David L. Spector
#62,158
Most Influential Person Now
American cell biologist
David L. Spector's AcademicInfluence.com Rankings
David L. Spectorbiology Degrees
Biology
#5255
World Rank
#7686
Historical Rank
#1847
USA Rank
Cell Biology
#230
World Rank
#238
Historical Rank
#52
USA Rank
Download Badge
Biology
David L. Spector's Degrees
- PhD Cell Biology University of California, Berkeley
- Bachelors Biology Stanford University
Similar Degrees You Can Earn
Why Is David L. Spector Influential?
(Suggest an Edit or Addition)According to Wikipedia, David L. Spector is a cell and molecular biologist best recognized for his research on gene expression and nuclear dynamics. He is currently a professor at Cold Spring Harbor Laboratory . Since 2007, he has served as Director of Research of CSHL.
David L. Spector's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Long noncoding RNAs: functional surprises from the RNA world. (2009) (2124)
- Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence (2003) (2064)
- The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. (2013) (1342)
- Nuclear speckles: a model for nuclear organelles (2003) (974)
- From Silencing to Gene Expression Real-Time Analysis in Single Cells (2004) (695)
- Nuclear speckles. (2011) (674)
- A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression (2010) (656)
- Regulating Gene Expression through RNA Nuclear Retention (2005) (648)
- The dynamics of a pre-mRNA splicing factor in living cells (1997) (632)
- Macromolecular domains within the cell nucleus. (1993) (621)
- 3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA (2008) (608)
- Biogenesis and function of nuclear bodies. (2011) (590)
- MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. (2009) (574)
- 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility (2008) (565)
- Associations between distinct pre‐mRNA splicing components and the cell nucleus. (1991) (529)
- The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. (2012) (526)
- Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation (2001) (526)
- Dynamics of Single mRNPs in Nuclei of Living Cells (2004) (491)
- Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences (1992) (472)
- Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss (2016) (450)
- Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity (1997) (448)
- Identification of Nuclear Dicing Bodies Containing Proteins for MicroRNA Biogenesis in Living Arabidopsis Plants (2007) (434)
- Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. (2007) (433)
- Direct Visualization of the Co-transcriptional Assembly of a Nuclear Body by Noncoding RNAs (2010) (424)
- A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence (2008) (394)
- Therapeutic Targeting of Long Non-Coding RNAs in Cancer. (2018) (388)
- Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes (2002) (375)
- Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (2013) (373)
- Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. (2004) (354)
- Applications of the green fluorescent protein in cell biology and biotechnology (1997) (353)
- The dynamics of chromosome organization and gene regulation. (2003) (348)
- RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. (1999) (338)
- Visualization of gene activity in living cells (2000) (319)
- Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo (1998) (291)
- In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism (1993) (269)
- Purification and biochemical characterization of interchromatin granule clusters (1999) (267)
- Proteomic analysis of interchromatin granule clusters. (2004) (265)
- Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (2005) (257)
- The cellular organization of gene expression. (1998) (255)
- Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA (2014) (253)
- Nuclear domains. (2001) (248)
- In vivo analysis of the stability and transport of nuclear poly(A)+ RNA (1994) (237)
- Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. (2010) (235)
- Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation (2011) (234)
- Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. (1991) (233)
- Long non-coding RNAs: modulators of nuclear structure and function. (2014) (225)
- Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles. (1990) (218)
- Immunoelectron microscopic localization of snRNPs (1983) (200)
- Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus (2002) (192)
- Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors (1994) (190)
- Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy (1994) (185)
- Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription (1996) (184)
- Differential Regulation of Strand-Specific Transcripts from Arabidopsis Centromeric Satellite Repeats (2005) (179)
- Nuclear neighborhoods and gene expression. (2009) (177)
- POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer (2018) (176)
- Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. (1996) (169)
- Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis. (1994) (167)
- Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing (2002) (161)
- SnapShot: Cellular Bodies (2006) (161)
- Chromatin organization and transcriptional regulation. (2013) (160)
- Chromatin Dynamics and Gene Positioning (2008) (153)
- The Noncoding RNA MALAT 1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells (2013) (145)
- Sequential entry of components of the gene expression machinery into daughter nuclei. (2003) (142)
- Nuclear organization and gene expression. (1996) (142)
- Time-resolved analysis and visualization of dynamic processes in living cells. (1999) (126)
- Nuclear organization of pre-mRNA processing. (1993) (125)
- Centromere positioning and dynamics in living Arabidopsis plants. (2005) (122)
- The life of an mRNA in space and time (2010) (122)
- The Dynamic Organization of the Perinucleolar Compartment in the Cell Nucleus (1997) (122)
- U1 and U2 small nuclear RNAs are present in nuclear speckles (1992) (119)
- Differences in snRNP localization between transformed and nontransformed cells. (1992) (118)
- Protein phosphorylation and the nuclear organization of pre-mRNA splicing. (1997) (116)
- Random monoallelic gene expression increases upon embryonic stem cell differentiation. (2014) (114)
- Immunocytochemical localization of casein kinase II during interphase and mitosis (1991) (109)
- Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements (2013) (103)
- PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. (2006) (101)
- Redistribution of U-snRNPs during mitosis. (1986) (98)
- Lamin A/C is Expressed in Pluripotent Mouse Embryonic Stem Cells (2013) (98)
- Random monoallelic expression: regulating gene expression one allele at a time. (2014) (96)
- Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. (2005) (88)
- Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. (2000) (88)
- Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. (2019) (88)
- Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. (2004) (87)
- The Perinucleolar Compartment and Transcription (1998) (87)
- Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. (1995) (83)
- MALAT1 Long Non-Coding RNA: Functional Implications (2020) (80)
- Regulation of the ESC transcriptome by nuclear long noncoding RNAs (2015) (78)
- Compartmentalization of RNA processing factors within nuclear speckles. (2000) (77)
- Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. (1993) (77)
- Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. (1998) (77)
- A Covalent Fluorescent–Gold Immunoprobe: Simultaneous Detection of a Pre-mRNA Splicing Factor by Light and Electron Microscopy (1997) (72)
- MALAT1 long non-coding RNA and breast cancer (2019) (70)
- Dynamics of transcription and pre-mRNA splicing within the mammalian cell nucleus. (1993) (69)
- Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression (2010) (66)
- Activating a collaborative innate-adaptive immune response to control metastasis. (2021) (65)
- Hsp 104 Catalyzes Formation and Elimination of Self-Replicating Sup 35 Prion Conformers (2004) (64)
- Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes (2011) (63)
- Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus (1986) (63)
- Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei (2004) (59)
- Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. (2010) (59)
- Dynamic organization of pre‐mRNA splicing factors (1996) (58)
- An unexpected ending: noncanonical 3' end processing mechanisms. (2010) (58)
- Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis. (2008) (56)
- Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. (2008) (51)
- Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing (2019) (50)
- MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression (2020) (50)
- Quantitative imaging of pre-mRNA splicing factors in living cells. (2000) (50)
- Identification and Characterization of a Class of MALAT1-like Genomic Loci. (2017) (46)
- Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. (2015) (45)
