James Collins | Academic Influence

Why Is James Collins Influential?

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According to Wikipedia, James J. Collins is an American bioengineer, and the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT. He is one of the founders of the emerging field of synthetic biology, and has made multiple synthetic biology breakthroughs in biotechnology and biomedicine, including paper-based diagnostics for Zika & Ebola and programmable cells that serve as living diagnostics and living therapeutics to detect-and-treat infections, rare genetic metabolic disorders, and inflammatory bowel disease. Collins is also a pioneering researcher in systems biology, having made fundamental discoveries regarding the actions of antibiotics and the emergence of antibiotic resistance.

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James Collins 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

Construction of a genetic toggle switch in Escherichia coli (2000) (3961)
A practical method for calculating largest Lyapunov exponents from small data sets (1993) (2875)
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. (2010) (2510)
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics (2007) (2293)
Stochasticity in gene expression: from theories to phenotypes (2005) (2257)
How antibiotics kill bacteria: from targets to networks (2010) (1706)
Noise in eukaryotic gene expression (2003) (1599)
Nucleic acid detection with CRISPR-Cas13a/C2c2 (2017) (1522)
Large-Scale Mapping and Validation of Escherichia coli Transcriptional Regulation from a Compendium of Expression Profiles (2007) (1499)
Wisdom of crowds for robust gene network inference (2012) (1457)
The Immunological Genome Project: networks of gene expression in immune cells (2008) (1376)
Synthetic biology: applications come of age (2010) (1199)
Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling (2003) (1182)
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6 (2018) (1093)
Highly-efficient Cas9-mediated transcriptional programming (2014) (1025)
Open-loop and closed-loop control of posture: A random-walk analysis of center-of-pressure trajectories (2004) (1010)
Cellular Decision Making and Biological Noise: From Microbes to Mammals (2011) (934)
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components (2016) (823)
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. (2010) (774)
Metabolite-Enabled Eradication of Bacterial Persisters by Aminoglycosides (2011) (723)
Engineered gene circuits (2002) (722)
A Deep Learning Approach to Antibiotic Discovery (2020) (713)
Dispersing biofilms with engineered enzymatic bacteriophage (2007) (710)
Stochastic resonance without tuning (1995) (709)
Reverse engineering gene networks using singular value decomposition and robust regression (2002) (692)
Computational studies of gene regulatory networks: in numero molecular biology (2001) (624)
Noise-based switches and amplifiers for gene expression. (2000) (620)
Programmable cells: interfacing natural and engineered gene networks. (2004) (610)
A brief history of synthetic biology (2014) (607)
Phenotypic consequences of promoter-mediated transcriptional noise. (2006) (605)
Biomechanical gait alterations independent of speed in the healthy elderly: evidence for specific limiting impairments. (1998) (604)
Antibiotics induce redox-related physiological alterations as part of their lethality. (2014) (592)
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip (2015) (586)
Synthetic Gene Networks That Count (2009) (560)
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells (2011) (559)
Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria (2013) (549)
Aging, muscle activity, and balance control: physiologic changes associated with balance impairment. (2003) (541)
Vibrating insoles and balance control in elderly people (2003) (534)
Engineered riboregulators enable post-transcriptional control of gene expression (2004) (528)
Bacterial charity work leads to population-wide resistance (2010) (528)
Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014) (527)
Definitions and guidelines for research on antibiotic persistence (2019) (522)
Next-Generation Machine Learning for Biological Networks (2018) (515)
Coupled nonlinear oscillators and the symmetries of animal gaits (1993) (490)
Antibiotics and the gut microbiota. (2014) (473)
Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death (2008) (472)
Prediction and measurement of an autoregulatory genetic module (2003) (470)
DIVERSITY-BASED, MODEL-GUIDED CONSTRUCTION OF SYNTHETIC GENE NETWORKS WITH PREDICTED FUNCTIONS (2009) (468)
Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling (2003) (464)
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy (2009) (460)
Paper-Based Synthetic Gene Networks (2014) (451)
A community effort to assess and improve drug sensitivity prediction algorithms (2014) (448)
CellNet: Network Biology Applied to Stem Cell Engineering (2014) (440)
