Masashi Yanagisawa

Masashi Yanagisawa's AcademicInfluence.com Rankings

Masashi Yanagisawa

Philosophy

#3100

World Rank

#5087

Historical Rank

Logic

#950

World Rank

#1547

Historical Rank

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Philosophy

Masashi Yanagisawa's Degrees

Bachelors Medicine University of Tokyo
Doctorate Medicine University of Tokyo
PhD Medicine University of Tokyo

Why Is Masashi Yanagisawa Influential?

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According to Wikipedia, is a Japanese-American molecular biologist and physician, famous for his discovery of the hormone endothelin and the neuropeptide orexin, the absence of which is the cause of narcolepsy. He is currently the Director of the International Institute for Integrative Sleep Medicine, University of Tsukuba, and an adjunct professor at the Department of Molecular Genetics, University of Texas Southwestern Medical Center.

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Masashi Yanagisawa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) (10772)
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior (1998) (5007)
Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation (1999) (2897)
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. (1989) (2510)
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor (1990) (2427)
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. (1993) (1851)
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002) (1543)
Differential expression of orexin receptors 1 and 2 in the rat brain (2001) (1499)
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity (2001) (1375)
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008) (1368)
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. (2001) (1195)
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. (1999) (1018)
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice (1994) (987)
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons (1994) (935)
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 (1994) (925)
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice (2003) (870)
A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease (1994) (866)
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation (2013) (798)
Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome (2003) (777)
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. (1977) (765)
Endothelin system: the double-edged sword in health and disease. (2001) (738)
To eat or to sleep? Orexin in the regulation of feeding and wakefulness. (2001) (722)
Distribution of orexin neurons in the adult rat brain 1 Published on the World Wide Web on 17 March 1999. 1 (1999) (704)
Fos Expression in Orexin Neurons Varies with Behavioral State (2001) (657)
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. (1998) (650)
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. (2013) (650)
Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes (2003) (609)
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. (2004) (605)
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo (2002) (587)
INCREASED PLASMA CONCENTRATIONS OF ENDOTHELIN-1 AND BIG ENDOTHELIN-1 IN ACUTE MYOCARDIAL INFARCTION (1989) (577)
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress (2008) (560)
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. (1988) (524)
Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells. (1989) (517)
Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum (*) (1995) (494)
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. (1998) (491)
A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. (1989) (482)
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. (1989) (425)
Molecular and Cellular Mechanism of Endothelin Regulation: Implications for Vascular Function (1991) (408)
Orexin (Hypocretin) Neurons Contain Dynorphin (2001) (400)
Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells (1989) (390)
Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. (1988) (388)
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin (1988) (386)
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. (2003) (383)
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion (2002) (382)
Behavioral State Instability in Orexin Knock-Out Mice (2004) (368)
Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. (1989) (364)
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published on the World Wide Web on 27 June 2000. (2000) (351)
Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal (2003) (348)
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA (1989) (347)
Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia. (1989) (346)
Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition (2010) (333)
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. (2003) (331)
Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner (2010) (331)
Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide? (1989) (331)
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. (2004) (321)
Attenuated defense response and low basal blood pressure in orexin knockout mice. (2003) (321)
Endothelin: a novel peptide in the posterior pituitary system. (1990) (318)
Induction of Endothelin‐1 Gene by Angiotensin and Vasopressin in Endothelial Cells (1992) (315)
Endothelin, a novel vasoconstrictor peptide, as potent bronchoconstrictor. (1988) (312)
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity (2004) (309)
Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes. (1988) (307)
A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels (1988) (306)
Endothelin: 20 years from discovery to therapy. (2008) (302)
Salt-sensitive hypertension in endothelin-B receptor-deficient rats. (2000) (301)
An essential role for orexins in emergence from general anesthesia (2008) (298)
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker (2006) (292)
Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia (1999) (278)
Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. (1990) (274)
Cloning and functional expression of human cDNA for the ETB endothelin receptor. (1991) (266)
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice (2005) (264)
Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. (1991) (261)
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. (2009) (258)
Molecular characterization of endothelin receptors. (1992) (255)
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus (2004) (251)
Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. (2004) (248)
Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats. (1988) (242)
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. (1991) (237)
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice (2005) (234)
An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients (2008) (234)
Physiology and pharmacology of endothelins (1992) (228)
Binding and receptor down‐regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells (1988) (226)
Molecular biology and biochemistry of the endothelins. (1989) (221)
Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight (1999) (219)
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep (2011) (215)
Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. (1996) (215)
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. (2003) (214)
