Denis Noble

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Denis Noble is affiliated with the following schools: University of Oxford, University College London, Osaka University, New York University

Denis Noble's AcademicInfluence.com Rankings

Denis Noble

Biology

#187

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#342

Historical Rank

Physiology

#18

World Rank

#75

Historical Rank

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Why Is Denis Noble Influential?

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According to Wikipedia, Denis Noble is a British physiologist and biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of systems biology and developed the first viable mathematical model of the working heart in 1960. Noble established The Third Way of Evolution project with James A. Shapiro which predicts that the entire framework of the modern synthesis will be replaced.

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Denis Noble's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Electric current flow in excitable cells (1975) (1288)
A model for human ventricular tissue. (2004) (1178)
A modification of the Hodgkin—Huxley equations applicable to Purkinje fibre action and pacemaker potentials (1962) (951)
A model of cardiac electrical activity incorporating ionic pumps and concentration changes. (1985) (861)
Modeling the Heart--from Genes to Cells to the Whole Organ (2002) (621)
Reconstruction of the electrical activity of cardiac Purkinje fibres. (1975) (572)
Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres (1969) (481)
The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres (1968) (479)
The surprising heart: a review of recent progress in cardiac electrophysiology. (1984) (435)
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes. (1998) (374)
Systems Biology: An Approach (2010) (358)
The music of life : biology beyond genes (2008) (317)
Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations (1960) (309)
Music of life : biology beyond the genome (2006) (305)
A theory of biological relativity: no privileged level of causation (2012) (303)
Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models. (1999) (271)
Rectifying Properties of Heart Muscle (1960) (269)
Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk (2011) (267)
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms (1987) (266)
The initiation of the heartbeat (1975) (258)
Computational physiology and the physiome project (2004) (251)
Claude Bernard, the first systems biologist, and the future of physiology (2008) (236)
Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
For a Redefinition of God (2008) (216)
Models of cardiac ventricular action potentials: iterative interaction between experiment and simulation (2001) (212)
The chloride conductance of frog skeletal muscle (1960) (207)
Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium–calcium overload (2006) (206)
The time and voltage dependence of the slow outward current in cardiac Purkinje fibres (1966) (205)
Adrenaline: Mechanism of Action on the Pacemaker Potential in Cardiac Purkinje Fibers (1968) (203)
Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking (2004) (200)
Applications of Hodgkin-Huxley equations to excitable tissues. (1966) (198)
Electrical properties of cardiac muscle attributable to inward going (anomalous) rectification (1965) (197)
The rise of computational biology (2002) (193)
Mechanosensitive fibroblasts in the sino‐atrial node region of rat heart: interaction with cardiomyocytes and possible role (1994) (189)
The IUPS human physiome project (2002) (187)
Systems biology and the virtual physiological human (2009) (179)
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations (1984) (177)
Analytical models of propagation in excitable cells. (1975) (173)
Sodium‐calcium exchange during the action potential in guinea‐pig ventricular cells. (1989) (171)
Anion conductance of cardiac muscle (1961) (170)
The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man (2004) (165)
Current—voltage relations of Purkinje fibres in sodium‐deficient solutions (1963) (163)
Genes and causation (2008) (155)
The Role of Sodium ‐ Calcium Exchange during the Cardiac Action Potential a (1991) (154)
The threshold conditions for initiation of action potentials by excitable cells (1966) (150)
Mathematical models of the electrical action potential of Purkinje fibre cells (2009) (141)
Markov models for ion channels: versatility versus identifiability and speed (2009) (139)
Physiology is rocking the foundations of evolutionary biology (2013) (139)
The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres (1969) (137)
Comments on 'A model for human ventricular tissue' : reply (2005) (135)
Biophysics and systems biology (2010) (135)
The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials (1972) (128)
Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current (1969) (127)
The arrhythmogenic transient inward current iTI and related contraction in isolated guinea‐pig ventricular myocytes. (1987) (126)
A meta‐analysis of cardiac electrophysiology computational models (2009) (126)
Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs (2000) (124)