Antibiotic Treatment Expands the Resistance Reservoir and Ecological Network of the Phage Metagenome (2013) (439)
Antibiotic efficacy is linked to bacterial cellular respiration. (2015) (438)
Noise-enhanced tactile sensation (1996) (420)
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli (2007) (414)
MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium (2009) (409)
Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks (2005) (392)
Microbial persistence and the road to drug resistance. (2013) (390)
Syntrophic exchange in synthetic microbial communities (2014) (385)
Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics (2012) (384)
Reconstruction expansion as a geometry-based framework for choosing proper delay times (1994) (383)
Signaling-Mediated Bacterial Persister Formation (2011) (369)
Role of reactive oxygen species in antibiotic action and resistance. (2009) (369)
Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells (2013) (369)
Noise-enhanced information transmission in rat SA1 cutaneous mechanoreceptors via aperiodic stochastic resonance. (1996) (360)
Synthetic Biology Moving into the Clinic (2011) (360)
Symmetry in locomotor central pattern generators and animal gaits (1999) (358)
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses (2018) (350)
Next-Generation Synthetic Gene Networks (2009) (348)
RNA synthetic biology (2006) (348)
A bottom-up approach to gene regulation (2006) (346)
Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro (2014) (337)
Noise‐enhanced balance control in patients with diabetes and patients with stroke (2006) (330)
Deconstructing transcriptional heterogeneity in pluripotent stem cells (2014) (327)
Noise-enhanced human balance control. (2002) (323)
Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production (2012) (322)
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (2012) (318)
Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage. (2015) (310)
Reduced hip extension during walking: healthy elderly and fallers versus young adults. (2001) (310)
A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012) (305)
Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. (2012) (304)
Noise in human muscle spindles (1996) (297)
Programmable bacteria detect and record an environmental signal in the mammalian gut (2014) (293)
Synchronizing genetic relaxation oscillators by intercell signaling (2002) (292)
Age-related changes in open-loop and closed-loop postural control mechanisms (2004) (292)
The effects of visual input on open-loop and closed-loop postural control mechanisms (2004) (290)
Reprogramming of T cells from human peripheral blood. (2010) (284)
Designer gene networks: Towards fundamental cellular control. (2001) (278)
A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells (2007) (277)
Cas9 gRNA engineering for genome editing, activation and repression (2015) (253)
Effects of Colored Noise on Stochastic Resonance in Sensory Neurons (1999) (247)
Complex cellular logic computation using ribocomputing devices (2017) (244)
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. (2013) (239)
Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development (2010) (238)
An enhanced CRISPR repressor for targeted mammalian gene regulation (2018) (237)
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. (2016) (236)
Synthetic biology devices for in vitro and in vivo diagnostics (2015) (234)
Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet (2014) (234)
Comparative Analysis of Cas9 Activators Across Multiple Species (2016) (231)
Portable, On-Demand Biomolecular Manufacturing (2016) (230)
The redundant nature of locomotor optimization laws. (1995) (227)
A modular network for legged locomotion (1998) (226)
Integrating Biological Redesign: Where Synthetic Biology Came From and Where It Needs to Go (2014) (222)
Combinatorial promoter design for engineering noisy gene expression (2007) (219)
The engineering of gene regulatory networks. (2003) (211)
Hard-wired central pattern generators for quadrupedal locomotion (1994) (210)
Unraveling the physiological complexities of antibiotic lethality. (2015) (207)
Synthetic gene network for entraining and amplifying cellular oscillations. (2002) (205)
“Deadman” and “Passcode” microbial kill switches for bacterial containment (2015) (204)
Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control. (2017) (196)
Age-related changes in the initiation of gait: degradation of central mechanisms for momentum generation. (1998) (195)
Noise-mediated enhancements and decrements in human tactile sensation (1997) (190)
Noise-enhanced balance control in older adults (2002) (184)
Adult somatic stem cells in the human parasite, Schistosoma mansoni (2013) (183)
Heterogeneous bacterial persisters and engineering approaches to eliminate them. (2011) (182)
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators (2010) (180)
Tunable protein degradation in bacteria (2014) (177)
DYNAMIC CONTROL OF CARDIAC ALTERNANS (1997) (177)