- Nuclear choreography: interpretations from living cells. (2003) (44)
- Receptor-mediated delivery of engineered nucleases for genome modification (2013) (43)
- Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus (1990) (42)
- Chromatin dynamics. (2010) (40)
- Nonrigid Registration of 2-D and 3-D Dynamic Cell Nuclei Images for Improved Classification of Subcellular Particle Motion (2011) (40)
- Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. (2016) (39)
- Colocalization of U1 and U2 small nuclear RNPs by immunocytochemistry (1984) (38)
- The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells (2012) (37)
- "On the move"ments of nuclear components in living cells. (2004) (35)
- Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107 (1985) (32)
- A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (29)
- Live cell imaging of plants. (2010) (27)
- Erratum: U1 and U2 small nuclear RNAs are present in nuclear speckles (Proc. Natl. Acad. Sci. USA (January 1992) 89 (305-308)) (1992) (18)
- Long non-coding RNAs: definitions, functions, challenges and recommendations. (2023) (18)
- A molecular dissection of nuclear function (2003) (17)
- Organization of RNA polymerase II transcription and pre-mRNA splicing within the mammalian cell nucleus. (1993) (16)
- RCC1 and nuclear organization. (1997) (15)
- Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data (2015) (15)
- Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. (1995) (15)
- Will the real splicing sites please light up? (1992) (14)
- BiFC imaging assay for plant protein-protein interactions. (2010) (13)
- 3D segmentation and quantification of mouse embryonic stem cells in fluorescence microscopy images (2011) (13)
- NON-RIGID TEMPORAL REGISTRATION OF 2D AND 3D MULTI-CHANNEL MICROSCOPY IMAGE SEQUENCES OF HUMAN CELLS (2007) (13)
- Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: Further evidence for an in situ nuclear matrix (1986) (10)
- PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (10)
- Immunofluorescence localization of nuclear proteins. (2011) (9)
- Erratum: Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (EMBO Journal (2004) 23 (2657-2663) (10.1038/sj.emboj.7600255)) (2005) (9)
- Cycling splicing factors (1994) (8)
- Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics (2021) (7)
- Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. (2017) (7)
- The nucleus : a subject collection from Cold Spring Harbor Perspectives in biology (2011) (5)
- Stopping for FISH and chips along the chromatin fiber superhighway. (2004) (5)
- Immunoblot affinity purification (2005) (5)
- Chromatin Meets Its Organizers (2013) (5)
- Noncoding RNAs: biology and applications—a Keystone Symposia report (2021) (4)
- Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. (2022) (4)
- Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing (1989) (4)
- Testing for Phylogenetic Signal in Single-Cell RNA-Seq Data (2021) (4)
- Pre-mRNA splicing: Nuclear organization of factors and substrates (1997) (4)
- Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis (2020) (3)
- Small nuclear RNPs and RNA processing (1982) (2)
- Nuclear antigenic structures. (1985) (2)
- RNA processing. Cycling splicing factors. (1994) (2)
- The Cell Nucleus (2006) (1)
- Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (2022) (1)
- Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA-sequencing datasets (2023) (1)
- Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2 (2015) (1)
- Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation. (2023) (1)
- Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2 (2015) (1)
- Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (1)
- Four-dimensional imaging of plant cells during the cell cycle. (2010) (1)
- Genes and transcripts in the interphase nucleus (1997) (1)
- Simultaneous visualization of RNA transcripts and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy (2022) (1)
- Abstract 1121: The long non-coding RNA MALAT1 is an essential gene regulator for lung cancer metastasis in a novel human knockout model . (2013) (1)
- Resource Identification and Charact erization of a Class of MALAT 1-like Genomic Loci Graphical Abstract Highlights (2017) (0)
- Erratum: (Molecular Biology of the Cell (2003) 14 (1043-1057)) (2003) (0)
- regulation Myc enhancer-mediated Role of SWI / SNF in acute leukemia maintenance and Material Supplemental (2013) (0)
- The standard of care for advanced HCC (2021) (0)
- Thedynamicsof apre-mRNA splicing factor in livingcells (0)
