Thea Tlsty
#31,664
Most Influential Person Now
American pathologist
Thea Tlsty's AcademicInfluence.com Rankings
Thea Tlstybiology Degrees
Biology
#2346
World Rank
#3734
Historical Rank
Pathology
#112
World Rank
#224
Historical Rank
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Biology
Thea Tlsty's Degrees
- PhD Pathology University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Thea Tlsty Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thea D. Tlsty is an American pathologist and professor of pathology at the University of California, San Francisco . She is known for her research in cancer biology and her involvement in the discovery of cells that may be at the origin of metaplastic cancer, an invasive form of breast cancer.
Thea Tlsty's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Integrative analysis of 111 reference human epigenomes (2015) (4979)
- The clonal and mutational evolution spectrum of primary triple-negative breast cancers (2012) (1807)
- Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53 (1992) (1396)
- A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1376)
- Tumor stroma and regulation of cancer development. (2006) (1000)
- Benign breast disease and the risk of breast cancer. (2005) (859)
- Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype (1999) (674)
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy (2016) (496)
- Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes (2001) (484)
- Know thy neighbor: stromal cells can contribute oncogenic signals. (2001) (400)
- Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. (1994) (395)
- Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. (2010) (340)
- DNA replication licensing and human cell proliferation. (2001) (326)
- Stromal cells can contribute oncogenic signals. (2001) (317)
- An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control. (1998) (267)
- Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. (2003) (247)
- Stratification of breast cancer risk in women with atypia: a Mayo cohort study. (2007) (228)
- Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. (2007) (226)
- Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. (1989) (223)
- Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers (2008) (213)
- Moving AHEAD with an international human epigenome project (2008) (202)
- DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape (2013) (191)
- Tumor microenvironment and progression (2011) (181)
- Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea (1983) (179)
- Normal diploid human and rodent cells lack a detectable frequency of gene amplification. (1990) (170)
- Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. (1995) (164)
- Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. (2013) (163)
- Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm (2013) (158)
- A physical sciences network characterization of non-tumorigenic and metastatic cells (2013) (157)
- An analogy between the evolution of drug resistance in bacterial communities and malignant tissues (2011) (152)
- CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. (2012) (152)
- Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. (2004) (152)
- Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. (2000) (140)
- Gene amplification in the lac region of E. coli (1984) (139)
- Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells* (2006) (134)
- p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells (2006) (128)
- Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. (2001) (128)
- UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells (1984) (126)
- Cell-adhesion-dependent influences on genomic instability and carcinogenesis. (1998) (111)
- Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. (2002) (109)
- The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. (1975) (106)
- Distribution of ultraviolet-induced DNA repair synthesis in nuclease sensitive and resistant regions of human chromatin. (1978) (104)
- Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. (2003) (95)
- Genetic and Epigenetic Changes in Mammary Epithelial Cells May Mimic Early Events in Carcinogenesis (2004) (91)
- Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation (1996) (85)
- Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development (2010) (85)
- Intermediate DNA methylation is a conserved signature of genome regulation (2015) (81)
- Rare somatic cells from human breast tissue exhibit extensive lineage plasticity (2013) (80)
- Suppression of gene amplification in human cell hybrids. (1992) (78)
- Genomic instability and cancer (1995) (77)
- Inactivation of p53 Function in Cultured Human Mammary Epithelial Cells Turns the Telomere-Length Dependent Senescence Barrier from Agonescence into Crisis (2007) (75)
- Cell motility and drug gradients in the emergence of resistance to chemotherapy (2013) (74)
- Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. (1989) (74)
- Simulating Properties of In Vitro Epithelial Cell Morphogenesis (2006) (73)
- A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death. (1998) (73)
- Insertion, excision, and inversion of Tn5. (1981) (73)
- The role of stroma in prostatic carcinogenesis (1998) (65)