Bacterial Metabolism and Antibiotic Efficacy (2017) (176)
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. (2009) (176)
The transcriptional landscape of hematopoietic stem cell ontogeny. (2012) (175)
Designing microbial consortia with defined social interactions (2018) (174)
The Role of the Quadriceps in Controlling Impulsive Forces around Heel Strike (1990) (169)
Noise-enhanced vibrotactile sensitivity in older adults, patients with stroke, and patients with diabetic neuropathy. (2002) (167)
Noise-enhanced human sensorimotor function (2003) (165)
A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action (2019) (164)
Upright, correlated random walks: A statistical-biomechanics approach to the human postural control system. (1995) (162)
A multiply redundant genetic switch ‘ locks in ’ the transcriptional signature of regulatory T cells (2012) (160)
Programmable CRISPR-responsive smart materials (2019) (160)
A network biology approach to prostate cancer (2007) (159)
Genetic switchboard for synthetic biology applications (2012) (159)
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma (2016) (158)
Comparison of Cas9 activators in multiple species (2016) (158)
Tunable Signal Processing in Synthetic MAP Kinase Cascades (2011) (155)
A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers (2018) (150)
Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells (2015) (149)
The measurement and analysis of age-related changes in Caenorhabditis elegans. (2008) (147)
Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance (2013) (143)
Tuning and controlling gene expression noise in synthetic gene networks (2010) (141)
CRISPR-based diagnostics. (2021) (140)
Impulsive forces during walking and their clinical implications. (1989) (138)
Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function. (2017) (138)
Wearable materials with embedded synthetic biology sensors for biomolecule detection. (2021) (131)
Fungicidal drugs induce a common oxidative-damage cellular death pathway. (2013) (130)
Microbial environments confound antibiotic efficacy. (2011) (130)
Nucleic acid detection with CRISPR-Cas 13 a / C 2 c 2 Citation (2017) (130)
Hexapodal gaits and coupled nonlinear oscillator models (1993) (128)
Using electrical noise to enhance the ability of humans to detect subthreshold mechanical cutaneous stimuli. (1998) (127)
Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation (2014) (126)
Probiotic strains detect and suppress cholera in mice (2018) (121)
Noise shaping in populations of coupled model neurons. (1999) (118)
An Atlas for Schistosoma mansoni Organs and Life-Cycle Stages Using Cell Type-Specific Markers and Confocal Microscopy (2011) (117)
Targeting Antibiotic Tolerance, Pathogen by Pathogen (2018) (115)
Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate (2019) (113)
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans (2006) (111)
Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni (2013) (110)
Cell-free biosensors for rapid detection of water contaminants (2020) (109)
Next-generation biocontainment systems for engineered organisms (2018) (107)
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. (2012) (106)
A CRISPR Cas9-based gene drive platform for genetic interaction analysis in Candida albicans (2017) (105)
Enhancing tactile sensation in older adults with electrical noise stimulation (2002) (103)
A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells (2012) (102)
Functional characterization of bacterial sRNAs using a network biology approach (2011) (101)
The effects of stochastic galvanic vestibular stimulation on human postural sway (1999) (98)
Chromatin regulation at the frontier of synthetic biology (2015) (96)
Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants (2021) (95)
Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. (2014) (95)
Iterative plug-and-play methodology for constructing and modifying synthetic gene networks (2012) (93)
Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes (2012) (93)
Roles for the transcription elongation factor NusA in both DNA repair and damage tolerance pathways in Escherichia coli (2010) (90)
Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells (2013) (90)
Biophysical Constraints Arising from Compositional Context in Synthetic Gene Networks. (2017) (90)
Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics. (2017) (89)
Stochastic Resonance in Ensembles of Nondynamical Elements: The Role of Internal Noise (1997) (88)
Evidence that coronavirus superspreading is fat-tailed (2020) (88)
Clinically relevant mutations in core metabolic genes confer antibiotic resistance (2021) (87)
A network biology approach to aging in yeast (2009) (85)
Synchronization of noisy systems by stochastic signals. (1999) (85)
Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies (2019) (85)
BioBits™ Explorer: A modular synthetic biology education kit (2018) (83)
A group-theoretic approach to rings of coupled biological oscillators (1994) (80)