Conrad Waddington and the origin of epigenetics (2015) (122)
Modelling myocardial ischaemia and reperfusion. (1998) (116)
The interpretation of the T wave of the electrocardiogram. (1978) (114)
Simulating cardiac sinus and atrial network dynamics on the Connection Machine (1993) (113)
A model of the single atrial cell: relation between calcium current and calcium release (1990) (112)
Computational modelling of biological systems: tools and visions (2000) (112)
How the Hodgkin–Huxley equations inspired the Cardiac Physiome Project (2012) (111)
An analysis of the actions of low concentrations of ouabain on membrane currents in Purkinje fibres. (1976) (111)
The Cardiac Physiome: perspectives for the future (2009) (108)
Cellular basis for the T wave of the electrocardiogram (1976) (107)
The initiation of the heart beat. (1966) (104)
Evolution evolves: physiology returns to centre stage (2014) (103)
Modelling the heart: insights, failures and progress. (2002) (101)
Cellular mechanisms of cardiac mechano-electric feedback in a mathematical model. (1998) (101)
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3. (2008) (100)
Contributions of HERG K+ current to repolarization of the human ventricular action potential. (2008) (98)
Ionic mechanisms of action potential prolongation at low temperature in guinea‐pig ventricular myocytes. (1993) (98)
Modeling Cardiac Ischemia (2006) (95)
Evolution beyond neo-Darwinism: a new conceptual framework (2015) (94)
Mechanosensitive connective tissue: potential influence on heart rhythm. (1996) (92)
Modeling the heart. (2004) (91)
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing (2012) (90)
Neo‐Darwinism, the Modern Synthesis and selfish genes: are they of use in physiology? (2011) (90)
Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models. (2003) (90)
Inward current related to contraction in guinea‐pig ventricular myocytes. (1987) (90)
Reciprocal role of the inward currents ib, Na and if in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells (1992) (88)
The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations (1984) (81)
Analysis of the Chronotropic Effect of Acetylcholine on Sinoatrial Node Cells (2002) (81)
One‐Dimensional Rabbit Sinoatrial Node Models: (2003) (80)
Computational models of the heart and their use in assessing the actions of drugs. (2008) (77)
On the mechanism of isoprenaline‐ and forskolin‐induced depolarization of single guinea‐pig ventricular myocytes. (1988) (76)
Cellular Open Resource (COR): a Public CellML Based Environment for Modeling Biological Function (2003) (75)
The slow inward current, isi, in the rabbit sino-atrial node investigated by voltage clamp and computer simulation (1984) (75)
The funny current has a major pacemaking role in the sinus node. (2012) (72)
From the Hodgkin–Huxley axon to the virtual heart (2007) (72)
The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs (2010) (71)
Generation and propagation of ectopic beats induced by spatially localized Na–K pump inhibition in atrial network models (1993) (70)
The voltage dependence of the cardiac membrane conductance. (1962) (69)
Dance to the Tune of Life: Biological Relativity (2017) (69)
Computational biology of the heart: from structure to function. (1998) (69)
Systems biology and the heart. (2006) (66)
Dimensionality in cardiac modelling. (2005) (64)
The Logic of life : the challenge of integrative physiology (1993) (64)
Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised Reporting for Model Reproducibility, Interoperability, and Data Sharing (2011) (63)
Use‐dependent reduction and facilitation of Ca2+ current in guinea‐pig myocytes. (1988) (62)
6 – Sodium–Calcium Exchange and Its Role in Generating Electric Current (1986) (62)
Cellular Open Resource (COR): current status and future directions (2009) (62)
Multiscale modeling: physiome project standards, tools, and databases (2006) (62)
Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node. (2008) (60)
Recent developments in using mechanistic cardiac modelling for drug safety evaluation (2016) (58)
A transition state theory approach to the kinetics of conductance changes in excitable membranes (1969) (52)
The relation of Rushton's ‘liminal length’ for excitation to the resting and active conductances of excitable cells (1972) (52)
An isoprenaline activated sodium-dependent inward current in ventricular myocytes (1987) (52)
Evolution viewed from physics, physiology and medicine (2017) (51)
Regulation of bone metabolism. (2016) (51)
Biological Relativity Requires Circular Causality but Not Symmetry of Causation: So, Where, What and When Are the Boundaries? (2019) (51)
The regulation of intracellular Mg2+ in guinea‐pig heart, studied with Mg(2+)‐selective microelectrodes and fluorochromes (1993) (49)
Effects of gap junction conductance on dynamics of sinoatrial node cells: two-cell and large-scale network models (1994) (48)
The future: putting Humpty-Dumpty together again. (2001) (47)
Mechanical Interaction of Heterogeneous Cardiac Muscle Segments in silico: Effects on CA2+ Handling and Action Potential (2003) (47)
Mechanism of the use dependence of Ca2+ current in guinea‐pig myocytes. (1988) (46)
