Frances Arnold
#3,586
Most Influential Person
Nobel prize winning US scientist and engineer, (1956 - ), Edgewood, Pennsylvania, USA
Frances Arnold's AcademicInfluence.com Rankings
Chemistry
#186
World Rank
#407
Historical Rank
#103
USA Rank
Chemical Engineering
#26
World Rank
#33
Historical Rank
#18
USA Rank
Organic Chemistry
#127
World Rank
#170
Historical Rank
#48
USA Rank
Why Is Frances Arnold Influential?
(Suggest an Edit or Addition)By AI Staff
Areas of Specialization: Chemical Engineering, Biochemistry and Molecular Biophysics, Biochemistry, Chemical Biology, Organic Chemistry
Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering, and Biochemistry for the California Institute of Technology. She earned a B.S. in mechanical and aerospace engineering from Princeton University and an M.S. and Ph.D in chemical engineering from the University of California, Berkeley. She earned a Nobel Prize in Chemistry for her discovery of methods of using directed evolution to facilitate enzyme development.
Some of the enzymes she has been able to develop with directed evolution are enzymes to produce environmentally friendly pharmaceuticals and renewable fuels. Other enzymes have evolved to provoke cyclopropanation and nitrene transfer reactions.
In addition to the Nobel Prize, she has also received the honor of being the first woman to be chosen for the National Academy of Medicine, the National Academy of Engineering, and the National Academy of Sciences. She won the Millenium Technology Prize in 2016 and the Raymond and Beverly Sackler Prize in Convergence Research in 2017.
Arnold was Inducted into the National Inventors Hall of Fame in 2014 and became an International fellow of the Royal Academy of Engineering in 2018. Most recently, Pope Francis made her a member of the Pontifical Academy of Sciences, a scientific academy located in the Vatican City.
Featured in Top Influential Engineers Today, Top Influential Chemists Today, and Top Women in STEM
According to Wikipedia, Frances Hamilton Arnold is an American chemical engineer and Nobel Laureate. She is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology . In 2018, she was awarded the Nobel Prize in Chemistry for pioneering the use of directed evolution to engineer enzymes.
Frances Arnold's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- Dynamic pattern formation in a vesicle-generating microfluidic device. (2001) (1772)
- A synthetic multicellular system for programmed pattern formation (2005) (1131)
- Protein stability promotes evolvability. (2006) (982)
- A microfabricated fluorescence-activated cell sorter (1999) (888)
- Exploring protein fitness landscapes by directed evolution (2009) (865)
- Engineering microbial consortia: a new frontier in synthetic biology. (2008) (785)
- Why highly expressed proteins evolve slowly. (2005) (738)
- Molecular evolution by staggered extension process (StEP) in vitro recombination (1998) (721)
- Programmed population control by cell–cell communication and regulated killing (2004) (676)
- Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat (2005) (600)
- Directed Evolution: Bringing New Chemistry to Life (2017) (583)
- Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes (2013) (547)
- A synthetic Escherichia coli predator–prey ecosystem (2008) (520)
- Design by Directed Evolution (1998) (507)
- An integrated microfabricated cell sorter. (2002) (505)
- Directed evolution of a thermostable esterase. (1998) (484)
- Directed evolution of a genetic circuit (2002) (466)
- Metal-Affinity Separations: A New Dimension in Protein Processing (1991) (444)
- Machine-learning-guided directed evolution for protein engineering (2018) (441)
- Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. (1993) (434)
- Combinatorial and computational challenges for biocatalyst design (2001) (407)
- Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents (1996) (395)
- How enzymes adapt: lessons from directed evolution (2001) (388)
- Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution. (2015) (378)
- Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life (2016) (374)
- Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation (1999) (369)
- Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase (2002) (365)
- Protein building blocks preserved by recombination (2002) (352)
- Directed evolution of biocatalysts. (1999) (341)
- Thermodynamic prediction of protein neutrality. (2004) (341)
- Evolving strategies for enzyme engineering. (2005) (333)
- Molecular breeding of carotenoid biosynthetic pathways (2000) (333)
- In the light of directed evolution: Pathways of adaptive protein evolution (2009) (331)
- Directed evolution of enzyme catalysts. (1997) (331)
- Inverting enantioselectivity by directed evolution of hydantoinase for improved production of l-methionine (2000) (310)
- Directed enzyme evolution: climbing fitness peaks one amino acid at a time. (2009) (309)
- Directed evolution converts subtilisin E into a functional equivalent of thermitase. (1999) (304)
- Directed enzyme evolution. (2001) (303)
- Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. (2003) (293)
- Engineering new catalytic activities in enzymes (2020) (285)
- Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution (2003) (263)
- Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide. (1996) (260)
- Machine learning-assisted directed protein evolution with combinatorial libraries (2019) (258)
- Cytochrome P450: taming a wild type enzyme. (2011) (249)
- Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. (2011) (248)
- A family of thermostable fungal cellulases created by structure-guided recombination (2009) (247)
- Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme. (2017) (246)
- Directed evolution study of temperature adaptation in a psychrophilic enzyme. (2000) (244)
- Libraries of hybrid proteins from distantly related sequences (2001) (236)
- A Serine-Substituted P450 Catalyzes Highly Efficient Carbene Transfer to Olefins In Vivo (2013) (234)
- Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium (2007) (232)
- Optimizing non-natural protein function with directed evolution. (2011) (231)
- Navigating the protein fitness landscape with Gaussian processes (2012) (226)
- Optimization of DNA shuffling for high fidelity recombination. (1997) (220)
- Enzymatic functionalization of carbon-hydrogen bonds. (2011) (220)
- Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. (2007) (216)
- Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution (2005) (210)
- Exploring Nonnatural Evolutionary Pathways by Saturation Mutagenesis: Rapid Improvement of Protein Function (1999) (210)
- Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture). (2019) (199)
- Engineered metal-binding proteins: purification to protein folding. (1991) (197)
- Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo. (2013) (196)
- A self-sufficient peroxide-driven hydroxylation biocatalyst. (2003) (193)
- Directed evolution of industrial enzymes. (1999) (191)
- Learned protein embeddings for machine learning (2018) (190)
- Directed enzyme evolution : screening and selection methods (2003) (188)
- Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. (2017) (187)
- Computational method to reduce the search space for directed protein evolution (2001) (187)
- Evolutionary history of a specialized p450 propane monooxygenase. (2008) (186)
- Laboratory evolution of cytochrome P450 BM‐3 monooxygenase for organic cosolvents (2004) (186)
- A structural view of evolutionary divergence. (1999) (184)
- Genetically programmed chiral organoborane synthesis (2017) (178)
- Structural determinants of the rate of protein evolution in yeast. (2006) (177)
- Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry (2014) (175)
- Enzyme Engineering for Nonaqueous Solvents: Random Mutagenesis to Enhance Activity of Subtilisin E in Polar Organic Media (1991) (175)
- Random-priming in vitro recombination: an effective tool for directed evolution. (1998) (174)
- Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR (2006) (171)
- The Temkin isotherm describes heterogeneous protein adsorption. (1995) (162)
- Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization (2018) (158)
- A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments (2007) (155)
- Controlling macromolecular topology with genetically encoded SpyTag-SpyCatcher chemistry. (2013) (155)
- Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl‐homoserine lactones (2004) (154)
- Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. (2004) (154)
- Temperature adaptation of enzymes: lessons from laboratory evolution. (2000) (152)
- Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences. (1997) (152)
- Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. (2014) (148)
- Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 (2006) (147)
- Direct Conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3 (2005) (147)
- Designed evolution of enzymatic properties. (2000) (147)
- Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution (2007) (144)
- Library analysis of SCHEMA‐guided protein recombination (2003) (144)
- General method for sequence-independent site-directed chimeragenesis. (2003) (141)
- Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine (2010) (139)
- Directed evolution: new parts and optimized function. (2009) (138)
- Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450. (2006) (137)
- Formation of indigo by recombinant mammalian cytochrome P450. (1999) (137)
- Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation (2001) (135)
- Synthetic gene circuits: design with directed evolution. (2007) (135)
- Enzymatic construction of highly strained carbocycles (2018) (135)
- Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. (2006) (134)
- Optimizing industrial enzymes by directed evolution. (1997) (133)
- Directed evolution library creation : methods and protocols (2003) (132)
- A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. (2009) (132)
- Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution* (2000) (132)
- Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450 (2015) (131)
- Metal-coordination interactions in the template-mediated synthesis of substrate-selective polymers recognition of bis(imidazole) substrates by copper(II) iminodiacetate containing polymers (1992) (130)
- Multiple-site binding interactions in metal-affinity chromatography. I. Equilibrium binding of engineered histidine-containing cytochromes c. (1994) (127)
- Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae. (2001) (127)
- METAL-INDUCED DISPERSION OF LIPID AGGREGATES : A SIMPLE, SELECTIVE, AND SENSITIVE FLUORESCENT METAL ION SENSOR (1995) (125)
- Engineering enzymes for non-aqueous solvents. (1990) (125)
- Analysis of affinity separations: I: Predicting the performance of affinity adsorbers (1985) (122)
- Archaerhodopsin Variants with Enhanced Voltage Sensitive Fluorescence in Mammalian and Caenorhabditis elegans Neurons (2014) (122)