Kinetic alterations independent of walking speed in elderly fallers. (2000) (80)
Muscle-Ligament Interactions at the Knee during Walking (1991) (79)
Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria (2020) (78)
Human Balance out of Equilibrium: Nonequilibrium Statistical Mechanics in Posture Control (1998) (78)
Chemogenomics and orthology‐based design of antibiotic combination therapies (2016) (77)
Enhancing human balance control with galvanic vestibular stimulation (2001) (72)
Reconstruction of complex single-cell trajectories using CellRouter (2018) (71)
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms (2018) (71)
Robust Identification of Large Genetic Networks (2003) (70)
A role for the bacterial GATC methylome in antibiotic stress survival (2016) (69)
Predicting the dynamic postural control response from quiet-stance behavior in elderly adults. (2003) (69)
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR/Cas9 in yeast (2018) (68)
Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies. (2015) (67)
A Deep Learning Approach to Antibiotic Discovery (2020) (66)
Move over ZFNs (2011) (66)
Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice (2014) (66)
Understanding Biological Regulation Through Synthetic Biology. (2018) (66)
BioBits™ Bright: A fluorescent synthetic biology education kit (2018) (65)
Antibiotic efficacy-context matters. (2017) (64)
Creating Single-Copy Genetic Circuits. (2016) (62)
De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic (2019) (59)
Symmetry-breaking bifurcation: A possible mechanism for 2:1 frequency-locking in animal locomotion (1992) (58)
Coherence resonance in excitable and oscillatory systems: the essential role of slow and fast dynamics. (1999) (58)
A Blueprint for a Synthetic Genetic Feedback Controller to Reprogram Cell Fate. (2017) (57)
A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding (2020) (56)
Translating the noise (2002) (56)
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. (2014) (55)
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection (2020) (54)
Antioxidant Strategies to Tolerate Antibiotics (2011) (54)
Balancing act [noise based sensory enhancement technology] (2005) (54)
Mechanism of stochastic resonance enhancement in neuronal models driven by 1/f noise. (1999) (53)
Suppressing arrhythmias in cardiac models using overdrive pacing and calcium channel blockers. (2002) (52)
Posttranscriptional control of Klebsiella pneumoniae nif mRNA stability by the nifL product (1986) (52)
Central role for RNase YbeY in Hfq-dependent and Hfq-independent small-RNA regulation in bacteria (2014) (51)
Drinking and Crime (1982) (50)
Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni (2018) (50)
Publisher Correction: Definitions and guidelines for research on antibiotic persistence (2019) (50)
A deep learning approach to programmable RNA switches (2020) (49)
Predictive biology: modelling, understanding and harnessing microbial complexity (2020) (49)
A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite (2013) (48)
Whole mount in situ hybridization methodology for Schistosoma mansoni. (2011) (47)
Differential splicing across immune system lineages (2013) (47)
Engineering living therapeutics with synthetic biology. (2021) (47)
Synthetic Biology: Bits and pieces come to life (2012) (46)
A theory for controlling cell cycle dynamics using a reversibly binding inhibitor. (1998) (46)
Identification of new markers for the Schistosoma mansoni vitelline lineage☆ (2016) (46)
Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. (2017) (46)
DNA sense-and-respond protein modules for mammalian cells (2015) (44)
Boosting bacterial metabolism to combat antibiotic resistance. (2015) (44)
Evolving complex dynamics in electronic models of genetic networks. (2004) (44)
Regulation of Physiologic Actions of LRRK2: Focus on Autophagy (2011) (43)
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images (2021) (42)
Synthetic biology platform technologies for antimicrobial applications. (2016) (41)
Size matters: network inference tackles the genome scale (2007) (41)
The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan (2008) (40)
Stem cell progeny contribute to the schistosome host-parasite interface (2016) (40)
RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming. (2016) (39)
It's No Fluke: The Planarian as a Model for Understanding Schistosomes (2013) (39)
Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy aging. (2001) (38)
Platyhelminthes (2017) (38)
Genomic approaches to deconstruct pluripotency. (2011) (38)
Protein interactions: Unspinning the web (2001) (38)
Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni (2018) (37)
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types (2018) (37)
Deep learning identifies synergistic drug combinations for treating COVID-19 (2021) (37)
Assessing muscle stiffness from quiet stance in Parkinson's disease (1999) (36)
