Susumu Tonegawa | Academic Influence

Why Is Susumu Tonegawa Influential?

According to Wikipedia, is a Japanese scientist who was the sole recipient of the Nobel Prize for Physiology or Medicine in 1987, for his discovery of the genetic mechanism that produces antibody diversity. Although he won the Nobel Prize for his work in immunology, Tonegawa is a molecular biologist by training and he again changed fields following his Nobel Prize win; he now studies neuroscience, examining the molecular, cellular and neuronal basis of memory formation and retrieval.

Susumu Tonegawa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

RAG-1-deficient mice have no mature B and T lymphocytes (2713)
Somatic generation of antibody diversity (2309)
Somatic generation of antibody diversity. (1776)
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory (1706)
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. (1419)
Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. (1313)
Reduced stress defense in heme oxygenase 1-deficient cells. (1235)
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain (1130)
BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex (1128)
Optogenetic stimulation of a hippocampal engram activates fear memory recall (1085)
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages (1033)
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall (1033)
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene (1005)
Heme oxygenase 1 is required for mammalian iron reutilization. (969)
Skeletal and CNS Defects in Presenilin-1-Deficient Mice (954)
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice (880)
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network (838)
Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory (815)
Gamma/delta cells. (798)
Evidence for a differential avidity model of T cell selection in the thymus (739)
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice (723)
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells (703)
Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion (700)
Sequences at the somatic recombination sites of immunoglobulin light-chain genes (683)
Ordered rearrangement of immunoglobulin heavy chain variable region segments. (681)
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. (671)
Creating a False Memory in the Hippocampus (645)
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. (638)
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes (631)
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. (628)
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences (610)
Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice (606)
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice (570)
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice (569)
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval (557)
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity (553)
NMDA receptors, place cells and hippocampal spatial memory (552)
Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining (534)
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes (499)
PKCγ mutant mice exhibit mild deficits in spatial and contextual learning (498)
Engrams and circuits crucial for systems consolidation of a memory (490)
Modified hippocampal long-term potentiation in PKCγ-mutant mice (487)
Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia (487)
Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory (482)
Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses (476)
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex (475)
Developmental regulation of T-cell receptor gene expression (474)
Preplay of future place cell sequences by hippocampal cellular assemblies (471)
Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease (468)
Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background (467)
NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex (465)
Hippocampal CA3 NMDA Receptors Are Crucial for Memory Acquisition of One-Time Experience (464)
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes (463)
Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice (459)
Altered peptidase and viral-specific T cell response in LMP2 mutant mice. (454)
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia (453)
Bcl-2 promotes regeneration of severed axons in mammalian CNS (448)
Epigenetic regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in culture. (446)
Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning (442)
Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen (410)
Sequences of mouse immunoglobulin light chain genes before and after somatic changes (401)
Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice (380)
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes (375)
Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells (368)
Impaired synapse elimination during cerebellar development in PKCγ mutant mice (365)
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective (356)
Structure, organization, and somatic rearrangement of T cell gamma genes (344)
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments (339)
Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice (337)
Engram cells retain memory under retrograde amnesia (334)
Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. (331)
Bidirectional switch of the valence associated with a hippocampal contextual memory engram (327)
Dopamine D3 Receptor Mutant Mice Exhibit Increased Behavioral Sensitivity to Concurrent Stimulation of D1 and D2 Receptors (326)
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. (325)
A clustered plasticity model of long-term memory engrams (320)
Memory Engram Cells Have Come of Age (318)
Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons (318)
Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. (317)
Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects (309)
Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease (301)
Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons (300)
Ventral CA1 neurons store social memory (296)
Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. (296)
The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP (287)
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes (286)
Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice (283)
Persistent Multiple Climbing Fiber Innervationof Cerebellar Purkinje Cellsin Mice Lacking mGluR1 (282)
Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. (281)
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus (278)
Entorhinal Cortex Layer III Input to the Hippocampus Is Crucial for Temporal Association Memory (275)
An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory (270)
Successful Execution of Working Memory Linked to Synchronized High-Frequency Gamma Oscillations (265)
Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. (264)
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice (263)
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes (262)
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments (258)
Enhancement of Learning and Memory by Elevating Brain Magnesium (257)
A differential-avidity model for T-cell selection. (256)
Cell type-specific genetic and optogenetic tools reveal novel hippocampal CA2 circuits (254)
Memory engram storage and retrieval (248)
Alterations in Dopamine Release But Not Dopamine Autoreceptor Function in Dopamine D3 Receptor Mutant Mice (242)
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization (242)
Cell-type-specific contacts to immunoglobulin enhancers in nuclei (242)
Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. (241)
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit (239)
Activating positive memory engrams suppresses depression-like behaviour (237)
What is memory? The present state of the engram (233)
Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory (233)
Island Cells Control Temporal Association Memory (231)
Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice (230)
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors (228)
Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease (227)
Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. (226)
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus (223)
Recognition of the product of a novel MHC TL region gene (27b) by a mouse γδ T cell receptor (218)
In Vivo Two-Photon Imaging Reveals a Role of Arc in Enhancing Orientation Specificity in Visual Cortex (211)
Monoclonal antibodies specific to native murine T-cell receptor gamma delta: analysis of gamma delta T cells during thymic ontogeny and in peripheral lymphoid organs. (211)
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes (209)
Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator (209)
t Brain-Derived Neurotrophic Factor Overexpression Induces Precocious Critical Period in Mouse Visual Cortex (208)
Antagonistic negative and positive neurons of the basolateral amygdala (204)
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. (201)
Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. (199)
Dopamine D2 Long Receptor-Deficient Mice Display Alterations in Striatum-Dependent Functions (197)
Memory engrams: Recalling the past and imagining the future (196)
Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes (195)
CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage (190)
Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice. (187)
Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. (185)
The role of engram cells in the systems consolidation of memory (183)
Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF (183)
Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice (181)
Unusual organization and diversity of T-cell receptor a-chain genes (180)
NMDA Receptor-Dependent Refinement of Somatotopic Maps (179)
A complete immunoglobulin gene is created by somatic recombination (178)
gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses (178)
Brain‐derived neurotrophic factor over‐expression in the forebrain ameliorates Huntington’s disease phenotypes in mice (177)
Immunobiology of Murine T Cruzi Infection: The Predominance of Parasite‐nonspecific Responses and the Activation of TCRIT Cells (175)
The role of calcium–calmodulin kinase II in three forms of synaptic plasticity (175)
Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice (168)
Limited diversity of the rearranged T-cell γ gene (167)
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486 (166)
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. (164)
Lack of Self-Administration of Cocaine in Dopamine D1 Receptor Knock-Out Mice (163)
CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice (161)
Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart. (160)
Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories (159)
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes. (159)
Immunoglobulin gene rearrangement in immature B cells. (154)
Distinct preplay of multiple novel spatial experiences in the rat (153)
Modification of NMDA Receptor Channels and Synaptic Transmission by Targeted Disruption of the NR2C Gene (145)
Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors. (145)
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning. (144)
Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development. (144)
Activation of the c-myc gene by translocation: a model for translational control. (143)
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia (141)
Modified hippocampal long-term potentiation in PKC gamma-mutant mice. (138)
T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. (136)
Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. (136)
Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains. (132)
Ontogenic development and tissue distribution of V gamma 1-expressing gamma/delta T lymphocytes in normal mice (123)
Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis Bacillus Calmette Guérin: studies with T cell receptor‐deficient mutant mice (120)
Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context (119)
Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. (118)
Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice (117)
Synaptic plasticity, place cells and spatial memory: study with second generation knockouts (116)
Transcription of mouse kappa chain genes: implications for allelic exclusion. (116)
T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. (114)
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system (112)
Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells (112)
Exon shuffling generates an immunoglobulin heavy chain gene. (112)
Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex. (111)
Impaired Sequential Egocentric and Allocentric Memories in Forebrain-Specific–NMDA Receptor Knock-Out Mice during a New Task Dissociating Strategies of Navigation (110)
Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. (110)
Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells (110)
Hippocampal lesions impair contextual fear conditioning in two strains of mice. (109)
Somatic changes in the content and context of immunoglobulin genes. (107)
Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. (106)
Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory (106)
Cloning of an immunoglobulin variable region gene from mouse embryo. (105)
Dopamine D3 receptor mutant and wild‐type mice exhibit identical responses to putative D3 receptor‐selective agonists and antagonists (104)
Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2 (104)
TAP1‐independent loading of class I molecules by exogenous viral proteins (103)
Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity. (101)
Altered natural killer cell repertoire in Tap-1 mutant mice. (101)
CA1-specific N-methyl-d-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task (100)
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains (99)
Direct excitation of parvalbumin‐positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition (99)
Neural tube defects and abnormal brain development in F52-deficient mice. (98)
Organization of four mouse lambda light chain immunoglobulin genes. (97)
A Role for Calcium-Permeable AMPA Receptors in Synaptic Plasticity and Learning (96)
Evidence for somatic generation of antibody diversity. (95)
Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity (94)
Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background. (93)
Genetic neuroscience of mammalian learning and memory. (93)
Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent. (93)
The molecules of the immune system. (92)
Impaired Hippocampal Ripple-Associated Replay in a Mouse Model of Schizophrenia (92)
Cell type-specific enhancer element associated with a mouse MHC gene, Eβ (92)
Engram Cell Excitability State Determines the Efficacy of Memory Retrieval (91)
Activation of a translocated c-myc gene: role of structural alterations in the upstream region. (91)
Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits (90)
Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. (90)
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism. (89)
CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. (89)
Essential function of α-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse (88)
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining. (87)
T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression. (85)
CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice. (83)
Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay (82)
Self-tolerance to transgenic γδ T cells by intrathymic inactivation (80)
Blockade of transgenic gamma delta T cell development in beta 2‐microglobulin deficient mice. (80)
Tolerance Induction and Autoimmune Encephalomyelitis Amelioration After Administration of Myelin Basic Protein–derived Peptide (79)
Cell type-specific genetic and optogenetic tools reveal novel hippocampal CA 2 circuits (77)
Inception of a false memory by optogenetic manipulation of a hippocampal memory engram (77)
Impaired Spatial Learning in L-Calcium-Calmodulin Kinase Mutant Mice (75)
Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection. (74)
gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. (73)
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes. (71)
Entorhinal-hippocampal neuronal circuits bridge temporally discontiguous events. (71)
Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains. (70)
Transcription of the SV40 Genome in Transformed Cells and during Lytic Infection (69)
Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein (69)
Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory (69)
Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. (69)
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. (69)
Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer (68)
Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. (68)
Identification and optogenetic manipulation of memory engrams in the hippocampus (65)
Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. (64)
Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. (63)
Blockage of αβ T-cell development by TCR γδ transgenes (63)
T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets. (62)
DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats. (62)
Silent memory engrams as the basis for retrograde amnesia (61)
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. (60)
CA3 NMDA receptors are required for the rapid formation of a salient contextual representation (59)
Surface expression of alternative forms of the TCR/CD3 complex. (59)
Selection of preconfigured cell assemblies for representation of novel spatial experiences (58)
Hippocampal CA3 NMDA Receptors Are Crucial for Adaptive Timing of Trace Eyeblink Conditioned Response (58)
Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants (57)
Recognition of MHC TL Gene Products by γδ T Cells (57)
A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes (57)
Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment. (56)
Control of CA3 Output by Feedforward Inhibition Despite Developmental Changes in the Excitation–Inhibition Balance (56)
Development and selection of γδ T cells (55)
Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. (53)
CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. (53)
Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. (53)
Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABAB receptors (53)
Regulation of T-cell receptor gene expression in human T-cell development. (52)
Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. (50)
Expression of the T-cell receptor gamma-chain gene products on the surface of peripheral T cells and T-cell blasts generated by allogeneic mixed lymphocyte reaction. (50)
Development of schemas revealed by prior experience and NMDA receptor knock-out (49)
Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCR alpha mutant mice with inflammatory bowel disease. (49)
Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection. (49)
Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus (48)
