David L. Spector | Academic Influence

David L. Spector's AcademicInfluence.com Rankings

David L. Spector

Biology

#5231

World Rank

#7675

Historical Rank

#1760

USA Rank

Cell Biology

#234

World Rank

#243

Historical Rank

#51

USA Rank

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Biology

David L. Spector's Degrees

PhD Cell Biology University of California, Berkeley
Bachelors Biology Stanford University

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Why Is David L. Spector Influential?

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According to Wikipedia, David L. Spector is a cell and molecular biologist best recognized for his research on gene expression and nuclear dynamics. He is currently a professor at Cold Spring Harbor Laboratory . Since 2007, he has served as Director of Research of CSHL.

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David L. Spector's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

Long noncoding RNAs: functional surprises from the RNA world. (2009) (2124)
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence (2003) (2064)
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. (2013) (1342)
Nuclear speckles: a model for nuclear organelles (2003) (974)
From Silencing to Gene Expression Real-Time Analysis in Single Cells (2004) (695)
Nuclear speckles. (2011) (674)
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression (2010) (656)
Regulating Gene Expression through RNA Nuclear Retention (2005) (648)
The dynamics of a pre-mRNA splicing factor in living cells (1997) (632)
Macromolecular domains within the cell nucleus. (1993) (621)
3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA (2008) (608)
Biogenesis and function of nuclear bodies. (2011) (590)
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. (2009) (574)
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility (2008) (565)
Associations between distinct pre‐mRNA splicing components and the cell nucleus. (1991) (529)
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. (2012) (526)
Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation (2001) (526)
Dynamics of Single mRNPs in Nuclei of Living Cells (2004) (491)
Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences (1992) (472)
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss (2016) (450)
Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity (1997) (448)
Identification of Nuclear Dicing Bodies Containing Proteins for MicroRNA Biogenesis in Living Arabidopsis Plants (2007) (434)
Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. (2007) (433)
Direct Visualization of the Co-transcriptional Assembly of a Nuclear Body by Noncoding RNAs (2010) (424)
A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence (2008) (394)
Therapeutic Targeting of Long Non-Coding RNAs in Cancer. (2018) (388)
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes (2002) (375)
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (2013) (373)
Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. (2004) (354)
Applications of the green fluorescent protein in cell biology and biotechnology (1997) (353)
The dynamics of chromosome organization and gene regulation. (2003) (348)
RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. (1999) (338)
Visualization of gene activity in living cells (2000) (319)
Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo (1998) (291)
In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism (1993) (269)
Purification and biochemical characterization of interchromatin granule clusters (1999) (267)
Proteomic analysis of interchromatin granule clusters. (2004) (265)
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (2005) (257)
The cellular organization of gene expression. (1998) (255)
Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA (2014) (253)
Nuclear domains. (2001) (248)
In vivo analysis of the stability and transport of nuclear poly(A)+ RNA (1994) (237)
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. (2010) (235)
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation (2011) (234)
Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. (1991) (233)
Long non-coding RNAs: modulators of nuclear structure and function. (2014) (225)
Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles. (1990) (218)
Immunoelectron microscopic localization of snRNPs (1983) (200)
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus (2002) (192)
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors (1994) (190)
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy (1994) (185)
Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription (1996) (184)
Differential Regulation of Strand-Specific Transcripts from Arabidopsis Centromeric Satellite Repeats (2005) (179)
Nuclear neighborhoods and gene expression. (2009) (177)
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer (2018) (176)
Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. (1996) (169)
Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis. (1994) (167)
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing (2002) (161)
SnapShot: Cellular Bodies (2006) (161)
Chromatin organization and transcriptional regulation. (2013) (160)
Chromatin Dynamics and Gene Positioning (2008) (153)
The Noncoding RNA MALAT 1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells (2013) (145)
Sequential entry of components of the gene expression machinery into daughter nuclei. (2003) (142)
Nuclear organization and gene expression. (1996) (142)
Time-resolved analysis and visualization of dynamic processes in living cells. (1999) (126)
Nuclear organization of pre-mRNA processing. (1993) (125)
Centromere positioning and dynamics in living Arabidopsis plants. (2005) (122)
The life of an mRNA in space and time (2010) (122)
The Dynamic Organization of the Perinucleolar Compartment in the Cell Nucleus (1997) (122)