- Design and Evolution of Enzymes for Non-natural Chemistry (2017) (122)
- Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination (2014) (121)
- Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris. (2000) (120)
- Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis (2017) (119)
- Protein engineering of oxygenases for biocatalysis. (2002) (115)
- Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds. (2014) (114)
- Molecularly imprinted ligand-exchange adsorbents for the chiral separation of underivatized amino acids (1997) (113)
- Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures (2013) (113)
- Thermostabilization of a Cytochrome P450 Peroxygenase (2003) (113)
- Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution. (2001) (111)
- Expanding P450 catalytic reaction space through evolution and engineering. (2014) (111)
- SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability* (2009) (109)
- A glucose-sensing polymer (1997) (109)
- Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach. (2004) (108)
- Chemo-enzymatic fluorination of unactivated organic compounds. (2009) (108)
- Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius. (2014) (107)
- Engineering new functions and altering existing functions. (1996) (107)
- Combinatorial protein design: strategies for screening protein libraries. (1997) (107)
- Directed evolution: Creating biocatalysts for the future (1996) (106)
- Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3. (2006) (106)
- Analysis of shuffled gene libraries. (2002) (106)
- Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes to create new catalysts. (2015) (106)
- A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases. (2017) (105)
- Template-mediated synthesis of metal-complexing polymers for molecular recognition (1991) (105)
- On the conservative nature of intragenic recombination. (2005) (104)
- Evolution favors protein mutational robustness in sufficiently large populations (2007) (104)
- Directed Evolution Library Creation (2003) (103)
- Molecular imprinting: selective materials for separations, sensors and catalysis (1995) (101)
- Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics (2019) (100)
- Structure-guided SCHEMA recombination of distantly related β-lactamases (2006) (99)
- Analytical affinity chromatography. II. Rate theory and the measurement of biological binding kinetics. (1986) (98)
- Stability and the evolvability of function in a model protein. (2004) (97)
- Modification of Galactose Oxidase to Introduce Glucose 6‐Oxidase Activity (2002) (97)
- Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination. (2010) (96)
- A General Mechanism for Network-Dosage Compensation in Gene Circuits (2010) (95)
- General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH (2013) (94)
- Alkene epoxidation catalyzed by cytochrome P450 BM-3 139-3 (2004) (92)
- Protein dynamics in a family of laboratory evolved thermophilic enzymes. (2003) (91)
- Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation (2015) (89)
- Engineering Cytochrome P450 BM3 for Terminal Alkane Hydroxylation (2006) (89)
- Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates (2010) (89)
- Multipoint binding in metal-affinity chromatography II. Effect of pH and imidazole on chromatographic retention of engineered histidine-containing cytochromes c. (1996) (88)
- Specific Protein Attachment to Artificial Membranes via Coordination to Lipid-Bound Copper(II) (1994) (86)
- An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds (2019) (85)
- Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes (2018) (85)
- Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer (2014) (84)
- Towards Materials for the Specific Recognition and Separation of Proteins (1994) (83)
- Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. (2012) (81)
- Aqueous two-phase metal affinity extraction of heme proteins (1990) (81)
- Site-directed protein recombination as a shortest-path problem. (2004) (81)
- Regioselectivity and Activity of Cytochrome P450 BM‐3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide (2002) (80)
- In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 (2008) (80)
- Directed evolution of Gloeobacter violaceus rhodopsin spectral properties. (2015) (80)
- A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases. (1999) (80)
- Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity. (2019) (79)
- Directed evolution of a far-red fluorescent rhodopsin (2014) (79)
- Global incorporation of norleucine in place of methionine in cytochrome P450 BM‐3 heme domain increases peroxygenase activity (2003) (78)
- Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate (2001) (77)
- Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization (2017) (77)
- Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme. (2017) (76)
- Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions. (2018) (75)
- The nature of chemical innovation: new enzymes by evolution* (2015) (74)
- Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase (2018) (73)
- Neutral genetic drift can aid functional protein evolution (2007) (73)
- Self-Organization, Layered Structure, and Aggregation Enhance Persistence of a Synthetic Biofilm Consortium (2011) (73)
- Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases (2009) (73)
- High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase. (2013) (73)
- Consensus protein design without phylogenetic bias. (2010) (72)
- Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography. (1995) (71)