Chapter 5 – The Repolarization Process of Heart Cells (1972) (44)
Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval–force relations: a modelling study (2006) (44)
Preface to "From the century of the genome to the century of the organism: New theoretical approaches". (2016) (44)
Sodium-calcium exchange (1989) (43)
Differential and integral views of genetics in computational systems biology (2011) (43)
Was the Watchmaker Blind? Or Was She One-Eyed? (2017) (42)
The effects of potassium and temperature on the pace‐maker current, iK2, in Purkinje fibres. (1976) (42)
The role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes. (2008) (42)
Voltage‐ and time‐dependent block of delayed rectifier K+ current in rabbit sino‐atrial node cells by external Ca2+ and Mg2+. (1996) (41)
An account of the foxglove and its medical uses 1785–1985 (1986) (41)
Harnessing stochasticity: How do organisms make choices? (2018) (41)
Ca²⁺-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2²⁺ affirming that increasing SERCA reduces aftercontractions. (2011) (39)
A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification (2000) (39)
The interactions of protons, calcium and potassium ions on cardiac Purkinje fibres. (1978) (39)
The Illusions of the Modern Synthesis (2021) (38)
Contributions of inwardly rectifying K+ currents to repolarization assessed using mathematical models of human ventricular myocytes (2006) (38)
The development of mathematical models of the heart (1995) (38)
Action of salicylate ions on the electrical properties of sheep cardiac Purkinje fibres. (1979) (37)
Adrenergic Control of Cardiac Pacemaker Currents (1975) (37)
Separation of the pace‐maker and plateau components of delayed rectification in cardiac Purkinje fibres (1972) (37)
Effects of rapid changes of external Na+ concentration at different moments during the action potential in guinea‐pig myocytes. (1994) (37)
Reversal potential of the calcium current in bull‐frog atrial myocytes. (1988) (36)
Traditional Knowledge-based Medicine: A Review of History, Principles, and Relevance in the Present Context of P4 Systems Medicine (2017) (36)
The influence of non‐uniformity on the analysis of potassium currents in heart muscle. (1976) (36)
Implications of the Re-Interpretation of iK2 for the Modelling of the Electrical Activity of Pacemaker Tissues in the Heart (1982) (36)
Ionic Mechanisms Determining the Timing of Ventricular Repolarization: Significance for Cardiac Arrhythmias a (1992) (36)
The potassium current activated by 2-nicotinamidoethyl nitrate (nicorandil) in single ventricular cells of guinea pigs (1986) (35)
A biological relativity view of the relationships between genomes and phenotypes. (2013) (34)
Ionic Channels and Effect of Taurine on the Heart (2012) (32)
Displacement of activator thresholds in cardiac muscle by protons and calcium ions. (1978) (32)
Caffeine and tetracaine abolish the slow inward calcium current in sheep cardiac Purkinje fibres [proceedings]. (1979) (31)
A new calcium current underlying the plateau of the cardiac action potential (1984) (31)
The contribution of potassium accumulation to outward currents in frog atrium. (1980) (31)
The effects of low concentrations of cardiotonic steroids on membrane currents and tension in sheep Purkinje fibres (1983) (31)
Successes and failures in modeling heart cell electrophysiology. (2011) (31)
Relationship between the transient inward current and slow inward currents in the sino‐atrial node of the rabbit. (1986) (31)
Competing Oscillators in Cardiac Pacemaking: Historical Background (2010) (30)
Origins of Systems Biology in William Harvey’s Masterpiece on the Movement of the Heart and the Blood in Animals (2009) (30)
The Conditions for Initiating "All-or-Nothing" Repolarization in Cardiac Muscle. (1963) (28)
Considerations for the use of cellular electrophysiology models within cardiac tissue simulations. (2011) (28)
Facilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity. (2000) (28)
Could there be a Synthesis between Western and Oriental Medicine, and with Sasang Constitutional Medicine in Particular? (2009) (27)
Central Dogma or Central Debate? (2018) (27)
Bridging Systems Medicine and Patient Needs (2015) (27)
Unraveling the genetics and mechanisms of cardiac arrhythmia (2002) (27)
Role of Na/Ca exchange and the plasma membrane Ca2+‐ATPase in cell function (2007) (26)
Background inward current in ventricular and atrial cells of the guinea-pig (1993) (25)
High selectivity of the if channel to Na+ and K+ in rabbit isolated sinoatrial node cells (2004) (24)
Reconstructing the heart: a challenge for integrative physiology. (1993) (24)
Resolving the M-cell debate: why and how. (2011) (23)
Exosomes, gemmules, pangenesis and Darwin (2020) (22)
Pharmacodynamic effects in the cardiovascular system: the modeller's view. (2010) (22)
Simulation of Na/Ca Exchange Activity during Ischemia (2002) (21)
Modelling of calcium handling in airway myocytes. (2006) (21)
New trends in evolutionary biology: biological, philosophical and social science perspectives (2017) (21)
The slowing of Ca2+ signals by Ca2+ indicators in cardiac muscle (1991) (21)
A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling (2013) (20)