- Studying Subnuclear Dynamics in Living Cells (2000) (0)
- The Role of Long Non‐Coding RNAs in Nuclear Organization and Disease (2017) (0)
- Immunolocalization of nuclear antigens in cryofixed cells which have been prepared by molecular distillation drying or freeze-substitution (1990) (0)
- ADAR2 edits the CTN-RNA that is retained in the nucleus (2007) (0)
- MaTAR25: a long non-coding RNA involved in breast cancer progression (2021) (0)
- Identification and characterization of long non-coding RNAs as targets of mammary tumor cell proliferation and migration (2016) (0)
- Nuclear Organization & Function (2010) (0)
- Author response: PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (0)
- The functional organization of RNAs in the mammalian cell nucleus (1995) (0)
- 563. Analysis of DNA Repair Pathway Choice Upon Induction of Double-Strand Breaks by Engineered Nuclease (2016) (0)
- 306 Cell Biology : Huang and (0)
- pre-mRNA splicing . endogenous complexes during in vitro Multiple splicing factors are released from (2003) (0)
- Interchromatin granule clusters are essential for coordinating transcription and pre-mRNA splicing (2001) (0)
- The control of splicing factor recruitment to sites of transcription in-vivo (1997) (0)
- Abstract A43: Long noncoding RNAs as targets of mammary tumor cell proliferation and migration (2016) (0)
- Coordination of Transcription and Pre-Messenger-Rna Splicing within the Cell-Nucleus (1994) (0)
- Molecular and Cellular Pathobiology The Noncoding RNA MALAT 1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells (2013) (0)
- Autoantibodies as probes for the molecular architecture of the nucleus (1991) (0)
- Pre-mRNA splicing factors initially localize around active NORs upon entry into daughter nuclei (2002) (0)
- Nuclear dynamics and gene expression (2005) (0)
- Author response: A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (0)
- Nucleus and gene expression: The interplay of transcriptional mechanisms that regulate gene and post-transcriptional expression (2004) (0)
- nucleus . pre-mRNA processing in the yeast cell Differential distribution of factors involved in (0)
- Reorganization of the Pre-Messenger-Rna Splicing Apparatus Upon Adenovirus Infection (1992) (0)
- Nuclear organization of pre-mRNA splicing factors and their substrates (1994) (0)
- Allele pairing at Sun1-enriched domains at the nuclear periphery via T1A3 tandem DNA repeats (2023) (0)
- A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition (2017) (0)
- Live-cell visualization of the dynamics of chromatin associated factors during the transition from a transcriptionally inactive to an active state (2002) (0)
- 3-Dimensional Distribution of Small Nuclear Rnps and Reorganization of Small Nuclear Rnp-Enriched Nuclear Regions Upon Alterations in the Level of Transcription (1989) (0)
- Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance (2013) (0)
- 3-dimensional immunolabeling and in situ hybridization detection using fluorescence photooxidation and intermediate-voltage electron microscopy (1994) (0)
- Sequential entry of transcription/RNA processing factors into post-mitotic daughter nuclei (2001) (0)
- NUCLEAR RETAINED RNAs REGULATING GENE EXPRESSION (2007) (0)
- Probing the organization and function of interchromatin granule clusters (2000) (0)
- PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR (2021) (0)
- DNA in Mammalian Cell Nuclei: Spatially and Temporally Defined Replication of Chromosome-specific a-Satellite DNA Sequences (2002) (0)
- The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways (2021) (0)
- Development of an in vitro system to recapitulate interchromatin granule cluster dynamics (2000) (0)
- A Biological Delivery Platform for Zinc Finger Nucleases Using Transferrin-Mediated Endocytosis (2011) (0)
- PML Nuclear Body Identification and Ultrastructure in Rodent Tissues and Cultured Cells by Post-Embedding Immunogold Labeling (2002) (0)
- Autosomal monoallelic genes are differentially regulated based on parental origin (2022) (0)
- Probing the Role of a Highly Expressed Long Non-Coding RNA in Hepatocellular Carcinoma (2016) (0)
- Organization of transcription and pre-mRNA splicing within the mammalian cell nucleus (1995) (0)
- Visualizing the dynamics of gene expression in living cells (2002) (0)
This paper list is powered by the following services:
Other Resources About David L. Spector
What Schools Are Affiliated With David L. Spector?
David L. Spector is affiliated with the following schools:
