Robin Franklin
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Most Influential Person Now
British stem cell biologist
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Biology
Robin Franklin's Degrees
- Bachelors Biochemistry University of Oxford
Why Is Robin Franklin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Robin Franklin, FRS is a British cell biologist and neuroscientist. He is currently a Principal Investigator at Altos Labs Cambridge Institute of Science having previously been Professor of Stem Cell Medicine at the Wellcome–MRC Cambridge Stem Cell Institute at the University of Cambridge. He is Emeritus Fellow of Pembroke College, Cambridge.
Robin Franklin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Remyelination in the CNS: from biology to therapy (2008) (1344)
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination (2013) (1290)
- Single‐Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell‐State Changes (2019) (1004)
- Debris clearance by microglia: an essential link between degeneration and regeneration (2008) (932)
- Why does remyelination fail in multiple sclerosis? (2002) (816)
- Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation (2006) (610)
- Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009) (569)
- CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. (2010) (560)
- Rejuvenation of regeneration in the aging central nervous system. (2012) (542)
- The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation (2002) (518)
- Retinoid X receptor gamma signaling accelerates CNS remyelination (2011) (440)
- Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells (1993) (424)
- Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency (2008) (422)
- bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS (2004) (415)
- Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis (2014) (403)
- Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System (2008) (353)
- Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin‐induced demyelination (2001) (344)
- Regenerating CNS myelin — from mechanisms to experimental medicines (2017) (341)
- Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination (2004) (324)
- Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination (2011) (317)
- Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression (2005) (316)
- Schwann cell‐like myelination following transplantation of an olfactory bulb‐ensheathing cell line into areas of demyelination in the adult CNS (1996) (314)
- Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti‐galactocerebroside: A comparative study (1999) (311)
- Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells (2009) (295)
- Myelin regeneration: a recapitulation of development? (2011) (288)
- Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS (2004) (288)
- Steroid hormones and neurosteroids in normal and pathological aging of the nervous system (2003) (285)
- Regulatory T cells promote myelin regeneration in the Central Nervous System (2017) (284)
- Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes (2000) (279)
- Neuronal vulnerability and multilineage diversity in multiple sclerosis (2019) (275)
- Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. (2000) (273)
- Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin‐induced CNS demyelination (1999) (271)
- Multiple sclerosis genetics (2014) (265)
- Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes (2013) (257)
- Remyelination in experimental models of toxin-induced demyelination. (2008) (250)
- Neuroprotection and repair in multiple sclerosis (2012) (243)
- Olig gene function in CNS development and disease (2006) (235)
- Niche stiffness underlies the aging of central nervous system progenitor cells (2019) (227)
- Distinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination (1999) (224)
- Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy. (2010) (218)
- Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors (2015) (218)
- Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than schwann cells following transplantation into adult cns white matter (2003) (202)
- Quantifying the Early Stages of Remyelination Following Cuprizone‐induced Demyelination (2003) (199)
- Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination (2011) (196)
- Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development (2007) (192)
- Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration (2015) (191)
- Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells (2019) (185)
- Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system (1997) (183)
- Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling (2009) (180)
- Overcoming remyelination failure in multiple sclerosis and other myelin disorders (2010) (179)
- Stem cell transplantation in multiple sclerosis: current status and future prospects (2010) (175)
- Fibronectin aggregation in multiple sclerosis lesions impairs remyelination. (2013) (172)
- Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells (2006) (170)
- Delayed Changes in Growth Factor Gene Expression during Slow Remyelination in the CNS of Aged Rats (2000) (162)
- Macrophages and CNS remyelination (2014) (162)
- Genome-wide meta-analysis, fine-mapping, and integrative prioritization implicate new Alzheimer’s disease risk genes (2021) (161)
- Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. (2004) (158)
- The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain (2004) (157)
- Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model (2012) (156)
- Glia Disease and Repair-Remyelination. (2015) (155)
- LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination (2017) (152)
- Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination (2005) (151)
- Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination (2006) (148)
- Requirements for schwann cell migration within cns environments: A viewpoint (1993) (147)
- Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination (2010) (146)
- Transplanted CG4 Cells (an Oligodendrocyte Progenitor Cell Line) Survive, Migrate, and Contribute to Repair of Areas of Demyelination in X-Irradiated and Damaged Spinal Cord but Not in Normal Spinal Cord (1996) (146)
- Olfactory Ensheathing Cells and CNS Regeneration The Sweet Smell of Success? (2000) (143)
- Auxetic nuclei in embryonic stem cells exiting pluripotency. (2014) (137)
- Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis. (2011) (137)
- Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage (2011) (136)
- Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. (2015) (135)
- The translational biology of remyelination: Past, present, and future (2014) (135)
- Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS (2006) (135)
- Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord (1991) (131)
- Superparamagnetic Iron Oxide-Labeled Schwann Cells and Olfactory Ensheathing Cells Can Be Traced In Vivo by Magnetic Resonance Imaging and Retain Functional Properties after Transplantation into the CNS (2004) (127)
- Systemic progesterone administration results in a partial reversal of the age‐associated decline in CNS remyelination following toxin‐induced demyelination in male rats (2004) (125)
- Expression of dominant-negative and chimeric subunits reveals an essential role for β1 integrin during myelination (2001) (124)
- Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression (2014) (122)
- Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system. (2003) (120)
- Understanding CNS remyelination: Clues from developmental and regeneration biology (1999) (118)
- Enhancing Central Nervous System Remyelination in Multiple Sclerosis (2005) (118)
- Glial-cell transplantation and plasticity in the O-2A lineage — implications for CNS repair (1995) (117)
- Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration (1997) (115)
- Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration (2020) (110)
- Transplantation of glial cells into the CNS (1991) (110)
- β1-Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination (2006) (110)
- Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation (2015) (107)
- Do olfactory glia have advantages over Schwann cells for CNS repair? (1997) (106)
- Differentiation of the O‐2A progenitor cell line CG‐4 into oligodendrocytes and astrocytes following transplantation into glia‐deficient areas of CNS white matter (1995) (105)
- Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy (2006) (104)
- Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline (2016) (104)
- The biology of CNS remyelination (2008) (101)
- Mechanical environment modulates biological properties of oligodendrocyte progenitor cells. (2012) (96)
- Cryopreserved Cells Isolated from the Adult Canine Olfactory Bulb Are Capable of Extensive Remyelination Following Transplantation into the Adult Rat CNS (2002) (94)
- Steroids and the reversal of age-associated changes in myelination and remyelination (2003) (93)
- Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia (2002) (89)
- Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. (2003) (89)
- Remyelination: the true regeneration of the central nervous system. (2013) (87)
- Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes (2010) (87)
- A map of transcriptional heterogeneity and regulatory variation in human microglia (2019) (86)
- Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination (2017) (85)
- Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury. (2005) (85)
- Schwann cell remyelination is restricted to astrocyte‐deficient areas after transplantation into demyelinated adult rat brain (2000) (85)
- Transplanting oligodendrocyte progenitors into the adult CNS (1997) (84)
- Schwann Cells Transplanted into Normal and X-Irradiated Adult White Matter Do Not Migrate Extensively and Show Poor Long-Term Survival (2000) (82)
- Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma. (2009) (81)
- The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury (2015) (80)
- Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS (2006) (79)
- Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins (2004) (78)
- High Yields of Oligodendrocyte Lineage Cells from Human Embryonic Stem Cells at Physiological Oxygen Tensions for Evaluation of Translational Biology (2013) (78)
- Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain. (1999) (77)
- Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects (2010) (77)
- Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin (2016) (77)
- Remyelination by transplanted olfactory ensheathing cells. (2003) (75)
- Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. (2016) (75)
- Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. (2013) (75)
- Up‐regulation of oligodendrocyte precursor cell αV integrin and its extracellular ligands during central nervous system remyelination (2009) (73)
- Homologous protein domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that MMR vaccine might provide protection against COVID-19 (2020) (72)
- Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System. (2007) (72)
- Mechanisms of CNS remyelination—the key to therapeutic advances (2005) (71)
- Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain (2022) (71)
- Axon loss in multiple sclerosis (1998) (68)
- Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination. (2016) (68)
- Robust Regeneration of CNS Axons through a Track Depleted of CNS Glia (2000) (67)
- Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology (2007) (65)
- Oligodendrocyte progenitors: Adult stem cells of the central nervous system? (2014) (65)
- Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system (2006) (65)
- Myelination and behaviour of tenascin‐C null transgenic mice (1999) (64)
- Stem cells, progenitors and myelin repair (2005) (64)
- Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin. (2020) (62)
- The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain (2000) (62)
- Temporal dynamics of myelination in the zebrafish spinal cord (2010) (62)
- Ageing and CNS remyelination (2002) (62)
- An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss (2008) (62)
- Transplantation Options for Therapeutic Central Nervous System Remyelination (2000) (62)
- Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity (2018) (62)
- Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury (2018) (61)
- Zebrafish myelination: a transparent model for remyelination? (2008) (61)
- Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity? (2019) (61)
- In vitro and In vivo Analysis of a Rat Bipotential O – 2A Progenitor Cell Line Containing the Temperature‐sensitive Mutant Gene of the SV40 Large T Antigen (1993) (60)
- Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination (2015) (59)
- Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system (2020) (58)
- Remyelination — An effective means of neuroprotection (2010) (56)
- Myelin repair: the role of stem and precursor cells in multiple sclerosis (2008) (56)
- Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen (2011) (55)
- MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter (2016) (55)
- Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation. (2019) (55)
- Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system (2013) (54)
- Growth factors and remyelination in the CNS. (1997) (53)
- Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression (2017) (53)
- Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS (2001) (53)
- Recognition and diagnosis of lysosomal storage diseases in the cat and dog. (2002) (52)
- Increasing Local Levels of IGF-I mRNA Expression Using Adenoviral Vectors Does Not Alter Oligodendrocyte Remyelination in the CNS of Aged Rats (2002) (52)
- To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions? (1997) (52)
- Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis (2007) (52)
- The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals (1992) (52)
- Remyelination and ageing: Reversing the ravages of time (2019) (50)
- Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells (2011) (49)
- Increasing local levels of neuregulin (glial growth factor‐2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS (2003) (48)
- Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination. (2015) (47)
- Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS (1995) (47)