Structure-activity relationships of endothelin: importance of the C-terminal moiety. (1988) (214)
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. (2009) (211)
The endothelin system. A new target for therapeutic intervention. (1994) (210)
Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines. (1991) (209)
Orexin Neurons Function in an Efferent Pathway of a Food-Entrainable Circadian Oscillator in Eliciting Food-Anticipatory Activity and Wakefulness (2004) (206)
Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. (1998) (204)
Structure and Function of Human Prepro-orexin Gene* (1999) (201)
Forward-genetics analysis of sleep in randomly mutagenized mice (2016) (200)
Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. (2000) (195)
Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models (2009) (195)
Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. (2000) (194)
Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats (2003) (188)
Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. (1998) (187)
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions (2005) (187)
The Human Preproendothelin‐1 Gene: Possible Regulation by Endothelial Phosphoinositide Turnover Signaling (1989) (186)
Conversion of Big Endothelin‐1 to 21‐Residue Endothelin‐1 Is Essential for Expression of Full Vasoconstrictor Activity: Structure‐Activity Relationships of Big Endothelin‐1 (1989) (178)
Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells. (1990) (178)
Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat (2004) (177)
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 (2003) (175)
Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons (2008) (175)
Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines. (1997) (173)
Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. (1992) (171)
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease (2014) (168)
Two distinct types of endothelin receptors are present on chick cardiac membranes. (1989) (168)
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. (1993) (160)
Hypertension associated with endothelin-secreting malignant hemangioendothelioma. (1991) (160)
COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis (2009) (160)
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. (2006) (158)
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide. (2005) (158)
Complete primary structure of vertebrate smooth muscle myosin heavy chain deduced from its complementary DNA sequence. Implications on topography and function of myosin. (1987) (157)
Widespread distribution of orexin in rat brain and its regulation upon fasting. (1999) (154)
Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation (2002) (149)
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (2004) (146)
Cerebral microvessel endothelium is producing endothelin (1990) (144)
Endothelin acts in feline and canine cerebral arteries from the adventitial side. (1989) (142)
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. (2005) (140)
Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. (2007) (140)
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. (2001) (139)
Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. (1995) (138)
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need (2018) (138)
Endothelin localizes in the dorsal horn and acts on the spinal neurones: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release (1989) (138)
Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects. (1992) (137)
Persistent pain and stress activate pain-inhibitory orexin pathways (2005) (136)
Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. (1989) (135)
Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms (2015) (134)
Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression (2008) (132)
Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. (2001) (132)
Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage (1990) (131)
Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture (2009) (130)
Endothelin: new discoveries and rapid progress in the clinic. (1998) (129)
Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: contribution of phosphoinositide turnover. (1989) (125)
Elimination of Intravenously Injected Endothelin‐1 from the Circulation of the Rat (1989) (124)
Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors (2002) (124)
Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells. (1990) (123)
Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice (2008) (123)
Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3. (1991) (121)
In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1. (2000) (119)
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. (2002) (119)
Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. (2014) (117)
Two distinct nonmuscle myosin-heavy-chain mRNAs are differentially expressed in various chicken tissues. Identification of a novel gene family of vertebrate non-sarcomeric myosin heavy chains. (1989) (113)
Two different forms of endothelin receptors in rat lung (1989) (113)
Production of endothelin-1 by rat cultured mesangial cells. (1990) (110)
Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. (1989) (109)
Cloning and characterization of a novel endothelin receptor subtype in the avian class. (1998) (109)
A discrete neuronal circuit induces a hibernation-like state in rodents (2020) (108)
Orexins Acting at Native OX1 Receptor in Colon Cancer and Neuroblastoma Cells or at Recombinant OX1 Receptor Suppress Cell Growth by Inducing Apoptosis* (2004) (108)
Deletion of Endothelial Cell Endothelin B Receptors Does Not Affect Blood Pressure or Sensitivity to Salt (2006) (108)
Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoactive peptide. (1989) (106)
Endothelin: 30 Years From Discovery to Therapy. (2019) (105)
Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. (2005) (104)
Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells. (1993) (102)
Low Blood Pressure in Endothelial Cell–Specific Endothelin 1 Knockout Mice (2010) (98)
Characteristics of Pressor Response to Endothelin in Spontaneously Hypertensive and Wistar‐Kyoto Rats (1989) (98)
Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. (2005) (97)
Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation (2013) (96)
Endothelin–3 frameshift mutation in congenital central hypoventilation syndrome (1996) (96)
Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination. (1989) (96)
Vascular Endothelin-B Receptor System In Vivo Plays a Favorable Inhibitory Role in Vascular Remodeling After Injury Revealed by Endothelin-B Receptor–Knockout Mice (2002) (93)
Novel Mutations of the Endothelin B Receptor Gene in Patients with Hirschsprung’s Disease and Their Characterization* (1998) (90)
Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy (2004) (90)
Primary structure of chicken skeletal muscle and fibroblast alpha-actinins deduced from cDNA sequences. (1988) (90)
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models (2017) (89)
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR 41 (2004) (89)
A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2* (2004) (89)
Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. (2001) (88)
The Possible Role of Endothelin‐1 in the Pathogenesis of Coronary Vasospasm (1989) (88)
Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. (2007) (87)
Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. (2009) (85)
Endotoxin and pro‐inflammatory cytokines stimulate endothelin‐I expression and release by airway epithelial cells (1994) (84)
Effects of orexin (hypocretin) on GIRK channels. (2003) (84)
N-Type Calcium Channel α1B Subunit (CaV2.2) Knock-Out Mice Display Hyperactivity and Vigilance State Differences (2003) (84)
Role of Endothelin 1 in the Pathogenesis of Chronic Chagasic Heart Disease (2005) (84)
Cardiomyocyte-Specific Endothelin A Receptor Knockout Mice Have Normal Cardiac Function and an Unaltered Hypertrophic Response to Angiotensin II and Isoproterenol (2003) (84)
Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1. (1989) (84)
Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation. (2009) (83)
Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. (2014) (83)
Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. (2008) (82)
Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells. (1991) (82)
An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep (2016) (82)
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. (2015) (82)
IGFBP3 Colocalizes with and Regulates Hypocretin (Orexin) (2009) (81)
Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse (1997) (79)
Elevated plasma levels of endothelin-1 in systemic sclerosis. (1991) (79)
Modulation of Circadian Glucocorticoid Oscillation via Adrenal Opioid-CXCR7 Signaling Alters Emotional Behavior (2013) (78)
Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. (2001) (78)
Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats. (2002) (77)
Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide (1988) (76)
Endothelin, a novel endothelium-derived peptide. Pharmacological activities, regulation and possible roles in cardiovascular control. (1989) (76)
Mechanism of contraction to endothelin in isolated porcine coronary artery. (1989) (76)
Role of tyrosine kinase pathways in ETB receptor activation of NHE3. (1996) (76)
Distinct vascular and intestinal smooth muscle myosin heavy chain mRNAs are encoded by a single-copy gene in the chicken. (1990) (76)
Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice. (1999) (75)
Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. (2016) (75)
SOX6 Attenuates Glucose-stimulated Insulin Secretion by Repressing PDX1 Transcriptional Actvity and Is Down-regulated in Hyperinsulinemic Obese Mice* (2005) (75)
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. (1996) (74)
ETB receptor activation leads to activation and phosphorylation of NHE3. (1999) (73)
Orexin Gene Transfer into Zona Incerta Neurons Suppresses Muscle Paralysis in Narcoleptic Mice (2011) (72)
Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. (1993) (72)
Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme. (1990) (69)
ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy. (2012) (69)
Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States (2013) (68)
Endothelin‐1 Acts in Cerebral Arteries from the Adventitial but Not from the Luminal Side (1989) (67)
Presence and distribution of endothelin-1 gene expression in human kidney. (1994) (66)
Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy (2013) (66)
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice (2008) (65)
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B (2009) (65)
Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. (1990) (64)
Immunoreactive Endothelin‐1 in Plasma Detected by a Sandwich‐Type Enzyme Immunoassay (1989) (64)
Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice (2013) (64)
Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation (2020) (63)
Exaggerated Vascular and Renal Pathology in Endothelin-B Receptor–Deficient Rats With Deoxycorticosterone Acetate–Salt Hypertension (2000) (63)
Human melanoma cells express functional endothelin-1 receptors. (1994) (63)
Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat. (1995) (62)
Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons (2003) (61)
The expression pattern of endothelin 3 in the avian embryo (1998) (60)
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo. (2020) (60)
Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice (2014) (59)
ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells. (2001) (58)
Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells. (1998) (57)
Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus. (1999) (57)
Renal Vasoconstriction by the Endothelial Cell-Derived Peptide Endothelin in Spontaneously Hypertensive Rats (1989) (56)
Complete primary structure and tissue expression of chicken pectoralis M-protein. (1992) (56)
Heterozygous Knock-Out of ETB Receptors Induces BQ-123–Sensitive Hypertension in the Mouse (2000) (56)
Prevention of cerebral vasospasm by actinomycin D. (1991) (55)
Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts. Developmental changes in mechanical responses and receptor subtypes. (1991) (55)
Histamine‐1 receptor is not required as a downstream effector of orexin‐2 receptor in maintenance of basal sleep/wake states (2010) (55)
Binding Sites for Endothelin‐1 in Rat Tissues: An Autoradiographic Study (1989) (55)
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain. (2005) (54)
Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid. (1990) (54)
The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis. (2003) (54)
Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. (2012) (54)
[Endothelin: a novel endothelium-derived peptide]. (1989) (54)
Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain (2004) (52)
Cholinergic Modulation of Narcoleptic Attacks in Double Orexin Receptor Knockout Mice (2011) (52)
Similarity of endothelin to snake venom toxin (1988) (51)
Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development. (2003) (51)
Constitutive Lysosomal Targeting and Degradation of Bovine Endothelin-converting Enzyme-1a Mediated by Novel Signals in Its Alternatively Spliced Cytoplasmic Tail* (1999) (51)
Endothelin-1 Stimulates Leptin Production in Adipocytes* (2001) (50)
ENDOTHELIN IN THE CENTRAL CONTROL OF CARDIOVASCULAR AND RESPIRATORY FUNCTIONS (1999) (49)
Involvement of the serotonergic system in orexin-induced behavioral alterations in rats (2002) (49)
Endothelin‐1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet‐induced melanocyte homeostasis (2013) (48)
α-Synuclein BAC transgenic mice exhibited RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model. (2019) (48)
Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: implications for luteolysis. (2001) (48)
Novel selective quinazoline inhibitors of endothelin converting enzyme-1. (1998) (48)
Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity (2004) (48)
Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models (2006) (48)
Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice. (1999) (47)
dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. (2003) (46)
Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain (1989) (46)
Endothelin-1 and its receptors in human testis. (1995) (45)
Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy (2013) (45)
Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland. (1992) (45)
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018) (44)