Amygdala Reward Neurons Form and Store Fear Extinction Memory (47)
alpha beta and gamma delta T cells in the immune response to the erythrocytic stages of malaria in mice. (46)
Hippocampal neurons represent events as transferable units of experience (46)
The human T-cell receptor α-chain gene maps to chromosome 14 (45)
Acceleration of visually cued conditioned fear through the auditory pathway (44)
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements. (44)
Diversity, Development, Ligands, and Probable Functions of γδ T Cells (44)
Electrophoretically homogeneous myeloma light chain mRNA and its translation in vitro. (42)
Intermediates in the assembly of φX174 (41)
Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. (41)
Organization of immunoglobulin genes. (41)
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes. (40)
Differential reactivity of residual CD8+ T lymphocytes in TAP1 and β2‐microglobulin mutant mice (39)
Tap‐1変異マウスにおける自己およびアロ反応性CD8+T細胞の正の選択 (38)
NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. (38)
Positive selection of γδ T cells (38)
RAG-l-Deficient Mice Have No Mature 8 and T Lymphocytes (38)
Ontogenic Development and Tissue Distribution of V-yl-expressing y / b T Lymphocytes in Normal Mice (38)
Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guérin: studies with T cell receptor-deficient mutant mice. (37)
Why do mature CNS neurons of mammals fail to re-establish connections following injury–functions of Bcl-2 (35)
Restricted association of V and J-C gene segments for mouse lambda chains. (33)
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene (32)
Somatic reorganization of immunoglobulin genes during lymphocyte differentiation. (32)
Domains of the TCR beta-chain required for early thymocyte development (32)
Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon (32)
On somatic recombination in the central nervous system of transgenic mice. (31)
Identification and Manipulation of Memory Engram Cells. (31)
Dynamics of Immunoglobulin Genes (31)
Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. (31)
Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain. (31)
Diversity, development, ligands, and probable functions of gamma delta T cells. (31)
Hippocampal Neurons Express a Calcineurin-Activated Adenylyl Cyclase (30)
Somatic generation of immune diversity (30)
Spatial exploration is required for the formation of contextual fear memory. (30)
Deficient Hippocampal Long-Term Potentiation in oCa cium-Calmodulin Kinase Mutant Mice (30)
Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. (28)
The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. (28)
Amygdala Reward Neurons Form and Store Fear Extinction Memory (28)
PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ (27)
Expression of αv and β3 integrin chains on murine lymphocytes (26)
Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor. (26)
Brain-wide mapping of contextual fear memory engram ensembles supports the dispersed engram complex hypothesis (26)
The gene knockout technology for the analysis of learning and memory, and neural development. (26)
Role of protein kinase C family in the cerebellum‐dependent adaptive learning of horizontal optokinetic response eye movements in mice (26)
Somatic Generation of Immune Diversity (25)
Reiteration frequency of antibody genes Studies with κ‐chain mRNA (24)
Diversity of gamma delta T-cell receptors on murine intestinal intra-epithelial lymphocytes. (24)
Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response. (23)
CA3 NMDA receptors are required for experience‐dependent shifts in hippocampal activity (23)
Expression of cloned immunoglobulin genes introduced into mouse L cells. (22)
Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off (22)
Linkage of the four gamma subclass heavy chain genes. (22)
Antibody and T-cell receptors. (21)
Differentiation of forebrain and hippocampal dopamine 1‐class receptors, D1R and D5R, in spatial learning and memory (21)
Somatic generation of immune diversity (21)
Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development. (21)
Somatic Recombination and Structure of an Immunoglobulin Gene (21)
Hippocampal lesions impair contextual fear conditioning in two strains of mice. (20)
Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma (20)
Rearrangement and expression of Vγ1, Vγ2 and Vγ3 TCR γ genes in C57BL/6 mice (20)
Blockage of alpha beta T-cell development by TCR gamma delta transgenes. (20)
Phorbol ester effects at hippocampal synapses act independently of the gamma isoform of PKC. (19)
Functional and inducible expression of a transfected murine class II major histocompatibility complex gene. (19)
Lack of kainic acid‐induced gamma oscillations predicts subsequent CA1 excitotoxic cell death (19)