- The EIIIA domain from astrocyte‐derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination (2014) (47)
- Brain pericyte plasticity as a potential drug target in CNS repair. (2013) (47)
- Taking ageing into account in remyelination-based therapies for multiple sclerosis (2008) (47)
- Fibroblast growth factor signaling in oligodendrocyte‐lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions (2015) (47)
- Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination (2013) (46)
- Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation (2011) (44)
- Expression of the POU-Domain Transcription Factors SCIP/Oct-6 and Brn-2 Is Associated with Schwann Cell but Not Oligodendrocyte Remyelination of the CNS (2002) (44)
- CNS Remyelination and the Innate Immune System (2016) (43)
- The phagocytic capacity of neurones (2007) (43)
- Profilin 1 is required for peripheral nervous system myelination (2014) (43)
- Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination (2008) (43)
- SCIP/Oct‐6, Krox‐20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells (2001) (41)
- Transplant mediated repair of the central nervous system: an imminent solution? (2002) (41)
- Type 1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage. (1992) (41)
- The effects of the growth factor‐antagonist, trapidil, on remyelination in the CNS (1997) (41)
- Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. (2012) (37)
- Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination (2015) (37)
- The role of astrocytes in the remyelination of glia-free areas of demyelination. (1993) (37)
- Efficient Remyelination Requires DNA Methylation (2017) (37)
- The reconstruction of an astrocytic environment in glia-deficient areas of white matter (1993) (36)
- Transplantation options for therapeutic central nervous system remyelination. (2000) (36)
- Endogeneous remyelination: findings in human studies. (2012) (35)
- Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice (2017) (35)
- Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres (2006) (35)
- The Mysteries of Myelin Unwrapped (2004) (35)
- Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system (2007) (35)
- CNS axons retain their competence for myelination throughout life (2004) (33)
- Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis (2020) (33)
- Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy (2016) (32)
- SpL201: A conditionally immortalized Schwann cell precursor line that generates myelin (2001) (32)
- Lentiviral vectors for gene delivery to normal and demyelinated white matter (2003) (32)
- Quantification of deficits in lateral paw positioning after spinal cord injury in dogs (2008) (32)
- What roles do growth factors play in CNS remyelination? (2001) (32)
- Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing (2020) (32)
- Dyskinesia in an adult bichon frise. (2001) (31)
- Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors (2019) (30)
- Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes (2015) (29)
- Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures. (2006) (29)
- The Role of Astrocytes in Remyelination (2020) (29)
- Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: Defining cellular targets (2008) (29)
- Lesion-Induced Accumulation of Platelets Promotes Survival of Adult Neural Stem / Progenitor Cells (2015) (29)
- A movement disorder in boxer pups (1999) (28)
- The Use of Transplanted Glial Cells to Reconstruct Glial Environments in the CNS (1995) (27)
- SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke (2019) (27)
- Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells (2007) (27)
- Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis (2013) (26)
- Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat (2010) (26)
- Adenoviral vectors for in vivo gene delivery to oligodendrocytes: transgene expression and cytopathic consequences (1999) (26)
- Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study (2021) (25)
- Cell Therapy for Spinal Cord Injuries (2014) (24)
- Obtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS? (2002) (24)
- Current status of myelin replacement therapies in multiple sclerosis. (2012) (23)
- Progressive encephalomyelopathy and cerebellar degeneration in 10 captive-bred cheetahs (2001) (23)
- Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans (2020) (22)
- SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells. (2002) (22)
- The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination (2019) (22)
- Myokymia and neuromyotonia in veterinary medicine: a comparison with peripheral nerve hyperexcitability syndrome in humans. (2013) (22)
- Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells (2018) (22)
- The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche☆ (2013) (22)
- Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination (2019) (21)
- Neuroaxonal dystrophy in a litter of papillon pups. (1995) (21)
- GM1-gangliosidosis in a cross-bred dog confirmed by detection of GM1-ganglioside using electrospray ionisation-tandem mass spectrometry (2000) (21)
- Reconstructing myelin-deficient environments in the CNS by glial cell transplantation (1993) (21)
- The expression of myelin basic protein exon 1 and exon 2 containing transcripts during myelination of the neonatal rat spinal cord<197>an in situ hybridization study (1998) (21)
- Sensory neuropathy in a Jack Russell terrier (1992) (20)
- Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models. (2015) (20)
- The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination (2001) (20)
- Remyelinating the demyelinated CNS. (2000) (20)
- Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence (2021) (20)
- Neural Precursor Cells Cultured at Physiologically Relevant Oxygen Tensions Have a Survival Advantage Following Transplantation (2013) (19)
- Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination (1998) (19)
- Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain. (2014) (19)
- Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia. (2005) (19)
- Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS (2006) (19)
- Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis. (2020) (18)
- A new form of ovine GM1-gangliosidosis (2004) (18)
- Remyelination in demyelinating disease. (1997) (18)
- Regenerative Medicines for Remyelination: From Aspiration to Reality. (2015) (18)
- Peroxisome proliferator‐activated receptor gamma‐coactivator‐1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis (2013) (18)
- Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation (2015) (17)
- The behaviour of meningeal cells following glial cell transplantation into chemically‐induced areas of demyelination in the CNS (1992) (17)
- Serum-Free Medium Provides a Clinically Relevant Method to Increase Olfactory Ensheathing Cell Numbers in Olfactory Mucosa Cell Culture (2007) (17)
- Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z. (2012) (17)
- Toxin-Based Models to Investigate Demyelination and Remyelination. (2019) (17)
- The peripheral nervous system--central nervous system regeneration dichotomy: a role for glial cell transplantation. (1990) (16)
- Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity? (2021) (16)
- Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells (2019) (16)
- Embryonic-Derived Olfactory Ensheathing Cells Remyelinate Focal Areas of Spinal Cord Demyelination more Efficiently than Neonatal or Adult-Derived Cells (2013) (16)
- Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits? (2021) (15)
- Central core myopathy in a great dane (1994) (15)
- A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System (2018) (15)
- Electric Signals Regulate the Directional Migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin (2016) (15)
- Remyelination by Endogenous Glia (2004) (15)
- Neuroscience. The mysteries of myelin unwrapped. (2004) (14)
- Transplantation of glial cell cultures into areas of demyelination in the adult CNS. (1990) (14)
- Reconstruction of the glia limitans by sub‐arachnoid transplantation of astrocyte‐enriched cultures (1995) (14)
- Effects of pre- versus post-anaesthetic buprenorphine on propofol-anaesthetized rats. (2005) (14)
- Glial cell transplantation and the repair of demyelinating lesions (1997) (13)
- Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease. (2017) (13)
- Stem cell treatments and multiple sclerosis (2010) (13)
- Remyelination in the CNS of the hypothyroid rat. (1996) (12)
- The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination (2020) (12)
- Review : Remyelination—A Regenerative Process in the CNS (1999) (12)
- Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat (2010) (11)
- Acute but not inherited demyelination in mouse models leads to brain tissue stiffness changes (2018) (11)
- Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat (2011) (11)
- Histological diagnosis of mucopolysaccharidosis IIIA in a wire-haired dachshund (2001) (11)
- Niche stiffness underlies the ageing of central nervous system progenitor cells (2019) (11)
- An inherited neurological disorder of the St Bernard dog characterised by unusual cerebellar cortical dysplasia (1997) (10)
- Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs. (2007) (10)
- The VF rat with abnormal myelinogenesis has a mutation in Dopey1 (2014) (10)
- Bridging the divide: spinal cord repair by cellular transplantation--from research laboratory to therapeutic application. (2001) (10)
- Cellular responses in the spinal cord during development of hypomyelination in the mv rat (2008) (10)
- Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination (2020) (9)
- Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain (2018) (9)
- Myelin Repair and Neuroprotection in Multiple Sclerosis (2013) (9)
- Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis (2011) (9)
- Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders. (2019) (8)
- Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures (2008) (7)
- Do your glial cells make you clever? (2013) (7)
- Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing. (2020) (7)
- Tyrosine kinases: maiming myelin in leprosy (2006) (7)
- Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture. (2008) (6)
- The Brown Animal Sanatory Institution--historical lessons for the present? (2000) (6)
- CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities (2022) (6)
- Author Correction: Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes (2021) (6)
- Endogenous Remyelination in the CNS (2013) (6)
- Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells (2019) (6)
- Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor (2012) (6)
- Clinical implications of myelin regeneration in the central nervous system (2018) (5)
- Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence (2019) (5)
- Repair of demyelinated lesions by glial cell transplantation (1994) (5)
- The spontaneous regeneration of myelin : an unexpected central role of the androgen receptor (2017) (5)
- Recent Insights into the Cellular Biology of Remyelination (1997) (5)
- Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent (2022) (5)
- The age‐related decrease in CNS remyelination efficiency is caused by an impairment of both oligodendrocyte progenitor recruitment and differentiation (2002) (5)
- The Transplantation of Glial Cells into Areas of Primary Demyelination (1990) (5)
- Myc determines the functional age state of oligodendrocyte progenitor cells (2021) (5)
- FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures. (2010) (4)
- Ageing and multiple sclerosis (2022) (4)
- Use of the forced oscillating airflow technique to measure the resistance of the equine upper airway: effects of laryngoventriculectomy and laryngoplasty. (1990) (4)
- Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke (2021) (4)
- Transplanting myelin-forming cells into the central nervous system: principles and practice. (1998) (3)
- Repairing CNS Demyelination by Glial Cell Transplantation (1997) (3)
- Hereditary ataxia, myokymia and neuromyotonia in Jack Russell terriers (2012) (3)
- Differences in their interactions with astrocytes distinguish the behaviour of olfactory ensheathing cells and Schwann cells (2002) (2)
- Remyelination of regenerating axons (2017) (2)
- The electron microscopic appearance of the beta-galactosidase reaction product. (1991) (2)
- Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system (2020) (2)
- Endogenous opioids and slaughter-induced stress (1986) (2)
- Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis (2022) (2)
- [Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells]. (2007) (2)
- Transplanting Myelinogenic Cells into the CNS (2000) (1)
- Correction: Zhao et al., “Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination” (2017) (1)
- Multiple Sclerosis: The adult human oligodendrocyte precursor cell: a key player in myelin repair (2010) (1)
- Seeing is believing: Identifying remyelination in the central nervous system. (2022) (1)
- Specific oligodendrocyte populations have differential spatial distribution and susceptibility to injury (2019) (1)
- Intravitreal Transplantation of Oligodendrocyte Precursor Cells Increases Retinal Ganglion Cell Survival in a Rat Glaucoma Model (2008) (1)
- Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats (2021) (1)
- Do Not Adjust Your Mind: The Fault Is in Your Glia. (2017) (1)
- The electron microscopic appearance of the β-galactosidase reaction product (1991) (1)
- Using Naturally Occurring Spinal Cord Injury in Domestic Dogs to Explore Novel Therapeutic Options (2013) (1)
- Neural Stem Cells and Demyelinating Disease (2015) (1)
- Author response: Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells (2018) (1)
- GREY MATTER ASTROCYTES ACTIVATED BY REMOTE AXONAL TRANSECTION MEDIATE STRUCTURAL PLASTICITY (2013) (0)
- A Role for Notch Signalling in Remyelination of the Central Nervous System (2003) (0)
- Remyelination varies between and within lesions in multiple sclerosis following bexarotene (2022) (0)
- Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy (2016) (0)
- Pioglitazone treatment enhances myelin debris phagocytosis and immunoregulatory functions of monocytes from MS patients (P1.162) (2015) (0)
- OPC heterogeneity in the optic nerve (2015) (0)
- Charles Dickens, The Royal Veterinary College and the veterinary profession. (1997) (0)