A pertussis toxin‐sensitive mechanism of endothelin action in porcine coronary artery smooth muscle (1992) (43)
Ectopic Overexpression of Orexin Alters Sleep/Wakefulness States and Muscle Tone Regulation during REM Sleep in Mice (2011) (43)
Mechanisms of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and Wistar-Kyoto rats. (1991) (43)
Animals lacking endothelin‐converting enzyme‐2 are deficient in learning and memory (2008) (42)
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice (2018) (42)
Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain (2006) (41)
Endothelin, its diverse biological activities and mechanisms of action. (1989) (41)
Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice (2000) (41)
Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents (2009) (41)
Impaired Ventilatory Responses to Hypoxia in Mice Deficient in Endothelin-Converting-Enzyme-1 (2001) (40)
Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts. (1998) (40)
The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo (1998) (40)
Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway* (2014) (39)
An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3. (2004) (38)
Different Contributions of Endothelin-A and Endothelin-B Receptors in Postischemic Cardiac Dysfunction and Norepinephrine Overflow in Rat Hearts (2005) (38)
The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice (2003) (38)
Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice (2020) (37)
Extrarenal ETB Plays a Significant Role in Controlling Cardiovascular Responses to High Dietary Sodium in Rats (2005) (37)
Endothelins: vasoconstrictor effects and localization in canine cerebral arteries (1991) (37)
A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture. (1996) (36)
Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor. (2009) (36)
Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. (2006) (36)
Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats. (1996) (35)
A novel mouse model for de novo Melanoma. (2010) (35)
Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome-mediated endothelin-1 gene transfer. (1997) (34)
Endothelin-1 in luteal tissue (1991) (34)
Endothelin A receptor is necessary for O(2) constriction but not closure of ductus arteriosus. (1999) (34)
Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action. (2014) (34)
Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats. (2004) (33)
Reduced Expression of the Endothelin Receptor Type B Gene in Piebald Mice Caused by Insertion of a Retroposon-like Element in Intron 1* (2006) (33)
Peripherally administered orexin improves survival of mice with endotoxin shock (2016) (33)
Decreased Intake of Sucrose Solutions in Orexin Knockout Mice (2011) (33)
EXPRESSION OF ENDOTHELIN‐1 IN PANCREATIC TISSUE OF PATIENTS WITH CHRONIC PANCREATITIS (1996) (33)
Endothelin receptors in human parathyroid gland. (1992) (33)
Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. (2013) (32)
Cyclic Expression of Endothelin-converting Enzyme-1 Mediates the Functional Regulation of Seminiferous Tubule Contraction (1999) (32)
G protein-coupled receptor genes in the FANTOM2 database. (2003) (32)
Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation. (2000) (32)
Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons (2010) (32)
Differential Roles of Each Orexin Receptor Signaling in Obesity (2019) (31)
Hypocretin/orexin deficiency decreases cocaine abuse liability (2018) (31)
Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice (2005) (30)
Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction (2017) (30)
Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. (2005) (30)
Critical Role of Neuropeptides B/W Receptor 1 Signaling in Social Behavior and Fear Memory (2011) (30)
Role of endothelin in the development of Dahl hypertension. (1991) (30)
Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. (2014) (30)
Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor. (1994) (30)
Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration (2013) (30)
Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading (2005) (29)
Dlx5/6‐enhancer directed expression of Cre recombinase in the pharyngeal arches and brain (2003) (29)
Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep (2010) (29)
Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling (2014) (29)
Regulation of Postnatal Trabecular Bone Formation by the Osteoblast Endothelin A Receptor (2011) (28)
Monoaminergic neuronal changes in orexin deficient mice (2010) (28)
Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. (2002) (28)
Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. (1993) (27)
Intracellular localization of membrane-bound endothelin-converting enzyme from rat lung. (1993) (27)
Loss of Function of Endothelin-2 Leads to Reduced Ovulation and CL Formation (2014) (27)
QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior (2016) (27)
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. (2017) (27)
Cardiovascular Effects of the Endothelins (1990) (26)
Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion (2010) (26)
Two isoforms of smooth muscle myosin regulatory light chain in chicken gizzard. (1989) (26)
Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice. (2000) (26)
Analysis of big endothelin-1 digestion by cathepsin D. (1990) (25)
MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks (2019) (25)
Acid regulation of NaDC-1 requires a functional endothelin B receptor. (2010) (25)
Plasma concentrations of endothelin-1 and endothelin-3 are altered differently in various pathophysiological conditions in humans. (1991) (25)
Identification of the Endothelin‐1 Receptor in the Chick Heart (1989) (25)
Enhanced blood pressure sensitivity to DOCA‐salt treatment in endothelin ETB receptor‐deficient rats (2000) (25)
Analysis of C5a receptor by monoclonal antibody. (1995) (25)
Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response (2018) (24)
Possible role of endothelin in the pathogenesis of cerebral vasospasm. (1991) (24)
GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice (2015) (23)
Endothelin b receptor deficient transgenic rescue rats: a rescue phenomenon in the brain (2004) (23)
Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. (2016) (23)
Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse (2013) (22)
Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension. (2002) (22)
Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients. (2000) (22)
In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats. (1998) (22)
Behavioral state instability in orexin knockout mice (2004) (22)
Endothelin‐1 Depolarizes a Ventral Root Potential in the Newborn Rat Spinal Cord (1989) (22)
Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice (2019) (21)
Endothelin‐1 as a master regulator of whole‐body Na+ homeostasis (2015) (21)
Deletion of the endothelin-A receptor gene within the developing mandible (2005) (21)
Amino acid sequence studies on cytolytic toxins from sea anemone Heteractis magnifica, Entacmaea quadricolor and Stichodactyla mertensii (Anthozoa). (2000) (20)
Localization of endothelin-converting enzyme-1 in human kidney. (1997) (20)
Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing (2014) (20)