Home care for the dying child. A parent's perception. (1998) (36)
Role of the spoT gene product and manganese ion in the metabolism of guanosine 5'-diphosphate 3'-diphosphate in Escherichia coli. (1979) (35)
Enhancing aperiodic stochastic resonance through noise modulation. (1998) (35)
Influence of gait parameters on the loading of the lower limb. (1989) (35)
Using Engineered Bacteria to Characterize Infection Dynamics and Antibiotic Effects In Vivo. (2017) (34)
The effects of spaceflight on open-loop and closed-loop postural control mechanisms: human neurovestibular studies on SLS-2 (2004) (34)
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors (2017) (34)
Engineering advanced logic and distributed computing in human CAR immune cells (2021) (33)
Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni (2020) (32)
Introduction to focus issue: quantitative approaches to genetic networks. (2013) (30)
Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics (2021) (30)
Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility (2019) (29)
Using weak impulses to suppress traveling waves in excitable media. (1999) (29)
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics. (2020) (29)
Biophysics: Fishing for function in noise (1999) (29)
ENCODING CHAOS IN NEURAL SPIKE TRAINS (1998) (28)
CONTROLLED MOVEMENT AND SUPPRESSION OF SPIRAL WAVES IN EXCITABLE MEDIA (1998) (28)
Systems Biology Strikes Gold (2009) (28)
Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality (2017) (28)
The effects of stochastic monopolar galvanic vestibular stimulation on human postural sway. (2002) (28)
Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo (2016) (28)
The dynamics of quasi-static posture control (1999) (27)
Control of Klebsiella pneumoniae nif mRNA synthesis (1985) (27)
Gene regulation: Neutralizing noise in gene networks (2000) (26)
Schistosomiasis as a disease of stem cells (2016) (26)
Synthetic biology: How best to build a cell. (2014) (26)
REAL-TIME EXPERIMENTAL CONTROL OF A SYSTEM IN ITS CHAOTIC AND NONCHAOTIC REGIMES (1997) (25)
Repression of nitrogen fixation in Klebsiella pneumoniae at high temperature (1984) (25)
A pathway and genetic factors contributing to elevated gene expression noise in stationary phase. (2007) (24)
Real-time, adaptive, model-independent control of low-dimensional chaotic and nonchaotic dynamical systems (1997) (24)
MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni (2017) (24)
A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria (2019) (23)
Precise Cas9 targeting enables genomic mutation prevention (2016) (23)
Insulating gene circuits from context by RNA processing (2012) (22)
Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality (2021) (22)
The distribution of genomic variations in human iPSCs is related to replication-timing reorganization during reprogramming. (2014) (22)
Signal Processing in Single Cells (2005) (22)
Deep-Learning Resources for Studying Glycan-Mediated Host-Microbe Interactions. (2020) (22)
Rapid, Low-Cost Detection of Water Contaminants Using Regulated In Vitro Transcription (2019) (21)
Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing (2019) (21)
Control of chaos in excitable physiological systems: A geometric analysis. (1997) (20)
Transient growth inhibition of Escherichia coli K-12 by ion chelators: "in vivo" inhibition of ribonucleic acid synthesis (1979) (20)
It's a small world (2015) (20)
Networking Opportunities for Bacteria (2008) (20)
Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency (2014) (19)
Visualizing the effects of filtering chaotic signals (1994) (18)
Creating CRISPR-responsive smart materials for diagnostics and programmable cargo release (2020) (17)
Rewiring Bacteria, Two Components at a Time (2008) (16)
NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea (2016) (16)
Antagonistic-synergistic muscle action at the knee during competitive weightlifting (1994) (15)
A lophotrochozoan-specific nuclear hormone receptor is required for reproductive system development in the planarian. (2014) (14)
Tryptophan hydroxylase Is Required for Eye Melanogenesis in the Planarian Schmidtea mediterranea (2015) (14)
A systems biology pipeline identifies regulatory networks for stem cell engineering (2019) (14)
Point-of-Care Devices to Detect Zika and Other Emerging Viruses. (2020) (14)
Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea* (2016) (14)
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis. (2022) (13)
Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond. (2021) (13)
RNA-responsive elements for eukaryotic translational control. (2021) (13)
Targeted erythropoietin selectively stimulates red blood cell expansion in vivo (2016) (12)
Molecular genetic analysis of AvrRpt2 activity in promoting virulence of Pseudomonas syringae. (2005) (12)
Frequency Control of an Oscillatory Reaction by Reversible Binding of an Autocatalyst (1999) (12)
Plug-and-play with RNA (2005) (12)
Resource Paper-Based Synthetic Gene Networks (2014) (12)