- Colorimetric Assays for Biodegradation of Polycyclic Aromatic Hydrocarbons by Fungal Laccases (2002) (71)
- Metal-mediated protein stabilization. (1994) (70)
- Tryptophan phosphorescence study of enzyme flexibility and unfolding in laboratory-evolved thermostable esterases. (2000) (70)
- Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein. (2019) (70)
- Implications of Rewiring Bacterial Quorum Sensing (2007) (69)
- Functional and nonfunctional mutations distinguished by random recombination of homologous genes. (1997) (69)
- Characterization of His-X3-His sites in α-helices of synthetic metal-binding bovine somatotropin (1991) (69)
- Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes (2018) (69)
- A Colorimetric Assay to Quantify Dehydrogenase Activity in Crude Cell Lysates (2002) (68)
- Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity. (2011) (68)
- Discovery of a regioselectivity switch in nitrating P450s guided by MD simulations and Markov models (2016) (68)
- Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s. (2007) (68)
- Protein sequence design with deep generative models (2021) (68)
- Evolution of the C30 Carotenoid Synthase CrtM for Function in a C40 Pathway (2002) (67)
- Engineering proteins for nonnatural environments (1993) (67)
- Cu(II)‐Binding properties of a cytochrome c with a synthetic metal‐binding site: His‐X3‐His in an α‐helix (1991) (67)
- Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. (2019) (66)
- Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer (2021) (66)
- Enzymatic Primary Amination of Benzylic and Allylic C(sp3)-H Bonds. (2020) (66)
- Review: Multipoint binding and heterogeneity in immobilized metal affinity chromatography. (1995) (65)
- Analysis of affinity separations II: The characterization of affinity columns by pulse techniques (1985) (65)
- Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s. (2019) (64)
- Design by Directed Evolution. (1998) (64)
- Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues (2017) (63)
- Chemistry Takes a Bath: Reactions in Aqueous Media. (2018) (63)
- Functional Expression of Horseradish Peroxidase in E.coli by Directed Evolution (1999) (63)
- Evolution of a Pathway to Novel Long-Chain Carotenoids (2004) (61)
- Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)2 and d(CCCTGGG)2. (1987) (61)
- A mathematical model for metal affinity protein partitioning (1990) (59)
- When blind is better: Protein design by evolution (1998) (59)
- Protein Stabilization by Engineered Metal Chelation (1991) (59)
- Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. (2018) (58)
- Enzyme Engineering for Nonaqueous Solvents. II. Additive Effects of Mutations on the Stability and Activity of Subtilisin E in Polar Organic Media (1991) (58)
- Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. (2004) (58)
- Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods. (2012) (57)
- Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. (2016) (56)
- Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3. (2005) (55)
- SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. (2012) (55)
- Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3 (2009) (55)
- Engineering enzymes for noncanonical amino acid synthesis. (2018) (55)
- Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures (2014) (55)
- Analytical affinity chromatography : I. Local equilibrium theory and the measurement of association and inhibition constants (1986) (54)
- Cost-Effective Whole-Cell Assay for Laboratory Evolution of Hydroxylases in Escherichia coli (2001) (53)
- A structural study of Hypocrea jecorina Cel5A (2011) (52)
- A C35 Carotenoid Biosynthetic Pathway (2003) (52)
- Advances in machine learning for directed evolution. (2021) (52)
- Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. (2017) (52)
- Protein engineering for unusual environments. (1993) (52)
- Synthetic Bis-Metal Ion Receptors for Bis-Imidazole "Protein Analogs" (1994) (52)
- Colorimetric High-Throughput Assay for Alkene Epoxidation Catalyzed by Cytochrome P450 BM-3 Variant 139-3 (2004) (51)
- Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes. (2004) (51)
- Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability (2016) (51)
- A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons (2018) (51)
- Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase. (2016) (51)
- Improved product‐per‐glucose yields in P450‐dependent propane biotransformations using engineered Escherichia coli (2011) (50)
- Patterns of adaptation in a laboratory evolved thermophilic enzyme. (2001) (50)
- A Metal-Chelating Lipid for 2D Protein Crystallization via Coordination of Surface Histidines (1997) (49)
- Surface charge substitutions increase the stability of .alpha.-lytic protease in organic solvents (1991) (49)
- Site-selective enzymatic C‒H amidation for synthesis of diverse lactams (2019) (49)
- Engineering protein-lipid interactions : targeting of histidine-tagged proteins to metal-chelating lipid monolayers (1995) (49)
- Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy. (2016) (49)
- Comparison of Family 9 Cellulases from Mesophilic and Thermophilic Bacteria (2010) (49)
- Engineering by homologous recombination: exploring sequence and function within a conserved fold. (2007) (48)
- Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. (2016) (48)
- Directed Evolution of Vibrio fischeri LuxR for Improved Response to Butanoyl-Homoserine Lactone (2007) (47)
- Liquid chromatography plate height equations (1985) (47)