Endothelial ETB Limits Vascular Remodelling and Development of Pulmonary Hypertension during Hypoxia (2009) (20)
Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice (2014) (20)
Co-expression of endothelin-1 and endothelin-converting enzyme-1 in patients with chronic rhinitis. (1996) (20)
Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy (2018) (20)
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need (2020) (19)
Role of endothelin in mechanisms of local blood pressure control. (1990) (19)
Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery. (1997) (19)
Arginine-vasopressin increases the release of ET-1 into perfusate of rat mesenteric artery. (1993) (19)
Mechanisms of endothelin-1 mRNA and peptides induction by TGF-beta and TPA in MDCK cells. (1991) (18)
Octacosanol restores stress-affected sleep in mice by alleviating stress (2017) (18)
Pseudo-noncompetitive antagonism by BQ123 of intracellular calcium transients mediated by human ETA endothelin receptor. (1994) (18)
Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1. (2002) (18)
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension (2021) (18)
ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy. (2002) (18)
Partial Requirement of Endothelin Receptor B in Spiral Ganglion Neurons for Postnatal Development of Hearing* (2011) (18)
Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium‐Derived Endothelin‐1 (2018) (18)
Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain (2004) (17)
Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats (2018) (17)
Polarized secretion of endothelin-1 and big ET-1 in MDCK cells is inhibited by cell Na+ flux and disrupted by NH4Cl. (1991) (17)
Affinity labelling of endothelin receptor and characterization of solubilized endothelin-endothelin-receptor complex. (1990) (17)
Heparin suppresses endothelin-1 peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats. (1994) (16)
Monoclonal antibodies to endothelin: application for sandwich immunoassays. (1990) (16)
Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice (2020) (16)
Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates (2017) (16)
Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice. (1998) (16)
Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis (2003) (16)
The ligand-receptor interactions of the endothelin systems are mediated by distinct "message" and "address" domains. (1993) (16)
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain. (2018) (16)
Endothelin: 20 years from discovery to therapy 1 (2008) (15)
T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α (2017) (15)
Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/-) knockout mice under anaesthesia. (2002) (15)
Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice (2019) (15)
Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. (2005) (14)
Phosphoinositide turnover signaling stimulated by ET-3 in endothelial cells from spontaneously hypertensive rats. (1994) (14)
High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. (2016) (14)
Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. (2016) (14)
Deletion of the endothelin-A-receptor suppresses oxygen-induced constriction but not postnatal closure of the ductus arteriosus. (2000) (14)
Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice (2016) (13)
Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis. (2012) (13)
Comparison of endothelin-1 concentrations in normal and complicated pregnancies. (1991) (13)
A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1. (2005) (13)
Exaggerated Vascular and Renal Pathology in Endothelin-B-receptor-deficient Rats with Subtotal Nephrectomy (2004) (13)
Endothelin-secreting tumor. (1991) (13)
Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats. (2000) (12)
Effect of endothelin receptor antagonist, BQ-123, on Ca2+ signaling in cultured rat mesangial cells. (1993) (12)
Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats. (2004) (12)
Attenuated cold defense responses in orexin neuron-ablated rats (2016) (12)
Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. (2021) (12)
Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3. (2000) (12)
Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening (2019) (12)
Tissue-specific modulation of endothelin receptors in a rat model of hypertension. (2000) (12)
ETB receptor activation leads to activation and phosphorylation of NHE3. (1999) (11)
Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice (2020) (11)
Localization of endothelin-converting enzyme-1 in human kidney. (1997) (11)
Ventilatory long-term facilitation in mice can be observed both during sleep and wake periods and depends on orexin (2007) (11)
Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis (2015) (11)
Increased plasma concentrations of endothelin-1 during and after pulmonary surgery. (1991) (10)
Pressor response to endothelin in guinea pigs. (1989) (10)
Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice (2018) (10)
Mesolimbic neuropeptide W coordinates stress responses under novel environments (2016) (10)
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor. (2017) (10)
Endothelin in perinatal pharmacology. (1991) (10)
Cardiovascular effects of endothelin. (1992) (10)
Solubilization of two types of endothelin receptors, ET(A) and ET(B), from rat lung with retention of binding activity (1991) (10)
Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling (2015) (10)
Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities (2008) (9)
Amino acid sequence of two neurotoxins from the venom of the Egyptian black snake (Walterinnesia aegyptia). (1997) (9)
Isolation of anti-endothelin receptor monoclonal antibodies for use in receptor characterization. (1990) (9)
Expression of endothelin-like peptide in the nervous system of the marine mollusk Aplysia. (1991) (9)
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity. (2017) (9)
Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. (2018) (9)
Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial (2020) (9)
Endothelin activates the dihydropyridine-sensitive , voltage-dependent Ca 2 + channel in vascular smooth muscle ( Ca 2 +-channel blocker / whole-cell patch clamp / aequorin / endothelium / porcine coronary artery ) (2003) (8)
25 years of endothelin research: the next generation. (2014) (8)
Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice (2019) (8)
Endothelium-Derived Novel Vasoconstrictor Peptide Endothelin: A Possible Endogenous Agonist for Voltage-Dependent Ca2+ Channels (1988) (8)
Metabolic responses to polychromatic LED and OLED light at night (2021) (8)
Localization of orexin B and orexin-2 receptor in the rat epididymis. (2018) (8)
Cellular mechanism of vasoconstriction induced by endothelin. (1990) (8)
Identification of mutations through dominant screening for obesity using C57BL/6 substrains (2016) (8)
Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer. (1998) (8)
Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice. (2021) (8)
A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain (2019) (7)
The effect of phenobarbital on human plasma lipids. (1989) (7)
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring. (2019) (7)
Endothelin B receptor is not required but necessary for finite regulation of ovulation. (2012) (7)
Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need (2021) (7)
Endothelin induces DNA polymerase alpha activity in ovaries of hypophysectomized estrogen-treated immature rats. (1991) (7)
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. (2019) (6)
Correction to Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496] (2015) (6)
Erratum: Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice (Neuron (April 21, 2005) 46 (297-308) PII: S0896-6273(05)00205-9 and DOI: 10.1016/j.neuron.2005.03.010) (2005) (6)
Study on the endothelin gene and its expression. (1990) (6)
Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine. (2020) (6)
Molecular genetic dissection of the endothelin system (1995) (6)
The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice (2021) (5)
Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice (2020) (5)
Increased sensitivity to endothelin-1 in spontaneously hypertensive rats is closely related to resting membrane potential (1990) (5)
Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors (2015) (5)
Endothelin XII. (2012) (5)
Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process. (2020) (5)
vascular function Molecular and cellular mechanism of endothelin regulation. Implications for (2011) (5)
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton (2021) (5)
TaqI polymorphism at the human preproendothelin-1 gene (EDN1). (1991) (5)
Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction (2020) (5)
Interaction between Orexin Neurons and Monoaminergic Systems. (2021) (5)
MASC: Automatic Sleep Stage Classification Based on Brain and Myoelectric Signals (2017) (5)
Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats. (2000) (5)
574 Evidence for an endothelin-1 autocrine loop in lung cancer (1997) (4)
The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ETB knockout rats (2020) (4)
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway (2020) (4)
Uremic serum contains humoral factor(s) larger than fifty kilodaltons which suppresses endothelin production in cultured endothelial cells. (1991) (4)
Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture (2007) (4)
The Second Tomoh Masaki Award (2013). (2014) (4)
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease (2015) (4)
Association of wood use in bedrooms with comfort and sleep among workers in Japan: a cross-sectional analysis of the SLeep Epidemiology Project at the University of Tsukuba (SLEPT) study (2020) (4)
Enhanced cortical responsiveness during natural sleep in freely behaving mice (2020) (4)
The Response Behavior of PAA-B12C4 Electrode to Li+, Mg2+, and Ca2+ in Some Aprotic Solvents and Its Thermodynamic Application. (1999) (4)
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. (2021) (3)
Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study (2021) (3)
Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a. (2002) (3)
Discovery of Orexin 2 Receptor Selective and Dual Orexin Receptor Agonists based on the Tetralin Structure: Switching of Receptor Selectivity by Chirality on the Tetralin Ring (2022) (3)
Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders (2020) (3)
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives (2022) (3)
Functional ETA-ETB Receptor Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats (2016) (3)
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. (2019) (3)
Effects of Endothelin on Cerebral Arteries and Its Possible Role in the Pathogenesis of Cerebral Vasospasm (1990) (3)
Improvement of Slow Wave Sleep Continuity by Mattress with Better Body Pressure Dispersal (2019) (3)
Interleukin-2 Suppresses Endothelin-1 Secretion of Cultured Endothelial Cells (1992) (3)
Endothelin XIII. (2014) (2)
The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013. (2014) (2)
Endothelin-induced vasoconstriction of cerebral and peripheral arteries of dogs (1990) (2)
Lessons from sleepy mice: Narcolepsy-cataplexy and the orexin neuropeptide system (2006) (2)
培養内皮細胞でプレプロエンドセリン、組織因子、癌原遺伝子の転写を増強する腫瘍壊死因子カケクチン (1991) (2)
Sleep State Analysis Using Calcium Imaging Data by Non-negative Matrix Factorization (2019) (2)
Endothelin Action and Production in Renal Tubular Cells (1991) (2)
Differential tissue expression of multiple genes for chicken smooth muscle/nonmuscle myosin regulatory light chains. (1992) (2)
ET-B receptors in podocytes promote diabetic glomerulosclerosis with β-catenin and NFκB activation (2013) (2)
Rodent Models of Human Narcolepsy-cataplexy (2005) (2)
Endothelins: Recent Progress (1995) (2)
Hypothalamic orexin system: from orphan GPCR to therapeutic target. (2011) (2)
[Difference in MRI findings and risk factors between multiple infarction without dementia and multi-infarct dementia]. (1995) (2)
[Development of a Therapeutic Drug for Narcolepsy]. (2018) (2)
Mechanisms of increased sensitivity to endothelin-1 in aorta from spontaneously hypertensive rats (1990) (2)
Characterization of the effect of endothelins in canine cerebral arteries. (1991) (2)
Metabolic flexibility during sleep (2021) (2)
Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP Swe Alzheimer’s Disease Mouse Model (2021) (1)
Enhanced Orexin Neuropeptide Signaling Prevents Features of Metabolic Syndrome in Mice: 967 (2009) (1)
The commensal bacteria metabolites short chain fatty acids positively regulate epithelial innate immune responses in the gut (MUC4P.847) (2014) (1)
Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer’s Disease Mouse Model (2022) (1)
Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity. (2022) (1)
Diversity of Pharmacological Responses of Endothelin (1990) (1)
Free Communication Abstracts (2005) (1)
Assignment of the murine protein kinase gene DLK to chromosome 15 in the vicinity of the bt/Koa locus by genetic linkage analysis. (1997) (1)
Endothelin-2 Is Required for Both Ovulation and Corpus Luteum Formation. (2012) (1)
Sympathetic endothelin A receptors contribute to the development of heart failure (2013) (1)
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors. (2022) (1)
Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation. Kumar et al. -2 (2020) (1)
Abstract 1050: Abnormal Lung Alveolarization In The ET-2 deficient Mouse Model: Possible Role Of ET-2 In Pulmonary Vasculature Development (2007) (1)
Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β (2020) (1)
Detection of endothelin-1 in the human plasma and in the perfusate of rat mesenteric artery (1990) (1)
Toward the Mysteries of Sleep. (2019) (1)
-1050-STUDY OF THE VENOUS PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN NORMAL AND HYPERTENSIVE SUBJECTS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY (1990) (1)
Urinary protein profiling with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry in ETB receptor-deficient rats. (2008) (1)
Primary structure, synthesis, andbiological activity ofrat endothelin, anendothelium-derived (1988) (1)
Amino acid sequence of two cytolytic sea anemone toxins (1995) (1)
OREXIN ( HYPOCRETIN ) EFFECTS ON GIRK CHANNELS (2003) (1)
Author response: Peripherally administered orexin improves survival of mice with endotoxin shock (2016) (1)
Structure of cortical network activity across natural wake and sleep states in mice (2020) (1)
Increased sensitivity to endothelin-1 in aorta from hypertensive rats (1990) (0)