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy (2013) (12)
Systems biology makes it personal. (2009) (10)
A male-derived nonribosomal peptide pheromone controls female schistosome development (2022) (10)
Tuning stochastic resonance (1995) (10)
A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding (2020) (10)
Using Natural Language Processing to Learn the Grammar of Glycans (2020) (10)
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma (2022) (9)
Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway (2020) (9)
Gene regulation: hacking the network on a sugar high. (2008) (9)
SchistoCyte Atlas: A Single-Cell Transcriptome Resource for Adult Schistosomes. (2021) (9)
Alternative Splicing of MBD 2 Supports Self-Renewal in Human Pluripotent Stem Cells (2014) (9)
Noise-Enhanced Human Sensorimotor Function Using Stochastic Resonance to Enhance Somatosensation and Improve Performance of the Human Balance Control System (2003) (9)
Editorial–Synthetic Biology (2010) (8)
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality. (2021) (8)
The dying child (2003) (8)
Advances in parenteral injection devices and aids (2016) (8)
Dioxin exposure. (1993) (8)
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples (2022) (7)
The Effect of Compositional Context on Synthetic Gene Networks (2016) (7)
Molecular biology. Signal processing in single cells. (2005) (7)
Anomalous COVID-19 tests hinder researchers (2021) (7)
Stochastic regulation of gene expression (2000) (7)
De-Novo-Designed Translational Repressors for Multi-Input Cellular Logic (2018) (6)
Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni (2020) (6)
Defining cellular identity through network biology (2014) (6)
Stress/Burnout Report. (1980) (6)
Random Walking during Quiet Standing 1 (6)
Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies (2022) (6)
SweetOrigins: Extracting Evolutionary Information from Glycans (2020) (6)
A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host (2018) (6)
And the Noise Played on: Stochastic Gene Expression and HIV-1 Infection (2005) (5)
Methods for Studying the Germline of the Human Parasite Schistosoma mansoni. (2017) (5)
Deep Learning for RNA Synthetic Biology (2019) (5)
Abstract 4920: Gene network models identify targets for mammary tumor normalization (2012) (5)
Enhancing Human Balance Control by Apply Random Vibrations to the Ankle Tendons: 2392 (2006) (5)
Benchmarking AlphaFold‐enabled molecular docking predictions for antibiotic discovery (2022) (5)
Oligonucleotide Array CGH Analysis of a Robust Whole Genome Amplification Method (2007) (5)
Vibrating Insoles Improve Balance in Diabetic Patients with Peripheral Neuropathy (2004) (4)
Erratum: Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells (Nature Biotechnology (2011) 29 (1117-1119)) (2012) (4)
Controlling Neuronal Noise Using Chaos Control (1995) (4)
CRISPR Guide RNA Cloning for Mammalian Systems. (2018) (4)
Federal Drug Data for National Policy. (1990) (4)
Making a noisy gene: HDACs turn up the static. (2012) (3)
Cellular signal processing: out of one, many. (2012) (3)
Corrigendum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (2012) (3)
Postural control mechanisms in normal and toe-standing (2001) (3)
Simultaneous detection of SARS-CoV-2 RNA and host antibodies enabled by a multiplexed electrochemical sensor platform (2021) (3)
Colonization with heterologous bacteria reprograms a Caenorhabditis elegans nutritional phenotype (2020) (3)
Editorial overview: Antimicrobials: grappling with the complexities of antibiotics and resistance. (2014) (3)
Analysis of Schistosoma mansoni Extracellular Vesicles Surface Glycans Reveals Potential Immune Evasion Mechanism and New Insights on Their Origins of Biogenesis (2021) (3)
Correction: Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development (2015) (3)
Inferring Microbial Genetic Networks Statistical learning applied to transcript responses help to gauge how genes influence one another and to identify complex networks (2004) (3)
Bacteria as control engineers. (2011) (2)
Engineering microbial peer pressure (2019) (2)
Tactile stimulation of insoles and balance control in elderly people (2004) (2)
Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function (2020) (2)
miR-34a as a novel regulator of TGFβ signaling in GBM (2012) (2)
Chapter 6 Controlling cardiac arrhythmias: The relevance of nonlinear dynamics (2001) (2)
Journal club (2009) (2)
A Nonlinear Dynamical Analysis Of The Human Postural Control System (1991) (2)
High-throughput creation and functional profiling of eukaryotic DNA sequence variant libraries using CRISPR/Cas9 (2017) (2)
A Systems Biology Approach to Study the Acquisition of Adult Repopulating Potential During Hematopoietic Stem Cell Ontogeny. (2009) (2)
BONE MARROW-ON-A-CHIP (2012) (2)
Overcoming Antibiotic Resistance. (2019) (2)
2016 Annual Report - Argonne Leadership Computing Facility (2016) (2)
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development (2022) (2)