- Protein design for non-aqueous solvents. (1988) (47)
- Recent advances in engineering microbial rhodopsins for optogenetics. (2015) (47)
- Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3. (2005) (46)
- Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. (2015) (46)
- Signal Peptides Generated by Attention-Based Neural Networks. (2020) (46)
- A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. (2016) (45)
- Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. (2006) (45)
- Computationally focusing the directed evolution of proteins (2001) (44)
- Combinatorial protein design by in vitro recombination. (1998) (43)
- A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure‐guided recombination (2012) (43)
- Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo repair. (1999) (42)
- Surface Site Heterogeneity and Lateral Interactions in Multipoint Protein Adsorption (1996) (42)
- A membrane-moderated, conductimetric sensor for the detection and measurement of specific organic solutes in aqueous solutions (2000) (41)
- Informed training set design enables efficient machine learning-assisted directed protein evolution. (2021) (41)
- Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins (2017) (41)
- Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane (2012) (40)
- Synthetic biology: Engineering explored (2014) (39)
- Structure-guided SCHEMA recombination of distantly related beta-lactamases. (2006) (39)
- Non‐natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins (2014) (37)
- How proteins adapt: lessons from directed evolution. (2009) (37)
- Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima. (2018) (37)
- P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. (2014) (37)
- Enzyme engineering reaches the boiling point. (1998) (36)
- Breaking proteins with mutations: threads and thresholds in evolution (2007) (36)
- Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9 (2011) (36)
- Engineered Biosynthesis of β-Alkyl Tryptophan Analogues. (2018) (36)
- Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE (2014) (35)
- Evolutionary Design of Genetic Circuits and Cell-Cell Communications (2003) (35)
- Chimeragenesis of distantly‐related proteins by noncontiguous recombination (2013) (35)
- Engineering proteins that bind, move, make and break DNA. (2003) (35)
- Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. (2012) (34)
- Fluorescence signaling of ligand binding and assembly in metal-chelating lipid membranes. (1996) (34)
- Innovation by homologous recombination. (2013) (34)
- Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450 (2015) (34)
- Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes. (2020) (33)
- Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. (2013) (33)
- Selective Enzymatic Oxidation of Silanes to Silanols. (2020) (33)
- Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes. (2015) (32)
- Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination (2016) (31)
- SCHEMA-guided protein recombination. (2004) (31)
- Surface Grafting of Functional Polymers to Macroporous Poly(trimethylolpropane trimethacrylate) (1995) (30)
- Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities (2020) (30)
- Fancy footwork in the sequence space shuffle (2006) (30)
- Nature's Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases. (2020) (30)
- P450BM3-Axial Mutations: A Gateway to Non-Natural Reactivity (2015) (29)
- Stabilization of substilisin E in organic solvents by site‐directed mutagenesis (1992) (29)
- Strategy for the Directed Evolution of a Peptide Ligase (1996) (28)
- Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses. (2004) (28)
- Methods for in vitro DNA recombination and random chimeragenesis. (2000) (27)
- Directed Evolution of Mesophilic Enzymes into Their Thermophilic Counterparts (1999) (27)
- Combining chemistry and protein engineering for new-to-nature biocatalysis (2022) (26)
- New-to-nature chemistry from old protein machinery: carbene and nitrene transferases. (2020) (26)
- Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation. (2019) (26)
- Enantioselective Intramolecular C—H Amination Catalyzed by Engineered Cytochrome P450 Enzymes in vitro and in vivo. (2014) (25)
- Uncovering rare NADH-preferring ketol-acid reductoisomerases. (2014) (24)
- Staggered extension process (StEP) in vitro recombination. (2003) (24)
- A Dual Selection Module for Directed Evolution of Genetic Circuits (2005) (24)
- Tryptophan Synthase: Biocatalyst Extraordinaire (2020) (23)
- Metal affinity extraction of human hemoglobin in an aqueous polyethylene glycol-sodium sulfate two-phase system (1990) (23)
- Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers (2020) (23)
- Ruthenium-mediated protein cross-linking and stabilization (1993) (22)
- Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation. (2019) (22)
- A Versatile High Throughput Screen for Dioxygenase Activity Using Solid-Phase Digital Imaging (2001) (22)
- Selective recognition of bis-imidazoles by complementary bis-metal ion complexes (1993) (22)
- Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands. (2019) (22)
- Evolutionary Protein Design (2001) (22)
- Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks. (2020) (21)
- Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion (2019) (20)
- Efficient sampling of SCHEMA chimera families to identify useful sequence elements. (2013) (20)
- A Rational Approach to the Scale-up of Affinity Chromatography (1985) (18)
- Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids. (2019) (18)
- Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination. (2013) (18)
- Review: Selective ligand-exchange adsorbents prepared by template polymerization. (1995) (17)
- SUBSTRATE SELECTIVITY OF MOLECULARLY IMPRINTED POLYMERS INCORPORATING A RIGID CHELATING MONOMER, BIS-METHACRYLATO (4-METHYL, 4'-VINYL) 2,2'-BIPYRIDINE CU(II) (1996) (17)
- Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. (2015) (16)
- Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation (2021) (16)
- Chiral copper-chelate complexes alter selectivities in metal affinity protein partitioning. (1991) (16)
- Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. (2021) (15)
- Metal affinity partitioning. (1994) (15)
- Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. (2016) (15)
- Enzyme stabilization by directed evolution. (2000) (15)
- Method to protect a targeted amino acid residue during random mutagenesis. (2003) (14)
- An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes. (2021) (14)
- Thermostabilization of a Cytochrome P 450 Peroxygenase (2003) (14)
- In vivo hypermutation and continuous evolution (2022) (14)
- The Race for New Biofuels (2008) (14)
- Corrigendum: Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR (2006) (13)
- Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E (1992) (13)
- Random Field Model Reveals Structure of the Protein Recombinational Landscape (2012) (13)
- Machine Learning-Assisted Directed Evolution Navigates a Combinatorial Epistatic Fitness Landscape with Minimal Screening Burden (2020) (12)
- Enzymatic Functionalization of Carbon—Hydrogen Bonds (2011) (12)
- Enzymes by Evolution: Bringing New Chemistry to Life (2018) (12)
- Combinatorial Recombination of Gene Fragments to Construct a Library of Chimeras (2010) (12)
- Machine learning in protein engineering (2018) (11)
- Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement. (2021) (11)
- Random chimeragenesis by heteroduplex recombination. (2000) (11)
- Staggered extension process (StEP) in vitro recombination. (2002) (11)
- Enzyme Engineering by Directed Evolution (2008) (11)
- Ligand-induced reorganization and assembly in synthetic lipid membranes (1997) (11)
- Novel Metal-Affinity Protein Separations (1990) (11)
- “Itching” for new strategies in protein engineering (1999) (10)
- Microbial consortia (2015) (10)
- The Library of Maynard-Smith: My Search for Meaning in the Protein (2011) (10)
- Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin. (1991) (10)
- Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases. (2013) (10)
- High throughput screening of fungal endoglucanase activity in Escherichia coli. (2011) (10)
- Direct Enzymatic Synthesis of a Deep‐Blue Fluorescent Noncanonical Amino Acid from Azulene and Serine (2020) (10)
- Combinatorial Recombination of Gene Fragments to Construct a Library of Chimeras (2006) (10)
- Binding and two-dimensional crystallization of streptavidin at the air/water interface via engineered Cu-IDA chelator lipids (1999) (9)
- Learned protein embeddings for machine learning (2018) (9)
- Designing libraries of chimeric proteins using SCHEMA recombination and RASPP. (2014) (9)
- Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution (2009) (9)
- High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution. (2020) (9)
- Engineering a revolution (1999) (9)
- Erratum: Engineering proteins that bind, move, make and break DNA (Current Opinion in Biotechnology (August 2003) 14 (371-378) pii: S0958166903000910) (2003) (9)
- Biocatalytic Transformations of Silicon—the Other Group 14 Element (2021) (8)
- Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si-H and N-H bonds. (2021) (8)
- Artificial domain duplication replicates evolutionary history of ketol‐acid reductoisomerases (2016) (7)
- Chiral Ligand Exchange Adsorbents for Amines and Underivatized Amino Acids: 'Bait-and-Switch' Molecular Imprinting (1998) (7)
- evSeq: Cost-Effective Amplicon Sequencing of Every Variant in a Protein Library (2021) (6)
- Biocatalytic Carbene Transfer Using Diazirines. (2022) (6)
- Metal-affinity partitioning of phosphoproteins in PEG/dextran two-phase systems (1991) (6)
- Enzymatic Nitrogen Insertion into Unactivated C-H Bonds. (2022) (6)
- Unnatural Selection: Molecular Sex for Fun and Profit (1999) (5)
- Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis (2019) (5)
- Retraction (2020) (4)
- Directed evolution of protein-based neurotransmitter sensors for MRI. (2013) (4)
- Chemistry and biotechnology: a productive union meets new challenges (2003) (4)
- Synthetic Biology Approaches for Organic Synthesis (2014) (4)
- Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design. (2018) (4)
- Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution (2003) (4)
- Noncontiguous SCHEMA protein recombination. (2014) (4)
- Inferring interactions from an alignment of folded and unfolded protein sequences (2005) (4)
- Reversal of NAD(P)H cofactor dependence by protein engineering. (2012) (4)
- Protein Engineering by Structure‐Guided SCHEMA Recombination (2011) (4)
- Exploring the Diversity of Heme Enzymes through Directed Evolution (2003) (3)
- Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides (2021) (3)
- Nuclear magnetic relaxation study of hindered rotational diffusion in gels (1989) (3)
- Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues. (2018) (3)
- Inside Cover: Directed Evolution: Bringing New Chemistry to Life (Angew. Chem. Int. Ed. 16/2018) (2018) (3)