Rigorous Phenotyping of Cardiac iPSC Preparations Requires Knowledge of Their Resting Potential(s). (2016) (20)
The effect of subthreshold potentials on the membrane current in cardiac Purkinje fibres (1967) (20)
Ionic mechanisms in rhythmic firing of heart and nerve (1985) (19)
Directionality in Drug Action on Sodium–Calcium Exchange (2007) (18)
Novel Approaches to Assessing Cardiac Safety —Proceedings of a Workshop (2011) (18)
Genome Size and Numbers of Biological Functions (2005) (18)
Charles Taylor on teleological explanation (1967) (18)
Systems biology and cancer. (2011) (18)
Editorial: Computational modelling of cell & tissue processes & function (2004) (17)
Modeling of internal pH, ion concentration, and bioenergetic changes during myocardial ischemia. (1997) (17)
Ionic mechanisms controlling the action potential duration and the timing of repolarization. (1986) (17)
The control of calcium current reactivation by catecholamines and acetylcholine in single guinea-pig ventricular myocytes (1987) (17)
What prevents mainstream evolutionists teaching the whole truth about how genomes evolve? (2021) (16)
Will genomics revolutionise pharmaceutical R&D? (2003) (16)
From genes to whole organs: connecting biochemistry to physiology. (2001) (16)
Cardiac action potential repolarization revisited: early repolarization shows all‐or‐none behaviour (2017) (16)
The effects of sodium substitution on currents determining the resting potential in guinea‐pig ventricular cells (1998) (16)
The action of adrenaline on pace‐maker activity in cardiac Purkinje fibres. (1978) (16)
Prologue: mind over molecule: activating biological demons. (2008) (15)
Modelling of sodium-overload arrhythmias and their suppression. (1998) (15)
Evolution beyond neo-Darwinism: a new conceptual framework (2015) (15)
Multistability property in cardiac ionic models of mammalian and human ventricular cells. (2010) (15)
The time course of potassium current following potassium accumulation in frog atrium: analytical solutions using a linear approximation. (1980) (15)
Is it time for in silico simulation of drug cardiac side effects? (2011) (15)
Conductance mechanisms in excitable cells. (1972) (14)
The heart is already working. (2005) (14)
Proceedings: The role of intracellular calcium ion concentration in mediating the adrenaline-induced acceleration of the cardiac pacemaker potential. (1973) (14)
Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system". (2012) (14)
The role of stochasticity in biological communication processes. (2020) (14)
Effect of isoprenaline, carbachol, and Cs+ on Na+ activity and pacemaker potential in rabbit SA node cells. (1999) (14)
Mammalian brain development (2009) (14)
Life and mechanosensitivity. (2008) (14)
The aims of systems biology: between molecules and organisms. (2011) (14)
Functional Roles of Sodium‐Calcium Exchange in Normal and Abnormal Cardiac Rhythm (1996) (13)
Effect of pH on ionic currents underlying pace-maker activity in cardiac Purkinje fibres. (1972) (13)
Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology (2020) (13)
Multi-bio and multi-scale systems biology. (2015) (13)
Influence of Na/Ca Exchange Stoichiometry on Model Cardiac Action Potentials (2002) (12)
Cellular Na+ Homeostasis in the Mammalian Heart: Relationship to Altered Contractility, Rhythm Disturbances, and Defects in Myocyte Metabolism (2006) (12)
How to link genomics to physiology through epigenomics. (2020) (12)
Recent progress and prospects in Sasang constitutional medicine: a traditional type of physiome-based treatment. (2014) (12)
The Evolution and Development of the Universe (2009) (12)
Modeling of molecular and cellular mechanisms involved in Ca2+ signal encoding in airway myocytes (2007) (11)
Can Reasons and Values Influence Action: How Might Intentional Agency Work Physiologically? (2020) (11)
The interaction of ouabain and salicylate on sheep cardiac muscle. (1979) (11)
Comparative study of rabbit sino-atrial node cell models (2002) (11)
Systemic integration of different inheritance systems (2019) (11)
Epilogue: Some conceptual foundations of systems biology. (2013) (10)
Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing (2017) (10)
Transient Responses of Purkinje Fibres to Non-uniform Currents (1963) (10)
Resistance of Cardiac Cells to NCX Knockout (2007) (10)
The effects of prenylamine on single ventricular myocytes of guinea‐pig (1988) (10)
Another hazard of pierced ears. (1979) (9)
Vagal control of heart rate is modulated by extracellular potassium. (1999) (9)
Functional Significance of Na+/Ca2+ Exchangers Co‐localization with Ryanodine Receptors (2007) (9)
Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials. (1969) (9)
Why integration? (2012) (9)
Ascending aortic stenosis selectively increases action potential‐induced Ca2+ influx in epicardial myocytes of the rat left ventricle (2005) (9)
THE EFFECT OF EPINEPHRINE AND COMPETITION BETWEEN MALES ON THE IN VITRO METABOLISM OF RABBIT TESTIS. (1964) (9)
Cellular Darwinism: Regulatory networks, stochasticity, and selection in cancer development. (2021) (9)
Editorial: Charles Darwin, Jean-Baptiste Lamarck, and 21st century arguments on the fundamentals of biology. (2020) (8)