Engineering synthetic bacteriophage to combat antibiotic-resistant bacteria (2009) (2)
Reply to Blair et al.: Dose-dependent effects and oxidative stress responses in antibiotic tolerance in Salmonella typhimurium (2013) (2)
Information measures quantifying aperiodic stochastic (1996) (2)
Wavelets of excitability in sensory neurons. (2001) (2)
Convergent evolution of a genotoxic stress response in a parasite-specific p53 homolog. (2022) (2)
SETDB1 acts as a topological accessory to Cohesin via an H3K9me3-independent, genomic shunt for regulating cell fates (2022) (1)
Data for A novel rotifer derived alkaloid paralyzes schistosome larvae and prevents infection (2019) (1)
Engineering life: Building a FAB for Biology. (Cover story) (2006) (1)
Engineering Models to Scale (2016) (1)
Autocatalytic Gene Expression : In Numero Quantitative Predictions , In Vivo Stochastic Dynamics (2002) (1)
Spike-frequency adaptation improves noise-shaping in model neuronal networks (2000) (1)
Physician incentives in a managed care world. (1994) (1)
A Framework for Addressing Health Issues (2002) (1)
Resource Creating Single-Copy Gen etic Circuits Graphical (2016) (1)
Carbohydrate Ingestion During Exhaustive High-intensity Intermittent Shuttle Running In The Heat: 58 10:45 AM - 11:00 AM (2005) (1)
Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering (2019) (1)
Stochastic and chaos analyses of postural sway: A comparative approach (1994) (1)
Cell Metabolism Perspective Bacterial Metabolism and Antibiotic Efficacy (2019) (1)
Author response: Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni (2013) (1)
Ribocomputing devices for sophisticated in vivo logic computation (2016) (1)
Suppressing arrhythmias in cardiac models with overdrive pacing (2000) (1)
Chapter 1 Electrical stimulation of the somatosensory system (2001) (1)
The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3 (2021) (1)
LIN 28 Regulates Stem Cel l Metabolism and Conversion to Primed Pluripotency Graphical (1)
EFFECT OF ELECTRICAL NOISE ON BALANCE CONTROL IN ELDERLY ADULTS (2002) (1)
Developing a lab-in-a-box and low-cost paper-based sensors for ZIKV and CHIKV diagnosis in Latin America (2021) (1)
A novel rotifer-derived alkaloid paralyzes schistosome larvae and prevents infection (2018) (1)
PLOS Pathogens 2016 Reviewer and Editorial Board Thank You (2017) (1)
Expanding and enhancing our antibacterial arsenal. (2011) (1)
Nesting Results and Initial Habitat Assessment of the Nesting Box Trail for Sialia sialis (Eastern Bluebird) In the Powell River Project Education Center (2007) (1)
35 innovators under 35 2013 (2013) (0)
Single-cell RNA-seq analyses show that long non-coding RNAs are conspicuously expressed in Schistosoma mansoni gamete and tegument progenitor cell populations (2022) (0)
Abstract P5-05-04: Intraductal delivery of RNAi-based therapeutics to gene targets identified through computational systems modeling (2012) (0)
in vitro egg production by the human parasite Schistosoma mansoni (2018) (0)
Author response: Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni (2018) (0)
- Ramirez Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria (2013) (0)
Labeling of the Schistosoma mansoni Tegument. (2020) (0)
The Role of Kinesin-8 Proteins in Kinetochore Movements and Spindle Dynamics in Fission Yeast (2013) (0)
Stochastic Fluctuations in Gene Regulation (2005) (0)
A WhiteBox Machine Learning Approach for Revealing Antibiotic Mechanisms of Action Graphical (2019) (0)
Diagnosis of gene network responsible for cold acclimation in Chinese cabbages (2007) (0)
Neuropeptide signaling in planarian sexual development and regeneration (2011) (0)
Amy Brock Prevents Mammary Tumor Progression in Mice by Intraductal Injection of siRNA Lipidoid Nanoparticles HoxA 1 Silencing (2013) (0)
Design and Construction of Genetic Applets (2003) (0)
Convergent evolution of “genome guardian” functions in a parasite-specific p53 homolog (2021) (0)
Kalghatgi Damage in Mammalian Cells Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative (2013) (0)
Systems-Level Analysis of Stem Cells in the Larval Stage of the Human Parasitic Flatworm Schistosoma (2013) (0)
How stability can lead to variability: Induction timecourse of a eukaryotic gene (2006) (0)
Apparatus to improve balance and gait in humans and prevent foot injuries (2004) (0)
Erratum: Deconstructing transcriptional heterogeneity in pluripotent stem cells (2015) (0)
Systems biology promises to personalize medicine via network-based biomarkers that predict therapeutic effectiveness. Toward this goal, Chang et al. (2009) recently introduced a systems-based approach to break down oncogenic signaling networks into modules that predict the effectiveness of pathway-s (2009) (0)
Reverse engineering gene regulatory networks (2005) (0)
Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation (2013) (0)
CRISPR technologies : a toolkit for making genetically intractable microbes tractable (2018) (0)