- Directed Evolution of Artificial Metalloenzymes: Bridging Synthetic Chemistry and Biology (2018) (3)
- Directed Evolution of an Allosteric Tryptophan Synthase to Create a Platform for Synthesis of Noncanonical Amino Acids (2017) (3)
- Recombinant Protein Stabilization through Engineered Metal-Chelating Sites (1993) (3)
- Stereoselective Hydroxylation of an Achiral Cyclopentanecarboxylic Acid Derivative Using Engineered P450s BM‐3. (2005) (3)
- Nobel Prizes 2018. (2018) (2)
- New enzymes for organic synthesis : screening, supply and engineering (1997) (2)
- Inside Back Cover: High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase (Angew. Chem. Int. Ed. 21/2013) (2013) (2)
- New Additions to the Arsenal of Biocatalysts for Noncanonical Amino Acid Synthesis. (2022) (2)
- Erratum to "Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius" (Metab. Eng. 24C (2014) 1-8) (2014) (2)
- Engineering enzymes for nonnatural environments: Improved biocatalysts for the chemical and biotechnology industries (1993) (2)
- Electron transfer in cytochromes C with chelated ruthenium(II) polypyridine complexes. (1993) (2)
- Advances in protein chemistry. Introduction. (2000) (2)
- Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases (2023) (2)
- Enzymes, Directed Evolution (2002) (1)
- MicroED Structure of a Protoglobin Reactive Carbene Intermediate (2022) (1)
- Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius (2014) (1)
- ormation of Indigo by Recombinant Mammalian ytochrome P 4501 (1999) (1)
- Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. (2021) (1)
- Engineering Nonaqueous Solvent-Compatible Enzymes (1993) (1)
- Biocatalyzed α-Hydroxylation of Phenyl-acetic Acid Derivatives and Buspirone (2006) (1)
- Functional expression of horseradish peroxidase in bacteria through directed evolution (1999) (1)
- Corrigendum: A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments (2007) (1)
- Innenrücktitelbild: High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase (Angew. Chem. 21/2013) (2013) (1)
- Titelbild: Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. 26/2014) (2014) (1)
- NMR Studies of Crambin Structure and Unfolding in Nonaqueous Solvents a (1988) (1)
- Binding and Two‐Dimensional Crystallization of Streptavidin at the Air/Water Interface via Engineered Cu‐IDA Chelator Lipids (1999) (1)
- On the conservative nature of intragenic (2005) (1)
- The Library of Maynard-Smith (2012) (1)
- Inferring interactions from combinatorial protein libraries (2005) (1)
- Engineering proteins that bind, move, make and break DNA. (2003) (0)
- Enzyme catalysts for a biotechnology-based chemical industry. Quarterly progress report, September 29--December 28, 1997 (1998) (0)
- Metalloprotein-based contrast sensors for neurochemical detection by MRI (2012) (0)
- The week in science: 20–26 May 2016 (2016) (0)
- cytochrome P450 BM3h-8C8 MRI sensor bound to dopamine (2012) (0)
- THERMOPHYLIC PNB ESTERASE (1999) (0)
- Production de genes et de proteines hybrides fonctionnels (2000) (0)
- Directed Evolution of Novel Enzyme Activities (2002) (0)
- Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization (2018) (0)
- Engineering Enzymes for New‐to‐Nature Carbene Chemistry (2021) (0)
- Chimeric Family 1 beta-glucosidase made with non-contiguous SCHEMA (2013) (0)
- Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 (2018) (0)
- High-resolution structure of TxtE with bound tryptophan substrate (2014) (0)
- Faculty Opinions recommendation of Protein model refinement using an optimized physics-based all-atom force field. (2008) (0)
- Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB (2021) (0)
- Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate (2018) (0)
- Crystal structure of ketol-acid reductoisomerase from Azotobacter (2015) (0)
- Advances in directed protein evolution (2019) (0)
- Enzymatic Enzymatic Synthesis Synthesis (2006) (0)
- High Resolution Models from Low Resolution Data: Recombination of Fragments for Crystallographic Structure Determination (2012) (0)
- Engineered microorganisms capable of converting pyruvate to isobutanol under anaerobic conditions (2009) (0)
- SCHEMARecombinationofa FungalCellulaseUncoversa SingleMutationThatContributes (2009) (0)
- Machine-learning-guided directed evolution for protein engineering (2019) (0)
- Structure of CYP119 with T213A and C317H mutations (2016) (0)
- The structure of the Slackia exigua KARI in complex with NADP (2013) (0)
- Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound (2016) (0)
- Computationally-guided directed evolution (2000) (0)
- Elastomeric Microfabricated Fluorescence-Activated Cell Sorters ( μ FACS ) (2002) (0)
- Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD (2015) (0)
- Author ' s personal copy Innovation by homologous recombination (2013) (0)
- Conception evolutive a ciblage informatique (2002) (0)
- Cellular synthesis of non-linear proteins (2013) (0)
- Expression and Directed Evolution of Peroxidase Enzymes (2000) (0)
- Evolution by Structure-Based Protein Recombination (2003) (0)
- New enzymes for green chemistry (2017) (0)
- Design and Construction of Synthetic Metal-Binding Proteins (1989) (0)
- Structure of NADH-preferring ketol-acid reductoisomerase from an uncultured archean (2015) (0)
- Cytochrome P411BM3-CIS cyclopropanation catalyst (2013) (0)
- X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A (2015) (0)
- EngineeringCytochrome P450s for EnantioselectiveCyclopropenation of Internal Alkynes (2020) (0)