- A retroviral origin of vertebrate myelin (2022) (0)
- RXR-VDR signaling regulates oligodendrocyte precursor cell differentiation (2015) (0)
- SPONTANEOUSLY ARISING DISEASE: REVIEW ARTICLE Remyelination: The True Regeneration of the Central Nervous System (2013) (0)
- Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination (2016) (0)
- Remyelination of the Central Nervous System (2007) (0)
- The biology of the transplanted oligodendrocyte progenitor (1997) (0)
- RETINOIC ACID RECEPTOR SIGNALLING PROMOTES CNS REMYELINATION (2009) (0)
- Regulatory T cells promote CNS myelin regeneration in vivo (2014) (0)
- In vitro evaluation of GPR17 radioligands as potential CNS stem cell imaging agents (2021) (0)
- Special Issue on Stem Cells: “The End of the Beginning” (2014) (0)
- FUNCTIONAL HUMAN ES-DERIVED OPCS AT LOW OXYGEN (2014) (0)
- REDUCTION OF FIBRONECTIN EXPRESSION DECREASES OLIGODENDROCYTE LINEAGE CELL NUMBERS IN DEMYELINATION, BUT DOES NOT IMPAIR CNS REMYELINATION (2011) (0)
- Mitochondrial dysfunction and remyelination failure (2011) (0)
- Ela Foundation Organization Chart Board of Trustees Scientific Committee Steering Committee Table of Contents (0)
- Potential treatment for canine spinal cord injury. (2003) (0)
- IDENTIFICATION OF INFLAMMATORY FACTORS THAT PROMOTE MYELINATION (2009) (0)
- Transplantation of Myelin-Forming Cells (2004) (0)
- The proteome of remyelination is different from that of developmental myelination (2021) (0)
- The role of complex IV activity in the axonal response of mitochondria to demyelination in experimental disease models of multiple sclerosis (2021) (0)
- Remyelination in germ-free mice (2017) (0)
- Cell-free DNA-based liquid biopsies in neurology (2022) (0)
- FIBRONECTIN IN REMYELINATION (2009) (0)
- Glial aging and its impact on central nervous system myelin regeneration (2022) (0)
- SARM1 detection in oligodendrocytes but not Schwann cells though sarm1/Sarm1 deletion does not perturb CNS nor PNS myelination in zebrafish and mice (2022) (0)
- Oligodendrocyte-encoded Kir4.1 function is required for integrity. (2018) (0)
- SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice (2023) (0)
- Edinburgh Research Explorer Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development (2018) (0)
- Pericytes promote the generation of oligodendrocytes during remyelination (2017) (0)
- Aging Myelin and Cognitive Decline: a Role for Steroids (2004) (0)
- P22: In vitro characterization and assessment of differentiation potential of adult rat olfactory neuroepithelium derived neural stem cells (2004) (0)
- Changes in Mechanical Properties Occur During Differentiation Within the Oligodendrocyte Lineage (2011) (0)
- CNS-pericytes promote oligodendrocyte fate decision and differentiation contributing to myelin development and repair (2015) (0)
- Single-Cell RNA Sequencin g of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes Graphical (0)
- Edinburgh Explorer Myelin regeneration in multiple sclerosis (2011) (0)
- as regulatory therapeutic target in newborn brain injury and remyelination. (2016) (0)
- FIBRONECTIN IN REMYELINATION: DO ASTROCYTES SECRETE PATHOLOGICAL MULTIMERS IN MULTIPLE SCLEROSIS? (2009) (0)
- Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells (2019) (0)
- UK researchers win canine health awards (2014) (0)
- vulnerability and multilineage diversity in multiple sclerosis. (2019) (0)
- Cell therapy clinical trial for dogs with chronic spinal cord injury (2010) (0)
- Financial Support: M.C. acknowledges fellowship awards from the American Heart Association and The Children’s Heart Foundation and funding support from a Career Development Grant awarded by Cerebral Palsy (2021) (0)
- Effects of Macrophages and Monocytes in Remyelination of the CNS (2015) (0)
- Stem cell treatments and multiple sclerosis Benefit through immunosuppression is realistic , but regeneration is more difficult (0)
- Congenital Unilateral Absence of the Corticospinal Tract in a Siamese Cat (2007) (0)
- Differentiation, Migration, Proliferation, and Survival of Oligodendrocyte Precursor Cells is Modulated by Mechanical Properties of their Environment (2012) (0)
- The role of OPC developmental heterogeneity in remyelination (2015) (0)
- Upregulation of non-canonical and canonical inflammasome genes associates with pathological features in Krabbe disease and related disorders (2022) (0)
- Neurological and urological condition in young boxer dogs. (1999) (0)
- The neuroprotective effects of Sonic hedgehog pathway agonist SAG in a rat model of neonatal stroke (2021) (0)
- Supplemental Information Rejuvenation of Regeneration in the Aging Central Nervous System (2011) (0)
- Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination (2016) (0)
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