Na-Ca exchange current during the cardiac action potential. (1992) (8)
Glycoside induced inotropism of the heart-more than one mechanism [proceedings]? (1977) (8)
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability (2022) (8)
The Western and Eastern thought traditions for exploring the nature of mind and life. (2017) (8)
A Historical Perspective on the Development of Models of Rhythm in the Heart (2011) (7)
Systems: What's in a name? (2011) (7)
Plenary discussion of the conceptual foundations of systems biology. (2013) (7)
Conceptual foundations of systems biology. (2013) (7)
Systems biology, the Physiome Project and oriental medicine (2009) (7)
Focussed Issue - Mechano-electric feedback and cardiac arrhythmias - Editor's note (2003) (7)
Modelling large SA node-atrial cell networks on a massively parallel computer (1992) (7)
Kinetics of slow component of potassium current in cardiac purkinje fibres. (1968) (7)
The effects of static magnetic field on action potential propagation and excitation recovery in nerve. (2005) (7)
The conceptualist view of teleology (1967) (7)
'In silico' simulation of biological processes. Chair's introduction. (2002) (6)
The surprising heart revisited an early history of the funny current with modern lessons. (2020) (6)
Ion channels: Growing evidence for the role in disease (2010) (6)
Systems Biology Beyond the Genome (2017) (6)
Reduction and integration in understanding the heart. (1998) (6)
Central tenets of neo-Darwinism broken. Response to ‘Neo-Darwinism is just fine’ (2015) (6)
Activity dependent changes in mammalian ventricular muscle [proceedings]. (1977) (6)
Non‐Muscarinic and Non‐Nicotinic Inhibition by the Acetylcholine Analogue Carbachol of the Delayed Rectifier Potassium Current, ik, in Rabbit Isolated Sino‐Atrial Node Cells (1999) (6)
Effects of gap junction conductance on oscillation properties of coupled sino-atrial node cells (1992) (6)
The Einthoven string galvanometer and the interpretation of the T wave of the electrocardiogram [proceedings]. (1976) (5)
Effect of isoprenaline, carbachol, and Cs+ on Na+ activity and pacemaker potential in rabbit SA node cells. (1999) (5)
Experimental and theoretical work on excitation and excitation-contraction coupling in the heart (1987) (5)
What is it to be Conscious (2014) (5)
Electrophysiology of single cardiac cells (1987) (5)
Ionic mechanisms of rhythmic firing. (1983) (5)
The Landscape of Physiology. (2016) (5)
Oita International Electrocardiology Symposium 2000 “Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside” (2000) (5)
Internal K ions modulate the action of external cations on hyperpolarization-activated inward current in rabbit isolated sinoatrial node cells (1993) (5)
Against the microfoundation hegemony: cooperation in biology, business and economics. (2019) (5)
Scale Relativity: an Extended Paradigm for Physics and Biology? (2011) (5)
Mind over Molecule: Systems Biology for Neuroscience and Psychiatry (2010) (5)
Noble model (2008) (5)
Discrimination of transiently applied mechanical loads: breathing vs. pulling. (1994) (5)
Remodelling of calcium dynamics in guinea-pig ventricular cells (2001) (5)
What Future for Evolutionary Biology? Response to Commentaries on “The Illusions of the Modern Synthesis” (2021) (5)
Adrenergic control of cardian pacemaker currents. (1975) (4)
The heart cell in silico: successes, failures and prospects. (2002) (4)
The relationship between the transient inward current (TI) and other components of slow inward current in mammalian cardiac muscle. (1986) (4)
Meeting Report on the 2nd MEI International Symposium - The Worldwide Challenge to Physiome and Systems Biology and Osaka Accord -. (2008) (4)
Rate-dependent activation failure in isolated cardiac cells and tissue due to Na+ channel block. (2015) (4)
Forum for scientific method in biology: transcript (2009) (4)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight (2020) (4)
Heart Rate Slowing by If Current Inhibition (2007) (4)
Cardiovascular research funding in Europe: the United Kingdom. Interview by Jennifer Taylor. (2008) (4)
Modelling of Ca2+-Activated Chloride Current in Tracheal Smooth Muscle Cells (2001) (4)
Is the whole different from the sum of its parts? A proposed procedure for measuring divergence from additivity (2018) (4)
Incorporation of sarcolemmal calcium transporters into the Shorten et al. (2007) model of skeletal muscle: equations, coding, and stability (2020) (4)
How the Hodgkin cycle became the principle of biological relativity (2022) (4)
Chair's Introduction (2008) (4)
Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning (2020) (4)
Mathematics and biology: The ultimate interface? (2015) (4)
Antiarrhythmic drugs (handbook of experimental pharmacology, vol. 89) (1990) (4)
A-Mergence of Biological Systems (2019) (3)
Heart Simulation, Arrhythmia, and the Actions of Drugs (2008) (3)
The influence of voltage non-uniformity on the determination of Erev for iK2. (1979) (3)
The Selected Papers of Denis Noble CBE FRS: A Journey in Physiology Towards Enlightenment (2012) (3)
Introduction for bioinspiration (2015) (3)
Function Forms from the Symmetry Between Order and Disorder (2020) (3)
The Value of Treating Cancer as an Evolutionary Disease. (2021) (3)