U1 and U2 small nuclear RNAs are present in nuclear speckles (1992) (119)
Differences in snRNP localization between transformed and nontransformed cells. (1992) (118)
Protein phosphorylation and the nuclear organization of pre-mRNA splicing. (1997) (116)
Random monoallelic gene expression increases upon embryonic stem cell differentiation. (2014) (114)
Immunocytochemical localization of casein kinase II during interphase and mitosis (1991) (109)
Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements (2013) (103)
PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. (2006) (101)
Redistribution of U-snRNPs during mitosis. (1986) (98)
Lamin A/C is Expressed in Pluripotent Mouse Embryonic Stem Cells (2013) (98)
Random monoallelic expression: regulating gene expression one allele at a time. (2014) (96)
Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. (2005) (88)
Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. (2000) (88)
Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. (2019) (88)
Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. (2004) (87)
The Perinucleolar Compartment and Transcription (1998) (87)
Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. (1995) (83)
MALAT1 Long Non-Coding RNA: Functional Implications (2020) (80)
Regulation of the ESC transcriptome by nuclear long noncoding RNAs (2015) (78)
Compartmentalization of RNA processing factors within nuclear speckles. (2000) (77)
Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. (1993) (77)
Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. (1998) (77)
A Covalent Fluorescent–Gold Immunoprobe: Simultaneous Detection of a Pre-mRNA Splicing Factor by Light and Electron Microscopy (1997) (72)
MALAT1 long non-coding RNA and breast cancer (2019) (70)
Dynamics of transcription and pre-mRNA splicing within the mammalian cell nucleus. (1993) (69)
Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression (2010) (66)
Activating a collaborative innate-adaptive immune response to control metastasis. (2021) (65)
Hsp 104 Catalyzes Formation and Elimination of Self-Replicating Sup 35 Prion Conformers (2004) (64)
Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes (2011) (63)
Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus (1986) (63)
Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei (2004) (59)
Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. (2010) (59)
Dynamic organization of pre‐mRNA splicing factors (1996) (58)
An unexpected ending: noncanonical 3' end processing mechanisms. (2010) (58)
Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis. (2008) (56)
Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. (2008) (51)
Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing (2019) (50)
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression (2020) (50)
Quantitative imaging of pre-mRNA splicing factors in living cells. (2000) (50)
Identification and Characterization of a Class of MALAT1-like Genomic Loci. (2017) (46)
Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. (2015) (45)
Nuclear choreography: interpretations from living cells. (2003) (44)
Receptor-mediated delivery of engineered nucleases for genome modification (2013) (43)
Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus (1990) (42)
Chromatin dynamics. (2010) (40)
Nonrigid Registration of 2-D and 3-D Dynamic Cell Nuclei Images for Improved Classification of Subcellular Particle Motion (2011) (40)
Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. (2016) (39)
Colocalization of U1 and U2 small nuclear RNPs by immunocytochemistry (1984) (38)
The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells (2012) (37)
"On the move"ments of nuclear components in living cells. (2004) (35)
Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107 (1985) (32)
A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (29)
Live cell imaging of plants. (2010) (27)
Erratum: U1 and U2 small nuclear RNAs are present in nuclear speckles (Proc. Natl. Acad. Sci. USA (January 1992) 89 (305-308)) (1992) (18)
Long non-coding RNAs: definitions, functions, challenges and recommendations. (2023) (18)
A molecular dissection of nuclear function (2003) (17)
Organization of RNA polymerase II transcription and pre-mRNA splicing within the mammalian cell nucleus. (1993) (16)
RCC1 and nuclear organization. (1997) (15)
Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data (2015) (15)
Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. (1995) (15)
Will the real splicing sites please light up? (1992) (14)
BiFC imaging assay for plant protein-protein interactions. (2010) (13)
3D segmentation and quantification of mouse embryonic stem cells in fluorescence microscopy images (2011) (13)
NON-RIGID TEMPORAL REGISTRATION OF 2D AND 3D MULTI-CHANNEL MICROSCOPY IMAGE SEQUENCES OF HUMAN CELLS (2007) (13)
Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: Further evidence for an in situ nuclear matrix (1986) (10)
PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (10)
Immunofluorescence localization of nuclear proteins. (2011) (9)
Erratum: Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (EMBO Journal (2004) 23 (2657-2663) (10.1038/sj.emboj.7600255)) (2005) (9)
Cycling splicing factors (1994) (8)
Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics (2021) (7)
Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. (2017) (7)
The nucleus : a subject collection from Cold Spring Harbor Perspectives in biology (2011) (5)
Stopping for FISH and chips along the chromatin fiber superhighway. (2004) (5)
Immunoblot affinity purification (2005) (5)
Chromatin Meets Its Organizers (2013) (5)
Noncoding RNAs: biology and applications—a Keystone Symposia report (2021) (4)
Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. (2022) (4)
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing (1989) (4)