- p16INK4a modulates p53 in primary human mammary epithelial cells. (2006) (62)
- p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. (2005) (59)
- Epigenetic and transcriptional determinants of the human breast (2015) (57)
- Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. (2017) (54)
- Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis. (2005) (51)
- Cellular adhesion regulates p53 protein levels in primary human keratinocytes. (1997) (51)
- Genetic and epigenetic influences in prostatic carcinogenesis (review). (1998) (51)
- Methylation of p 16 INK 4 a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia 1 (2003) (50)
- Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF (2007) (50)
- Genomic instability and its role in neoplasia. (1997) (48)
- Loss of Chromosomal Integrity in Human Mammary Epithelial Cells Subsequent to Escape from Senescence (2001) (46)
- Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts. (1993) (44)
- Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light (1999) (41)
- Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes (2012) (39)
- The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene. (1978) (38)
- Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy (2009) (37)
- Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment (2014) (35)
- Premalignant Breast Neoplasia: A Paradigm of Interlesional and Intralesional Molecular Heterogeneity and Its Biological and Clinical Ramifications (2010) (34)
- Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. (2013) (33)
- Rapid emergence of methotrexate resistance in cultured mouse cells. (1984) (33)
- DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions (2009) (32)
- p16INK4a Expression and Breast Cancer Risk in Women with Atypical Hyperplasia (2011) (29)
- Reflections on miR-ing effects in metastasis. (2009) (28)
- Regulatory Network Decoded from Epigenomes of Surface Ectoderm-Derived Cell Types (2014) (27)
- Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli. (1983) (26)
- Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations (2014) (24)
- Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital. (1998) (22)
- Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. (2014) (22)
- Conceptualizing a tool to optimize therapy based on dynamic heterogeneity (2012) (20)
- Graphical methods for quantifying macromolecules through bright field imaging (2008) (19)
- Unprecedented Opportunities and Promise for Cancer Prevention Research (2010) (19)
- Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations (2014) (18)
- Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy (2016) (18)
- Loss of chromosomal integrity in neoplasia. (1993) (16)
- Cancer: Whispering sweet somethings (2008) (16)
- Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer. (2002) (16)
- Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. (1996) (15)
- Analysis of cell cycle checkpoint status in mammalian cells. (1995) (14)
- Luminal cells GATA have it (2007) (14)
- Stromal directives can control cancer (2019) (14)
- A molecular blueprint for targeting cancer? (1999) (13)
- Genomic integrity and the genetics of cancer. (1994) (11)
- Generalized principles of stochasticity can be used to control dynamic heterogeneity (2012) (10)
- p 16 INK 4 a Modulates p 53 in Primary Human Mammary Epithelial Cells (2006) (10)
- 1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells. (1989) (10)
- Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens. (1993) (9)
- Pregnancy and obesity modify the epithelial composition and hormone signaling state of the human breast (2020) (8)
- SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73. (2016) (8)
- Regulation of genomic instability in preneoplastic cells. (1996) (7)
- Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization (2015) (7)
- Mapping the complex paracrine response to hormones in the human breast at single-cell resolution (2018) (7)
- Identification of additional complementation groups that regulate genomic instability (1997) (7)
- Morphologically Normal-AppearingMammary Epithelial Cells Obtained from High-RiskWomen Exhibit Methylation Silencing of INK 4 a / ARF (2007) (6)
- Changes in epithelial proportions and transcriptional state underlie major premenopausal breast cancer risks (2018) (6)
- Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line. (1990) (5)
- Clonal variation of tumorigenic potential in v‐Ha‐ras‐transformed human bronchial epithelial cells: Relationship to ras oncogene expression and CAD gene amplification (1994) (5)
- Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution. (2022) (5)
- Defective G 2 Checkpoint Function in Cells from Individuals with Familial Cancer Syndromes 1 (2006) (4)
- Cell cycle control and genomic instability (1995) (4)
- Searching for targets: the power of somatic cell genetics. (2001) (3)
- p16 Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells (2006) (3)
- Hello out there...is anybody listening? (2012) (2)
- A twist of cell fate. (2011) (2)
- Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology (2012) (2)
- Integrative analysis of 111 reference human epigenomes Open (2015) (2)
- Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas (2022) (2)
- Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma (2022) (1)
- [22]Gene amplification as marker for studying genomic instability (1996) (1)
- Abrogation of cell cycle checkpoint control in preneoplastic cells (1995) (1)
- A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1)
- Remaining true to one’s identity (2021) (1)
- Scoring histological sections through immunohistochemistry (2008) (1)
- Cancer heterogeneity : Impact on carcinogenesis, cancer stem cell, microenvironment, diagnosis and treatment : extended abstracts for the 43rd International Symposium of the Princess Takamatsu Cancer Research Fund : November 14-16, 2012 Tokyo, Japan (2013) (0)
- human mammary cells spontaneously escape senescence and acquire genomic changes. (2022) (0)
- Stromal directives can control cancer Could reprogramming the pretumor microenvironment transform cancer care? (2019) (0)
- The acquisition of methotrexate resistance by gene amplification (1984) (0)
- Title Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength Permalink (2017) (0)
- Tissue states provide novel insights into attributes that drive metastasis. (2011) (0)
- p16 hypermethylation is observed as an early event in mammary carcinogenesis. (2006) (0)
- CARCINOMA-ASSOCIATED FIBROBLASTS PROMOTE INVASION OF PROSTATIC EPITHELIAL CELLS (1999) (0)
- Gene Amplification in Nontumorigenic and Tumorigenic Mammalian Cells (2020) (0)
- Modification of Epigenetic Changes in Cancer by the Stromal Environment (2004) (0)
- Was Anybody Listening? (1963) (0)
- P5-08-02: Mammographic Breast Texture Predicts Benign Biopsy Results and Composition. (2011) (0)
- Tu1165: THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS (2022) (0)
- Abstract LB-273: The tumor suppressor p16INK4a regulates extensive plasticity in rare somatic cells found in adult human tissue. (2013) (0)
- p16 Expression and Breast Cancer Risk in Women with Atypical Hyperplasia. (2009) (0)
- Short Abstracts – Session II (2007) (0)
- Pluripotent Cells: New Tools for Disease Research and Therapies (2016) (0)
- Stromal Influences in Prostatic Carcinogenesis (2001) (0)
- Abstract LB-334: Signals from the microenvironment induce a malignant program accompanied by de novo epigenetic remodeling (2008) (0)
- Does the Expression of Ki-67, p16 and COX-2 at Initial Diagnosis of Breast Atypia or Usual Ductal Hyperplasia Predict a Second Clinically Significant Event? (2015) (0)
- Familial Cancer Syndromes Checkpoint Function in Cells from Individuals with 2 Defective G Updated (2006) (0)
- Predictive biomarkers of invasive carcinoma on excision in patients with a diagnosis of ductal carcinoma in situ of the breast by needle biopsy. (2014) (0)
- Mechanisms of genetic and epigenetic (tumor/stem) cell plasticity. (2006) (0)
- Introducing cancer convergence (2017) (0)
- Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes (2012) (0)
- Abstract P5-16-04: Predictive biomarkers for invasion on final pathology in patients with preoperative diagnosis of ductal carcinoma in situ of the breast by needle biopsy (2013) (0)
- Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. (2015) (0)
- Multiple Mechanisms of 7 V-( Phosphonoacetyl )-L-aspartate Drug Resistance in SV 40-infected Precrisis Human Fibroblasts 1 (2006) (0)
- Advances in Brief Separate Pathways for p 53 Induction by Ionizing Radiation and AKPhosphonoacetyO-L-aspartate 1 (2006) (0)
- Epithelial-Stromal Interactions in Barrett’s Esophagus Modeled in Human Organ Chips (2023) (0)
- Multiple Mechanisms of 7V-(Phosphonoacetyl)-L-aspartate Drug Resistance in SV40-infected Precrisis Human Fibroblasts1 (2006) (0)
- Telomere Structure and Function Provides Insights into the Generation of Genomic Instability and Carcinogenesis (2005) (0)
- Extended abstract: Abrogation of cell cycle checkpoint control in preneoplastic cells (1995) (0)
- IN THE SPOTLIGHT Hello Out There...Is Anybody Listening (2012) (0)
- Abstract OT3-09-02: A large-scale multicenter phase II study evaluating the protective effect of a tissue selective estrogen complex (TSEC) in women with newly diagnosed ductal carcinoma in situ (DCIS) (2020) (0)
- Enhancement ofMethotrexate Resistance andDihydrofolate Reductase GeneAmplification byTreatment ofMouse3T6 Cells withHydroxyurea (1983) (0)
- 970: DISCRETE FIBROBLAST SUBSETS NURTURE GASTRIC CARCINOGENESIS (2022) (0)
- Abstract IA-14: Molecular alterations that predict premalignancy in breast cancer (2009) (0)
- The Role of the Microenvironment in the Origins of Cancer (2014) (0)
- Abstract P5-18-04: HER2 overexpression in ductal carcinoma in situ: A biomarker for risk stratification and therapeutic implication (2019) (0)
- Towards Self-Immolating Fluorescent Probes for Cyclooxygenases (2015) (0)
- Cyclooxygenase-2 Expression Is Related to Nuclear Grade in Ductal Carcinoma in Situ and Is Increased in Its Normal Adjacent Epithelium 1 (2003) (0)
- Title Novel insights from 3 D models : The pivotal role of physical symmetry in epithelial organization Permalink (2015) (0)
- Genetic regulation of genomic fluidity in normal and neoplastic cells (1993) (0)
- Introducing cancer convergence (2017) (0)
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