Progress in biophysics and molecular biology: A brief history of the journal. (2018) (3)
Incorporating Local Ca2+ Dynamics into Single Cell Ventricular Models (2008) (3)
Life changes itself via genetic engineering: comment on "How life changes itself: the Read-Write (RW) genome" by James Shapiro. (2013) (3)
Multilevel Modeling in Systems Biology (2006) (3)
Dynamics of Cardiac Intracellular CA2+ Handling - from Experiments to Virtual Cells (2003) (3)
Commentary on Scherrer and Jost (2007) Gene and genon concept: coding versus regulation (2009) (3)
Characterization of Na/Ca exchange in plasmalemmal vesicles from zona fasciculata cells of the bovine adrenal gland. (2000) (3)
Cardiac arrhythmogenesis is a major clinical problem. (2008) (3)
The electrogenic Na-K pump current and actions of the cardiac glycosides. (1984) (3)
Rehabilitation of Karl Popper’s Ideas on Evolutionary Biology and the Nature of Biological Science (2021) (3)
Review of historic article: Ebashi, S & Endo, M. 1968 Calcium Ion and Muscle Contraction. Progress in Biophysics and Molecular Biology, 18, 123-183. (2022) (2)
Modern physiology vindicates Darwin's dream (2022) (2)
Is a scientific boycott ever justified? (2003) (2)
Physiology without borders 2. (2012) (2)
Knowledge capture and the responsibility: past and present. (2008) (2)
A survey on linear relations between main electrical components during action potential in ventricular cell (2007) (2)
New index for categorising cardiac reentrant wave: in silico evaluation. (2011) (2)
Comparison of Step and Ramp Voltage Clamp on Background Currents in Guinea‐Pig Ventricular Cells (1999) (2)
Is a scientific boycott ever justified? (2003) (2)
Commentary: physiology is the logic of life. (2004) (2)
Funding the pink diamonds: a historical perspective (2010) (2)
We are still saving British science from Margaret Thatcher (2013) (2)
The Principle of Biological Relativity: Origins and Current Status (2021) (2)
Is the genome the “book of life”?: Denis Noble contends that if the human genome is the book of life it has enormous gaps in it, and that a good omelette is more than just the sum of its ingredients! (2002) (2)
Model of skeletal muscle cramp and its reversal (2020) (2)
The influence of non-uniformity on the analysis of potassium currents in atrial muscle. (1975) (2)
Background current, ib,Na, in guinea-pig ventricular cells (1992) (2)
Proceedings: The influence of extracellular potassium ions on the action of ouabain on membrane currents in sheep Purkinje fibres. (1975) (2)
Implications of electrogenic Na/Ca exchange in mammalian heart: Computer model (1983) (2)
Biological relativity revisited: the pre-eminent role of values. (2022) (2)
Rabbit sino-atrial node modeling: from single cell to tissue structure (2003) (2)
On the time course of extracellular ion concentration changes in frog atrium [proceedings]. (1979) (2)
A global sensitivity tool for cardiac cell modeling: Application to ionic current balance and hypertrophic signaling (2010) (2)
Potassium currents and repolarization reserve in mathematical models of human ventricle (2005) (1)
Behaviour of neural and renal (Na+, K+)- ATPase to dopamine and amphetamine (2011) (1)
Editorial for Progress in Biophysics. (2019) (1)
A Tribute to Ewald Weibel. (2019) (1)
Editorial: 2020 – The year of viruses (2020) (1)
Leonardo da Vinci and the origin of semen (2014) (1)
Half a Century of IUPS. (2018) (1)
Electrical properties of biological cells (1978) (1)
Editorial: The Tribute of Physiology for the Understanding of COVID-19 Disease (2021) (1)
Introduction to the Study and Role of Background Current Mechanisms in the Heart (1993) (1)
Auckland whole heart model: An integrated computational framework for the construction of a whole organ model of cardiac function (2001) (1)
Actions of a multi-component medication, SKT, on skeletal, smooth and cardiac muscle (2015) (1)
Potential antiarrhythmic effects of paeoniflorin and paeonol extracted from the paeoniaceae family (2013) (1)
Correction for Hunter et al., Integrative models of the heart: achievements and limitations (2001) (1)
Advanced computational model of central and peripheral rabbit sino-atrial node cells (2000) (1)
Proceedings: The effects of ouabain on interval duration relationships in sheep Purkinje fibres. (1976) (1)
Editorial for Progress in Biophysics and Molecular Biology. (2019) (1)
The use of sodium salicylate to counter glycoside toxicity [proceedings]. (1976) (1)
Modelling of cardiac rhythm: from single cells to massive networks (1992) (1)
Review of historic article: Huxley 1957 Muscle Structure and theories of contraction. Progress in Biophysics and biophysical chemistry, 7, 255-318. (2022) (1)
Action by Shakuyaku‐kanzo‐to (SKT) and one of its Chemical Components, Glycyrrhetic acid (GA), on Calcium Influx through L‐type Calcium Channel (2016) (1)
The U.S. transition from muscle extension to brain expansion (1976) (1)
George Henry Lewes, George Eliot and the Physiological Society [proceedings]. (1976) (1)
Special issue on "Toward physiome based therapeutics". (2014) (1)
Workshop summary and concluding remarks (2003) (1)
Science and Economic Policy in the United Kingdom (1993) (1)
Progress in Biophysics and Molecular Biology: Editorial (2005) (1)