Optogenetics 3.0 (19)
Diversity, development, ligands, and probable functions of gamma delta T cells. (17)
The human T-cell receptor alpha-chain gene maps to chromosome 14. (16)
Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide. (16)
The beta 1 domain of the mouse E beta chain is important for restricted antigen presentation to helper T-cell hybridomas. (16)
Competition from newborn granule cells does not drive axonal retraction of silenced old granule cells in the adult hippocampus (15)
Hybridization studies with an antibody heavy chain mRNA (15)
Cloning and sequencing of murine T3 gamma cDNA from a subtractive cDNA library (14)
Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways (14)
Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory (13)
Mammalian Learning and Memory Studied by Gene Targeting (13)
Expression of alpha v and beta 3 integrin chains on murine lymphocytes. (12)
Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation. (12)
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. 1976 [classical article]. (11)
An unusual clonotypic determinant on a cytotoxic T lymphocyte line is encoded by an immunoglobulin heavy chain variable region gene. (11)
V and C parts of immunoglobulin κ-chain genes are separate in myeloma (11)
Limited diversity of the rearranged T-cell gamma gene. (11)
A Genetic Approach to Study Mechanisms of Cocaine Action a (10)
Rehebbilitating Memory (10)
Molecular Pathology and Novel Clinical Therapy for Uterine Leiomyosarcoma. (9)
Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma (9)
Cre/loxP recombination‐activated neuronal markers in mouse neocortex and hippocampus (9)
The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1987. Somatic generation of immune diversity. (9)
The Ins and Outs of Hippocampal Circuits (9)
Psychotomimetic effects of drugs--a common pathway to schizophrenia? (9)
Erratum: NMDA receptor-dependent ocular dominance plasticity in adult visual cortex (Neuron (June 19, 2003) 38 (977-985)) (8)
- CaMKII Mutant Mice α Hippocampal Slices from CA 1 Long-Term Potentiation Is Diminished but Present in (8)
Somatic recombination and mosaic structure of immunoglobulin genes. (8)
A novel diagnostic biomarker for human uterine leiomyosarcoma: PSMB9/β1i. (8)
Somatic Generation of Immune Diversity (Nobel Lecture) (8)
Science Over Politics (8)
Repertoire‐Determining Role of Peptide in the Positive Selection of CD8+ T cells (8)
Development and selection of gamma delta T cells. (8)
Revised nomenclature of mouseH-2 genes (8)
Gene targeting: a new approach for the analysis of mammalian memory and learning. (7)
A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor (7)
High-and low-affinity single-peptide y MHC ligands have distinct effects on the development of mucosal CD 8 aa and CD 8 ab T lymphocytes (7)
Thymic targets for Abelson murine leukemia virus are early gamma/delta T lymphocytes. (7)
CA1 pyramidal cells organize an episode by segmented and ordered events (7)
Cell type-specific enhancer element associated with a mouse MHC gene, E beta. (7)
Intermediates in the assembly of phi X174. (7)
Potential Biomarker for Human Uterine Leiomyosarcoma (6)
Proceedings: Determination of the number of antibody structural genes by DNA-RNA hybridization. (5)
Characterization of a mouse DNA clone containing an immunoglobulin variable region gene. (5)
Genetic transcription directed by the b2 region of lambda bacteriophage. (5)
A potential diagnostic biomarker: Proteasome LMP2/b1i-differential expression in human uterus neoplasm (5)
That great time in Basel (4)
Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice. (4)
Positive selection of gamma delta T cells. (4)
A diagnostic biomarker: differential expression of LMP2/β1i in human uterine neoplasms (4)
Molecular Approach to Uterine Leiomyosarcoma : LMP 2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma Citation (4)
Rehebbilitating Memory (3)
Picower Institute for Learning and Memory (3)
Tumor immunoediting, from T cell-mediated immune surveillance to tumor-escape of uterine leiomyosarcoma (3)
Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma (3)
Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors (3)
Spacial learning in mice (3)
GENETICS OF THE T-CELL RECEPTOR (3)
Manipulating memory in space and time (3)
The direction of in vitro genetic transcription on circular DNA. (2)
DNA clones containing mouse immunoglobulin K chain genes isolated by in vitro packaging into phage X coats ( somatic gene rearrangement / intron / Southern gel blotting / R loop mapping ) (2)
Restricted association of V and JC gene segments for mouse X light chains ( immunoglobulin / recombination / amino acid sequence variation / hybridoma / myeioma ) (2)