Assessing Muscle Sti ness from Quiet Stance : Applicability to Parkinson ' s Disease (2007) (0)
Noise-Enhanced Sensorimotor Function (2004) (0)
Enhancing aperiodic stochastic resonance through noisemodulationCarson (1998) (0)
Author response: Stem cell progeny contribute to the schistosome host-parasite interface (2016) (0)
Gait initiation on toes: a more efficient generation of forward momentum (2000) (0)
The Dynamics of Quasistatic Posture Control (1999) (0)
The effects of visual input on postural stability (1994) (0)
Highly orthogonal programmable riboregulators for complex digital logic in E. Coli (2013) (0)
An Ising model description of sigma-delta data converters (2000) (0)
Foti Bactericidal Antibiotics Oxidation of the Guanine Nucleotide Pool Underlies Cell Death (2012) (0)
Understanding biological regulation through forward synthesis (2018) (0)
Synthetic Biology: Physical Biology by Design (2019) (0)
Schistosome Sulfotransferases: Mode of Action, Expression and Localization (2022) (0)
Stochastic resonance and the tuning of muscle spindles by fusimotor drive (1997) (0)
Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors (2019) (0)
POSTURAL CONTROL AND MUSCLE ACTIVITY DURING QUIET STANDING IN COMMUNITY DWELLING ELDERLY. (2001) (0)
DiSCs – Domains involving SETDB1 and Cohesin are critical regulators of genome topology and stem cell fate (2022) (0)
ICLES Loss of the homeostatic balance with lower glutathione causes an excess of ROSs (2017) (0)
Engineered gene networks (2003) (0)
Microbial community-wide effects of antibiotics (2014) (0)
Tunable protein degradation in bacteria The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2014) (0)
Su2012 - Utility of Self-Expandable Metallic Stent in the Management of Gastric Outlet Obstruction (2018) (0)
The sound of silence: Transgene silencing in mammalian cell engineering (2022) (0)
A Systems Biology Platform for Characterizing Regulatory and Metabolic Pathways that Influence and Control Microbial Hydrogen Production (2013) (0)
How stability can lead to variability: An example from eukaryotic gene expression (2006) (0)
Abstract 4924: Gene network inference models reveal novel key mediators of mammary tumorigenesis (2011) (0)
The good, the bad, and the ugly: From planarians to parasites. (2022) (0)
Motor Control Changes In Ambulatory Elderly (2001) (0)
POSTURAL CONTROL AND GAIT DEFICIENCIES IN ELDERLY ADULTS 892 (1996) (0)
A Pinned Polymer Model of Posture (1995) (0)
Program/Abstract # 414The planarian Schmidtea mediterranea as a free-living model for understanding and controlling flatworm parasites (2011) (0)
Abstract LB-165: Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma (2016) (0)
Bactericidal Antibiotics In duce Toxic Metabolic Perturbations that Lead to Cellular Damage Graphical Abstract Highlights (2015) (0)
Title : High-throughput creation and functional profiling of eukaryotic DNA sequence variant libraries using CRISPR / Cas 9 (2017) (0)
Biophysical Constraints A rising from Compositional Context in Synthetic Gene Networks Graphical (2017) (0)
Chapter 17 – Visualizing the effects of filtering chaotic signals (1998) (0)
Enhancing nutritional niche and host defenses by modifying the gut microbiome (2022) (0)
Reprogramming cell fate : Systemic failures and their mitigation through feedback control (2016) (0)
Abstract 2948: The role of the RNA binding protein LIN28B in neuroblastoma (2012) (0)
Q&A: Circuit capacity (2012) (0)
Forward engineering. Interview by Kristie Nybo. (2012) (0)
Biophysical Constraints Arising From Relative Gene OrientaCompositional Contexttion in Synthetic Gene Networks (2017) (0)
Resource Portable , On-Demand Biomolecular Manufacturing Graphical (2016) (0)
Engineering Gene Regulatory Networks: A Reductionist Approach to Systems Biology (2005) (0)
2017 Argonne Leadership Computing Facility (ALCF) Science Report (2017) (0)
Theta and Mira at Argonne National Laboratory (2019) (0)
HIV-1 infection alters cytokine and chemokine networks that influence innate immunity in the lung (2007) (0)
C. elegans models of Alzheimer's disease and Parkinson's disease: Systems biology identifies an interaction between tau and LRRK2 (2010) (0)
Synthetic Biology as a Tool for Discovery of Biophysical Mechanisms (2016) (0)
2018 Argonne Leadership Computing Facility (ALCF) Science Report (2018) (0)
Review: What is Life? by Ed Regis (2008) (0)
Systems biology: From identifying toxicity pathways to therapeutic engineering (2008) (0)
Diversity-Based Design of Synthetic Gene Networks with Desired Functions (2009) (0)
ASCPT News (2016) (0)
Abstracts of LEAP: Lead, Excel, Achieve, Perform, the UHC Annual Conference 2011. September 21-23, 2011. Chicago, Illinois, USA. (2012) (0)
Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness (2022) (0)
LEAP: Lead, Excel, Achieve, Perform (2012) (0)
Phenotypic consequences of promoter-mediated transcriptional noise: Experiment and computational modeling (2007) (0)

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