Calcium movements during each heart beat (1989) (1)
The Nerve Impulse (1974) (1)
Silvio Weidmann: laying the foundations for unravelling the mechanism of heart rhythm (2023) (1)
Marie Curie. Half-life of a legend. (1993) (1)
More on physiology without borders. (2013) (1)
Erratum to: Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology (2020) (1)
Reply to the Editor–Mechanoelectrical factors in M-cell debate (2011) (0)
PBMB Commentary on Editorial by Keith Baverstock (2019) (0)
Systems biology and reproduction. (2013) (0)
Simulation of the anti-arrhythmic properties of herbal remedies (2013) (0)
ESSAY REVIEW FUNDING THE PINK DIAMONDS: A HISTORICAL PERSPECTIVE (2015) (0)
Theoretical modelling of plasma membrane conductances and potential in airway myocyte (2005) (0)
Obituary: R Jean Banister (1917–2013) (2013) (0)
“Background” channels and carriers in the heart (1990) (0)
[Excitation-contraction coupling: role of ionic currents and of ionic pumps (author's transl)]. (1980) (0)
Pharmacological studies of Mudanpi and its main active component on cardiac ischemia and ion channels (2013) (0)
CALCIUM CURRENT OF SINGLE GROUND SQUIRREL AND GUINEA-PIG VENTRICULAR MYOCYTES (1991) (0)
生理学: Studying the logic of life in China: An oriental view on what physiology is about (2015) (0)
Editorial for volume 172. (2022) (0)
Correction to: Neither Dogmas nor Barriers are Absolute (2022) (0)
Reply from Denis Noble: What did Alan Hodgkin know? (2023) (0)
Any questions: Is there a molecular explanation of heart rhyrhm? (1997) (0)
Differential and Integral Views of Gene-Phenotype Relations: A Systems Biological Insight (2012) (0)
The effect of Mudanpi and its main active component on cardiac ischemia and ion channels (2013) (0)
Data bias (2021) (0)
IUPS outreach strategy. Stage 1: outreach to member societies. (2010) (0)
Gregor Mendel at the source of genetics and systems biology (2022) (0)
Correction to: Neither Dogmas nor Barriers are Absolute (2022) (0)
Introducing Drug Action into Single-Cell Cardiac Models (2010) (0)
Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences: 359 (1783) (2001) (0)
What does the Physiome project have to offer (2004) (0)
THE MECHANISMS OF CARDIAC ARRHYTHMIA (1985) (0)
Importance of parameter control in cardiac models for robust pro-arrhythmic risk prediction (2016) (0)
of in Cardiac Pacemaking: Competing Oscillators in Cardiac Pacemaking Historical Background (2010) (0)
Evolution in Revolution (2020) (0)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: 3 approved with reservations] (2021) (0)
Epigenetics and a Relativistic Theory of Evolution (2017) (0)
Genes as physiological prisoners (2000) (0)
Forum: Artificial Intelligence, Artificial Agency and Artificial Life (2019) (0)
The international dimensions of the physiological sciences: The world has grown smaller. But the need for language skills, cultural understanding – and the International Union of Physiological Sciences – is undiminished. (2013) (0)
Mechanisms of murine sino-atrial node pacemaking: the usual suspects (2001) (0)
Welcome to Drug Discovery Today: Disease Models (2004) (0)
Multiple actions via systems biology - ten principles of systems biology and biological relativity (2013) (0)
Edward E. Carmeliet, MD, PhD (January 4, 1930-April 5, 2021): A pioneer in cardiac cellular electrophysiology. (2021) (0)
(Editors). Special Issue on Computational Modelling of Cell & Tissue Processes & Function. (2004) (0)
Nature and Origin of Cells (2017) (0)
Effect of adrenaline on the potassium current reversal potential in cardiac Purkinje fibres of the sheep [proceedings]. (1977) (0)
Simulation of L-Type Calcium Currents using Different Experimental Data Sources: from Cell Line to iPS-Derived Cardiomyocyte (2016) (0)
Models and reality: The role of computational biology (2005) (0)
Incorporation of cellular models of arrythmia into multidimensional cardiac models (2000) (0)
The Music of Life: a systems biology view of Buddhist concepts of the self/no-self (2017) (0)
Electrophysiological features of murine sino-atrial node in relation to the role of i(Na). (2003) (0)
Multilevel systems biology: Theory and practice (2008) (0)
THE L-TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES (2009) (0)
Plenary Lectures (2000) (0)
Editorial: Seventieth Birthday Celebrations. (2021) (0)
International Symposium on QT Prolongation and Ventricular Arrhythmias (1990) (0)
Integrative biology: real science through e-Science (2006) (0)
What can physiology learn from systems biology and evolutionary biology (2014) (0)
Qualia and private languages: Denis Noble explains the ‘private language argument’, where philosophy and neurobiology meet head-on (2004) (0)
PRINCIPLES OF SYSTEMS BIOLOGY AND THE FUTURE OF PHYSIOLOGY (2009) (0)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: awaiting peer review] (2020) (0)
Ion Transport in Heart. L. J. Mullins (1982) (0)
Dancing Nucleotides: Natural Genetic Engineering (2017) (0)
Cardiovascular research funding experiences (2009) (0)
sinoatrial node cells spontaneous pacemaker activity in rabbit isolated Selected Contribution: Axial stretch increases (2013) (0)
CELL-SIGNALING TOOLS : A CASCADE OF KINASES, PHOSPHATASES, AND CYTOKINES (1999) (0)