Testing for Phylogenetic Signal in Single-Cell RNA-Seq Data (2021) (4)
Pre-mRNA splicing: Nuclear organization of factors and substrates (1997) (4)
Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis (2020) (3)
Small nuclear RNPs and RNA processing (1982) (2)
Nuclear antigenic structures. (1985) (2)
RNA processing. Cycling splicing factors. (1994) (2)
The Cell Nucleus (2006) (1)
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (2022) (1)
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA-sequencing datasets (2023) (1)
Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2 (2015) (1)
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation. (2023) (1)
Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2 (2015) (1)
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (1)
Four-dimensional imaging of plant cells during the cell cycle. (2010) (1)
Genes and transcripts in the interphase nucleus (1997) (1)
Simultaneous visualization of RNA transcripts and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy (2022) (1)
Abstract 1121: The long non-coding RNA MALAT1 is an essential gene regulator for lung cancer metastasis in a novel human knockout model . (2013) (1)
Resource Identification and Charact erization of a Class of MALAT 1-like Genomic Loci Graphical Abstract Highlights (2017) (0)
Erratum: (Molecular Biology of the Cell (2003) 14 (1043-1057)) (2003) (0)
regulation Myc enhancer-mediated Role of SWI / SNF in acute leukemia maintenance and Material Supplemental (2013) (0)
The standard of care for advanced HCC (2021) (0)
Thedynamicsof apre-mRNA splicing factor in livingcells (0)
Studying Subnuclear Dynamics in Living Cells (2000) (0)
The Role of Long Non‐Coding RNAs in Nuclear Organization and Disease (2017) (0)
Immunolocalization of nuclear antigens in cryofixed cells which have been prepared by molecular distillation drying or freeze-substitution (1990) (0)
ADAR2 edits the CTN-RNA that is retained in the nucleus (2007) (0)
MaTAR25: a long non-coding RNA involved in breast cancer progression (2021) (0)
Identification and characterization of long non-coding RNAs as targets of mammary tumor cell proliferation and migration (2016) (0)
Nuclear Organization & Function (2010) (0)
Author response: PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (0)
The functional organization of RNAs in the mammalian cell nucleus (1995) (0)
563. Analysis of DNA Repair Pathway Choice Upon Induction of Double-Strand Breaks by Engineered Nuclease (2016) (0)
306 Cell Biology : Huang and (0)
pre-mRNA splicing . endogenous complexes during in vitro Multiple splicing factors are released from (2003) (0)
Interchromatin granule clusters are essential for coordinating transcription and pre-mRNA splicing (2001) (0)
The control of splicing factor recruitment to sites of transcription in-vivo (1997) (0)
Abstract A43: Long noncoding RNAs as targets of mammary tumor cell proliferation and migration (2016) (0)
Coordination of Transcription and Pre-Messenger-Rna Splicing within the Cell-Nucleus (1994) (0)
Molecular and Cellular Pathobiology The Noncoding RNA MALAT 1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells (2013) (0)
Autoantibodies as probes for the molecular architecture of the nucleus (1991) (0)
Pre-mRNA splicing factors initially localize around active NORs upon entry into daughter nuclei (2002) (0)
Nuclear dynamics and gene expression (2005) (0)
Author response: A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (0)
Nucleus and gene expression: The interplay of transcriptional mechanisms that regulate gene and post-transcriptional expression (2004) (0)
nucleus . pre-mRNA processing in the yeast cell Differential distribution of factors involved in (0)
Reorganization of the Pre-Messenger-Rna Splicing Apparatus Upon Adenovirus Infection (1992) (0)
Nuclear organization of pre-mRNA splicing factors and their substrates (1994) (0)
Allele pairing at Sun1-enriched domains at the nuclear periphery via T1A3 tandem DNA repeats (2023) (0)
A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition (2017) (0)
Live-cell visualization of the dynamics of chromatin associated factors during the transition from a transcriptionally inactive to an active state (2002) (0)
3-Dimensional Distribution of Small Nuclear Rnps and Reorganization of Small Nuclear Rnp-Enriched Nuclear Regions Upon Alterations in the Level of Transcription (1989) (0)
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (2013) (0)
3-dimensional immunolabeling and in situ hybridization detection using fluorescence photooxidation and intermediate-voltage electron microscopy (1994) (0)
Sequential entry of transcription/RNA processing factors into post-mitotic daughter nuclei (2001) (0)
NUCLEAR RETAINED RNAs REGULATING GENE EXPRESSION (2007) (0)
Probing the organization and function of interchromatin granule clusters (2000) (0)
PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (0)
DNA in Mammalian Cell Nuclei: Spatially and Temporally Defined Replication of Chromosome-specific a-Satellite DNA Sequences (2002) (0)
The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways (2021) (0)
Development of an in vitro system to recapitulate interchromatin granule cluster dynamics (2000) (0)
A Biological Delivery Platform for Zinc Finger Nucleases Using Transferrin-Mediated Endocytosis (2011) (0)
PML Nuclear Body Identification and Ultrastructure in Rodent Tissues and Cultured Cells by Post-Embedding Immunogold Labeling (2002) (0)
Autosomal monoallelic genes are differentially regulated based on parental origin (2022) (0)
Probing the Role of a Highly Expressed Long Non-Coding RNA in Hepatocellular Carcinoma (2016) (0)
Organization of transcription and pre-mRNA splicing within the mammalian cell nucleus (1995) (0)
Visualizing the dynamics of gene expression in living cells (2002) (0)

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