A functional gamma gene formed from known gamma-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes. (2)
In Search of Engram Cells (2)
[Molecular biology of immunologic recognition]. (2)
T gamma protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer. (2)
A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes. (2)
Tagging activated neurons with light (2)
NS-2 Limbic Epilepsy in α-Calcium-Calmodulin Kinase II Mutant Mice (2)
Expression of a v and b 3 integrin chains on murine lymphocytes (2)
Differentiation of Immunoglobulin Genes (2)
Amygdala Reward Neurons Form and Store Fear Extinction Memory (2)
39th Annual European Brain and Behaviour Society Abstracts (2)
The Proteasome Subunit LMP2/b1i In the Female Genital System (2)
Rearrangement and expression of Vzeta1, Vzeta2 and Vzeta3 TCR zeta genes in C57BL/6 mice. (2)
Nobel laureates' letter to President Bush. (2)
Topics in Integrative Neuroscience: On crucial roles of hippocampal NMDA receptors in acquisition and recall of associative memory (1)
Direct excitation of parvalbumin-positive interneurons by M 1 muscarinic acetylcholine receptors (1)
A molecular genetic approach to the pathogenesis of schizophrenia using genetically engineered mice (1)
Pillars article: High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994. 78: 399-408. (1)
Diagnostic Biomarker Candidates Including NT5DC2 for Human Uterine Mesenchymal Tumors (1)
PAK Inactivation Impairs Social Recognition in 3 xTg-AD Mice without Increasing Brain Deposition of Tau and A Citation (1)
Candidate molecules as diagnostic biomarker for human uterine mesenchymal tumors (1)
Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience Eilat, Israel, December 3–5, 2006 (1)
Deficient cerebellar long-term depression in metabotropic glutamate receptor-1 (mGluR1) mutant mice (1)
Cellular / Molecular Control of CA 3 Output by Feedforward Inhibition Despite Developmental Changes in the Excitation – Inhibition Balance (1)
Altered cortical spine morphology and impaired memory consolidation in forebrain-specific dominant negative p21-activated Kinase (PAK) transgenic mice (1)
Molecular and Circuit Mechanisms for Hippocampal Learning (1)
Spatial-Learning in Mutant Mice - Response (1)
ORGANIZATION AND EXPRESSION OF MOUSE λ LIGHT CHAIN IMMUNOGLOBULIN GENES (1)
Expression of the T-cell receptor y-chain gene products on the surface of peripheral T cells and T-cell blasts generated by allogeneic mixed lymphocyte reaction ( yS heterodimer / anti-y antibody / T-cell receptor ) (1)
Cingulate-motor circuits update rule representations for sequential choice decisions (0)
Author response: Development of schemas revealed by prior experience and NMDA receptor knock-out (0)
Monitoring and engineering memory engram cells and their circuits (0)
C-fos expression and accelerated visual cued fear conditioning in mice with visual input directed to the auditory thalamus (0)
Incorrect attribution of peptide source (0)
Newsmaker interview. Tonegawa rethinks Japan's premier brain research center. Interview by Dennis Normile. (0)
Atomic and Molecular Processes in Divertor Plasmas (0)
A potential diagnostic biomarker for human uterine mesenchymal tumor: proteasome LMP2/ β 1i subunit - differential expression (0)
Table of Contents (0)
Candidate Molecules and ki-67/MIB1 as Novel Diagnostic Biomarker for Human Uterine Mesenchymal Tumors (0)
203 Multiple climbing fiber innervation of cerebellar purkinje cells in metabotropic glutamate receptor-1 (mglur1) mutant mice (0)
Neuromodulation of Fast-Spiking Interneurons in Hippocampus-Dependent Learning and Epileptogenesis (0)
Pathobiology of Human Uterine Leiomyosarcoma for Development of Novel Diagnosis and Clinical Therapy (0)
TRANSGENIC MICE DEMONSTRATE THAT EPITHELIAL HOMING OF y / b T CELLS IS DETERMINED BY CELL LINEAGES INDEPENDENT OF T CELL RECEPTOR SPECIFICITY BY MARC BONNEVILLE , SHIGEYOSHI ITOHARA , EDVINS (0)
COCAINE-INDUCED EFFECTS ON MALE RAT SEXUAL BEHAVIOUR AND STRETCHING-YAWNING (0)
Potential biomarkers associated with malignancy in uterine mesenchymal tumors (0)
Author response: Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon (0)
Presynaptic m1 muscarinic receptors are necessary for mGluR LTD in the hippocampus (0)
Positive selection of 'GAMA''DELTA't cells (0)
B Lineage-Specific Interactions of an Innnunogiobulin Enhancer with Cellular Factors in vivo STOR (0)
Brain Science in the 21st Century : Toward Biology of Mind (0)
A Hippocampal Code for Experience Via Its Events as Abstract Units (0)
Do all murine intraepithelial leukocytes (IEL) have T cell receptor rearrangements (0)
Can We Understand the Mind by Studying the Brain (0)
Optogenetics 3.0 Accessed Terms of Use Detailed Terms (0)
Nmda receptor dependent visual cortical plasticity in the adult mouse in vivo (0)