- Structure and Function in Nucleic Acids: Mutagenesis (1987) (0)
- Cover Picture: Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. Int. Ed. 26/2014) (2014) (0)
- Enzyme catalysts for a biotechnology-based chemical industry. Quarterly progress report, January 1--April 1, 1998 (1998) (0)
- Crystal Structure of Lactococcus lactis Alcohol Dehydrogenase variant RE1 (2012) (0)
- Stereodivergent cyclopropanation of unactivated alkenes with heme proteins (2017) (0)
- Enzyme catalysts for a biotechnology-based chemical industry. Final report, September 29, 1993--September 28, 1998 (1998) (0)
- Engineered Cytochrome c from Rhodothermus marinus, Rma TDE (2018) (0)
- Rhodopsin Engineering through Structure-Guided Recombination (2016) (0)
- Symposium on Metal-Mediated Molecular Architectures. (1995) (0)
- Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor (2013) (0)
- Crystal Structure of Cel5A (EG2) from Hypocrea jecorina (Trichoderma reesei) (2011) (0)
- Engineered TrpB biocatalysts for the synthesis of tryptophan analogs (2017) (0)
- Photo-initiated and electron transfer reactivity of ruthenium-labeled cytochrome P450 (2014) (0)
- Engineered carbene transferase RmaNOD Q52V, putative nitric oxide dioxygenase from Rhodothermus marinus (2020) (0)
- B M ] 2 8 Ja n 20 04 Stability and the Evolvability of Function in a Model Protein Running Title : Evolving Stability and Function (2008) (0)
- Enzyme-Catalyzed Site-Selective C–H Amidation (2020) (0)
- Directed evolution – bringing the power of evolution to the laboratory : 2018 (2018) (0)
- Faculty Opinions recommendation of An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. (2009) (0)
- Computational Thermostable Cellulase Engineering for Enhanced Biofuel Production (2012) (0)
- Biocatalysis Directed Evolution : Bringing New Chemistry to Life (2017) (0)
- Apo structure of KARI from Ignisphaera aggregans (2015) (0)
- Spotlights on our sister journals: ChemBioChem 18/2016 (2016) (0)
- Enzyme catalysts for a biotechnology-based chemical industry. Quarterly progress report, April 1--July 1, 1998 (1998) (0)
- E. coli lactaldehyde reductase (FucO) M185C mutant (2015) (0)
- Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in the active site (2016) (0)
- Faculty Opinions recommendation of High-level production of porphyrins in metabolically engineered Escherichia coli: systematic extension of a pathway assembled from overexpressed genes involved in heme biosynthesis. (2003) (0)
- TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine (2015) (0)
- Crystal Structure of Lactococcus lactis Alcohol Dehydrogenase (2012) (0)
- Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors (2019) (0)
- Structural and Kinetic Studies of Novel Cytochrome P450 Small-Alkane Hydroxylases (2012) (0)
- Metal Affinity Partitioning of Phosphoproteins in Aqueous Two-Phase Systems (1992) (0)
- Crystal structure of a fungal chimeric cellobiohydrolase Cel6A (2013) (0)
- Faculty Opinions recommendation of Genome shuffling of Lactobacillus for improved acid tolerance. (2002) (0)
- Thesis Title: Engineering Galactose Oxidase to Increase Expression Levels in E. coli, Enhance Thermostability and Introduce Novel Activities (2011) (0)
- P411BM3-CIS T438S I263F regioselective C-H amination catalyst (2014) (0)
- cytochrome P450 BM3h-2G9C6 MRI sensor bound to serotonin (2012) (0)
- High-resolution structure of TxtE in the absence of substrate (2014) (0)
- Faculty Opinions recommendation of Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. (2009) (0)
- Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates (2023) (0)
- Faculty Opinions recommendation of Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. (2008) (0)
- A process for the preparation of polynucleotide and polypeptide sequences (1998) (0)
- Faculty Opinions recommendation of Improving the catalytic activity of Candida antarctica lipase B by circular permutation. (2006) (0)
- S41 Psychrophilic Protease (2007) (0)
- Cytochrome P450BM3-CIS cyclopropanation catalyst (2013) (0)
- Metal Organic Frameworks (2020) (0)
- Expanding the enzyme universe through a marriage of chemistry and evolution (2014) (0)
- Holo structure of ketol-acid reductoisomerase from Ignisphaera aggregans (2015) (0)
- Crystal structure of the 5-selective H176F mutant of Cytochrome TxtE (2016) (0)
- Cytochrome P411 P-4 A82L A78V F263L amination catalyst (2017) (0)
- cytochrome P450 BM3h-2G9C6 MRI sensor, no ligand (2012) (0)
- Enzyme Design for Nonaqueous Solvents (2021) (0)
- Holo TrpB from Pyrococcus furiosus (2016) (0)
- Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site (2015) (0)
- Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine (2018) (0)
- Faculty Opinions recommendation of Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. (2003) (0)
- Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted Cyclopropanes by Carbene Transfer. (2022) (0)
- Synthetic Cis Regulatory Modules (0)
- Enantioselective C-H amination via directed evolution of cytochrome P450 enzymes (2020) (0)
- Surfactants in droplet-based microfluidics (2022) (0)
- Cytochrome P450‐Catalyzed Insertion of Carbenoids into N—H Bonds. (2014) (0)
- Engineered Cytochrome c from Rhodothermus marinus (Rma TDE) bound to carbene intermediate (1-ethoxy-1-oxopropan-2-ylidene) (2018) (0)
- Recombinaison de sequences de polynucleotides a l'aide de sequences d'amorces aleatoires ou definies (1998) (0)
- ABLC Forum: Aspirations for a Fragile Planet (2021) (0)
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