include degradation of the ubiquitin-tag with the protein under hypoxia (2019) (8)
- δ‐Mercaptolysine Assisted Ubiquitination (2011) (8)
- Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage. (2019) (8)
- Scope and limitation of side‐chain assisted ligation (2011) (7)
- Chemical and Semisynthesis of Posttranslationally Modified Proteins (2012) (6)
- Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2 (2016) (6)
- Palladium Mediated Cleavage of Thiazolidine Backbone Modified Proteins in Live Cells (2019) (6)
- Dissecting the Roles of the N‐ and C‐Flanking Residues of Acetyllysine Substrates for SIRT1 Activity (2013) (6)
- New Strategies for Glycopeptide, Neoglycopeptide, and Glycoprotein Synthesis (2010) (5)
- Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy (2021) (5)
- Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins. (2021) (4)
- The Development of a Fluorescence‐Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains (2020) (4)
- Highly Efficient Cyclization Approach of Propargylated Peptides via Gold(I)-Mediated Sequential C–N, C–O, and C–C Bond Formation (2021) (4)
- Chemistry and biology of peptides, proteins and beyond. (2013) (4)
- Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities. (2015) (4)
- Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7 (2018) (3)
- Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells (2022) (3)
- Synthesis of N-Hydroxy Isopeptide Containing Proteins. (2015) (3)
- A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC (2021) (3)
- Mirroring Life's Building Blocks. (2019) (2)
- Gold(I)-Mediated Rapid Cyclization of Propargylated Peptides via Imine Formation (2022) (2)
- Palladium‐Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐cysteine under Aqueous Conditions (2019) (2)
- Chemical protein synthesis (2014) (2)
- Sugar-Assisted Ligation for the Synthesis of Glycopeptides (2007) (2)
- Fighting hepatitis C virus with peptide nanotubes. (2011) (1)
- Catalytic Antibodies in Natural Products Synthesis (2005) (1)
- Erratum to RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation [Molecular Cell, 46, (2012), 662-673] (2015) (1)
- Novel chemical tools to facilitate the synthesis and control the folding and Self-assembly of amyloid-forming polypeptides (2011) (1)
- Synthetic Proteins behind the Plasma Barrier: Molecular Spies (2022) (1)
- Synthesis and Evaluation of Ubiquitin–Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity (2021) (1)
- Correction: In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2021) (1)
- Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell‐Penetrating Peptides for Live‐Cell Delivery of Synthetic Proteins (2022) (1)
- Chemical Synthesis of Ubiquitin Chains (2015) (1)
- Microtiter Plate Based Chemistry and in situ Screening: A Useful Approach for Rapid Inhibitor Discovery (2006) (1)
- The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant. (2002) (1)
- Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair (2022) (0)
- Protein Synthesis (2016) (0)
- HIV Protease with inhibitor AB-2 (2005) (0)
- Chemical Synthesis of Ubiquitinated Proteins for Biochemical Studies (2021) (0)
- Probing the cell delivery of synthetic diubiquitin chains (2022) (0)
- Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1 (2022) (0)
- Semi-synthesis of ubiquitinated histone H2B with a native or non-hydrolyzable linkage (2019) (0)
- Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins (2018) (0)
- Cover Picture: Switching Futile para‐Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin‐Specific Protease‐2 Inhibition, Electrocatalysis, and Quantification (ChemBioChem 17/2017) (2017) (0)
- HIV Protease with Scripps AB-3 Inhibitor (2005) (0)
- Spotlights on our sister journals: ChemistryOpen 2/2016 (2016) (0)
- De Novo Synthetic Design for Ultrafast Formation of Disulfide Bonds in Peptides and Proteins .pdf (2020) (0)
- Structure of HIV protease 6X mutant in complex with AB-2. (2007) (0)
- Graphical Abstract: ChemBioChem 9/2002 (2002) (0)
- Guest Editorial: Chemical Protein Synthesis (2011) (0)
- Cover Picture: 1,2,3‐Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV‐1 Protease Inhibitors (ChemBioChem 7/2005) (2005) (0)
- Smart-design of universally decorated nano-particles for drug delivery applications driven by active transport (2022) (0)
- On-Demand Detachment of Maleimide Derivatives on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins (2020) (0)
- Studies Towards Total Synthesis of Borrelidin, Regioselective Methylation of Bis-epoxides and Structure Determination. (2010) (0)
- Proteins through the eyes of an organic chemist (2022) (0)
- Cover Picture: ChemBioChem 9/2002 (2002) (0)
- Extended Sugar-Assisted Ligations: Development, Scope and Applications (2007) (0)
- Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins (2016) (0)
- Semisynthesis and Total Chemical Synthesis of alpha-synuclein to study Post-Translational Modifications in Health and Disease (2011) (0)
- Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06300e (2020) (0)
- Chemical Biology: Powerful Synergy Between Two Cultures (2019) (0)
- FACT and Ubp 10 collaborate to modulate H 2 B deubiquitination and 2 nucleosome dynamics 3 4 (0)
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