2 – Lymphocyte Development and Function in T Cell Receptor and RAG-1 Mutant Mice (0)
Reiteration frequency of immunogl evidence for somatic generation of (RNA-DNA hybridization/X- and K-chain mRNAs) (0)
Defects in p21-activated kinase (PAK) in Alzheimer's disease: A causal role? (0)
Creativity-Cultivation and promotion. (0)
The somatic mutations in Interferon-γ signal molecules in human uterine leiomyosarcoma (0)
Confidence-guided updating of choice bias during perceptual decisions is a widespread behavioral phenomenon. (0)
Steve Ramirez Creating a False Memory in the Hippocampus (0)
Island Cells Control Temporal (0)
Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma (0)
Where is the Engram (0)
Genetic Origins of B and T Cell Antibodies (0)
Spinocerebellar mossy fiber terminal topography in the NR2C/PKCγ double mutant cerebellum (0)
Cortex Are Independent of Apical Dendrite Bundling Synaptic Connections between Layer 5B Pyramidal Neurons in Mouse Somatosensory (0)
PAK inhibitors for use in the treatment of neurodevelopmental disorders (0)
Nomenclature Revised nomenclature of mouse B-2 genes (0)
Â‘Neural Circuit Genetics of Hippocampal MemoryÂ’ (0)
Circadian Locomotor Rhythms in Mice with Targeted Disruption of the Gene for the Carbon Monoxide Synthesizing Enzyme, Heme Oxygenase-2 (0)
Proteasome LMP2/β1i subunit as biomarker for human uterine leiomyosarcoma (0)
DETERMINANTS OF MATERNAL AND INFANTICIDAL BEHAVIOR IN FEMALE MOUSE F1 HYBRIDS (0)
Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum. (0)
Reply to Lehr and Stöber: What’s in a name? On the distinction between temporal coding and internally driven activity (0)
A Conversation with Susumu Tonegawa. (0)
Spatial learning in mutant mice. Authors' reply (0)
1P203 Hippocampal CA3 NMDA receptors network is crucial for adaptive timing and retrieval of trace conditioning(Chemoreception, neuron and sensory system, neural network, and brain computing,Oral Presentations) (0)
A method for sensitizing a target cell by cytotoxic T lymph for analyzes. (0)
How does the hippocampus handle episodic memories? (0)
Increase in Positive Selection of CD8 + T Cells in TAPl-Mutant Mice by Human/~2-Microgl obulln Transgene By Hisse Martien van Santen,* Aaron Woolsey,* (0)
Proteasome Subunit LMP 2 / b 1 i As a Biomarker for Human Uterine Mesenchymal Tumors (0)
Functional Analysis of the TCRa ” + Cells That Accumulate in the Pneumonic Lung of Influenza Virus-Infected TCR-U-” Mice ’ (0)
NEUROPATHOLOGICAL STUDIES IN MICE HETEROZYGOUS FOR THE DISRUPTED PRESENILIN-1 GENE (0)
V and C parts of immunoglobulin kappa-chain genes are separate in myeloma. (0)
The Identification of Somatic Mutations in Interferon-g Signal Molecules in Human Uterine Leiomyosarcoma (0)
Title : Memory engram Cells Have Come of Age (0)
Tertiary and quaternary structure of the T cell receptor α β chain dimer (0)
USE OF THE GENE KNOCKOUT TECHNIQUE IN THE ANALYSES OF LEARNING AND THE WHISKER-BARREL SYSTEM (0)
Identification of Novel Biomarker For Human Uterine Leiomyosarcoma (0)
The Study of Somatic Mutations in Human Uterine Leiomyosarcoma (0)
Use of knockout mice for the studies on neural plasticity and memory (0)
Biological Analyses for Characterization of the Uterine Sarcoma Using Mouse Model (0)
Somatic Mutation Creates Diversity in Major Group of Mouse Immunoglobulin K Chains the Light (0)
Short communication Spinocerebellar mossy fiber terminal topography in the NR2C/PKC3/ double mutant cerebellum (0)
P599 - Reactivity and specificity of CD8+ T cells in MHC class I deficient mice (0)
CD8α+β− intestinal intraepithelial lymphocytes in T cell receptor transgenic mice are positively selected by high affinity ligands (0)
Molecular approaches of sarcomagenesis for establishment of clinical therapy (0)
Striosomes, but normal dynorphin-positive patches, are present in neonatal D1 receptor knockout mice (0)
The role of CA3 transmission in the acquisition and consolidation of spatial memory (0)
Sequence of a mouse germline gene for a variable region of an immunoglobulin light chain ( A light chain / hypervariable region / DNA sequencing / interspersed noncoding sequences ) (0)
Increase in Positive Selection o f C D 8 + T Cells in TAPl-Mutant Mice by Human / ~ 2-Microglobul ln Transgene By Hisse (0)
Restricted association ofVandJ-Cgenesegments formouse Alight chains (0)
Symposium S7: Regulation of Translation in Synaptic Plasticity & Memory (0)
Biological Significance of the Proteasome Subunit LMP2/1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma (0)
Author Correction: Hippocampal neurons represent events as transferable units of experience (0)
T-cell receptor v 6 and y transgenic mice suggest a role of a y gene silencer in the generation of c 48 T cells (0)

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