The effects of sleep on the cardiovascular and the thermoregulatory systems – possible role for hypocretin (2009) (0)
Functional significance of myocyte endothelin-1 in experimental chronic chagasic cardiomyopathy (2002) (0)
Obesity, hyperglycemia and bone abnormalities of Sik3 gene mutant mice. (2017) (0)
Orexin knockout mice exhibit attenuated respiratory long-term facilitation (2007) (0)
Three structurally and functionally distinct isopeptides of human endothelin predicted by three separate genes (1989) (0)
2406 Participation of the endothelin-1-endothelin a receptor system in the central neural control of circulation and respiration (1997) (0)
Endothelin: Cardiorespiratory abnormalities in endothelin - and endothelin receptor knockout mice (1998) (0)
Exaggerated Pulmonary Vasoconstrictor Response to Acute Hypoxia in the Endothelin B Receptor Deficient Rat (1999) (0)
Abstract 1196: Vascular Endothelial Cells specific Endothelin-1 mediates Early Inflammation in Murine Model of Neointimal Formation (2007) (0)
-0795-ALTERATIONS OF PLASMA ENDOTHELIN LEVELS BY STRENOUS ENDURANCE TRAINING IN ATHLETES (1990) (0)
Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 11, (4459-4464) DOI: 10.1073/pnas.0811126106) (2009) (0)
Increased sleep need in mice lacking the PKA phosphorylation site in SIK1 and SIK2 (2019) (0)
Novel quinazoline endothelin converting enzyme inhibitors (1996) (0)
Peripheral venous plasma levels of endothelin family in healthy subjects and patients with chronic hemodialysis. (1991) (0)
The effect of zonisamide on abnormal muscle tone during REM sleep in a mouse model of REM sleep behavior disorder (2017) (0)
2P234 GABAergic inhibition of noradrenergic neurons through orexin type 2 receptors(16. Neuronal Circuit & Information processing,Poster) (2013) (0)
Deciphering a novel neural circuit in the central amygdala implicated in regulation of social behavior (2019) (0)
Tomoh Masaki. (2020) (0)
TWO PROBLEMS ON SMOOTH MUSCLE CONTRACTION IN RELATION TO CALCIUM ION (1989) (0)
Abstract 1656: Attenuation of Diet-Induced Obesity, Hypertension and Insulin Resistance in Vascular Endothelial Endothelin-1 Knockout Mice (2006) (0)
Corrigendum to “Transient expression of neuropeptide W in postnatal mouse hypothalamus – A putative regulator of energy homeostasis” [Neuroscience 301 (2015) 323–337] (2015) (0)
OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models (2020) (0)
PERO: A stress-free, quantitative oral administration method through voluntary licking behavior (2019) (0)
Blood pressure of endothelin-3 null (fi/fi) knockout mice and endothelin A receptor null (fi/fi) knockout mice under anaesthesia (2002) (0)
[113th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Sleep Disorders and Systemic Diseases: Genetics and Neuroscience of Sleep]. (2016) (0)
PE-312 Endothelial Cell-derived Endothelin-1 Regulates Proteinuria and Glomerular Barrier Function in Diabetic Mice(PE053,Peripheral Circulation/Vascular Disease (Therapy), Kidney/Renal Circulation/CKD (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ (2009) (0)
Imaging Sleep and Wakefulness (2019) (0)
Endothelium-mediated actions of the ANP/cGMP system (2005) (0)
Endothelin produces vasoconstrictions more potently in the resistance portion than in the conduit portion of human mesenteric arteries (1990) (0)
Establishment of EEG/EMG recording method for very young mouse before weaning (2016) (0)
Endothelin-1 is a transcriptional target of p 53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis (2013) (0)
OE-307 Endothelial cell-specific inactivation of ET-1 protects mice against pulmonary hypertension and right ventricular hypertrophy(Hypertension, Basic 3 (H) : OE39)(Oral Presentation (English)) (2004) (0)
My Prior Research and Clinical Training (0)
Effect of endothelin on cardiovascular system (1990) (0)
Hypoxia ameliorates the wound healing ability of extracellular vesicle (EVs) derived from adipose tissue-mesenchymal stem cells (AT-MSCs) (2018) (0)
Abstract 15399: Endothelin-1 Knockdown From Endothelial Cells Reduce Kidney Fibrosis, Peritubular Capillary Loss and Tubular Damage in Unilateral Ureteral Obstruction Model in Mice (2011) (0)
Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy (2004) (0)
Acute behavioral stress‐induced circulating endothelin‐1 is derived from the endothelium (857.9) (2014) (0)
2P233 Functional connection between GABAergic neurons in the preoptic area and orexinergic neurons in the hypothalamus(16. Neuronal Circuit & Information processing,Poster) (2013) (0)
tissue simultaneously with blood vessel morphogenesis The embryo makes red blood cell progenitors in every (2013) (0)
In vitro and in vivo pharmacology of YNT-X, a novel small-molecule orexin type 2 receptor agonist (2019) (0)
Pharmacological properties of cloned human endothelin receptor subtypes (1992) (0)
Chronic orexin receptor blockage induces narcoleptic behavior by reducing orexin peptide synthesis in mice (2019) (0)
Attenuation of hypercapnic chemoreflex in orexin knockout mice (2005) (0)
Endothelial Cell-specific Endothelin-1 Knockout Mice Have Impared Cardiac Function and Increased Cardiac Fibrosis under the Chronic Pressure Overload Condition (Heart Failure, Basic 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society) (2005) (0)
Orexin is necessary both for hypercapnic ventilatory responses during awake state and for prevention of sleep apneas (2007) (0)
Orexin is necessary for eliciting ventilatory long‐term facilitation in mice (2007) (0)
Association of self-rated sleep apnea with hypertension, dyslipidemia and diabetes mellitus: slept study (2019) (0)
Collecting duct NOS1 knockout mice lack ET-1 mediated inhibition of collecting duct ENaC (2014) (0)
INVOLVEMENT OF OREXIN IN DEFENSE RESPONSE AND CENTRAL DETERMINATION OF SYMPATHETIC OUTFLOW: OP 030 (2004) (0)
The Basic Rest-Activity Cycle (BRAC) is present in transgenic rats with ataxin3-mediated destruction of orexin neurons, but amplitudes of the BRAC-associated brown adipose tissue and body temperature change are reduced. (2013) (0)
Endothelial cell-derived ET-1 contributes to the severity of septic kidney injury (2013) (0)
Endothelin and its signaling - Genetic analysis in mice (1997) (0)
-1234-IMPORTANCE OF ENDOTHELIN IN THE REGULATION OF HUMAN VASCULAR TONUS:STUDY IN THE RESISTANCE PORTION AND THE CONDUIT PORTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY (1990) (0)
Different Effects of orexin receptor antagonist and gabaa agonist on physical and cognitive functions after forced awakening (2019) (0)
Restoration of orexin signaling in the dorsal raphe and locus coeruleus differntially ameliorate symptoms of narcoleptic mice (2013) (0)
2P230 ヨーロッパモノアラガイの中枢神経系における神経活動の膜電位イメージング (II) Fluorescent Voltage Imaging of the Neural Activity in the Central Nervous System of the Pond Snail (II) (2014) (0)
Targeted lacking of ryanodine receptor type 2 in the heart suppresses pressure overload-induced hypertrophic responses but impairs cardiac functions (2002) (0)
Loss of Goosecoid-like and Dgcr14 in interpeduncular nucleus alters the expression of REM sleep (2010) (0)
OE-238 Inhibition of Vascular Endothelial Endothelin-1 Reduced Inflammatory Cells Recruitment and Neointimal Formation after Flow Cessation(Atherosclerosis, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society) (2007) (0)