Outreach, outreach, outreach. (2010) (0)
Cardiac pacemaker activity : from single cells to modelling the heart (1993) (0)
P4-23: Local regulation of SR ca2+ release via Na+/Ca2+ exchanger (2006) (0)
Mind, rationality, and cognition: An interdisciplinary debate (2017) (0)
The Relativity of Epistemology: The Meaning of It All (2017) (0)
Birmingham 2013 and beyond. (2014) (0)
Global Sensitivity Analysis of Arrhythmic Risk Biomarkers in Cardiac Single Cell Models (2012) (0)
Mr George Eliot. A Biography of George Henry Lewes. By David Williams. Pp. 289. (Hodder & Stoughton, London, 1983.) £12.95 (1984) (0)
High selectivity of the i(f) channel to Na+ and K+ in rabbit isolated SA node cells (1993) (0)
Cellular mechanisms of arrhythmia (1990) (0)
Cell signalling in the control of ‘background’ channels and carriers in the heart (1990) (0)
Exosomes in disease: Epigenetic signals from the nervous system to the rest of the organism (2019) (0)
Modelling cardiac alternans (2001) (0)
IUPS and the future of physiology. (2015) (0)
COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight (2020) (0)
Science between convictions and responsability (1997) (0)
The data-hypothesis relationship (2021) (0)
The Language of Symmetry (2023) (0)
Obituary: Otto F Hutter (1924 – 2020) (2021) (0)
What do Intentions do? (2021) (0)
Scientific Introduction (2021) (0)
Anatomically and biophysically detailed computer model of rabbit sino-atrial node pacemaking (2002) (0)
Intentional Action and Physiology (2021) (0)
Review of historic article: Skou 1964 enzymatic aspects of active linked transport of Na+ and K+ through the cell membrane. Progress in Biophysics and Molecular Biology, 14, 133-166. (2022) (0)
Origins and demise of selfish gene theory. (2022) (0)
Erratum to: Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology (2020) (0)
Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology (2019) (0)
A model of skeletal muscle showing the process of cramp and the mechanism of its relief (2019) (0)
Review of historic article: Butler, J.A.V., Johns, E.W. and Philips, D. M. P. 1968. Recent investigations on histones and their functions. Progress in Biophysics and molecular biology, 18, 209-244. (2022) (0)
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability (2022) (0)
Blind Chance and Natural Selection (2016) (0)
Stoichiometry: A discussion (2002) (0)
J. K. Aronson, An account of the foxglove and its medical uses 1785–1985, Oxford University Press, 1985, 8vo, pp. x, 399, £25.00. (1986) (0)
Requirement of brain and cardiac-type sodium channels for murine sinoatrial node pacemaking (2004) (0)
Kathy Wilkes, Teleology, and the Explanation of Behaviour (2022) (0)
Antiarrhythmic drugs (Handbook of experimental pharmacology, vol. 89): edited by E. M. Vaughan Williams, Springer Verlag, 1989. DM 480.00 (v + 650 pages) ISBN 3 540 19239 5 (1990) (0)
Pedro Brugada and Peter Schwartz share the Lefoulon-Delalande Foundation Scientific Prize 2019. (2019) (0)
Tools for optimising experiments and developing predictive models: an example for ion channel kinetics (2009) (0)
Anatomico-physiological model of rabbit sino-atrial node implemented using cellular open resource (COR) (2003) (0)
Routine e-Science with the Nimrod Tools : Recent Applications (2007) (0)
Mathematical modelling of mechanical effects on action potential duration in heterogeneous myocardium (2002) (0)
Commentary (1996) (0)
Cellular open resource (COR): a new environment for cellular and multicellular modelling of cardiac electrophysiology (2002) (0)
In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted? (2014) (0)
Editorial for Volume 169. (2022) (0)
Systems biology of the heart (2005) (0)
Mechanoelectrical factors in M-cell debate (2011) (0)
The Evolution of Consciousness and Agency (2022) (0)
The Universe and the Principle of Relativity (2016) (0)
The functional significance of sodium-calcium exchange (1996) (0)
Obituary: Peter Christopher Fahy 1948-2001 (2001) (0)
Editorial for transmural gradients issue. (2016) (0)
A cascade of falling dogmas? Brazil 2017 beckons with the theme The Rhythms of Life: 1–5 August 2017, RIOCENTRO Exhibition & Convention Centre, Rio de janeiro, Brazil (2017) (0)
The Nobel Prize for medicine and physiology, 2019 (2019) (0)
General Introduction (2021) (0)
The point McIntyre project in Alaska (1995) (0)
What are the challenges and opportunities ahead of any regulatory requirements for in silico cardiac pro-arrhythmia prediction? (2016) (0)
Focussed issue: computational biophysics (2002) (0)
Neither Dogmas nor Barriers are Absolute (2022) (0)
Lost in translation (2018) (0)
Biological Scales and Levels (2017) (0)
Foreword to the Third Edition (2001) (0)
Extracellular potassium may potentiate the action of a multi-component medication, SKT, in skeletal muscle (2015) (0)
Prologue (2008) (0)
Focussed issue: Annotating the genome (2002) (0)
Rio 2017 is Shaping Up as a Great World Congress. (2017) (0)
Normal and Abnormal Conduction in the Heart. Edited by Antonio Paes de Carvalho, Brian F. Hoffman and Melvyn Lieberman. Pp. 510. (Futura Publishing Company, 1982.) $81.60 (1984) (0)
The Ethics of Life (1997) (0)

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