PE-375 Endothelin-1 Partially Mediated Angiotensin II-induced hypertension, Cardiac Fibrosis and Body Weight Loss(Hypertension, Basic 4 (H) : PE64)(Poster Session (English)) (2004) (0)
Chapter V Orexin receptors (2002) (0)
Function of adult-born neurons in maturation of fear memory engram during sleep (2019) (0)
A postulated endothelin-1 autocrine loop in lung cancer (2000) (0)
Endothelin B Receptor (EDNRB) in Ovulation and Luteolysis. (2011) (0)
Vascular Remodeling After Injury Revealed by Endothelin-B Receptor Vascular Endothelin-B Receptor System In Vivo Plays a Favorable Inhibitory Role in (2002) (0)
Endothelin and atherosclerosis, a target for drug development (1994) (0)
Genetic or pharmacological ablation of orexin attenuated and supplementation ameliorated hypercapnic chemoreflex (2006) (0)
QRFP plays a critical role in regulating feeding behavior as a molecular link between the arcuate nucleus and nucleus accumbens (2011) (0)
Absence of ETA receptors on podocytes is not antialbuminuric in diabetic mice (2013) (0)
Abstract 5456: Vascular Endothelial Cells Endothelin-1 Deficiency Decreased Vascular Protection in Atherosclerosis Mouse Model (2008) (0)
A novel variant form of epidermal growth factor receptor (EGFR) protein in human lung cancer cell lines (2007) (0)
Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β. (2020) (0)
Orexin agonist improves inflammation-induced immobility (2018) (0)
Endothelin converting enzyme inhibition attenuates early albuminuria and late renal failure in streptozotocin induced diabetic mice (2013) (0)
Disecting behaviors from orphan GPCRs (2006) (0)
A step towards demystifying sleep physiology: Forward genetics approach in mice (2019) (0)
Role of hypothalamic orexin neurons in the regulation of arousal according to energy balance (2004) (0)
Gene therapy for Hirschsprung disease (1997) (0)
The human preproendothelin gene: Structure and possible regulation by endothelial PI-turnover signaling (1989) (0)
Transgenic Sprague Dawley rats with ataxin3-mediated destruction of orexin neurons display reduced tail artery Sympathetic Cutaneous Vasomotor Alerting Responses (SCVARs) (2013) (0)
Cloning and characterization of a novel endothelin receptor subtype in the avian class ( neural crest y development y melanocytes ) (1998) (0)
FRS-046 Genetic Inactivation of Vascular Endothelial Cell Endothelin-1 is Protective Against High-fat Diet Induced Obesity and Metabolic Syndrome(Progress in Preventive Medicine-1 (H) FRS10,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society) (2006) (0)
Emergence of clinical applications of endothelin system inhibitors. (2004) (0)
4) Genetics and Neuroscience of Sleep (2016) (0)
Analysis of phosphorylation state in new sleep regulatory gene Sleepy (2016) (0)
Transgenic rats with ataxin3-mediated destruction of orexin neurons have a diminished brown adipose tissue (BAT) thermogenic response to confrontation with an intruder rat (2013) (0)
and supplementation studies in mice evidence from genetic and pharmacological disruption Contribution of orexin in hypercapnic chemoreflex (2015) (0)
Title Forebrain Ptf 1 a Is Required for Sexual Differentiation of theBrain (2018) (0)
Neuronal firing in the cerebral cortex during waking and NREM sleep (2016) (0)
1P230 Synchronous activity of orexin neurons in the lateral hypothalamus(15. Neuroscience & Sensory systems,Poster) (2013) (0)
Classification : Medical Science Aromatic D-amino acids act as chemoattractant factors for human leukocytes through the G protein-coupled receptor GPR 109 B ( orphan GPCR / amino acid / leukocyte / chemoattractant / ) (2017) (0)
The Mechanism for hydralazine-induced endothelum-dependent relaxation in porcine coronary artery. (1993) (0)
Abstract 1321: Endothelial Cell-restricted Inactivation of Endothelin-1 Revealed Its Unexpected Role in the Regulation of Adipose Tissue Mass Accumulation Through its Angiogenic Property (2006) (0)
A SPLICING MUTATION OF ENDOTHELIN-B RECEPTOR GENE IN SPOTTING LETHAL RAT: A MODEL OF HIRSCHSPRUNG DISEASE (1995) (0)
Genetic Inactivation of Vascular Endothelial Endothelin-1 in Mice is Protective against Angiotensin II-induced Hypertension, Vascular Remodeling and Cardiac Fibrosis(The 69th Annual Scientific Meeting of the Japanese Circulation Society) (2005) (0)
Endothelin-DNA and to their use. (1989) (0)
Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation. Kumar et al. -1 (2020) (0)
The Journal of Comparative Neurology, Table of Content, Vol. 525, No. 18, December 15, 2017 (2017) (0)
Endothelin activates the inositol lipid signaling pathway in cultured vascular smooth muscle cells. (1989) (0)
Erratum: Contribution of endogenous endothelin-1 and endothelin-A receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice (Journal of Cardiovascular Pharmacology (2000) 36:5 suppl 1 (72-74)) (2001) (0)
Enteric neuroblast-specific expression of endothelin-b receptors allows normal ens development in the aganglionosis rat: 3 (1997) (0)
A Novel Rearrangement Reaction of Morphinan to Arylmorphan Skeletons and the Pharmacologies of Arylmorphan Derivatives (2019) (0)
and Wistar-Kyoto rats Characteristics of pressor response to endothelin in spontaneously hypertensive (2011) (0)
Long sleeer mouse as new type 2 diabetes model (2016) (0)
Induction of preproendothelin-1 mRNA by vasoactive hormones in cultured bovine endothelial cells (1990) (0)
Endothelial‐Derived ET‐1 Contributes to the Pressor Response Elicited by Acute Behavioral Stress (2016) (0)
Characteristics of bark-stripping of Hinoki cypress ( Chamaecyparis obtusa) trees by Japanese black bear ( Ursus thibetanus japonicus ) and development of wood decay (2016) (0)
1P294 Fiber-optic fluorescent imaging of neural activity in freely-moving mice during sleep and wakefulness(27. Bioimaging,Poster) (2013) (0)
Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton (2021) (0)
Nouveaux ligands du recepteur de neuropeptides HFGAN72 (1997) (0)
in Endothelin B Receptor Deficient Rats (2001) (0)
-0828-BIPHASIC RELEASE OF CARDIAC MYOSIN LIGHT CHAIN II IN PATIENTS OF ACUTE MYOCARDIAL INFARCTION WITH SUCCESSFUL RECANALIZATION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY (1990) (0)
32 ENDOTHELIN 1 DECREASES LUNG EDEMA CLEARANCE IN ALVEOLAR EPITHELIAL CELLS VIA ENDOTHELIAL ET-B RECEPTOR ACTIVATION AND NITRIC OXIDE GENERATION. (2007) (0)
Retraction Note to: Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy (2022) (0)
Effect of endothelin on isolated spinal cord of newborn rat (1989) (0)
Vascular endothelial cell-derived endothelin-1 mediates vascular inﬂammation and neointima formation following blood ﬂow cessation (2009) (0)
knockout mice chemoreflex and exaggerated sleep apnea in orexin Vigilance state-dependent attenuation of hypercapnic (2015) (0)
Lessons learned from the ligands of (previously) orphan GPCRs (2005) (0)
PJ-175 Endothelin Converting Enzyme-1 Heterozygous Mice Augment Ischemic Induced Angiogenesis Recovery in Streptozotocin Induced Type1 Diabetic Hindlimb Ischemia Model(Regeneration(angiogenesis/myocardial regeneration)(04)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes (2008) (0)
3P-0746 Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion (2003) (0)

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